< 110 > SCANCELL LIMITED < 120 > NUCLEIC ACIDS < 130 > IPA 090368 - GB - D 1 < 150 > GB 0706070 . 0 < 151 > 2007 - 03 - 28 < 160 > 247 < 170 > PatentIn version 3 . 3 < 210 > 1 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > I - Ad restricted epitope from Influenza haemagluttinin < 400 > 1 Phe Glu Arg Phe Glu Ile Phe Pro Lys Glu 1 5 10 < 210 > 2 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Tie - 2 Z 84 epitope < 400 > 2 Phe Leu Pro Ala Thr Leu Thr Met Val 1 5 < 210 > 3 < 211 > 18 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HLA - DR 7 restricted gp 100 CD 4 epitope < 400 > 3 Gly Thr Gly Arg Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val 1 5 10 15 Tyr His < 210 > 4 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Tie - 2 Z 12 epitope < 400 > 4 Ile Leu Ile Asn Ser Leu Pro Leu Val 1 5 < 210 > 5 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HLA - A 2 restricted gp 100 epitope < 400 > 5 Ile Met Asp Gln Val Pro Phe Ser Val 1 5 < 210 > 6 < 211 > 12 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HepB S Ag epitope < 400 > 6 Ile Pro Gln Ser Leu Asp Ser Trp Trp Thr Ser Leu 1 5 10 < 210 > 7 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > gp 100 wt ITDQVPFSV epitope < 400 > 7 Ile Thr Asp Gln Val Pro Phe Ser Val 1 5 < 210 > 8 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > ovalbumin epitope < 400 > 8 Ser Ile Ile Asn Phe Glu Lys Leu 1 5 < 210 > 9 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > TRP 2 epitope < 400 > 9 Ser Val Tyr Asp Phe Phe Val Trp Leu 1 5 < 210 > 10 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > GP 100 wild type / GP 100210 M epitope < 400 > 10 Thr Ile Thr Asp Gln Val Pro Phe Ser Val 1 5 10 < 210 > 11 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > GP 100 F 7 I epitope < 400 > 11 Thr Ile Thr Asp Gln Val Pro Ile Ser Val 1 5 10 < 210 > 12 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > GP 100 F 7 L epitope < 400 > 12 Thr Ile Thr Asp Gln Val Pro Leu Ser Val 1 5 10 < 210 > 13 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > GP 100 F 7 Y epitope < 400 > 13 Thr Ile Thr Asp Gln Val Pro Tyr Ser Val 1 5 10 < 210 > 14 < 211 > 13 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > I - Ab restricted epitope / HepB CD 4 epitope < 400 > 14 Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu 1 5 10 < 210 > 15 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HLA - DR 4 restricted gp 100 CD 4 epitope < 400 > 15 Trp Asn Arg Gln Leu Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp 1 5 10 15 < 210 > 16 < 211 > 14 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Chosen enzyme site ( Fsp I ) and epitope oligonucleotide sequence for CDR H 1 < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 6 ) < 223 > Epitope DNA sequence < 400 > 16 nnnnnntggg ttcg 14 < 210 > 17 < 211 > 14 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Chosen enzyme site ( Msc I ) and epitope oligonucleotide sequence for CDR H 2 < 220 > < 221 > misc _ feature < 222 > ( 2 ) . .( 7 ) < 223 > n is a , c , g , or t < 400 > 17 tnnnnnncga ttca 14 < 210 > 18 < 211 > 10 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Chosen enzyme site ( Srf I ) and epitope oligonucleotide sequence for CDR H 3 < 220 > < 221 > misc _ feature < 222 > ( 3 ) . .( 8 ) < 223 > n is a , c , g , or t < 400 > 18 gannnnnntg 10 < 210 > 19 < 211 > 17 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Chosen enzyme site ( Eco RV ) and epitope oligonucleotide sequence for CDR L 1 < 220 > < 221 > misc _ feature < 222 > ( 8 ) . .( 13 ) < 223 > n is a , c , g , or t < 400 > 19 ctcttgcnnn nnntggt 17 < 210 > 20 < 211 > 12 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Chosen enzyme site ( Ssp I ) and epitope oligonucleotide sequence for CDR L 2 < 220 > < 221 > misc _ feature < 222 > ( 5 ) . .( 10 ) < 223 > n is a , c , g , or t < 400 > 20 ctacnnnnnn ag 12 < 210 > 21 < 211 > 26 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Chosen enzyme site ( Hpa I ) and epitope oligonucleotide sequence for CDR L 3 < 220 > < 221 > misc _ feature < 222 > ( 10 ) . .( 15 ) < 223 > n is a , c , g , or t < 400 > 21 tattactgcn nnnnnttcgg tggagg 26 < 210 > 22 < 211 > 35 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer H 1 < 400 > 22 cctgagaatg tcctgctgcg caggctccgg ggaag 35 < 210 > 23 < 211 > 29 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer H 2 < 400 > 23 cattggtagt ggtggccatt tccagagac 29 < 210 > 24 < 211 > 37 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer H 3 < 400 > 24 ccgtgtatta ctgtgcccgg gccaaggaac cacggtc 37 < 210 > 25 < 211 > 32 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer L 1 < 400 > 25 ggagccagcc tcgatatctg cagaaaccag gc 32 < 210 > 26 < 211 > 32 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer L 2 < 400 > 26 ccacagctcc taatattcag tggcagtgga tc 32 < 210 > 27 < 211 > 33 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer L 3 < 400 > 27 gctgaggata ccggagttaa ccaaggtgga aat 33 < 210 > 28 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer huHeClonR < 400 > 28 cgcctgagtt ccacgacacc 20 < 210 > 29 < 211 > 18 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer huLiClonR < 400 > 29 caggcacaca acagaggc 18 < 210 > 30 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer CMV Forward < 400 > 30 ggcgtggata gcggtttgac 20 < 210 > 31 < 211 > 39 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer OrigstophuHeCH 1 For < 400 > 31 ccaaggtgga caagaaagtt tgacccaaat cttgtgaca 39 < 210 > 32 < 211 > 45 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer OrigstophuHeCH 1 Rev < 400 > 32 gagttttgtc acaagatttg ggtcaaactt tcttgtccac cttgg 45 < 210 > 33 < 211 > 29 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer pOrig light no leader For < 400 > 33 aggatccacc atggatgtgt tgatgaccc 29 < 210 > 34 < 211 > 25 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer pOrig heavy no leader For < 400 > 34 aaagcttatg caggtgcagc tggtg 25 < 210 > 35 < 211 > 26 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer huigG 3 rev 2 # < 400 > 35 atcgatatca tttacccgga gacagg 26 < 210 > 36 < 211 > 24 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer IgG 3 hufor 2 < 400 > 36 actgtctcca gcgcttccac caag 24 < 210 > 37 < 211 > 24 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer IgG 2 for < 400 > 37 agtcaccgtt tccagcgctt ccac 24 < 210 > 38 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer IgG 2 rev < 400 > 38 agtggatatc atttacccgg agacagg 27 < 210 > 39 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer HIBF < 400 > 39 aacagtctga gggctgagga 20 < 210 > 40 < 211 > 34 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer huigG 1 PVA REV < 400 > 40 agactgacgg tccccccgcg actggaggtg ctgg 34 < 210 > 41 < 211 > 34 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer HuigG 2 ELLGRev < 400 > 41 agactgacgg tcctcctaac agttctggtg ctgg 34 < 210 > 42 < 211 > 34 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer SV 40 premFOR < 400 > 42 agctagcatc agcacgtgtt gacaattaat catc 34 < 210 > 43 < 211 > 28 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer SV 40 premREV < 400 > 43 aacgattccg aagcccaacc tttcatag 28 < 210 > 44 < 211 > 32 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer migG 2 aC 1 Afe 1 F 2 < 400 > 44 tttacagcgc taaaacaaca gccccatcgg tc 32 < 210 > 45 < 211 > 34 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer migG 2 aXbaRA < 400 > 45 tctagatcat ttacccggag tccgggagaa gctc 34 < 210 > 46 < 211 > 30 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer MoLC 1 BsiF 1 < 400 > 46 tttcgtacgg atgctgcacc aactgtatcc 30 < 210 > 47 < 211 > 32 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer MoLCXhoR 1 < 400 > 47 tttctcgagt caacactcat tcctgttgaa gc 32 < 210 > 48 < 211 > 36 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer MoIgG 2 BamHI For < 400 > 48 ccttgacctg gaactctggt tccctgtcca gtggtg 36 < 210 > 49 < 211 > 36 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer MoigG 2 BamHI Rev < 400 > 49 caccactgga cagggaacca gagttccagg tcaagg 36 < 210 > 50 < 211 > 38 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer MoigG 2 XhoI For < 400 > 50 gcagctcagt gactgtaact tcgagcacct ggcccagc 38 < 210 > 51 < 211 > 38 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer MoigG 2 XhoI Rev < 400 > 51 gctgggccag gtgctcgaag ttacagtcac tgagctgc 38 < 210 > 52 < 211 > 59 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer wtkappavarL 1 for < 400 > 52 ctcttgcaga tctagtcaga gcctggtaca tagtaatgga aacacctatt tagaatggt 59 < 210 > 53 < 211 > 59 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer wtkappavarL 1 rev < 400 > 53 accattctaa ataggtgttt ccattactat gtaccaggct ctgactagat ctgcaagag 59 < 210 > 54 < 211 > 36 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer Murine TRP 2 Forward < 400 > 54 tttctaagct tatgggcctt gtgggatggg ggcttc 36 < 210 > 55 < 211 > 37 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer Murine TRP 2 Reverse < 400 > 55 tttctgatat ctcaggcttc ctccgtgtat ctcttgc 37 < 210 > 56 < 211 > 35 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer GP 100 Forward < 400 > 56 tttctgatat catgggtgtc cagagaagga gcttc 35 < 210 > 57 < 211 > 36 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Primer Gp 100 Reverse < 400 > 57 tttctctcga gtcagacctg ctgtccactg aggagc 36 < 210 > 58 < 211 > 35 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Phosphorylated primer ( TRP 2 epitope example ) < 400 > 58 tagtgtttat gatttttttg tgtggctccg attca 35 < 210 > 59 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( TRP 2 , HLA restriction A 2 , Kb ) < 400 > 59 agtgtttatg atttttttgt gtggctc 27 < 210 > 60 < 211 > 30 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( GP 100 , HLA restriction A 2 ) < 400 > 60 accattactg accaggtgcc tttctccgtg 30 < 210 > 61 < 211 > 30 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( GP 100 ( 210 M ) , HLA restriction A 2 ) < 400 > 61 accattatgg accaggtgcc tttctccgtg 30 < 210 > 62 < 211 > 30 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( GP 100 ( F 7 L ) ) < 400 > 62 accattactg accaggtgcc tttgtccgtg 30 < 210 > 63 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > GP 100 ( F 7 L ) epitope , HLA restriction A 2 < 400 > 63 Ile Thr Asp Gln Val Pro Leu Ser Val 1 5 < 210 > 64 < 211 > 48 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( GP 100 , HLA restriction DR 0401 ) < 400 > 64 tggaacaggc agctgtatcc agagtggaca gaagcccaga gacttgac 48 < 210 > 65 < 211 > 36 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( HEPB S AG , HLA restriction Kd ( CTL ) ) < 400 > 65 ataccgcaga gtctagactc gtggtggact tctctc 36 < 210 > 66 < 211 > 39 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( HepB nucleoprotein , HLA restriction I - Ab ( helper ) ) < 400 > 66 actcctccag cttatagacc accaaatgcc cctatccta 39 < 210 > 67 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( MAGE 3 , HLA restriction A 2 ) < 400 > 67 ttcctgtggg gtccaagggc cctcgtt 27 < 210 > 68 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( MAGE 3 , HLA restriction A 2 ) < 400 > 68 Phe Leu Trp Gly Pro Arg Ala Leu Val 1 5 < 210 > 69 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( Tie 2 ( Z 83 ) , HLA restriction A 2 ) < 400 > 69 ttcctaccag ctactttaac tatgact 27 < 210 > 70 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( Tie 2 ( Z 83 ) , HLA restriction A 2 ) < 400 > 70 Phe Leu Pro Ala Thr Leu Thr Met Thr 1 5 < 210 > 71 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( Tie 2 ( Z 84 ) , HLA restriction A 2 ) < 400 > 71 ttcctaccag ctactttaac tatggtt 27 < 210 > 72 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( Tie 2 ( Z 84 ) , HLA restriction A 2 ) < 400 > 72 Phe Leu Pro Ala Thr Leu Thr Met Val 1 5 < 210 > 73 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( Tie 2 ( Z 9 ) , HLA restriction A 2 ) < 400 > 73 gggatggtgg aaaagccctt caacatt 27 < 210 > 74 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( Tie 2 ( Z 9 ) , HLA restriction A 2 ) < 400 > 74 Gly Met Val Glu Lys Pro Phe Asn Ile 1 5 < 210 > 75 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( Tie 2 ( mZ 9 ) , HLA restriction A 2 ) < 400 > 75 gggatggtgg aaaagccctt caacgtt 27 < 210 > 76 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( Tie 2 ( mZ 9 ) , HLA restriction A 2 ) < 400 > 76 Gly Met Val Glu Lys Pro Phe Asn Val 1 5 < 210 > 77 < 211 > 30 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( FLU HA , HLA restriction I - Ad ( helper ) ) < 400 > 77 tttgaaaggt ttgagatatt ccccaaggaa 30 < 210 > 78 < 211 > 24 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( ovalbumin , HLA restriction Kb ) < 400 > 78 agtataatca actttgaaaa actg 24 < 210 > 79 < 211 > 45 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( Triosephosphate isomerase ( wt ) , HLA restriction DR 0101 ) < 400 > 79 ggggagctca tcggcattct gaacgcggcc aaggtgccgg ccgac 45 < 210 > 80 < 211 > 15 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( Triosephosphate isomerase ( wt ) , HLA restriction DR 0101 ) < 400 > 80 Gly Glu Leu Ile Gly Thr Leu Asn Ala Ala Lys Val Pro Ala Asp 1 5 10 15 < 210 > 81 < 211 > 45 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( Triosephosphate Isomerase ( mI ) , HLA restriction DR 0101 ) < 400 > 81 ggggagctca tcggcactct gaacgcggcc aaggtgccgg ccgac 45 < 210 > 82 < 211 > 15 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( Triosephosphate Isomerase ( mI ) , HLA restriction DR 0101 ) < 400 > 82 Gly Glu Leu Ile Gly Ile Leu Asn Ala Ala Lys Val Pro Ala Asp 1 5 10 15 < 210 > 83 < 211 > 27 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( VEGFR 2 , HLA restriction A 2 ) < 400 > 83 gtgattgcca tgttcttctg gctactt 27 < 210 > 84 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( VEGFR 2 , HLA restriction A 2 ) < 400 > 84 Val Ile Ala Met Phe Phe Trp Leu Leu 1 5 < 210 > 85 < 211 > 28 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( mVEGFR 2 , HLA restriction A 2 ) < 400 > 85 gtgcttgcca tggttcttct ggctactt 28 < 210 > 86 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > CD 8 CTL or CD 4 helpter epitope ( mVEGFR 2 , HLA restriction A 2 ) < 400 > 86 Val Leu Ala Met Phe Phe Trp Leu Leu 1 5 < 210 > 87 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Gp 100 V 5 L epitope < 400 > 87 Thr Ile Thr Asp Gln Leu Pro Phe Ser Val 1 5 10 < 210 > 88 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Predicted HLA - A * 0201 restricted CTL epitope from Tie - 2 ( Z 282 ) < 400 > 88 Ile Leu Ile Asn Ser Leu Pro Leu Val 1 5 < 210 > 89 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Predicted HLA - A * 0201 restricted CTL epitope from Tie - 2 ( Z 283 ) < 400 > 89 Val Leu Ile Lys Glu Glu Asp Ala Val 1 5 < 210 > 90 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Predicted HLA - A * 0201 restricted CTL epitope from Tie - 2 ( Z 284 ) < 400 > 90 Leu Met Asn Gln His Gln Asp Pro Leu 1 5 < 210 > 91 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Predicted HLA - A * 0201 restricted CTL epitope from Tie - 2 ( Z 285 ) < 400 > 91 Val Leu Cys Gly Val Ser Leu Leu Leu 1 5 < 210 > 92 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Predicted HLA - A * 0201 restricted CTL epitope from