< 110 > Elan Pharmaceuticals , Inc . < 120 > Treatment and prophylaxis of amyloidosis < 130 > 021452 - 0376734 < 150 > US 61 / 007 , 544 < 151 > 2007 - 12 - 28 < 150 > US 61 / 095 , 932 < 151 > 2008 - 09 - 10 < 160 > 177 < 170 > KopatentIn 1 . 71 < 210 > 1 < 211 > 122 < 212 > PRT < 213 > Homo sapiens < 400 > 1 Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Gly Val 1 5 10 15 Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 20 25 30 Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 35 40 45 Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 50 55 60 Arg Gly Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asp Ala Arg 65 70 75 80 Glu Asn Ile Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser Leu Ala 85 90 95 Asp Gln Ala Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His 100 105 110 Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 115 120 < 210 > 2 < 211 > 76 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > Human amyloid protein A peptide < 400 > 2 Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala Arg Asp 1 5 10 15 Met Tyr Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile Gly Ser 20 25 30 Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys Arg Gly 35 40 45 Pro Gly Gly Ala Tyr Ala Ala Glu Val Ile Ser Asp Ala Arg Glu Asn 50 55 60 Ile Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser 65 70 75 < 210 > 3 < 211 > 5 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from amyloidosis peptide < 400 > 3 Gly His Glu Asp Thr 1 5 < 210 > 4 < 211 > 7 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from amyloid A protein < 400 > 4 Gly His Gly Ala Glu Asp Ser 1 5 < 210 > 5 < 211 > 7 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from amyloid A protein < 400 > 5 Gly His Asp Ala Glu Asp Ser 1 5 < 210 > 6 < 211 > 7 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from amyloid protein < 400 > 6 Gly His Gly Ala Glu Asp Ser 1 5 < 210 > 7 < 211 > 7 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from amyloid A protein < 400 > 7 Gly Asp His Ala Glu Asp Ser 1 5 < 210 > 8 < 211 > 7 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from amyloid A protein < 400 > 8 Ser Thr Val Ile Glu Asp Ser 1 5 < 210 > 9 < 211 > 7 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from amyloid A protein < 400 > 9 Gly Arg Gly His Glu Asp Thr 1 5 < 210 > 10 < 211 > 7 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from amyloid A protein < 400 > 10 Gly His Gly Ala Glu Asp Ser 1 5 < 210 > 11 < 211 > 7 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from amyloid A protein < 400 > 11 Asn His Gly Leu Glu Thr Leu 1 5 < 210 > 12 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from amyloidosis peptide < 400 > 12 His Glu Asp Thr 1 < 210 > 13 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 13 Ala Glu Asp Ser 1 < 210 > 14 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 14 Ala Glu Asp Thr 1 < 210 > 15 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 15 His Glu Asp Ala 1 < 210 > 16 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > AL V lambda fragment from amyloid protein < 400 > 16 Thr Glu Asp Glu 1 < 210 > 17 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > AL V lambda fragment from amyloid protein < 400 > 17 Phe Glu Asp Asp 1 < 210 > 18 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > AL V lambda fragment from amyloid protein < 220 > < 221 > MISC _ FEATURE < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 18 Ser Glu Asp Glu 1 < 210 > 19 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > AL V lambda fragment from amyloid protein < 220 > < 221 > MISC _ FEATURE < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 19 Ala Glu Asp Glu 1 < 210 > 20 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > AL V lambda fragment from amyloid protein < 400 > 20 Pro Glu Asp Glu 1 < 210 > 21 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > AL V kappa fragment from amyloid protein < 220 > < 221 > MISC _ FEATURE < 223 > Consensue sequence derived from human amyloidogenic proteins < 400 > 21 Pro Glu Asp Ile 1 < 210 > 22 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > AL V kappa fragment from amyloid protein < 220 > < 221 > MISC _ FEATURE < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 22 Pro Glu Asp Phe 1 < 210 > 23 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > AL V kappa fragment from amyloid protein < 220 > < 221 > MISC _ FEATURE < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 23 Ala Glu Asp Val 1 < 210 > 24 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > AL V kappa fragment from amyloid protein < 220 > < 221 > MISC _ FEATURE < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 24 Ser Glu Asp Phe 1 < 210 > 25 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > AL V kappa fragment from amyloid protein < 400 > 25 Ser Glu Asp Ala 1 < 210 > 26 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 26 Pro Glu Asp Ser 1 < 210 > 27 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 27 Pro Glu Asp Leu 1 < 210 > 28 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 28 Thr Glu Asp Val 1 < 210 > 29 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 29 Ser Glu Asp Ile 1 < 210 > 30 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 30 Thr Glu Asp Thr 1 < 210 > 31 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 31 Leu Glu Asp Gly 1 < 210 > 32 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 32 Ala Glu Asp Met 1 < 210 > 33 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 33 His Glu Asp Ser 1 < 210 > 34 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 34 Cys Glu Asp Asp 1 < 210 > 35 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 35 Gln Glu Asp Ser 1 < 210 > 36 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 36 Arg Glu Asp Ser 1 < 210 > 37 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 37 Thr Glu Asp Gly 1 < 210 > 38 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 38 Gln Glu Asp Arg 1 < 210 > 39 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 39 Thr Glu Asp Leu 1 < 210 > 40 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 40 Pro Glu Asp Asn 1 < 210 > 41 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 41 Glu Glu Asp Pro 1 < 210 > 42 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 42 Leu Glu Asp Leu 1 < 210 > 43 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 43 Lys Glu Asp Ala 1 < 210 > 44 