Hello Sir , glad you came back . 1 To the best of my knowledge , there are no extra issues with birth it ' s something I ' ve never heard mentioned . However , in the days after birth there may be a bowel blockage this is how I was diagnosed , btw . From your early fathering days , you may dimly remember the first time a baby empties its bowels of the thick sludgy meconium . Well , a lot of things in CF comes down to substances being thicker than they should be , and the meconium is just another one of these things . If you have a prebirth diagnosis , this blockage will be anticipated and is not 100 % certain to happen . 2 I am not entirely sure , as obviously I can ' t remember . You will have read that CFers lack the enzymes to digest food , but I think breast milk contains enzymes so can be digested . Your son will be taught how to do physiotherapy on your grandaughter it is fairly straightforward should he want you to learn it . 3 A sibling will cause little to no issues at all . In fact , the only thing to worry about is that Big Brother may get a little put out that Little Sister is getting even more attention than a normal younger sibling would . You may need to step in to distract him , or take him out for the day if his sister is ill or needs to visit hospital . Don ' t worry about Big Brother passing on infections they are impossible to avoid , and Little Sister will catch them from someone at sometime , and you can drive yourself mad trying to fend them off . 4 Only you know how much your son will want your help , be it practical or emotional . If your own health and lifestyle allow , make the offer to help in whatever way you can , and let him decide . Do you live close to them ? If you do , you might be able to help pick up medications , or babysit Big Brother . However , your son may want to handle as much of it himself as he can . What you will see on this sub time and time again is the importance of exercise in keeping the lungs clear . So , later on in her life , don ' t be the Grandad who buys her a games console which keeps her stuck indoors all the time . If she is staying with you and wants to run around the park , sorry Gramps , but no quietly reading the paper by the fire for you . I wish you and your family all the best . This will become your new normal , and all of you will adapt . There is a good range of people on this sub with lots of different experiences , so ask away again if you need to .