< 110 > Genentech , Inc . F . Hoffman - La Roche AG < 120 > ANTI - TRYPTASE ANTIBODIES , COMPOSITIONS THEREOF , AND USES THEREOF < 130 > 50474 - 112 WO 2 < 150 > US 62 / 457 , 722 < 151 > 2017 - 02 - 10 < 160 > 128 < 170 > KoPatentIn version 3 . 0 < 210 > 1 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 220 > < 221 > MOD _ RES < 222 > ( 1 ) < 223 > X is Asp or Ser < 220 > < 221 > MOD _ RES < 222 > ( 2 ) < 223 > X is Tyr or Phe < 220 > < 221 > MOD _ RES < 222 > ( 5 ) < 223 > X is Val or His < 400 > 1 Xaa Xaa Gly Met Xaa 1 5 < 210 > 2 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 2 Phe Ile Ser Ser Gly Ser Ser Thr Val Tyr Tyr Ala Asp Thr Met Lys 1 5 10 15 Gly < 210 > 3 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 220 > < 221 > MOD _ RES < 222 > ( 2 ) < 223 > X is Asn or Asp < 220 > < 221 > MOD _ RES < 222 > ( 3 ) < 223 > X is Tyr or Asn < 220 > < 221 > MOD _ RES < 222 > ( 4 ) < 223 > X is Asp or Tyr < 400 > 3 Arg Xaa Xaa Xaa Asp Trp Tyr Phe Asp Val 1 5 10 < 210 > 4 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 4 Ser Ala Ser Ser Ser Val Thr Tyr Met Tyr 1 5 10 < 210 > 5 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 5 Arg Thr Ser Asp Leu Ala Ser 1 5 < 210 > 6 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 6 Gln His Tyr His Ser Tyr Pro Leu Thr 1 5 < 210 > 7 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 7 Asp Tyr Gly Met Val 1 5 < 210 > 8 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 8 Arg Asn Tyr Asp Asp Trp Tyr Phe Asp Val 1 5 10 < 210 > 9 < 211 > 119 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 9 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Phe Ile Ser Ser Gly Ser Ser Thr Val Tyr Tyr Ala Asp Thr Met 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Arg Asn Tyr Asp Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 < 210 > 10 < 211 > 106 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 10 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 20 25 30 Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Pro Trp Ile Tyr 35 40 45 Arg Thr Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 65 70 75 80 Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr His Ser Tyr Pro Leu Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 11 < 211 > 30 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 11 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 20 25 30 < 210 > 12 < 211 > 14 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 12 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 1 5 10 < 210 > 13 < 211 > 32 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 13 Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu Gln 1 5 10 15 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Thr Arg 20 25 30 < 210 > 14 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 14 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 1 5 10 < 210 > 15 < 211 > 23 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 15 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys 20 < 210 > 16 < 211 > 15 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 16 Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Pro Trp Ile Tyr 1 5 10 15 < 210 > 17 < 211 > 32 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 17 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 20 25 30 < 210 > 18 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 18 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 1 5 10 < 210 > 19 < 211 > 119 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 19 Glu Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 1 5 10 15 Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Phe Ile Ser Ser Gly Ser Ser Thr Val Tyr Tyr Ala Asp Thr Met 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe 65 70 75 80 Leu Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys 85 90 95 Ala Arg Arg Asp Asn Tyr Asp Trp Tyr Phe Asp Val Trp Gly Thr Gly 100 105 110 Thr Thr Val Thr Val Ser Ser 115 < 210 > 20 < 211 > 106 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 20 Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 1 5 10 15 Glu Lys Val Thr Ile Ser Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 20 25 30 Tyr Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 35 40 45 Arg Thr Ser Asp Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 65 70 75 80 Asp Ala Ala Thr Tyr Tyr Cys Gln His Tyr His Ser Tyr Pro Leu Thr 85 90 95 Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 100 105 < 210 > 21 < 211 > 30 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 21 Glu Val Lys Leu Val Glu Ser Gly Gly Gly Ser Val Gln Pro Gly Gly 1 5 10 15 Ser Arg Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser 20 25 30 < 210 > 22 < 211 > 14 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 22 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val Ala 1 5 10 < 210 > 23 < 211 > 32 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 23 Arg Phe Thr Ile Ser Arg Asp Asn Pro Lys Asn Thr Leu Phe Leu Gln 1 5 10 15 Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala Arg 20 25 30 < 210 > 24 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 24 Trp Gly Thr Gly Thr Thr Val Thr Val Ser Ser 1 5 10 < 210 > 25 < 211 > 23 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 25 Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 1 5 10 15 Glu Lys Val Thr Ile Ser Cys 20 < 210 > 26 < 211 > 15 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 26 Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 1 5 10 15 < 210 > 27 < 211 > 32 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 27 Gly Val Pro Ala Arg Phe Ser Gly Ser Gly Ser Gly Thr Ser Tyr Ser 1 5 10 15 Leu Thr Ile Ser Ser Met Glu Ala Glu Asp Ala Ala Thr Tyr Tyr Cys 20 25 30 < 210 > 28 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 28 Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 1 5 10 < 210 > 29 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 29 Arg Asp Asn Tyr Asp Trp Tyr Phe Asp Val 1 5 10 < 210 > 30 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 30 Gly Tyr Ala Ile Thr 1 5 < 210 > 31 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 31 Gly Ile Ser Ser Ala Ala Thr Thr Phe Tyr Ser Ser Trp Ala Lys Ser 1 5 10 15 < 210 > 32 < 211 > 14 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 32 Asp Pro Arg Gly Tyr Gly Ala Ala Leu Asp Arg Leu Asp Leu 1 5 10 < 210 > 33 < 211 > 12 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 33 Gln Ser Ile Lys Ser Val Tyr Asn Asn Arg Leu Gly 1 5 10 < 210 > 34 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 34 Glu Thr Ser Ile Leu Thr Ser 1 5 < 210 > 35 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 35 Ala Gly Gly Phe Asp Arg Ser Gly Asp Thr Thr 1 5 10 < 210 > 36 < 211 > 122 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 36 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Arg Phe Ser Leu Ile Gly Tyr 20 25 30 Ala Ile Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Gly Ile Ser Ser Ala Ala Thr Thr Phe Tyr Ser Ser Trp Ala Lys 50 55 60 Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Pro Arg Gly Tyr Gly Ala Ala Leu Asp Arg Leu Asp Leu Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 < 210 > 37 < 211 > 110 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 37 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ser