SEQUENCE LISTING < 110 > Vor Biopharma , Inc . < 120 > COMPOSITIONS AND METHODS FOR INHIBITION OF LINEAGE SPECIFIC PROTEINS < 130 > V 0291 . 70001 WO 00 < 140 > Not Yet Assigned < 141 > Concurrently Herewith < 150 > US 62 / 464 , 975 < 151 > 2017 - 02 - 28 < 160 > 51 < 170 > PatentIn version 3 . 5 < 210 > 1 < 211 > 363 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic polypeptide < 400 > 1 Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 1 5 10 15 Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 35 40 45 Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 50 55 60 Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 65 70 75 80 Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 85 90 95 Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 100 105 110 Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 115 120 125 Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 130 135 140 Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 145 150 155 160 Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 165 170 175 Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 180 185 190 His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 195 200 205 Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 210 215 220 Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 225 230 235 240 Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly 245 250 255 Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 260 265 270 Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 275 280 285 Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 290 295 300 Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr 305 310 315 320 Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu 325 330 335 Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys 340 345 350 Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr 355 360 < 210 > 2 < 211 > 364 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic polypeptide < 400 > 2 Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 1 5 10 15 Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 35 40 45 Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 50 55 60 Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 65 70 75 80 Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 85 90 95 Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 100 105 110 Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 115 120 125 Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 130 135 140 Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 145 150 155 160 Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 165 170 175 Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 180 185 190 His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 195 200 205 Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 210 215 220 Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 225 230 235 240 Gly Ile Phe Pro Gly Asp Gly Thr Ala Arg Asn Asp Thr Arg Ala Gly 245 250 255 Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 260 265 270 Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 275 280 285 Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 290 295 300 Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr 305 310 315 320 Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu 325 330 335 Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys 340 345 350 Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 355 360 < 210 > 3 < 211 > 364 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic polypeptide < 400 > 3 Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 1 5 10 15 Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Val Pro 35 40 45 Phe Phe Glu Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 50 55 60 Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 65 70 75 80 Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 85 90 95 Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 100 105 110 Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 115 120 125 Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 130 135 140 Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 145 150 155 160 Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 165 170 175 Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 180 185 190 His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 195 200 205 Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 210 215 220 Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 225 230 235 240 Gly Ile Phe Pro Gly Asp Gly Thr Ala Arg Asn Asp Thr Arg Ala Gly 245 250 255 Val Val His Gly Ala Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala 260 265 270 Leu Cys Leu Cys Leu Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys 275 280 285 Ala Ala Arg Thr Ala Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly 290 295 300 Ser Ala Ser Pro Lys His Gln Lys Lys Ser Lys Leu His Gly Pro Thr 305 310 315 320 Glu Thr Ser Ser Cys Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu 325 330 335 Glu Leu His Tyr Ala Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys 340 345 350 Asp Thr Ser Thr Glu Tyr Ser Glu Val Arg Thr Gln 355 360 < 210 > 4 < 211 > 359 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic polypeptide < 400 > 4 Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 1 5 10 15 Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 35 40 45 Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 50 55 60 Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 65 70 75 80 Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 85 90 95 Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 100 105 110 Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 115 120 125 Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 130 135 140 Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 145 150 155 160 Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 165 170 175 Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 180 185 190 His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 195 200 205 Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 210 215 220 Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 225 230 235 240 Gly Ile Phe Pro Gly Asp Gly Ser Arg Ala Gly Val Val His Gly Ala 245 250 255 Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala Leu Cys Leu Cys Leu 260 265 270 Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys Ala Ala Arg Thr Ala 275 280 285 Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly Ser Ala Ser Pro Lys 290 295 300 His Gln Lys Lys Ser Lys Leu His Gly Pro Thr Glu Thr Ser Ser Cys 305 310 315 320 Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu Glu Leu His Tyr Ala 325 330 335 Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys Asp Thr Ser Thr Glu 340 345 350 Tyr Ser Glu Val Arg Thr Gln 355 < 210 > 5 < 211 > 359 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic polypeptide < 400 > 5 Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 1 5 10 15 Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 35 40 45 Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 50 55 60 Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 65 70 75 80 Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 85 90 95 Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 100 105 110 Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 115 120 125 Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 130 135 140 Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 145 150 155 160 Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 165 170 175 Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 180 185 190 His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 195 200 205 Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 210 215 220 Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 225 230 235 240 Gly Ile Phe Pro Gly