SEQUENCE LISTING < 110 > Ma , Jianjie < 120 > Compositions and Methods of Modulating Cell Membrane Resealing < 130 > 115442 . 00008 < 140 > TBD < 141 > 2008 - 12 - 02 < 150 > 60 / 005 , 410 < 151 > 2007 - 12 - 04 < 160 > 16 < 170 > PatentIn version 3 . 5 < 210 > 1 < 211 > 477 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 477 ) < 223 > Human MG 53 Polypeptide < 400 > 1 Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 1 5 10 15 Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 20 25 30 Phe Cys Arg Ala Cys Leu Gly Arg Val Ala Gly Glu Pro Ala Ala Asp 35 40 45 Gly Thr Val Leu Cys Pro Cys Cys Gln Ala Pro Thr Arg Pro Gln Ala 50 55 60 Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 65 70 75 80 Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 85 90 95 Cys Glu Gln Asp Arg Ala Leu Val Cys Gly Val Cys Ala Ser Leu Gly 100 105 110 Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 115 120 125 Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Cys 130 135 140 Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Val Glu 145 150 155 160 Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 165 170 175 Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Cys 180 185 190 Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 195 200 205 Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 210 215 220 Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 225 230 235 240 Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ser Pro 245 250 255 Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp Asp Phe 260 265 270 Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Ala Leu 275 280 285 Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 290 295 300 Ser Ser Ser Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 305 310 315 320 Ala Gly Glu Asp Pro Arg Gln Phe Asp Lys Ala Val Ala Val Val Ala 325 330 335 His Gln Gln Leu Ser Glu Gly Glu His Tyr Trp Glu Val Asp Val Gly 340 345 350 Asp Lys Pro Arg Trp Ala Leu Gly Val Ile Ala Ala Glu Ala Pro Arg 355 360 365 Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 370 375 380 Leu Arg Glu Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 385 390 395 400 Arg Ala Leu Arg Ser Pro Glu Arg Arg Pro Thr Arg Ile Gly Leu Tyr 405 410 415 Leu Ser Phe Gly Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Ala 420 425 430 Asp Ala Leu Val Pro Leu Phe Ala Phe His Glu Arg Leu Pro Arg Pro 435 440 445 Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 450 455 460 Gln Pro Leu Leu Leu Val Gly Pro Glu Gly Ala Glu Ala 465 470 475 < 210 > 2 < 211 > 1434 < 212 > DNA < 213 > Homo sapiens < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 1434 ) < 223 > Human MG 53 cDNA < 400 > 2 atgtcggctg cgcccggcct cctgcaccag gagctgtcct gcccgctgtg cctgcagctg 60 ttcgacgcgc ccgtgacagc cgagtgcggc cacagtttct gccgcgcctg cctaggccgc 120 gtggccgggg agccggcggc ggatggcacc gttctctgcc cctgctgcca ggcccccacg 180 cggccgcagg cactcagcac caacctgcag ctggcgcgcc tggtggaggg gctggcccag 240 gtgccgcagg gccactgcga ggagcacctg gacccgctga gcatctactg cgagcaggac 300 cgcgcgctgg tgtgcggagt gtgcgcctca ctcggctcgc accgcggtca tcgcctcctg 360 cctgccgccg aggcccacgc acgcctcaag acacagctgc cacagcagaa actgcagctg 420 caggaggcat gcatgcgtaa ggagaagagt gtggctgtgc tggagcatca gctggtggag 480 gtggaggaga cagtgcgtca gttccggggg gccgtggggg agcagctggg caagatgcgg 540 gtgttcctgg ctgcactgga gggctccttg gactgcgagg cagagcgtgt acggggtgag 600 gcaggggtcg ccttgcgccg ggagctgggg agcctgaact cttacctgga gcagctgcgg 660 cagatggaga aggtcctgga ggaggtggcg gacaagccgc agactgagtt cctcatgaaa 720 tactgcctgg tgaccagcag gctgcagaag atcctggcag agtctccccc acccgcccgt 780 ctggacatcc agctgccaat tatctcagat gacttcaaat tccaggtgtg gaggaagatg 840 ttccgggctc tgatgccagc gctggaggag ctgacctttg acccgagctc tgcgcacccg 900 agcctggtgg tgtcttcctc tggccgccgc gtggagtgct cggagcagaa ggcgccgccg 960 gccggggagg acccgcgcca gttcgacaag gcggtggcgg tggtggcgca ccagcagctc 1020 tccgagggcg agcactactg ggaggtggat gttggcgaca agccgcgctg ggcgctgggc 1080 gtgatcgcgg ccgaggcccc ccgccgcggg cgcctgcacg cggtgccctc gcagggcctg 1140 tggctgctgg ggctgcgcga gggcaagatc ctggaggcac acgtggaggc caaggagccg 1200 cgcgctctgc gcagccccga gaggcggccc acgcgcattg gcctttacct gagcttcggc 1260 gacggcgtcc tctccttcta cgatgccagc gacgccgacg cgctcgtgcc gctttttgcc 1320 ttccacgagc gcctgcccag gcccgtgtac cccttcttcg acgtgtgctg gcacgacaag 1380 ggcaagaatg cccagccgct gctgctcgtg ggtcccgaag gcgccgaggc