Tie - 2 ( Z 286 ) < 400 > 92 Leu Val Ser Asp Ala Glu Thr Ser Leu 1 5 < 210 > 93 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Predicted HLA - A * 0201 restricted CTL epitope from Tie - 2 ( Z 287 ) < 400 > 93 Leu Ile Leu Ile Asn Ser Leu Pro Leu 1 5 < 210 > 94 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Predicted HLA - A * 0201 restricted CTL epitope from Tie - 2 ( Z 18 ) < 400 > 94 Gly Ile Leu Gly Phe Val Phe Thr Leu 1 5 < 210 > 95 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > HLA - A 2 restricted peptide derived from VEGFR 2 < 400 > 95 Val Ile Ala Met Phe Phe Trp Leu Leu 1 5 < 210 > 96 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > modified hTERT peptides < 400 > 96 Tyr Leu Phe Phe Tyr Arg Lys Ser Val 1 5 < 210 > 97 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > modified hTERT peptide < 400 > 97 Tyr Leu Gln Val Asn Ser Leu Gln Thr Val 1 5 10 < 210 > 98 < 211 > 1489 < 212 > DNA < 213 > Unknown < 220 > < 223 > Immunobody chimeric heavy chain < 400 > 98 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gtgcagcctc tggattcgct ttcaatacct atgacatgtc ttgggttcgc 180 caggctccgg ggaaggggct ggagtggatc gcatacattg gtagtggtgg tgatagaacc 240 tactatccag acactgtgaa gggccgattc accatttcca gagacaatag caagaacacc 300 ctgtatttgc aattgaacag tctgagggct gaggacacag ccgtgtatta ctgtgcaaga 360 cattatggtc actacgtgga ctatgctgtg gactactggg gtcaaggaac cacggtcacc 420 gtctccagcg cttccaccaa gggcccatcg gtcttccccc tggcaccctc ctccaagagc 480 acctctgggg gcacagcggc cctgggctgc ctggtcaagg actacttccc cgaaccggtg 540 acggtgtcgt ggaactcagg cgccctgacc agcggcgtgc acaccttccc ggctgtccta 600 cagtcctcag gactctactc cctcagcagc gtggtgaccg tgccctccag cagcttgggc 660 acccagacct acatctgcaa cgtgaatcac aagcccagca acaccaaggt ggacaagaaa 720 gttgagccca aatcttgtga caaaactcac acatgcccac cgtgcccagc acctgaactc 780 ctggggggac cgtcagtctt cctcttcccc ccaaaaccca aggacaccct catgatctcc 840 cggacccctg aggtcacatg cgtggtggtg gacgtgagcc acgaagaccc tgaggtcaag 900 ttcaactggt acgtggacgg cgtggaggtg cataatgcca agacaaagcc gcgggaggag 960 cagtacaaca gcacgtaccg tgtggtcagc gtcctcaccg tcctgcacca ggactggctg 1020 aatggcaagg agtacaagtg caaggtctcc aacaaagccc tcccagcccc catcgagaaa 1080 accatctcca aagccaaagg gcagccccga gaaccacagg tgtacaccct gcccccatcc 1140 cgggatgagc tgaccaagaa ccaggtcagc ctgacctgcc tggtcaaagg cttctatccc 1200 agcgacatcg ccgtggagtg ggagagcaat gggcagccgg agaacaacta caagaccacg 1260 cctcccgtgc tggactccga cggctccttc ttcctctaca gcaagctcac cgtggacaag 1320 agcaggtggc agcaggggaa cgtcttctca tgctccgtga tgcatgaggc tctgcacaac 1380 cactacacgc agaagagcct ctccctgtct ccgggtaaat gatctaaagg gcgaattcgc 1440 ccttaagggc gaattttgca gatatccatc acactggcgg ccgctcgag 1489 < 210 > 99 < 211 > 467 < 212 > PRT < 213 > Unknown < 220 > < 223 > Immunobody chimeric heavy chain < 400 > 99 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Met Gly Trp Ser Cys 20 25 30 Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly Val His Ser Gln Val 35 40 45 Gln Leu Val Glu Thr Gly Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 50 55 60 Ala Tyr Ile Gly Ser Gly Gly Asp Arg Thr Tyr Tyr Pro Asp Thr Val 65 70 75 80 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 85 90 95 Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 100 105 110 Ala Arg His Tyr Gly His Tyr Val Asp Tyr Ala Val Asp Tyr Trp Gly 115 120 125 Gln Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 130 135 140 Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala 145 150 155 160 Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 165 170 175 Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala 180 185 190 Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val 195 200 205 Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His 210 215 220 Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys 225 230 235 240 Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 245 250 255 Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 260 265 270 Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 275 280 285 Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 290 295 300 His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 305 310 315 320 Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 325 330 335 Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 340 345 350 Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 355 360 365 Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 370 375 380 Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 385 390 395 400 Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 405 410 415 Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 420 425 430 Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 435 440 445 His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 450 455 460 Pro Gly Lys 465 < 210 > 100 < 211 > 732 < 212 > DNA < 213 > Unknown < 220 > < 223 > Immunbody chimeric kappa chain < 400 > 100 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctccatct cttgcagatc tagtcagagc ctggtacata gtaatggaaa cacctattta 180 gaatggtacc tgcagaaacc aggccagtct ccacagctcc tgatctacaa agtttccaac 240 cgattttctg gggtcccaga cagattcagt ggcagtggat cagggacaga tttcacactc 300 aagatcagca gagtggaggc tgaggatacc ggagtgtatt actgctttca aggttcacat 360 gttccgtgga cgttcggtgg aggcaccaag gtggaaatca agcgtacggt agcggcccca 420 tctgtcttca tcttcccgcc atctgatgag cagttgaaat ctggaactgc ctctgttgtg 480 tgcctgctga ataacttcta tcccagagag gccaaagtac agtggaaggt ggataacgcc 540 ctccaatcgg gtaactccca ggagagtgtc acagagcagg acagcaagga cagcacctac 600 agcctcagca gcaccctgac gctgagcaaa gcagactacg agaaacacaa agtctacgcc 660 tgcgaagtca cccaccaggg cctgagctcg cccgtcacaa agagcttcaa caggggagag 720 tgttgactcg ag 732 < 210 > 101 < 211 > 238 < 212 > PRT < 213 > Unknown < 220 > < 223 > Immunbody chimeric kappa chain < 400 > 101 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 35 40 45 Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 50 55 60 Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 65 70 75 80 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 85 90 95 Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys 100 105 110 Phe Gln Gly Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val 115 120 125 Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 130 135 140 Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 145 150 155 160 Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 165 170 175 Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 180 185 190 Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 195 200 205 Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 210 215 220 Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 225 230 235 < 210 > 102 < 211 > 376 < 212 > DNA < 213 > Unknown < 220 > < 223 > ImmunoBody heavy chain variable region ( H 1 ) < 400 > 102 atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggagt ccactcccag 60 gtgcagctgg tggagactgg gggaggctta atccagcctg gagggtccct gagaatgtcc 120 tgcgcaggct ccggggaagg ggctggagtg gatcgcatac attggtagtg gtggtgatag 180 aacctactat ccagacactg tgaagggccg attcaccatt tccagagaca atagcaagaa 240 caccctgtat ttgcaattga acagtctgag ggctgaggac acagccgtgt attactgtgc 300 aagacattat ggtcactacg tggactatgc tgtggactac tggggtcaag gtaccacggt 360 caccgtctcc agcgct 376 < 210 > 103 < 211 > 125 < 212 > PRT < 213 > Unknown < 220 > < 223 > ImmunoBody heavy chain variable region ( H 1 ) < 400 > 103 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Gln Ala Pro Gly Lys Gly Leu 35 40 45 Glu Trp Ile Ala Tyr Ile Gly Ser Gly Gly Asp Arg Thr Tyr Tyr Pro 50 55 60 Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 65 70 75 80 Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 85 90 95 Tyr Tyr Cys Ala Arg His Tyr Gly His Tyr Val Asp Tyr Ala Val Asp 100 105 110 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 115 120 125 < 210 > 104 < 211 > 382 < 212 > DNA < 213 > Unknown < 220 > < 223 > ImmunoBody heavy chain variable region ( H 2 ) < 400 > 104 atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggagt ccactcccag 60 gtgcagctgg tggagactgg gggaggctta atccagcctg gagggtccct gagaatgtcc 120 tgtgcagcct ctggattcgc tttcaatacc tatgacatgt cttgggttcg ccaggctccg 180 gggaaggggc tggagtggat cgcatacatt ggtagtggtg gccatttcca gagacaatag 240 caagaacacc ctgtatttgc aattgaacag tctgagggct gaggacacag ccgtgtatta 300 ctgtgcaaga cattatggtc actacgtgga ctatgctgtg gactactggg gtcaaggtac 360 cacggtcacc gtctccagcg ct 382 < 210 > 105 < 211 > 126 < 212 > PRT < 213 > Unknown < 220 > < 223 > ImmunoBody heavy chain variable region ( H 2 ) < 400 > 105 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Ala Ala Ser Gly Phe Ala Phe 35 40 45 Asn Thr Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 50 55 60 Glu Trp Ile Ala Tyr Ile Gly Ser Gly Ile Ser Arg Asp Asn Ser Lys 65 70 75 80 Asn Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala 85 90 95 Val Tyr Tyr Cys Ala Arg His Tyr Gly His Tyr Val Asp Tyr Ala Val 100 105 110 Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 115 120 125 < 210 > 106 < 211 > 383 < 212 > DNA < 213 > Unknown < 220 > < 223 > ImmunoBody heavy chain variable region ( H 3 ) < 400 > 106 atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggagt ccactcccag 60 gtgcagctgg tggagactgg gggaggctta atccagcctg gagggtccct gagaatgtcc 120 tgtgcagcct ctggattcgc tttcaatacc tatgacatgt cttgggttcg ccaggctccg 180 gggaaggggc tggagtggat cgcatacatt ggtagtggtg gtgatagaac ctactatcca 240 gacactgtga agggccgatt caccatttcc agagacaata gcaagaacac cctgtatttg 300 caattgaaca gtctgagggc tgaggacaca gccgtgtatt actgtgcccg ggccaaggta 360 ccacggtcac cgtctccagc gct 383 < 210 > 107 < 211 > 127 < 212 > PRT < 213 > Unknown < 220 > < 223 > ImmunoBody heavy chain variable region ( H 3 ) < 400 > 107 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Ala Ala Ser Gly Phe Ala Phe 35 40 45 Asn Thr Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 50 55 60 Glu Trp Ile Ala Tyr Ile Gly Ser Gly Gly Asp Arg Thr Tyr Tyr Pro 65 70 75 80 Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 85 90 95 Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 100 105 110 Tyr Tyr Cys Ala Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 115 120 125 < 210 > 108 < 211 > 335 < 212 > DNA < 213 > Unknown < 220 > < 223 > ImmunoBody heavy chain variable region ( H 1 / H 2 ) < 400 > 108 atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggagt ccactcccag 60 gtgcagctgg tggagactgg gggaggctta atccagcctg gagggtccct gagaatgtcc 120 tgcgcaggct ccggggaagg ggctggagtg gatcgcatac attggtagtg gtggccattt 180 ccagagacaa tagcaagaac accctgtatt tgcaattgaa cagtctgagg gctgaggaca 240 cagccgtgta ttactgtgca agacattatg gtcactacgt ggactatgct gtggactact 300 ggggtcaagg taccacggtc accgtctcca gcgct 335 < 210 > 109 < 211 > 110 < 212 > PRT < 213 > Unknown < 220 > < 223 > ImmunoBody heavy chain variable region ( H 1 / H 2 ) < 400 > 109 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Gln Ala Pro Gly Lys Gly Leu 35 40 45 Glu Trp Ile Ala Tyr Ile Gly Ser Gly Ile Ser Arg Asp Asn Ser Lys 50 55 60 Asn Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala 65 70 75 80 Val Tyr Tyr Cys Ala Arg His Tyr Gly His Tyr Val Asp Tyr Ala Val 85 90 95 Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 100 105 110 < 210 > 110 < 211 > 336 < 212 > DNA < 213 > Unknown < 220 > < 223 > ImmunoBody heavy chain variable region ( H 1 / H 3 ) < 400 > 110 atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggagt ccactcccag 60 gtgcagctgg tggagactgg gggaggctta atccagcctg gagggtccct gagaatgtcc 120 tgcgcaggct ccggggaagg ggctggagtg gatcgcatac attggtagtg gtggtgatag 180 aacctactat ccagacactg tgaagggccg attcaccatt tccagagaca atagcaagaa 240 caccctgtat ttgcaattga acagtctgag ggctgaggac acagccgtgt attactgtgc 300 ccgggccaag gtaccacggt caccgtctcc agcgct 336 < 210 > 111 < 211 > 111 < 212 > PRT < 213 > Unknown < 220 > < 223 > ImmunoBody heavy chain variable region ( H 1 / H 3 ) < 400 > 111 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Gln Ala Pro Gly Lys Gly Leu 35 40 45 Glu Trp Ile Ala Tyr Ile Gly Ser Gly Gly Asp Arg Thr Tyr Tyr Pro 50 55 60 Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 65 70 75 80 Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 85 90 95 Tyr Tyr Cys Ala Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 100 105 110 < 210 > 112 < 211 > 342 < 212 > DNA < 213 > Unknown < 220 > < 223 > ImmunoBody heavy chain variable region ( H 2 / H 3 ) < 400 > 112 atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggagt ccactcccag 60 gtgcagctgg tggagactgg gggaggctta atccagcctg gagggtccct gagaatgtcc 120 tgtgcagcct ctggattcgc tttcaatacc tatgacatgt cttgggttcg ccaggctccg 180 gggaaggggc tggagtggat cgcatacatt ggtagtggtg gccatttcca gagacaatag 240 caagaacacc ctgtatttgc aattgaacag tctgagggct gaggacacag ccgtgtatta 300 ctgtgcccgg gccaaggtac cacggtcacc gtctccagcg ct 342 < 210 > 113 < 211 > 112 < 212 > PRT < 213 > Unknown < 220 > < 223 > ImmunoBody heavy chain variable region ( H 2 / H 3 ) < 400 > 113 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Ala Ala Ser Gly Phe Ala Phe 35 40 45 Asn Thr Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 50 55 60 Glu Trp Ile Ala Tyr Ile Gly Ser Gly Ile Ser Arg Asp Asn Ser Lys 65 70 75 80 Asn Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala 85 90 95 Val Tyr Tyr Cys Ala Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 100 105 110 < 210 > 114 < 211 > 295 < 212 > DNA < 213 > Unknown < 220 > < 223 > ImmunoBody heavy chain variable region ( H 1 / H 2 / H 3 ) < 400 > 114 atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggagt ccactcccag 60 gtgcagctgg tggagactgg gggaggctta atccagcctg gagggtccct gagaatgtcc 120 tgcgcaggct ccggggaagg ggctggagtg gatcgcatac attggtagtg gtggccattt 180 ccagagacaa tagcaagaac accctgtatt tgcaattgaa cagtctgagg gctgaggaca 240 cagccgtgta ttactgtgcc cgggccaagg taccacggtc accgtctcca gcgct 295 < 210 > 115 < 211 > 96 < 212 > PRT < 213 > Unknown < 220 > < 223 > ImmunoBody heavy chain variable region ( H 1 / H 2 / H 3 ) < 400 > 115 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Gln Ala Pro Gly Lys Gly Leu 35 40 45 Glu Trp Ile Ala Tyr Ile Gly Ser Gly Ile Ser Arg Asp Asn Ser Lys 50 55 60 Asn Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala 65 70 75 80 Val Tyr Tyr Cys Ala Gly Gln Gly Thr Thr Val Thr Val Ser Ser Ala 85 90 95 < 210 > 116 < 211 > 340 < 212 > DNA < 213 > Unknown < 220 > < 223 > Immunobody kappa chain variable region ( L 1 ) < 400 > 116 atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggagt ccactccgat 60 gtgttgatga cccaatctcc actctccctg cctgtcactc ctggggagcc agcctcgata 120 tctgcagaaa ccaggccagt ctccacagct cctgatctac aaagtttcca accgattttc 180 tggggtccca gacagattca gtggcagtgg atcagggaca gatttcacac tcaagatcag 240 cagagtggag gctgaggata ccggagtgta ttactgcttt caaggttcac atgttccgtg 300 gacgttcggt ggaggcacca aggtggaaat caagcgtacg 340 < 210 > 117 < 211 > 110 < 212 > PRT < 213 > Unknown < 220 > < 223 > Immunobody kappa chain variable region ( L 1 ) < 400 > 117 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Leu Gln Lys Pro Gly Gln Ser Pro Gln 35 40 45 Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 50 55 60 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 65 70 75 80 Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys