SEQUENCE LISTING < 110 > ELLIS Jonathan Henry FORD Susannah Karen GERMASCHEWSKI Volker SODEN Peter Ernest WATTAM Trevor Anthony Kenneth ALARD Philippe Marc Louis LEWIS Alan THOMAS Pamela Joan < 120 > Antigen Binding Proteins < 130 > PB 62764 < 140 > PCT / EP 2008 / 067138 < 141 > 2008 - 12 - 09 < 150 > GB 0724185 . 4 < 151 > 2007 - 12 - 11 < 150 > GB 0806230 . 9 < 151 > 2008 - 04 - 04 < 150 > US 61 / 043839 < 151 > 2008 - 04 - 10 < 160 > 73 < 170 > FastSEQ for Windows Version 4 . 0 < 210 > 1 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > CDRH 1 aa < 400 > 1 Val Tyr Tyr Val His 1 5 < 210 > 2 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > CDRH 2 aa < 400 > 2 Arg Ile Asp Pro Glu Asn Gly Glu Thr Ile Tyr Thr Pro Lys Phe Gln 1 5 10 15 Asp < 210 > 3 < 211 > 3 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > CDRH 3 aa < 400 > 3 Ser Gly Tyr 1 < 210 > 4 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > CDRL 1 aa < 400 > 4 Arg Ser Ser Lys Ser Leu Leu His Arg Asn Gly Ile Thr Tyr Leu Tyr 1 5 10 15 < 210 > 5 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > CDRL 2 aa < 400 > 5 Gln Met Ser Asn Leu Ala Ser 1 5 < 210 > 6 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > CDRL 3 aa < 400 > 6 Ala Gln Asn Leu Glu Leu Trp Thr 1 5 < 210 > 7 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > peptide conjugate containing beta amyloid residues 27 - 38 used for immunisation and screening < 400 > 7 Cys Gly Gly Gly Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly 1 5 10 15 < 210 > 8 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Assay peptide containing beta amyloid residues 24 - 34 < 400 > 8 Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu 1 5 10 < 210 > 9 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Epitope mapping peptide containing beta amyloid residues 28 - 35 < 400 > 9 Lys Gly Ala Ile Ile Gly Leu Met 1 5 < 210 > 10 < 211 > 15 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Epitope mapping peptide containing beta amyloid residues 24 - 35 < 400 > 10 Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu Met Gly Ser Gly 1 5 10 15 < 210 > 11 < 211 > 15 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Epitope mapping peptide containing beta amyloid residues 28 - 39 < 400 > 11 Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Gly Ser Gly 1 5 10 15 < 210 > 12 < 211 > 15 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Epitope mapping peptide containing beta amyloid residues 31 - 42 < 400 > 12 Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala Gly Ser Gly 1 5 10 15 < 210 > 13 < 211 > 98 < 212 > PRT < 213 > Homo Sapiens < 400 > 13 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Val Ser Gly Tyr Thr Leu Thr Glu Leu 20 25 30 Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Met 35 40 45 Gly Gly Phe Asp Pro Glu Asp Gly Glu Thr Ile Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Met Thr Glu Asp Thr Ser Thr Asp Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Thr < 210 > 14 < 211 > 294 < 212 > DNA < 213 > Homo sapiens < 400 > 14 caggtccagc tggtacagtc tggggctgag gtgaagaagc ctggggcctc agtgaaggtc 60 tcctgcaagg tttccggata caccctcact gaattatcca tgcactgggt gcgacaggct 120 cctggaaaag ggcttgagtg gatgggaggt tttgatcctg aagatggtga aacaatctac 180 gcacagaagt tccagggcag agtcaccatg accgaggaca catctacaga cacagcctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgc aaca 294 < 210 > 15 < 211 > 15 < 212 > PRT < 213 > Homo sapiens < 400 > 15 Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 1 5 10 15 < 210 > 16 < 211 > 100 < 212 > PRT < 213 > Homo sapiens < 400 > 16 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro 100 < 210 > 17 < 211 > 300 < 212 > DNA < 213 > Homo sapiens < 400 > 17 gatattgtga tgactcagtc tccactctcc ctgcccgtca cccctggaga gccggcctcc 60 atctcctgca ggtctagtca gagcctcctg catagtaatg gatacaacta tttggattgg 120 tacctgcaga agccagggca gtctccacag ctcctgatct atttgggttc taatcgggcc 180 tccggggtcc ctgacaggtt cagtggcagt ggatcaggca cagattttac actgaaaatc 240 agcagagtgg aggctgagga tgttggggtt tattactgca tgcaagctct acaaactcct 300 < 210 > 18 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 400 > 18 Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 1 5 10 < 210 > 19 < 211 > 112 < 212 > PRT < 213 > Mus