근 골격계 | 바이오 스타 줄기세포 기술 연구원 
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 알츠하이머 
 Long - term Follow - up after Implantation of Autologous Adipose Tissue Derived Mesenchymal Stem Cells to Treat a Dog with Stifle Joint Osteoarthrosis 
 요약 : 
 A 5 - year - old castrated male Chihuahua weighing 1 . 54 kg was examined because of a several month history of progressive right hind limb lameness . Physical examination of the stifle joints revealed pain and a grade IV medial patellar luxation on the right stifle joint . The right and left stifle joints were associated with a lameness of grade 2 and grade 0 , respectively . Radiography revealed osteophytes or subchondral cystic lesions on the right and left stifle joints . Osteoarthrosis ( OA ) scores for the right and left stifle joints were 20 and 12 respectively . Combination of surgery and implantation of autologous adipose tissue derived mesenchymal stem cells ( aAT - MSCs ) was determined with informed consent . 1 × 106 aAT - MSCs suspended in PBS and 0 . 6 mL of hyaluronic acid were injected in the right stifle joint postoperatively . Osteoarthrosis scores and the lameness grade for the right and left stifle joints were 19 and 13 , and 0 and 0 19 months after treatment , respectively , and 14 and 15 , and 0 and 0 five years after treatment , respectively . This case report shows radiographical evidence of a decrease in osteophytes and subchondral cystic lesions on the stifle joint with OA after aAT - MSCs injection . 
 바이오 스타 줄기세포 기술 연구원 
 근 골격계 , 
 논문 , 
 퇴행 성 관절염 : 동물 모델 
 Intra - articular Injection of Mesenchymal Stem Cells for the Treatment of Osteoarthritis of the Knee : A Proof - of - Concept Clinical Trial 
 The WOMAC score improved at 6 months after injection in the high - dose group . The size of cartilage defect decreased while the volume of cartilage increased in the medial femoral and tibial condyles of the high - dose group . Arthroscopy showed that the size of cartilage defect decreased in the medial femoral and medial tibial condyles of the high - dose group . Histology demonstrated thick , hyaline - like cartilage regeneration . These results showed that intra - articular injection of 1 . 0 3 108 AD MSCs into the osteoarthritic knee improved function and pain of the knee joint without causing adverse events , and reduced cartilage defects by regeneration of hyaline - like articular cartilage 
 Establishment of efficacy and safety assessment of human adipose tissue - derived mesenchymal stem cells ( hATMSCs ) in a nude rat femoral segmental defect model 
 Human adipose tissue - derived mesenchymal stem cell ( hATMSC ) have emerged as a potentially powerful tool for bone repair , but an appropriate evaluation system has not been established . The purpose of this study was to establish a preclinical assessment system to evaluate the efficacy and safety of cell therapies in a nude rat bone defect model . Segmental defects ( 5 mm ) were created in the femoral diaphyses and transplanted with 
 cell media ( control ) , hydroxyapatite / tricalcium phosphate scaffolds ( HA / TCP , Group I ) , hATMSCs ( Group II ) , or three cell - loading density of hATMSC - loaded HA / TCP ( Group III - V ) . Healing response was evaluated by serial radiography , micro - computed tomography and histology at 16 weeks . To address safety - concerns , we conducted a GLP - compliant toxicity study . Scanning electron microscopy studies showed that hATMSCs filled the pores / surfaces of scaffolds in a cell - loading density - dependent manner . We detected significant increases in bone formation in the hATMSC - loaded HA / TCP groups compared with other groups . The amount of new bone formation increased with increases in loaded cell number . In a toxicity study , no significant hATMSC - related changes were found in body weights , clinical signs , hematological / biochemical values , organ weights , or histopathological findings . In conclusion , hATMSCs loaded on HA / TCP enhance the repair of bone defects and was found to be safe under our preclinical efficacy / safety hybrid assessment system . 
 골 결손 - 근 골격계 로 이동 , 
 Administering human adipose - derived mesenchymal stem cells to prevent and treat experimental arthritis . 
 Rheumatoid arthritis is a chronic autoimmune disease and affecting approximately 1 % of the population . Human adipose - derived mesenchymal stem cells ( hASCs ) were recently found to suppress effector T cell and inflammatory responses and , thus , to have beneficial effects in various autoimmune diseases . In this study , we examined whether hASCs could play a protective and / or therapeutic role in collagen - induced arthritis ( CIA ) . We showed that hASCs both prevented and treated CIA by significantly reducing the incidence and severity of experimental arthritis . We further demonstrated that treatment with hASCs inhibited the production of various inflammatory mediators , decreased antigen - specific Th 1 / Th 17 cell expansion , and induced the production of anti - inflammatory cytokine interleukin - 10 . Moreover , hASCs could induce the generation of antigen - specific Treg cells with the capacity to suppress collagen - specific T cell responses . 
 온라인 줄기세포 대학 
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 바이오 스타 줄기세포 기술 연구원 
 ( 우 ) 153 - 768 
 가산 디지털 2 로 98 , 2 동 305 호 
 ( 주 ) 알 바이오 
 대표자 : 라정찬 
 대표 번호 : + 82 - 2 - 858 - 8021 ~ 5 
 copd jointstem PNH 강남 세브 란스 병원 강동 경희대병원 관절 기능 개선 난치병 치료 난치성 질환 네이처 셀 뇌성 마비 닥터 쥬 크 르 라스 템스 위스 라정찬 만성 폐쇄성 폐질환 무릎 관절염 미국 FDA 바스코 스템 바이오 스타 버거병 버거 씨 병 보라매병원 세계 1 등 알 바이오 연골 재생 정맥 조인트 스템 줄기세포 줄기세포 배양액 화장품 줄기세포 생명 재단 중 간엽 줄기세포 중국 진출 중증 버거 씨 병 치매 태반 줄기세포 태반 줄기세포 퇴행 성 관절염 퇴행 성 관절염 특정 세포 가 공물 특허 피부 재생 피부 재생 센터 혈관 내 투여 후생 성 희 귀병 치료제 희귀 의약품 
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