SEQUENCE LISTING < 110 > Dana - Farber Cancer Institute , Inc . Burnham Institute for Medical Research Marasco , Wayne A . Sui , Jianhua Liddington , Robert C . < 120 > Antibodies Against Influenza Virus and Methods of Use Thereof < 130 > 20363 - 049001 WO < 140 > PCT / US 2008 / 085876 < 141 > 2008 - 12 - 08 < 150 > 61 / 005 , 725 < 151 > 2007 - 12 - 06 < 150 > 61 / 091 , 599 < 151 > 2008 - 08 - 25 < 160 > 102 < 170 > PatentIn version 3 . 5 < 210 > 1 < 211 > 369 < 212 > DNA < 213 > Homo sapiens < 400 > 1 caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60 tcctgcaagg cttctggagg caccttcagt gacaatgcta tcagctgggt gcgacaggcc 120 ccaggacaag ggcttgagtg gatggggggc atcattccta tctttggaaa accaaactac 180 gcacagaagt tccagggcag agtcacgatt actgcggacg aatccacgag cacagcctac 240 atggacctga ggagcctgag atctgaggac acggccgttt attactgtgc gagagattca 300 gacgcgtatt actatggttc ggggggtatg gacgtctggg gccaaggcac cctggtcacc 360 gtctcctca 369 < 210 > 2 < 211 > 123 < 212 > PRT < 213 > Homo sapiens < 400 > 2 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Asp Asn 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Pro Ile Phe Gly Lys Pro Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Ser Thr Ala Tyr 65 70 75 80 Met Asp Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Asp Ser Asp Ala Tyr Tyr Tyr Gly Ser Gly Gly Met Asp Val 100 105 110 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 < 210 > 3 < 211 > 335 < 212 > DNA < 213 > Homo sapiens < 400 > 3 ctgcctgtgc tgactcaatc atcctctgcc tctgcttccc tgggatcctc ggtcaagctc 60 acctgcactc tgagcagtgg gcatagtaac tacatcatcg catggcatca acagcagcca 120 gggaaggccc ctcggtactt gatgaaggtt aatagtgatg gcagccacac caagggggac 180 gggatccctg atcgcttctc aggctccagc tctggggctg accgctacct caccatctcc 240 aacctccagt ctgaggatga ggctagttat ttctgtgaga cctgggacac taagattcat 300 gtcttcggaa ctgggaccaa ggtctccgtc ctcag 335 < 210 > 4 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 400 > 4 Leu Pro Val Leu Thr Gln Ser Ser Ser Ala Ser Ala Ser Leu Gly Ser 1 5 10 15 Ser Val Lys Leu Thr Cys Thr Leu Ser Ser Gly His Ser Asn Tyr Ile 20 25 30 Ile Ala Trp His Gln Gln Gln Pro Gly Lys Ala Pro Arg Tyr Leu Met 35 40 45 Lys Val Asn Ser Asp Gly Ser His Thr Lys Gly Asp Gly Ile Pro Asp 50 55 60 Arg Phe Ser Gly Ser Ser Ser Gly Ala Asp Arg Tyr Leu Thr Ile Ser 65 70 75 80 Asn Leu Gln Ser Glu Asp Glu Ala Ser Tyr Phe Cys Glu Thr Trp Asp 85 90 95 Thr Lys Ile His Val Phe Gly Thr Gly Thr Lys Val Ser Val Leu 100 105 110 < 210 > 5 < 211 > 363 < 212 > DNA < 213 > Homo sapiens < 400 > 5 caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60 tcctgcaagg ctcctggagg tatcttcaac accaatgctt tcagctgggt ccgacaggcc 120 cctggacaag gtcttgagtg ggtgggaggg gtcatccctt tgtttcgaac agcaagctac 180 gcacagaacg tccagggcag agtcaccatt accgcggacg aatccacgaa cacagcctac 240 atggagctta ccagcctgag atctgcggac acggccgtgt attactgtgc gagaagtagt 300 ggttaccatt ttaggagtca ctttgactcc tggggcctgg gaaccctggt caccgtctcc 360 tca 363 < 210 > 6 < 211 > 121 < 212 > PRT < 213 > Homo sapiens < 400 > 6 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Pro Gly Gly Ile Phe Asn Thr Asn 20 25 30 Ala Phe Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Val 35 40 45 Gly Gly Val Ile Pro Leu Phe Arg Thr Ala Ser Tyr Ala Gln Asn Val 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Tyr 65 70 75 80 Met Glu Leu Thr Ser Leu Arg Ser Ala Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Ser Gly Tyr His Phe Arg Ser His Phe Asp Ser Trp Gly 100 105 110 Leu Gly Thr Leu Val Thr Val Ser Ser 115 120 < 210 > 7 < 211 > 363 < 212 > DNA < 213 > Homo sapiens < 400 > 7 caggtgcagc tggtgcaatc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60 tcctgcaagg ctcctggagg tatcttcaac accaatgctt tcagctgggt ccgacaggcc 120 cctggacaag gtcttgagtg ggtgggaggg gtcatccctt tgtttcgaac agcaagctac 180 gcacagaacg tccagggcag agtcaccatt accgcggacg aatccacgaa cacagcctac 240 atggagctta ccagcctgag atctgcggac acggccgtgt attactgtgc gagaagtagt 300 ggttaccatt ttaggagtca ctttgactcc tggggcctgg gaaccctggt caccgtctcc 360 tca 363 < 210 > 8 < 211 > 111 < 212 > PRT < 213 > Homo sapiens < 400 > 8 Asn Phe Met Leu Thr Gln Pro His Ser Val Ser Ala Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Gly Ser Ser Gly Asn Ile Ala Ala Asn 20 25 30 Tyr Val Gln Trp Tyr Gln Gln Arg Pro Gly Ser Ala Pro Thr Thr Val 35 40 45 Ile Tyr Glu Asp Asp Arg Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Ile Asp Arg Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Tyr Asp Thr 85 90 95 Asn Asn His Ala Val Phe Gly Gly Gly Thr His Leu Thr Val Leu 100 105 110 < 210 > 9 < 211 > 333 < 212 > DNA < 213 > Homo sapiens < 400 > 9 aattttatgc tgactcagcc ccactctgtg tcggcgtctc cggggaagac ggtgaccatc 60 tcctgcaccg gcagcagtgg caacattgcc gccaactatg tgcagtggta ccaacaacgt 120 ccgggcagtg cccccactac tgtgatctat gaggatgacc gaagaccctc tggggtccct 180 gatcggttct ctggctccat cgacaggtcc tccaactctg cctccctcac catctcagga 240 ctgaagactg aggacgaggc tgactactac tgtcagactt atgataccaa caatcatgct 300 gtgttcggag gaggcaccca cctgaccgtc ctc 333 < 210 > 10 < 211 > 110 < 212 > PRT < 213 > Homo sapiens < 400 > 10 Ser Tyr Glu Leu Thr Gln Pro Pro Ser Ala Ser Gly Lys His Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Gly Thr Ser Asn Ile Gly Arg Asn 20 25 30 His Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Glu Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Val Ser Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Asp Asn Leu 85 90 95 Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 11 < 211 > 330 < 212 > DNA < 213 > Homo sapiens < 400 > 11 tcctatgagc tgactcagcc accctcagcg tctgggaaac acgggcagag ggtcaccatc 60 tcttgttctg gaggcacctc caacatcgga cgtaatcatg ttaactggta ccagcaactc 120 ccaggaacgg cccccaaact cctcatctat agtaatgaac agcggccctc aggggtccct 180 gaccgattct ctggctccaa atctggcacc tccgcctccc tggccgtgag tgggctccag 240 tctgaggatg aggctgatta ttactgtgca tcatgggatg acaacttgag tggttgggtg 300 ttcggcggag ggaccaagct gaccgtccta 330 < 210 > 12 < 211 > 120 < 212 > PRT < 213 > Homo sapiens < 400 > 12 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Thr Phe Ser Ala Tyr 20 25 30 Ala Phe Thr Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Thr Gly Met Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Leu Thr Ser Thr Ala Tyr 65 70 75 80 Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 85 90 95 Ala Arg Gly Leu Tyr Tyr Tyr Glu Ser Ser Leu Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 < 210 > 13 < 211 > 361 < 212 > DNA < 213 > Homo sapiens < 400 > 13 caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60 tcctgcaagg cttctggagg caccttcagc gcttatgctt tcacctgggt gcggcaggcc 120 cctggacaag ggcttgagtg gatgggaggc atcaccggaa tgtttggcac agcaaactac 180 gcacagaagt tccagggcag agtcacgatt accgcggacg aactcacgag cacagcctac 240 atggagttga gctccctgac atctgaagac acggcccttt attattgtgc gagaggattg 300 tattactatg agagtagtct tgactattgg ggccagggaa ccctggtcac cgtctcctca 360 g 361 < 210 > 14 < 211 > 110 < 212 > PRT < 213 > Homo sapiens < 400 > 14 Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Ser Pro Gly Gln 1 5 10 15 Ser