musculus < 400 > 19 Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Glu Pro Gly Ala 1 5 10 15 Ser Val Lys Leu Ser Cys Thr Gly Ser Gly Phe Asn Ile Lys Val Tyr 20 25 30 Tyr Val His Trp Leu Lys Gln Leu Thr Glu Gln Gly Leu Glu Trp Ile 35 40 45 Gly Arg Ile Asp Pro Glu Asn Gly Glu Thr Ile Tyr Thr Pro Lys Phe 50 55 60 Gln Asp Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 65 70 75 80 Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Ala Ala Val Tyr Tyr Cys 85 90 95 Val Ser Ser Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 100 105 110 < 210 > 20 < 211 > 336 < 212 > DNA < 213 > Mus musculus < 400 > 20 gaggttcagc tgcagcagtc tggggcagag cttgtggagc caggggcctc agtcaagttg 60 tcctgcacag gttctggctt caacattaag gtctactatg tgcactggct gaagcagttg 120 actgagcagg gcctggaatg gattggaagg attgatcctg aaaatggtga aactatatat 180 accccgaaat tccaggacaa ggccactttg acagtagaca catcatccaa cacagcctac 240 ctgcagctca gcagcctgac atctgaggac gctgccgtgt actattgtgt tagttcgggc 300 tactggggcc aaggcaccac tctcacagtc tcctca 336 < 210 > 21 < 211 > 111 < 212 > PRT < 213 > Mus musculus < 400 > 21 Asp Ile Val Met Thr Gln Ser Ala Phe Ser Asn Pro Val Thr Leu Gly 1 5 10 15 Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Arg 20 25 30 Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Pro 35 40 45 Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Thr Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 85 90 95 Leu Glu Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 < 210 > 22 < 211 > 333 < 212 > DNA < 213 > Mus musculus < 400 > 22 gatattgtga tgacgcagtc tgcattctcc aatccagtca ctcttggaac atcagcttcc 60 atctcctgca ggtctagcaa gagtctccta cataggaatg gcatcaccta tttgtattgg 120 tatctgcaga agccaggcca gcctcctcaa ctcctgattt atcagatgtc caaccttgcc 180 tcaggagtcc cagacaggtt cactagcagt gggtcaggaa ctgatttcac tctgaaaatc 240 agcagagtgg aggctgagga tgtgggtgtt tattactgtg ctcaaaatct agaactttgg 300 acgttcggtg gaggcaccaa gctggaaatc aaa 333 < 210 > 23 < 211 > 336 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > H 11 VH DNA < 400 > 23 caggtccagc tggtacagtc tggggctgag gtgaaggagc ctggggcctc agtgaaggtc 60 tcctgcaagg gttccggatt caacattaag gtctactatg tgcactggct gcgacagctt 120 cctggaaaag ggcttgagtg gatcggaagg attgatcctg aaaatggtga aactatatat 180 accccgaaat tccaggacaa ggccaccttg accgtagaca catctacaga cacagcctac 240 atggagctga gcagcctgag atctgaggac acggccgtgt attactgtgt tagttcgggc 300 tactggggcc agggcacact agtgaccgtg tccagc 336 < 210 > 24 < 211 > 112 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > H 11 VH aa < 400 > 24 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Glu Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Gly Ser Gly Phe Asn Ile Lys Val Tyr 20 25 30 Tyr Val His Trp Leu Arg Gln Leu Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Arg Ile Asp Pro Glu Asn Gly Glu Thr Ile Tyr Thr Pro Lys Phe 50 55 60 Gln Asp Lys Ala Thr Leu Thr Val Asp Thr Ser Thr Asp Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Ser Ser Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 100 105 110 < 210 > 25 < 211 > 333 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > L 9 VL DNA < 400 > 25 gatattgtga tgactcagtc tccactctcc aatcccgtca cccctggaga gccggcctcc 60 atctcctgca ggtctagcaa gagtctccta cataggaatg gcatcaccta tttgtattgg 120 tacctgcaga agccagggca gtctccacag ctcctgatct atcagatgtc caaccttgcc 180 tcaggggtcc ctgacaggtt cagtagcagt ggatcaggca cagattttac actgaaaatc 240 agcagagtgg aggctgagga tgttggggtt tattactgcg ctcaaaatct agaactttgg 300 acgttcggcc aagggaccaa ggtggaaatc aaa 333 < 210 > 26 < 211 > 111 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > L 9 VL aa < 400 > 26 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Asn Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Arg 20 25 30 Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 85 90 95 Leu Glu Leu Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 < 210 > 27 < 211 > 442 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > H 11 heavy chain aa < 400 > 27 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Glu Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Gly Ser Gly Phe Asn Ile Lys Val Tyr 20 25 30 Tyr Val His Trp Leu Arg Gln Leu Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Arg Ile Asp Pro Glu Asn Gly Glu Thr Ile Tyr Thr Pro Lys Phe 