Mander , R . , Wu , C , Sausville , E . A . , Roettinger , AJ . , Newman , DJ . , Ho , D . K . , King , R . , Yang , D . , Lippman , M . E . , Landolfi , N . F . , Dadachova , E . , Brechbiel , M . W . and Waldman , T . A . ( 2000 ) Immunoconjugates of geldanamycin and anti - HER 2 monoclonal antibodies : antiproliferative activity on human breast carcinoma cell lines . Journal of the National Cancer Institute 92 : 1573 - 1581 .