Phe Gln Gly Ser His 85 90 95 Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 < 210 > 118 < 211 > 360 < 212 > DNA < 213 > Unknown < 220 > < 223 > Immunobody kappa chain variable region ( L 2 ) < 400 > 118 atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggagt ccactccgat 60 gtgttgatga cccaatctcc actctccctg cctgtcactc ctggggagcc agcctccatc 120 tcttgcagat ctagtcagag cctggtacat agtaatggaa acacctattt agaatggtac 180 ctgcagaaac caggccagtc tccacagctc ctaatattca gtggcagtgg atcagggaca 240 gatttcacac tcaagatcag cagagtggag gctgaggata ccggagtgta ttactgcttt 300 caaggttcac atgttccgtg gacgttcggt ggaggcacca aggtggaaat caagcgtacg 360 360 < 210 > 119 < 211 > 117 < 212 > PRT < 213 > Unknown < 220 > < 223 > Immunobody kappa chain variable region ( L 2 ) < 400 > 119 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 35 40 45 Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 50 55 60 Gly Gln Ser Pro Gln Leu Leu Phe Ser Gly Ser Gly Ser Gly Thr Asp 65 70 75 80 Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr 85 90 95 Tyr Cys Phe Gln Gly Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr 100 105 110 Lys Val Glu Ile Lys 115 < 210 > 120 < 211 > 352 < 212 > DNA < 213 > Unknown < 220 > < 223 > Immunobody kappa chain variable region ( L 3 ) < 400 > 120 atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggagt ccactccgat 60 gtgttgatga cccaatctcc actctccctg cctgtcactc ctggggagcc agcctccatc 120 tcttgcagat ctagtcagag cctggtacat agtaatggaa acacctattt agaatggtac 180 ctgcagaaac caggccagtc tccacagctc ctgatctaca aagtttccaa ccgattttct 240 ggggtcccag acagattcag tggcagtgga tcagggacag atttcacact caagatcagc 300 agagtggagg ctgaggatac cggagttaac caaggtggaa atcaagcgta cg 352 < 210 > 121 < 211 > 115 < 212 > PRT < 213 > Unknown < 220 > < 223 > Immunobody kappa chain variable region ( L 3 ) < 400 > 121 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 35 40 45 Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 50 55 60 Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 65 70 75 80 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 85 90 95 Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Thr Gly Val Thr Lys Val 100 105 110 Glu Ile Lys 115 < 210 > 122 < 211 > 301 < 212 > DNA < 213 > Unknown < 220 > < 223 > Immunobody kappa chain variable region ( L 1 / L 3 ) < 400 > 122 atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggagt ccactccgat 60 gtgttgatga cccaatctcc actctccctg cctgtcactc ctggggagcc agcctcgata 120 tctgcagaaa ccaggccagt ctccacagct cctaatattc agtggcagtg gatcagggac 180 agatttcaca ctcaagatca gcagagtgga ggctgaggat accggagtgt attactgctt 240 tcaaggttca catgttccgt ggacgttcgg tggaggcacc aaggtggaaa tcaagcgtac 300 g 301 < 210 > 123 < 211 > 96 < 212 > PRT < 213 > Unknown < 220 > < 223 > Immunobody kappa chain variable region ( L 1 / L 3 ) < 400 > 123 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Leu Gln Lys Pro Gly Gln Ser Pro Gln 35 40 45 Leu Leu Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 50 55 60 Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys Phe Gln Gly 65 70 75 80 Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 85 90 95 < 210 > 124 < 211 > 313 < 212 > DNA < 213 > Unknown < 220 > < 223 > Immunobody kappa chain variable region ( L 2 / L 3 ) < 400 > 124 atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggagt ccactccgat 60 gtgttgatga cccaatctcc actctccctg cctgtcactc ctggggagcc agcctccatc 120 tcttgcagat ctagtcagag cctggtacat agtaatggaa acacctattt agaatggtac 180 ctgcagaaac caggccagtc tccacagctc ctaatattca gtggcagtgg atcagggaca 240 gatttcacac tcaagatcag cagagtggag gctgaggata ccggagttaa ccaaggtgga 300 aatcaagcgt acg 313 < 210 > 125 < 211 > 101 < 212 > PRT < 213 > Unknown < 220 > < 223 > Immunobody kappa chain variable region ( L 2 / L 3 ) < 400 > 125 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 35 40 45 Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 50 55 60 Gly Gln Ser Pro Gln Leu Leu Phe Ser Gly Ser Gly Ser Gly Thr Asp 65 70 75 80 Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Thr Gly Val Thr 85 90 95 Lys Val Glu Ile Lys 100 < 210 > 126 < 211 > 254 < 212 > DNA < 213 > Unknown < 220 > < 223 > Immunobody kappa chain variable region ( L 1 / L 2 / L 3 ) < 400 > 126 atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggagt ccactccgat 60 gtgttgatga cccaatctcc actctccctg cctgtcactc ctggggagcc agcctcgata 120 tctgcagaaa ccaggccagt ctccacagct cctaatattc agtggcagtg gatcagggac 180 agatttcaca ctcaagatca gcagagtgga ggctgaggat accggagtta accaaggtgg 240 aaatcaagcg tacg 254 < 210 > 127 < 211 > 80 < 212 > PRT < 213 > Unknown < 220 > < 223 > Immunobody kappa chain variable region ( L 1 / L 2 / L 3 ) < 400 > 127 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Leu Gln Lys Pro Gly Gln Ser Pro Gln 35 40 45 Leu Leu Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 50 55 60 Ser Arg Val Glu Ala Glu Asp Thr Gly Val Thr Lys Val Glu Ile Lys 65 70 75 80 < 210 > 128 < 211 > 293 < 212 > DNA < 213 > Unknown < 220 > < 223 > Immunobody kappa chain variable region ( L 1 / L 3 ) < 400 > 128 atgggatgga gctgtatcat cctcttcttg gtagcaacag ctaccggagt ccactccgat 60 gtgttgatga cccaatctcc actctccctg cctgtcactc ctggggagcc agcctcgata 120 tctgcagaaa ccaggccagt ctccacagct cctgatctac aaagtttcca accgattttc 180 tggggtccca gacagattca gtggcagtgg atcagggaca gatttcacac tcaagatcag 240 cagagtggag gctgaggata ccggagttaa ccaaggtgga aatcaagcgt acg 293 < 210 > 129 < 211 > 94 < 212 > PRT < 213 > Unknown < 220 > < 223 > Immunobody kappa chain variable region ( L 1 / L 3 ) < 400 > 129 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Leu Gln Lys Pro Gly Gln Ser Pro Gln 35 40 45 Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 50 55 60 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 65 70 75 80 Val Glu Ala Glu Asp Thr Gly Val Thr Lys Val Glu Ile Lys 85 90 < 210 > 130 < 211 > 720 < 212 > DNA < 213 > Unknown < 220 > < 223 > Immunobody IB 15 heavy chain < 400 > 130 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gcaccattat ggaccaggtg cctttctccg tgtgggttcg gcaggctccg 180 gggaaggggc tggagtggat cgcatacatt ggtagtggtg gtagtgttta tgattttttt 240 gtgtggctcc gattcaccat ttccagagac aatagcaaga acaccctgta tttgcaattg 300 aacagtctga gggctgagga cacagccgtg tattactgtg cgagacatta tggtcactac 360 gtggactatg ctgtggacta ctggggtcaa ggtaccacgg tcaccgtctc cagcgcttcc 420 accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca 480 gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac 540 tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc 600 tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc 660 tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagtttg acccaaatct 720 720 < 210 > 131 < 211 > 236 < 212 > PRT < 213 > Unknown < 220 > < 223 > Immunobody IB 15 heavy chain < 400 > 131 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Thr Ile Met Asp Gln Val Pro 35 40 45 Phe Ser Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 50 55 60 Ala Tyr Ile Gly Ser Gly Gly Ser Val Tyr Asp Phe Phe Val Trp Leu 65 70 75 80 Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 85 90 95 Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 100 105 110 His Tyr Gly His Tyr Val Asp Tyr Ala Val Asp Tyr Trp Gly Gln Gly 115 120 125 Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 130 135 140 Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 145 150 155 160 Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 165 170 175 Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 180 185 190 Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 195 200 205 Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 210 215 220 Ser Asn Thr Lys Val Asp Lys Lys Val Pro Lys Ser 225 230 235 < 210 > 132 < 211 > 363 < 212 > DNA < 213 > Unknown < 220 > < 223 > DCIB 15 heavy variable region without a leader ( heavy chain ) < 400 > 132 aagcttacca tgcaggtgca gctggtggag actgggggag gcttaatcca gcctggaggg 60 tccctgagaa tgtcctgcac cattatggac caggtgcctt tctccgtgtg ggttcggcag 120 gctccgggga aggggctgga gtggatcgca tacattggta gtggtggtag tgtttatgat 180 ttttttgtgt ggctccgatt caccatttcc agagacaata gcaagaacac cctgtatttg 240 caattgaaca gtctgagggc tgaggacaca gccgtgtatt actgtgcgag acattatggt 300 cactacgtgg actatgctgt ggactactgg ggtcaaggta ccacggtcac cgtctccagc 360 gct 363 < 210 > 133 < 211 > 117 < 212 > PRT < 213 > Unknown < 220 > < 223 > DCIB 15 heavy variable region without a leader ( heavy chain ) < 400 > 133 Met Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln Pro Gly 1 5 10 15 Gly Ser Leu Arg Met Ser Cys Thr Ile Met Asp Gln Val Pro Phe Ser 20 25 30 Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala Tyr 35 40 45 Ile Gly Ser Gly Gly Ser Val Tyr Asp Phe Phe Val Trp Leu Arg Phe 50 55 60 Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln Leu Asn 65 70 75 80 Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg His Tyr 85 90 95 Gly His Tyr Val Asp Tyr Ala Val Asp Tyr Trp Gly Gln Gly Thr Thr 100 105 110 Val Thr Val Ser Ser 115 < 210 > 134 < 211 > 345 < 212 > DNA < 213 > Unknown < 220 > < 223 > DCIB 15 kappa variable region without a leader ( light chain ) < 400 > 134 ggatccacca tggatgtgtt gatgacccaa tctccactct ccctgcctgt cactcctggg 60 gagccagcct ccatctcttg cactcctcca gcttatagac caccaaatgc ccctatccta 120 tggtatctgc agaaaccagg ccagtctcca cagctcctga tctacaaagt ttccaaccga 180 ttttctgggg tcccagacag attcagtggc agtggatcag ggacagattt cacactcaag 240 atcagcagag tggaggctga ggataccgga gtgtattact gctttcaagg ttcacatgtt 300 ccgtggacgt tcggtggagg caccaaggtg gaaatcaagc gtacg 345 < 210 > 135 < 211 > 110 < 212 > PRT < 213 > Unknown < 220 > < 223 > DCIB 15 kappa variable region without a leader ( light chain ) < 400 > 135 Met Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro 1 5 10 15 Gly Glu Pro Ala Ser Ile Ser Cys Thr Pro Pro Ala Tyr Arg Pro Pro 20 25 30 Asn Ala Pro Ile Leu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln 35 40 45 Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 50 55 60 Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg 65 70 75 80 Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys Phe Gln Gly Ser His 85 90 95 Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 < 210 > 136 < 211 > 857 < 212 > DNA < 213 > Homo sapiens < 400 > 136 agcgcttcca ccaagggccc atcggtcttc cccctggcgc cctgctccag gagcacctcc 60 gagagcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg 120 tcgtggaact caggcgctct gaccagcggc gtgcacacct tcccggctgt cctacagtcc 180 tcaggactct actccctcag cagcgtggtg accgtgccct ccagcaactt cggcacccag 240 acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gacagttgag 300 cgcaaatgtt gtgtcgagtg cccaccgtgc ccagcaccac ctgtggcagg accgtcagtc 360 ttcctcttcc ccccaaaacc caaggacacc ctcatgatct cccggacccc tgaggtcacg 420 tgcgtggtgg tggacgtgag ccacgaagac cccgaggtcc agttcaactg gtacgtggac 480 ggcgtggagg tgcataatgc caagacaaag ccacgggagg agcagttcaa cagcacgttc 540 cgtgtggtca gcgtcctcac cgtcgtgcac caggactggc tgaacggcaa ggagtacaag 600 tgcaaggtct ccaacaaagg cctcccagcc cccatcgaga aaaccatctc caaaaccaaa 660 gggcagcccc gagaaccaca ggtgtacacc ctgcccccat cccgggagga gatgaccaag 720 aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag 780 tgggagagca atgggcagcc ggagaacaac ctaagggcga attctgcaga tatccagcac 840 agtggcggcc gctcgag 857 < 210 > 137 < 211 > 654 < 212 > PRT < 213 > Homo sapiens < 400 > 137 Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 1 5 10 15 Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 20 25 30 Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 35 40 45 Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 50 55 60 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln 65 70 75 80 Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp 85 90 95 Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala 100 105 110 Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 115 120 125 Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 130 135 140 Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 145 150 155 160 Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 165 170 175 Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val Val His Gln Asp 180 185 190 Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 195 200 205 Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg 210 215 220 Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys 225 230 235 240 Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 245 250 255 Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 260 265 270 Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 275 280 285 Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 290 295 300 Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 305 310 315 320 Leu Ser Leu Ser Pro Gly Lys Ser Ala Ser Thr Lys Gly Pro Ser Val 325 330 335 Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 340 345 350 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 355 360 365 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 370 375 380 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 385 390 395 400 Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys 405 410 415 Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val 420 425 430 Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 435 440 445 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 450 455 460 Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 465 470 475 480 Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 485 490 495 Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val 500 505 510 Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 515 520 525 Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 530 535 540 Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 545 550 555 560 Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 565 570 575 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 580 585 590 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp 595 600 605 Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 610 615 620 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 625 630 635 640 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 645 650 < 210 > 138 < 211 > 1164 < 212 > DNA < 213 > Homo sapiens < 400 > 138 agcgcttcca ccaagggccc atcggtcttc cccctggcgc cctgctccag gagcacctct 60 gggggcacag cggccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg 120 tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc 180 tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacccag 240 acctacacct gcaacgtgaa tcacaagccc agcaacacca aggtggacaa gagagttgag 300 ctcaaaaccc cacttggtga cacaactcac acatgcccac ggtgcccaga gcccaaatct 360 tgtgacacac ctcccccgtg cccacggtgc ccagagccca aatcttgtga cacacctccc 420 ccatgcccac ggtgcccaga gcccaaatct tgtgacacac ctcccccatg cccacggtgc 480 ccagcacctg aactcctggg aggaccgtca gtcttcctct tccccccaaa acccaaggat 540 acccttatga tttcccggac ccctgaggtc acgtgcgtgg tggtggacgt gagccacgaa 600 gaccccgagg tccagttcaa gtggtacgtg gacggcgtgg aggtgcataa tgccaagaca 660 aagccgcggg aggagcagtt caacagcacg ttccgtgtgg tcagcgtcct caccgtcctg 720 caccaggact ggctgaacgg caaggagtac aagtgcaagg tctccaacaa agccctccca 780 gcccccatcg agaaaaccat ctccaaaacc aaaggacagc cccgagaacc acaggtgtac 840 accctgcccc catcccggga ggagatgacc aagaaccagg tcagcctgac