Val Thr Ile Ser Cys Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr 20 25 30 Asn Ser Val Ser Trp Tyr Gln Gln His Pro Gly Lys Ala Pro Lys Leu 35 40 45 Met Ile Tyr Glu Val Thr Lys Arg Pro Ser Gly Val Pro Asp Arg Phe 50 55 60 Ser Ala Ser Lys Ser Gly Asn Thr Ala Ser Leu Thr Val Ser Gly Leu 65 70 75 80 Gln Ala Glu Asp Glu Ala Asp Tyr Phe Cys Cys Ser Tyr Ala Gly His 85 90 95 Ser Ala Tyr Val Phe Gly Thr Gly Thr Lys Val Thr Val Leu 100 105 110 < 210 > 15 < 211 > 361 < 212 > DNA < 213 > Homo sapiens < 400 > 15 caggtgcagc tggtgcagtc tggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60 tcctgcaggg cttctggagg caccttcagc gcttatgctt tcacctgggt gcggcaggcc 120 cctggacaag ggcttgagtg gatgggaggc atcaccggaa tgtttggcac agcaaactac 180 gcacagaagt tccagggcag agtcacgatt accgcggacg aactcacgag cacagcctac 240 atggagttga gctccctgac atctgaagac acggcccttt attattgtgc gagaggattg 300 tattactatg agagtagtct tgactattgg ggccagggaa ccctggtcac cgtctcctca 360 g 361 < 210 > 16 < 211 > 108 < 212 > PRT < 213 > Homo sapiens < 400 > 16 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Leu Ser Ser Lys 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Ser Cys Gln Gln Tyr Asp Gly Val Pro 85 90 95 Arg Thr Phe Gly Gln Gly Thr Thr Val Glu Ile Lys 100 105 < 210 > 17 < 211 > 330 < 212 > DNA < 213 > Homo sapiens < 400 > 17 cagtctgtgc tgactcagcc accctccgcg tccgggtctc ctggacagtc agtcaccatc 60 tcctgcactg gaaccagcag tgacgttggt ggttataact ctgtctcctg gtaccaacag 120 cacccaggca aagcccccaa actcatgatt tatgaggtca ctaagcggcc ctcaggggtc 180 cctgatcgct tctctgcctc caagtctggc aacacggcct ccctgaccgt ctctgggctc 240 caggctgagg atgaggctga ttatttctgc tgctcatatg caggccacag tgcttatgtc 300 ttcggaactg ggaccaaggt caccgtcctg 330 < 210 > 18 < 211 > 124 < 212 > PRT < 213 > Homo sapiens < 400 > 18 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Thr Ser Ser Glu Val Thr Phe Ser Ser Phe 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Leu 35 40 45 Gly Gly Ile Ser Pro Met Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Gln Ser Thr Arg Thr Ala Tyr 65 70 75 80 Met Asp Leu Arg Ser Leu Arg Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Ser Pro Ser Tyr Ile Cys Ser Gly Gly Thr Cys Val Phe Asp 100 105 110 His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 115 120 < 210 > 19 < 211 > 324 < 212 > DNA < 213 > Homo sapiens < 400 > 19 gaaattgtgc tgactcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtcttagc agcaagtact tagcctggta tcagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcaccc tcaccatcag tagactggag 240 cctgaagatt ttgcagtgta ttcctgtcag cagtatgatg gcgtacctcg gacgttcggc 300 caagggacca cggtggaaat caaa 324 < 210 > 20 < 211 > 110 < 212 > PRT < 213 > Homo sapiens < 400 > 20 Gln Pro Gly Leu Thr Gln Pro Pro Ser Val Ser Lys Gly Leu Arg Gln 1 5 10 15 Thr Ala Thr Leu Thr Cys Thr Gly Asn Ser Asn Asn Val Gly Asn Gln 20 25 30 Gly Ala Ala Trp Leu Gln Gln His Gln Gly His Pro Pro Lys Leu Leu 35 40 45 Ser Tyr Arg Asn Asn Asp Arg Pro Ser Gly Ile Ser Glu Arg Phe Ser 50 55 60 Ala Ser Arg Ser Gly Asn Thr Ala Ser Leu Thr Ile Thr Gly Leu Gln 65 70 75 80 Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Thr Trp Asp Ser Ser Leu 85 90 95 Ser Ala Val Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 21 < 211 > 372 < 212 > DNA < 213 > Homo sapiens < 400 > 21 caggtgcagc tggtgcagtc aggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60 tcctgcacgt cctctgaagt caccttcagt agttttgcta tcagctgggt gcgacaggcc 120 cctggacaag ggcttgagtg gctgggaggg atcagcccta tgtttggaac acctaattac 180 gcgcagaagt