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 44 Ser Glu Asp Cys 1 < 210 > 45 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 45 Glu Glu Asp Asp 1 < 210 > 46 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 46 Ser Glu Asp Lys 1 < 210 > 47 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 47 Asp Glu Asp Asp 1 < 210 > 48 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 48 Asp Glu Asp Gly 1 < 210 > 49 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 49 Leu Glu Asp Glu 1 < 210 > 50 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 50 Gly Glu Asp Ala 1 < 210 > 51 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 51 Val Glu Asp Phe 1 < 210 > 52 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 52 Tyr Glu Asp Glu 1 < 210 > 53 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 53 Ile Glu Asp Leu 1 < 210 > 54 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 54 Trp Glu Asp Tyr 1 < 210 > 55 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 55 Asp Glu Asp Trp 1 < 210 > 56 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 56 Ser Glu Asp Leu 1 < 210 > 57 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 57 Tyr Glu Asp Gln 1 < 210 > 58 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 58 Leu Glu Asp Trp 1 < 210 > 59 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 59 Tyr Glu Asp Arg 1 < 210 > 60 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 60 Pro Glu Asp Lys 1 < 210 > 61 < 211 > 10 < 212 > PRT < 213 > Artificial < 220 > < 223 > Non - amyloid portion of serum amyloid A protein < 400 > 61 Gly His Glu Asp Thr Met Ala Asp Gln Glu 1 5 10 < 210 > 62 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 62 Ala Glu Asp Ala 1 < 210 > 63 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 63 Gln Glu Asp Leu 1 < 210 > 64 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 64 Val Glu Asp Leu 1 < 210 > 65 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 65 Leu Glu Asp Ala 1 < 210 > 66 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 66 Ser Glu Asp Gly 1 < 210 > 67 < 211 > 16 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from Malaria CS < 220 > < 221 > MISC _ FEATURE < 223 > T 3 epitope < 400 > 67 Glu Lys Lys Ile Ala Lys Met Glu Lys Ala Ser Ser Val Phe Asn Val 1 5 10 15 < 210 > 68 < 211 > 10 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from Hepititis B surface antigen residues 19 - 28 < 400 > 68 Phe Phe Leu Leu Thr Arg Ile Leu Thr Ile 1 5 10 < 210 > 69 < 211 > 19 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from mycobacterium heat shock protein 65 residues 153 - 171 < 400 > 69 Asp Gln Ser Ile Gly Asp Leu Ile Ala Glu Ala Met Asp Lys Val Gly 1 5 10 15 Asn Glu Gly < 210 > 70 < 211 > 14 < 212 > PRT < 213 > Bicille calmette - guerin < 400 > 70 Gln Val His Phe Gln Pro Leu Pro Pro Ala Val Val Lys Leu 1 5 10 < 210 > 71 < 211 > 15 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from Tetanus toxoid residues 830 - 844 < 400 > 71 Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu 1 5 10 15 < 210 > 72 < 211 > 21 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from Tetanus toxoid residues 947 - 967 < 400 > 72 Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 1 5 10 15 Ala Ser His Leu Glu 20 < 210 > 73 < 211 > 16 < 212 > PRT < 213 > HIV < 220 > < 221 > MISC _ FEATURE < 223 > HIV gb 120 T 1 < 400 > 73 Lys Gln Ile Ile Asn Met Trp Gln Glu Val Gly Lys Ala Met Tyr Ala 1 5 10 15 < 210 > 74 < 211 > 13 < 212 > PRT < 213 > Artificial < 220 > < 223 > Pan DR epitope < 220 > < 221 > MISC _ FEATURE < 222 > ( 3 ) . .( 3 ) < 223 > Xaa can be any naturally occurring amino acid < 400 > 74 Ala Lys Xaa Val Ala Ala Trp Thr Leu Lys Ala Ala Ala 1 5 10 < 210 > 75 < 211 > 36 < 212 > PRT < 213 > Artificial < 220 > < 223 > Fusion protein derived from Tetanus toxoid residues 830 - 844 and 947 - 967 < 400 > 75 Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Phe 1 5 10 15 Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala 20 25 30 Ser His Leu Glu 35 < 210 > 76 < 211 > 17 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from ovalbumin residues 323 - 389 < 400 > 76 Ile Ser Gln Ala Val His Ala Ala His Ala Glu Ile Asn Glu Ala Gly 1 5 10 15 Arg < 210 > 77 < 211 > 13 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from hemagglutinin influenza A virus < 400 > 77 Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr 1 5 10 < 210 > 78 < 211 > 65 < 212 > PRT < 213 > Artificial < 220 > < 223 > Fusion protein derived from hemagglutinin influenza A residues 307 - 319 , Malaria CD : T 3 epitope , tetanus toxoid residues 830 - 844 and 947 - 967 < 400 > 78 Pro Lys Tyr Val Lys Gln Asn Thr Leu Lys Leu Ala Thr Glu Lys Lys 1 5 10 15 Ile Ala Lys Met Glu Lys Ala Ser Ser Val Phe Asn Val Gln Tyr Ile 20 25 30 Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Phe Asn Asn Phe 35 40 45 Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser Ala Ser His Leu 50 55 60 Glu 65 < 210 > 79 < 211 > 37 < 212 > PRT < 213 > Artificial < 220 > < 223 > Fusion protein < 400 > 79 Gln Tyr Ile Lys Ala Asn Ser Lys Phe Ile Gly Ile Thr Glu Leu Cys 1 5 10 15 Phe Asn Asn Phe Thr Val Ser Phe Trp Leu Arg Val Pro Lys Val Ser 20 25 30 Ala Ser His Leu Glu 35 < 210 > 80 < 211 > 15 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from human amyloid A protein < 400 > 80 Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala Arg 1 5 10 15 < 210 > 81 < 211 > 15 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from human amyloid A protein < 400 > 81 Gln Gly Trp Leu Thr Phe Leu Lys Ala Ala Gly Gln Gly Ala Lys 1 5 10 15 < 210 > 82 < 211 > 10 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from mouse amyloid A protein < 400 > 82 Glu Ser Trp Arg Ser Phe Phe Lys Glu Ala 1 5 10 < 210 > 83 < 211 > 15 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from mouse amyloid A protein < 400 > 83 Gly Phe Phe Ser Phe Val His Glu Ala Phe Gln Gly Ala Gly Asp 1 5 10 15 < 210 > 84 < 211 > 8 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from mouse amyloid A protein < 400 > 84 Glu Ala Gly Gln Gly Ser Arg Asp 1 5 < 210 > 85 < 211 > 14 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from mouse amyloid A protein < 400 > 85 Trp Tyr Ser Phe Phe Arg Glu Ala Val Gln Gly Thr Trp Asp 1 5 10 < 210 > 86 < 211 > 99 < 212 > PRT < 213 > Homo Sapiens < 220 > < 221 > MISC _ FEATURE < 223 > Lambda 2 fragments from human amyloid deposits < 400 > 86 Gly Ser Val Val Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Arg