저자 명 : Jieying Wang , Taomin Bai , Nana Wang , Hongyan Li , Xiangyang Guo 
 간행물 정보 : 『 The Korean Journal of Physiology & Pharmacology 』 24 권 1 호 , 11 ~ 18 쪽 , 전체 8 쪽 
 Jieying Wang , Taomin Bai , Nana Wang , Hongyan Li , Xiangyang Guo . ( 2020 ) . Neuroprotective potential of imatinib in global ischemiareperfusion - induced cerebral injury : possible role of Janus - activated kinase 2 / signal transducer and activator of transcription 3 and connexin 43 . The Korean Journal of Physiology & Pharmacology , 24 ( 1 ) , 11 - 18 . 
 Jieying Wang , Taomin Bai , Nana Wang , Hongyan Li , Xiangyang Guo . " Neuroprotective potential of imatinib in global ischemiareperfusion - induced cerebral injury : possible role of Janus - activated kinase 2 / signal transducer and activator of transcription 3 and connexin 43 . " The Korean Journal of Physiology & Pharmacology , 24 . 1 ( 2020 ) : 11 - 18 . 
 The present study was aimed to explore the neuroprotective role of imatinib in global ischemia - reperfusion - induced cerebral injury along with possible mechanisms . Global ischemia was induced in mice by bilateral carotid artery occlusion for 20 min , which was followed by reperfusion for 24 h by restoring the blood flow to the brain . The extent of cerebral injury was assessed after 24 h of global ischemia by measuring the locomotor activity ( actophotometer test ) , motor coordination ( inclined beam walking test ) , neurological severity score , learning and memory ( object recognition test ) and cerebral infarction ( triphenyl tetrazolium chloride stain ) . 
 Ischemia - reperfusion injury produced significant cerebral infarction , impaired the behavioral parameters and decreased the expression of connexin 43 and phosphorylated signal transducer and activator of transcription 3 ( p - STAT 3 ) in the brain . A single dose administration of imatinib ( 20 and 40 mg / kg ) attenuated ischemia - reperfusioninduced behavioral deficits and the extent of cerebral infarction along with the restoration of connexin 43 and p - STAT 3 levels . However , administration of AG 490 , a selective Janus - activated kinase 2 ( JAK 2 ) / STAT 3 inhibitor , abolished the neuroprotective actions of imatinib and decreased the expression of connexin 43 and p - STAT 3 . It is concluded that imatinib has the potential of attenuating global ischemia - reperfusion - induced cerebral injury , which may be possibly attributed to activation of JAK 2 / STAT 3 signaling pathway along with the increase in the expression of connexin 43 . 
 1 배양 에 따른 심장근 육 세포 의 박동 과 세포 사이 결합 의 변화 
 2 요도 부분 폐색 에 의한 흰쥐 방광 근 의 변화 
 3 심장근 육 세포 에서 사이 원반 형성 에 따른 Connexin 43 과 Pan - cadherin 의 분포 
 4 Spatial relationship between expression of cytokeratin - 19 and that of connexin - 43 in human fetal kidney 
 5 Effects of heme oxygenase - 1 upregulation on isoproterenolinduced myocardial infarction