SEQUENCE LISTING < 110 > Mitsubishi Rayon Co . , Ltd . < 120 > Halohydrin epoxidase < 130 > PCT 08 - 0006 < 150 > JP 2007 - 057854 < 151 > 2007 - 03 - 07 < 160 > 91 < 170 > PatentIn version 3 . 4 < 210 > 1 < 211 > 235 < 212 > PRT < 213 > Corynebacterium < 400 > 1 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe 130 135 140 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Asp Ala 195 200 205 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 2 < 211 > 227 < 212 > PRT < 213 > Corynebacterium < 400 > 2 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 Leu Ala Tyr Ser Thr Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 Leu Ala Thr Ala Arg Glu Asp Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 Trp Ala Thr 225 < 210 > 3 < 211 > 235 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 3 Met Lys Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe 130 135 140 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Asp Ala 195 200 205 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 4 < 211 > 235 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 4 Met Asn Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe 130 135 140 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Asp Ala 195 200 205 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 5 < 211 > 235 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 5 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Ala Ala Arg Phe 130 135 140 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Asp Ala 195 200 205 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 6 < 211 > 235 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 6 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Cys Ala Arg Phe 130 135 140 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Asp Ala 195 200 205 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 7 < 211 > 235 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 7 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Ser Ala Arg Phe 130 135 140 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Asp Ala 195 200 205 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 8 < 211 > 235 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 8 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Ala 130 135 140 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Asp Ala 195 200 205 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 9 < 211 > 235 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 9 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Ser 130 135 140 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Asp Ala 195 200 205 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 10 < 211 > 235 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 10 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe 130 135 140 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Gln Ala 195 200 205 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 11 < 211 > 235 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 11 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe 130 135 140 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Glu Ala 195 200 205 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 12 < 211 > 235 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 12 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe 130 135 140 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu His Ala 195 200 205 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 13 < 211 > 235 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 13 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe 130 135 140 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Ser Ala 195 200 205 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 14 < 211 > 235 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 14 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe 130 135 140 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Thr Ala 195 200 205 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 15 < 211 > 235 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 15 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe 130 135 140 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Tyr Ala 195 200 205 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 16 < 211 > 227 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 16 Met Lys Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 Leu Ala Tyr Ser Thr Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 Leu Ala Thr Ala Arg Glu Asp Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 Trp Ala Thr 225 < 210 > 17 < 211 > 227 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 17 Met Asn Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 Leu Ala Tyr Ser Thr Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 Leu Ala Thr Ala Arg Glu Asp Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 Trp Ala Thr 225 < 210 > 18 < 211 > 227 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 18 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 Leu Ala Tyr Ser Ala Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 Leu Ala Thr Ala Arg Glu Asp Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 Trp Ala Thr 225 < 210 > 19 < 211 > 227 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 19 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 Leu Ala Tyr Ser Cys Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 Leu Ala Thr Ala Arg Glu Asp Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 Trp Ala Thr 225 < 210 > 20 < 211 > 227 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 20 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 Leu Ala Tyr Ser Ser Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 Leu Ala Thr Ala Arg Glu Asp Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 Trp Ala Thr 225 < 210 > 21 < 211 > 227 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 21 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 Leu Ala Tyr Ser Thr Ala Arg Ala Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 Leu Ala Thr Ala Arg Glu Asp Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 Trp Ala Thr 225 < 210 > 22 < 211 > 227 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 22 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 Leu Ala Tyr Ser Thr Ala Arg Ser Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 Leu Ala Thr Ala Arg Glu Asp Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 Trp Ala Thr 225 < 210 > 23 < 211 > 227 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 23 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 Leu Ala Tyr Ser Thr Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 Leu Ala Thr Ala Arg Glu Gln Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 Trp Ala Thr 225 < 210 > 24 < 211 > 227 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 24 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 Leu Ala Tyr Ser Thr Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 Leu Ala Thr Ala Arg Glu Glu Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 Trp Ala Thr 225 < 210 > 25 < 211 > 227 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 25 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 Leu Ala Tyr Ser Thr Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 Leu Ala Thr Ala Arg Glu His Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 Trp Ala Thr 225 < 210 > 26 < 211 > 227 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 26 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 Leu Ala Tyr Ser Thr Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 Leu Ala Thr Ala Arg Glu Ser Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 Trp Ala Thr 225 < 210 > 27 < 211 > 227 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 27 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 Leu Ala Tyr Ser Thr Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 Leu Ala Thr Ala Arg Glu Thr Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 Trp Ala Thr 225 < 210 > 28 < 211 > 227 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 28 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 Leu Ala Tyr Ser Thr Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 Leu Ala Thr Ala Arg Glu Tyr Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 Trp Ala Thr 225 < 210 > 29 < 211 > 708 < 212 > DNA < 213 > Corynebacterium < 400 > 29 atggctaacg gaaggaaaag ggaaatggct aacggaagac tggcaggcaa gcgggtccta 60 ctcacgaacg ccgatgccta catgggtgag gccacggtcc aggtgttcga ggaggagggc 120 gcagaggtca tcgctgacca caccgacttg acgaaggtcg gcgcggcgga ggaggtcgtc 180 gagagggctg ggcacatcga tgtcctggtg gccaacttcg cggtcgacgc ccacttcggg 240 gtgaccgtgc tggagaccga cgaggagctg tggcagacgg cctacgagac catcgtgcac 300 ccgctgcatc ggatctgccg tgcggtgctc ccgcagttct acgagcggaa caagggcaag 360 atcgttgtct acggaagtgc cgcagcgatg cggtaccagg aaggtgcgct ggcctacagc 420 acggcgcgtt tcgctcagcg cgggtacgtc accgccctcg gtcccgaggc agcgaggcac 480 aacgtcaacg tgaacttcat cgcccagcac tggacccaaa acaaggagta cttctggccc 540 gagcgcatcg ccaccgacga gttcaaggag gatatggcgc gccgagttcc cctgggtcgg 600 ctcgcgactg cccgagagga cgcgctgctc gcgttgttcc tggcctcgga cgagagtgac 660 ttcatcgtcg gcaagtcgat cgagttcgac ggcggctggg ccacctga 708 < 210 > 30 < 211 > 684 < 212 > DNA < 213 > Corynebacterium < 400 > 30 atggctaacg gaagactggc aggcaagcgg gtcctactca cgaacgccga tgcctacatg 60 ggtgaggcca cggtccaggt gttcgaggag gagggcgcag aggtcatcgc tgaccacacc 120 gacttgacga aggtcggcgc ggcggaggag gtcgtcgaga gggctgggca catcgatgtc 180 ctggtggcca acttcgcggt cgacgcccac ttcggggtga ccgtgctgga gaccgacgag 240 gagctgtggc agacggccta cgagaccatc gtgcacccgc tgcatcggat ctgccgtgcg 300 gtgctcccgc agttctacga gcggaacaag ggcaagatcg ttgtctacgg aagtgccgca 360 gcgatgcggt accaggaagg tgcgctggcc tacagcacgg cgcgtttcgc tcagcgcggg 420 tacgtcaccg ccctcggtcc cgaggcagcg aggcacaacg tcaacgtgaa cttcatcgcc 480 cagcactgga cccaaaacaa ggagtacttc tggcccgagc gcatcgccac cgacgagttc 540 aaggaggata tggcgcgccg agttcccctg ggtcggctcg cgactgcccg agaggacgcg 600 ctgctcgcgt tgttcctggc ctcggacgag agtgacttca tcgtcggcaa gtcgatcgag 660 ttcgacggcg gctgggccac ctga 684 < 210 > 31 < 211 > 708 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 708 ) < 400 > 31 atg aaa aac gga agg aaa agg gaa atg gct aac gga aga ctg gca ggc 48 Met