So I know you said that the rumors were false , but are they false ? <| sep |> they ' re more juvenile than I rememberExplains Rihanna . <| sep |> To piggy back off your chemical imbalance factor and how individuals have a variety of unique factors that affect medication efficiency and absorption , i for one can 100 % confirm this from a semi recent personal experience ! ! pH affects how your body metabolizes the medication , and that ' s only one example of how body chemistry can affect medication effectiveness and require dosage adjustments wanna know something else that ' s super common that happens to roughly half of the population that causes constant fluctuations in a persons biochemistry on a frequent and regular basis ? ! MENSTRUATION ! ! YUPP ! If you ' re a female with ADHD , you ' ve probably noticed a difference in how well your meds work during different times in your cycle . Pretty much the week before my period , and the week of my period , my medication might as well have been a placebo sugar pill because it did NOTHING . When I ' m in the week around the time of ovulation is when my medication is working at its best . Took me 4 years to make that connection and when I finally asked my male doctor about it saying how I noticed during my period and right before it , my meds barely work and wondered if that was something that could possibly have an effect on my medicine and he was like actually yes , it most definitely can influence medication effectiveness and you could tell by his face that it was a kinda light bulb moment for him like an internal crap totally forgot about menstrual cycles being a thing and women ' s body chemistry actually changes periodically . We had a good laugh about it and he suggested taking an extra slightly increased dosage when I ' m about to start and on my period .