ctga 1434 < 210 > 3 < 211 > 477 < 212 > PRT < 213 > Mus musculus < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 477 ) < 223 > Mouse MG 53 < 400 > 3 Met Ser Ala Ala Pro Gly Leu Leu Arg Gln Glu Leu Ser Cys Pro Leu 1 5 10 15 Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 20 25 30 Phe Cys Arg Ala Cys Leu Ile Arg Val Ala Gly Glu Pro Ala Ala Asp 35 40 45 Gly Thr Val Ala Cys Pro Cys Cys Gln Ala Pro Thr Arg Pro Gln Ala 50 55 60 Leu Ser Thr Asn Leu Gln Leu Ser Arg Leu Val Glu Gly Leu Ala Gln 65 70 75 80 Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 85 90 95 Cys Glu Gln Asp Arg Thr Leu Val Cys Gly Val Cys Ala Ser Leu Gly 100 105 110 Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala Gln Ala Arg 115 120 125 Leu Lys Thr Gln Leu Pro Gln Gln Lys Met Gln Leu Gln Glu Ala Cys 130 135 140 Met Arg Lys Glu Lys Thr Val Ala Val Leu Glu His Gln Leu Val Glu 145 150 155 160 Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 165 170 175 Gly Lys Met Arg Met Phe Leu Ala Ala Leu Glu Ser Ser Leu Asp Arg 180 185 190 Glu Ala Glu Arg Val Arg Gly Asp Ala Gly Val Ala Leu Arg Arg Glu 195 200 205 Leu Ser Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 210 215 220 Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 225 230 235 240 Phe Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ser Glu Ser Pro 245 250 255 Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Val Ile Ser Asp Asp Phe 260 265 270 Lys Phe Gln Val Trp Lys Lys Met Phe Arg Ala Leu Met Pro Ala Leu 275 280 285 Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 290 295 300 Ser Ser Ser Gly Arg Arg Val Glu Cys Ser Asp Gln Lys Ala Pro Pro 305 310 315 320 Ala Gly Glu Asp Thr Arg Gln Phe Asp Lys Ala Val Ala Val Val Ala 325 330 335 Gln Gln Leu Leu Ser Gln Gly Glu His Tyr Trp Glu Val Glu Val Gly 340 345 350 Asp Lys Pro Arg Trp Ala Leu Gly Val Met Ala Ala Asp Ala Ser Arg 355 360 365 Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 370 375 380 Leu Arg Asp Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 385 390 395 400 Arg Ala Leu Arg Thr Pro Glu Arg Pro Pro Ala Arg Ile Gly Leu Tyr 405 410 415 Leu Ser Phe Ala Asp Gly Val Leu Ala Phe Tyr Asp Ala Ser Asn Pro 420 425 430 Asp Val Leu Thr Pro Ile Phe Ser Phe His Glu Arg Leu Pro Gly Pro 435 440 445 Val Tyr Pro Ile Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 450 455 460 Gln Pro Leu Leu Leu Val Gly Pro Glu Gln Glu Gln Ala 465 470 475 < 210 > 4 < 211 > 1434 < 212 > DNA < 213 > Mus musculus < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 1434 ) < 223 > Mouse MG 53 cDNA < 400 > 4 atgtcggctg cacccggcct tctgcgtcag gaactgtcct gcccactgtg cttgcagctg 60 ttcgatgcgc cagtgacggc tgagtgtggc cacagtttct gccgtgcctg cctgatccgg 120 gtggcagggg agcctgctgc ggacggcaca gttgcctgtc cctgttgtca ggcacctaca 180 cggccgcagg ctctaagcac taacctccag ttgtcacgcc ttgtggaggg tttggcgcaa 240 gtgccccaag gccactgcga ggaacacctg gatccactga gcatctactg cgagcaggac 300 cgcacacttg tgtgtggtgt gtgtgcctcg ctcggttctc accgtggtca tcgtctcctg 360 cctgccgctg aagcccaagc acgcctcaag acacagcttc cacagcagaa gatgcagctg 420 caggaggcat gcatgcgcaa ggagaagact gtagcggtgc tggagcatca gctggtggag 480 gtggaggaga cagtgcgcca gttccgggga gctgtcgggg agcagctggg gaagatgcgg 540 atgttcctgg ctgccctaga aagttctctg gaccgtgaag cagaaagggt tcggggtgat 600 gctggggttg ccttgcgtcg ggagctgtca agcctgaact cttacctaga gcaactgagg 660 cagatggaga aggtgctgga ggaggtggct gacaagccac agacagaatt cctcatgaaa 720 ttctgcctgg taaccagcag gctgcagaag atcctgtcag agtcaccacc accggcaagg 780 ctagatatcc agctgcctgt catctcagat gacttcaaat tccaggtgtg gaagaagatg 840 ttccgggctc tgatgccagc gctggaggaa ctgacttttg accccagctc tgcgcacccg 900 agcctggtgg tgtcctcctc tggtcgccga gtggagtgct cagaccagaa ggcgccgcca 960 gcgggagaag acacgcgtca gttcgacaag gcagtagcgg tggtggcgca gcagctgctg 1020 tcacagggcg agcactattg ggaggtggag gtgggcgaca aaccacgctg ggccctggga 1080 gtgatggcgg ctgacgcttc ccgccgtggc cggctgcacg cggtgccctc acaggggctg 1140 tggctgctgg gtctgcgcga tggcaagatc ctggaggcgc acgtggaggc caaggagccg 1200 cgggcactgc gcaccccaga gaggcctccg gcgcgcattg gcctctacct aagcttcgca 1260 gatggcgtcc tggctttcta tgatgcgagc aaccccgacg tacttacgcc aatcttttct 1320 ttccacgagc gtctgcccgg gccggtgtac cccatctttg acgtgtgctg gcacgacaag 1380 ggcaagaatg cccagcccct gctgcttgtg gggccggagc aggaacaggc ctga 1434 < 210 > 5 < 211 > 477 < 212 > PRT < 213 > Oryctolagus cuniculus < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 