Ile Lys Ser Val Tyr Asn Asn 20 25 30 Arg Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Glu Thr Ser Ile Leu Thr Ser Gly Val Pro Ser Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 65 70 75 80 Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Asp Arg Ser 85 90 95 Gly Asp Thr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 < 210 > 38 < 211 > 30 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 38 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Arg Phe Ser Leu Ile 20 25 30 < 210 > 39 < 211 > 14 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 220 > < 221 > MOD _ RES < 222 > ( 2 ) < 223 > X is Ile or Val < 400 > 39 Trp Xaa Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 1 5 10 < 210 > 40 < 211 > 32 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 220 > < 221 > MOD _ RES < 222 > ( 2 ) < 223 > X is Val or Ser < 220 > < 221 > MOD _ RES < 222 > ( 6 ) < 223 > X is Arg or Val < 220 > < 221 > MOD _ RES < 222 > ( 13 ) < 223 > X is Val or Phe < 220 > < 221 > MOD _ RES < 222 > ( 29 ) < 223 > X is Tyr or Phe < 400 > 40 Arg Xaa Thr Ile Ser Xaa Asp Thr Ser Lys Asn Gln Xaa Ser Leu Lys 1 5 10 15 Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Xaa Cys Ala Arg 20 25 30 < 210 > 41 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 41 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 1 5 10 < 210 > 42 < 211 > 14 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 42 Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile Gly 1 5 10 < 210 > 43 < 211 > 32 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 43 Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu Lys 1 5 10 15 Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala Arg 20 25 30 < 210 > 44 < 211 > 30 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 44 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Val Ser Arg Phe Ser Leu Ile 20 25 30 < 210 > 45 < 211 > 14 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 45 Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile Gly 1 5 10 < 210 > 46 < 211 > 32 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 46 Arg Ser Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr Leu Gln 1 5 10 15 Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala Arg 20 25 30 < 210 > 47 < 211 > 122 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 47 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Arg Phe Ser Leu Ile Gly Tyr 20 25 30 Ala Ile Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Gly Ile Ser Ser Ala Ala Thr Thr Phe Tyr Ser Ser Trp Ala Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Pro Arg Gly Tyr Gly Ala Ala Leu Asp Arg Leu Asp Leu Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 < 210 > 48 < 211 > 122 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 48 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Arg Phe Ser Leu Ile Gly Tyr 20 25 30 Ala Ile Thr Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Gly Ile Ser Ser Ala Ala Thr Thr Phe Tyr Ser Ser Trp Ala Lys 50 55 60 Ser Arg Ser Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Phe Cys Ala 85 90 95 Arg Asp Pro Arg Gly Tyr Gly Ala Ala Leu Asp Arg Leu Asp Leu Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 < 210 > 49 < 211 > 122 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 49 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Arg Phe Ser Leu Ile Gly Tyr 20 25 30 Ala Ile Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Gly Ile Ser Ser Ala Ala Thr Thr Phe Tyr Ser Ser Trp Ala Lys 50 55 60 Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Val Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Pro Arg Gly Tyr Gly Ala Ala Leu Asp Arg Leu Asp Leu Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 < 210 > 50 < 211 > 122 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 50 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Arg Phe Ser Leu Ile Gly Tyr 20 25 30 Ala Ile Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Gly Ile Ser Ser Ala Ala Thr Thr Phe Tyr Ser Ser Trp Ala Lys 50 55 60 Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Phe Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Pro Arg Gly Tyr Gly Ala Ala Leu Asp Arg Leu Asp Leu Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 < 210 > 51 < 211 > 122 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 51 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Val Ser Arg Phe Ser Leu Ile Gly Tyr 20 25 30 Ala Ile Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Gly Ile Ser Ser Ala Ala Thr Thr Phe Tyr Ser Ser Trp Ala Lys 50 55 60 Ser Arg Ser Thr Ile Ser Arg Asp Thr Ser Lys Asn Thr Val Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Phe Cys Ala 85 90 95 Arg Asp Pro Arg Gly Tyr Gly Ala Ala Leu Asp Arg Leu Asp Leu Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 < 210 > 52 < 211 > 121 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 52 Gln Ser Leu Glu Glu Ser Gly Gly Gly Leu Phe Lys Pro Thr Asp Thr 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Arg Phe Ser Leu Ile Gly Tyr Ala 20 25 30 Ile Thr Trp Val Arg Gln Ser Pro Glu Asn Gly Leu Glu Trp Ile Gly 35 40 45 Gly Ile Ser Ser Ala Ala Thr Thr Phe Tyr Ser Ser Trp Ala Lys Ser 50 55 60 Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 65 70 75 80 Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 85 90 95 Asp Pro Arg Gly Tyr Gly Ala Ala Leu Asp Arg Leu Asp Leu Trp Gly 100 105 110 Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 < 210 > 53 < 211 > 110 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 53 Ala Ala Val Leu Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Ser Ile Ser Cys Gln Ser Ile Lys Ser Val Tyr Asn Asn 20 25 30 Arg Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 35 40 45 Ile Tyr Glu Thr Ser Ile Leu Thr Ser Gly Val Pro Ser Arg Phe Lys 50 55 60 Gly Ser Gly Ser Glu Thr Gln Phe Thr Leu Thr Ile Ser Asp Val Gln 65 70 75 80 Cys Asp Asp Ala Ala Thr Tyr Phe Cys Ala Gly Gly Phe Asp Arg Ser 85 90 95 Gly Asp Thr Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 < 210 > 54 < 211 > 29 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 54 Gln Ser Leu Glu Glu Ser Gly Gly Gly Leu Phe Lys Pro Thr Asp Thr 1 5 10 15 Leu Thr Leu Thr Cys Thr Val Ser Arg Phe Ser Leu Ile 20 25 < 210 > 55 < 211 > 14 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 55 Trp Val Arg Gln Ser Pro Glu Asn Gly Leu Glu Trp Ile Gly 1 5 10 < 210 > 56 < 211 > 32 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 56 Arg Ser Thr Ile Thr Arg Asn Thr Asn Glu Asn Thr Val Thr Leu Lys 1 5 10 15 Met Thr Ser Leu Thr Ala Ala Asp Thr Ala Thr Tyr Phe Cys Ala Arg 20 25 30 < 210 > 57 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 57 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 1 5 10 < 210 > 58 < 211 > 110 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 58 Asp Ala Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ser Ile Lys Ser Val Tyr Asn Asn 20 25 30 Arg Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Pro Pro Lys Leu Leu 35 40 45 Ile Tyr Glu Thr Ser Ile Leu Thr Ser Gly Val Pro Ser Arg Phe Ser 50 55 60 Gly Ser Gly Ser Glu Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 65 70 75 80 Pro Glu Asp Phe Ala Thr Tyr Phe Cys Ala Gly Gly Phe Asp Arg Ser 85 90 95 Gly Asp Thr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 < 210 > 59 < 211 > 