tccaaggcag agtcaccatt accgcggacc agtccacgag gacagcctac 240 atggacctga ggagcctgag atctgaggac acggccgtgt attattgtgc gagatctcct 300 tcttacattt gttctggtgg aacctgcgtc tttgaccatt ggggccaggg aaccctggtc 360 accgtctcct ca 372 < 210 > 22 < 211 > 107 < 212 > PRT < 213 > Homo sapiens < 400 > 22 Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Tyr 20 25 30 Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Ala Ala Ser Ser Leu Gln Arg Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asp Ser Ser Pro Tyr 85 90 95 Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 23 < 211 > 372 < 212 > DNA < 213 > Homo sapiens < 400 > 23 caggtacagc tgcagcagtc aggggctgag gtgaagaagc ctgggtcctc ggtgaaggtc 60 tcctgcacgt cctctgaagt caccttcagt agttttgcta tcagctgggt gcgacaggcc 120 cctggacaag ggcttgagtg gctgggaggg atcagcccta tgtttggaac acctaattac 180 gcgcagaagt tccaaggcag agtcaccatt accgcggacc agtccacgag gacagcctac 240 atggacctga ggagcctgag atctgaggac acggccgtgt attattgtgc gagatctcct 300 tcttacattt gttctggtgg aacctgcgtc tttgaccatt ggggccaggg aaccctggtc 360 accgtctcct ca 372 < 210 > 24 < 211 > 122 < 212 > PRT < 213 > Homo sapiens < 400 > 24 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Thr Ser Gly Val Thr Phe Ser Ser Tyr 20 25 30 Ala Ile Ser Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ile Gly Val Phe Gly Val Pro Lys Tyr Ala Gln Asn Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Lys Pro Thr Ser Thr Val Tyr 65 70 75 80 Met Glu Leu Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Glu Pro Gly Tyr Tyr Val Gly Lys Asn Gly Phe Asp Val Trp 100 105 110 Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 < 210 > 25 < 211 > 330 < 212 > DNA < 213 > Homo sapiens < 400 > 25 cagcctgggc tgactcagcc accctcggtg tccaagggct tgagacagac cgccacactc 60 acctgcactg ggaacagcaa caatgttggc aaccaaggag cagcttggct gcagcagcac 120 cagggccacc ctcccaaact cctatcctac aggaataatg accggccctc agggatctca 180 gagagattct ctgcatccag gtcaggaaac acagcctccc tgaccattac tggactccag 240 cctgaggacg aggctgacta ttactgctca acatgggaca gcagcctcag tgctgtggta 300 ttcggcggag ggaccaagct gaccgtccta 330 < 210 > 26 < 211 > 110 < 212 > PRT < 213 > Homo sapiens < 400 > 26 Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Lys Gly Leu Arg Gln 1 5 10 15 Thr Ala Ile Leu Thr Cys Thr Gly Asp Ser Asn Asn Val Gly His Gln 20 25 30 Gly Thr Ala Trp Leu Gln Gln His Gln Gly His Pro Pro Lys Leu Leu 35 40 45 Ser Tyr Arg Asn Gly Asn Arg Pro Ser Gly Ile Ser Glu Arg Phe Ser 50 55 60 Ala Ser Arg Ser Gly Asn Thr Ala Ser Leu Thr Ile Ile Gly Leu Gln 65 70 75 80 Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Ser Val Trp Asp Ser Ser Leu 85 90 95 Ser Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 110 < 210 > 27 < 211 > 321 < 212 > DNA < 213 > Homo sapiens < 400 > 27 gacatccaga tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gagcattagc agctatttaa attggtatca gcagaaacca 120 gggaaagccc ctaagctcct gatctatgct gcatccagtt tgcaaagagg ggtcccatca 180 aggttcagtg gcagtggatc tgggacagac ttcactctca ccattagcag cctgcagcct 240 gaagattttg cagtgtatta ctgtcagcag tatgatagtt caccgtacac ttttggccag 300 gggaccaagg tagagatcaa a 321 < 210 > 28 < 211 > 126 < 212 > PRT < 213 > Homo sapiens < 400 > 28 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Arg Lys Pro Gly Ala 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Gly Tyr 20 25 30 Tyr Ile His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Trp Ile Asn Pro Met Thr Gly Gly Thr Asn Tyr Ala Gln Lys Phe 50 55 60 Gln Val Trp Val Thr Met Thr Arg Asp Thr Ser Ile Asn