477 ) < 223 > Rabbit MG 53 < 400 > 5 Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 1 5 10 15 Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 20 25 30 Phe Cys Arg Ala Cys Leu Ser Arg Val Ala Gly Glu Pro Ala Ala Asp 35 40 45 Gly Thr Val Asn Cys Pro Cys Cys Gln Ala Pro Thr Arg Pro Gln Ala 50 55 60 Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 65 70 75 80 Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 85 90 95 Cys Glu Gln Asp Arg Val Leu Val Cys Gly Val Cys Ala Ser Leu Gly 100 105 110 Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ser Arg 115 120 125 Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Ser 130 135 140 Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Thr Glu 145 150 155 160 Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 165 170 175 Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Arg 180 185 190 Glu Ala Glu Arg Val Arg Ser Glu Ala Gly Val Ala Leu Arg Arg Glu 195 200 205 Leu Gly Gly Leu His Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 210 215 220 Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 225 230 235 240 Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ser Pro 245 250 255 Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp Asp Phe 260 265 270 Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Ala Leu 275 280 285 Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 290 295 300 Ser Pro Thr Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 305 310 315 320 Ala Gly Asp Asp Ala Arg Gln Phe Asp Lys Ala Val Ala Val Val Ala 325 330 335 Gln Gln Leu Leu Ser Asp Gly Glu His Tyr Trp Glu Val Glu Val Gly 340 345 350 Asp Lys Pro Arg Trp Ala Leu Gly Val Met Ala Ser Glu Ala Ser Arg 355 360 365 Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 370 375 380 Leu Arg Asp Gly Lys Thr Leu Glu Ala His Val Glu Ala Lys Glu Pro 385 390 395 400 Arg Ala Leu Arg Thr Pro Glu Arg Arg Pro Thr Arg Leu Gly Leu Tyr 405 410 415 Leu Ser Phe Gly Asp Gly Val Leu Ala Phe Tyr Asp Ala Ser Asp Ala 420 425 430 Asp Ala Leu Glu Leu Leu Phe Ala Phe Arg Glu Arg Leu Pro Gly Pro 435 440 445 Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 450 455 460 Gln Pro Leu Leu Leu Val Gly Pro Asp Gly Gln Glu Ala 465 470 475 < 210 > 6 < 211 > 1434 < 212 > DNA < 213 > Oryctolagus cuniculus < 220 > < 221 > misc _ feature < 222 > ( 1 ) . .( 1434 ) < 223 > Rabbit MG 53 cDNA < 400 > 6 atgtcggccg cgcccggcct cctgcaccag gagctgtctt gcccgctgtg cctgcagctg 60 ttcgacgcgc ccgtgacagc cgagtgcggc cacagtttct gccgcgcctg cctgagccgc 120 gtggcggggg agccggcggc cgatggcacc gtgaactgcc cgtgctgcca ggcgcccacg 180 cggccgcagg cgctcagcac caacctgcag ctggcgcgcc tggtggaggg gctggcgcag 240 gtgccgcagg gccactgcga ggagcacctg gacccgctga gcatctactg cgagcaggac 300 cgcgttctcg tgtgcggcgt gtgcgcctcg ctcggctcgc accgcggcca ccgcctgctg 360 cccgccgccg aggcccactc gcgtctcaag acgcagctgc cccagcagaa gctgcagctg 420 caggaggcga gcatgcgcaa ggagaagagc gtggccgtgc tggagcacca gctcacggag 480 gtggaggaga cagtgcgtca gttccggggg gcagtggggg agcagctggg caagatgcgg 540 gtgttcctgg ccgccctgga gggctccctg gaccgcgagg cagaacgtgt gcggagcgag 600 gcgggggtgg ccttgcggcg ggagctgggg ggcctccact cgtacctgga gcagctgcgg 660 cagatggaga aggtgttgga ggaggtggct gacaagccac agaccgagtt ccttatgaaa 720 tattgcctgg tgaccagcag gctgcagaag atcctggcgg agtcgccacc acctgctcgt 780 ctggacatcc agctgcccat catttcagat gacttcaaat tccaggtgtg gaggaagatg 840 ttccgggctc tgatgccagc gctggaggag ctgacctttg acccgagctc cgcgcacccg 900 agcctcgtgg tgtcacccac gggccgccga gtggagtgct cggagcagaa ggcgccgccc 960 gccggggacg acgcgcgcca gttcgacaag gctgtggccg tggtggcgca gcagctgctg 1020 tccgacggcg agcactactg ggaggtggag gtgggcgaca agccgcgctg ggcgctgggc 1080 gtgatggcct ccgaggcgag ccgccgtggc cggctgcacg ccgtgccctc acagggtttg 1140 tggctgctgg ggctgcgcga cggcaagacc ctggaggcgc acgtggaggc caaggagccg 1200 cgcgcgctgc gcaccccgga gcggcggccc acgcgcctcg gcctctacct cagcttcggc 1260 gatggcgtgc tcgccttcta cgacgccagc gacgccgacg cgctcgagct gctgtttgct 1320 ttccgcgagc gcctgcccgg gcccgtgtac cccttcttcg acgtgtgctg gcatgacaag 1380 ggcaagaatg cgcagccgct gctgctcgtg gggccggatg gccaggaggc ctga 1434 < 210 > 7 < 211 > 477 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MUTAGEN < 222 > ( 29 ) . .( 29 ) < 223 > C 29 L / C 242 A < 220 > < 221 > MUTAGEN < 222 > ( 242 ) . .