화합물 178 - E 2 LC / MS ESI 449 . 1 ( M + H ) +. 1 H NMR ( 500 MHz , MeOD ) δ 7 . 51 ( d , J = 7 . 6 Hz , 2 H ) , 7 . 41 ( d , J = 6 . 5 Hz , 3 H ) , 7 . 15 ( d , J = 7 . 1 Hz , 1 H ) , 6 . 51 ( d , J = 7 . 3 Hz , 1 H ) , 4 . 47 ( d , J = 13 . 4 Hz , 2 H ) , 4 . 19 ( s , 1 H ) , 3 . 86 ( M , 4 H ) , 3 . 64 ? 3 . 54 ( m , 1 H ) , 3 . 42 ? 3 . 37 ( m , 2 H ) , 2 . 98 ( t , J = 13 . 2 Hz , 1 H ) , 2 . 68 ( M , 3 H ) , 2 . 62 ? 2 . 38 ( m , 2 H ) , 1 . 96 ? 1 . 82 ( m , 3 H ) , 1 . 68 ( d , J = 13 . 0 Hz , 2 H ) , 1 . 12 ( M , 2 H ) . 키 랄 SFC A ( 45 % MeOH ) : ee 100 %, Rt = 3 . 57 분 .