50 55 60 Gln Asp Lys Ala Thr Leu Thr Val Asp Thr Ser Thr Asp Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Ser Ser Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 100 105 110 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 115 120 125 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 130 135 140 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 145 150 155 160 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 165 170 175 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 180 185 190 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 195 200 205 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 210 215 220 Pro Ala Pro Glu Leu Ala Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 225 230 235 240 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 245 250 255 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 260 265 270 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 275 280 285 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 290 295 300 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 305 310 315 320 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 325 330 335 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 340 345 350 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 355 360 365 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 370 375 380 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 385 390 395 400 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 405 410 415 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 420 425 430 Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 435 440 < 210 > 28 < 211 > 218 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > L 9 heavy chain aa < 400 > 28 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Asn Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Arg 20 25 30 Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 85 90 95 Leu Glu Leu Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 100 105 110 Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 115 120 125 Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 130 135 140 Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 145 150 155 160 Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 165 170 175 Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 180 185 190 His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 195 200 205 Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 < 210 > 29 < 211 > 1326 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > H 11 heavy chain DNA ( optimised ) < 400 > 29 caggtgcagc tcgtgcagag cggcgccgag gtgaaagaac ccggcgccag cgtgaaggtg 60 agctgcaagg gcagcggctt caacatcaaa gtgtactacg tgcactggct gaggcagctg 120 cccggaaagg gcctggagtg gattggcagg atcgaccccg agaacggcga gaccatctac 180 acccccaagt tccaggacaa ggccaccctg accgtggaca ccagcaccga caccgcctac 240 atggaactga gcagcctgag gtccgaggat accgccgtct actactgcgt gagcagcggg 300 tattggggcc agggcacact agtgaccgtg agcagcgcca gcaccaaggg ccccagcgtg 360 ttccccctgg cccccagcag caagagcacc agcggcggca cagccgccct gggctgcctg 420 gtgaaggact acttccccga gcccgtgacc gtgtcctgga acagcggagc cctgacaagc 480 ggggtgcaca ccttccccgc cgtgctgcag agcagcggcc tgtacagcct gagcagcgtg 540 gtgacagtgc ccagcagcag cctgggcacc cagacctaca tctgcaacgt gaaccacaag 600 cccagcaaca ccaaggtgga caagaaggtg gagcccaaga gctgcgacaa gacccacacc 660 tgccccccct gccctgcccc tgaactggcc ggagccccct ccgtgttcct gttccccccc 720 aagcccaagg acaccctgat gatcagccgg acccccgagg tgacctgcgt ggtggtggac 780 gtgagccacg aggaccctga ggtgaagttc aattggtacg tggacggcgt ggaggtgcac 840 aacgccaaga ccaagccccg ggaggaacag tacaacagca cctaccgggt ggtgtccgtg 900 ctgaccgtgc tgcaccagga ctggctgaac ggcaaagaat acaagtgcaa ggtgtccaac 960 aaggccctgc ctgcccccat cgagaaaacc atcagcaagg ccaagggcca gcccagggaa 1020 ccccaggtgt acaccctgcc cccctcccgg gacgagctga ccaagaacca ggtgtccctg 1080 acctgtctgg tgaagggctt ctaccccagc gacatcgccg tggagtggga gagcaacggc 1140 cagcccgaga acaactacaa gaccaccccc cctgtgctgg acagcgacgg cagcttcttc 1200 ctgtacagca agctgaccgt ggacaagagc cggtggcagc agggcaacgt gttcagctgc 1260 agcgtgatgc acgaggccct gcacaaccac tacacccaga agagcctgag cctgtccccc 1320 ggcaag 1326 < 210 > 30 < 211 > 654 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > L 9 light chain DNA ( optimised ) < 400 > 30 gacatcgtga