( 242 ) < 223 > C 29 L / C 242 A < 400 > 7 Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 1 5 10 15 Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Leu Gly His Ser 20 25 30 Phe Cys Arg Ala Cys Leu Gly Arg Val Ala Gly Glu Pro Ala Ala Asp 35 40 45 Gly Thr Val Leu Cys Pro Cys Cys Gln Ala Pro Thr Arg Pro Gln Ala 50 55 60 Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 65 70 75 80 Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 85 90 95 Cys Glu Gln Asp Arg Ala Leu Val Cys Gly Val Cys Ala Ser Leu Gly 100 105 110 Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 115 120 125 Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Cys 130 135 140 Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Val Glu 145 150 155 160 Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 165 170 175 Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Cys 180 185 190 Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 195 200 205 Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 210 215 220 Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 225 230 235 240 Tyr Ala Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ser Pro 245 250 255 Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp Asp Phe 260 265 270 Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Ala Leu 275 280 285 Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 290 295 300 Ser Ser Ser Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 305 310 315 320 Ala Gly Glu Asp Pro Arg Gln Phe Asp Lys Ala Val Ala Val Val Ala 325 330 335 His Gln Gln Leu Ser Glu Gly Glu His Tyr Trp Glu Val Asp Val Gly 340 345 350 Asp Lys Pro Arg Trp Ala Leu Gly Val Ile Ala Ala Glu Ala Pro Arg 355 360 365 Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 370 375 380 Leu Arg Glu Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 385 390 395 400 Arg Ala Leu Arg Ser Pro Glu Arg Arg Pro Thr Arg Ile Gly Leu Tyr 405 410 415 Leu Ser Phe Gly Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Ala 420 425 430 Asp Ala Leu Val Pro Leu Phe Ala Phe His Glu Arg Leu Pro Arg Pro 435 440 445 Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 450 455 460 Gln Pro Leu Leu Leu Val Gly Pro Glu Gly Ala Glu Ala 465 470 475 < 210 > 8 < 211 > 477 < 212 > PRT < 213 > Didelphis sp . < 220 > < 221 > PEPTIDE < 222 > ( 1 ) . .( 477 ) < 223 > Opossum MG 53 < 400 > 8 Met Ser Gly Ala Pro Ala Leu Met Gln Gly Met Tyr Gln Asp Leu Ser 1 5 10 15 Cys Pro Leu Cys Leu Lys Leu Phe Asp Ala Pro Ile Thr Ala Glu Cys 20 25 30 Gly His Ser Phe Cys Arg Asn Cys Leu Leu Arg Leu Ala Pro Asp Pro 35 40 45 Gln Ala Gly Thr Val Leu Cys Pro Ser Cys Gln Ala Pro Thr Lys Pro 50 55 60 Asp Gly Leu Asn Thr Asn Gln Gln Leu Ala Arg Leu Val Glu Ser Leu 65 70 75 80 Ala Gln Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser 85 90 95 Val Tyr Cys Glu Gln Asp Arg Ala Leu Ile Cys Gly Val Cys Ala Ser 100 105 110 Leu Gly Lys His Arg Gly His Ser Val Val Thr Ala Ala Glu Ala His 115 120 125 Gln Arg Met Lys Lys Gln Leu Pro Gln Gln Arg Leu Gln Leu Gln Glu 130 135 140 Ala Cys Met Arg Lys Glu Lys Thr Val Ala Leu Leu Asp Arg Gln Leu 145 150 155 160 Ala Glu Val Glu Glu Thr Val Arg Gln Phe Gln Arg Ala Val Gly Glu 165 170 175 Gln Leu Gly Val Met Arg Ala Phe Leu Ala Ala Leu Glu Ser Ser Leu 180 185 190 Gly Lys Glu Ala Glu Arg Val Thr Gly Glu Ala Gly Thr Ala Leu Lys 195 200 205 Ala Glu Arg Arg Ile Val Thr Ser Tyr Leu Asp Gln Leu Gln Gln Met 210 215 220 Glu Lys Val Leu Asp Glu Val Thr Asp Gln Pro Gln Thr Glu Phe Leu 225 230 235 240 Arg Lys Tyr Cys Leu Val Ile Ser Arg Leu Gln Lys Ile Leu Ala Glu 245 250 255 Ser Pro Pro Ala Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp 260 265 270 Asp Phe Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro 275 280 285 Gly Met Glu Val Leu Thr Phe Asp Pro Ala Ser Ala His Pro Ser Leu 290 295 300 Leu Val Ser Pro Ser Gly Arg Arg Val Glu Cys Val Glu Gln Lys Ala 305 310 315 320 Pro Pro Ala Gly Asp Asp Pro Gln Gln Phe Asp Lys Ala Val Ala Leu 325 330 335 Val Ala Lys Gln Gln Leu Ser Glu Gly Glu His Tyr Trp Glu Val Glu 340 345 350 Val Gly Asp Lys Pro Arg Trp Gly Leu Gly Leu Ile Ser Ala Asp Val 355 360 365 Ser Arg Arg Gly Lys Leu His Pro Thr Pro Ser Gln Gly Phe Trp Met 370 375 380 Leu Gly Leu Arg Glu Gly Lys Val Tyr Glu Ala His Val Glu Ser Lys 385 390 395 400 Glu Pro Lys Val Leu Lys Val Asp Gly Arg Pro Ser Arg Ile Gly Leu 405 410 415 Tyr Leu Ser Phe Arg Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp 420 425 430 Leu Asp Asn Leu Leu Pro Leu Tyr Ala Phe His Glu Arg Leu Pro Gly 435 440 445 Pro Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn 450 455 460 Ala Gln Pro Leu Leu Leu Leu Gly Pro Asp Gly Glu Gln 465 470 475 < 210 > 9 < 211 > 477 < 212 > PRT < 213 > Canis sp . < 220 > < 221 > PEPTIDE < 222 > ( 1 ) . .