Thr Ala Tyr 65 70 75 80 Met Glu Val Ser Arg Leu Thr Ser Asp Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Gly Ala Ser Val Leu Arg Tyr Phe Asp Trp Gln Pro Glu Ala 100 105 110 Leu Asp Ile Trp Gly Leu Gly Thr Thr Val Thr Val Ser Ser 115 120 125 < 210 > 29 < 211 > 366 < 212 > DNA < 213 > Homo sapiens < 400 > 29 caggtgcagc tggtgcaatc tggggctgaa gtgaagaagc ctggggcctc agtgaaggtc 60 tcctgcaaga cttctggagt caccttcagc agctatgcta tcagttgggt gcgacaggcc 120 cctggacaag ggcttgagtg gatgggaggg atcatcggtg tctttggtgt accaaagtac 180 gcgcagaact tccagggcag agtcacaatt accgcggaca aaccgacgag tacagtctac 240 atggagctga acagcctgag agctgaggac acggccgtgt attactgtgc gagagagccc 300 gggtactacg taggaaagaa tggttttgat gtctggggcc aagggacaat ggtcaccgtc 360 tcttca 366 < 210 > 30 < 211 > 108 < 212 > PRT < 213 > Homo sapiens < 400 > 30 Gln Pro Val Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 1 5 10 15 Thr Ala Ser Ile Pro Cys Gly Gly Asn Asn Ile Gly Gly Tyr Ser Val 20 25 30 His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Leu Leu Val Ile Tyr 35 40 45 Asp Asp Lys Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ala 50 55 60 Asn Ser Gly Ser Thr Ala Thr Leu Thr Ile Ser Arg Val Glu Ala Gly 65 70 75 80 Asp Glu Gly Asp Tyr Tyr Cys Gln Val Trp Asp Ser Gly Asn Asp Arg 85 90 95 Pro Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 100 105 < 210 > 31 < 211 > 330 < 212 > DNA < 213 > Homo sapiens < 400 > 31 tcctatgagc tgactcagcc accctcggtg tccaagggct tgagacagac cgccatactc 60 acctgcactg gagacagcaa caatgttggc caccaaggta cagcttggct gcaacaacac 120 cagggccacc ctcccaaact cctatcctac aggaatggca accggccctc agggatctca 180 gagagattct ctgcatccag gtcaggaaat acagcctccc tgaccattat tggactccag 240 cctgaggacg aggctgacta ctactgctca gtatgggaca gcagcctcag tgcctgggtg 300 ttcggcggag ggaccaagct gaccgtccta 330 < 210 > 32 < 211 > 123 < 212 > PRT < 213 > Homo sapiens < 400 > 32 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Pro Phe Ser Met Thr 20 25 30 Ala Phe Thr Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ser Pro Ile Phe Arg Thr Pro Lys Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Asn 65 70 75 80 Met Glu Leu Thr Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Thr Leu Ser Ser Tyr Gln Pro Asn Asn Asp Ala Phe Ala Ile 100 105 110 Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 < 210 > 33 < 211 > 378 < 212 > DNA < 213 > Homo sapiens < 400 > 33 caggtgcagc tggtgcagtc tggggctgag gtgaggaagc ctggggcctc agtgaaggtc 60 tcatgtaagg cttctggata caccttcacc ggttattata ttcactgggt gcgacaggcc 120 cctggacaag gacttgagtg gatgggttgg atcaacccta tgactggtgg cacaaactat 180 gcacagaagt ttcaggtctg ggtcaccatg acccgggaca cgtccatcaa cacagcctac 240 atggaggtga gcaggctgac atctgacgac acggccgtgt attactgtgc gaggggggct 300 tccgtattac gatattttga ctggcagccc gaggctcttg atatctgggg cctcgggacc 360 acggtcaccg tctcctca 378 < 210 > 34 < 211 > 106 < 212 > PRT < 213 > Homo sapiens < 400 > 34 Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Phe Cys Gln Gln Tyr Gly Ser Ser Pro Gln 85 90 95 Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 < 210 > 35 < 211 > 324 < 212 > DNA < 213 > Homo sapiens < 400 > 35 cagcctgtgc tgactcagcc accctcggtg tcagtggccc caggacagac ggccagcatt 60 ccctgtgggg ggaacaacat tggaggctac agtgtacact ggtaccaaca aaagccgggc 120 caggcccccc tcttggtcat ttatgacgat aaagaccggc cctcagggat ccctgagcga 180 ttctctggcg ccaactctgg gagcacggcc accctgacaa tcagcagggt cgaagccggg 240 gatgagggcg actactactg tcaggtgtgg gatagtggta atgatcgtcc gctgttcggc 300 ggagggacca agctgaccgt ccta 324 < 210 > 36 < 211 > 123 < 212 > PRT < 213 > Homo sapiens < 400 > 36 Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ser 1 5 10 15 Ser Val Lys Val Ser Cys Lys Ala Ser Gly Gly Pro Phe Ser Met Thr 20 25 30 Ala Phe Thr Trp Leu Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 35 40 45 Gly Gly Ile Ser Pro Ile Phe Arg Thr Pro Lys Tyr Ala Gln Lys Phe 50 55 60 Gln Gly Arg Val Thr Ile Thr Ala Asp Glu Ser Thr Asn Thr Ala Asn 65 70 75 80 Met Glu Leu Thr Ser Leu Lys Ser Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Thr Leu Ser Ser Tyr Gln Pro Asn Asn Asp Ala Phe Ala Ile 100 105 110 Trp Gly Gln Gly Thr Met Val Thr Val Ser Ser 115 120 < 210 > 37 < 211 > 369 < 212 > DNA < 213 > Homo sapiens < 400 > 37 caggtgcagc tggtgcagtc tggggctgaa gtgaagaagc ctggctcctc ggtgaaggtt 60 tcctgcaagg cttctggagg ccccttcagc atgactgctt tcacctggct gcgacaggcc 120 cctggacaag ggcttgagtg gatgggtggg atcagcccta tctttcgtac accgaagtac 180 gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgaa cacagccaac 240 atggagctga ccagcctgaa atctgaggac acggccgtgt attactgtgc gagaaccctt 300 tcctcctacc aaccgaataa tgatgctttt gctatctggg gccaagggac aatggtcacc 360 gtctcttca 369 < 210 > 38 < 211 > 110 < 212 > PRT < 213 > Homo sapiens < 400 > 38 Leu Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln 1 5 10 15 Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 20 25 30 Thr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 35 40 45 Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Arg Ser Gly Thr Ser Ala Ser Leu Ala Ile Ile Gly Leu Arg 65 70 75 80 Pro Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Ser Arg Leu 85 90 95 Ser Ala Ser Leu Phe Gly Thr Gly Thr Thr Val Thr Val Leu 100 105 110 < 210 > 39 < 211 > 318 < 212 > DNA < 213 > Homo sapiens < 400 > 39 gaaattgtgt tgacgcagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct 120 ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc 180 aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag actggagcct 240 gaagattttg cagtctattt ctgtcagcag tatggtagct cacctcaatt cggccaaggg 300 acacgactgg agattaaa 318 < 210 > 40 < 211 > 369 < 212 > DNA < 213 > Homo sapiens < 400 > 40 caggtgcagc tggtgcagtc tggggctgaa gtgaagaagc ctggctcctc ggtgaaggtt 60 tcctgcaagg cttctggagg ccccttcagc atgactgctt tcacctggct gcgacaggcc 120 cctggacaag ggcttgagtg gatgggtggg atcagcccta tctttcgtac accgaagtac 180 gcacagaagt tccagggcag agtcacgatt accgcggacg aatccacgaa cacagccaac 240 atggagctga ccagcctgaa atctgaggac acggccgtgt attactgtgc gagaaccctt 300 tcctcctacc aaccgaataa tgatgctttt gctatctggg gccaagggac aatggtcacc 360 gtctcttca 369 < 210 > 41 < 400 > 41 000 < 210 > 42 < 211 > 330 < 212 > DNA < 213 > Homo sapiens < 400 > 42 ctgcctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc 60 tcttgttctg gaagcagctc caacatcgga agtaatactg taaactggta ccagcagctc 120 ccaggaacgg cccccaaact cctcatctat agtaataatc agcggccctc aggggtccct 180 gaccgattct ctggctccag gtcaggcacc tcagcctccc tggccatcat tggactccgg 240 cctgaggatg aagctgatta ttactgtcag tcgtatgaca gcaggctcag tgcttctctc 300 ttcggaactg ggaccacggt caccgtcctc 330 < 210 > 43 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Consensus Sequence < 400 > 43 Ser Tyr Ala Phe Ser 1 5 < 210 > 44 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 400 > 44 Thr Asn Ala Phe Ser 1 5 < 210 > 45 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 400 > 45 Ala Tyr Ala Phe Thr 1 5 < 210 > 46 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 400 > 46 Ser Phe Ala Ile Ser 1 5 < 210 > 47 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 