ctgcctggtc 900 aaaggcttct accccagcga catcgccgtg gagtgggaga gcagcgggca gccggagaac 960 aactacaaca ccacgcctcc catgctggac tccgacggct ccttcttcct ctacagcaag 1020 ctcaccgtgg acaagagcag gtggcagcag gggaacatct tctcatgctc cgtgatgcat 1080 gaggctctgc acaaccgctt cacgcagaag agcctctccc tgtctccggg taaatgatat 1140 ccatcacact ggcggccgct cgag 1164 < 210 > 139 < 211 > 377 < 212 > PRT < 213 > Homo sapiens < 400 > 139 Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser 1 5 10 15 Arg Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 20 25 30 Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 35 40 45 Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 50 55 60 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 65 70 75 80 Thr Tyr Thr Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 85 90 95 Lys Arg Val Glu Leu Lys Thr Pro Leu Gly Asp Thr Thr His Thr Cys 100 105 110 Pro Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro 115 120 125 Arg Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg 130 135 140 Cys Pro Glu Pro Lys Ser Cys Asp Thr Pro Pro Pro Cys Pro Arg Cys 145 150 155 160 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 165 170 175 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 180 185 190 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Lys Trp 195 200 205 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 210 215 220 Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val His 225 230 235 240 Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 245 250 255 Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Gln 260 265 270 Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met 275 280 285 Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 290 295 300 Ser Asp Ile Ala Val Glu Trp Glu Ser Ser Gly Gln Pro Glu Asn Asn 305 310 315 320 Tyr Asn Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe Phe Leu 325 330 335 Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Ile 340 345 350 Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn Arg Phe Thr Gln 355 360 365 Lys Ser Leu Ser Leu Ser Pro Gly Lys 370 375 < 210 > 140 < 211 > 1440 < 212 > DNA < 213 > Unknown < 220 > < 223 > DCIB 66 heavy chain < 400 > 140 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gcaccattat ggaccaggtg cctttctccg tgtgggttcg gcaggctccg 180 gggaaggggc tggagtggat cgcatacatt ggtagtggtg gtagtgttta tgattttttt 240 gtgtggctcc gattcaccat ttccagagac aatagcaaga acaccctgta tttgcaattg 300 aacagtctga gggctgagga cacagccgtg tattactgtg cgagacatta tggtcactac 360 gtggactatg ctgtggacta ctggggtcaa ggtaccacgg tcaccgtctc cagcgcttcc 420 accaagggcc catcggtctt ccccctggca ccctcctcca agagcacctc tgggggcaca 480 gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac 540 tcaggcgccc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc 600 tactccctca gcagcgtggt gaccgtgccc tccagcagct tgggcaccca gacctacatc 660 tgcaacgtga atcacaagcc cagcaacacc aaggtggaca agaaagttga gcccaaatct 720 tgtgacaaaa ctcacacatg cccaccgtgc ccagcacctc cagtcgcggg gggaccgtca 780 gtcttcctct tccccccaaa acccaaggac accctcatga tctcccggac ccctgaggtc 840 acatgcgtgg tggtggacgt gagccacgaa gaccctgagg tcaagttcaa ctggtacgtg 900 gacggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagta caacagcacg 960 taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaatgg caaggagtac 1020 aagtgcaagg tctccaacaa agccctccca gcccccatcg agaaaaccat ctccaaagcc 1080 aaagggcagc cccgagaacc acaggtgtac accctgcccc catcccggga tgagctgacc 1140 aagaaccagg tcagcctgac ctgcctggtc aaaggcttct atcccagcga catcgccgtg 1200 gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac 1260 tccgacggct ccttcttcct ctacagcaag ctcaccgtgg acaagagcag gtggcagcag 1320 gggaacgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacgcagaag 1380 agcctctccc tgtctccggg taaatgatct aaagggcgaa ttcgccctta agggcgaatt 1440 1440 < 210 > 141 < 211 > 465 < 212 > PRT < 213 > Unknown < 220 > < 223 > DCIB 66 heavy chain < 400 > 141 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Thr Ile Met Asp Gln Val Pro 35 40 45 Phe Ser Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 50 55 60 Ala Tyr Ile Gly Ser Gly Gly Ser Val Tyr Asp Phe Phe Val Trp Leu 65 70 75 80 Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 85 90 95 Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 100 105 110 His Tyr Gly His Tyr Val Asp Tyr Ala Val Asp Tyr Trp Gly Gln Gly 115 120 125 Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 130 135 140 Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 145 150 155 160 Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 165 170 175 Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 180 185 190 Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 195 200 205 Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 210 215 220 Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 225 230 235 240 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Gly Pro 245 250 255 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 260 265 270 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 275 280 285 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 290 295 300 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 305 310 315 320 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 325 330 335 Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 340 345 350 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 355 360 365 Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 370 375 380 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 385 390 395 400 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 405 410 415 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 420 425 430 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 435 440 445 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 450 455 460 Lys 465 < 210 > 142 < 211 > 1440 < 212 > DNA < 213 > Unknown < 220 > < 223 > DCIB 67 heavy chain containing G 1 binding motif < 400 > 142 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gcaccattat ggaccaggtg cctttctccg tgtgggttcg gcaggctccg 180 gggaaggggc tggagtggat cgcatacatt ggtagtggtg gtagtgttta tgattttttt 240 gtgtggctcc gattcaccat ttccagagac aatagcaaga acaccctgta tttgcaattg 300 aacagtctga gggctgagga cacagccgtg tattactgtg cgagacatta tggtcactac 360 gtggactatg ctgtggacta ctggggtcaa ggtaccacgg tcaccgtctc cagcgcttcc 420 accaagggcc catcggtctt ccccctggcg ccctgctcca ggagcacctc cgagagcaca 480 gcggccctgg gctgcctggt caaggactac ttccccgaac cggtgacggt gtcgtggaac 540 tcaggcgctc tgaccagcgg cgtgcacacc ttcccggctg tcctacagtc ctcaggactc 600 tactccctca gcagcgtggt gaccgtgccc tccagcaact tcggcaccca gacctacacc 660 tgcaacgtag atcacaagcc cagcaacacc aaggtggaca agacagttga gcgcaaatgt 720 tgtgtcgagt gcccaccgtg cccagcacca gaactgttag gaggaccgtc agtcttcctc 780 ttccccccaa aacccaagga caccctcatg atctcccgga cccctgaggt cacgtgcgtg 840 gtggtggacg tgagccacga agaccccgag gtccagttca actggtacgt ggacggcgtg 900 gaggtgcata atgccaagac aaagccacgg gaggagcagt tcaacagcac gttccgtgtg 960 gtcagcgtcc tcaccgtcgt gcaccaggac tggctgaacg gcaaggagta caagtgcaag 1020 gtctccaaca aaggcctccc agcccccatc gagaaaacca tctccaaaac caaagggcag 1080 ccccgagaac cacaggtgta caccctgccc ccatcccggg aggagatgac caagaaccag 1140 gtcagcctga cctgcctggt caaaggcttc taccccagcg acatcgccgt ggagtgggag 1200 agcaatgggc agccggagaa caactacaag accacacctc ccatgctgga ctccgacggc 1260 tccttcttcc tctacagcaa gctcaccgtg gacaagagca ggtggcagca ggggaacgtc 1320 ttctcatgct ccgtgatgca tgaggctctg cacaaccact acacgcagaa gagcctctcc 1380 ctgtctccgg gtaaatgata tccactaagg gcgaattctg cagatatcca gcacagtggc 1440 1440 < 210 > 143 < 211 > 462 < 212 > PRT < 213 > Unknown < 220 > < 223 > DCIB 67 heavy chain containing G 1 binding motif < 400 > 143 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Thr Ile Met Asp Gln Val Pro 35 40 45 Phe Ser Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 50 55 60 Ala Tyr Ile Gly Ser Gly Gly Ser Val Tyr Asp Phe Phe Val Trp Leu 65 70 75 80 Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 85 90 95 Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 100 105 110 His Tyr Gly His Tyr Val Asp Tyr Ala Val Asp Tyr Trp Gly Gln Gly 115 120 125 Thr Thr Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 130 135 140 Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 145 150 155 160 Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 165 170 175 Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 180 185 190 Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 195 200 205 Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 210 215 220 Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 225 230 235 240 Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe 245 250 255 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 260 265 270 Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 275 280 285 Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 290 295 300 Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val 305 310 315 320 Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 325 330 335 Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 340 345 350 Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 355 360 365 Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 370 375 380 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 385 390 395 400 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp 405 410 415 Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 420 425 430 Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 435 440 445 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 450 455 460 < 210 > 144 < 211 > 417 < 212 > DNA < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned in frame with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( heavy variable ) < 400 > 144 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gcaccattat ggaccaggtg cctttctccg tgtgggttcg gcaggctccg 180 gggaaggggc tggagtggat cgcatacatt ggtagtggtg gtagtgttta tgattttttt 240 gtgtggctcc gattcaccat ttccagagac aatagcaaga acaccctgta tttgcaattg 300 aacagtctga gggctgagga cacagccgtg tattactgtg cgagacatta tggtcactac 360 gtggactatg ctgtggacta ctggggtcaa ggtaccacgg tcaccgtctc cagcgct 417 < 210 > 145 < 211 > 135 < 212 > PRT < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned in frame with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig < 400 > 145 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Thr Ile Met Asp Gln Val Pro 35 40 45 Phe Ser Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 50 55 60 Ala Tyr Ile Gly Ser Gly Gly Ser Val Tyr Asp Phe Phe Val Trp Leu 65 70 75 80 Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 85 90 95 Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 100 105 110 His Tyr Gly His Tyr Val Asp Tyr Ala Val Asp Tyr Trp Gly Gln Gly 115 120 125 Thr Thr Val Thr Val Ser Ser 130 135 < 210 > 146 < 211 > 309 < 212 > DNA < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned in frame with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( light variable ) < 400 > 146 ctctccctgc ctgtcactcc tggggagcca gcctcgatct cttgcactcc tccagcttat 60 agaccaccaa atgcccctat cctatggtat ctgcagaaac caggccagtc tccacagctc 120 ctgatctaca aagtttccaa ccgattttct ggggtcccag acagattcag tggcagtgga 180 tcagggacag atttcacact caagatcagc agagtggagg ctgaggatac cggagtgtat 240 tactgctttc aaggttcaca tgttccgtgg acgttcggtg gaggcaccaa ggtggaaatc 300 aagcgtacg 309 < 210 > 147 < 211 > 128 < 212 > PRT < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned in frame with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( light variable ) < 400 > 147 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Thr Pro Pro Ala Tyr Arg 35 40 45 Pro Pro Asn Ala Pro Ile Leu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 50 55 60 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 65 70 75 80 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys Phe Gln Gly 100 105 110 Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 115 120 125 < 210 > 148 < 211 > 422 < 212 > DNA < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned in frame with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( heavy varaible ) ( Sequence of DCIB 24 ) < 400 > 148 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gtgcagcctc tggattcgct ttcaatacct atgacatgtc ttgggttcgc 180 aggctccggg gaaggggctg gagtggatcg catacattgg tagtggtggt agtataatca 240 actttgaaaa actgcgattc accatttcca gagacaatag caagaacacc ctgtatttgc 300 aattgaacag tctgagggct gaggacacag ccgtgtatta ctgtgcaaga cattatggtc 360 actacgtgga ctatgctgtg gactactggg gtcaaggaac cacggtcacc gtctccagcg 420 ct 422 < 210 > 149 < 211 > 137 < 212 > PRT < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned in frame with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( heavy varaible ) ( Sequence of DCIB 24 ) < 400 > 149 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Ala Ala Ser Gly Phe Ala Phe 35 40 45 Asn Thr Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 50 55 60 Glu Trp Ile Ala Tyr Ile Gly Ser Gly Gly Ser Ile Ile Asn Phe Glu 65 70 75 80 Lys Leu Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 85 90 95 Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 100 105 110 Ala Arg His Tyr Gly His Tyr Val Asp Tyr Ala Val Asp Tyr Trp Gly 115 120 125 Gln Gly Thr Thr Val Thr Val Ser Ser 130 135 < 210 > 150 < 211 > 398 < 212 > DNA < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned in frame with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( light varaible ) ( Sequence of DCIB 24 ) < 400 > 150 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctcgatct cttgcactcc tccagcttat agaccaccaa atgcccctat cctatggtat 180 tgcagaaacc aggccagtct ccacagctcc tgatctacaa agtttccaac cgattttctg 240 gggtcccaga cagattcagt ggcagtggat cagggacaga tttcacactc aagatcagca 300 gagtggaggc tgaggatacc ggagtgtatt actgctttca aggttcacat gttccgtgga 360 cgttcggtgg aggcaccaag gtggaaatca agcgtacg 398 < 210 > 151 < 211 > 128 < 212 > PRT < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned in frame with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( light varaible ) ( Sequence of DCIB 24 ) < 400 > 151 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Thr Pro Pro Ala Tyr Arg 35 40 45 Pro Pro Asn Ala Pro Ile Leu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 50 55 60 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 65 70 75 80 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys Phe Gln Gly 100 105 110 Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 115 120 125 < 210 > 152 < 211 > 417 < 212 > DNA < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned in frame with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( heavy variable ) ( Sequence of DCIB 25 ) < 400 > 152 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gcaccattat ggaccaggtg cctttctccg tgtgggttcg gcaggctccg 180 gggaaggggc tggagtggat cgcatacatt ggtagtggtg gtagtgttta tgattttttt 240 gtgtggctcc gattcaccat ttccagagac aatagcaaga acaccctgta tttgcaattg 300 aacagtctga gggctgagga cacagccgtg tattactgtg cgagacatta tggtcactac 360 gtggactatg ctgtggacta ctggggtcaa ggtaccacgg tcaccgtctc cagcgct 417 < 210 > 153 < 211 > 420 < 212 > DNA < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned in frame