( 477 ) < 223 > Dog MG 53 < 400 > 9 Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 1 5 10 15 Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 20 25 30 Phe Cys Arg Ala Cys Leu Ser Arg Val Ala Gly Glu Pro Ala Ala Asp 35 40 45 Gly Thr Val Pro Cys Pro Cys Cys Gln Ala Leu Thr Arg Pro Gln Ala 50 55 60 Leu Ser Thr Asn Gln Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 65 70 75 80 Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 85 90 95 Cys Glu Gln Asp Arg Ala Leu Val Cys Gly Val Cys Ala Ser Leu Gly 100 105 110 Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 115 120 125 Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Cys 130 135 140 Met Arg Lys Glu Lys Ser Val Ala Leu Leu Glu His Gln Leu Met Glu 145 150 155 160 Val Glu Glu Met Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 165 170 175 Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Arg 180 185 190 Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 195 200 205 Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 210 215 220 Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 225 230 235 240 Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ser Pro 245 250 255 Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Val Ile Ser Asp Asp Phe 260 265 270 Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Val Thr 275 280 285 Lys Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Leu 290 295 300 Ser Pro Ser Gly Arg Arg Val Glu Cys Ser Asp Gln Lys Ala Pro Pro 305 310 315 320 Ala Gly Glu Asp Pro Cys Gln Phe Asp Lys Ala Val Ala Val Val Ala 325 330 335 Gln Gln Val Leu Ser Asp Gly Glu His Tyr Trp Glu Val Gln Val Gly 340 345 350 Glu Lys Pro Arg Trp Ala Leu Gly Val Ile Ala Ala Gln Ala Ser Arg 355 360 365 Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 370 375 380 Leu Arg Asp Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 385 390 395 400 Arg Ala Leu Arg Thr Pro Glu Arg Arg Pro Thr Arg Ile Gly Ile Tyr 405 410 415 Leu Ser Phe Gly Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Pro 420 425 430 Asp Ala Leu Glu Leu Leu Phe Ala Phe His Glu Arg Leu Pro Gly Pro 435 440 445 Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 450 455 460 Gln Pro Leu Leu Leu Val Gly Pro Asp Gly Glu Glu Ala 465 470 475 < 210 > 10 < 211 > 477 < 212 > PRT < 213 > Pan troglodytes < 220 > < 221 > PEPTIDE < 222 > ( 1 ) . .( 477 ) < 223 > Chimpanzee MG 53 < 400 > 10 Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 1 5 10 15 Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 20 25 30 Phe Cys Arg Ala Cys Leu Gly Arg Val Ala Gly Glu Pro Ala Ala Asp 35 40 45 Gly Thr Val Leu Cys Pro Cys Cys Gln Ala Pro Thr Arg Pro Gln Ala 50 55 60 Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 65 70 75 80 Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 85 90 95 Cys Glu Gln Asp Arg Ala Leu Val Cys Gly Val Cys Ala Ser Leu Gly 100 105 110 Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 115 120 125 Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Cys 130 135 140 Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Val Glu 145 150 155 160 Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 165 170 175 Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Arg 180 185 190 Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 195 200 205 Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 210 215 220 Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 225 230 235 240 Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ser Pro 245 250 255 Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp Asp Phe 260 265 270 Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Ala Leu 275 280 285 Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 290 295 300 Ser Ser Ser Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 305 310 315 320 Ala Gly Glu Asp Pro Arg Gln Phe Asp Lys Ala Val Ala Val Val Ala 325 330 335 His Gln Gln Leu Ser Glu Gly Glu His Tyr Trp Glu Val Asp Val Gly 340 345 350 Asp Lys Pro Arg Trp Ala Leu Gly Val Ile Ala Ala Glu Ala Pro Arg 355 360 365 Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 370 375 380 Leu Arg Glu Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 385 390 395 400 Arg Ala Leu Arg Ser Pro Glu Arg Arg Pro Thr Arg Ile Gly Leu Tyr 405 410 415 Leu Ser Phe Gly Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Ala 420 425 430 Asp Ala Leu Val Pro Leu Phe Ala Phe His Glu Arg Leu Pro Arg Pro 435 440 445 Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 450 455 460 Gln Pro Leu Leu Leu Val Gly Pro Glu Gly Ala Glu Ala 465 470 475 < 210 > 11 < 211 > 477 < 212 > PRT < 213 > Macaca mulatta < 220 > < 221 > PEPTIDE < 222 > ( 1 ) . .