110 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 59 Ala Ala Val Leu Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Ser Ile Ser Cys Gln Ser Ile Lys Ser Val Tyr Asn Asn 20 25 30 Arg Leu Gly Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu 35 40 45 Ile Tyr Glu Thr Ser Ile Leu Thr Ser Gly Val Pro Ser Arg Phe Lys 50 55 60 Gly Ser Gly Ser Glu Thr Gln Phe Thr Leu Thr Ile Ser Asp Val Gln 65 70 75 80 Ala Asp Asp Ala Ala Thr Tyr Phe Cys Ala Gly Gly Phe Asp Arg Ser 85 90 95 Gly Asp Thr Thr Phe Gly Gly Gly Thr Glu Val Val Val Lys 100 105 110 < 210 > 60 < 211 > 23 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 220 > < 221 > MOD _ RES < 222 > ( 2 ) < 223 > X is Ile or Ala < 220 > < 221 > MOD _ RES < 222 > ( 4 ) < 223 > X is Met or Leu < 400 > 60 Asp Xaa Gln Xaa Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys 20 < 210 > 61 < 211 > 15 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 220 > < 221 > MOD _ RES < 222 > ( 9 ) < 223 > X is Ala or Pro < 400 > 61 Trp Tyr Gln Gln Lys Pro Gly Lys Xaa Pro Lys Leu Leu Ile Tyr 1 5 10 15 < 210 > 62 < 211 > 32 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 220 > < 221 > MOD _ RES < 222 > ( 12 ) < 223 > X is Gly or Glu < 220 > < 221 > MOD _ RES < 222 > ( 31 ) < 223 > X is Tyr or Phe < 400 > 62 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Xaa Thr Asp Phe Thr 1 5 10 15 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Xaa Cys 20 25 30 < 210 > 63 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 63 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 1 5 10 < 210 > 64 < 211 > 23 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 64 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys 20 < 210 > 65 < 211 > 15 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 65 Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 1 5 10 15 < 210 > 66 < 211 > 32 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 66 Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 1 5 10 15 Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys 20 25 30 < 210 > 67 < 211 > 23 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 67 Ala Ala Val Leu Thr Gln Thr Pro Ala Ser Val Ser Ala Ala Val Gly 1 5 10 15 Gly Thr Val Ser Ile Ser Cys 20 < 210 > 68 < 211 > 15 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 68 Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile Tyr 1 5 10 15 < 210 > 69 < 211 > 32 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 220 > < 221 > MOD _ RES < 222 > ( 24 ) < 223 > X is Cys or Ala < 400 > 69 Gly Val Pro Ser Arg Phe Lys Gly Ser Gly Ser Glu Thr Gln Phe Thr 1 5 10 15 Leu Thr Ile Ser Asp Val Gln Xaa Asp Asp Ala Ala Thr Tyr Phe Cys 20 25 30 < 210 > 70 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 70 Phe Gly Gly Gly Thr Glu Val Val Val Lys 1 5 10 < 210 > 71 < 211 > 275 < 212 > PRT < 213 > Homo sapiens < 400 > 71 Met Leu Asn Leu Leu Leu Leu Ala Leu Pro Val Leu Ala Ser Arg Ala 1 5 10 15 Tyr Ala Ala Pro Ala Pro Gly Gln Ala Leu Gln Arg Val Gly Ile Val 20 25 30 Gly Gly Gln Glu Ala Pro Arg Ser Lys Trp Pro Trp Gln Val Ser Leu 35 40 45 Arg Val His Gly Pro Tyr Trp Met His Phe Cys Gly Gly Ser Leu Ile 50 55 60 His Pro Gln Trp Val Leu Thr Ala Ala His Cys Val Gly Pro Asp Val 65 70 75 80 Lys Asp Leu Ala Ala Leu Arg Val Gln Leu Arg Glu Gln His Leu Tyr 85 90 95 Tyr Gln Asp Gln Leu Leu Pro Val Ser Arg Ile Ile Val His Pro Gln 100 105 110 Phe Tyr Thr Ala Gln Ile Gly Ala Asp Ile Ala Leu Leu Glu Leu Glu 115 120 125 Glu Pro Val Asn Val Ser Ser His Val His Thr Val Thr Leu Pro Pro 130 135 140 Ala Ser Glu Thr Phe Pro Pro Gly Met Pro Cys Trp Val Thr Gly Trp 145 150 155 160 Gly Asp Val Asp Asn Asp Glu Arg Leu Pro Pro Pro Phe Pro Leu Lys 165 170 175 Gln Val Lys Val Pro Ile Met Glu Asn His Ile Cys Asp Ala Lys Tyr 180 185 190 His Leu Gly Ala Tyr Thr Gly Asp Asp Val Arg Ile Val Arg Asp Asp 195 200 205 Met Leu Cys Ala Gly Asn Thr Arg Arg Asp Ser Cys Gln Gly Asp Ser 210 215 220 Gly Gly Pro Leu Val Cys Lys Val Asn Gly Thr Trp Leu Gln Ala Gly 225 230 235 240 Val Val Ser Trp Gly Glu Gly Cys Ala Gln Pro Asn Arg Pro Gly Ile 245 250 255 Tyr Thr Arg Val Thr Tyr Tyr Leu Asp Trp Ile His His Tyr Val Pro 260 265 270 Lys Lys Pro 275 < 210 > 72 < 211 > 275 < 212 > PRT < 213 > Homo sapiens < 400 > 72 Met Leu Asn Leu Leu Leu Leu Ala Leu Pro Val Leu Ala Ser Arg Ala 1 5 10 15 Tyr Ala Ala Pro Ala Pro Gly Gln Ala Leu Gln Arg Val Gly Ile Val 20 25 30 Gly Gly Gln Glu Ala Pro Arg Ser Lys Trp Pro Trp Gln Val Ser Leu 35 40 45 Arg Val His Gly Pro Tyr Trp Met His Phe Cys Gly Gly Ser Leu Ile 50 55 60 His Pro Gln Trp Val Leu Thr Ala Ala His Cys Val Gly Pro Asp Val 65 70 75 80 Lys Asp Leu Ala Ala Leu Arg Val Gln Leu Arg Glu Gln His Leu Tyr 85 90 95 Tyr Gln Asp Gln Leu Leu Pro Val Ser Arg Ile Ile Val His Pro Gln 100 105 110 Phe Tyr Thr Ala Gln Ile Gly Ala Asp Ile Ala Leu Leu Glu Leu Glu 115 120 125 Glu Pro Val Lys Val Ser Ser His Val His Thr Val Thr Leu Pro Pro 130 135 140 Ala Ser Glu Thr Phe Pro Pro Gly Met Pro Cys Trp Val Thr Gly Trp 145 150 155 160 Gly Asp Val Asp Asn Asp Glu Arg Leu Pro Pro Pro Phe Pro Leu Lys 165 170 175 Gln Val Lys Val Pro Ile Met Glu Asn His Ile Cys Asp Ala Lys Tyr 180 185 190 His Leu Gly Ala Tyr Thr Gly Asp Asp Val Arg Ile Val Arg Asp Asp 195 200 205 Met Leu Cys Ala Gly Asn Thr Arg Arg Asp Ser Cys Gln Gly Asp Ser 210 215 220 Gly Gly Pro Leu Val Cys Lys Val Asn Gly Thr Trp Leu Gln Ala Gly 225 230 235 240 Val Val Ser Trp Gly Glu Gly Cys Ala Gln Pro Asn Arg Pro Gly Ile 245 250 255 Tyr Thr Arg Val Thr Tyr Tyr Leu Asp Trp Ile His His Tyr Val Pro 260 265 270 Lys Lys Pro 275 < 210 > 73 < 211 > 233 < 212 > PRT < 213 > Homo sapiens < 400 > 73 Met Leu Asn Leu Leu Leu Leu Ala Leu Pro Val Leu Ala Ser Arg Ala 1 5 10 15 Tyr Ala Ala Pro Ala Pro Gly Gln Ala Leu Gln Arg Val Gly Ile Val 20 25 30 Gly Gly Gln Glu Ala Pro Arg Ser Lys Trp Pro Trp Gln Val Ser Leu 35 40 45 Arg Val Arg Asp Arg Tyr Trp Met His Phe Cys Gly Gly Ser Leu Ile 50 55 60 His Pro Gln Trp Val Leu Thr Ala Ala His Cys Val Gly Pro Asp Val 65 70 75 80 Lys Asp Leu Ala Ala Leu Arg Val Gln Leu Arg Glu Gln His Leu Tyr 85 90 95 Tyr Gln Asp Gln Leu Leu Pro Val Ser Arg Ile Ile Val His Pro Gln 100 105 110 Phe Tyr Thr Ala Gln Ile Gly Ala Asp Ile Ala Leu Leu Glu Leu Glu 115 120 125 Glu Pro Val Asn Val Ser Ser His Val His Thr Val Thr Leu Pro Pro 130 135 140 Ala Ser Glu Thr Phe Pro Pro Gly Met Pro Cys Trp Val Thr Gly Trp 145 150 155 160 Gly Asp Val Asp Asn Asp Glu Arg Leu Pro Pro Pro Phe Pro Leu Lys 165 170 175 Gln Val Lys Val Pro Ile Met Glu Asn His Ile Cys Asp Ala Lys Tyr 180 185 190 His Leu Gly Ala Tyr Thr Gly Asp Asp Val Arg Ile Val Arg Asp Asp 195 200 205 Met Leu Cys Ala Gly Asn Thr Arg Arg Asp Ser Cys Gln Val Ala Thr 210 215 220 Ala Pro His Thr Phe Pro Ala Pro Ser 225 230 < 210 > 74 < 211 > 21 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 74 gatggtgact gttccagttg c 21 < 210 > 75 < 211 > 23 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 75 cattggtgag ggtgcccgag ttc 23 < 210 > 76 < 211 > 448 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 76 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Phe Ile Ser Ser Gly Ser Ser Thr Val Tyr Tyr Ala Asp Thr Met 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Arg Asn Tyr Asp Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 115 120 125 Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 