tgacccagag cccactgagc aatcccgtga ctcccggcga gcccgcctca 60 atcagctgca ggagcagcaa gagcctgctg cacaggaacg gcatcaccta cctgtactgg 120 tatctgcaga agcccggcca gagcccccag ctgctgatct accagatgtc caacctggcc 180 agcggcgtgc ccgaccggtt ctctagcagc ggaagcggca ccgacttcac cctgaagatc 240 agcagggtgg aagccgagga cgtgggcgtg tactactgcg cccagaacct ggagctctgg 300 accttcggcc agggcaccaa ggtggagatc aaacgtacgg tggccgcccc cagcgtgttc 360 atcttccccc ccagcgatga gcagctgaag agcggcaccg ccagcgtggt gtgtctgctg 420 aacaacttct acccccggga ggccaaggtg cagtggaagg tggacaatgc cctgcagagc 480 ggcaacagcc aggagagcgt gaccgagcag gacagcaagg actccaccta cagcctgagc 540 agcaccctga ccctgagcaa ggccgactac gagaagcaca aggtgtacgc ctgtgaggtg 600 acccaccagg gcctgtccag ccccgtgacc aagagcttca accggggcga gtgc 654 < 210 > 31 < 211 > 112 < 212 > PRT < 213 > Mus musculus < 400 > 31 Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Leu Ser Cys Thr Gly Ser Gly Phe Asn Ile Lys Val Tyr 20 25 30 Tyr Val His Trp Leu Lys Gln Leu Thr Glu Gln Gly Leu Glu Trp Ile 35 40 45 Gly Arg Ile Asp Pro Glu Asn Gly Glu Thr Ile Tyr Ala Pro Lys Phe 50 55 60 Gln Asp Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 65 70 75 80 Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Ser Ser Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 100 105 110 < 210 > 32 < 211 > 336 < 212 > DNA < 213 > Mus musculus < 400 > 32 gaggttcagc tacagcagtc tggggcagag cttgtgaagc caggggcctc agtcaagttg 60 tcctgcacag gttctggctt caacattaag gtctactatg tgcactggct gaagcagttg 120 actgagcagg gcctggaatg gattggaagg attgatcctg aaaatggtga aactatatat 180 gccccgaaat tccaggacaa ggccactttg acagtagaca catcatccaa cacagcctac 240 ctgcagctca gcagcctgac atctgaggac actgccgtct attattgtgt tagttcgggc 300 tactggggcc aaggcaccac tctcacagtc tcctca 336 < 210 > 33 < 211 > 111 < 212 > PRT < 213 > Mus musculus < 400 > 33 Asp Ile Val Met Thr Gln Ser Ala Phe Ser Asn Pro Val Thr Leu Gly 1 5 10 15 Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Arg 20 25 30 Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Thr Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 85 90 95 Leu Glu Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 < 210 > 34 < 211 > 333 < 212 > DNA < 213 > Mus musculus < 400 > 34 gatattgtga tgacgcagtc tgcattctcc aatccagtca ctcttggaac atcagcttcc 60 atctcctgca ggtctagtaa gagtctccta cataggaatg gcatcaccta tttgtattgg 120 tatctgcaga agccaggcca gtctcctcag ctcctgattt atcagatgtc caaccttgcc 180 tcaggagtcc cagacaggtt cactagcagt gggtcaggaa ctgatttcac tctgaaaatc 240 agcagagtgg aggctgagga tgtgggtgtt tattactgtg ctcaaaatct agaactttgg 300 acgttcggtg gaggcaccaa gctggaaatc aaa 333 < 210 > 35 < 211 > 112 < 212 > PRT < 213 > Mus musculus < 400 > 35 Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Val Tyr 20 25 30 Tyr Ile His Trp Leu Lys Gln Leu Thr Glu Gln Gly Leu Glu Trp Ile 35 40 45 Gly Arg Ile Asp Pro Glu Asn Gly Glu Thr Lys Tyr Val Pro Lys Phe 50 55 60 Gln Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 65 70 75 80 Leu His Leu Ser Ser Leu Thr Ser Glu Asp Thr Gly Val Tyr Tyr Cys 85 90 95 Val Thr Ser Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 100 105 110 < 210 > 36 < 211 > 336 < 212 > DNA < 213 > Mus musculus < 400 > 36 gaggttcagc tgcagcagtc tggggcagag gttgtgaagc caggggcctc agtcaagttg 60 tcctgcacag cttctggctt caacattaaa gtctactata tccactggtt gaagcagttg 120 actgagcagg gcctagaatg gattggaagg attgatcctg aaaatggtga aactaagtat 180 gtcccgaaat tccagggcaa ggccacttta acagtagaca catcctccaa cacagcctac 240 ctgcacctca gcagcctgac atctgaggac actggcgtct attactgtgt tacctcgggc 300 tactggggcc aaggcaccac tctcacagtc tcctca 336 < 210 > 37 < 211 > 111 < 212 > PRT < 213 > Mus musculus < 400 > 37 Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Ala Leu Gly 1 5 10 15 Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 20 25 30 Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 85 90 95 Leu Glu Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 < 210 > 38 < 211 > 333 < 212 > DNA < 213 > Mus musculus < 400 > 38 gatattgtga tgacgcaggc tgcattctcc aatccagtcg ctcttggaac atcagcttcc 60 atctcctgca ggtctagtaa gagtctccta catagtaatg gcatcactta tttgtattgg 120 tatctgcaga agccaggcca gtctcctcag ctcctgattt atcagatgtc caaccttgcc 180 tcaggagtcc cagacaggtt cagtagcagt gggtcaggaa ctgatttcac actgagaatc 240 agcagagtgg aggctgagga