Lys Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 aag cgg gtc cta ctc acg aac gcc gat gcc tac atg ggt gag gcc acg 96 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 gtc cag gtg ttc gag gag gag ggc gca gag gtc atc gct gac cac acc 144 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 gac ttg acg aag gtc ggc gcg gcg gag gag gtc gtc gag agg gct ggg 192 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 cac atc gat gtc ctg gtg gcc aac ttc gcg gtc gac gcc cac ttc ggg 240 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 gtg acc gtg ctg gag acc gac gag gag ctg tgg cag acg gcc tac gag 288 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 acc atc gtg cac ccg ctg cat cgg atc tgc cgt gcg gtg ctc ccg cag 336 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 ttc tac gag cgg aac aag ggc aag atc gtt gtc tac gga agt gcc gca 384 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 gcg atg cgg tac cag gaa ggt gcg ctg gcc tac agc acg gcg cgt ttc 432 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe 130 135 140 gct cag cgc ggg tac gtc acc gcc ctc ggt ccc gag gca gcg agg cac 480 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 aac gtc aac gtg aac ttc atc gcc cag cac tgg acc caa aac aag gag 528 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 tac ttc tgg ccc gag cgc atc gcc acc gac gag ttc aag gag gat atg 576 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 gcg cgc cga gtt ccc ctg ggt cgg ctc gcg act gcc cga gag gac gcg 624 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Asp Ala 195 200 205 ctg ctc gcg ttg ttc ctg gcc tcg gac gag agt gac ttc atc gtc ggc 672 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 aag tcg atc gag ttc gac ggc ggc tgg gcc acc tga 708 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 32 < 211 > 708 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 708 ) < 400 > 32 atg aac aac gga agg aaa agg gaa atg gct aac gga aga ctg gca ggc 48 Met Asn Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 aag cgg gtc cta ctc acg aac gcc gat gcc tac atg ggt gag gcc acg 96 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 gtc cag gtg ttc gag gag gag ggc gca gag gtc atc gct gac cac acc 144 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 gac ttg acg aag gtc ggc gcg gcg gag gag gtc gtc gag agg gct ggg 192 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 cac atc gat gtc ctg gtg gcc aac ttc gcg gtc gac gcc cac ttc ggg 240 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 gtg acc gtg ctg gag acc gac gag gag ctg tgg cag acg gcc tac gag 288 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 acc atc gtg cac ccg ctg cat cgg atc tgc cgt gcg gtg ctc ccg cag 336 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 ttc tac gag cgg aac aag ggc aag atc gtt gtc tac gga agt gcc gca 384 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 gcg atg cgg tac cag gaa ggt gcg ctg gcc tac agc acg gcg cgt ttc 432 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe 130 135 140 gct cag cgc ggg tac gtc acc gcc ctc ggt ccc gag gca gcg agg cac 480 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 aac gtc aac gtg aac ttc atc gcc cag cac tgg acc caa aac aag gag 528 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 tac ttc tgg ccc gag cgc atc gcc acc gac gag ttc aag gag gat atg 576 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 gcg cgc cga gtt ccc ctg ggt cgg ctc gcg act gcc cga gag gac gcg 624 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Asp Ala 195 200 205 ctg ctc gcg ttg ttc ctg gcc tcg gac gag agt gac ttc atc gtc ggc 672 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 aag tcg atc gag ttc gac ggc ggc tgg gcc acc tga 708 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 33 < 211 > 708 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 708 ) < 400 > 33 atg gct aac gga agg aaa agg gaa atg gct aac gga aga ctg gca ggc 48 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 aag cgg gtc cta ctc acg aac gcc gat gcc tac atg ggt gag gcc acg 96 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 gtc cag gtg ttc gag gag gag ggc gca gag gtc atc gct gac cac acc 144 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 gac ttg acg aag gtc ggc gcg gcg gag gag gtc gtc gag agg gct ggg 192 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 cac atc gat gtc ctg gtg gcc aac ttc gcg gtc gac gcc cac ttc ggg 240 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 gtg acc gtg ctg gag acc gac gag gag ctg tgg cag acg gcc tac gag 288 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 acc atc gtg cac ccg ctg cat cgg atc tgc cgt gcg gtg ctc ccg cag 336 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 ttc tac gag cgg aac aag ggc aag atc gtt gtc tac gga agt gcc gca 384 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 gcg atg cgg tac cag gaa ggt gcg ctg gcc tac agc gcg gcg cgt ttc 432 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Ala Ala Arg Phe 130 135 140 gct cag cgc ggg tac gtc acc gcc ctc ggt ccc gag gca gcg agg cac 480 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 aac gtc aac gtg aac ttc atc gcc cag cac tgg acc caa aac aag gag 528 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 tac ttc tgg ccc gag cgc atc gcc acc gac gag ttc aag gag gat atg 576 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 gcg cgc cga gtt ccc ctg ggt cgg ctc gcg act gcc cga gag gac gcg 624 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Asp Ala 195 200 205 ctg ctc gcg ttg ttc ctg gcc tcg gac gag agt gac ttc atc gtc ggc 672 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 aag tcg atc gag ttc gac ggc ggc tgg gcc acc tga 708 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 34 < 211 > 708 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 708 ) < 400 > 34 atg gct aac gga agg aaa agg gaa atg gct aac gga aga ctg gca ggc 48 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 aag cgg gtc cta ctc acg aac gcc gat gcc tac atg ggt gag gcc acg 96 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 gtc cag gtg ttc gag gag gag ggc gca gag gtc atc gct gac cac acc 144 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 gac ttg acg aag gtc ggc gcg gcg gag gag gtc gtc gag agg gct ggg 192 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 cac atc gat gtc ctg gtg gcc aac ttc gcg gtc gac gcc cac ttc ggg 240 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 gtg acc gtg ctg gag acc gac gag gag ctg tgg cag acg gcc tac gag 288 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 acc atc gtg cac ccg ctg cat cgg atc tgc cgt gcg gtg ctc ccg cag 336 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 ttc tac gag cgg aac aag ggc aag atc gtt gtc tac gga agt gcc gca 384 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 gcg atg cgg tac cag gaa ggt gcg ctg gcc tac agc tgt gcg cgt ttc 432 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Cys Ala Arg Phe 130 135 140 gct cag cgc ggg tac gtc acc gcc ctc ggt ccc gag gca gcg agg cac 480 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 aac gtc aac gtg aac ttc atc gcc cag cac tgg acc caa aac aag gag 528 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 tac ttc tgg ccc gag cgc atc gcc acc gac gag ttc aag gag gat atg 576 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 gcg cgc cga gtt ccc ctg ggt cgg ctc gcg act gcc cga gag gac gcg 624 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Asp Ala 195 200 205 ctg ctc gcg ttg ttc ctg gcc tcg gac gag agt gac ttc atc gtc ggc 672 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 aag tcg atc gag ttc gac ggc ggc tgg gcc acc tga 708 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 35 < 211 > 708 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 708 ) < 400 > 35 atg gct aac gga agg aaa agg gaa atg gct aac gga aga ctg gca ggc 48 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 aag cgg gtc cta ctc acg aac gcc gat gcc tac atg ggt gag gcc acg 96 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 gtc cag gtg ttc gag gag gag ggc gca gag gtc atc gct gac cac acc 144 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 gac ttg acg aag gtc ggc gcg gcg gag gag gtc gtc gag agg gct ggg 192 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 cac atc gat gtc ctg gtg gcc aac ttc gcg gtc gac gcc cac ttc ggg 240 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 gtg acc gtg ctg gag acc gac gag gag ctg tgg cag acg gcc tac gag 288 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 acc atc gtg cac ccg ctg cat cgg atc tgc cgt gcg gtg ctc ccg cag 336 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 ttc tac gag cgg aac aag ggc aag atc gtt gtc tac gga agt gcc gca 384 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 gcg atg cgg tac cag gaa ggt gcg ctg gcc tac agc tct gcg cgt ttc 432 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Ser Ala Arg Phe 130 135 140 gct cag cgc ggg tac gtc acc gcc ctc ggt ccc gag gca gcg agg cac 480 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 aac gtc aac gtg aac ttc atc gcc cag cac tgg acc caa aac aag gag 528 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 tac ttc tgg ccc gag cgc atc gcc acc gac gag ttc aag gag gat atg 576 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 gcg cgc cga gtt ccc ctg ggt cgg ctc gcg act gcc cga gag gac gcg 624 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Asp Ala 195 200 205 ctg ctc gcg ttg ttc ctg gcc tcg gac gag agt gac ttc atc gtc ggc 672 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 aag tcg atc gag ttc gac ggc ggc tgg gcc acc tga 708 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 36 < 211 > 708 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 708 ) < 400 > 36 atg gct aac gga agg aaa agg gaa atg gct aac gga aga ctg gca ggc 48 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 aag cgg gtc cta ctc acg aac gcc gat gcc tac atg ggt gag gcc acg 96 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 gtc cag gtg ttc gag gag gag ggc gca gag gtc atc gct gac cac acc 144 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 gac ttg acg aag gtc ggc gcg gcg gag gag gtc gtc gag agg gct ggg 192 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 cac atc gat gtc ctg gtg gcc aac ttc gcg gtc gac gcc cac ttc ggg 240 