with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( light variable ) ( Sequence of DCIB 25 ) < 400 > 153 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctccatct cttgcagatc tagtcagagc ctggtacata gtaatggaaa cacctattta 180 gaatggtacc tgcagaaacc aggccagtct ccacagctcc tgatctacaa agtttccaac 240 cgattttctg gggtcccaga cagattcagt ggcagtggat cagggacaga tttcacactc 300 aagatcagca gagtggaggc tgaggatacc ggagtgtatt actgcactcc tccagcttat 360 agaccaccaa atgcccctat cctattcggt ggaggcacca aggtggaaat caagcgtacg 420 420 < 210 > 154 < 211 > 135 < 212 > PRT < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned in frame with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( light variable ) ( Sequence of DCIB 25 ) < 400 > 154 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 35 40 45 Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 50 55 60 Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 65 70 75 80 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 85 90 95 Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys 100 105 110 Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Phe Gly Gly 115 120 125 Gly Thr Lys Val Glu Ile Lys 130 135 < 210 > 155 < 211 > 135 < 212 > PRT < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned in frame with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( heavy variable ) ( Sequence of DCIB 25 ) < 400 > 155 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Thr Ile Met Asp Gln Val Pro 35 40 45 Phe Ser Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 50 55 60 Ala Tyr Ile Gly Ser Gly Gly Ser Val Tyr Asp Phe Phe Val Trp Leu 65 70 75 80 Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 85 90 95 Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 100 105 110 His Tyr Gly His Tyr Val Asp Tyr Ala Val Asp Tyr Trp Gly Gln Gly 115 120 125 Thr Thr Val Thr Val Ser Ser 130 135 < 210 > 156 < 211 > 423 < 212 > DNA < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( heavy variable ) ( Sequence of DCIB 31 ) < 400 > 156 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gtgcagcctc tggattcgct ttcaatacct atgacatgtc ttgggttcgc 180 caggctccgg ggaaggggct ggagtggatc gcatacattg gtagtggtgg tgatagaacc 240 tactatccag acactgtgaa gggccgattc accatttcca gagacaatag caagaacacc 300 ctgtatttgc aattgaacag tctgagggct gaggacacag ccgtgtatta ctgtgcccga 360 agtgtttatg atttttttgt gtggctctgg ggccaaggaa ccacggtcac cgtctccagc 420 gct 423 < 210 > 157 < 211 > 137 < 212 > PRT < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( heavy variable ) ( Sequence of DCIB 31 ) < 400 > 157 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Ala Ala Ser Gly Phe Ala Phe 35 40 45 Asn Thr Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 50 55 60 Glu Trp Ile Ala Tyr Ile Gly Ser Gly Gly Asp Arg Thr Tyr Tyr Pro 65 70 75 80 Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 85 90 95 Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 100 105 110 Tyr Tyr Cys Ala Arg Ser Val Tyr Asp Phe Phe Val Trp Leu Trp Gly 115 120 125 Gln Gly Thr Thr Val Thr Val Ser Ser 130 135 < 210 > 158 < 211 > 407 < 212 > DNA < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( light variable ) ( Sequence of DCIB 31 ) < 400 > 158 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctccatct cttgcagatc tagtcagagc ctggtacata gtaatggaaa cacctattta 180 gaatggtacc tgcagaaacc aggccagtct ccacagctcc tgatctacaa agtttccaac 240 cgattttctg gggtcccaga cagattcagt gcagtggatc agggacagat ttcacactca 300 agatcagcag agtggaggct gaggataccg gagtgtatta ctgctttcaa ggttcacatg 360 ttccgtggac gttcggtgga ggcaccaagg tggaaatcaa gcgtacg 407 < 210 > 159 < 211 > 131 < 212 > PRT < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( light variable ) ( Sequence of DCIB 31 ) < 400 > 159 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 35 40 45 Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 50 55 60 Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 65 70 75 80 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 85 90 95 Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys 100 105 110 Phe Gln Gly Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val 115 120 125 Glu Ile Lys 130 < 210 > 160 < 211 > 423 < 212 > DNA < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( heavy variable ) ( Sequence of DCIB 32 ) < 400 > 160 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gtgcagcctc tggattcgct ttcaatacct atgacatgtc ttgggttcgc 180 caggctccgg ggaaggggct ggagtggatc gcatacattg gtagtggtgg tgatagaacc 240 tactatccag acactgtgaa gggccgattc accatttcca gagacaatag caagaacacc 300 ctgtatttgc aattgaacag tctgagggct gaggacacag ccgtgtatta ctgtgcccga 360 agtgtttatg atttttttgt gtggctctgg ggccaaggaa ccacggtcac cgtctccagc 420 gct 423 < 210 > 161 < 211 > 137 < 212 > PRT < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( heavy variable ) ( Sequence of DCIB 32 ) < 400 > 161 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Ala Ala Ser Gly Phe Ala Phe 35 40 45 Asn Thr Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 50 55 60 Glu Trp Ile Ala Tyr Ile Gly Ser Gly Gly Asp Arg Thr Tyr Tyr Pro 65 70 75 80 Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 85 90 95 Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 100 105 110 Tyr Tyr Cys Ala Arg Ser Val Tyr Asp Phe Phe Val Trp Leu Trp Gly 115 120 125 Gln Gly Thr Thr Val Thr Val Ser Ser 130 135 < 210 > 162 < 211 > 420 < 212 > DNA < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( light variable ) ( Sequence of DCIB 32 ) < 400 > 162 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctccatct cttgcagatc tagtcagagc ctggtacata gtaatggaaa cacctattta 180 gaatggtacc tgcagaaacc aggccagtct ccacagctcc tgatctacaa agtttccaac 240 cgattttctg gggtcccaga cagattcagt ggcagtggat cagggacaga tttcacactc 300 aagatcagca gagtggaggc tgaggatacc ggagtgtatt actgcactcc tccagcttat 360 agaccaccaa atgcccctat cctattcggt ggaggcacca aggtggaaat caagcgtacg 420 420 < 210 > 163 < 211 > 432 < 212 > DNA < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( heavy variable ) ( Sequence of DCIB 36 ) < 400 > 163 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gtgcagcctc tggattcgct ttcaatacct atgacatgtc ttgggttcgc 180 caggctccgg ggaaggggct ggagtggatc gcatacattg gtagtggtgg tgatagaacc 240 tactatccag acactgtgaa gggccgattc accatttcca gagacaatag caagaacacc 300 ctgtatttgc aattgaacag tctgagggct gaggacacag ccgtgtatta ctgtgcaaga 360 cattatggtc actacgtgga ctatgctgtg gactactggg gtcaaggaac cacggtcacc 420 gtctccagcg ct 432 < 210 > 164 < 211 > 140 < 212 > PRT < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( heavy variable ) ( Sequence of DCIB 36 ) < 400 > 164 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Ala Ala Ser Gly Phe Ala Phe 35 40 45 Asn Thr Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 50 55 60 Glu Trp Ile Ala Tyr Ile Gly Ser Gly Gly Asp Arg Thr Tyr Tyr Pro 65 70 75 80 Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 85 90 95 Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 100 105 110 Tyr Tyr Cys Ala Arg His Tyr Gly His Tyr Val Asp Tyr Ala Val Asp 115 120 125 Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 130 135 140 < 210 > 165 < 211 > 408 < 212 > DNA < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( light variable ) ( Sequence of DCIB 36 ) < 400 > 165 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctccatct cttgcagatc tagtcagagc ctggtacata gtaatggaaa cacctattta 180 gaatggtacc tgcagaaacc aggccagtct ccacagctcc tgatctacaa agtttccaac 240 cgattttctg gggtcccaga cagattcagt ggcagtggat cagggacaga tttcacactc 300 aagatcagca gagtggaggc tgaggatacc ggagtgtatt actgcagtgt ttatgatttt 360 tttgtgtggc tcttcggtgg aggcaccaag gtggaaatca agcgtacg 408 < 210 > 166 < 211 > 131 < 212 > PRT < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( light variable ) ( Sequence of DCIB 36 ) < 400 > 166 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 35 40 45 Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 50 55 60 Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 65 70 75 80 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 85 90 95 Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys 100 105 110 Ser Val Tyr Asp Phe Phe Val Trp Leu Phe Gly Gly Gly Thr Lys Val 115 120 125 Glu Ile Lys 130 < 210 > 167 < 211 > 438 < 212 > DNA < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( heavy variable ) ( Sequence of DCIB 48 ) < 400 > 167 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gtgcagcctc tggattcgct ttcaatacct atgacatgtc ttgggttcgc 180 caggctccgg ggaaggggct ggagtggatc gcatacattg gtagtggtgg tagtgtttat 240 gatttttttg tgtggctccg attcaccatt tccagagaca atagcaagaa caccctgtat 300 ttgcaattga acagtctgag ggctgaggac acagccgtgt attactgtgc ccgatggaac 360 aggcagctgt atccagagtg gacagaagcc cagagacttg actggggcca aggaaccacg 420 gtcaccgtct ccagcgct 438 < 210 > 168 < 211 > 142 < 212 > PRT < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( heavy variable ) ( Sequence of DCIB 48 ) < 400 > 168 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Ala Ala Ser Gly Phe Ala Phe 35 40 45 Asn Thr Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 50 55 60 Glu Trp Ile Ala Tyr Ile Gly Ser Gly Gly Ser Val Tyr Asp Phe Phe 65 70 75 80 Val Trp Leu Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 85 90 95 Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 100 105 110 Cys Ala Arg Trp Asn Arg Gln Leu Tyr Pro Glu Trp Thr Glu Ala Gln 115 120 125 Arg Leu Asp Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 130 135 140 < 210 > 169 < 211 > 317 < 212 > DNA < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( light variable ) ( Sequence of DCIB 48 ) < 400 > 169 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctccatct cttgcagatc tagtcagagc ctggtacata gtaatggaaa cacctattta 180 gcagtggatc agggacagat ttcacactca agatcagcag agtggaggct gaggataccg 240 gagtgtatta ctgctttcaa ggttcacatg ttccgtggac gttcggtgga ggcaccaagg 300 tggaaatcaa gcgtacg 317 < 210 > 170 < 211 > 435 < 212 > DNA < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( heavy variable ) ( Sequence of DCIB 49 ) < 400 > 170 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gtgcagcctc tggattcgct ttcaatacct atgacatgtc ttgggttcgc 180 caggctccgg ggaaggggct ggagtggatc gcatacattg gtagtggtgg tgatagaacc 240 tactatccag acactgtgaa gggccgattc accatttcca gagacaatag caagaacacc 300 ctgtatttgc aattgaacag tctgagggct gaggacacag ccgtgtatta ctgtgcccga 360 actcctccag cttatagacc accaaatgcc cctatcctat ggggccaagg aaccacggtc 420 accgtctcca gcgct 435 < 210 > 171 < 211 > 141 < 212 > PRT < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( heavy variable ) ( Sequence of DCIB 49 ) < 400 > 171 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Ala Ala Ser Gly Phe Ala Phe 35 40 45 Asn Thr Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 50 55 60 Glu Trp Ile Ala Tyr Ile Gly Ser Gly Gly Asp Arg Thr Tyr Tyr Pro 65 70 75 80 Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 85 90 95 Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 100 105 110 Tyr Tyr Cys Ala Arg Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro 115 120 125 Ile Leu Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 130 135 140 < 210 > 172 < 211 > 408 < 212 > DNA < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( light variable ) ( Sequence of DCIB 49 ) < 400 > 172 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctccatct cttgcagatc tagtcagagc ctggtacata gtaatggaaa cacctattta 180 gaatggtacc tgcagaaacc aggccagtct ccacagctcc tgatctacaa agtttccaac 240 cgattttctg gggtcccaga cagattcagt ggcagtggat cagggacaga tttcacactc 300 aagatcagca gagtggaggc tgaggatacc ggagtgtatt actgctttca aggttcacat 360 gttccgtgga cgttcggtgg aggcaccaag gtggaaatca agcgtacg 408 < 210 > 173 < 211 > 429 < 212 > DNA < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( heavy variable ) ( Sequence of DCIB 52 ) < 400 > 173 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gtgcagcctc tggattcgct ttcaatacct atgacatgtc ttgggttcgc 180 caggctccgg ggaaggggct ggagtggatc gcatacattg gtagtggtgg tagtgtttat 240 gatttttttg tgtggctccg attcaccatt tccagagaca atagcaagaa caccctgtat 300 ttgcaattga acagtctgag ggctgaggac acagccgtgt attactgtgc ccgaactcct 360 ccagcttata gaccaccaaa tgcccctatc ctatggggcc aaggaaccac ggtcaccgtc 420 tccagcgct 429 < 210 > 174 < 211 > 139 < 212 > PRT < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( heavy variable ) ( Sequence of DCIB 52 ) < 400 > 174 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Ala Ala Ser Gly Phe Ala Phe 35 40 45 Asn Thr Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 50 55 60 Glu Trp Ile Ala Tyr Ile Gly Ser Gly Gly Ser Val Tyr Asp Phe Phe 65 70 75 80 Val Trp Leu Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 85 90 95 Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 100 105 110 Cys Ala Arg Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu 115 120 125 Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 130 135 < 210 > 175 < 211 > 407 < 212 > DNA < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( light variable ) ( Sequence of DCIB 52 ) < 400 > 175 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctccatct cttgcagatc tagtcagagc ctggtacata gtaatggaaa cacctatttg 180 aatggtacct gcagaaacca ggccagtctc cacagctcct gatctacaaa gtttccaacc 240 gattttctgg ggtcccagac agattcagtg gcagtggatc agggacagat ttcacactca 300 agatcagcag agtggaggct gaggataccg gagtgtatta ctgctttcaa ggttcacatg 360 ttccgtggac gttcggtgga ggcaccaagg tggaaatcaa gcgtacg 407 < 210 > 176 < 211 > 453 < 212 > DNA < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( heavy variable ) ( Sequence of DCIB 54 ) < 400 > 176 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gcgggacagg cagggcaatg ctgggcacac acaccatgga agtaactgtc 180 taccattggg ttcggcaggc tccggggaag gggctggagt ggatcgcata cattggtagt 240 ggtggtagtg tttatgattt ttttgtgtgg ctccgattca ccatttccag agacaatagc 300 aagaacaccc tgtatttgca attgaacagt ctgagggctg aggacacagc cgtgtattac 360 tgtgcccgat ggaacaggca gctgtatcca gagtggacag aagcccagag acttgactgg 420 ggccaaggta ccacggtcac cgtctccagc gct 453 < 210 > 177 < 211 > 147 < 212 > PRT < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( heavy variable ) ( Sequence of DCIB 54 ) < 400 > 177 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Gly Thr Gly Arg Ala Met Leu 35 40 45 Gly Thr His Thr Met Glu Val Thr Val Tyr His Trp Val Arg Gln Ala 50 55 60 Pro Gly Lys Gly Leu Glu Trp Ile Ala Tyr Ile Gly Ser Gly Gly Ser 65 70 75 80 Val Tyr Asp Phe Phe Val Trp Leu Arg Phe Thr Ile Ser Arg Asp Asn 85 90 95 Ser Lys Asn Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp 100 105 110 Thr Ala Val Tyr Tyr Cys Ala Arg Trp Asn Arg Gln Leu Tyr Pro Glu 115 120 125 Trp Thr Glu Ala Gln Arg Leu Asp Trp Gly Gln Gly Thr Thr Val Thr 130 135 140 Val Ser Ser 145 < 210 > 178 < 211 > 131 < 212 > PRT < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( light variable ) ( Sequence of DCIB 52 ) < 400 > 178 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 35 40 45 Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 50 55 60 Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 65 70 75 80 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 85 90 95 Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys 100 105 