tgtgggtgtt tattactgtg ctcaaaatct agaactttgg 300 acgttcggtg gaggcaccaa gctggaaatc aaa 333 < 210 > 39 < 211 > 112 < 212 > PRT < 213 > Mus musculus < 400 > 39 Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Glu Pro Gly Ala 1 5 10 15 Ser Val Lys Leu Ser Cys Thr Gly Ser Gly Phe Asn Ile Lys Val Tyr 20 25 30 Tyr Val His Trp Leu Lys Gln Leu Thr Glu Gln Gly Leu Glu Trp Ile 35 40 45 Gly Arg Ile Asp Pro Glu Asn Gly Glu Thr Leu Tyr Thr Pro Lys Phe 50 55 60 Gln Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 65 70 75 80 Leu Gln Leu Asn Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Ser Ser Gly Tyr Trp Gly Gln Gly Thr Ser Leu Thr Val Ser Ser 100 105 110 < 210 > 40 < 211 > 336 < 212 > DNA < 213 > Mus musculus < 400 > 40 gaggttcagc tgcagcagtc tggggcagag cttgtggagc caggggcctc agtcaagttg 60 tcctgcacag gttctggctt caacattaag gtctactatg ttcactggct gaagcagttg 120 actgagcagg gcctggaatg gattggaagg attgatcctg agaatggtga aactctatac 180 accccgaaat tccagggcaa ggccactttg acagtagaca catcatccaa cacagcctac 240 ctgcagctca acagcctgac atctgaggac actgccgtct attattgtgt tagttcgggc 300 tactggggcc aaggcacctc tctcacagtc tcctca 336 < 210 > 41 < 211 > 111 < 212 > PRT < 213 > Mus musculus < 400 > 41 Asp Ile Val Met Thr Gln Ser Ala Phe Ser Asn Pro Val Thr Leu Gly 1 5 10 15 Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Arg 20 25 30 Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Thr Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 85 90 95 Leu Glu Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 < 210 > 42 < 211 > 333 < 212 > DNA < 213 > Mus musculus < 400 > 42 gatattgtga tgacgcagtc tgcattctcc aatccagtca ctcttggaac atcagcttcc 60 atctcctgca ggtctagcaa gagtctccta cataggaatg gcatcaccta tttgtattgg 120 tatctgcaga agccaggcca gtctcctcag ctcctgattt atcagatgtc caaccttgcc 180 tcaggagtcc cagacaggtt cactagcagt gggtcaggaa ctgatttcac tctgaaaatc 240 agcagagtgg aggctgagga tgtgggtgtt tattactgtg ctcaaaatct agaactttgg 300 acgttcggtg gaggcaccaa gctggaaatc aaa 333 < 210 > 43 < 211 > 112 < 212 > PRT < 213 > Mus musculus < 400 > 43 Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Phe Val Arg Pro Gly Ala 1 5 10 15 Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Thr Tyr 20 25 30 Tyr Ile His Trp Leu Lys Gln Arg Thr Asp Gln Gly Leu Glu Trp Ile 35 40 45 Gly Arg Ile Asp Pro Glu Asp Gly Glu Thr Lys Phe Gly Pro Lys Phe 50 55 60 Arg Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Ser 65 70 75 80 Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Gly Val Tyr Tyr Cys 85 90 95 Val Thr Ser Gly Tyr Trp Gly Gln Gly Thr Thr Leu Ser Val Ser Ser 100 105 110 < 210 > 44 < 211 > 336 < 212 > DNA < 213 > Mus musculus < 400 > 44 gaggttcagc tgcagcagtc tggggcagag tttgtgaggc caggggcctc agtcaagtta 60 tcctgcacag cttctggctt caacattaaa acctactata tacactggct gaaacagagg 120 actgaccagg gcctggagtg gattggaagg attgatcccg aggatggtga aactaaattt 180 ggcccgaaat tccggggcaa ggccacttta acagcagaca catcctccaa cacagcctcc 240 ctacaactca gcagtctgac atctgaggac actggcgtct attactgtgt tacctcgggc 300 tactggggcc aaggcaccac tctctcagtc tcctca 336 < 210 > 45 < 211 > 111 < 212 > PRT < 213 > Mus musculus < 400 > 45 Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 1 5 10 15 Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 20 25 30 Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 85 90 95 Leu Glu Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 < 210 > 46 < 211 > 333 < 212 > DNA < 213 > Mus musculus < 400 > 46 gatattgtga tgacgcaggc tgcattctcc aatccagtca ctcttggaac atcagcctcc 60 atctcctgca ggtctagtaa gagtctccta catagtaatg gcatcactta tttgtattgg 120 tatctgcaga agccaggcca gtctcctcag ctcttgattt atcagatgtc caaccttgcc 180 tcaggagtcc cagacaggtt cagtagcagt gggtcaggaa ctgatttcac actgagaatc 240 agcagagtgg aggctgagga tgtgggtgtt tattactgtg ctcaaaatct agaactttgg 300 acgttcggtg gaggcaccaa gctggaaatc aaa 333 < 210 > 47 < 211 > 112 < 212 > PRT < 213 > Mus musculus < 400 > 47 Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Leu Ser Cys Thr Gly Ser Gly Phe Asn Ile Lys Val Tyr 20 25 30 Tyr Val His Trp Leu Lys Gln Leu Thr Glu Gln Gly Leu Glu Trp Ile 35 40 45 Gly Arg Ile Asp Pro Glu Asn Gly Glu Thr Lys Tyr Ala Pro Lys Phe 50 55 60 Gln Asp Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 65 70 75 80 Leu His Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Ser