Gln 1 5 10 15 Thr Val Ala Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn 20 25 30 Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Lys Ala Pro Lys Val Leu 35 40 45 Ile Tyr Tyr Asp Asp Leu Leu Pro Ala Gly Val Ser Asp Arg Phe Ser 50 55 60 Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Arg Gly Leu Gln 65 70 75 80 Ser Glu Asp Glu Gly Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu 85 90 95 Ser Ala Leu < 210 > 87 < 211 > 7 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from serum amyloid A protein < 400 > 87 Cys Gly Gly His Glu Asp Thr 1 5 < 210 > 88 < 211 > 7 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from serum amyloid A protein < 400 > 88 Cys Gly Gly Ala Glu Asp Ser 1 5 < 210 > 89 < 211 > 10 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from serum amyloid A protein < 400 > 89 Gly His Glu Asp Thr Ile Ala Asp Gln Glu 1 5 10 < 210 > 90 < 211 > 7 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from serum amyloid A protein < 400 > 90 Cys Gly Gly Ala Glu Asp Thr 1 5 < 210 > 91 < 211 > 7 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from serum amyloid A protein < 400 > 91 Cys Gly Gly His Ala Asp Thr 1 5 < 210 > 92 < 211 > 7 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from serum amyloid A protein < 400 > 92 Cys Gly Gly His Glu Ala Thr 1 5 < 210 > 93 < 211 > 7 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from serum amyloid A protein < 400 > 93 Cys Gly Gly His Glu Asp Ala 1 5 < 210 > 94 < 211 > 8 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from serum amyloid A protein < 400 > 94 Cys Gly Gly His Glu Asp Thr Met 1 5 < 210 > 95 < 211 > 9 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from serum amyloid A protein < 400 > 95 Cys Gly Gly His Glu Asp Thr Met Ala 1 5 < 210 > 96 < 211 > 10 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from serum amyloid A protein < 400 > 96 Cys Gly Gly His Glu Asp Thr Met Ala Asp 1 5 10 < 210 > 97 < 211 > 6 < 212 > PRT < 213 > Artificial < 220 > < 223 > Derived from serum amyloid A protein < 400 > 97 Cys Gly Gly His Glu Asp 1 5 < 210 > 98 < 211 > 122 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > HSAA 1 < 400 > 98 Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Gly Val 1 5 10 15 Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 20 25 30 Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 35 40 45 Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 50 55 60 Arg Gly Pro Gly Gly Val Trp Ala Ala Glu Ala Ile Ser Asp Ala Arg 65 70 75 80 Glu Asn Ile Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser Leu Ala 85 90 95 Asp Gln Ala Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His 100 105 110 Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 115 120 < 210 > 99 < 211 > 122 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > HSAA 2 < 400 > 99 Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Ser Val 1 5 10 15 Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 20 25 30 Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 35 40 45 Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 50 55 60 Arg Gly Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asn Ala Arg 65 70 75 80 Glu Asn Ile Gln Arg Leu Thr Gly His Gly Ala Glu Asp Ser Leu Ala 85 90 95 Asp Gln Ala Ala Asn Lys Trp Gly Arg Ser Gly Arg Asp Pro Asn His 100 105 110 Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 115 120 < 210 > 100 < 211 > 122 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > HSAA 3 < 400 > 100 Met Lys Leu Ser Thr Gly Ile Ile Phe Cys Ser Leu Val Leu Gly Val 1 5 10 15 Ser Ser Gln Gly Trp Leu Thr Phe Leu Lys Ala Ala Gly Gln Gly Ala 20 25 30 Lys Asp Met Trp Arg Ala Tyr Ser Asp Met Lys Glu Ala Asn Tyr Lys 35 40 45 Lys Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Val Gln 50 55 60 Arg Gly Pro Gly Gly Val Trp Ala Thr Glu Val Ile Ser Asp Ala Arg 65 70 75 80 Glu Asn Val Gln Arg Leu Thr Gly Asp His Ala Glu Asp Ser Leu Ala 85 90 95 Gly Gln Ala Thr Asn Lys Trp Gly Gln Ser Gly Lys Asp Pro Asn His 100 105 110 Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 115 120 < 210 > 101 < 211 > 130 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > HSAA 4 < 400 > 101 Met Arg Leu Phe Thr Gly Ile Val Phe Cys Ser Leu Val Met Gly Val 1 5 10 15 Thr Ser Glu Ser Trp Arg Ser Phe Phe Lys Glu Ala Leu Gln Gly Val 20 25 30 Gly Asp Met Gly Arg Ala Tyr Trp Asp Ile Met Ile Ser Asn His Gln 35 40 45 Asn Ser Asn Arg Tyr Leu Tyr Ala Arg Gly Asn Tyr Asp Ala Ala Gln 50 55 60 Arg Gly Pro Gly Gly Val Trp Ala Ala Lys Leu Ile Ser Arg Ser Arg 65 70 75 80 Val Tyr Leu Gln Gly Leu Ile Asp Tyr Tyr Leu Phe Gly Asn Ser Ser 85 90 95 Thr Val Leu Glu Asp Ser Lys Ser Asn Glu Lys Ala Glu Glu Trp Gly 100 105 110 Arg Ser Gly Lys Asp Pro Asp Arg Phe Arg Pro Asp Gly Leu Pro Lys 115 120 125 Lys Tyr 130 < 210 > 102 < 211 > 76 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > HAA 1 < 400 > 102 Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala Arg Asp 1 5 10 15 Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile Gly Ser 20 25 30 Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys Arg Gly 35 40 45 Pro Gly Gly Val Trp Ala Ala Glu Ala Ile Ser Asp Ala Arg Glu Asn 50 55 60 Ile Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser 65 70 75 < 210 > 103 < 211 > 76 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > HAA 2 < 400 > 103 Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala Arg Asp 1 5 10 15 Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile Gly Ser 20 25 30 Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys Arg Gly 35 40 45 Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asn Ala Arg Glu Asn 50 55 60 Ile Gln Arg Leu Thr Gly His Gly Ala Glu Asp Ser 65 70 75 < 210 > 104 < 211 > 76 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > HAA 3 < 400 > 104 Gln Gly Trp Leu Thr Phe Leu Lys Ala Ala Gly Gln Gly Ala Lys Asp 1 5 10 15 Met Trp Arg Ala Tyr Ser Asp Met Lys Glu Ala Asn Tyr Lys Lys Ser 20 25 30 Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Val Gln Arg Gly 35 40 45 Pro Gly Gly Val Trp Ala Thr Glu Val Ile Ser Asp Ala Arg Glu Asn 50 55 60 Val Gln Arg Leu Thr Gly Asp His Ala Glu Asp Ser 65 70 75 < 210 > 105 < 211 > 84 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > HAA 4 < 400 > 105 Glu Ser Trp Arg Ser Phe Phe Lys Glu Ala Leu Gln Gly Val Gly Asp 1 5 10 15 Met Gly Arg Ala Tyr Trp Asp Ile Met Ile Ser Asn His Gln Asn Ser 20 25 30 Asn Arg Tyr Leu Tyr Ala Arg Gly Asn Tyr