130 135 140 Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 145 150 155 160 Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 165 170 175 Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 180 185 190 Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 195 200 205 Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser Cys Asp Lys 210 215 220 Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 225 230 235 240 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 245 250 255 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 260 265 270 Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 275 280 285 Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 290 295 300 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 305 310 315 320 Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 325 330 335 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 340 345 350 Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 355 360 365 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 370 375 380 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 385 390 395 400 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 405 410 415 Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 420 425 430 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 445 < 210 > 77 < 211 > 213 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 77 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 20 25 30 Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Pro Trp Ile Tyr 35 40 45 Arg Thr Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 65 70 75 80 Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr His Ser Tyr Pro Leu Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 100 105 110 Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 115 120 125 Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 130 135 140 Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 145 150 155 160 Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 165 170 175 Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 180 185 190 Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 195 200 205 Asn Arg Gly Glu Cys 210 < 210 > 78 < 211 > 445 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 78 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Phe Ile Ser Ser Gly Ser Ser Thr Val Tyr Tyr Ala Asp Thr Met 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Arg Asn Tyr Asp Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 115 120 125 Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 130 135 140 Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 145 150 155 160 Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 165 170 175 Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 180 185 190 Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 195 200 205 Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 210 215 220 Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 225 230 235 240 Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 245 250 255 Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 260 265 270 Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 275 280 285 Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 290 295 300 Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 305 310 315 320 Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 325 330 335 Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 340 345 350 Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 355 360 365 Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 370 375 380 Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 385 390 395 400 Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 405 410 415 Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 420 425 430 Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 435 440 445 < 210 > 79 < 211 > 213 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 79 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 20 25 30 Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Pro Trp Ile Tyr 35 40 45 Arg Thr Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 65 70 75 80 Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr His Ser Tyr Pro Leu Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 100 105 110 Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 115 120 125 Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 130 135 140 Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 145 150 155 160 Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 165 170 175 Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 180 185 190 Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 195 200 205 Asn Arg Gly Glu Cys 210 < 210 > 80 < 211 > 451 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 80 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Arg Phe Ser Leu Ile Gly Tyr 20 25 30 Ala Ile Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Gly Ile Ser Ser Ala Ala Thr Thr Phe Tyr Ser Ser Trp Ala Lys 50 55 60 Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Pro Arg Gly Tyr Gly Ala Ala Leu Asp Arg Leu Asp Leu Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 115 120 125 Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 130 135 140 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 145 150 155 160 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 165 170 175 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 180 185 190 Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 195 200 205 His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 210 215 220 Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 225 230 235 240 Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 245 250 255 Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 260 265 270 His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 275 280 285 Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 290 295 300 Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 305 310 315 320 Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 325 330 335 Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 340 345 350 Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val 355 360 365 Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 370 375 380 Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 385 390 395 400 Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 405 410 415 Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 420 425 430 Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 435 440 445 Ser Pro Gly 450 < 210 > 81 < 211 > 217 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 81 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ser Ile Lys Ser Val Tyr Asn Asn 20 25 30 Arg Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Glu Thr Ser Ile Leu Thr Ser Gly Val Pro Ser Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 65 70 75 80 Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Asp Arg Ser 85 90 95 Gly Asp Thr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 100 105 110 Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 115 120 125 Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 130 135 140 Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 145 150 155 160 Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 165 170 