110 Phe Gln Gly Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val 115 120 125 Glu Ile Lys 130 < 210 > 179 < 211 > 408 < 212 > DNA < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( light variable ) ( Sequence of DCIB 54 ) < 400 > 179 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctccatct cttgcagatc tagtcagagc ctggtacata gtaatggaaa cacctattta 180 gaatggtacc tgcagaaacc aggccagtct ccacagctcc tgatctacaa agtttccaac 240 cgattttctg gggtcccaga cagattcagt ggcagtggat cagggacaga tttcacactc 300 aagatcagca gagtggaggc tgaggatacc ggagtgtatt actgctttca aggttcacat 360 gttccgtgga cgttcggtgg aggcaccaag gtggaaatca agcgtacg 408 < 210 > 180 < 211 > 131 < 212 > PRT < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( light variable ) ( Sequence of DCIB 54 ) < 400 > 180 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 35 40 45 Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 50 55 60 Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 65 70 75 80 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 85 90 95 Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys 100 105 110 Phe Gln Gly Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val 115 120 125 Glu Ile Lys 130 < 210 > 181 < 211 > 426 < 212 > DNA < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( heavy variable ) ( Sequence of DCIB 18 ) < 400 > 181 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gtgcagcctc tggattcgct ttcaatacct atgacatgtc ttgggttcgc 180 caggctccgg ggaaggggct ggagtggatc gcatacattg gtagtggtgg tagtgtttat 240 gatttttttg tgtggctccg attcaccatt tccagagaca atagcaagaa caccctgtat 300 ttgcaattga acagtctgag ggctgaggac acagccgtgt attactgtgc aagacattat 360 ggtcactacg tggactatgc tgtggactac tggggtcaag gaaccacggt caccgtctcc 420 agcgct 426 < 210 > 182 < 211 > 138 < 212 > PRT < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( heavy variable ) ( Sequence of DCIB 18 ) < 400 > 182 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Ala Ala Ser Gly Phe Ala Phe 35 40 45 Asn Thr Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 50 55 60 Glu Trp Ile Ala Tyr Ile Gly Ser Gly Gly Ser Val Tyr Asp Phe Phe 65 70 75 80 Val Trp Leu Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 85 90 95 Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 100 105 110 Cys Ala Arg His Tyr Gly His Tyr Val Asp Tyr Ala Val Asp Tyr Trp 115 120 125 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 130 135 < 210 > 183 < 211 > 398 < 212 > DNA < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( light variable ) ( Sequence of DCIB 18 ) < 400 > 183 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctcgatct cttgcactcc tccagcttat agaccaccaa atgcccctat cctatggtat 180 tgcagaaacc aggccagtct ccacagctcc tgatctacaa agtttccaac cgattttctg 240 gggtcccaga cagattcagt ggcagtggat cagggacaga tttcacactc aagatcagca 300 gagtggaggc tgaggatacc ggagtgtatt actgctttca aggttcacat gttccgtgga 360 cgttcggtgg aggcaccaag gtggaaatca agcgtacg 398 < 210 > 184 < 211 > 128 < 212 > PRT < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( light variable ) ( Sequence of DCIB 18 ) < 400 > 184 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Thr Pro Pro Ala Tyr Arg 35 40 45 Pro Pro Asn Ala Pro Ile Leu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 50 55 60 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 65 70 75 80 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys Phe Gln Gly 100 105 110 Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 115 120 125 < 210 > 185 < 211 > 135 < 212 > PRT < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( light variable ) ( Sequence of DCIB 32 ) < 400 > 185 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 35 40 45 Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 50 55 60 Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 65 70 75 80 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 85 90 95 Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys 100 105 110 Thr Pro Pro Ala Tyr Arg Pro Pro Asn Ala Pro Ile Leu Phe Gly Gly 115 120 125 Gly Thr Lys Val Glu Ile Lys 130 135 < 210 > 186 < 211 > 131 < 212 > PRT < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( light variable ) ( Sequence of DCIB 48 ) < 400 > 186 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 35 40 45 Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 50 55 60 Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 65 70 75 80 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 85 90 95 Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys 100 105 110 Phe Gln Gly Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val 115 120 125 Glu Ile Lys 130 < 210 > 187 < 211 > 131 < 212 > PRT < 213 > Unknown < 220 > < 223 > Nucleotide and amino acid sequence of the heavy and light variable regions cloned inframe with the human IgG 1 Fc and kappa constant regions within the expression vector pDCOrig ( light variable ) ( Sequence of DCIB 49 ) < 400 > 187 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 35 40 45 Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 50 55 60 Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 65 70 75 80 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 85 90 95 Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys 100 105 110 Phe Gln Gly Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val 115 120 125 Glu Ile Lys 130 < 210 > 188 < 211 > 435 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 21 - Heavy variable < 400 > 188 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gtgcagcctc tggattcgct ttcaatacct atgacatgtc ttgggttcgc 180 caggctccgg ggaaggggct ggagtggatc gcatacattg gtagtggtgg tataccgcag 240 agtctagact cgtggtggac ttctctccga ttcaccattt ccagagacaa tagcaagaac 300 accctgtatt tgcaattgaa cagtctgagg gctgaggaca cagccgtgta ttactgtgca 360 agacattatg gtcactacgt ggactatgct gtggactact ggggtcaagg aaccacggtc 420 accgtctcca gcgct 435 < 210 > 189 < 211 > 141 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 21 - Heavy variable < 400 > 189 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Ala Ala Ser Gly Phe Ala Phe 35 40 45 Asn Thr Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 50 55 60 Glu Trp Ile Ala Tyr Ile Gly Ser Gly Gly Ile Pro Gln Ser Leu Asp 65 70 75 80 Ser Trp Trp Thr Ser Leu Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys 85 90 95 Asn Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala 100 105 110 Val Tyr Tyr Cys Ala Arg His Tyr Gly His Tyr Val Asp Tyr Ala Val 115 120 125 Asp Tyr Trp Gly Gln Gly Thr Thr Val Thr Val Ser Ser 130 135 140 < 210 > 190 < 211 > 390 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 21 - Light variable < 400 > 190 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctccatct cttgctttga aaggtttgag atattcccca aggaatggta cctgcagaaa 180 ccaggccagt ctccacagct cctgatctac aaagtttcca accgattttc tggggtccca 240 gacagattca gtggcagtgg atcagggaca gatttcacac tcaagatcag cagagtggag 300 gctgaggata ccggagtgta ttactgcttt caaggttcac atgttccgtg gacgttcggt 360 ggaggcacca aggtggaaat caagcgtacg 390 < 210 > 191 < 211 > 125 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 21 - Light variable < 400 > 191 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Phe Glu Arg Phe Glu Ile 35 40 45 Phe Pro Lys Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Gln Leu 50 55 60 Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg Phe 65 70 75 80 Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile Ser Arg Val 85 90 95 Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys Phe Gln Gly Ser His Val 100 105 110 Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 115 120 125 < 210 > 192 < 211 > 423 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 26 - Heavy variable < 400 > 192 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gcaccattat ggaccaggtg cctttctccg tgtgggttcg gcaggctccg 180 gggaaggggc tggagtggat cgcatacatt ggtagtggtg gtgatagaac ctactatcca 240 gacactgtga agggccgatt caccatttcc agagacaata gcaagaacac cctgtatttg 300 caattgaaca gtctgagggc tgaggacaca gccgtgtatt actgtgcaag acattatggt 360 cactacgtgg actatgctgt ggactactgg ggtcaaggaa ccacggtcac cgtctccagc 420 gct 423 < 210 > 193 < 211 > 137 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 26 - Heavy variable < 400 > 193 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Thr Ile Met Asp Gln Val Pro 35 40 45 Phe Ser Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 50 55 60 Ala Tyr Ile Gly Ser Gly Gly Asp Arg Thr Tyr Tyr Pro Asp Thr Val 65 70 75 80 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 85 90 95 Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 100 105 110 Ala Arg His Tyr Gly His Tyr Val Asp Tyr Ala Val Asp Tyr Trp Gly 115 120 125 Gln Gly Thr Thr Val Thr Val Ser Ser 130 135 < 210 > 194 < 211 > 399 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 26 - Light variable < 400 > 194 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctcgatct cttgcactcc tccagcttat agaccaccaa atgcccctat cctatggtat 180 ctgcagaaac caggccagtc tccacagctc ctgatctaca aagtttccaa ccgattttct 240 ggggtcccag acagattcag tggcagtgga tcagggacag atttcacact caagatcagc 300 agagtggagg ctgaggatac cggagtgtat tactgctttc aaggttcaca tgttccgtgg 360 acgttcggtg gaggcaccaa ggtggaaatc aagcgtacg 399 < 210 > 195 < 211 > 128 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 26 - Light variable < 400 > 195 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Thr Pro Pro Ala Tyr Arg 35 40 45 Pro Pro Asn Ala Pro Ile Leu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 50 55 60 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 65 70 75 80 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys Phe Gln Gly 100 105 110 Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 115 120 125 < 210 > 196 < 211 > 420 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 26 - Heavy Variable < 400 > 196 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gcttcctacc agctacttta actatggttt gggttcggca ggctccgggg 180 aaggggctgg agtggatcgc atacattggt agtggtggtg atagaaccta ctatccagac 240 actgtgaagg gccgattcac catttccaga gacaatagca agaacaccct gtatttgcaa 300 ttgaacagtc tgagggctga ggacacagcc gtgtattact gtgcaagaca ttatggtcac 360 tacgtggact atgctgtgga ctactggggt caaggaacca cggtcaccgt ctccagcgct 420 420 < 210 > 197 < 211 > 136 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 26 - Heavy Variable < 400 > 197 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Phe Leu Pro Ala Thr Leu Thr 35 40 45 Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala 50 55 60 Tyr Ile Gly Ser Gly Gly Asp Arg Thr Tyr Tyr Pro Asp Thr Val Lys 65 70 75 80 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 85 90 95 Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 100 105 110 Arg His Tyr Gly His Tyr Val Asp Tyr Ala Val Asp Tyr Trp Gly Gln 115 120 125 Gly Thr Thr Val Thr Val Ser Ser 130 135 < 210 > 198 < 211 > 399 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 26 - Light Variable < 400 > 198 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctcgatct cttgcactcc tccagcttat agaccaccaa atgcccctat cctatggtat 180 ctgcagaaac caggccagtc tccacagctc ctgatctaca aagtttccaa ccgattttct 240 ggggtcccag acagattcag tggcagtgga tcagggacag atttcacact caagatcagc 300 agagtggagg ctgaggatac cggagtgtat tactgctttc aaggttcaca tgttccgtgg 360 acgttcggtg gaggcaccaa ggtggaaatc aagcgtacg 399 < 210 > 199 < 211 > 128 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 26 - Light Variable < 400 > 199 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Thr Pro Pro Ala Tyr Arg 35 40 45 Pro Pro Asn Ala Pro Ile Leu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 50 55 60 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 65 70 75 80 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys Phe Gln Gly 100 105 110 Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 115 120 125 < 210 > 200 < 211 > 423 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 37 - heavy variable < 400 > 200 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gcaccattac tgaccaggtg cctttgtccg tgtgggttcg gcaggctccg 180 gggaaggggc tggagtggat cgcatacatt ggtagtggtg gtgatagaac ctactatcca 240 gacactgtga agggccgatt caccatttcc agagacaata gcaagaacac cctgtatttg 300 caattgaaca gtctgagggc tgaggacaca gccgtgtatt actgtgcaag acattatggt 360 cactacgtgg actatgctgt ggactactgg ggtcaaggaa ccacggtcac cgtctccagc 420 gct 423 < 210 > 201 < 211 > 137 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 37 - heavy variable < 400 > 201 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Thr Ile Thr Asp Gln Val Pro 35 40 45 Leu Ser Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 50 55 60 Ala Tyr Ile Gly Ser Gly Gly Asp Arg Thr Tyr Tyr Pro Asp Thr Val 65 70 75 80 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 85 90 95 Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 100 105 110 Ala Arg His Tyr Gly His Tyr Val Asp Tyr Ala Val Asp Tyr Trp Gly 115 120 125 Gln Gly Thr Thr Val Thr Val Ser Ser 130 135 < 210 > 202 < 211 > 399 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 37 - light variable < 400 > 202 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctcgatct cttgcactcc tccagcttat agaccaccaa atgcccctat cctatggtat 180 ctgcagaaac caggccagtc tccacagctc ctgatctaca aagtttccaa ccgattttct 240 ggggtcccag acagattcag tggcagtgga tcagggacag atttcacact caagatcagc 300 agagtggagg ctgaggatac cggagtgtat tactgctttc aaggttcaca tgttccgtgg 360 acgttcggtg gaggcaccaa ggtggaaatc aagcgtacg 399 < 210 > 203 < 211 > 128 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 37 - light variable < 400 > 203 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Thr Pro Pro Ala Tyr Arg 35 40 45 Pro Pro Asn Ala Pro Ile Leu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 50 55 60 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 65 70 75 80 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys Phe Gln Gly 100 105 110 Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 115 120 125 < 210 > 204 < 211 > 423 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 40 - heavy variable < 400 > 204 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gcaccattac tgaccaggtg cctatctccg tgtgggttcg gcaggctccg 180 gggaaggggc tggagtggat cgcatacatt ggtagtggtg gtgatagaac ctactatcca 240 gacactgtga agggccgatt caccatttcc agagacaata gcaagaacac cctgtatttg 300 caattgaaca gtctgagggc tgaggacaca gccgtgtatt actgtgcaag acattatggt 360 cactacgtgg actatgctgt ggactactgg ggtcaaggaa ccacggtcac cgtctccagc 420 gct 423 < 210 > 205 < 211 > 137 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 40 - heavy variable < 400 > 205 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Thr Ile Thr Asp Gln Val Pro 35 40 45 Ile Ser Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 50 55 60 Ala Tyr Ile Gly Ser Gly Gly Asp Arg Thr Tyr Tyr Pro Asp Thr Val 65 70 75 80 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 85 90 95 Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 100 105 110 Ala Arg His Tyr Gly His Tyr Val Asp Tyr Ala Val Asp Tyr Trp Gly 115 120 125 Gln Gly Thr Thr Val Thr Val Ser Ser 130 135 < 210 > 206 < 211 > 399 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 40 - light variable < 400 > 206 