The chemicals primarily used are Colchicine and Oryzalin , colchicine in particular is very poisonous but oryzalin is a safer option for general lab use . Both are effectively microtubule inhibitors that retard mitosis of the germinating plantlets and allow for a small percentage to become polyploid . The chemicals are easily obtained from many chemical suppliers and last quite a long time without degrading . Provided some lab experience and proper ventilation procedures I don ' t think either chemical poses a significant risk , it ' s more often improper handling and storage that causes problems . <| sep |> i think everyone does now what a fool <| sep |> Same . When I see someone zipper merge properly I call It ' s always nice to hear something positive , we almost always only get feedback when we do something wrong , positive reenforcement is just as important