175 Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 180 185 190 Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 195 200 205 Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 < 210 > 82 < 211 > 448 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 82 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Arg Phe Ser Leu Ile Gly Tyr 20 25 30 Ala Ile Thr Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Ile 35 40 45 Gly Gly Ile Ser Ser Ala Ala Thr Thr Phe Tyr Ser Ser Trp Ala Lys 50 55 60 Ser Arg Val Thr Ile Ser Arg Asp Thr Ser Lys Asn Gln Val Ser Leu 65 70 75 80 Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Asp Pro Arg Gly Tyr Gly Ala Ala Leu Asp Arg Leu Asp Leu Trp 100 105 110 Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 115 120 125 Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 130 135 140 Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 145 150 155 160 Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 165 170 175 Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 180 185 190 Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp 195 200 205 His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr 210 215 220 Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro 225 230 235 240 Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 245 250 255 Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp 260 265 270 Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 275 280 285 Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val 290 295 300 Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 305 310 315 320 Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys 325 330 335 Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 340 345 350 Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 355 360 365 Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 370 375 380 Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 385 390 395 400 Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys 405 410 415 Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu 420 425 430 Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly 435 440 445 < 210 > 83 < 211 > 217 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 83 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Gln Ser Ile Lys Ser Val Tyr Asn Asn 20 25 30 Arg Leu Gly Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Glu Thr Ser Ile Leu Thr Ser Gly Val Pro Ser Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln 65 70 75 80 Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Ala Gly Gly Phe Asp Arg Ser 85 90 95 Gly Asp Thr Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg Thr 100 105 110 Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu 115 120 125 Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro 130 135 140 Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly 145 150 155 160 Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr 165 170 175 Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His 180 185 190 Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val 195 200 205 Thr Lys Ser Phe Asn Arg Gly Glu Cys 210 215 < 210 > 84 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 84 Ala Tyr Ser Val Asn 1 5 < 210 > 85 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 85 Met Ile Trp Gly Asp Gly Lys Ile Val Tyr Asn Ser Ala Leu Lys Ser 1 5 10 15 < 210 > 86 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 86 Asp Gly Tyr Tyr Pro Tyr Ala Met Asp Asn 1 5 10 < 210 > 87 < 211 > 15 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 87 Arg Ala Ser Lys Ser Val Asp Ser Tyr Gly Asn Ser Phe Met His 1 5 10 15 < 210 > 88 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 88 Leu Ala Ser Asn Leu Glu Ser 1 5 < 210 > 89 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 89 Gln Gln Asn Asn Glu Asp Pro Arg Thr 1 5 < 210 > 90 < 211 > 118 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 90 Gln Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ala Tyr 20 25 30 Ser Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 35 40 45 Ala Met Ile Trp Gly Asp Gly Lys Ile Val Tyr Asn Ser Ala Leu Lys 50 55 60 Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu 65 70 75 80 Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala 85 90 95 Gly Asp Gly Tyr Tyr Pro Tyr Ala Met Asp Asn Trp Gly Gln Gly Ser 100 105 110 Leu Val Thr Val Ser Ser 115 < 210 > 91 < 211 > 111 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 91 Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ser Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Asp Ser Tyr 20 25 30 Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Asn Asn 85 90 95 Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 < 210 > 92 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 92 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Tyr Ser Tyr Pro Phe 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 93 < 211 > 113 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthethic Construct < 400 > 93 Glu Val Gln Leu Val Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Ile Ser Ser Gly 20 25 30 Gly Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Phe Asp Tyr Trp Gly Gln Phe Thr Leu Val Thr Val Ser 100 105 110 Ser < 210 > 94 < 211 > 112 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 94 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Ala Ile Ser Ser Ser Gly Ser Ser Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 100 105 110 < 210 > 95 < 211 > 36 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 95 Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 1 5 10 15 Cys Gln Gln Tyr Tyr Ser Tyr Pro Phe Thr Phe Gly Gln Gly Thr Lys 20 25 30 Val Glu Ile Lys 35 < 210 > 96 < 211 > 38 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 96 Thr Leu Thr Ile Ser Asp Val Gln Cys Asp Asp Ala Ala Thr Tyr Phe 1 5 10 15 Cys Ala Gly Gly Phe Asp Arg Ser Gly Asp Thr Thr Phe Gly Gly Gly 20 25 30 Thr Glu Val Val Val Lys 35 < 210 > 97 < 211 > 245 < 212 > PRT < 213 > Homo sapiens < 400 > 97 Ile Val Gly Gly Gln Glu Ala Pro Arg Ser Lys Trp Pro Trp Gln Val 1 5 10 15 Ser Leu Arg Val His Gly Pro Tyr Trp Met His Phe Cys Gly Gly Ser 20 25 30 Leu Ile His Pro Gln Trp Val Leu Thr Ala Ala His Cys Val Gly Pro 35 40 45 Asp Val Lys Asp Leu Ala Ala Leu Arg Val Gln Leu Arg Glu Gln His 50 55 60 Leu Tyr Tyr Gln Asp Gln Leu Leu Pro Val Ser Arg Ile Ile Val His 65 70 75 80 Pro Gln Phe Tyr Thr Ala Gln Ile Gly Ala Asp Ile Ala Leu Leu Glu 85 90 95 Leu Glu Glu Pro Val Asn Val Ser Ser His Val His Thr Val Thr Leu 100 105 110 Pro Pro Ala Ser Glu Thr Phe Pro Pro Gly Met Pro Cys Trp Val Thr 115 120 125 Gly Trp Gly Asp Val Asp Asn Asp Glu Arg Leu Pro Pro Pro Phe Pro 130 135 140 Leu Lys Gln Val Lys Val Pro Ile Met Glu Asn His Ile Cys Asp Ala 145 150 155 160 Lys Tyr His Leu Gly Ala Tyr Thr Gly Asp Asp Val Arg Ile Val Arg 165 170 175 Asp Asp Met Leu Cys Ala Gly Asn Thr Arg Arg Asp Ser Cys Gln Gly 180 185 190 Asp Ser Gly Gly Pro Leu Val Cys Lys Val Asn Gly Thr Trp Leu Gln 195 200 205 Ala Gly Val Val Ser Trp Gly Glu Gly Cys Ala Gln Pro Asn Arg Pro 210 215 220 Gly Ile Tyr Thr Arg Val Thr Tyr Tyr Leu Asp Trp Ile His His Tyr 225 230 235 240 Val Pro Lys Lys Pro 245 < 210 > 98 < 211 > 119 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 98 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Phe