The Imperium still used warp travel in the DAoT , which goes to show just how insanely advanced nonwarp travel is in the context of 40 k . For all we know , the warp and Chaos as we know it are all localised to the Milky Way . The huge distances to the next galaxies may act like calm belts . Entire DAoT empires maybe populate Andromeda , having never fallen into an Age of Strife , since they didn ' t experience the birth of Slaanesh and the warp fuckery that came with it . However DAoT humanity was still in its psychic infancy and without the guiding presence of E it ' s very likely any human empire would be at a high risk of chaos hijinks . We known Orks are out there someplace , so likely they would have to deal with them at a minimum , if not a Tyrnaid fleet . That ' s what i love about 40 k , the place is so massive , the timescales are huge and there is tons of vague lore that it makes so many scenarios plausible .