Ser Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 100 105 110 < 210 > 48 < 211 > 336 < 212 > DNA < 213 > Mus musculus < 400 > 48 gaggttcagc tgcagcagtc tggggcagag cttgtgaagc caggggcctc agtcaagttg 60 tcctgcacag gttctggctt caacattaag gtctactatg tgcactggct gaagcagttg 120 actgagcagg gcctggaatg gattggaagg attgatcctg aaaatggtga aactaaatat 180 gccccgaaat tccaggacaa ggccactttg acagtagaca catcctccaa tacagcctac 240 cttcacctca gcagcctgac atctgaggac actgccgtct attattgtgt tagttcgggc 300 tactggggcc aaggcaccac tctcacagtc tcctca 336 < 210 > 49 < 211 > 111 < 212 > PRT < 213 > Mus musculus < 400 > 49 Asp Ile Val Met Thr Gln Ser Ala Phe Ser Asn Pro Val Thr Leu Gly 1 5 10 15 Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Arg 20 25 30 Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Thr Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 85 90 95 Leu Glu Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 < 210 > 50 < 211 > 333 < 212 > DNA < 213 > Mus musculus < 400 > 50 gacattgtga tgacgcagtc tgcattctcc aatccagtca ctcttggaac atcagcttcc 60 atctcctgca ggtctagtaa gagtctccta cataggaatg gcatcaccta tttgtattgg 120 tatctgcaga agccaggcca gtctcctcag ctcctgattt atcagatgtc caaccttgcc 180 tcaggagtcc cagacaggtt cactagcagt gggtcaggaa ctgatttcac tctgaaaatc 240 agcagagtgg aggctgagga tgtgggtgtt tattattgtg ctcaaaatct agaactttgg 300 acgttcggtg gaggcaccaa gctggaaatc aaa 333 < 210 > 51 < 211 > 112 < 212 > PRT < 213 > Mus musculus < 400 > 51 Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Glu Pro Gly Ala 1 5 10 15 Ser Val Lys Leu Ser Cys Thr Gly Ser Gly Phe Asn Ile Lys Val Tyr 20 25 30 Tyr Val His Trp Leu Lys Gln Leu Thr Glu Gln Gly Leu Glu Trp Ile 35 40 45 Gly Arg Ile Asp Pro Glu Asn Gly Glu Thr Leu Tyr Thr Pro Lys Phe 50 55 60 Gln Gly Lys Ala Thr Phe Thr Val Asp Thr Ser Ser Asn Thr Ala Tyr 65 70 75 80 Leu Gln Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Ser Ser Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 100 105 110 < 210 > 52 < 211 > 336 < 212 > DNA < 213 > Mus musculus < 400 > 52 gaggttcagc tgcagcagtc tggggcagag cttgtggagc caggggcctc agtcaagttg 60 tcctgcacag gttctggctt caacattaag gtctactatg ttcactggct gaagcagttg 120 actgagcagg gcctggaatg gattggaagg attgatcctg agaatggtga aactctatat 180 accccgaaat tccagggcaa ggccactttt acagtagaca catcatccaa cacagcctac 240 ctgcagctca gcagcctgac atctgaggac actgccgtct attattgtgt tagttcgggc 300 tactggggcc aaggcaccac tctcacagtc tcctca 336 < 210 > 53 < 211 > 111 < 212 > PRT < 213 > Mus musculus < 400 > 53 Asp Ile Val Met Thr Gln Ser Ala Phe Ser Asn Pro Val Thr Leu Gly 1 5 10 15 Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Arg 20 25 30 Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Thr Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 85 90 95 Leu Glu Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 < 210 > 54 < 211 > 333 < 212 > DNA < 213 > Mus musculus < 400 > 54 gatattgtga tgacgcagtc tgcattctcc aatccagtca ctcttggaac atcagcttcc 60 atctcctgca ggtctagcaa gagtctccta cataggaatg gcatcaccta tttgtattgg 120 tatctgcaga agccaggcca gtctcctcag ctcctgattt atcagatgtc caaccttgcc 180 tcaggagtcc cagacaggtt cactagcagt gggtcaggaa ctgatttcac tctgaaaatc 240 agcagagtgg aggctgagga tgtgggtgtt tattactgtg ctcaaaatct agaactttgg 300 acgttcggtg gaggcaccaa gctggaaatc aaa 333 < 210 > 55 < 211 > 112 < 212 > PRT < 213 > Mus musculus < 400 > 55 Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Tyr 20 25 30 Tyr Met His Trp Leu Lys Gln Leu Thr Glu Gln Gly Leu Glu Trp Ile 35 40 45 Gly Arg Ile Asp Pro Glu Asn Gly Glu Thr Gln Tyr Ala Pro Lys Phe 50 55 60 Gln Gly Lys Ala Ser Leu Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 65 70 75 80 Leu His Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Ser Ser Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr Val Ser Ser 100 105 110 < 210 > 56 < 211 > 336 < 212 > DNA < 213 > Mus musculus < 400 > 56 gaggttcagc tgcagcagtc tggggcagag cttgtgaagc caggggcctc agtcaagttg 60 tcctgcacag cttctggctt caacattaaa gactactata tgcactggtt gaagcagttg 120 actgagcagg gcctggaatg gattggaagg attgatcctg aaaatggtga aactcaatat 180 gccccgaaat tccagggcaa ggcctcttta acagcagaca catcctccaa cacagcctac 240 cttcacctca gcagcctgac atctgaggac actgccgtct attactgtgt tagttcgggc 300 tactggggcc aaggcaccac tctcacagtc tcctca 336 < 210 > 57 < 211 > 111 < 212 > PRT < 213 > Mus musculus < 400 > 57 Asp Ile Val Met Thr Gln Ala Ala Phe Ser Asn Pro Val Thr Leu Gly 1 5 10 15 Thr Ser Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Ser 20 25 30 Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Gln Met Ser Asn Leu Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Arg Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 85 90 95 Leu Glu Leu Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 < 210 > 58 < 211 > 333 < 212 > DNA < 213 > Mus musculus < 400 > 58 gatattgtga tgacgcaggc tgcattctcc aatccagtca ctcttggaac atcagcttcc 60 atctcctgca ggtctagtaa gagtctccta catagtaatg gcatcactta tttgtattgg 120 tatctgcaga agccaggcca gtctcctcag ctcctgattt atcagatgtc caaccttgcc 180 tcaggagtcc cagacaggtt cagtagcagt gggtcaggaa ctgatttcac actgagaatc 240 agcagagtgg aggctgagga tgtgggtgtt tattactgtg ctcaaaatct agaactttgg 300 acgttcggtg gaggcaccaa gctggaaatc aaa 333 < 210 > 59 < 211 > 112 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > H 48 heavy chain aa < 400 > 59 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Glu Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Gly Ser Gly Phe Asn Ile His Val Tyr 20 25 30 Tyr Val His Trp Leu Arg Gln Leu Pro Glu Lys Gly Leu Glu Trp Ile 35 40 45 Gly Arg Ile Asp Pro Glu Asn Gly Glu Thr Ile Tyr Thr Pro Lys Phe 50 55 60 Gln Asp Lys Ala Thr Leu Thr Val Asp Thr Ser Thr Asp Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Ser Ser Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 100 105 110 < 210 > 60 < 211 > 336 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > H 48 heavy chain DNA < 400 > 60 caggtgcagc tcgtgcagag cggcgccgag gtgaaagaac ccggcgccag cgtgaaggtg 60 agctgcaagg gcagcggctt caacatccac gtgtactacg tgcactggct gaggcagctg 120 cccgagaagg gcctggagtg gattggcagg atcgaccccg agaacggcga gaccatctac 180 acccccaagt tccaggacaa ggccaccctg accgtggaca ccagcaccga caccgcctac 240 atggaactga gcagcctgag gtccgaggat accgccgtct actactgcgt gagcagcggg 300 tattggggcc agggcacact agtgaccgtg tccagc 336 < 210 > 61 < 211 > 112 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > H 49 heavy chain aa < 400 > 61 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Glu Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Gly Ser Gly Phe Asn Ile Lys Thr Tyr 20 25 30 Tyr Val His Trp Leu Arg Gln Leu Pro Glu Lys Gly Leu Glu Trp Ile 35 40 45 Gly Arg Ile Asp Pro Glu Asn Gly Glu Thr Ile Tyr Thr Pro Lys Phe 50 55 60 Gln Asp Lys Ala Thr Leu Thr Val Asp Thr Ser Thr Asp Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Ser Ser Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 100 105 110 < 210 > 62 < 211 > 336 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > H 49 heavy chain DNA < 400 > 62 caggtgcagc tcgtgcagag cggcgccgag gtgaaagaac ccggcgccag cgtgaaggtg 60 agctgcaagg gcagcggctt caacatcaaa acctactacg tgcactggct gaggcagctg 120 cccgagaagg gcctggagtg gattggcagg atcgaccccg agaacggcga gaccatctac 180 acccccaagt tccaggacaa ggccaccctg accgtggaca ccagcaccga caccgcctac 240 atggaactga gcagcctgag gtccgaggat accgccgtct actactgcgt gagcagcggg 300 tattggggcc agggcacact agtgaccgtg tccagc 336 < 210 > 63 < 211 > 112 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > H 50 heavy chain aa < 400 > 63 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Glu Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Thr Gly Ser Gly Phe Asn Ile His Val Tyr 20 25 30 Tyr Val His Trp Leu Arg Gln Leu Pro Glu Lys Gly Leu Glu Trp Ile 35 40 45 Gly Arg Ile Asp Pro Glu Asn Gly Glu Thr Ile Tyr Thr Pro Lys Phe 50 55 60 Gln Asp Lys Ala Thr Leu Thr Val Asp Thr Ser Thr Asp Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Ser Ser Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 100 105 110 < 210 > 64 < 211 > 336 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > H 50 heavy chain DNA < 400 > 64 caggtgcagc tcgtgcagag cggcgccgag gtgaaagaac ccggcgccag cgtgaaggtg 60 agctgcaccg gcagcggctt caacatccac gtgtactacg tgcactggct gaggcagctg 120 cccgagaagg gcctggagtg gattggcagg atcgaccccg agaacggcga gaccatctac 180 acccccaagt tccaggacaa ggccaccctg accgtggaca ccagcaccga caccgcctac 240 atggaactga gcagcctgag gtccgaggat accgccgtct actactgcgt gagcagcggg 300 tattggggcc agggcacact agtgaccgtg tccagc 336 < 210 > 65 < 211 > 112 