Ile Ser Ser Gly Ser Ser Thr Val Tyr Tyr Ala Asp Thr Met 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Val Tyr Cys 85 90 95 Ala Arg Arg Asp Asn Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 < 210 > 99 < 211 > 119 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 99 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Phe Ile Ser Ser Gly Ser Ser Thr Val Tyr Tyr Ala Asp Thr Met 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Val Tyr Cys 85 90 95 Ala Arg Arg Asp Asn Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 < 210 > 100 < 211 > 119 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 100 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Gly Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Phe Ile Ser Ser Gly Ser Ser Thr Val Tyr Tyr Ala Asp Thr Met 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Val Tyr Cys 85 90 95 Ala Arg Arg Asp Asn Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 < 210 > 101 < 211 > 119 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 101 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 20 25 30 Gly Met Val Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Phe Ile Ser Ser Gly Ser Ser Thr Val Tyr Tyr Ala Asp Thr Met 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Val Tyr Cys 85 90 95 Thr Arg Arg Asp Asn Tyr Asp Trp Tyr Phe Asp Val Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 < 210 > 102 < 211 > 106 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 102 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 20 25 30 Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr 35 40 45 Arg Thr Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 65 70 75 80 Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr His Ser Tyr Pro Leu Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 103 < 211 > 106 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 103 Asp Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Ser Ala Ser Ser Ser Val Thr Tyr Met 20 25 30 Tyr Trp Tyr Gln Gln Lys Pro Gly Lys Ser Pro Lys Pro Trp Ile Tyr 35 40 45 Arg Thr Ser Asp Leu Ala Ser Gly Val Pro Ser Arg Phe Ser Gly Ser 50 55 60 Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu 65 70 75 80 Asp Phe Ala Thr Tyr Tyr Cys Gln His Tyr His Ser Tyr Pro Leu Thr 85 90 95 Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 104 < 211 > 357 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 104 gaagtgcagc tggtggaaag cggcggcggc ctggtgcagc caggcggcag cctgcgcctg 60 agctgcgccg ccagcggctt caccttcagc gattatggca tggtgtgggt gcgccaggcc 120 ccaggcaaag gcctggaatg ggtggccttc atcagcagcg gcagcagcac cgtgtattat 180 gccgatacca tgaaaggccg cttcaccatc agccgcgata acagcaaaaa caccctgtat 240 ctgcagatga acagcctgcg cgccgaagat accgccgtgt attattgcac ccgccgcaac 300 tacgatgatt ggtatttcga tgtgtggggc cagggcaccc tggtgaccgt ctcgagt 357 < 210 > 105 < 211 > 318 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 105 gatatccaga tgacccagag cccaagcagc ctgagcgcca gcgtgggcga tcgcgtgacc 60 atcacctgca gcgccagcag cagcgtgacc tatatgtatt ggtatcagca gaaaccaggc 120 aaaagcccaa aaccatggat ctatcgcacc agcgatctgg ccagcggcgt gccaagccgc 180 ttcagcggca gcggcagcgg caccgatttc accctgacca tcagcagcct gcagccagaa 240 gatttcgcca cctattattg ccagcactat cacagctatc cactgacctt cggccagggt 300 accaaggtgg agatcaaa 318 < 210 > 106 < 211 > 1347 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 106 gaagtgcagc tggtggaaag cggcggcggc ctggtgcagc caggcggcag cctgcgcctg 60 agctgcgccg ccagcggctt caccttcagc gattatggca tggtgtgggt gcgccaggcc 120 ccaggcaaag gcctggaatg ggtggccttc atcagcagcg gcagcagcac cgtgtattat 180 gccgatacca tgaaaggccg cttcaccatc agccgcgata acagcaaaaa caccctgtat 240 ctgcagatga acagcctgcg cgccgaagat accgccgtgt attattgcac ccgccgcaac 300 tacgatgatt ggtatttcga tgtgtggggc cagggcaccc tggtgaccgt ctcgagtgcc 360 tccaccaagg gcccatcggt cttccccctg gcaccctcct ccaagagcac ctctgggggc 420 acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480 aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540 ctctactccc tcagcagcgt ggtgactgtg ccctctagca gcttgggcac ccagacctac 600 atctgcaacg tgaatcacaa gcccagcaac accaaggtgg acaagaaagt tgagcccaaa 660 tcttgtgaca aaactcacac atgcccaccg tgcccagcac ctgaactcct ggggggaccg 720 tcagtcttcc tcttcccccc aaaacccaag gacaccctca tgatctcccg gacccctgag 780 gtcacatgcg tggtggtgga cgtgagccac gaagaccctg aggtcaagtt caactggtac 840 gtggacggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gtacaacagc 900 acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa tggcaaggag 960 tacaagtgca aggtctccaa caaagccctc ccagccccca tcgagaaaac catctccaaa 1020 gccaaagggc agccccgaga accacaggtg tacaccctgc ccccatcccg ggaagagatg 1080 accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctatcccag cgacatcgcc 1140 gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200 gactccgacg gctccttctt cctctacagc aagctcaccg tggacaagag caggtggcag 1260 caggggaacg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacgcag 1320 aagagcctct ccctgtctcc gggtaaa 1347 < 210 > 107 < 211 > 639 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 107 gatatccaga tgacccagag cccaagcagc ctgagcgcca gcgtgggcga tcgcgtgacc 60 atcacctgca gcgccagcag cagcgtgacc tatatgtatt ggtatcagca gaaaccaggc 120 aaaagcccaa aaccatggat ctatcgcacc agcgatctgg ccagcggcgt gccaagccgc 180 ttcagcggca gcggcagcgg caccgatttc accctgacca tcagcagcct gcagccagaa 240 gatttcgcca cctattattg ccagcactat cacagctatc cactgacctt cggccagggt 300 accaaggtgg agatcaaacg aactgtggct gcaccatctg tcttcatctt cccgccatct 360 gatgagcagt tgaaatctgg aactgcttct gttgtgtgcc tgctgaataa cttctatccc 420 agagaggcca aagtacagtg gaaggtggat aacgccctcc aatcgggtaa ctcccaggag 480 agtgtcacag agcaggacag caaggacagc acctacagcc tcagcagcac cctgacgctg 540 agcaaagcag actacgagaa acacaaagtc tacgcctgcg aagtcaccca tcagggcctg 600 agctcgcccg tcacaaagag cttcaacagg ggagagtgt 639 < 210 > 108 < 211 > 1338 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 108 gaagtgcagc tggtggaaag cggcggcggc ctggtgcagc caggcggcag cctgcgcctg 60 agctgcgccg ccagcggctt caccttcagc gattatggca tggtgtgggt gcgccaggcc 120 ccaggcaaag gcctggaatg ggtggccttc atcagcagcg gcagcagcac cgtgtattat 180 gccgatacca tgaaaggccg cttcaccatc agccgcgata acagcaaaaa caccctgtat 240 ctgcagatga acagcctgcg cgccgaagat accgccgtgt attattgcac ccgccgcaac 300 tacgatgatt ggtatttcga tgtgtggggc cagggcaccc tggtgaccgt ctcgagtgcc 360 tccaccaagg gcccatcggt cttccccctg gcaccctgct cccgcagtac ttctgagtcc 420 acagcggccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg 480 aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga 540 ctctactccc tcagcagcgt ggtgactgtg ccctctagca gcttgggcac caagacctac 600 acgtgcaacg tggatcacaa gcccagcaac accaaggtgg acaaacgcgt tgagtccaaa 660 tatggtcccc catgcccacc atgcccagca cctgagttcc tggggggacc atcagtcttc 720 ctgttccccc caaaacccaa ggacactctc atgatctccc ggacccctga ggtcacgtgc 780 gtggtggtgg acgtgagcca ggaagacccc gaggtccagt tcaactggta cgtggatggc 840 gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agttcaacag cacgtaccgt 900 gtggtcagcg tcctcaccgt cctgcaccag gactggctga acggcaagga gtacaagtgc 960 aaggtctcca acaaaggcct cccgtcctcc atcgagaaaa ccatctccaa agccaaaggg 1020 cagccccgag agccacaggt gtacaccctg cccccatccc aggaggagat gaccaagaac 1080 caggtcagcc tgacctgcct ggtcaaaggc ttctacccca gcgacatcgc cgtggagtgg 1140 gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac 1200 ggctccttct tcctctacag caggctaacc gtggacaaga gcaggtggca