( 477 ) < 223 > Rhesus Monkey MG 53 < 400 > 11 Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 1 5 10 15 Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 20 25 30 Phe Cys Arg Ala Cys Leu Gly Arg Val Ala Gly Glu Pro Ala Ala Asp 35 40 45 Gly Thr Val Leu Cys Pro Cys Cys Gln Ala Pro Thr Arg Pro Gln Ala 50 55 60 Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 65 70 75 80 Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 85 90 95 Cys Glu Gln Asp Arg Ala Leu Val Cys Gly Val Cys Ala Ser Leu Gly 100 105 110 Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 115 120 125 Leu Lys Thr Gln Leu Pro Gln Gln Lys Leu Gln Leu Gln Glu Ala Cys 130 135 140 Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Val Glu 145 150 155 160 Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 165 170 175 Gly Lys Met Arg Val Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Arg 180 185 190 Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 195 200 205 Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 210 215 220 Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 225 230 235 240 Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ser Pro 245 250 255 Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp Asp Phe 260 265 270 Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Ala Leu 275 280 285 Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 290 295 300 Ser Ser Ser Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 305 310 315 320 Ala Gly Glu Asp Pro Arg Gln Phe Asp Lys Ala Val Ala Val Val Ala 325 330 335 His Gln Gln Leu Ser Glu Gly Glu His Tyr Trp Glu Val Glu Val Gly 340 345 350 Asp Lys Pro Arg Trp Ala Leu Gly Val Ile Ala Ala Glu Gly Pro Arg 355 360 365 Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 370 375 380 Leu Arg Glu Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 385 390 395 400 Arg Ala Leu Arg Ser Pro Glu Arg Arg Pro Thr Arg Ile Gly Leu Tyr 405 410 415 Leu Ser Phe Gly Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Ala 420 425 430 Asp Ala Leu Val Pro Leu Phe Ala Phe His Glu Arg Leu Pro Gly Pro 435 440 445 Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ser 450 455 460 Gln Pro Leu Leu Leu Val Gly Ser Glu Gly Ala Glu Ala 465 470 475 < 210 > 12 < 211 > 482 < 212 > PRT < 213 > Bos sp . < 220 > < 221 > PEPTIDE < 222 > ( 1 ) . .( 482 ) < 223 > Bovine MG 53 < 400 > 12 Met Ser Ala Ala Pro Gly Leu Leu His Gln Glu Leu Ser Cys Pro Leu 1 5 10 15 Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 20 25 30 Phe Cys Arg Ala Cys Leu Ser Arg Val Ala Gly Glu Pro Ala Ala Asp 35 40 45 Gly Thr Val Leu Cys Pro Ser Cys Gln Ala Pro Thr Arg Pro Gln Ala 50 55 60 Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 65 70 75 80 Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 85 90 95 Cys Glu Gln Asp Arg Ala Leu Val Cys Gly Val Cys Ala Ser Leu Gly 100 105 110 Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 115 120 125 Leu Lys Thr Gln Leu Pro Gln Gln Lys Met Gln Leu Gln Glu Ala Cys 130 135 140 Met Arg Lys Glu Lys Ser Val Ala Leu Leu Glu His Gln Leu Leu Glu 145 150 155 160 Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 165 170 175 Gly Lys Met Arg Leu Phe Leu Ala Ala Leu Glu Gly Ser Leu Asp Arg 180 185 190 Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 195 200 205 Leu Gly Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 210 215 220 Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 225 230 235 240 Tyr Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ala Glu Ser Pro 245 250 255 Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp Asp Phe 260 265 270 Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro Ala Arg 275 280 285 Gln Glu Leu Thr Phe Asp Pro Ser Thr Ala His Pro Ser Leu Val Leu 290 295 300 Ser Asn Ser Gly Arg Cys Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 