I ' m also curious about this and have another question , how to know which size to pick ? Do I want small one for extra tightness ? <| sep |> I LIKE IT ! <| sep |> Well , I can say this . Im lvl 205 i get 250 K Dna per run for now , and thats no way near what you have to pay to get the last mutation , so I had to run a couple times to get it I had about 200 K dna per run then . so if you are happy to have the amount of DNA you have and like to run several times to get a mutation you dont upgrade it , and if you dont wanna do that . you upgrade it xD last mutation cost 1 , 771 , 406 DNAedit my ETC is lvl 202 Im ec lvl 205 edit 2 some mutations you can upgrade to infinity it seem so it will get more expencive the more you upgrade it so to have a ton of DNA helps a lot !