ggaggggaat 1260 gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacaca gaagagcctc 1320 tccctgtctc tgggtaaa 1338 < 210 > 109 < 211 > 366 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 109 gaagtgcagc tggtggaaag cggcccaggc ctggtgaaac caagcgaaac cctgagcctg 60 acctgcaccg tgagccgctt cagcctgatc ggctatgcca tcacctggat ccgccagcca 120 ccaggcaaag gcctggaatg gatcggcggc atcagcagcg ccgccaccac cttctatagc 180 agctgggcca aaagccgcgt gaccatcagc cgcgatacca gcaaaaacca ggtgagcctg 240 aaactgagca gcgtgaccgc cgccgatacc gccgtgtatt attgcgcccg cgatccacgc 300 ggctatggcg ccgccctgga tcgcctggat ctgtggggcc agggcaccct ggtgaccgtc 360 tcgagt 366 < 210 > 110 < 211 > 330 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 110 gatatccaga tgacccagag cccaagcagc ctgagcgcca gcgtgggcga tcgcgtgacc 60 atcacctgcc agagcatcaa aagcgtgtat aacaaccgcc tgggctggta tcagcagaaa 120 ccaggcaaag ccccaaaact gctgatctat gaaaccagca tcctgaccag cggcgtgcca 180 agccgcttca gcggcagcgg cagcggcacc gatttcaccc tgaccatcag cagcctgcag 240 ccagaagatt tcgccaccta ttattgcgcc ggcggcttcg atcgcagcgg cgataccacc 300 ttcggccagg gtaccaaggt ggagatcaaa 330 < 210 > 111 < 211 > 1356 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 111 gaagtgcagc tggtggaaag cggcccaggc ctggtgaaac caagcgaaac cctgagcctg 60 acctgcaccg tgagccgctt cagcctgatc ggctatgcca tcacctggat ccgccagcca 120 ccaggcaaag gcctggaatg gatcggcggc atcagcagcg ccgccaccac cttctatagc 180 agctgggcca aaagccgcgt gaccatcagc cgcgatacca gcaaaaacca ggtgagcctg 240 aaactgagca gcgtgaccgc cgccgatacc gccgtgtatt attgcgcccg cgatccacgc 300 ggctatggcg ccgccctgga tcgcctggat ctgtggggcc agggcaccct ggtgaccgtc 360 tcgagtgcct ccaccaaggg cccatcggtc ttccccctgg caccctcctc caagagcacc 420 tctgggggca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg 480 gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag 540 tcctcaggac tctactccct cagcagcgtg gtgactgtgc cctctagcag cttgggcacc 600 cagacctaca tctgcaacgt gaatcacaag cccagcaaca ccaaggtgga caagaaagtt 660 gagcccaaat cttgtgacaa aactcacaca tgcccaccgt gcccagcacc tgaactcctg 720 gggggaccgt cagtcttcct cttcccccca aaacccaagg acaccctcat gatctcccgg 780 acccctgagg tcacatgcgt ggtggtggac gtgagccacg aagaccctga ggtcaagttc 840 aactggtacg tggacggcgt ggaggtgcat aatgccaaga caaagccgcg ggaggagcag 900 tacaacagca cgtaccgtgt ggtcagcgtc ctcaccgtcc tgcaccagga ctggctgaat 960 ggcaaggagt acaagtgcaa ggtctccaac aaagccctcc cagcccccat cgagaaaacc 1020 atctccaaag ccaaagggca gccccgagaa ccacaggtgt acaccctgcc cccatcccgg 1080 gaagagatga ccaagaacca ggtcagcctg acctgcctgg tcaaaggctt ctatcccagc 1140 gacatcgccg tggagtggga gagcaatggg cagccggaga acaactacaa gaccacgcct 1200 cccgtgctgg actccgacgg ctccttcttc ctctacagca agctcaccgt ggacaagagc 1260 aggtggcagc aggggaacgt cttctcatgc tccgtgatgc atgaggctct gcacaaccac 1320 tacacgcaga agagcctctc cctgtctccg ggtaaa 1356 < 210 > 112 < 211 > 651 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 112 gatatccaga tgacccagag cccaagcagc ctgagcgcca gcgtgggcga tcgcgtgacc 60 atcacctgcc agagcatcaa aagcgtgtat aacaaccgcc tgggctggta tcagcagaaa 120 ccaggcaaag ccccaaaact gctgatctat gaaaccagca tcctgaccag cggcgtgcca 180 agccgcttca gcggcagcgg cagcggcacc gatttcaccc tgaccatcag cagcctgcag 240 ccagaagatt tcgccaccta ttattgcgcc ggcggcttcg atcgcagcgg cgataccacc 300 ttcggccagg gtaccaaggt ggagatcaaa cgaactgtgg ctgcaccatc tgtcttcatc 360 ttcccgccat ctgatgagca gttgaaatct ggaactgctt ctgttgtgtg cctgctgaat 420 aacttctatc ccagagaggc caaagtacag tggaaggtgg ataacgccct ccaatcgggt 480 aactcccagg agagtgtcac agagcaggac agcaaggaca gcacctacag cctcagcagc 540 accctgacgc tgagcaaagc agactacgag aaacacaaag tctacgcctg cgaagtcacc 600 catcagggcc tgagctcgcc cgtcacaaag agcttcaaca ggggagagtg t 651 < 210 > 113 < 211 > 1347 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 113 gaagtgcagc tggtggaaag cggcccaggc ctggtgaaac caagcgaaac cctgagcctg 60 acctgcaccg tgagccgctt cagcctgatc ggctatgcca tcacctggat ccgccagcca 120 ccaggcaaag gcctggaatg gatcggcggc atcagcagcg ccgccaccac cttctatagc 180 agctgggcca aaagccgcgt gaccatcagc cgcgatacca gcaaaaacca ggtgagcctg 240 aaactgagca gcgtgaccgc cgccgatacc gccgtgtatt attgcgcccg cgatccacgc 300 ggctatggcg ccgccctgga tcgcctggat ctgtggggcc agggcaccct ggtgaccgtc 360 tcgagtgcct ccaccaaggg cccatcggtc ttccccctgg caccctgctc ccgcagtact 420 tctgagtcca cagcggccct gggctgcctg gtcaaggact acttccccga accggtgacg 480 gtgtcgtgga actcaggcgc cctgaccagc ggcgtgcaca ccttcccggc tgtcctacag 540 tcctcaggac tctactccct cagcagcgtg gtgactgtgc cctctagcag cttgggcacc 600 aagacctaca cgtgcaacgt ggatcacaag cccagcaaca ccaaggtgga caaacgcgtt 660 gagtccaaat atggtccccc atgcccacca tgcccagcac ctgagttcct ggggggacca 720 tcagtcttcc tgttcccccc aaaacccaag gacactctca tgatctcccg gacccctgag 780 gtcacgtgcg tggtggtgga cgtgagccag gaagaccccg aggtccagtt caactggtac 840 gtggatggcg tggaggtgca taatgccaag acaaagccgc gggaggagca gttcaacagc 900 acgtaccgtg tggtcagcgt cctcaccgtc ctgcaccagg actggctgaa cggcaaggag 960 tacaagtgca aggtctccaa caaaggcctc ccgtcctcca tcgagaaaac catctccaaa 1020 gccaaagggc agccccgaga gccacaggtg tacaccctgc ccccatccca ggaggagatg 1080 accaagaacc aggtcagcct gacctgcctg gtcaaaggct tctaccccag cgacatcgcc 1140 gtggagtggg agagcaatgg gcagccggag aacaactaca agaccacgcc tcccgtgctg 1200 gactccgacg gctccttctt cctctacagc aggctaaccg tggacaagag caggtggcag 1260 gaggggaatg tcttctcatg ctccgtgatg catgaggctc tgcacaacca ctacacacag 1320 aagagcctct ccctgtctct gggtaaa 1347 < 210 > 114 < 211 > 118 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 114 Glu Val Thr Leu Arg Glu Ser Gly Pro Ala Leu Val Lys Pro Thr Gln 1 5 10 15 Thr Leu Thr Leu Thr Cys Thr Val Ser Gly Phe Ser Leu Ser Ala Tyr 20 25 30 Ser Val Asn Trp Ile Arg Gln Pro Pro Gly Lys Ala Leu Glu Trp Leu 35 40 45 Ala Met Ile Trp Gly Asp Gly Lys Ile Val Tyr Asn Ser Ala Leu Lys 50 55 60 Ser Arg Leu Thr Ile Ser Lys Asp Thr Ser Lys Asn Gln Val Val Leu 65 70 75 80 Thr Met Thr Asn Met Asp Pro Val Asp Thr Ala Thr Tyr Tyr Cys Ala 85 90 95 Gly Asp Gly Tyr Tyr Pro Tyr Ala Met Asp Asn Trp Gly Gln Gly Ser 100 105 110 Leu Val Thr Val Ser Ser 115 < 210 > 115 < 211 > 111 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 115 Asp Ile Val Leu Thr Gln Ser Pro Asp Ser Leu Ser Val Ser Leu Gly 1 5 10 15 Glu Arg Ala Thr Ile Asn Cys Arg Ala Ser Lys Ser Val Asp Ser Tyr 20 25 30 Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 35 40 45 Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Asp 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Leu Gln Ala Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln Asn Asn 85 90 95 Glu Asp Pro Arg Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 < 210 > 116 < 211 > 256 < 212 > PRT < 213 > Homo sapiens < 400 > 116 Ile Val Gly Gly Gln Glu Ala Pro Arg Ser Lys Trp Pro Trp Gln Val 1 5 10 15 Ser Leu Arg Val His Gly Pro Tyr Trp Met His Phe Cys Gly Gly Ser 20 25 30 Leu Ile His Pro Gln Trp Val Leu Thr Ala Ala His Cys Val Gly Pro 35 40 45 Asp Val Lys Asp Leu Ala Ala Leu Arg Val Gln Leu Arg Glu Gln His 50 55 60 Leu Tyr Tyr Gln Asp Gln Leu Leu Pro Val Ser Arg Ile Ile Val His 65 70 75 80 Pro Gln Phe Tyr Thr Ala Gln Ile Gly Ala Asp Ile Ala Leu Leu Glu 85 90 95 Leu Glu Glu Pro Val Lys Val Ser Ser His Val His Thr Val Thr Leu 100 105 110 Pro Pro Ala Ser Glu Thr Phe Pro Pro Gly Met Pro Cys Trp Val Thr 115 120 125 Gly Trp Gly Asp Val Asp Asn Asp Glu Arg Leu Pro Pro Pro Phe Pro 130 135 140 Leu Lys Gln Val Lys Val Pro Ile Met Glu Asn His Ile Cys Asp Ala 145 150 155 160 Lys