305 310 315 320 Ala Gly Glu Asp Pro Arg Gln Phe Asp Lys Ala Val Ala Val Val Thr 325 330 335 His Gln Leu Leu Ser Glu Gly Glu His Tyr Trp Glu Val Glu Val Gly 340 345 350 Asp Lys Pro Arg Trp Ala Leu Gly Val Ile Gly Ala Gln Ala Gly Arg 355 360 365 Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 370 375 380 Leu Arg Asp Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 385 390 395 400 Arg Ala Leu Arg Thr Pro Glu Arg Arg Pro Thr Arg Ile Gly Ile Tyr 405 410 415 Leu Ser Phe Gly Asp Gly Val Leu Ser Phe Tyr Asp Ala Ser Asp Pro 420 425 430 Asp Ala Leu Glu Leu Leu Phe Ala Phe His Glu Arg Leu Pro Gly Pro 435 440 445 Val Tyr Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 450 455 460 Gln Pro Leu Leu Leu Val Gly Pro Glu Val Ser Gly Gly Ser Gly Ser 465 470 475 480 Glu Ala < 210 > 13 < 211 > 477 < 212 > PRT < 213 > Rattus sp . < 220 > < 221 > PEPTIDE < 222 > ( 1 ) . .( 477 ) < 223 > Rat MG 53 < 400 > 13 Met Ser Thr Ala Pro Gly Leu Leu Arg Gln Glu Leu Ser Cys Pro Leu 1 5 10 15 Cys Leu Gln Leu Phe Asp Ala Pro Val Thr Ala Glu Cys Gly His Ser 20 25 30 Phe Cys Arg Ala Cys Leu Ile Arg Val Ala Gly Glu Pro Ala Asp Asp 35 40 45 Gly Thr Val Ala Cys Pro Cys Cys Gln Ala Ser Thr Arg Pro Gln Ala 50 55 60 Leu Ser Thr Asn Leu Gln Leu Ala Arg Leu Val Glu Gly Leu Ala Gln 65 70 75 80 Val Pro Gln Gly His Cys Glu Glu His Leu Asp Pro Leu Ser Ile Tyr 85 90 95 Cys Glu Gln Asp Arg Thr Leu Val Cys Gly Val Cys Ala Ser Leu Gly 100 105 110 Ser His Arg Gly His Arg Leu Leu Pro Ala Ala Glu Ala His Ala Arg 115 120 125 Leu Lys Thr Gln Leu Pro Gln Gln Lys Ala Gln Leu Gln Glu Ala Cys 130 135 140 Met Arg Lys Glu Lys Ser Val Ala Val Leu Glu His Gln Leu Val Glu 145 150 155 160 Val Glu Glu Thr Val Arg Gln Phe Arg Gly Ala Val Gly Glu Gln Leu 165 170 175 Gly Lys Met Arg Met Phe Leu Ala Ala Leu Glu Ser Ser Leu Asp Arg 180 185 190 Glu Ala Glu Arg Val Arg Gly Glu Ala Gly Val Ala Leu Arg Arg Glu 195 200 205 Leu Ser Ser Leu Asn Ser Tyr Leu Glu Gln Leu Arg Gln Met Glu Lys 210 215 220 Val Leu Glu Glu Val Ala Asp Lys Pro Gln Thr Glu Phe Leu Met Lys 225 230 235 240 Phe Cys Leu Val Thr Ser Arg Leu Gln Lys Ile Leu Ser Glu Ser Pro 245 250 255 Pro Pro Ala Arg Leu Asp Ile Gln Leu Pro Val Ile Ser Asp Asp Phe 260 265 270 Lys Phe Gln Val Trp Lys Lys Met Phe Arg Ala Leu Met Pro Glu Leu 275 280 285 Glu Glu Leu Thr Phe Asp Pro Ser Ser Ala His Pro Ser Leu Val Val 290 295 300 Ser Ala Ser Gly Arg Arg Val Glu Cys Ser Glu Gln Lys Ala Pro Pro 305 310 315 320 Ala Gly Glu Asp Thr Cys Gln Phe Asp Lys Thr Val Ala Val Val Ala 325 330 335 Lys Gln Leu Leu Ser Gln Gly Glu His Tyr Trp Glu Val Glu Val Gly 340 345 350 Asp Lys Pro Arg Trp Ala Leu Gly Val Met Ala Ala Asp Ala Ser Arg 355 360 365 Arg Gly Arg Leu His Ala Val Pro Ser Gln Gly Leu Trp Leu Leu Gly 370 375 380 Leu Arg Asp Gly Lys Ile Leu Glu Ala His Val Glu Ala Lys Glu Pro 385 390 395 400 Arg Ala Leu Arg Thr Pro Glu Arg Pro Pro Ala Arg Ile Gly Leu Tyr 405 410 415 Leu Ser Phe Ala Asp Gly Val Leu Thr Phe Tyr Asp Ala Ser Asn Thr 420 425 430 Asp Ala Leu Thr Pro Leu Phe Ser Phe His Glu Arg Leu Pro Gly Pro 435 440 445 Val Tyr Pro Met Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ser 450 455 460 Gln Pro Leu Leu Leu Val Gly Pro Asp Ser Glu Gln Ala 465 470 475 < 210 > 14 < 211 > 477 < 212 > PRT < 213 > Xenopus laevis < 220 > < 221 > PEPTIDE < 222 > ( 1 ) . .( 477 ) < 223 > Xenopus laevis < 400 > 14 Met Ser Thr Pro Gln Leu Met Gln Gly Met Gln Lys Asp Leu Thr Cys 1 5 10 15 Gln Leu Cys Leu Glu Leu Phe Arg Ala Pro Val Thr Pro Glu Cys Gly 20 25 30 His Thr Phe Cys Gln Gly Cys Leu Thr Gly Val Pro Lys Asn Gln Asp 35 40 45 Gln Asn Gly Ser Thr Pro Cys Pro Thr Cys Gln Ser Pro Ser Arg Pro 50 55 60 Glu Thr Leu Gln Ile Asn Arg Gln Leu Glu His Leu Val Gln Ser Phe 65 70 75 80 Lys Gln Val Pro Gln Gly His Cys Leu Glu His Met Asp Pro Leu Ser 85 90 95 Val Tyr Cys Glu Gln Asp Lys Glu Leu Ile Cys Gly Val Cys Ala Ser 100 105 110 Leu Gly Lys His Lys Gly His Asn Ile Ile Thr Ala Ser Glu Ala Phe 115 120 125 Ala Lys Leu Lys Arg Gln Leu Pro Gln Gln Gln Val Ile Leu Gln Glu 130 135 140 Ala Arg Leu Lys Lys Glu Lys Thr Val Ala Val Leu Asp Arg Gln Val 145 150 155 160 Ala Glu Val Gln Asp Thr Val Ser Arg Phe Lys Gly Asn Val Lys His 165 170 175 Gln Leu Asn Ala Met Arg Ser Tyr Leu Asn Ile Met Glu Ala Ser Leu 180 185 190 Gly Lys Glu Ala Asp Lys Ala Glu Ser Ala Ala Thr Glu Ala Leu Leu 195 200 205 Val Glu Arg Lys