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctcgatct cttgcactcc tccagcttat agaccaccaa atgcccctat cctatggtat 180 ctgcagaaac caggccagtc tccacagctc ctgatctaca aagtttccaa ccgattttct 240 ggggtcccag acagattcag tggcagtgga tcagggacag atttcacact caagatcagc 300 agagtggagg ctgaggatac cggagtgtat tactgctttc aaggttcaca tgttccgtgg 360 acgttcggtg gaggcaccaa ggtggaaatc aagcgtacg 399 < 210 > 207 < 211 > 128 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 40 - light variable < 400 > 207 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Thr Pro Pro Ala Tyr Arg 35 40 45 Pro Pro Asn Ala Pro Ile Leu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 50 55 60 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 65 70 75 80 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys Phe Gln Gly 100 105 110 Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 115 120 125 < 210 > 208 < 211 > 423 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 41 - heavy variable < 400 > 208 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gcaccattac tgaccaggtg cctttctccg tgtgggttcg gcaggctccg 180 gggaaggggc tggagtggat cgcatacatt ggtagtggtg gtgatagaac ctactatcca 240 gacactgtga agggccgatt caccatttcc agagacaata gcaagaacac cctgtatttg 300 caattgaaca gtctgagggc tgaggacaca gccgtgtatt actgtgcaag acattatggt 360 cactacgtgg actatgctgt ggactactgg ggtcaaggaa ccacggtcac cgtctccagc 420 gct 423 < 210 > 209 < 211 > 399 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 41 - light variable < 400 > 209 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctcgatct cttgcactcc tccagcttat agaccaccaa atgcccctat cctatggtat 180 ctgcagaaac caggccagtc tccacagctc ctgatctaca aagtttccaa ccgattttct 240 ggggtcccag acagattcag tggcagtgga tcagggacag atttcacact caagatcagc 300 agagtggagg ctgaggatac cggagtgtat tactgctttc aaggttcaca tgttccgtgg 360 acgttcggtg gaggcaccaa ggtggaaatc aagcgtacg 399 < 210 > 210 < 211 > 128 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 41 - light variable < 400 > 210 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Thr Pro Pro Ala Tyr Arg 35 40 45 Pro Pro Asn Ala Pro Ile Leu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 50 55 60 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 65 70 75 80 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys Phe Gln Gly 100 105 110 Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 115 120 125 < 210 > 211 < 211 > 423 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 42 - heavy variable < 400 > 211 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gcaccattac tgaccaggtg ccttactccg tgtgggttcg gcaggctccg 180 gggaaggggc tggagtggat cgcatacatt ggtagtggtg gtgatagaac ctactatcca 240 gacactgtga agggccgatt caccatttcc agagacaata gcaagaacac cctgtatttg 300 caattgaaca gtctgagggc tgaggacaca gccgtgtatt actgtgcaag acattatggt 360 cactacgtgg actatgctgt ggactactgg ggtcaaggaa ccacggtcac cgtctccagc 420 gct 423 < 210 > 212 < 211 > 137 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 42 - heavy variable < 400 > 212 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Thr Ile Thr Asp Gln Val Pro 35 40 45 Tyr Ser Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 50 55 60 Ala Tyr Ile Gly Ser Gly Gly Asp Arg Thr Tyr Tyr Pro Asp Thr Val 65 70 75 80 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 85 90 95 Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 100 105 110 Ala Arg His Tyr Gly His Tyr Val Asp Tyr Ala Val Asp Tyr Trp Gly 115 120 125 Gln Gly Thr Thr Val Thr Val Ser Ser 130 135 < 210 > 213 < 211 > 399 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 42 - light variable < 400 > 213 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctcgatct cttgcactcc tccagcttat agaccaccaa atgcccctat cctatggtat 180 ctgcagaaac caggccagtc tccacagctc ctgatctaca aagtttccaa ccgattttct 240 ggggtcccag acagattcag tggcagtgga tcagggacag atttcacact caagatcagc 300 agagtggagg ctgaggatac cggagtgtat tactgctttc aaggttcaca tgttccgtgg 360 acgttcggtg gaggcaccaa ggtggaaatc aagcgtacg 399 < 210 > 214 < 211 > 128 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 42 - light variable < 400 > 214 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Thr Pro Pro Ala Tyr Arg 35 40 45 Pro Pro Asn Ala Pro Ile Leu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 50 55 60 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 65 70 75 80 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys Phe Gln Gly 100 105 110 Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 115 120 125 < 210 > 215 < 211 > 423 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 43 - heavy variable < 400 > 215 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gcaccattac tgaccagctg cctttctccg tgtgggttcg gcaggctccg 180 gggaaggggc tggagtggat cgcatacatt ggtagtggtg gtgatagaac ctactatcca 240 gacactgtga agggccgatt caccatttcc agagacaata gcaagaacac cctgtatttg 300 caattgaaca gtctgagggc tgaggacaca gccgtgtatt actgtgcaag acattatggt 360 cactacgtgg actatgctgt ggactactgg ggtcaaggaa ccacggtcac cgtctccagc 420 gct 423 < 210 > 216 < 211 > 136 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 43 - heavy variable < 400 > 216 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Thr Ile Thr Asp Gln Leu Pro 35 40 45 Phe Ser Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 50 55 60 Ala Tyr Ile Gly Ser Gly Gly Asp Arg Thr Tyr Tyr Pro Asp Thr Val 65 70 75 80 Lys Gly Arg Phe Thr Ile Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 85 90 95 Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 100 105 110 Arg His Tyr Gly His Tyr Val Asp Tyr Ala Val Asp Tyr Trp Gly Gln 115 120 125 Gly Thr Thr Val Thr Val Ser Ser 130 135 < 210 > 217 < 211 > 128 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 43 - light variable < 400 > 217 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Thr Pro Pro Ala Tyr Arg 35 40 45 Pro Pro Asn Ala Pro Ile Leu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 50 55 60 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 65 70 75 80 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys Phe Gln Gly 100 105 110 Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 115 120 125 < 210 > 218 < 211 > 137 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 41 - heavy variable < 400 > 218 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Thr Ile Thr Asp Gln Val Pro 35 40 45 Phe Ser Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 50 55 60 Ala Tyr Ile Gly Ser Gly Gly Asp Arg Thr Tyr Tyr Pro Asp Thr Val 65 70 75 80 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 85 90 95 Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 100 105 110 Ala Arg His Tyr Gly His Tyr Val Asp Tyr Ala Val Asp Tyr Trp Gly 115 120 125 Gln Gly Thr Thr Val Thr Val Ser Ser 130 135 < 210 > 219 < 211 > 399 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 43 - light variable < 400 > 219 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctcgatct cttgcactcc tccagcttat agaccaccaa atgcccctat cctatggtat 180 ctgcagaaac caggccagtc tccacagctc ctgatctaca aagtttccaa ccgattttct 240 ggggtcccag acagattcag tggcagtgga tcagggacag atttcacact caagatcagc 300 agagtggagg ctgaggatac cggagtgtat tactgctttc aaggttcaca tgttccgtgg 360 acgttcggtg gaggcaccaa ggtggaaatc aagcgtacg 399 < 210 > 220 < 211 > 417 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 35 - heavy variable < 400 > 220 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gcaccattat ggaccaggtg cctttctccg tgtgggttcg gcaggctccg 180 gggaaggggc tggagtggat cgcatacatt ggtagtggtg gtagtgttta tgattttttt 240 gtgtggctcc gattcaccat ttccagagac aatagcaaga acaccctgta tttgcaattg 300 aacagtctga gggctgagga cacagccgtg tattactgtg cgagacatta tggtcactac 360 gtggactatg ctgtggacta ctggggtcaa ggtaccacgg tcaccgtctc cagcgct 417 < 210 > 221 < 211 > 135 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 35 - heavy variable < 400 > 221 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Thr Ile Met Asp Gln Val Pro 35 40 45 Phe Ser Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 50 55 60 Ala Tyr Ile Gly Ser Gly Gly Ser Val Tyr Asp Phe Phe Val Trp Leu 65 70 75 80 Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 85 90 95 Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 100 105 110 His Tyr Gly His Tyr Val Asp Tyr Ala Val Asp Tyr Trp Gly Gln Gly 115 120 125 Thr Thr Val Thr Val Ser Ser 130 135 < 210 > 222 < 211 > 408 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 35 - light variable < 400 > 222 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctcgatct cttgctggaa caggcagctg tatccagagt ggacagaagc ccagagactt 180 gactggtatc tgcagaaacc aggccagtct ccacagctcc tgatctacaa agtttccaac 240 cgattttctg gggtcccaga cagattcagt ggcagtggat cagggacaga tttcacactc 300 aagatcagca gagtggaggc tgaggatacc ggagtgtatt actgctttca aggttcacat 360 gttccgtgga cgttcggtgg aggcaccaag gtggaaatca agcgtacg 408 < 210 > 223 < 211 > 131 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 35 - light variable < 400 > 223 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Trp Asn Arg Gln Leu Tyr 35 40 45 Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Trp Tyr Leu Gln Lys Pro 50 55 60 Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 65 70 75 80 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 85 90 95 Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys 100 105 110 Phe Gln Gly Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val 115 120 125 Glu Ile Lys 130 < 210 > 224 < 211 > 417 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 50 - heavy variable < 400 > 224 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gcaccattat ggaccaggtg cctttctccg tgtgggttcg gcaggctccg 180 gggaaggggc tggagtggat cgcatacatt ggtagtggtg gtagtgttta tgattttttt 240 gtgtggctcc gattcaccat ttccagagac aatagcaaga acaccctgta tttgcaattg 300 aacagtctga gggctgagga cacagccgtg tattactgtg cgagacatta tggtcactac 360 gtggactatg ctgtggacta ctggggtcaa ggtaccacgg tcaccgtctc cagcgct 417 < 210 > 225 < 211 > 135 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 50 - heavy variable < 400 > 225 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Thr Ile Met Asp Gln Val Pro 35 40 45 Phe Ser Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 50 55 60 Ala Tyr Ile Gly Ser Gly Gly Ser Val Tyr Asp Phe Phe Val Trp Leu 65 70 75 80 Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 85 90 95 Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 100 105 110 His Tyr Gly His Tyr Val Asp Tyr Ala Val Asp Tyr Trp Gly Gln Gly 115 120 125 Thr Thr Val Thr Val Ser Ser 130 135 < 210 > 226 < 211 > 431 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 50 - light variable < 400 > 226 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctccatct cttgcagatc tagtcagagc ctggtacata gtaatggaaa cacctattta 180 gaatggtacc tgcagaaacc aggccagtct ccacagctcc tgatctacaa agtttccaac 240 cgattttctg gggtcccaga cagattcagt ggcagtggat cagggacaga tttcacactc 300 aagatcagca gagtggaggc tgaggatacc ggagtgtatt actgctggaa caggcagctg 360 tatccagagt ggacagaagc ccagagactt gacttcggtg gaggcaccaa ggtggaaatc 420 aagcgtacgm g 431 < 210 > 227 < 211 > 138 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 50 - light variable < 400 > 227 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 35 40 45 Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 50 55 60 Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 65 70 75 80 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 85 90 95 Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys 100 105 110 Trp Asn Arg Gln Leu Tyr Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp 115 120 125 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 130 135 < 210 > 228 < 211 > 420 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 71 - Heavy variable < 400 > 228 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gcatcttgat caattcccta cctcttgtat gggttcggca ggctccgggg 180 aaggggctgg agtggatcgc atacattggt agtggtggtg atagaaccta ctatccagac 240 actgtgaagg gccgattcac catttccaga gacaatagca agaacaccct gtatttgcaa 300 ttgaacagtc tgagggctga ggacacagcc gtgtattact gtgcaagaca ttatggtcac 360 tacgtggact atgctgtgga ctactggggt caaggaacca cggtcaccgt ctccagcgct 420 420 < 210 > 229 < 211 > 136 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 71 - Heavy variable < 400 > 229 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Ile Leu Ile Asn Ser Leu Pro 35 40 45 Leu Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Ala 50 55 60 Tyr Ile Gly Ser Gly Gly Asp Arg Thr Tyr Tyr Pro Asp Thr Val Lys 65 70 75 80 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 85 90 95 Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 100 105 110 Arg His Tyr Gly His Tyr Val Asp Tyr Ala Val Asp Tyr Trp Gly Gln 115 120 125 Gly Thr Thr Val Thr Val Ser Ser 130 135 < 210 > 230 < 211 > 399 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 71 - Light variable < 400 > 230 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctcgatct cttgcactcc tccagcttat agaccaccaa atgcccctat cctatggtat 180 ctgcagaaac caggccagtc tccacagctc ctgatctaca aagtttccaa ccgattttct 240 ggggtcccag acagattcag tggcagtgga tcagggacag atttcacact caagatcagc 300 agagtggagg ctgaggatac cggagtgtat tactgctttc aaggttcaca tgttccgtgg 360 acgttcggtg gaggcaccaa ggtggaaatc aagcgtacg 399 < 210 > 231 < 211 > 128 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 71 - Light variable < 400 > 231 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Thr Pro Pro Ala Tyr Arg 35 40 45 Pro Pro Asn Ala Pro Ile Leu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 50 55 60 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 65 70 75 80 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys Phe Gln Gly 100 105 110 Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 115 120 125 < 210 > 232 < 211 > 426 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 72 - heavy variable < 400 > 232 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gtgcagcctc tggattcgct ttcaatacct atgacatgtc ttgggttcgc 180 caggctccgg ggaaggggct ggagtggatc gcatacattg gtagtggtgg tatcttgatc 240 aattccctac ctcttgtacg attcaccatt tccagagaca atagcaagaa caccctgtat 300 ttgcaattga acagtctgag ggctgaggac acagccgtgt attactgtgc aagacattat 360 ggtcactacg tggactatgc tgtggactac tggggtcaag gaaccacggt caccgtctcc 420 agcgct 426 < 210 > 233 < 211 > 138 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 72 - heavy variable < 400 > 233 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Ala Ala Ser Gly Phe Ala Phe 35 40 45 Asn Thr Tyr Asp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 50 55 60 Glu Trp Ile Ala Tyr Ile Gly Ser Gly Gly Ile Leu Ile Asn Ser Leu 65 70 75 80 Pro Leu Val Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu 85 90 95 Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 100 105 110 Cys Ala Arg His Tyr Gly His Tyr Val Asp Tyr Ala Val Asp Tyr Trp 115 120 125 Gly Gln Gly Thr Thr Val Thr Val Ser Ser 130 135 < 210 > 234 < 211 > 399 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 72 - light variable < 400 > 234 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctcgatct cttgcactcc tccagcttat agaccaccaa atgcccctat cctatggtat 180 ctgcagaaac caggccagtc tccacagctc ctgatctaca aagtttccaa ccgattttct 240 ggggtcccag acagattcag