Asp Ala Ala Gln Arg Gly 35 40 45 Pro Gly Gly Val Trp Ala Ala Lys Leu Ile Ser Arg Ser Arg Val Tyr 50 55 60 Leu Gln Gly Leu Ile Asp Tyr Tyr Leu Phe Gly Asn Ser Ser Thr Val 65 70 75 80 Ile Glu Asp Ser < 210 > 106 < 211 > 117 < 212 > PRT < 213 > Mus musculus < 220 > < 221 > MISC _ FEATURE < 223 > MSAA 1 < 400 > 106 Met Lys Leu Leu Thr Ser Leu Val Phe Cys Ser Leu Leu Leu Gly Val 1 5 10 15 Cys His Gly Gly Phe Phe Ser Phe Val His Glu Ala Phe Gln Gly Ala 20 25 30 Gly Asp Met Trp Arg Ala Tyr Thr Asp Met Lys Glu Ala Asn Trp Lys 35 40 45 Asn Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Gln 50 55 60 Arg Gly Pro Gly Gly Val Trp Ala Ala Glu Lys Ile Ser Asp Gly Arg 65 70 75 80 Glu Ala Phe Gln Glu Phe Phe Gly Arg Ile Ala Asp Gln Glu Ala Asn 85 90 95 Arg His Gly Arg Ser Gly Lys Asp Pro Asn Tyr Tyr Arg Pro Pro Gly 100 105 110 Leu Pro Asp Lys Tyr 115 < 210 > 107 < 211 > 122 < 212 > PRT < 213 > Mus musculus < 220 > < 221 > MISC _ FEATURE < 223 > MSAA 2 < 400 > 107 Met Lys Leu Leu Thr Ser Leu Val Phe Cys Ser Leu Leu Leu Gly Val 1 5 10 15 Cys His Gly Gly Phe Phe Ser Phe Ile Gly Glu Ala Phe Gln Gly Ala 20 25 30 Gly Asp Met Trp Arg Ala Tyr Thr Asp Met Lys Glu Ala Gly Trp Lys 35 40 45 Asp Gly Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Gln 50 55 60 Arg Gly Pro Gly Gly Val Trp Ala Ala Glu Lys Ile Ser Asp Ala Arg 65 70 75 80 Glu Ser Phe Gln Glu Phe Phe Gly Arg Gly His Glu Asp Thr Met Ala 85 90 95 Asp Gln Glu Ala Asn Arg His Gly Arg Ser Gly Lys Asp Pro Asn Tyr 100 105 110 Tyr Arg Pro Pro Gly Leu Pro Ala Lys Tyr 115 120 < 210 > 108 < 211 > 122 < 212 > PRT < 213 > Mus musculus < 220 > < 221 > MISC _ FEATURE < 223 > MSAA 3 < 400 > 108 Met Lys Pro Ser Ile Ala Ile Ile Leu Cys Ile Leu Ile Leu Gly Val 1 5 10 15 Asp Ser Gln Arg Trp Val Gln Phe Met Lys Glu Ala Gly Gln Gly Ser 20 25 30 Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Lys Lys Ala Asn Trp Lys 35 40 45 Asn Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Arg 50 55 60 Arg Gly Pro Gly Gly Ala Trp Ala Ala Lys Val Ile Ser Asp Ala Arg 65 70 75 80 Glu Ala Val Gln Lys Phe Thr Gly His Gly Ala Glu Asp Ser Arg Ala 85 90 95 Asp Gln Phe Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His 100 105 110 Phe Arg Pro Ala Gly Leu Pro Lys Arg Tyr 115 120 < 210 > 109 < 211 > 130 < 212 > PRT < 213 > Mus musculus < 220 > < 221 > MISC _ FEATURE < 223 > MSAA 4 < 400 > 109 Met Arg Leu Ala Thr Val Ile Val Leu Cys Ser Leu Phe Leu Gly Val 1 5 10 15 Ser Gly Asp Gly Trp Tyr Ser Phe Phe Arg Glu Ala Val Gln Gly Thr 20 25 30 Trp Asp Leu Trp Arg Ala Tyr Arg Asp Asn Leu Glu Ala Asn Tyr Gln 35 40 45 Asn Ala Asp Gln Tyr Phe Tyr Ala Arg Gly Asn Tyr Glu Ala Gln Gln 50 55 60 Arg Gly Ser Gly Gly Ile Trp Ala Ala Lys Ile Ile Ser Thr Ser Arg 65 70 75 80 Lys Tyr Phe Gln Gly Leu Leu Asn Arg Tyr Tyr Phe Gly Ile Arg Asn 85 90 95 His Gly Leu Glu Thr Leu Gln Ala Thr Gln Lys Ala Glu Glu Trp Gly 100 105 110 Arg Ser Gly Lys Asn Pro Asn His Phe Arg Pro Glu Gly Leu Pro Glu 115 120 125 Lys Phe 130 < 210 > 110 < 211 > 85 < 212 > PRT < 213 > Mus musculus < 220 > < 221 > MISC _ FEATURE < 223 > MAA 1 < 400 > 110 Gly Phe Phe Ser Phe Val His Glu Ala Phe Gln Gly Ala Gly Asp Met 1 5 10 15 Trp Arg Ala Tyr Thr Asp Met Lys Glu Ala Asn Trp Lys Asn Ser His 20 25 30 Glu Asp Thr Ile Ala Asp Gln Glu Ala Asp Lys Tyr Phe His Ala Arg 35 40 45 Gly Asn Tyr Asp Ala Ala Gln Arg Gly Pro Gly Gly Val Trp Ala Ala 50 55 60 Glu Lys Ile Ser Asp Gly Arg Glu Ala Phe Gln Glu Phe Phe Gly Arg 65 70 75 80 Gly His Glu Asp Thr 85 < 210 > 111 < 211 > 75 < 212 > PRT < 213 > Mouse < 220 > < 221 > MISC _ FEATURE < 223 > MAA 2 < 400 > 111 Gly Phe Phe Ser Phe Ile Gly Glu Ala Phe Gln Gly Ala Gly Asp Met 1 5 10 15 Trp Arg Ala Tyr Thr Asp Met Lys Glu Ala Gly Trp Lys Asp Gly Asp 20 25 30 Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Gln Arg Gly Pro 35 40 45 Gly Gly Val Trp Ala Ala Glu Lys Ile Ser Asp Ala Arg Glu Ser Phe 50 55 60 Gln Glu Phe Phe Gly Arg Gly His Glu Asp Thr 65 70 75 < 210 > 112 < 211 > 68 < 212 > PRT < 213 > Mus musculus < 220 > < 221 > MISC _ FEATURE < 223 > MAA 3 < 400 > 112 Glu Ala Gly Gln Gly Ser Arg Asp Met Trp Arg Ala Tyr Ser Asp Met 1 5 10 15 Lys Lys Ala Asn Trp Lys Asn Ser Asp Lys Tyr Phe His Ala Arg Gly 20 25 30 Asn Tyr Asp Ala Ala Arg Arg Gly Pro Gly Gly Ala Trp Ala Ala Lys 35 40 45 Val Ile Ser Asp Ala Arg Glu Ala Val Gln Lys Phe Thr Gly His Gly 50 55 60 Ala Glu Asp Ser 65 < 210 > 113 < 211 > 82 < 212 > PRT < 213 > Mus musculus < 220 > < 221 > MISC _ FEATURE < 223 > MAA 4 < 400 > 113 Trp Tyr Ser Phe Phe Arg Glu Ala Val Gln Gly Thr Trp Asp Leu Trp 1 5 10 15 Arg Ala Tyr Arg Asp Asn Leu Glu Ala Asn Tyr Gln Asn Ala Asp Gln 20 25 30 Tyr Phe Tyr Ala Arg Gly Asn Tyr Glu Ala Gln Gln Arg Gly Ser Gly 35 40 45 Gly Ile Trp Ala Ala Lys Ile Ile Ser Thr Ser Arg Lys Tyr Phe Gln 50 55 60 Gly Leu Leu Asn Arg Tyr Tyr Phe Gly Ile Arg Asn His Gly Leu Glu 65 70 75 80 Thr Leu < 210 > 114 < 211 > 122 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > HSAA 1 alpha < 400 > 114 Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Gly Val 1 5 10 15 Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 20 25 30 Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 35 40 45 Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 50 55 60 Arg Gly Pro Gly Gly Val Trp Ala Ala Glu Ala Ile Ser Asp Ala Arg 65 70 75 80 Glu Asn Ile Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser Leu Ala 85 90 95 Asp Gln Ala Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His 100 105 110 Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 115 120 < 210 > 115 < 211 > 122 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > HSSA 1 beta < 400 > 115 Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Gly Val 1 5 10 15 Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 20 25 30 Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 35 40 45 Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 50 55 60 Arg Gly Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asp Ala Arg 65 70 75 80 Glu Asn Ile Gln Arg Phe Phe Gly His Asp Ala Glu Asp Ser Leu Ala 85 90 95 Asp Gln Ala Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His 100 105 110 Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 115 120 < 210 > 116 < 211 > 122 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > HSSA 1 gamma < 400 > 116 Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Gly Val 1 5 10 15 Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 20 25 30 Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 