Thr Met Gly His Tyr Leu Asp Gln Leu Arg Gln Met 210 215 220 Glu Gly Val Leu Lys Asp Val Glu Gly Gln Glu Gln Thr Glu Phe Leu 225 230 235 240 Arg Lys Tyr Cys Val Val Ala Ala Arg Leu Asn Lys Ile Leu Ser Glu 245 250 255 Ser Pro Pro Pro Gly Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp 260 265 270 Glu Phe Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro 275 280 285 Ala Leu Glu Asn Met Thr Phe Asp Pro Asp Thr Ala Gln Gln Tyr Leu 290 295 300 Val Val Ser Ser Glu Gly Lys Ser Val Glu Cys Ala Asp Gln Lys Gln 305 310 315 320 Ser Val Ser Asp Glu Pro Asn Arg Phe Asp Lys Ser Asn Cys Leu Val 325 330 335 Ser Lys Gln Ser Phe Thr Glu Gly Glu His Tyr Trp Glu Val Ile Val 340 345 350 Glu Asp Lys Pro Arg Trp Ala Leu Gly Ile Ile Ser Glu Thr Ala Asn 355 360 365 Arg Lys Gly Lys Leu His Ala Thr Pro Ser Asn Gly Phe Trp Ile Ile 370 375 380 Gly Cys Lys Glu Gly Lys Val Tyr Glu Ala His Thr Glu Gln Lys Glu 385 390 395 400 Pro Arg Val Leu Arg Val Glu Gly Arg Pro Glu Lys Ile Gly Val Tyr 405 410 415 Leu Ser Phe Ser Asp Gly Val Val Ser Phe Phe Asp Ser Ser Asp Glu 420 425 430 Asp Asn Leu Lys Leu Leu Tyr Thr Phe Asn Glu Arg Phe Ser Gly Arg 435 440 445 Leu His Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ser 450 455 460 Gln Pro Leu Lys Ile Phe Tyr Pro Pro Ala Glu Gln Leu 465 470 475 < 210 > 15 < 211 > 477 < 212 > PRT < 213 > Xenopus sp . < 220 > < 221 > PEPTIDE < 222 > ( 1 ) . .( 477 ) < 223 > Xenopus tropicalis MG 53 < 400 > 15 Met Ser Thr Pro Gln Leu Met Gln Gly Met Gln Lys Asp Leu Thr Cys 1 5 10 15 Pro Leu Cys Leu Glu Leu Phe Arg Ala Pro Val Thr Pro Glu Cys Gly 20 25 30 His Thr Phe Cys Gln Gly Cys Leu Thr Gly Ala Pro Lys Asn Gln Asp 35 40 45 Gln Asn Gly Ser Thr Pro Cys Pro Thr Cys Gln Thr Pro Ser Arg Pro 50 55 60 Glu Thr Leu Gln Ile Asn Arg Gln Leu Glu His Leu Val Gln Ser Phe 65 70 75 80 Lys Gln Val Pro Lys Gly His Cys Leu Glu His Leu Asp Pro Leu Ser 85 90 95 Val Tyr Cys Glu Gln Asp Lys Glu Leu Ile Cys Gly Val Cys Ala Ser 100 105 110 Leu Gly Lys His Lys Gly His Asn Ile Ile Thr Ala Ala Glu Ala Tyr 115 120 125 Ala Lys Leu Lys Arg Gln Leu Pro Gln Gln Gln Val Ile Leu Gln Glu 130 135 140 Ala Arg Leu Lys Lys Glu Lys Thr Val Ala Val Leu Asp Arg Gln Val 145 150 155 160 Ala Glu Val Gln Asp Thr Val Ser Arg Phe Lys Gly Asn Val Lys His 165 170 175 Gln Leu Asn Ala Met Arg Ser Tyr Leu Ser Ile Met Glu Ala Ser Leu 180 185 190 Ser Lys Glu Ala Asp Asn Ala Glu His Thr Ala Thr Glu Ala Leu Leu 195 200 205 Val Glu Arg Lys Thr Met Gly His Tyr Leu Asp Gln Leu Arg Gln Met 210 215 220 Asp Gly Val Leu Lys Asp Val Glu Ser Gln Glu Gln Thr Glu Phe Leu 225 230 235 240 Arg Lys Tyr Cys Val Val Ala Ala Arg Leu Asn Lys Ile Leu Ala Glu 245 250 255 Ser Pro Pro Pro Gly Arg Leu Asp Ile Gln Leu Pro Ile Ile Ser Asp 260 265 270 Glu Phe Lys Phe Gln Val Trp Arg Lys Met Phe Arg Ala Leu Met Pro 275 280 285 Ala Leu Glu Asn Leu Thr Phe Asp Pro Asp Thr Ala Gln Gln Asn Leu 290 295 300 Val Val Phe Ser Asp Gly Lys Ser Val Glu Cys Ser Glu Gln Lys Gln 305 310 315 320 Ser Val Ser Asp Glu Pro Asn Arg Phe Asp Lys Ser Asn Cys Leu Val 325 330 335 Ser Lys Glu Ser Phe Thr Glu Gly Glu His Tyr Trp Glu Val Leu Val 340 345 350 Glu Asp Lys Pro Arg Trp Ala Leu Gly Val Ile Ser Glu Thr Ala Asn 355 360 365 Arg Lys Gly Lys Leu His Ala Ser Pro Ser Asn Gly Phe Trp Leu Ile 370 375 380 Gly Cys Lys Glu Gly Lys Val Tyr Glu Ala His Thr Glu Gln Lys Glu 385 390 395 400 Pro Arg Val Leu Arg Val Glu Gly Arg Pro Glu Lys Ile Gly Ile Tyr 405 410 415 Leu Ser Phe Ser Asp Gly Val Val Ser Phe Phe Asp Ser Ser Asp Glu 420 425 430 Asp Asn Ile Lys Leu Leu Tyr Thr Phe Asn Glu Arg Phe Ser Gly Arg 435 440 445 Leu His Pro Phe Phe Asp Val Cys Trp His Asp Lys Gly Lys Asn Ala 450 455 460 Gln Pro Leu Lys Ile Phe Tyr Pro Pro Ala Glu Gln Leu 465 470 475 < 210 > 16 < 211 > 101 < 212 > PRT < 213 > Human immunodeficiency virus type 1 < 220 > < 221 > PEPTIDE < 222 > ( 1 ) . .( 101 ) < 223 > HIV - 1 TAT protein < 400 > 16 Met Glu Pro Val Asp Pro Asn Leu Glu Pro Trp Lys His Pro Gly Ser 1 5 10 15 Gln Pro Pro Thr Ala Cys Ser Lys Cys Tyr Cys Lys Lys Cys Cys Trp 20 25 30 His Cys Gln Leu Cys Phe Leu Lys Lys Gly Leu Gly Ile Ser Tyr Gly 35 40 45 Arg Lys Lys Arg Lys His Arg Arg Gly Thr Pro Gln Ser Ser Lys Asp 50 55 60 His Gln Asn Pro Ile Pro Glu Gln Pro Leu Pro Ile Ile Arg Gly Asn 65 70 75 80 Gln Thr Gly Pro Lys Glu Gln Lys Lys Thr Val Ala Ser Lys Ala Glu 85 90 95 Arg Asp Leu Cys Ala 100