400 > 47 Ser Tyr Ala Ile Ser 1 5 < 210 > 48 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 400 > 48 Gly Tyr Tyr Ile His 1 5 < 210 > 49 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 400 > 49 Met Thr Ala Phe Thr 1 5 < 210 > 50 < 211 > 5 < 212 > PRT < 213 > Homo sapiens < 400 > 50 Asp Asn Ala Ile Ser 1 5 < 210 > 51 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Consensus Sequence < 400 > 51 Gly Ile Ile Pro Met Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly < 210 > 52 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 400 > 52 Gly Val Ile Pro Leu Phe Arg Thr Ala Ser Tyr Ala Gln Asn Val Gln 1 5 10 15 Gly < 210 > 53 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 400 > 53 Gly Ile Ile Gly Met Phe Gly Thr Ala Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly < 210 > 54 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 400 > 54 Gly Ile Ser Pro Met Phe Gly Thr Pro Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly < 210 > 55 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 400 > 55 Gly Ile Ile Gly Val Phe Gly Val Pro Lys Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly < 210 > 56 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 400 > 56 Trp Ile Asn Pro Met Thr Gly Gly Thr Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Val < 210 > 57 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 400 > 57 Gly Ile Ser Pro Ile Phe Arg Thr Pro Lys Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly < 210 > 58 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 400 > 58 Gly Ile Ile Pro Ile Phe Gly Lys Pro Asn Tyr Ala Gln Lys Phe Gln 1 5 10 15 Gly < 210 > 59 < 211 > 12 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Consensus Sequence < 400 > 59 Ser Ser Gly Tyr Tyr Tyr Gly Gly Gly Phe Asp Val 1 5 10 < 210 > 60 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 400 > 60 Ser Ser Gly Tyr His Phe Gly Arg Ser His Phe Asp Ser 1 5 10 < 210 > 61 < 211 > 11 < 212 > PRT < 213 > Homo sapiens < 400 > 61 Gly Leu Tyr Tyr Tyr Glu Ser Ser Leu Asp Tyr 1 5 10 < 210 > 62 < 211 > 15 < 212 > PRT < 213 > Homo sapiens < 400 > 62 Ser Pro Ser Tyr Ile Cys Ser Gly Gly Thr Cys Val Phe Asp His 1 5 10 15 < 210 > 63 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 400 > 63 Glu Pro Gly Tyr Tyr Val Gly Lys Asn Gly Phe Asp Val 1 5 10 < 210 > 64 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 400 > 64 Gly Ala Ser Val Leu Arg Tyr Phe Asp Trp Gln Pro Glu Ala Leu Asp 1 5 10 15 Ile < 210 > 65 < 211 > 14 < 212 > PRT < 213 > Homo sapiens < 400 > 65 Thr Leu Ser Ser Tyr Gln Pro Asn Asn Asp Ala Phe Ala Ile 1 5 10 < 210 > 66 < 211 > 14 < 212 > PRT < 213 > Homo sapiens < 400 > 66 Asp Ser Asp Ala Tyr Tyr Tyr Gly Ser Gly Gly Met Asp Val 1 5 10 < 210 > 67 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 400 > 67 Thr Gly Ser Ser Ser Asn Ile Gly Asn Tyr Val Ala 1 5 10 < 210 > 68 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 400 > 68 Thr Gly Ser Ser Ser Asn Ile Ala Ala Asn Tyr Val Gln 1 5 10 < 210 > 69 < 211 > 14 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Consensus Sequence < 400 > 69 Thr Gly Thr Ser Ser Asp Val Gly Gly Tyr Asn Ser Val Ser 1 5 10 < 210 > 70 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 400 > 70 Thr Gly Asn Ser Asn Asn Val Gly Asn Gln Gly Ala Ala 1 5 10 < 210 > 71 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 400 > 71 Thr Gly Asp Ser Asn Asn Val Gly His Gln Gly Thr Ala 1 5 10 < 210 > 72 < 211 > 11 < 212 > PRT < 213 > Homo sapiens < 400 > 72 