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 gtg acc gtg ctg gag acc gac gag gag ctg tgg cag acg gcc tac gag 288 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 acc atc gtg cac ccg ctg cat cgg atc tgc cgt gcg gtg ctc ccg cag 336 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 ttc tac gag cgg aac aag ggc aag atc gtt gtc tac gga agt gcc gca 384 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 gcg atg cgg tac cag gaa ggt gcg ctg gcc tac agc acg gcg cgt gcg 432 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Ala 130 135 140 gct cag cgc ggg tac gtc acc gcc ctc ggt ccc gag gca gcg agg cac 480 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 aac gtc aac gtg aac ttc atc gcc cag cac tgg acc caa aac aag gag 528 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 tac ttc tgg ccc gag cgc atc gcc acc gac gag ttc aag gag gat atg 576 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 gcg cgc cga gtt ccc ctg ggt cgg ctc gcg act gcc cga gag gac gcg 624 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Asp Ala 195 200 205 ctg ctc gcg ttg ttc ctg gcc tcg gac gag agt gac ttc atc gtc ggc 672 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 aag tcg atc gag ttc gac ggc ggc tgg gcc acc tga 708 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 37 < 211 > 708 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 708 ) < 400 > 37 atg gct aac gga agg aaa agg gaa atg gct aac gga aga ctg gca ggc 48 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 aag cgg gtc cta ctc acg aac gcc gat gcc tac atg ggt gag gcc acg 96 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 gtc cag gtg ttc gag gag gag ggc gca gag gtc atc gct gac cac acc 144 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 gac ttg acg aag gtc ggc gcg gcg gag gag gtc gtc gag agg gct ggg 192 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 cac atc gat gtc ctg gtg gcc aac ttc gcg gtc gac gcc cac ttc ggg 240 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 gtg acc gtg ctg gag acc gac gag gag ctg tgg cag acg gcc tac gag 288 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 acc atc gtg cac ccg ctg cat cgg atc tgc cgt gcg gtg ctc ccg cag 336 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 ttc tac gag cgg aac aag ggc aag atc gtt gtc tac gga agt gcc gca 384 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 gcg atg cgg tac cag gaa ggt gcg ctg gcc tac agc acg gcg cgt tcc 432 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Ser 130 135 140 gct cag cgc ggg tac gtc acc gcc ctc ggt ccc gag gca gcg agg cac 480 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 aac gtc aac gtg aac ttc atc gcc cag cac tgg acc caa aac aag gag 528 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 tac ttc tgg ccc gag cgc atc gcc acc gac gag ttc aag gag gat atg 576 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 gcg cgc cga gtt ccc ctg ggt cgg ctc gcg act gcc cga gag gac gcg 624 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Asp Ala 195 200 205 ctg ctc gcg ttg ttc ctg gcc tcg gac gag agt gac ttc atc gtc ggc 672 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 aag tcg atc gag ttc gac ggc ggc tgg gcc acc tga 708 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 38 < 211 > 708 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 708 ) < 400 > 38 atg gct aac gga agg aaa agg gaa atg gct aac gga aga ctg gca ggc 48 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 aag cgg gtc cta ctc acg aac gcc gat gcc tac atg ggt gag gcc acg 96 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 gtc cag gtg ttc gag gag gag ggc gca gag gtc atc gct gac cac acc 144 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 gac ttg acg aag gtc ggc gcg gcg gag gag gtc gtc gag agg gct ggg 192 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 cac atc gat gtc ctg gtg gcc aac ttc gcg gtc gac gcc cac ttc ggg 240 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 gtg acc gtg ctg gag acc gac gag gag ctg tgg cag acg gcc tac gag 288 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 acc atc gtg cac ccg ctg cat cgg atc tgc cgt gcg gtg ctc ccg cag 336 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 ttc tac gag cgg aac aag ggc aag atc gtt gtc tac gga agt gcc gca 384 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 gcg atg cgg tac cag gaa ggt gcg ctg gcc tac agc acg gcg cgt ttc 432 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe 130 135 140 gct cag cgc ggg tac gtc acc gcc ctc ggt ccc gag gca gcg agg cac 480 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 aac gtc aac gtg aac ttc atc gcc cag cac tgg acc caa aac aag gag 528 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 tac ttc tgg ccc gag cgc atc gcc acc gac gag ttc aag gag gat atg 576 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 gcg cgc cga gtt ccc ctg ggt cgg ctc gcg act gcc cga gag caa gcg 624 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Gln Ala 195 200 205 ctg ctc gcg ttg ttc ctg gcc tcg gac gag agt gac ttc atc gtc ggc 672 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 aag tcg atc gag ttc gac ggc ggc tgg gcc acc tga 708 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 39 < 211 > 708 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 708 ) < 400 > 39 atg gct aac gga agg aaa agg gaa atg gct aac gga aga ctg gca ggc 48 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 aag cgg gtc cta ctc acg aac gcc gat gcc tac atg ggt gag gcc acg 96 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 gtc cag gtg ttc gag gag gag ggc gca gag gtc atc gct gac cac acc 144 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 gac ttg acg aag gtc ggc gcg gcg gag gag gtc gtc gag agg gct ggg 192 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 cac atc gat gtc ctg gtg gcc aac ttc gcg gtc gac gcc cac ttc ggg 240 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 gtg acc gtg ctg gag acc gac gag gag ctg tgg cag acg gcc tac gag 288 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 acc atc gtg cac ccg ctg cat cgg atc tgc cgt gcg gtg ctc ccg cag 336 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 ttc tac gag cgg aac aag ggc aag atc gtt gtc tac gga agt gcc gca 384 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 gcg atg cgg tac cag gaa ggt gcg ctg gcc tac agc acg gcg cgt ttc 432 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe 130 135 140 gct cag cgc ggg tac gtc acc gcc ctc ggt ccc gag gca gcg agg cac 480 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 aac gtc aac gtg aac ttc atc gcc cag cac tgg acc caa aac aag gag 528 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 tac ttc tgg ccc gag cgc atc gcc acc gac gag ttc aag gag gat atg 576 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 gcg cgc cga gtt ccc ctg ggt cgg ctc gcg act gcc cga gag gag gcg 624 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Glu Ala 195 200 205 ctg ctc gcg ttg ttc ctg gcc tcg gac gag agt gac ttc atc gtc ggc 672 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 aag tcg atc gag ttc gac ggc ggc tgg gcc acc tga 708 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 40 < 211 > 708 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 708 ) < 400 > 40 atg gct aac gga agg aaa agg gaa atg gct aac gga aga ctg gca ggc 48 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 aag cgg gtc cta ctc acg aac gcc gat gcc tac atg ggt gag gcc acg 96 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 gtc cag gtg ttc gag gag gag ggc gca gag gtc atc gct gac cac acc 144 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 gac ttg acg aag gtc ggc gcg gcg gag gag gtc gtc gag agg gct ggg 192 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 cac atc gat gtc ctg gtg gcc aac ttc gcg gtc gac gcc cac ttc ggg 240 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 gtg acc gtg ctg gag acc gac gag gag ctg tgg cag acg gcc tac gag 288 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 acc atc gtg cac ccg ctg cat cgg atc tgc cgt gcg gtg ctc ccg cag 336 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 ttc tac gag cgg aac aag ggc aag atc gtt gtc tac gga agt gcc gca 384 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 gcg atg cgg tac cag gaa ggt gcg ctg gcc tac agc acg gcg cgt ttc 432 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe 130 135 140 gct cag cgc ggg tac gtc acc gcc ctc ggt ccc gag gca gcg agg cac 480 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 aac gtc aac gtg aac ttc atc gcc cag cac tgg acc caa aac aag gag 528 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 tac ttc tgg ccc gag cgc atc gcc acc gac gag ttc aag gag gat atg 576 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 gcg cgc cga gtt ccc ctg ggt cgg ctc gcg act gcc cga gag cac gcg 624 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu His Ala 195 200 205 ctg ctc gcg ttg ttc ctg gcc tcg gac gag agt gac ttc atc gtc ggc 672 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 aag tcg atc gag ttc gac ggc ggc tgg gcc acc tga 708 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 41 < 211 > 708 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 708 ) < 400 > 41 atg gct aac gga agg aaa agg gaa atg gct aac gga aga ctg gca ggc 48 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 aag cgg gtc cta ctc acg aac gcc gat gcc tac atg ggt gag gcc acg 96 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 gtc cag gtg ttc gag gag gag ggc gca gag gtc atc gct gac cac acc 144 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 gac ttg acg aag gtc ggc gcg gcg gag gag gtc gtc gag agg gct ggg 192 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 cac atc gat gtc ctg gtg gcc aac ttc gcg gtc gac gcc cac ttc ggg 240 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 gtg acc gtg ctg gag acc gac gag gag ctg tgg cag acg gcc tac gag 288 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 acc atc gtg cac ccg ctg cat cgg atc tgc cgt gcg gtg ctc ccg cag 336 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 ttc tac gag cgg aac aag ggc aag atc gtt gtc tac gga agt gcc gca 384 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 gcg atg cgg tac cag gaa ggt gcg ctg gcc tac agc acg gcg cgt ttc 432 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe 130 135 140 gct cag cgc ggg tac gtc acc gcc ctc ggt ccc gag gca gcg agg cac 480 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 aac gtc aac gtg aac ttc atc gcc cag cac tgg acc caa aac aag gag 528 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 tac ttc tgg ccc gag cgc atc gcc acc gac gag ttc aag gag gat atg 576 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 gcg cgc cga gtt ccc ctg ggt cgg ctc gcg act gcc cga gag tcc gcg 624 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Ser Ala 195 200 205 ctg ctc gcg ttg ttc ctg gcc tcg gac gag agt gac ttc atc gtc ggc 672 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 aag tcg atc gag ttc gac ggc ggc tgg gcc acc tga 708 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 42 < 211 > 708 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 708 ) < 400 > 42 atg gct aac gga agg aaa agg gaa atg gct aac gga aga ctg gca ggc 48 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 aag cgg gtc cta ctc acg aac gcc gat gcc tac atg ggt gag gcc acg 96 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 gtc cag gtg ttc gag gag gag ggc gca gag gtc atc gct gac cac acc 144 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 gac ttg acg aag gtc ggc gcg gcg gag gag gtc gtc gag agg gct ggg 192 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 cac atc gat gtc ctg gtg gcc aac ttc gcg gtc gac gcc cac ttc ggg 240 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 gtg acc gtg ctg gag acc gac gag gag ctg tgg cag acg gcc tac gag 288 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 acc atc gtg cac ccg ctg cat cgg atc tgc cgt gcg gtg ctc ccg cag 336 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 ttc tac gag cgg aac aag ggc aag atc gtt gtc tac gga agt gcc gca 384 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 gcg atg cgg tac cag gaa ggt gcg ctg gcc tac agc acg gcg cgt ttc 432 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe 130 135 140 gct cag cgc ggg tac gtc acc gcc ctc ggt ccc gag gca gcg agg cac 480 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 aac gtc aac gtg aac ttc atc gcc cag cac tgg acc caa aac aag gag 528 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 tac ttc tgg ccc gag cgc atc gcc acc gac gag ttc aag gag gat atg 576 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 gcg cgc cga gtt ccc ctg ggt cgg ctc gcg act gcc cga gag act gcg 624 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Thr Ala 195 200 205 ctg ctc gcg ttg ttc ctg gcc tcg gac gag agt gac ttc atc gtc ggc 672 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 aag tcg atc gag ttc gac ggc ggc tgg gcc acc tga 708 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 43 < 211 > 708 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 708 ) < 400 > 43 atg gct aac gga agg aaa agg gaa atg gct aac gga aga ctg gca ggc 48 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 aag cgg gtc cta ctc acg aac gcc gat gcc tac atg ggt gag gcc acg 96 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 gtc cag gtg ttc gag gag gag ggc gca gag gtc atc gct gac cac acc 144 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 gac ttg acg aag gtc ggc gcg gcg gag gag gtc gtc gag agg gct ggg 192 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 cac atc gat gtc ctg gtg gcc aac ttc gcg gtc gac gcc cac ttc ggg 240 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 gtg acc gtg ctg gag acc gac gag gag ctg tgg cag acg gcc tac gag 288 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 acc atc gtg cac ccg ctg cat cgg atc tgc cgt gcg gtg ctc ccg cag 336 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 ttc tac gag cgg aac aag ggc aag atc gtt gtc tac gga agt gcc gca 384 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 gcg atg cgg tac cag gaa ggt gcg ctg gcc tac agc acg gcg cgt ttc 432 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe 130 135 140 gct cag cgc ggg tac gtc acc gcc ctc ggt ccc gag gca gcg agg cac 480 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 aac gtc aac gtg aac ttc atc gcc cag cac tgg acc caa aac aag gag 528 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 tac ttc tgg ccc gag cgc atc gcc acc gac gag ttc aag gag gat atg 576 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 gcg cgc cga gtt ccc ctg ggt cgg ctc gcg act gcc cga gag tat gcg 624 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Tyr Ala 195 200 205 ctg ctc gcg ttg ttc ctg gcc tcg gac gag agt gac ttc atc gtc ggc 672 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 aag tcg atc gag ttc gac ggc ggc tgg gcc acc tga 708 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 44 < 211 > 684 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 684 ) < 400 > 44 atg aaa aac gga aga ctg gca ggc aag cgg gtc cta ctc acg aac gcc 48 Met Lys Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 gat gcc tac atg ggt gag gcc acg gtc cag gtg ttc gag gag gag ggc 96 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 gca gag gtc atc gct gac cac acc gac ttg acg aag gtc ggc gcg gcg 144 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 gag gag gtc gtc gag agg gct ggg cac atc gat gtc ctg gtg gcc aac 192 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 ttc gcg gtc gac gcc cac ttc ggg gtg acc gtg ctg gag acc gac gag 240 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 gag ctg tgg cag acg gcc tac gag acc atc gtg cac ccg ctg cat cgg 288 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 atc tgc cgt gcg gtg ctc ccg cag ttc tac gag cgg aac aag ggc aag 336 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 atc gtt gtc tac gga agt gcc gca gcg atg cgg tac cag gaa ggt gcg 384 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 ctg gcc tac agc acg gcg cgt ttc gct cag cgc ggg tac gtc acc gcc 432 Leu Ala Tyr Ser Thr Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 ctc ggt ccc gag gca gcg agg cac aac gtc aac gtg aac ttc atc gcc 480 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 cag cac tgg acc caa aac aag gag tac ttc tgg ccc gag cgc atc gcc 528 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 acc gac gag ttc aag gag gat atg gcg cgc cga gtt ccc ctg ggt cgg 576 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 ctc gcg act gcc cga gag gac gcg ctg ctc gcg ttg ttc ctg gcc tcg 624 Leu Ala Thr Ala Arg Glu Asp Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 gac gag agt gac ttc atc gtc ggc aag tcg atc gag ttc gac ggc ggc 672 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 tgg gcc acc tga 684 Trp Ala Thr 225 < 210 > 45 < 211 > 684 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 684 ) < 400 > 45 atg aac aac gga aga ctg gca ggc aag cgg gtc cta ctc acg aac gcc 48 Met Asn Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 gat gcc tac atg ggt gag gcc acg gtc cag gtg ttc gag gag gag ggc 96 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 gca gag gtc atc gct gac cac acc gac ttg acg aag gtc ggc gcg gcg 144 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 gag gag gtc gtc gag agg gct ggg cac atc gat gtc ctg gtg gcc aac 192 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 ttc gcg gtc gac gcc cac ttc ggg gtg acc gtg ctg gag acc gac gag 240 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 gag ctg tgg cag acg gcc tac gag acc atc gtg cac ccg ctg cat cgg 288 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 atc tgc cgt gcg gtg ctc ccg cag ttc tac gag cgg aac aag ggc aag 336 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 atc gtt gtc tac gga agt gcc gca gcg atg cgg tac cag gaa ggt gcg 384 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 ctg gcc tac agc acg gcg cgt ttc gct cag cgc ggg tac gtc acc gcc 432 Leu Ala Tyr Ser Thr Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 ctc ggt ccc gag gca gcg agg cac aac gtc aac gtg aac ttc atc gcc 480 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 cag cac tgg acc caa aac aag gag tac ttc tgg ccc gag cgc atc gcc 528 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 acc gac gag ttc aag gag gat atg gcg cgc cga gtt ccc ctg ggt cgg 576 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 ctc gcg act gcc cga gag gac gcg ctg ctc gcg ttg ttc ctg gcc tcg 624 Leu Ala Thr Ala Arg Glu Asp Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 gac gag agt gac ttc atc gtc ggc aag tcg atc gag ttc gac ggc ggc 672 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 tgg gcc acc tga 684 Trp Ala Thr 225 < 210 > 46 < 211 > 684 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 684 ) < 400 > 46 atg gct aac gga aga ctg gca ggc aag cgg gtc cta ctc acg aac gcc 48 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 gat gcc tac atg ggt gag gcc acg gtc cag gtg ttc gag gag gag ggc 96 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 gca gag gtc atc gct gac cac acc gac ttg acg aag gtc ggc gcg gcg 144 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 gag gag gtc gtc gag agg gct ggg cac atc gat gtc ctg gtg gcc aac 192 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 ttc gcg gtc gac gcc cac ttc ggg gtg acc gtg ctg gag acc gac gag 240 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 gag ctg tgg cag acg gcc tac gag acc atc gtg cac ccg ctg cat cgg 288 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 atc tgc cgt gcg gtg ctc ccg cag ttc tac gag cgg aac aag ggc aag 336 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 atc gtt gtc tac gga agt gcc gca gcg atg cgg tac cag gaa ggt gcg 384 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 ctg gcc tac agc gcg gcg cgt ttc gct cag cgc ggg tac gtc acc gcc 432 Leu Ala Tyr Ser Ala Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 ctc ggt ccc gag gca gcg agg cac aac gtc aac gtg aac ttc atc gcc 480 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 cag cac tgg acc caa aac aag gag tac ttc tgg ccc gag cgc atc gcc 528 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 acc gac gag ttc aag gag gat atg gcg cgc cga gtt ccc ctg ggt cgg 576 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 ctc gcg act gcc cga gag gac gcg ctg ctc gcg ttg ttc ctg gcc tcg 624 Leu Ala Thr Ala Arg Glu Asp Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 gac gag agt gac ttc atc gtc ggc aag tcg atc gag ttc gac ggc ggc 672 