35 40 45 Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 50 55 60 Arg Gly Pro Gly Gly Val Trp Ala Ala Glu Ala Ile Ser Asp Ala Arg 65 70 75 80 Glu Asn Ile Gln Arg Phe Phe Gly His Asp Ala Glu Asp Ser Leu Ala 85 90 95 Asp Gln Ala Ala Asn Lys Trp Gly Arg Ser Gly Arg Asp Pro Asn His 100 105 110 Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 115 120 < 210 > 117 < 211 > 122 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > HSAA 2 alpha < 400 > 117 Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Ser Val 1 5 10 15 Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 20 25 30 Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 35 40 45 Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 50 55 60 Arg Gly Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asn Ala Arg 65 70 75 80 Glu Asn Ile Gln Arg Leu Thr Gly His Gly Ala Glu Asp Ser Leu Ala 85 90 95 Asp Gln Ala Ala Asn Lys Trp Gly Arg Ser Gly Arg Asp Pro Asn His 100 105 110 Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 115 120 < 210 > 118 < 211 > 122 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > HSAA 2 beta < 400 > 118 Met Lys Leu Leu Thr Gly Leu Val Phe Cys Ser Leu Val Leu Ser Val 1 5 10 15 Ser Ser Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala 20 25 30 Arg Asp Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile 35 40 45 Gly Ser Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys 50 55 60 Arg Gly Pro Gly Gly Ala Trp Ala Ala Glu Val Ile Ser Asn Ala Arg 65 70 75 80 Glu Asn Ile Gln Arg Leu Thr Gly Arg Gly Ala Glu Asp Ser Leu Ala 85 90 95 Asp Gln Ala Ala Asn Lys Trp Gly Arg Ser Gly Arg Asp Pro Asn His 100 105 110 Phe Arg Pro Ala Gly Leu Pro Glu Lys Tyr 115 120 < 210 > 119 < 211 > 104 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > HAA 1 beta isoform < 400 > 119 Arg Ser Phe Phe Ser Phe Leu Gly Glu Ala Phe Asp Gly Ala Arg Asp 1 5 10 15 Met Trp Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Ile Gly Ser 20 25 30 Asp Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Lys Arg Gly 35 40 45 Pro Gly Gly Val Trp Ala Ala Glu Ala Ile Ser Asp Ala Arg Glu Asn 50 55 60 Ile Gln Arg Phe Phe Gly His Gly Ala Glu Asp Ser Leu Ala Asp Gln 65 70 75 80 Ala Ala Asn Glu Trp Gly Arg Ser Gly Lys Asp Pro Asn His Phe Arg 85 90 95 Pro Ala Gly Leu Pro Glu Lys Tyr 100 < 210 > 120 < 211 > 102 < 212 > PRT < 213 > Mus musculus < 220 > < 221 > MISC _ FEATURE < 223 > Serum amyloid A protein < 400 > 120 Gly Phe Phe Ser Phe Ile Gly Glu Ala Phe Gln Gly Ala Gly Asp Met 1 5 10 15 Trp Arg Ala Tyr Thr Asp Met Lys Glu Ala Gly Trp Lys Asp Gly Asp 20 25 30 Lys Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Gln Arg Gly Pro 35 40 45 Gly Gly Val Trp Ala Ala Glu Lys Ile Ser Asp Ala Arg Glu Ser Gln 50 55 60 Glu Phe Phe Gly Arg Gly His Glu Asp Thr Met Ala Asp Gln Glu Ala 65 70 75 80 Asn Arg His Gly Arg Ser Gly Lys Asp Pro Asn Tyr Tyr Arg Pro Pro 85 90 95 Gly Leu Pro Ala Lys Tyr 100 < 210 > 121 < 211 > 84 < 212 > PRT < 213 > Canis lupus familiaris ( Shar pei ) < 220 > < 221 > MISC _ FEATURE < 223 > Serum amyloid A protein < 400 > 121 Trp Tyr Ser Phe Val Gly Glu Ala Ala Gln Gly Ala Trp Asp Met Leu 1 5 10 15 Arg Ala Tyr Ser Asp Met Arg Glu Ala Asn Tyr Lys Asn Ser Asp Lys 20 25 30 Tyr Phe His Ala Arg Gly Asn Tyr Asp Ala Ala Gln Arg Gly Pro Gly 35 40 45 Gly Ala Trp Ala Ala Lys Val Ile Ser Asp Ala Arg Glu Asn Ser Gln 50 55 60 Arg Asp Ser Gly His Gly Ala Glu Asp Ser Lys Ala Asp Gln Ala Ala 65 70 75 80 Asn Glu Trp Gly < 210 > 122 < 211 > 8 < 212 > PRT < 213 > Artificial < 220 > < 223 > Amino acid insert between positions 67 and 68 of Shar Pei sequence < 400 > 122 Ile Thr Asp Leu Leu Arg Phe Gly 1 5 < 210 > 123 < 211 > 95 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > kpla < 220 > < 221 > MISC _ FEATURE < 223 > Germline sequences of V kappa light chain < 400 > 123 Asp Ile Gln Met Thr Gln Ser Pro Ser Thr Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Ser Ile Ser Ser Trp 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Lys Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Asp Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr Asn Ser Tyr Ser 85 90 95 < 210 > 124 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > kplb < 220 > < 221 > MISC _ FEATURE < 223 > Germline sequences of V kappa light chain < 400 > 124 Ser Gln Asp Asn Tyr Asn Asp Asn Thr Asp Phe Glu Ile Asp Asn Leu 1 5 10 15 Pro < 210 > 125 < 211 > 11 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > kplc < 220 > < 221 > MISC _ FEATURE < 223 > Germline sequences of V kappa light chain < 400 > 125 Ser Tyr Asn Ala Gln Asp Glu Ser Tyr Thr Pro 1 5 10 < 210 > 126 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > kpld < 220 > < 221 > MISC _ FEATURE < 223 > Germline sequences of V kappa light chain < 400 > 126 Ser Gly Arg Asn Asp Gly Arg Ala Gln Glu Leu His Pro 1 5 10 < 210 > 127 < 211 > 11 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > kple < 220 > < 221 > MISC _ FEATURE < 223 > Germline sequences of V kappa light chain < 400 > 127 Ser Gly Asn Tyr Phe Ser Ala Gln Asp Glu Pro 1 5 10 < 210 > 128 < 211 > 11 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > kplf < 220 > < 221 > MISC _ FEATURE < 223 > Germline sequences of V kappa light chain < 400 > 128 Ala Leu Ser Gly Ala Asp Asp Glu Phe Asn Pro 1 5 10 < 210 > 129 < 211 > 10 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > kplg < 220 > < 221 > MISC _ FEATURE < 223 > Germline sequences of V kappa light chain < 400 > 129 Ser Val Gly Ala Gln Asp Glu Ala Phe Pro 1 5 10 < 210 > 130 < 211 > 51 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > kp 2 a < 220 > < 221 > MISC _ FEATURE < 223 > Germline sequences of V kappa light chain < 400 > 130 Val Thr Leu Ser Pro Val Thr Pro Glu Pro Ala Ser Ser Ser Leu Leu 1 5 10 15 Asp Ser Asp Asp Gly Asn Thr Tyr Asp Leu Gln Ser Gln Thr Leu Tyr 20 25 30 Arg Ala Asp Asp Lys Arg Val Glu Ala Glu Val Gly Val Met Arg Ile 35 40 45 Glu Phe Pro 50 < 210 > 131 < 211 > 49 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > kp 2 b < 220 > < 221 > MISC _ FEATURE < 223 > Germline sequences of V kappa light chain < 400 > 131 Val Leu Ser Pro Val Thr Pro Glu Pro Ala Ser Ser Ser Leu Leu His 1 5 10 15 Ser Asn Gly Tyr Asn Tyr Asp Leu Gln Ser Gln Leu Gly Asn Arg Ala 20 25 30 Asp Asp Lys Arg Val Glu Ala Glu Val Gly Val Met Ala Leu Gln Thr 35 40 45 Pro < 210 > 132 < 211 > 50 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > kp 2 c < 220 > < 221 > MISC _ FEATURE < 223 > Germline sequences of V kappa light chain < 400 > 132 Val Thr Leu Ser Val Thr Pro Gln Pro Ala Ser Ser Lys Ser Leu Leu 1 5 10 15 His Ser Asp Gly Lys Thr Tyr Tyr Leu Gln Pro Gln Glu Val Asn Arg 20 25 30 Phe Asp Asp Lys Arg Val Glu Ala Glu Val Gly Val Met Ser Ile Gln 35 40 45 Leu Pro 50 < 210 > 133 < 211 > 26 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > kp 3 a < 220 > < 221 > MISC _ FEATURE < 223 > Germline sequences of V kappa light chain < 400 > 133 Glu Val Ala Val Pro Glu Ala Leu Ser Val Asn Gln Arg Gly Thr Arg 1 5 10 15 Ala Thr Ile Ala Ser Glu Val Asn Trp Pro 20 25 < 210 > 134 < 211 > 29 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > kp 3 b < 220 > < 221 > MISC _ FEATURE < 223 > Germline sequences of V kappa light chain < 400 > 134 Glu Val Leu Gly Leu Pro Glu Ala Leu Ser Val Ser Tyr Gln Arg Gly 1 5 10 15 Arg Ala Thr Ile Asp Asp Arg Glu Glu Val Gly Ser Pro 20 25 < 210 > 135 < 211 > 31 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > kp 3 c < 220 > < 221 > MISC _ FEATURE < 223 > Germline sequences of V kappa light chain < 400 > 135 Glu Val Leu Ala Leu Pro Glu Ala Leu Ser Val Ser Tyr Gln Arg Asp 1 5 10 15 Asn Arg Ala Thr Ile Ala Asp Glu Glu Val Arg Ser Asn Trp Pro 20 25 30 < 210 > 136 < 211 > 35 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > kp 4 < 220 > < 221 > MISC _ FEATURE < 223 > Germline sequences of V lambda light chain < 400 > 136 Val Asp Ser Ala Val Leu Glu Ala Asn Lys Ser Val Leu Tyr Ser Ser 1 5 10 15 Asn Asn Lys Asn Tyr Gln Pro Trp Thr Arg Asp Asp Ala Glu Val Val 20 25 30 Tyr Thr Pro 35 < 210 > 137 < 211 > 49 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > kp 5 < 220 > < 221 > MISC _ FEATURE < 223 > V lambda light chain < 400 > 137 Glu Thr Thr Leu Ala Phe Met Thr Pro Lys Asn Ser Lys Asp Asp Asp 1 5 10 15 Asp Met Asn Glu Ala Ile Phe Ile Gln Glu Thr Thr Val Pro Ile Pro 20 25 30 Tyr Asp Asn Asn Ile Glu Ser Glu Ala Tyr Phe Leu His Asp Asn Phe 35 40 45 Pro < 210 > 138 < 211 > 97 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > lmla < 220 > < 221 > MISC _ FEATURE < 223 > V lambda light chain < 400 > 138 Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Ala Ala Pro Gly Gln 1 5 10 15 Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr 20 25 30 Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu Ile 35 40 45 Tyr Glu Asn Asn Lys Arg Pro Ser Gly Ile Pro Asp Arg Phe Ser Gly 50 55 60 Ser Lys Ser Gly Thr Ser Ala Thr Leu Gly Ile Thr Gly Leu Gln Thr 65 70 75 80 Gly Asp Glu Ala Asp Tyr Tyr Cys Gly Thr Trp Asp Ser Ser Leu Ser 85 90 95 Ala < 210 > 139 < 211 > 19 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > lmlb < 220 > < 221 > MISC _ FEATURE < 223 > V lambda light chain < 400 > 139 Ala Gly Thr Arg Ser Tyr Arg Gln Val Ser Ala Ser Arg Ser Glu Ala 1 5 10 15 Ala Asp Gly < 210 > 140 < 211 > 21 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > lmlc < 220 > < 221 > MISC _ FEATURE < 223 > V lambda light chain < 400 > 140 Val Gly Arg Thr Ala Gly Tyr Asp His Gly Ser Asn Val Ser Ala Ala 1 5 10 15 Glu Gln Ser Tyr Gly 20 < 210 > 141 < 211 > 27 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > lm 2 a < 220 > < 221 > MISC _ FEATURE < 223 > V lambda light chain < 400 > 141 Ala Ala Gly Ser Ser Ile Thr Thr Asp Val Ser Tyr Leu His Lys Met 1 5 10 15 Gly Ser Val Ser Ala Ala Glu Gln Ser Tyr Gly 20 25 < 210 > 142 < 211 > 34 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > lm 2 b < 220 > < 221 > MISC _ FEATURE < 223 > V lambda light chain < 400 > 142 Ala Arg Gly Ser Val Ile Thr Thr Asp Val Gly Tyr His Lys Met Asp 1 5 10 15 Val Ser Val Asn Thr Ser Thr Ser Ala Glu Cys Ser Tyr Ala Gly Tyr 20 25 30 Thr Phe < 210 > 143 < 211 > 41 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > lm 3 a < 220 > < 221 > MISC _ FEATURE < 223 > V lambda light chain < 400 > 143 Ser Tyr Val Lys Thr Ala Arg Thr Gly Asn Asn Ile Gly Ser Lys Ser 1 5 10 15 His Lys Gln Val Val Val Asp Asp Ser Asp Glu Asn Asn Thr Thr Ser 20 25 30 Arg Val Glu Ala Gln Val Ser Asp His 35 40 < 210 > 144 < 211 > 38 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > lm 3 b < 220 > < 221 > MISC _ FEATURE < 223 > V lambda light chain < 400 > 144 Ser Tyr Glu Val Ser Thr Ala Arg Thr Asp Ala Leu Pro Lys Gln Ala 1 5 10 15 Tyr Lys Gln Val Val Lys Asp Ser Glu Glu Ser Thr Val Thr Ser Val 20 25 30 Ala Glu Gln Ser Ala Gly 35 < 210 > 145 < 211 > 39 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > lm 3 c < 220 > < 221 > MISC _ FEATURE < 223 > V lambda light chain < 400 > 145 Ser Tyr Glu Val Ser Thr Ala Ser Thr Asp Lys Leu Gly Asp Lys Ala 1 5 10 15 Cys Lys Gln Ser Val Val Gln Asp Ser Glu Asn Asn Thr Thr Ser Thr 20 25 30 Ala Met Gln Ala Thr Ala His 35 < 210 > 146 < 211 > 23 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > lm 4 < 220 > < 221 > MISC _ FEATURE < 223 > V lambda light chain < 400 > 146 Ser Glu Asp Ala Val Leu Thr Arg Thr Gln Asp Leu Arg Ser Tyr Ala 1 5 10 15 Lys Gln Val Val Gly Lys Asn 20 < 210 > 147 < 211 > 38 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > lm 6 < 220 > < 221 > MISC _ FEATURE < 223 > V lambda light chain < 400 > 147 Asn Phe Met His Glu Ser Lys Thr Thr Arg Gly Ser Ala Ser Gln Arg 1 5 10 15 Ser Ser Thr Thr Val Asp Gln Val Ile Asp Ser Ser Asn Ser Thr Ser 20 25 30 Lys Glu Gln Ser Tyr Asn 35 < 210 > 148 < 211 > 57 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > lm 7 < 220 > < 221 > MISC _ FEATURE < 223 > V lambda light chain < 400 > 148 Thr Val Glu Leu Thr Val Ser Gly Thr Leu Thr Ala Ser Thr Gly Ala 1 5 10 15 Val Thr Ser Gly Tyr Pro Asn Phe Lys Gln Arg Ala Ser Thr Ser Asn 20 25 30 Lys His Trp Thr Ala Leu Leu Gly Lys Ala Thr Leu Ser Val Pro Glu 35 40 45 Glu Leu Leu Tyr Tyr Gly Gly Ala Gln 50 55 < 210 > 149 < 211 > 50 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > lm 8 < 220 > < 221 > MISC _ FEATURE < 223 > V lambda light chain < 400 > 149 Leu Ser Ala Ser Leu Ala Ser Lys Leu Thr Thr Leu Gly His Ser Ser 1 5 10 15 Tyr Ala Ile Ala His Gln Glu Lys Gly Arg Tyr Met Lys Leu Ser Asp 20 25 30 Gly Gly Asp Ser Ala Glu Arg Tyr Thr Ser Ser Ser Glu Gln Gly Thr 35 40 45 Gly Ile 50 < 210 > 150 < 211 > 98 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > V lambda Wil < 400 > 150 Asn Phe Leu Leu Thr Gln Pro His Ser Val Ser Glu Ser Pro Gly Lys 1 5 10 15 Thr Val Thr Ile Ser Cys Thr Arg Ser Ser Gly Ser Ile Ala Asn Asn 20 25 30 Tyr Val His Trp Tyr Gln Gln Arg Pro Gly Ser Ser Pro Thr Thr Val 35 40 45 Ile Phe Glu Asp Asp His Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 50 55 60 Gly Ser Val Asp Thr Ser Ser Asn Ser Ala Ser Leu Thr Ile Ser Gly 65 70 75 80 Leu Lys Thr Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp His 85 90 95 Asn Asn < 210 > 151 < 211 > 4 < 212 > PRT < 213 > Artificial < 220 > < 223 > AL V kappa fragment from amyloid protein < 220 > < 221 > MISC _ FEATURE < 223 > Consensus sequence derived from human amyloidogenic proteins < 400 > 151 Pro Glu Asp Val 1 < 210 > 152 < 211 > 131 < 212 > PRT < 213 > Mus musculus < 220 > < 221 > MISC _ FEATURE < 223 > Murine 2 A 4 and 8 G 9 v kappa light chain < 220 > < 221 > SIGNAL < 222 > ( 1 ) . .