Gly Gly Asn Asn Ile Gly Gly Tyr Ser Val His 1 5 10 < 210 > 73 < 211 > 11 < 212 > PRT < 213 > Homo sapiens < 400 > 73 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 < 210 > 74 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 400 > 74 Arg Ala Ser Gln Ser Leu Ser Ser Lys Tyr Leu Ala 1 5 10 < 210 > 75 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 400 > 75 Thr Gly Ser Ser Ser Asn Ile Gly Asn Tyr Val Ala 1 5 10 < 210 > 76 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 400 > 76 Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Thr Val Asn 1 5 10 < 210 > 77 < 211 > 11 < 212 > PRT < 213 > Homo sapiens < 400 > 77 Arg Ala Ser Gln Ser Ile Ser Ser Tyr Leu Asn 1 5 10 < 210 > 78 < 211 > 12 < 212 > PRT < 213 > Homo sapiens < 400 > 78 Thr Leu Ser Ser Gly His Ser Asn Tyr Ile Ile Ala 1 5 10 < 210 > 79 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Consensus Sequence < 400 > 79 Ser Asn Ser Asp Arg Pro Ser 1 5 < 210 > 80 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 400 > 80 Glu Asp Asp Arg Arg Pro Ser 1 5 < 210 > 81 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 400 > 81 Glu Val Thr Lys Arg Pro Ser 1 5 < 210 > 82 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 400 > 82 Arg Asn Asn Asp Arg Pro Ser 1 5 < 210 > 83 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 400 > 83 Arg Asn Gly Asn Arg Pro Ser 1 5 < 210 > 84 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 400 > 84 Asp Asp Lys Asp Arg Pro Ser 1 5 < 210 > 85 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 400 > 85 Asp Ala Ser Asn Arg Ala Thr 1 5 < 210 > 86 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 400 > 86 Gly Ala Ser Ser Arg Ala Thr 1 5 < 210 > 87 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 400 > 87 Ser Asn Asn Gln Arg Pro Ser 1 5 < 210 > 88 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 400 > 88 Ala Ala Ser Ser Leu Gln Arg 1 5 < 210 > 89 < 211 > 7 < 212 > PRT < 213 > Homo sapiens < 400 > 89 Ser Asn Glu Gln Arg Pro Ser 1 5 < 210 > 90 < 211 > 11 < 212 > PRT < 213 > Homo sapiens < 400 > 90 Val Asn Ser Asp Gly Ser His Thr Lys Gly Asp 1 5 10 < 210 > 91 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Consensus Sequence < 400 > 91 Gln Ser Tyr Asp Ser Leu Ser Ala Tyr Val 1 5 10 < 210 > 92 < 211 > 10 < 212 > PRT < 213 > Homo sapiens < 400 > 92 Gln Ser Tyr Asp Thr Asn Asn His Ala Val 1 5 10 < 210 > 93 < 211 > 10 < 212 > PRT < 213 > Homo sapiens < 400 > 93 Cys Ser Tyr Ala Gly His Ser Ala Tyr Val 1 5 10 < 210 > 94 < 211 > 11 < 212 > PRT < 213 > Homo sapiens < 400 > 94 Ser Thr Trp Asp Ser Ser Leu Ser Ala Val Val 1 5 10 < 210 > 95 < 211 > 11 < 212 > PRT < 213 > Homo sapiens < 400 > 95 Ser Val Trp Asp Ser Ser Leu Ser Ala Trp Val 1 5 10 < 210 > 96 < 211 > 11 < 212 > PRT < 213 > Homo sapiens < 400 > 96 Gln Val Trp Asp Ser Gly Asn Asp Arg Pro Leu 1 5 10 < 210 > 97 < 211 > 9 < 212 > PRT < 213 > Homo sapiens < 400 > 97 Gln Gln Tyr Gly Ser Ser Pro Gln Val 1 5 < 210 > 98 < 211 > 9 < 212 > PRT < 213 > Homo sapiens < 400 > 98 Gln Gln Tyr Asp Gly Val Pro Arg Thr 1 5 < 210 > 99 < 211 > 11 < 212 > PRT < 213 > Homo sapiens < 400 > 99 Gln Ser Tyr Asp Ser Arg Leu Ser Ala Ser Leu 1 5 10 < 210 > 100 < 211 > 9 < 212 > PRT < 213 > Homo sapiens < 400 > 100 Gln Gln Tyr Asp Ser Ser Pro Tyr Thr 1 5 < 210 > 101 < 211 > 11 < 212 > PRT < 213 > Homo sapiens < 400 > 101 Ala Ser Trp Asp Asp Asn Leu Ser Gly Trp Val 1 5 10 < 210 > 102 < 211 > 9 < 212 > PRT < 213 > Homo sapiens < 400 > 102 Glu Thr Trp Asp Thr Lys Ile His Val 1 5