Tyr His Leu Gly Ala Tyr Thr Gly Asp Asp Val Arg Ile Val Arg 165 170 175 Asp Asp Met Leu Cys Ala Gly Asn Thr Arg Arg Asp Ser Cys Gln Gly 180 185 190 Asp Ser Gly Gly Pro Leu Val Cys Lys Val Asn Gly Thr Trp Leu Gln 195 200 205 Ala Gly Val Val Ser Trp Gly Glu Gly Cys Ala Gln Pro Asn Arg Pro 210 215 220 Gly Ile Tyr Thr Arg Val Thr Tyr Tyr Leu Asp Trp Ile His His Tyr 225 230 235 240 Val Pro Lys Lys Pro Gly Asn Ser Asp Tyr Lys Asp Asp Asp Asp Lys 245 250 255 < 210 > 117 < 211 > 256 < 212 > PRT < 213 > Homo sapiens < 400 > 117 Ile Val Gly Gly Gln Glu Ala Pro Arg Ser Lys Trp Pro Trp Gln Val 1 5 10 15 Ser Leu Arg Val Arg Asp Arg Tyr Trp Met His Phe Cys Gly Gly Ser 20 25 30 Leu Ile His Pro Gln Trp Val Leu Thr Ala Ala His Cys Val Gly Pro 35 40 45 Asp Val Lys Asp Leu Ala Ala Leu Arg Val Gln Leu Arg Glu Gln His 50 55 60 Leu Tyr Tyr Gln Asp Gln Leu Leu Pro Val Ser Arg Ile Ile Val His 65 70 75 80 Pro Gln Phe Tyr Thr Ala Gln Ile Gly Ala Asp Ile Ala Leu Leu Glu 85 90 95 Leu Glu Glu Pro Val Asn Val Ser Ser His Val His Thr Val Thr Leu 100 105 110 Pro Pro Ala Ser Glu Thr Phe Pro Pro Gly Met Pro Cys Trp Val Thr 115 120 125 Gly Trp Gly Asp Val Asp Asn Asp Glu Arg Leu Pro Pro Pro Phe Pro 130 135 140 Leu Lys Gln Val Lys Val Pro Ile Met Glu Asn His Ile Cys Asp Ala 145 150 155 160 Lys Tyr His Leu Gly Ala Tyr Thr Gly Asp Asp Val Arg Ile Val Arg 165 170 175 Asp Asp Met Leu Cys Ala Gly Asn Thr Arg Arg Asp Ser Cys Gln Gly 180 185 190 Asp Ser Gly Gly Pro Leu Val Cys Lys Val Asn Gly Thr Trp Leu Gln 195 200 205 Ala Gly Val Val Ser Trp Gly Glu Gly Cys Ala Gln Pro Asn Arg Pro 210 215 220 Gly Ile Tyr Thr Arg Val Thr Tyr Tyr Leu Asp Trp Ile His His Tyr 225 230 235 240 Val Pro Lys Lys Pro Gly Asn Ser Asp Tyr Lys Asp Asp Asp Asp Lys 245 250 255 < 210 > 118 < 211 > 256 < 212 > PRT < 213 > Homo sapiens < 400 > 118 Ile Val Gly Gly Gln Glu Ala Pro Arg Ser Lys Trp Pro Trp Gln Val 1 5 10 15 Ser Leu Arg Val Arg Asp Arg Tyr Trp Met His Phe Cys Gly Gly Ser 20 25 30 Leu Ile His Pro Gln Trp Val Leu Thr Ala Ala His Cys Leu Gly Pro 35 40 45 Asp Val Lys Asp Leu Ala Ala Leu Arg Val Gln Leu Arg Glu Gln His 50 55 60 Leu Tyr Tyr Gln Asp Gln Leu Leu Pro Val Ser Arg Ile Ile Val His 65 70 75 80 Pro Gln Phe Tyr Ile Ile Gln Thr Gly Ala Asp Ile Ala Leu Leu Glu 85 90 95 Leu Glu Glu Pro Val Asn Ile Ser Ser Arg Val His Thr Val Met Leu 100 105 110 Pro Pro Ala Ser Glu Thr Phe Pro Pro Gly Met Pro Cys Trp Val Thr 115 120 125 Gly Trp Gly Asp Val Asp Asn Asp Glu Pro Leu Ser Pro Pro Phe Pro 130 135 140 Leu Lys Gln Val Lys Val Pro Ile Met Glu Asn His Ile Cys Asp Ala 145 150 155 160 Lys Tyr His Leu Gly Ala Tyr Thr Gly Asp Asp Val Arg Ile Ile Arg 165 170 175 Asp Asp Met Leu Cys Ala Gly Asn Ser Gln Arg Asp Ser Cys Lys Gly 180 185 190 Asp Ser Gly Gly Pro Leu Val Cys Lys Val Asn Gly Thr Trp Leu Gln 195 200 205 Ala Gly Val Val Ser Trp Asp Glu Gly Cys Ala Gln Pro Asn Arg Pro 210 215 220 Gly Ile Tyr Thr Arg Val Thr Tyr Tyr Leu Asp Trp Ile His His Tyr 225 230 235 240 Val Pro Lys Lys Pro Gly Asn Ser Asp Tyr Lys Asp Asp Asp Asp Lys 245 250 255 < 210 > 119 < 211 > 268 < 212 > PRT < 213 > Macaca fascicularis < 400 > 119 Ala Leu Pro Val Leu Val Ser Pro Ala His Ala Ala Pro Ala Pro Gly 1 5 10 15 Gln Ala Leu Gln Arg Val Gly Ile Val Gly Gly Lys Glu Ala Pro Arg 20 25 30 Ser Lys Trp Pro Trp Gln Val Ser Leu Arg Leu His Gly Gln Tyr Trp 35 40 45 Met His Phe Cys Gly Gly Ser Leu Ile His Pro Gln Trp Val Leu Thr 50 55 60 Ala Ala His Cys Val Gly Pro Asp Val Lys Asp Leu Ala Asp Leu Arg 65 70 75 80 Val Gln Leu Arg Glu Gln His Leu Tyr Tyr Gln Asp Gln Leu Leu Pro 85 90 95 Val Ser Arg Ile Ile Val His Pro Gln Phe Tyr Ala Val Gln Ile Gly 100 105 110 Ala Asp Ile Ala Leu Leu Glu Leu Glu Glu Pro Val Asn Val Ser Ser 115 120 125 His Val His Thr Val Thr Leu Pro Pro Ala Leu Glu Thr Phe Pro Pro 130 135 140 Gly Thr Pro Cys Trp Val Thr Gly Trp Gly Asp Val Asp Asn Asp Val 145 150 155 160 Arg Leu Pro Pro Pro Tyr Pro Leu Lys Glu Val Glu Val Pro Ile Val 165 170 175 Glu Asn Gln Leu Cys Asp Ala Glu Tyr His Thr Gly Leu His Thr Gly 180 185 190 Asp Ser Phe Arg Ile Val Arg Asp Asp Met Leu Cys Ala Gly Ser Glu 195 200 205 Lys His Asp Ser Cys Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Lys 210 215 220 Val Asn Gly Thr Trp Leu Gln Ala Gly Val Val Ser Trp Gly Glu Gly 225 230 235 240 Cys Ala Leu Pro Asn Arg Pro Gly Ile Tyr Thr Arg Val Thr Tyr Tyr 245 250 255 Leu Asp Trp Ile His Arg Tyr Val Pro Glu Lys Pro 260 265 < 210 > 120 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 120 Ser Phe Ser Met Ser 1 5 < 210 > 121 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 121 Thr Ile Ser Gly Gly Lys Thr Phe Thr Asp Tyr Val Asp Ser Val Lys 1 5 10 15 Gly < 210 > 122 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 122 Ala Asn Tyr Gly Asn Trp Phe Phe Glu Val 1 5 10 < 210 > 123 < 211 > 15 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 123 Arg Ala Ser Glu Ser Val Ala Lys Tyr Gly Leu Ser Leu Leu Asn 1 5 10 15 < 210 > 124 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 124 Ala Ala Ser Asn Arg Gly Ser 1 5 < 210 > 125 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 125 Gln Gln Ser Lys Glu Val Pro Phe Thr 1 5 < 210 > 126 < 211 > 119 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 126 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Thr Ile Ser Gly Gly Lys Thr Phe Thr Asp Tyr Val Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Thr Arg Ala Asn Tyr Gly Asn Trp Phe Phe Glu Val Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 < 210 > 127 < 211 > 111 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 127 Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Ala Lys Tyr 20 25 30 Gly Leu Ser Leu Leu Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 35 40 45 Arg Leu Leu Ile Phe Ala Ala Ser Asn Arg Gly Ser Gly Ile Pro Ala 50 55 60 Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 65 70 75 80 Ser Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Ser Lys 85 90 95 Glu Val Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 110 < 210 > 128 < 211 > 260 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic Construct < 400 > 128 Ala Gly Ser Thr His His His His His His Asp Asp Asp Asp Lys Ile 1 5 10 15 Val Gly Gly Gln Glu Ala Pro Arg Ser Lys Trp Pro Trp Gln Val Ser 20 25 30 Leu Arg Val His Gly Pro Tyr Trp Met His Phe Cys Gly Gly Ser Leu 35 40 45 Ile His Pro Gln Trp Val Leu Thr Ala Ala His Cys Val Gly Pro Asp 50 55 60 Val Lys Asp Leu Ala Ala Leu Arg Val Gln Leu Arg Glu Gln His Leu 65 70 75 80 Tyr Tyr Gln Asp Gln Leu Leu Pro Val Ser Arg Ile Ile Val His Pro 85 90 95 Gln Phe Tyr Thr Ala Gln Ile Gly Ala Asp Ile Ala Leu Leu Glu Leu 100 105 110 Glu Glu Pro Val Asn Val Ser Ser His Val His Thr Val Thr Leu Pro 115 120 125 Pro Ala Ser Glu Thr Phe Pro Pro Gly Met Pro Cys Trp Val Thr Gly 130 135 140 Trp Gly Asp Val Asp Asn Asp Glu Arg Leu Pro Pro Pro Phe Pro Leu 145 150 155 160 Lys Gln Val Lys Val Pro Ile Met Glu Asn His Ile Cys Asp Ala Lys 165 170 175 Tyr His Leu Gly Ala Tyr Thr Gly Asp Asp Val Arg Ile Val Arg Asp 180 185 190 Asp Met Leu Cys Ala Gly Asn Thr Arg Arg Asp Ser Cys Gln Gly Asp 195 200 205 Ser Gly Gly Pro Leu Val Cys Lys Val Asn Gly Thr Trp Leu Gln Ala 210 215 220 Gly Val Val Ser Trp Gly Glu Gly Cys Ala Gln Pro Asn Arg Pro Gly 225 230 235 240 Ile Tyr Thr Arg Val Thr Tyr Tyr Leu Asp Trp Ile His His Tyr Val 245 250 255 Pro Lys Lys Pro 260