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 tgg gcc acc tga 684 Trp Ala Thr 225 < 210 > 47 < 211 > 684 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 684 ) < 400 > 47 atg gct aac gga aga ctg gca ggc aag cgg gtc cta ctc acg aac gcc 48 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 gat gcc tac atg ggt gag gcc acg gtc cag gtg ttc gag gag gag ggc 96 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 gca gag gtc atc gct gac cac acc gac ttg acg aag gtc ggc gcg gcg 144 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 gag gag gtc gtc gag agg gct ggg cac atc gat gtc ctg gtg gcc aac 192 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 ttc gcg gtc gac gcc cac ttc ggg gtg acc gtg ctg gag acc gac gag 240 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 gag ctg tgg cag acg gcc tac gag acc atc gtg cac ccg ctg cat cgg 288 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 atc tgc cgt gcg gtg ctc ccg cag ttc tac gag cgg aac aag ggc aag 336 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 atc gtt gtc tac gga agt gcc gca gcg atg cgg tac cag gaa ggt gcg 384 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 ctg gcc tac agc tgt gcg cgt ttc gct cag cgc ggg tac gtc acc gcc 432 Leu Ala Tyr Ser Cys Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 ctc ggt ccc gag gca gcg agg cac aac gtc aac gtg aac ttc atc gcc 480 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 cag cac tgg acc caa aac aag gag tac ttc tgg ccc gag cgc atc gcc 528 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 acc gac gag ttc aag gag gat atg gcg cgc cga gtt ccc ctg ggt cgg 576 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 ctc gcg act gcc cga gag gac gcg ctg ctc gcg ttg ttc ctg gcc tcg 624 Leu Ala Thr Ala Arg Glu Asp Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 gac gag agt gac ttc atc gtc ggc aag tcg atc gag ttc gac ggc ggc 672 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 tgg gcc acc tga 684 Trp Ala Thr 225 < 210 > 48 < 211 > 684 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 684 ) < 400 > 48 atg gct aac gga aga ctg gca ggc aag cgg gtc cta ctc acg aac gcc 48 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 gat gcc tac atg ggt gag gcc acg gtc cag gtg ttc gag gag gag ggc 96 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 gca gag gtc atc gct gac cac acc gac ttg acg aag gtc ggc gcg gcg 144 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 gag gag gtc gtc gag agg gct ggg cac atc gat gtc ctg gtg gcc aac 192 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 ttc gcg gtc gac gcc cac ttc ggg gtg acc gtg ctg gag acc gac gag 240 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 gag ctg tgg cag acg gcc tac gag acc atc gtg cac ccg ctg cat cgg 288 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 atc tgc cgt gcg gtg ctc ccg cag ttc tac gag cgg aac aag ggc aag 336 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 atc gtt gtc tac gga agt gcc gca gcg atg cgg tac cag gaa ggt gcg 384 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 ctg gcc tac agc tct gcg cgt ttc gct cag cgc ggg tac gtc acc gcc 432 Leu Ala Tyr Ser Ser Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 ctc ggt ccc gag gca gcg agg cac aac gtc aac gtg aac ttc atc gcc 480 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 cag cac tgg acc caa aac aag gag tac ttc tgg ccc gag cgc atc gcc 528 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 acc gac gag ttc aag gag gat atg gcg cgc cga gtt ccc ctg ggt cgg 576 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 ctc gcg act gcc cga gag gac gcg ctg ctc gcg ttg ttc ctg gcc tcg 624 Leu Ala Thr Ala Arg Glu Asp Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 gac gag agt gac ttc atc gtc ggc aag tcg atc gag ttc gac ggc ggc 672 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 tgg gcc acc tga 684 Trp Ala Thr 225 < 210 > 49 < 211 > 684 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 684 ) < 400 > 49 atg gct aac gga aga ctg gca ggc aag cgg gtc cta ctc acg aac gcc 48 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 gat gcc tac atg ggt gag gcc acg gtc cag gtg ttc gag gag gag ggc 96 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 gca gag gtc atc gct gac cac acc gac ttg acg aag gtc ggc gcg gcg 144 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 gag gag gtc gtc gag agg gct ggg cac atc gat gtc ctg gtg gcc aac 192 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 ttc gcg gtc gac gcc cac ttc ggg gtg acc gtg ctg gag acc gac gag 240 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 gag ctg tgg cag acg gcc tac gag acc atc gtg cac ccg ctg cat cgg 288 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 atc tgc cgt gcg gtg ctc ccg cag ttc tac gag cgg aac aag ggc aag 336 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 atc gtt gtc tac gga agt gcc gca gcg atg cgg tac cag gaa ggt gcg 384 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 ctg gcc tac agc acg gcg cgt gcg gct cag cgc ggg tac gtc acc gcc 432 Leu Ala Tyr Ser Thr Ala Arg Ala Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 ctc ggt ccc gag gca gcg agg cac aac gtc aac gtg aac ttc atc gcc 480 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 cag cac tgg acc caa aac aag gag tac ttc tgg ccc gag cgc atc gcc 528 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 acc gac gag ttc aag gag gat atg gcg cgc cga gtt ccc ctg ggt cgg 576 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 ctc gcg act gcc cga gag gac gcg ctg ctc gcg ttg ttc ctg gcc tcg 624 Leu Ala Thr Ala Arg Glu Asp Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 gac gag agt gac ttc atc gtc ggc aag tcg atc gag ttc gac ggc ggc 672 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 tgg gcc acc tga 684 Trp Ala Thr 225 < 210 > 50 < 211 > 684 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 684 ) < 400 > 50 atg gct aac gga aga ctg gca ggc aag cgg gtc cta ctc acg aac gcc 48 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 gat gcc tac atg ggt gag gcc acg gtc cag gtg ttc gag gag gag ggc 96 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 gca gag gtc atc gct gac cac acc gac ttg acg aag gtc ggc gcg gcg 144 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 gag gag gtc gtc gag agg gct ggg cac atc gat gtc ctg gtg gcc aac 192 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 ttc gcg gtc gac gcc cac ttc ggg gtg acc gtg ctg gag acc gac gag 240 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 gag ctg tgg cag acg gcc tac gag acc atc gtg cac ccg ctg cat cgg 288 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 atc tgc cgt gcg gtg ctc ccg cag ttc tac gag cgg aac aag ggc aag 336 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 atc gtt gtc tac gga agt gcc gca gcg atg cgg tac cag gaa ggt gcg 384 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 ctg gcc tac agc acg gcg cgt tcc gct cag cgc ggg tac gtc acc gcc 432 Leu Ala Tyr Ser Thr Ala Arg Ser Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 ctc ggt ccc gag gca gcg agg cac aac gtc aac gtg aac ttc atc gcc 480 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 cag cac tgg acc caa aac aag gag tac ttc tgg ccc gag cgc atc gcc 528 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 acc gac gag ttc aag gag gat atg gcg cgc cga gtt ccc ctg ggt cgg 576 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 ctc gcg act gcc cga gag gac gcg ctg ctc gcg ttg ttc ctg gcc tcg 624 Leu Ala Thr Ala Arg Glu Asp Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 gac gag agt gac ttc atc gtc ggc aag tcg atc gag ttc gac ggc ggc 672 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 tgg gcc acc tga 684 Trp Ala Thr 225 < 210 > 51 < 211 > 684 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 684 ) < 400 > 51 atg gct aac gga aga ctg gca ggc aag cgg gtc cta ctc acg aac gcc 48 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 gat gcc tac atg ggt gag gcc acg gtc cag gtg ttc gag gag gag ggc 96 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 gca gag gtc atc gct gac cac acc gac ttg acg aag gtc ggc gcg gcg 144 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 gag gag gtc gtc gag agg gct ggg cac atc gat gtc ctg gtg gcc aac 192 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 ttc gcg gtc gac gcc cac ttc ggg gtg acc gtg ctg gag acc gac gag 240 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 gag ctg tgg cag acg gcc tac gag acc atc gtg cac ccg ctg cat cgg 288 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 atc tgc cgt gcg gtg ctc ccg cag ttc tac gag cgg aac aag ggc aag 336 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 atc gtt gtc tac gga agt gcc gca gcg atg cgg tac cag gaa ggt gcg 384 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 ctg gcc tac agc acg gcg cgt ttc gct cag cgc ggg tac gtc acc gcc 432 Leu Ala Tyr Ser Thr Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 ctc ggt ccc gag gca gcg agg cac aac gtc aac gtg aac ttc atc gcc 480 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 cag cac tgg acc caa aac aag gag tac ttc tgg ccc gag cgc atc gcc 528 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 acc gac gag ttc aag gag gat atg gcg cgc cga gtt ccc ctg ggt cgg 576 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 ctc gcg act gcc cga gag caa gcg ctg ctc gcg ttg ttc ctg gcc tcg 624 Leu Ala Thr Ala Arg Glu Gln Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 gac gag agt gac ttc atc gtc ggc aag tcg atc gag ttc gac ggc ggc 672 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 tgg gcc acc tga 684 Trp Ala Thr 225 < 210 > 52 < 211 > 684 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 684 ) < 400 > 52 atg gct aac gga aga ctg gca ggc aag cgg gtc cta ctc acg aac gcc 48 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 gat gcc tac atg ggt gag gcc acg gtc cag gtg ttc gag gag gag ggc 96 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 gca gag gtc atc gct gac cac acc gac ttg acg aag gtc ggc gcg gcg 144 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 gag gag gtc gtc gag agg gct ggg cac atc gat gtc ctg gtg gcc aac 192 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 ttc gcg gtc gac gcc cac ttc ggg gtg acc gtg ctg gag acc gac gag 240 