Interesting . A couple things about that study though As you said , the dosages were insane . They were also daily , and meth ' s longer half life may have played a role in its toxicity . Only certain markers of toxicity were measured dopamine and 5 HT terminals . It doesn ' t mean the study is bad , just not the complete picture . The dosages were equimolar . If we assume an MDMA dosage of 160 mg normal recreational use the equimolar dose of meth is 128 mg . 128 mg of oral meth without tolerance would be absolutely insane . Imagine comparing 100 mg of MDMA and 100 mg of LSD ~ 10000 hits , and concluding that the LSD is much more harmful after the population exhibits paranoia , psychosis , tachycardia , tremors , etc . <| sep |> ACTUALLY , IT PROVES THE OPPOSITE . WE HAVE THE WORDS LAKE , POND , AND PUDDLE , WHILE YOU CALL ALL THREE OF THOSE THINGS LAKES .