Very good comment . One more situation in which not clearing is a good idea is when there are no enemies in the lane but they will probably rotate before you manage to push the wave into their towers . This way several of your creeps will die without giving the enemy team experience . <| sep |> Hi there ! In general , you ' ll use your retinoid at night , after cleansing . After a wait period , you can layer other products on top like toner , moisturizer , vaseline , etc . . I see a lot of people using their antibiotic like clindamyacin in the morning , again on a clean face . But I ' m assuming your derm has told you when and how often to use your meds , so go by that . Some other things you should know prescription retinoids like Adapalene can be pretty harsh on your skin in the first few months of use . And there are some things you can do to decrease the side effects , like buffering using moisturizer underneath the retinoid and layering petroleum jellyvaseline on top of your PM moisturizer . You should also build up the use of the retinoid product to reduce the chance of adverse reactions . And make sure you ' re using lots of sun protection in the AM , even in winter , because retinoids will greatly increase your sensitivity to the sun . I highly recommend reading Skinacea ' s Use Retinoids the Right Way Part Oneretinoidsrightpartone . html #. VMkrGiGn 8 , Part Tworetinoidsrightparttwo . html #. VKmsZHsYGwI and Retinoid Side Effects and P r ecautionseffectsretinoids . html #. VKmtLHsYGwI for more info on how to use retinoids properly . Let me know if you have more questions !