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > H 51 heavy chain aa < 400 > 65 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Glu Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Gly Ser Gly Phe Asn Ile His Thr Tyr 20 25 30 Tyr Val His Trp Leu Arg Gln Leu Pro Glu Lys Gly Leu Glu Trp Ile 35 40 45 Gly Arg Ile Asp Pro Glu Asn Gly Glu Thr Ile Tyr Thr Pro Lys Phe 50 55 60 Gln Asp Lys Ala Thr Leu Thr Val Asp Thr Ser Thr Asp Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Val Ser Ser Gly Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 100 105 110 < 210 > 66 < 211 > 336 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > H 51 heavy chain DNA < 400 > 66 caggtgcagc tcgtgcagag cggcgccgag gtgaaagaac ccggcgccag cgtgaaggtg 60 agctgcaagg gcagcggctt caacatccac acctactacg tgcactggct gaggcagctg 120 cccgagaagg gcctggagtg gattggcagg atcgaccccg agaacggcga gaccatctac 180 acccccaagt tccaggacaa ggccaccctg accgtggaca ccagcaccga caccgcctac 240 atggaactga gcagcctgag gtccgaggat accgccgtct actactgcgt gagcagcggg 300 tattggggcc agggcacact agtgaccgtg tccagc 336 < 210 > 67 < 211 > 111 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > L 19 light chain aa < 400 > 67 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Asn Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Arg 20 25 30 Asn Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Gln Met Asp His Leu Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 85 90 95 Leu Glu Leu Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 < 210 > 68 < 211 > 333 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > L 19 light chain DNA < 400 > 68 gacatcgtga tgacccagag cccactgagc aatcccgtga ctcccggcga gcccgcctca 60 atcagctgca ggagcagcaa gagcctgctg cacaggaacg gcaagaccta cctgtactgg 120 tatctgcaga agcccggcca gagcccccag ctgctgatct accagatgga ccacctggcc 180 agcggcgtgc ccgaccggtt ctctagcagc ggaagcggca ccgacttcac cctgaagatc 240 agcagggtgg aagccgagga cgtgggcgtg tactactgcg cccagaacct ggagctctgg 300 accttcggcc agggcaccaa ggtggagatc aaa 333 < 210 > 69 < 211 > 111 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > L 20 light chain aa < 400 > 69 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Asn Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Arg 20 25 30 Asn Gly Ile Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Gln Met Asp His Leu Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 85 90 95 Leu Glu Leu Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 < 210 > 70 < 211 > 333 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > L 20 light chain DNA < 400 > 70 gacatcgtga tgacccagag cccactgagc aatcccgtga ctcccggcga gcccgcctca 60 atcagctgca ggagcagcaa gagcctgctg cacaggaacg gcatcaccta cctgtactgg 120 tatctgcaga agcccggcca gagcccccag ctgctgatct accagatgga ccacctggcc 180 agcggcgtgc ccgaccggtt ctctagcagc ggaagcggca ccgacttcac cctgaagatc 240 agcagggtgg aagccgagga cgtgggcgtg tactactgcg cccagaacct ggagctctgg 300 accttcggcc agggcaccaa ggtggagatc aaa 333 < 210 > 71 < 211 > 111 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > L 21 light chain aa < 400 > 71 Asp Ile Val Met Thr Gln Ser Pro Leu Ser Asn Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Lys Ser Leu Leu His Arg 20 25 30 Asn Gly Lys Thr Tyr Leu Tyr Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Gln Met Asp Asn Leu Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Ser Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ala Gln Asn 85 90 95 Leu Glu Leu Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 < 210 > 72 < 211 > 333 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > L 21 light chain DNA < 400 > 72 gacatcgtga tgacccagag cccactgagc aatcccgtga ctcccggcga gcccgcctca 60 atcagctgca ggagcagcaa gagcctgctg cacaggaacg gcaagaccta cctgtactgg 120 tatctgcaga agcccggcca gagcccccag ctgctgatct accagatgga caacctggcc 180 agcggcgtgc ccgaccggtt ctctagcagc ggaagcggca ccgacttcac cctgaagatc 240 agcagggtgg aagccgagga cgtgggcgtg tactactgcg cccagaacct ggagctctgg 300 accttcggcc agggcaccaa ggtggagatc aaa 333 < 210 > 73 < 211 > 21 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > peptide conjugate containing beta amyloid residues 22 - 38 used for immunisation and screening < 400 > 73 Cys Gly Gly Gly Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly 1 5 10 15 Leu Met Val Gly Gly 20