( 19 ) < 223 > Leader sequence < 220 > < 221 > mat _ peptide < 222 > ( 20 ) . .( 131 ) < 220 > < 221 > MISC _ FEATURE < 222 > ( 43 ) . .( 58 ) < 223 > CDR 1 < 220 > < 221 > MISC _ FEATURE < 222 > ( 74 ) . .( 80 ) < 223 > CDR 2 < 220 > < 221 > MISC _ FEATURE < 222 > ( 113 ) . .( 121 ) < 223 > CDR 3 < 400 > 152 Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala - 15 - 10 - 5 Ser Ser Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val - 1 1 5 10 Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 15 20 25 Val His Ser Thr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 30 35 40 45 Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 50 55 60 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr 65 70 75 Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 80 85 90 Ser Gln Ser Thr His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu 95 100 105 Glu Ile Lys 110 < 210 > 153 < 211 > 131 < 212 > PRT < 213 > Mus musculus < 220 > < 221 > MISC _ FEATURE < 223 > Murine 7 D 8 v kappa light chain < 220 > < 221 > SIGNAL < 222 > ( 1 ) . .( 19 ) < 223 > Leader sequence < 220 > < 221 > mat _ peptide < 222 > ( 20 ) . .( 131 ) < 220 > < 221 > MISC _ FEATURE < 222 > ( 43 ) . .( 58 ) < 223 > CDR 1 < 220 > < 221 > MISC _ FEATURE < 222 > ( 74 ) . .( 80 ) < 223 > CDR 2 < 220 > < 221 > MISC _ FEATURE < 222 > ( 113 ) . .( 121 ) < 223 > CDR 3 < 400 > 153 Met Lys Leu Pro Val Arg Leu Leu Val Leu Met Phe Trp Ile Pro Ala - 15 - 10 - 5 Ser Ser Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val - 1 1 5 10 Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Leu Ser Leu 15 20 25 Val His Ser Thr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro 30 35 40 45 Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 50 55 60 Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr 65 70 75 Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 80 85 90 Ser Gln Ser Thr His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu 95 100 105 Glu Ile Lys 110 < 210 > 154 < 211 > 138 < 212 > PRT < 213 > Mus musculus < 220 > < 221 > MISC _ FEATURE < 223 > Murine 2 A 4 , 8 G 9 and 7 D 8 v heavy chain < 220 > < 221 > SIGNAL < 222 > ( 1 ) . .( 19 ) < 223 > Leader sequence < 220 > < 221 > mat _ peptide < 222 > ( 20 ) . .( 138 ) < 220 > < 221 > MISC _ FEATURE < 222 > ( 45 ) . .( 54 ) < 223 > CDR 1 < 220 > < 221 > MISC _ FEATURE < 222 > ( 69 ) . .( 87 ) < 223 > CDR 2 < 220 > < 221 > MISC _ FEATURE < 222 > ( 120 ) . .( 127 ) < 223 > CDR 3 < 400 > 154 Met Val Leu Gly Leu Lys Trp Val Phe Phe Val Val Phe Tyr Gln Gly - 15 - 10 - 5 Val His Cys Glu Val Gln Leu Val Glu Ser Gly Gly Arg Leu Val Gln - 1 1 5 10 Pro Lys Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 15 20 25 Asn Thr Tyr Ala Met Tyr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu 30 35 40 45 Glu Trp Val Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Ile Tyr 50 55 60 Tyr Ala Asp Ser Val Lys Asp Arg Phe Thr Ile Phe Arg Asp Asp Ser 65 70 75 Gln Ser Met Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr 80 85 90 Ala Met Tyr Tyr Cys Val Arg Pro Tyr Ser Asp Ser Phe Ala Tyr Trp 95 100 105 Gly Gln Gly Thr Leu Val Thr Val Ser Ala 110 115 < 210 > 155 < 211 > 112 < 212 > PRT < 213 > Artificial < 220 > < 223 > Humanized 2 A 4 and 8 G 9 v kappa light chain version 1 < 400 > 155 Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 20 25 30 Thr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 85 90 95 Thr His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 < 210 > 156 < 211 > 112 < 212 > PRT < 213 > Artificial < 220 > < 223 > Humanized 2 A 4 and 8 G 9 v kappa light chain version 2 < 400 > 156 Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 20 25 30 Thr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 85 90 95 Thr His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 < 210 > 157 < 211 > 112 < 212 > PRT < 213 > Artificial < 220 > < 223 > Humanized 2 A 4 and 8 G 9 v kappa light chain version 3 < 400 > 157 Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 20 25 30 Thr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 85 90 95 Thr His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 < 210 > 158 < 211 > 112 < 212 > PRT < 213 > Artificial < 220 > < 223 > Humanized 7 D 8 v kappa light chain version 1 < 400 > 158 Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Leu Ser Leu Val His Ser 20 25 30 Thr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 85 90 95 Thr His Val Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 < 210 > 159 < 211 > 112 < 212 > PRT < 213 > Artificial < 220 > < 223 > Humanized 7 D 8 v kappa light chain version 2 < 400 > 159 Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Leu Ser Leu Val His Ser 20 25 30 Thr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 85 90 95 Thr His Val Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 < 210 > 160 < 211 > 112 < 212 > PRT < 213 > Artificial < 220 > < 223 > Humanized 7 D 8 v kappa light chain version 3 < 400 > 160 Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Leu Ser Leu Val His Ser 20 25 30 Thr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 85 90 95 Thr His Val Pro Phe Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 100 105 110 < 210 > 161 < 211 > 119 < 212 > PRT < 213 > Artificial < 220 > < 223 > Humanized 2 A 4 , 8 G 9 and 7 D 8 heavy chain version 1 < 400 > 161 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 20 25 30 Ala Met Tyr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Ile Tyr Tyr Ala Asp 50 55 60 Ser Val Lys Asp Arg Phe Thr Ile Phe Arg Asp Asp Ser Lys Asn Ser 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Val Arg Pro Tyr Ser Asp Ser Phe Ala Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 < 210 > 162 < 211 > 119 < 212 > PRT < 213 > Artificial < 220 > < 223 > Humanized 2 A 4 , 8 G 9 and 7 D 8 heavy chain version 2 < 400 > 162 