1 H NMR ( 400 MHz , CD 3 OD ) δ 9 . 12 ( br s , 1 H ) , 8 . 92 ( s , 1 H ) , 8 . 82 - 8 . 74 ( br s , 1 H ) , 8 . 47 ( br s , 1 H ) , 8 . 18 ( d , J = 8 . 5 Hz , 1 H ) , 7 . 74 ( dd , J = 9 . 0 , 2 . 0 Hz , 1 H ) , 6 . 50 ( s , 1 H ) , 5 . 57 - 5 . 46 ( m , 1 H ) , 4 . 21 ( dd , J = 11 . 8 , 4 . 8 Hz , 1 H ) , 3 . 82 - 3 . 70 ( br m , 1 H ) , 3 . 62 - 3 . 47 ( br m , 1 H ) , 2 . 71 - 2 . 57 ( br m , 1 H ) , 2 . 59 ( s , 3 H ) , 2 . 48 - 2 . 35 ( m , 1 H ) , 2 . 24 - 2 . 13 ( br m , 1 H ) , 1 . 63 - 1 . 50 ( br m , 1 H ) , 1 . 34 ( d , J = 6 . 0 Hz , 3 H ) .