tggcagtgga tcagggacag atttcacact caagatcagc 300 agagtggagg ctgaggatac cggagtgtat tactgctttc aaggttcaca tgttccgtgg 360 acgttcggtg gaggcaccaa ggtggaaatc aagcgtacg 399 < 210 > 235 < 211 > 128 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 72 - light variable < 400 > 235 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Thr Pro Pro Ala Tyr Arg 35 40 45 Pro Pro Asn Ala Pro Ile Leu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 50 55 60 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 65 70 75 80 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys Phe Gln Gly 100 105 110 Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 115 120 125 < 210 > 236 < 211 > 1413 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 53 - heavy variable < 400 > 236 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gcaccattat ggaccaggtg cctttctccg tgtgggttcg gcaggctccg 180 gggaaggggc tggagtggat cgcatacatt ggtagtggtg gtagtgttta tgattttttt 240 gtgtggctcc gattcaccat ttccagagac aatagcaaga acaccctgta tttgcaattg 300 aacagtctga gggctgagga cacagccgtg tattactgtg cgagacatta tggtcactac 360 gtggactatg ctgtggacta ctggggtcaa ggtaccacgg tcaccgtctc cagcgctaaa 420 acaacagccc catcggtcta tccactggcc cctgtgtgtg gagatacaac tggctcctcg 480 gtgactctag gatgcctggt caagggttat ttccctgagc cagtgacctt gacctggaac 540 tctggttccc tgtccagtgg tgtgcacacc ttcccagctg tcctgcagtc tgacctctac 600 accctcagca gctcagtgac tgtaacttcg agcacctggc ccagccagtc catcacctgc 660 aatgtggccc acccggcaag cagcaccaag gtggacaaga aaattgagcc cagagggccc 720 acaatcaagc cctgtcctcc atgcaaatgc ccagcaccta acctcttggg tggaccatcc 780 gtcttcatct tccctccaaa gatcaaggat gtactcatga tctccctgag ccccatagtc 840 acatgtgtgg tggtggatgt gagcgaggat gacccagatg tccagatcag ctggtttgtg 900 aacaacgtgg aagtacacac agctcagaca caaacccata gagaggatta caacagtact 960 ctccgggtgg tcagtgccct ccccatccag caccaggact ggatgagtgg caaggagttc 1020 aaatgcaagg tcaacaacaa agacctccca gcgcccatcg agagaaccat ctcaaaaccc 1080 aaagggtcag taagagctcc acaggtatat gtcttgcctc caccagaaga agagatgact 1140 aagaaacagg tcactctgac ctgcatggtc acagacttca tgcctgaaga catttacgtg 1200 gagtggacca acaacgggaa aacagagcta aactacaaga acactgaacc agtcctggac 1260 tctgatggtt cttacttcat gtacagcaag ctgagagtgg aaaagaagaa ctgggtggaa 1320 agaaatagct actcctgttc agtggtccac gagggtctgc acaatcacca cacgactaag 1380 agcttctccc ggactccggg taaatgatct aga 1413 < 210 > 237 < 211 > 465 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 53 - heavy variable < 400 > 237 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Thr Ile Met Asp Gln Val Pro 35 40 45 Phe Ser Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 50 55 60 Ala Tyr Ile Gly Ser Gly Gly Ser Val Tyr Asp Phe Phe Val Trp Leu 65 70 75 80 Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 85 90 95 Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala Arg 100 105 110 His Tyr Gly His Tyr Val Asp Tyr Ala Val Asp Tyr Trp Gly Gln Gly 115 120 125 Thr Thr Val Thr Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr 130 135 140 Pro Leu Ala Pro Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu 145 150 155 160 Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp 165 170 175 Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu 180 185 190 Gln Ser Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser 195 200 205 Thr Trp Pro Ser Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser 210 215 220 Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys 225 230 235 240 Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro 245 250 255 Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser 260 265 270 Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp 275 280 285 Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr 290 295 300 Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val 305 310 315 320 Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu 325 330 335 Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg 340 345 350 Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val 355 360 365 Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr 370 375 380 Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr 385 390 395 400 Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu 405 410 415 Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys 420 425 430 Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu 435 440 445 Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly 450 455 460 Lys 465 < 210 > 238 < 211 > 729 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 53 - light variable < 400 > 238 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctcgatct cttgcactcc tccagcttat agaccaccaa atgcccctat cctatggtat 180 ctgcagaaac caggccagtc tccacagctc ctgatctaca aagtttccaa ccgattttct 240 ggggtcccag acagattcag tggcagtgga tcagggacag atttcacact caagatcagc 300 agagtggagg ctgaggatac cggagtgtat tactgctttc aaggttcaca tgttccgtgg 360 acgttcggtg gaggcaccaa ggtggaaatc aagcgtgcag atgctgcacc aactgtatcg 420 atcttcccac catccagtga gcagttaaca tctggaggtg cctcagtcgt gtgcttcttg 480 aacaacttct accccaaaga catcaatgtc aagtggaaga ttgatggcag tgaacgacaa 540 aatggcgtcc tgaacagttg gactgatcag gacagcaaag acagcaccta cagcatgagc 600 agcaccctca cgttgaccaa ggacgagtat gaacgacata acagctatac ctgtgaggcc 660 actcacaaga catctacttc acccattgtc aagagcttca acaggaatga gtgttagctc 720 gagtctaga 729 < 210 > 239 < 211 > 235 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 53 - light variable < 400 > 239 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Thr Pro Pro Ala Tyr Arg 35 40 45 Pro Pro Asn Ala Pro Ile Leu Trp Tyr Leu Gln Lys Pro Gly Gln Ser 50 55 60 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 65 70 75 80 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 85 90 95 Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys Phe Gln Gly 100 105 110 Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 115 120 125 Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 130 135 140 Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 145 150 155 160 Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 165 170 175 Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 180 185 190 Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 195 200 205 Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 210 215 220 Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 225 230 235 < 210 > 240 < 211 > 1449 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 64 - Heavy variable < 400 > 240 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 actcccaggt gcagctggtg gagactgggc ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gcgggacagg cagggcaatg ctgggcacac acaccatgga agtgactgtc 180 taccattggg ttcggcaggc tccggggaag gggctggagt ggatcgcata cattggtagt 240 ggtggtagtg tttatgattt ttttgtgtgg ctccgattca ccatttccag agacaatagc 300 aagaacaccc tgtatttgca attgaacagt ctgagggctg aggacacagc cgtgtattac 360 tgtgcccgat ggaacaggca gctgtatcca gagtggacag aagcccagag acttgactgg 420 ggccaaggaa ccacggtcac cgtctccagc gctaaaacaa cagccccatc ggtctatcca 480 ctggcccctg tgtgtggaga tacaactggc tcctcggtga ctctaggatg cctggtcaag 540 ggttatttcc ctgagccagt gaccttgacc tggaactctg gttccctgtc cagtggtgtg 600 cacaccttcc cagctgtcct gcagtctgac ctctacaccc tcagcagctc agtgactgta 660 acttcgagca cctggcccag ccagtccatc acctgcaatg tggcccaccc ggcaagcagc 720 accaaggtgg acaagaaaat tgagcccaga gggcccacaa tcaagccctg tcctccatgc 780 aaatgcccag cacctaacct cttgggtgga ccatccgtct tcatcttccc tccaaagatc 840 aaggatgtac tcatgatctc cctgagcccc atagtcacat gtgtggtggt ggatgtgagc 900 gaggatgacc cagatgtcca gatcagctgg tttgtgaaca acgtggaagt acacacagct 960 cagacacaaa cccatagaga ggattacaac agtactctcc gggtggtcag tgccctcccc 1020 atccagcacc aggactggat gagtggcaag gagttcaaat gcaaggtcaa caacaaagac 1080 ctcccagcgc ccatcgagag aaccatctca aaacccaaag ggtcagtaag agctccacag 1140 gtatatgtct tgcctccacc agaagaagag atgactaaga aacaggtcac tctgacctgc 1200 atggtcacag acttcatgcc tgaagacatt tacgtggagt ggaccaacaa cgggaaaaca 1260 gagctaaact acaagaacac tgaaccagtc ctggactctg atggttctta cttcatgtac 1320 agcaagctga gagtggaaaa gaagaactgg gtggaaagaa atagctactc ctgttcagtg 1380 gtccacgagg gtctgcacaa tcaccacacg actaagagct tctcccggac tccgggtaaa 1440 tgatctaga 1449 < 210 > 241 < 211 > 476 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 64 - Heavy variable < 400 > 241 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Gly Thr Gly Arg Ala Met Leu 35 40 45 Gly Thr His Thr Met Glu Val Thr Val Tyr His Trp Val Arg Gln Ala 50 55 60 Pro Gly Lys Gly Leu Glu Trp Ile Ala Tyr Ile Gly Ser Gly Gly Ser 65 70 75 80 Val Tyr Asp Phe Phe Val Trp Leu Arg Phe Thr Ile Ser Arg Asp Asn 85 90 95 Ser Lys Asn Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp 100 105 110 Thr Ala Val Tyr Tyr Cys Ala Arg Trp Asn Arg Gln Leu Tyr Pro Glu 115 120 125 Trp Thr Glu Ala Gln Arg Leu Asp Trp Gly Gln Gly Thr Thr Val Thr 130 135 140 Val Ser Ser Ala Lys Thr Thr Ala Pro Ser Val Tyr Pro Leu Ala Pro 145 150 155 160 Val Cys Gly Asp Thr Thr Gly Ser Ser Val Thr Leu Gly Cys Leu Val 165 170 175 Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr Trp Asn Ser Gly Ser 180 185 190 Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 195 200 205 Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser Ser Thr Trp Pro Ser 210 215 220 Gln Ser Ile Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 225 230 235 240 Asp Lys Lys Ile Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro 245 250 255 Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Pro Ser Val Phe Ile Phe 260 265 270 Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val 275 280 285 Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile 290 295 300 Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr 305 310 315 320 His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro 325 330 335 Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val 340 345 350 Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro 355 360 365 Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu 370 375 380 Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp 385 390 395 400 Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr 405 410 415 Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser 420 425 430 Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu 435 440 445 Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His 450 455 460 His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 465 470 475 < 210 > 242 < 211 > 738 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 64 - light variable < 400 > 242 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctccatct cttgcagatc tagtcagagc ctggtacata gtaatggaaa cacctattta 180 gaatggtacc tgcagaaacc aggccagtct ccacagctcc tgatctacaa agtttccaac 240 cgattttctg gggtcccaga cagattcagt ggcagtggat cagggacaga tttcacactc 300 aagatcagca gagtggaggc tgaggatacc ggagtgtatt actgctttca aggttcacat 360 gttccgtgga cgttcggtgg aggcaccaag gtggaaatca agcgtgcaga tgctgcacca 420 actgtatcga tcttcccacc atccagtgag cagttaacat ctggaggtgc ctcagtcgtg 480 tgcttcttga acaacttcta ccccaaagac atcaatgtca agtggaagat tgatggcagt 540 gaacgacaaa atggcgtcct gaacagttgg actgatcagg acagcaaaga cagcacctac 600 agcatgagca gcaccctcac gttgaccaag gacgagtatg aacgacataa cagctatacc 660 tgtgaggcca ctcacaagac atctacttca cccattgtca agagcttcaa caggaatgag 720 tgttagctcg agtctaga 738 < 210 > 243 < 211 > 238 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 64 - light variable < 400 > 243 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 35 40 45 Val His Ser Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro 50 55 60 Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 65 70 75 80 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 85 90 95 Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys 100 105 110 Phe Gln Gly Ser His Val Pro Trp Thr Phe Gly Gly Gly Thr Lys Val 115 120 125 Glu Ile Lys Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro 130 135 140 Ser Ser Glu Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu 145 150 155 160 Asn Asn Phe Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly 165 170 175 Ser Glu Arg Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser 180 185 190 Lys Asp Ser Thr Tyr Ser Met Ser Ser Thr Leu Thr Leu Thr Lys Asp 195 200 205 Glu Tyr Glu Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr 210 215 220 Ser Thr Ser Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 225 230 235 < 210 > 244 < 211 > 453 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 68 - heavy variable < 400 > 244 aagcttacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactcccagg tgcagctggt ggagactggg ggaggcttaa tccagcctgg agggtccctg 120 agaatgtcct gcgggacagg cagggcaatg ctgggcacac acaccatgga agtaactgtc 180 taccattggg ttcggcaggc tccggggaag gggctggagt ggatcgcata cattggtagt 240 ggtggtagtg tttatgattt ttttgtgtgg ctccgattca ccatttccag agacaatagc 300 aagaacaccc tgtatttgca attgaacagt ctgagggctg aggacacagc cgtgtattac 360 tgtgcccgat ggaacaggca gctgtatcca gagtggacag aagcccagag acttgactgg 420 ggccaaggta ccacggtcac cgtctccagc gct 453 < 210 > 245 < 211 > 147 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 68 - heavy variable < 400 > 245 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Gln Val Gln Leu Val Glu Thr Gly Gly Gly Leu Ile Gln 20 25 30 Pro Gly Gly Ser Leu Arg Met Ser Cys Gly Thr Gly Arg Ala Met Leu 35 40 45 Gly Thr His Thr Met Glu Val Thr Val Tyr His Trp Val Arg Gln Ala 50 55 60 Pro Gly Lys Gly Leu Glu Trp Ile Ala Tyr Ile Gly Ser Gly Gly Ser 65 70 75 80 Val Tyr Asp Phe Phe Val Trp Leu Arg Phe Thr Ile Ser Arg Asp Asn 85 90 95 Ser Lys Asn Thr Leu Tyr Leu Gln Leu Asn Ser Leu Arg Ala Glu Asp 100 105 110 Thr Ala Val Tyr Tyr Cys Ala Arg Trp Asn Arg Gln Leu Tyr Pro Glu 115 120 125 Trp Thr Glu Ala Gln Arg Leu Asp Trp Gly Gln Gly Thr Thr Val Thr 130 135 140 Val Ser Ser 145 < 210 > 246 < 211 > 435 < 212 > DNA < 213 > Unknown < 220 > < 223 > Sequence of DCIB 68 - light variable < 400 > 246 ggatccacca tgggatggag ctgtatcatc ctcttcttgg tagcaacagc taccggagtc 60 cactccgatg tgttgatgac ccaatctcca ctctccctgc ctgtcactcc tggggagcca 120 gcctcgatct cttgctggaa caggcagctg tatccagagt ggacagaagc ccagagactt 180 gactggtatc tgcagaaacc aggccagtct ccacagctcc tgatctacaa agtttccaac 240 cgattttctg gggtcccaga cagattcagt ggcagtggat cagggacaga tttcacactc 300 aagatcagca gagtggaggc tgaggatacc ggagtgtatt actgcgggac aggcagggca 360 atgctgggca cacacaccat ggaagtgact gtctaccatt tcggtggagg caccaaggtg 420 gaaatcaagc gtacg 435 < 210 > 247 < 211 > 140 < 212 > PRT < 213 > Unknown < 220 > < 223 > Sequence of DCIB 68 - light variable < 400 > 247 Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 1 5 10 15 Val His Ser Asp Val Leu Met Thr Gln Ser Pro Leu Ser Leu Pro Val 20 25 30 Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Trp Asn Arg Gln Leu Tyr 35 40 45 Pro Glu Trp Thr Glu Ala Gln Arg Leu Asp Trp Tyr Leu Gln Lys Pro 50 55 60 Gly Gln Ser Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 65 70 75 80 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 85 90 95 Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Thr Gly Val Tyr Tyr Cys 100 105 110 Gly Thr Gly Arg Ala Met Leu Gly Thr His Thr Met Glu Val Thr Val 115 120 125 Tyr His Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 130 135 140