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 20 25 30 Ala Met Tyr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Ile Tyr Tyr Ala Asp 50 55 60 Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Val Arg Pro Tyr Ser Asp Ser Phe Ala Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 < 210 > 163 < 211 > 119 < 212 > PRT < 213 > Artificial < 220 > < 223 > Humanized 2 A 4 , 7 D 8 and 8 g 9 heavy chain version 3 < 400 > 163 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 20 25 30 Ala Met Tyr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Ile Tyr Tyr Ala Asp 50 55 60 Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Pro Tyr Ser Asp Ser Phe Ala Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ser 115 < 210 > 164 < 211 > 119 < 212 > PRT < 213 > Mus musculus < 400 > 164 Glu Val Gln Leu Val Glu Ser Gly Gly Arg Leu Val Gln Pro Lys Gly 1 5 10 15 Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Thr Tyr 20 25 30 Ala Met Tyr Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Ile Tyr Tyr Ala Asp 50 55 60 Ser Val Lys Asp Arg Phe Thr Ile Phe Arg Asp Asp Ser Gln Ser Met 65 70 75 80 Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 85 90 95 Tyr Cys Val Arg Pro Tyr Ser Asp Ser Phe Ala Tyr Trp Gly Gln Gly 100 105 110 Thr Leu Val Thr Val Ser Ala 115 < 210 > 165 < 211 > 120 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > Human heavy chain framework < 400 > 165 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp His 20 25 30 Tyr Met Asp Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Gly Arg Thr Arg Asn Lys Ala Asn Ser Tyr Thr Thr Glu Tyr Ala Ala 50 55 60 Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asp Ser Lys Asn Ser 65 70 75 80 Leu Tyr Leu Gln Met Asn Ser Leu Lys Thr Glu Asp Thr Ala Val Tyr 85 90 95 Tyr Cys Ala Arg Tyr Val Val Gly Ala Thr Leu Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 < 210 > 166 < 211 > 113 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MISC _ FEATURE < 223 > Human v kappa light chain framework < 400 > 166 Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 20 25 30 Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn Arg Ala Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Ala 85 90 95 Leu Gln Thr Pro Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 110 Arg < 210 > 167 < 211 > 276 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > misc _ feature < 223 > Human v kappa light chain framework < 400 > 167 Met Lys Tyr Leu Leu Pro Thr Ala Ala Ala Gly Leu Leu Leu Leu Ala 1 5 10 15 Ala Gln Pro Ala Met Ala Asp Val Val Met Thr Gln Ser Pro Leu Ser 20 25 30 Leu Pro Val Thr Pro Gly Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser 35 40 45 Gln Ser Leu Leu His Ser Asn Gly Tyr Asn Tyr Leu Asp Trp Tyr Leu 50 55 60 Gln Lys Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Leu Gly Ser Asn 65 70 75 80 Arg Ala Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 85 90 95 Asp Phe Thr Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val 100 105 110 Tyr Tyr Cys Met Gln Ala Leu Gln Thr Pro Tyr Thr Phe Gly Gln Gly 115 120 125 Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 130 135 140 Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 145 150 155 160 Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 165 170 175 Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu 180 185 190 Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu 195 200 205 Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr 210 215 220 His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu 225 230 235 240 Cys Ser Ala Arg Gln Ser Thr Pro Phe Val Cys Glu Tyr Gln Gly Gln 245 250 255 Ser Ser Asp Leu Pro Gln Pro Pro Val Asn Ala Gly Gly Gly Ser Gly 260 265 270 Gly Gly Ser Gly 275 < 210 > 168 < 211 > 16 < 212 > PRT < 213 > Mus musculus < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 16 ) < 223 > 2 A 4 VL CDR 1 < 400 > 168 Arg Ser Ser Gln Ser Leu Val His Ser Thr Gly Asn Thr Tyr Leu His 1 5 10 15 < 210 > 169 < 211 > 7 < 212 > PRT < 213 > Mus musculus < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 7 ) < 223 > 2 A 4 VL CDR 2 < 400 > 169 Lys Val Ser Asn Arg Phe Ser 1 5 < 210 > 170 < 211 > 9 < 212 > PRT < 213 > Mus musculus < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 9 ) < 223 > 2 A 4 VL CDR 3 < 400 > 170 Ser Gln Ser Thr His Val Pro Phe Thr 1 5 < 210 > 171 < 211 > 10 < 212 > PRT < 213 > Mus musculus < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 10 ) < 223 > 2 A 4 VH CDR 1 < 400 > 171 Gly Phe Thr Phe Asn Thr Tyr Ala Met Tyr 1 5 10 < 210 > 172 < 211 > 19 < 212 > PRT < 213 > Mus musculus < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 19 ) < 223 > 2 A 4 VH CDR 2 < 400 > 172 Arg Ile Arg Ser Lys Ser Asn Asn Tyr Ala Ile Tyr Tyr Ala Asp Ser 1 5 10 15 Val Lys Asp < 210 > 173 < 211 > 8 < 212 > PRT < 213 > Mus musculus < 220 > < 221 > MISC _ FEATURE < 222 > ( 1 ) . .( 8 ) < 223 > 2 A 4 VH CDR 3 < 400 > 173 Pro Tyr Ser Asp Ser Phe Ala Tyr 1 5 < 210 > 174 < 211 > 112 < 212 > PRT < 213 > Artificial < 220 > < 223 > Humanized 7 D 8 v kappa light chain version 4 < 400 > 174 Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Leu Ser Leu Val His Ser 20 25 30 Thr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Tyr Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 85 90 95 Thr His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 < 210 > 175 < 211 > 112 < 212 > PRT < 213 > Artificial < 220 > < 223 > Humanized 7 D 8 v kappa light chain version 5 < 400 > 175 Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Leu Ser Leu Val His Ser 20 25 30 Thr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Phe Cys Ser Gln Ser 85 90 95 Thr His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 < 210 > 176 < 211 > 112 < 212 > PRT < 213 > Artificial < 220 > < 223 > Humanized 7 D 8 v kappa light chain version 6 < 400 > 176 Asp Val Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 1 5 10 15 Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Leu Ser Leu Val His Ser 20 25 30 Thr Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 35 40 45 Pro Gln Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 50 55 60 Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 65 70 75 80 Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 85 90 95 Thr His Val Pro Phe Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 100 105 110 < 210 > 177 < 211 > 16 < 212 > PRT < 213 > Mus musculus < 400 > 177 Arg Ser Ser Leu Ser Leu Val His Ser Thr Gly Asn Thr Tyr Leu His 1 5 10 15