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 gag ctg tgg cag acg gcc tac gag acc atc gtg cac ccg ctg cat cgg 288 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 atc tgc cgt gcg gtg ctc ccg cag ttc tac gag cgg aac aag ggc aag 336 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 atc gtt gtc tac gga agt gcc gca gcg atg cgg tac cag gaa ggt gcg 384 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 ctg gcc tac agc acg gcg cgt ttc gct cag cgc ggg tac gtc acc gcc 432 Leu Ala Tyr Ser Thr Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 ctc ggt ccc gag gca gcg agg cac aac gtc aac gtg aac ttc atc gcc 480 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 cag cac tgg acc caa aac aag gag tac ttc tgg ccc gag cgc atc gcc 528 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 acc gac gag ttc aag gag gat atg gcg cgc cga gtt ccc ctg ggt cgg 576 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 ctc gcg act gcc cga gag gag gcg ctg ctc gcg ttg ttc ctg gcc tcg 624 Leu Ala Thr Ala Arg Glu Glu Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 gac gag agt gac ttc atc gtc ggc aag tcg atc gag ttc gac ggc ggc 672 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 tgg gcc acc tga 684 Trp Ala Thr 225 < 210 > 53 < 211 > 684 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 684 ) < 400 > 53 atg gct aac gga aga ctg gca ggc aag cgg gtc cta ctc acg aac gcc 48 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 gat gcc tac atg ggt gag gcc acg gtc cag gtg ttc gag gag gag ggc 96 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 gca gag gtc atc gct gac cac acc gac ttg acg aag gtc ggc gcg gcg 144 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 gag gag gtc gtc gag agg gct ggg cac atc gat gtc ctg gtg gcc aac 192 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 ttc gcg gtc gac gcc cac ttc ggg gtg acc gtg ctg gag acc gac gag 240 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 gag ctg tgg cag acg gcc tac gag acc atc gtg cac ccg ctg cat cgg 288 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 atc tgc cgt gcg gtg ctc ccg cag ttc tac gag cgg aac aag ggc aag 336 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 atc gtt gtc tac gga agt gcc gca gcg atg cgg tac cag gaa ggt gcg 384 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 ctg gcc tac agc acg gcg cgt ttc gct cag cgc ggg tac gtc acc gcc 432 Leu Ala Tyr Ser Thr Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 ctc ggt ccc gag gca gcg agg cac aac gtc aac gtg aac ttc atc gcc 480 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 cag cac tgg acc caa aac aag gag tac ttc tgg ccc gag cgc atc gcc 528 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 acc gac gag ttc aag gag gat atg gcg cgc cga gtt ccc ctg ggt cgg 576 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 ctc gcg act gcc cga gag cac gcg ctg ctc gcg ttg ttc ctg gcc tcg 624 Leu Ala Thr Ala Arg Glu His Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 gac gag agt gac ttc atc gtc ggc aag tcg atc gag ttc gac ggc ggc 672 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 tgg gcc acc tga 684 Trp Ala Thr 225 < 210 > 54 < 211 > 684 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 684 ) < 400 > 54 atg gct aac gga aga ctg gca ggc aag cgg gtc cta ctc acg aac gcc 48 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 gat gcc tac atg ggt gag gcc acg gtc cag gtg ttc gag gag gag ggc 96 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 gca gag gtc atc gct gac cac acc gac ttg acg aag gtc ggc gcg gcg 144 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 gag gag gtc gtc gag agg gct ggg cac atc gat gtc ctg gtg gcc aac 192 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 ttc gcg gtc gac gcc cac ttc ggg gtg acc gtg ctg gag acc gac gag 240 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 gag ctg tgg cag acg gcc tac gag acc atc gtg cac ccg ctg cat cgg 288 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 atc tgc cgt gcg gtg ctc ccg cag ttc tac gag cgg aac aag ggc aag 336 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 atc gtt gtc tac gga agt gcc gca gcg atg cgg tac cag gaa ggt gcg 384 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 ctg gcc tac agc acg gcg cgt ttc gct cag cgc ggg tac gtc acc gcc 432 Leu Ala Tyr Ser Thr Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 ctc ggt ccc gag gca gcg agg cac aac gtc aac gtg aac ttc atc gcc 480 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 cag cac tgg acc caa aac aag gag tac ttc tgg ccc gag cgc atc gcc 528 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 acc gac gag ttc aag gag gat atg gcg cgc cga gtt ccc ctg ggt cgg 576 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 ctc gcg act gcc cga gag tcc gcg ctg ctc gcg ttg ttc ctg gcc tcg 624 Leu Ala Thr Ala Arg Glu Ser Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 gac gag agt gac ttc atc gtc ggc aag tcg atc gag ttc gac ggc ggc 672 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 tgg gcc acc tga 684 Trp Ala Thr 225 < 210 > 55 < 211 > 684 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 684 ) < 400 > 55 atg gct aac gga aga ctg gca ggc aag cgg gtc cta ctc acg aac gcc 48 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 gat gcc tac atg ggt gag gcc acg gtc cag gtg ttc gag gag gag ggc 96 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 gca gag gtc atc gct gac cac acc gac ttg acg aag gtc ggc gcg gcg 144 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 gag gag gtc gtc gag agg gct ggg cac atc gat gtc ctg gtg gcc aac 192 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 ttc gcg gtc gac gcc cac ttc ggg gtg acc gtg ctg gag acc gac gag 240 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 gag ctg tgg cag acg gcc tac gag acc atc gtg cac ccg ctg cat cgg 288 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 atc tgc cgt gcg gtg ctc ccg cag ttc tac gag cgg aac aag ggc aag 336 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 atc gtt gtc tac gga agt gcc gca gcg atg cgg tac cag gaa ggt gcg 384 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 ctg gcc tac agc acg gcg cgt ttc gct cag cgc ggg tac gtc acc gcc 432 Leu Ala Tyr Ser Thr Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 ctc ggt ccc gag gca gcg agg cac aac gtc aac gtg aac ttc atc gcc 480 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 cag cac tgg acc caa aac aag gag tac ttc tgg ccc gag cgc atc gcc 528 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 acc gac gag ttc aag gag gat atg gcg cgc cga gtt ccc ctg ggt cgg 576 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 ctc gcg act gcc cga gag act gcg ctg ctc gcg ttg ttc ctg gcc tcg 624 Leu Ala Thr Ala Arg Glu Thr Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 gac gag agt gac ttc atc gtc ggc aag tcg atc gag ttc gac ggc ggc 672 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 tgg gcc acc tga 684 Trp Ala Thr 225 < 210 > 56 < 211 > 684 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 684 ) < 400 > 56 atg gct aac gga aga ctg gca ggc aag cgg gtc cta ctc acg aac gcc 48 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 gat gcc tac atg ggt gag gcc acg gtc cag gtg ttc gag gag gag ggc 96 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 gca gag gtc atc gct gac cac acc gac ttg acg aag gtc ggc gcg gcg 144 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 gag gag gtc gtc gag agg gct ggg cac atc gat gtc ctg gtg gcc aac 192 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 ttc gcg gtc gac gcc cac ttc ggg gtg acc gtg ctg gag acc gac gag 240 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 gag ctg tgg cag acg gcc tac gag acc atc gtg cac ccg ctg cat cgg 288 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 atc tgc cgt gcg gtg ctc ccg cag ttc tac gag cgg aac aag ggc aag 336 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 atc gtt gtc tac gga agt gcc gca gcg atg cgg tac cag gaa ggt gcg 384 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 ctg gcc tac agc acg gcg cgt ttc gct cag cgc ggg tac gtc acc gcc 432 Leu Ala Tyr Ser Thr Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 ctc ggt ccc gag gca gcg agg cac aac gtc aac gtg aac ttc atc gcc 480 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 cag cac tgg acc caa aac aag gag tac ttc tgg ccc gag cgc atc gcc 528 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 acc gac gag ttc aag gag gat atg gcg cgc cga gtt ccc ctg ggt cgg 576 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 ctc gcg act gcc cga gag tat gcg ctg ctc gcg ttg ttc ctg gcc tcg 624 Leu Ala Thr Ala Arg Glu Tyr Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 gac gag agt gac ttc atc gtc ggc aag tcg atc gag ttc gac ggc ggc 672 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 tgg gcc acc tga 684 Trp Ala Thr 225 < 210 > 57 < 211 > 28 < 212 > DNA < 213 > Artificial < 220 > < 223 > Synthetic DNA < 400 > 57 ggccatggct aacggaagac tggcaggc 28 < 210 > 58 < 211 > 33 < 212 > DNA < 213 > Artificial < 220 > < 223 > Synthetic DNA < 400 > 58 gatcatgaaa aacggaagac tggcaggcaa gcg 33 < 210 > 59 < 211 > 33 < 212 > DNA < 213 > Artificial < 220 > < 223 > Synthetic DNA < 400 > 59 gatcatgaac aacggaagac tggcaggcaa gcg 33 < 210 > 60 < 211 > 32 < 212 > DNA < 213 > Artificial < 220 > < 223 > Synthetic DNA < 400 > 60 cgcctgcagg ctacaacgac gacgagcgcc tg 32 < 210 > 61 < 211 > 25 < 212 > DNA < 213 > Artificial < 220 > < 223 > Synthetic DNA < 400 > 61 ggctgaaaat cttctctcat ccgcc 25 < 210 > 62 < 211 > 29 < 212 > DNA < 213 > Artificial < 220 > < 223 > Synthetic DNA < 220 > < 221 > misc _ feature < 222 > ( 15 ) . .( 17 ) < 223 > n is a , c , g , or t < 400 > 62 cgctggccta cagcnnngcg cgtttcgct 29 < 210 > 63 < 211 > 29 < 212 > DNA < 213 > Artificial < 220 > < 223 > Synthetic DNA < 220 > < 221 > misc _ feature < 222 > ( 13 ) . .( 15 ) < 223 > n is a , c , g , or t < 400 > 63 agcgaaacgc gcnnngctgt aggccagcg 29 < 210 > 64 < 211 > 29 < 212 > DNA < 213 > Artificial < 220 > < 223 > Synthetic DNA < 220 > < 221 > misc _ feature < 222 > ( 14 ) . .( 16 ) < 223 > n is a , c , g , or t < 400 > 64 cagcacggcg cgtnnngctc agcgcgggt 29 < 210 > 65 < 211 > 29 < 212 > DNA < 213 > Artificial < 220 > < 223 > Synthetic DNA < 220 > < 221 > misc _ feature < 222 > ( 14 ) . .( 16 ) < 223 > n is a , c , g , or t < 400 > 65 acccgcgctg agcnnnacgc gccgtgctg 29 < 210 > 66 < 211 > 29 < 212 > DNA < 213 > Artificial < 220 > < 223 > Synthetic DNA < 220 > < 221 > misc _ feature < 222 > ( 15 ) . .( 17 ) < 223 > n is a , c , g , or t < 400 > 66 cgactgcccg agagnnngcg ctgctcgcg 29 < 210 > 67 < 211 > 29 < 212 > DNA < 213 > Artificial < 220 > < 223 > Synthetic DNA < 220 > < 221 > misc _ feature < 222 > ( 13 ) . .( 15 ) < 223 > n is a , c , g , or t < 400 > 67 cgcgagcagc gcnnnctctc gggcagtcg 29 < 210 > 68 < 211 > 29 < 212 > DNA < 213 > Artificial < 220 > < 223 > Synthetic DNA < 400 > 68 cgctggccta cagcgcggcg cgtttcgct 29 < 210 > 69 < 211 > 29 < 212 > DNA < 213 > Artificial < 220 > < 223 > Synthetic DNA < 400 > 69 agcgaaacgc gccgcgctgt aggccagcg 29 < 210 > 70 < 211 > 29 < 212 > DNA < 213 > Artificial < 220 > < 223 > Synthetic DNA < 400 > 70 cagcacggcg cgttccgctc agcgcgggt 29 < 210 > 71 < 211 > 29 < 212 > DNA < 213 > Artificial < 220 > < 223 > Synthetic DNA < 400 > 71 acccgcgctg agcggaacgc gccgtgctg 29 < 210 > 72 < 211 > 29 < 212 > DNA < 213 > Artificial < 220 > < 223 > Synthetic DNA < 400 > 72 cgactgcccg agagcacgcg ctgctcgcg 29 < 210 > 73 < 211 > 29 < 212 > DNA < 213 > Artificial < 220 > < 223 > Synthetic DNA < 400 > 73 cgcgagcagc gcgtgctctc gggcagtcg < 210 > 74 < 211 > 19 < 212 > PRT < 213 > Corynebacterium sp . < 220 > < 221 > misc _ feature < 222 > ( 2 ) . .( 13 ) < 223 > Xaa can be any naturally occurring amino acid < 220 > < 221 > misc _ feature < 222 > ( 15 ) . .( 16 ) < 223 > Xaa can be any naturally occurring amino acid < 220 > < 221 > misc _ feature < 222 > ( 19 ) . .( 19 ) < 223 > Xaa can be any naturally occurring amino acid < 400 > 74 Ser Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr Xaa Xaa 1 5 10 15 Ala Arg Xaa < 210 > 75 < 211 > 10 < 212 > PRT < 213 > Corynebacterium sp . < 220 > < 221 > misc _ feature < 222 > ( 2 ) . .( 2 ) < 223 > Xaa can be any naturally occurring amino acid < 220 > < 221 > misc _ feature < 222 > ( 5 ) . .( 8 ) < 223 > Xaa can be any naturally occurring amino acid < 220 > < 221 > misc _ feature < 222 > ( 10 ) . .( 10 ) < 223 > Xaa can be any naturally occurring amino acid < 400 > 75 Leu Xaa Arg Leu Xaa Xaa Xaa Xaa Glu Xaa 1 5 10 < 210 > 76 < 211 > 235 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 76 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Trp 130 135 140 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Asp Ala 195 200 205 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 77 < 211 > 235 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 77 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe 130 135 140 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Leu Ala 195 200 205 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 78 < 211 > 235 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 78 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe 130 135 140 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Met Ala 195 200 205 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 79 < 211 > 235 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 79 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe 130 135 140 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Ile Ala 195 200 205 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 80 < 211 > 227 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 80 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 Leu Ala Tyr Ser Thr Ala Arg Trp Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 Leu Ala Thr Ala Arg Glu Asp Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 Trp Ala Thr 225 < 210 > 81 < 211 > 227 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 81 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 Leu Ala Tyr Ser Thr Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 Leu Ala Thr Ala Arg Glu Leu Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 Trp Ala Thr 225 < 210 > 82 < 211 > 227 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 82 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 Leu Ala Tyr Ser Thr Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 Leu Ala Thr Ala Arg Glu Met Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 Trp Ala Thr 225 < 210 > 83 < 211 > 227 < 212 > PRT < 213 > Artificial < 220 > < 223 > Variant peptide < 400 > 83 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 Leu Ala Tyr Ser Thr Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 Leu Ala Thr Ala Arg Glu Ile Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 Trp Ala Thr 225 < 210 > 84 < 211 > 708 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 708 ) < 400 > 84 atg gct aac gga agg aaa agg gaa atg gct aac gga aga ctg gca ggc 48 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 aag cgg gtc cta ctc acg aac gcc gat gcc tac atg ggt gag gcc acg 96 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 gtc cag gtg ttc gag gag gag ggc gca gag gtc atc gct gac cac acc 144 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 gac ttg acg aag gtc ggc gcg gcg gag gag gtc gtc gag agg gct ggg 192 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 cac atc gat gtc ctg gtg gcc aac ttc gcg gtc gac gcc cac ttc ggg 240 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 gtg acc gtg ctg gag acc gac gag gag ctg tgg cag acg gcc tac gag 288 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 acc atc gtg cac ccg ctg cat cgg atc tgc cgt gcg gtg ctc ccg cag 336 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 ttc tac gag cgg aac aag ggc aag atc gtt gtc tac gga agt gcc gca 384 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 gcg atg cgg tac cag gaa ggt gcg ctg gcc tac agc acg gcg cgt tgg 432 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Trp 130 135 140 gct cag cgc ggg tac gtc acc gcc ctc ggt ccc gag gca gcg agg cac 480 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 aac gtc aac gtg aac ttc atc gcc cag cac tgg acc caa aac aag gag 528 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 tac ttc tgg ccc gag cgc atc gcc acc gac gag ttc aag gag gat atg 576 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 gcg cgc cga gtt ccc ctg ggt cgg ctc gcg act gcc cga gag gac gcg 624 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Asp Ala 195 200 205 ctg ctc gcg ttg ttc ctg gcc tcg gac gag agt gac ttc atc gtc ggc 672 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 aag tcg atc gag ttc gac ggc ggc tgg gcc acc tga 708 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 85 < 211 > 708 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 708 ) < 400 > 85 atg gct aac gga agg aaa agg gaa atg gct aac gga aga ctg gca ggc 48 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 aag cgg gtc cta ctc acg aac gcc gat gcc tac atg ggt gag gcc acg 96 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 gtc cag gtg ttc gag gag gag ggc gca gag gtc atc gct gac cac acc 144 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 gac ttg acg aag gtc ggc gcg gcg gag gag gtc gtc gag agg gct ggg 192 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 cac atc gat gtc ctg gtg gcc aac ttc gcg gtc gac gcc cac ttc ggg 240 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 gtg acc gtg ctg gag acc gac gag gag ctg tgg cag acg gcc tac gag 288 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 acc atc gtg cac ccg ctg cat cgg atc tgc cgt gcg gtg ctc ccg cag 336 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 ttc tac gag cgg aac aag ggc aag atc gtt gtc tac gga agt gcc gca 384 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 gcg atg cgg tac cag gaa ggt gcg ctg gcc tac agc acg gcg cgt ttc 432 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe 130 135 140 gct cag cgc ggg tac gtc acc gcc ctc ggt ccc gag gca gcg agg cac 480 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 aac gtc aac gtg aac ttc atc gcc cag cac tgg acc caa aac aag gag 528 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 tac ttc tgg ccc gag cgc atc gcc acc gac gag ttc aag gag gat atg 576 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 gcg cgc cga gtt ccc ctg ggt cgg ctc gcg act gcc cga gag ctg gcg 624 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Leu Ala 195 200 205 ctg ctc gcg ttg ttc ctg gcc tcg gac gag agt gac ttc atc gtc ggc 672 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 aag tcg atc gag ttc gac ggc ggc tgg gcc acc tga 708 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 86 < 211 > 708 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 708 ) < 400 > 86 atg gct aac gga agg aaa agg gaa atg gct aac gga aga ctg gca ggc 48 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 aag cgg gtc cta ctc acg aac gcc gat gcc tac atg ggt gag gcc acg 96 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 gtc cag gtg ttc gag gag gag ggc gca gag gtc atc gct gac cac acc 144 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 gac ttg acg aag gtc ggc gcg gcg gag gag gtc gtc gag agg gct ggg 192 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 cac atc gat gtc ctg gtg gcc aac ttc gcg gtc gac gcc cac ttc ggg 240 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 gtg acc gtg ctg gag acc gac gag gag ctg tgg cag acg gcc tac gag 288 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 acc atc gtg cac ccg ctg cat cgg atc tgc cgt gcg gtg ctc ccg cag 336 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 ttc tac gag cgg aac aag ggc aag atc gtt gtc tac gga agt gcc gca 384 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 gcg atg cgg tac cag gaa ggt gcg ctg gcc tac agc acg gcg cgt ttc 432 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe 130 135 140 gct cag cgc ggg tac gtc acc gcc ctc ggt ccc gag gca gcg agg cac 480 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 aac gtc aac gtg aac ttc atc gcc cag cac tgg acc caa aac aag gag 528 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 tac ttc tgg ccc gag cgc atc gcc acc gac gag ttc aag gag gat atg 576 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 gcg cgc cga gtt ccc ctg ggt cgg ctc gcg act gcc cga gag atg gcg 624 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Met Ala 195 200 205 ctg ctc gcg ttg ttc ctg gcc tcg gac gag agt gac ttc atc gtc ggc 672 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 aag tcg atc gag ttc gac ggc ggc tgg gcc acc tga 708 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 87 < 211 > 708 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 708 ) < 400 > 87 atg gct aac gga agg aaa agg gaa atg gct aac gga aga ctg gca ggc 48 Met Ala Asn Gly Arg Lys Arg Glu Met Ala Asn Gly Arg Leu Ala Gly 1 5 10 15 aag cgg gtc cta ctc acg aac gcc gat gcc tac atg ggt gag gcc acg 96 Lys Arg Val Leu Leu Thr Asn Ala Asp Ala Tyr Met Gly Glu Ala Thr 20 25 30 gtc cag gtg ttc gag gag gag ggc gca gag gtc atc gct gac cac acc 144 Val Gln Val Phe Glu Glu Glu Gly Ala Glu Val Ile Ala Asp His Thr 35 40 45 gac ttg acg aag gtc ggc gcg gcg gag gag gtc gtc gag agg gct ggg 192 Asp Leu Thr Lys Val Gly Ala Ala Glu Glu Val Val Glu Arg Ala Gly 50 55 60 cac atc gat gtc ctg gtg gcc aac ttc gcg gtc gac gcc cac ttc ggg 240 His Ile Asp Val Leu Val Ala Asn Phe Ala Val Asp Ala His Phe Gly 65 70 75 80 gtg acc gtg ctg gag acc gac gag gag ctg tgg cag acg gcc tac gag 288 Val Thr Val Leu Glu Thr Asp Glu Glu Leu Trp Gln Thr Ala Tyr Glu 85 90 95 acc atc gtg cac ccg ctg cat cgg atc tgc cgt gcg gtg ctc ccg cag 336 Thr Ile Val His Pro Leu His Arg Ile Cys Arg Ala Val Leu Pro Gln 100 105 110 ttc tac gag cgg aac aag ggc aag atc gtt gtc tac gga agt gcc gca 384 Phe Tyr Glu Arg Asn Lys Gly Lys Ile Val Val Tyr Gly Ser Ala Ala 115 120 125 gcg atg cgg tac cag gaa ggt gcg ctg gcc tac agc acg gcg cgt ttc 432 Ala Met Arg Tyr Gln Glu Gly Ala Leu Ala Tyr Ser Thr Ala Arg Phe 130 135 140 gct cag cgc ggg tac gtc acc gcc ctc ggt ccc gag gca gcg agg cac 480 Ala Gln Arg Gly Tyr Val Thr Ala Leu Gly Pro Glu Ala Ala Arg His 145 150 155 160 aac gtc aac gtg aac ttc atc gcc cag cac tgg acc caa aac aag gag 528 Asn Val Asn Val Asn Phe Ile Ala Gln His Trp Thr Gln Asn Lys Glu 165 170 175 tac ttc tgg ccc gag cgc atc gcc acc gac gag ttc aag gag gat atg 576 Tyr Phe Trp Pro Glu Arg Ile Ala Thr Asp Glu Phe Lys Glu Asp Met 180 185 190 gcg cgc cga gtt ccc ctg ggt cgg ctc gcg act gcc cga gag atc gcg 624 Ala Arg Arg Val Pro Leu Gly Arg Leu Ala Thr Ala Arg Glu Ile Ala 195 200 205 ctg ctc gcg ttg ttc ctg gcc tcg gac gag agt gac ttc atc gtc ggc 672 Leu Leu Ala Leu Phe Leu Ala Ser Asp Glu Ser Asp Phe Ile Val Gly 210 215 220 aag tcg atc gag ttc gac ggc ggc tgg gcc acc tga 708 Lys Ser Ile Glu Phe Asp Gly Gly Trp Ala Thr 225 230 235 < 210 > 88 < 211 > 684 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 684 ) < 400 > 88 atg gct aac gga aga ctg gca ggc aag cgg gtc cta ctc acg aac gcc 48 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 gat gcc tac atg ggt gag gcc acg gtc cag gtg ttc gag gag gag ggc 96 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 gca gag gtc atc gct gac cac acc gac ttg acg aag gtc ggc gcg gcg 144 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 gag gag gtc gtc gag agg gct ggg cac atc gat gtc ctg gtg gcc aac 192 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 ttc gcg gtc gac gcc cac ttc ggg gtg acc gtg ctg gag acc gac gag 240 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 gag ctg tgg cag acg gcc tac gag acc atc gtg cac ccg ctg cat cgg 288 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 atc tgc cgt gcg gtg ctc ccg cag ttc tac gag cgg aac aag ggc aag 336 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 atc gtt gtc tac gga agt gcc gca gcg atg cgg tac cag gaa ggt gcg 384 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 ctg gcc tac agc acg gcg cgt tgg gct cag cgc ggg tac gtc acc gcc 432 Leu Ala Tyr Ser Thr Ala Arg Trp Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 ctc ggt ccc gag gca gcg agg cac aac gtc aac gtg aac ttc atc gcc 480 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 cag cac tgg acc caa aac aag gag tac ttc tgg ccc gag cgc atc gcc 528 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 acc gac gag ttc aag gag gat atg gcg cgc cga gtt ccc ctg ggt cgg 576 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 ctc gcg act gcc cga gag gac gcg ctg ctc gcg ttg ttc ctg gcc tcg 624 Leu Ala Thr Ala Arg Glu Asp Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 gac gag agt gac ttc atc gtc ggc aag tcg atc gag ttc gac ggc ggc 672 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 tgg gcc acc tga 684 Trp Ala Thr 225 < 210 > 89 < 211 > 684 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 684 ) < 400 > 89 atg gct aac gga aga ctg gca ggc aag cgg gtc cta ctc acg aac gcc 48 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 gat gcc tac atg ggt gag gcc acg gtc cag gtg ttc gag gag gag ggc 96 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 gca gag gtc atc gct gac cac acc gac ttg acg aag gtc ggc gcg gcg 144 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 gag gag gtc gtc gag agg gct ggg cac atc gat gtc ctg gtg gcc aac 192 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 ttc gcg gtc gac gcc cac ttc ggg gtg acc gtg ctg gag acc gac gag 240 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 gag ctg tgg cag acg gcc tac gag acc atc gtg cac ccg ctg cat cgg 288 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 atc tgc cgt gcg gtg ctc ccg cag ttc tac gag cgg aac aag ggc aag 336 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 atc gtt gtc tac gga agt gcc gca gcg atg cgg tac cag gaa ggt gcg 384 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 ctg gcc tac agc acg gcg cgt ttc gct cag cgc ggg tac gtc acc gcc 432 Leu Ala Tyr Ser Thr Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 ctc ggt ccc gag gca gcg agg cac aac gtc aac gtg aac ttc atc gcc 480 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 cag cac tgg acc caa aac aag gag tac ttc tgg ccc gag cgc atc gcc 528 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 acc gac gag ttc aag gag gat atg gcg cgc cga gtt ccc ctg ggt cgg 576 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 ctc gcg act gcc cga gag ctg gcg ctg ctc gcg ttg ttc ctg gcc tcg 624 Leu Ala Thr Ala Arg Glu Leu Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 gac gag agt gac ttc atc gtc ggc aag tcg atc gag ttc gac ggc ggc 672 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 tgg gcc acc tga 684 Trp Ala Thr 225 < 210 > 90 < 211 > 684 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 684 ) < 400 > 90 atg gct aac gga aga ctg gca ggc aag cgg gtc cta ctc acg aac gcc 48 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 gat gcc tac atg ggt gag gcc acg gtc cag gtg ttc gag gag gag ggc 96 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 gca gag gtc atc gct gac cac acc gac ttg acg aag gtc ggc gcg gcg 144 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 gag gag gtc gtc gag agg gct ggg cac atc gat gtc ctg gtg gcc aac 192 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 ttc gcg gtc gac gcc cac ttc ggg gtg acc gtg ctg gag acc gac gag 240 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 gag ctg tgg cag acg gcc tac gag acc atc gtg cac ccg ctg cat cgg 288 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 atc tgc cgt gcg gtg ctc ccg cag ttc tac gag cgg aac aag ggc aag 336 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 atc gtt gtc tac gga agt gcc gca gcg atg cgg tac cag gaa ggt gcg 384 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 ctg gcc tac agc acg gcg cgt ttc gct cag cgc ggg tac gtc acc gcc 432 Leu Ala Tyr Ser Thr Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 ctc ggt ccc gag gca gcg agg cac aac gtc aac gtg aac ttc atc gcc 480 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 cag cac tgg acc caa aac aag gag tac ttc tgg ccc gag cgc atc gcc 528 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 acc gac gag ttc aag gag gat atg gcg cgc cga gtt ccc ctg ggt cgg 576 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 ctc gcg act gcc cga gag atg gcg ctg ctc gcg ttg ttc ctg gcc tcg 624 Leu Ala Thr Ala Arg Glu Met Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 gac gag agt gac ttc atc gtc ggc aag tcg atc gag ttc gac ggc ggc 672 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 tgg gcc acc tga 684 Trp Ala Thr 225 < 210 > 91 < 211 > 684 < 212 > DNA < 213 > Artificial < 220 > < 223 > Variant DNA < 220 > < 221 > CDS < 222 > ( 1 ) . .( 684 ) < 400 > 91 atg gct aac gga aga ctg gca ggc aag cgg gtc cta ctc acg aac gcc 48 Met Ala Asn Gly Arg Leu Ala Gly Lys Arg Val Leu Leu Thr Asn Ala 1 5 10 15 gat gcc tac atg ggt gag gcc acg gtc cag gtg ttc gag gag gag ggc 96 Asp Ala Tyr Met Gly Glu Ala Thr Val Gln Val Phe Glu Glu Glu Gly 20 25 30 gca gag gtc atc gct gac cac acc gac ttg acg aag gtc ggc gcg gcg 144 Ala Glu Val Ile Ala Asp His Thr Asp Leu Thr Lys Val Gly Ala Ala 35 40 45 gag gag gtc gtc gag agg gct ggg cac atc gat gtc ctg gtg gcc aac 192 Glu Glu Val Val Glu Arg Ala Gly His Ile Asp Val Leu Val Ala Asn 50 55 60 ttc gcg gtc gac gcc cac ttc ggg gtg acc gtg ctg gag acc gac gag 240 Phe Ala Val Asp Ala His Phe Gly Val Thr Val Leu Glu Thr Asp Glu 65 70 75 80 gag ctg tgg cag acg gcc tac gag acc atc gtg cac ccg ctg cat cgg 288 Glu Leu Trp Gln Thr Ala Tyr Glu Thr Ile Val His Pro Leu His Arg 85 90 95 atc tgc cgt gcg gtg ctc ccg cag ttc tac gag cgg aac aag ggc aag 336 Ile Cys Arg Ala Val Leu Pro Gln Phe Tyr Glu Arg Asn Lys Gly Lys 100 105 110 atc gtt gtc tac gga agt gcc gca gcg atg cgg tac cag gaa ggt gcg 384 Ile Val Val Tyr Gly Ser Ala Ala Ala Met Arg Tyr Gln Glu Gly Ala 115 120 125 ctg gcc tac agc acg gcg cgt ttc gct cag cgc ggg tac gtc acc gcc 432 Leu Ala Tyr Ser Thr Ala Arg Phe Ala Gln Arg Gly Tyr Val Thr Ala 130 135 140 ctc ggt ccc gag gca gcg agg cac aac gtc aac gtg aac ttc atc gcc 480 Leu Gly Pro Glu Ala Ala Arg His Asn Val Asn Val Asn Phe Ile Ala 145 150 155 160 cag cac tgg acc caa aac aag gag tac ttc tgg ccc gag cgc atc gcc 528 Gln His Trp Thr Gln Asn Lys Glu Tyr Phe Trp Pro Glu Arg Ile Ala 165 170 175 acc gac gag ttc aag gag gat atg gcg cgc cga gtt ccc ctg ggt cgg 576 Thr Asp Glu Phe Lys Glu Asp Met Ala Arg Arg Val Pro Leu Gly Arg 180 185 190 ctc gcg act gcc cga gag atc gcg ctg ctc gcg ttg ttc ctg gcc tcg 624 Leu Ala Thr Ala Arg Glu Ile Ala Leu Leu Ala Leu Phe Leu Ala Ser 195 200 205 gac gag agt gac ttc atc gtc ggc aag tcg atc gag ttc gac ggc ggc 672 Asp Glu Ser Asp Phe Ile Val Gly Lys Ser Ile Glu Phe Asp Gly Gly 210 215 220 tgg gcc acc tga 684 Trp Ala Thr 225