Asp Gly Ser Gly Ala Gly Val Val His Gly Ala 245 250 255 Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala Leu Cys Leu Cys Leu 260 265 270 Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys Ala Ala Arg Thr Ala 275 280 285 Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly Ser Ala Ser Pro Lys 290 295 300 His Gln Lys Lys Ser Lys Leu His Gly Pro Thr Glu Thr Ser Ser Cys 305 310 315 320 Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu Glu Leu His Tyr Ala 325 330 335 Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys Asp Thr Ser Thr Glu 340 345 350 Tyr Ser Glu Val Arg Thr Gln 355 < 210 > 6 < 211 > 359 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic polypeptide < 400 > 6 Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 1 5 10 15 Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Asn 35 40 45 Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala Ile Ile Ser Arg 50 55 60 Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu Val Gln Glu Glu 65 70 75 80 Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser Arg Asn Asn Cys 85 90 95 Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn Gly Ser Tyr Phe 100 105 110 Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr Lys Ser Pro Gln 115 120 125 Leu Ser Val His Val Thr Asp Leu Thr His Arg Pro Lys Ile Leu Ile 130 135 140 Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn Leu Thr Cys Ser Val 145 150 155 160 Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe Ser Trp Leu Ser 165 170 175 Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr His Ser Ser Val Leu 180 185 190 Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr Asn Leu Thr Cys Gln 195 200 205 Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu Arg Thr Ile Gln Leu 210 215 220 Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly Ile Phe Pro Gly 225 230 235 240 Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly Val Val His Gly Ala 245 250 255 Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala Leu Cys Leu Cys Leu 260 265 270 Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys Ala Ala Arg Thr Ala 275 280 285 Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly Ser Ala Ser Pro Lys 290 295 300 His Gln Lys Lys Ser Lys Leu His Gly Pro Thr Glu Thr Ser Ser Cys 305 310 315 320 Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu Glu Leu His Tyr Ala 325 330 335 Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys Asp Thr Ser Thr Glu 340 345 350 Tyr Ser Glu Val Arg Thr Gln 355 < 210 > 7 < 211 > 359 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic polypeptide < 400 > 7 Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 1 5 10 15 Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Pro 35 40 45 Tyr Tyr Asp Lys Asn Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly 50 55 60 Ala Ile Ile Ser Arg Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln 65 70 75 80 Glu Val Gln Glu Glu Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro 85 90 95 Ser Arg Asn Asn Cys Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp 100 105 110 Asn Gly Ser Tyr Phe Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser 115 120 125 Tyr Lys Ser Pro Gln Leu Ser Val His Val Thr Asp Leu Thr His Arg 130 135 140 Pro Lys Ile Leu Ile Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn 145 150 155 160 Leu Thr Cys Ser Val Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile 165 170 175 Phe Ser Trp Leu Ser Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr 180 185 190 His Ser Ser Val Leu Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr 195 200 205 Asn Leu Thr Cys Gln Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu 210 215 220 Arg Thr Ile Gln Leu Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr 225 230 235 240 Gly Ile Phe Pro Gly Asp Gly Ser Gly Lys Gly Val Val His Gly Ala 245 250 255 Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala Leu Cys Leu Cys Leu 260 265 270 Ile Phe Phe Ile Val Lys Thr His Arg Arg Lys Ala Ala Arg Thr Ala 275 280 285 Val Gly Arg Asn Asp Thr His Pro Thr Thr Gly Ser Ala Ser Pro Lys 290 295 300 His Gln Lys Lys Ser Lys Leu His Gly Pro Thr Glu Thr Ser Ser Cys 305 310 315 320 Ser Gly Ala Ala Pro Thr Val Glu Met Asp Glu Glu Leu His Tyr Ala 325 330 335 Ser Leu Asn Phe His Gly Met Asn Pro Ser Lys Asp Thr Ser Thr Glu 340 345 350 Tyr Ser Glu Val Arg Thr Gln 355 < 210 > 8 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic polypeptide < 400 > 8 Ser Gly Lys Gln Glu 1 5 < 210 > 9 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic polypeptide < 400 > 9 Ile Pro Tyr Tyr Asp 1 5 < 210 > 10 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic polypeptide < 400 > 10 Gly Lys Gln Glu Thr 1 5 < 210 > 11 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic polypeptide < 400 > 11 Lys Gln Glu Thr Arg 1 5 < 210 > 12 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic polypeptide < 400 > 12 Pro Tyr Tyr Asp Lys 1 5 < 210 > 13 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic polypeptide < 400 > 13 Gln Glu Thr Arg Ala 1 5 < 210 > 14 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 14 gaggctggaa acttgagttg 20 < 210 > 15 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 15 gagggtaagt tactcagcca 20 < 210 > 16 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 16 aaattcagga aagggttgga 20 < 210 > 17 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 17 aagggttgga aggactctgc 20 < 210 > 18 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 18 agcagaggac tccaaaagct 20 < 210 > 19 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 19 cacaccaggt tatagagcag 20 < 210 > 20 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 20 ctgctctata acctggtgtg 20 < 210 > 21 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 21 acctggtgtg aggagtcggg 20 < 210 > 22 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 22 cacagcgtta tctccctctg 20 < 210 > 23 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 23 cggacctctt ctgtccatgg 20 < 210 > 24 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 24 ccatggacag aagaggtccg 20 < 210 > 25 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 25 gggcgaaact cggagctagg 20 < 210 > 26 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 26 gctaggtggg cagactcctg 20 < 210 > 27 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 27 gctgtgggga gaggggttgt 20 < 210 > 28 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 28 ctgtggggag aggggttgtc 20 < 210 > 29 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 29 tggggaaacg agggtcagct 20 < 210 > 30 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 30 gggcccctgt ggggaaacga 20 < 210 > 31 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 31 agggcccctg tggggaaacg 20 < 210 > 32 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 32 gctgaccctc gtttccccac 20 < 210 > 33 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 33 ctgaccctcg tttccccaca 20 < 210 > 34 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 34 tgaccctcgt ttccccacag 20 < 210 > 35 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 35 ccatagccag ggcccctgtg 20 < 210 > 36 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 36 gcatgtgaca ggtgaggcac 20 < 210 > 37 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 37 tgaggcacag gcttcagaag 20 < 210 > 38 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 38 aggcttcaga agtggccgca 20 < 210 > 39 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 39 ggcttcagaa gtggccgcaa 20 < 210 > 40 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 40 gtacccatga acttcccttg 20 < 210 > 41 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 41 gtggccgcaa gggaagttca 20 < 210 > 42 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 42 tggccgcaag ggaagttcat 20 < 210 > 43 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 43 ggaagttcat gggtactgca 20 < 210 > 44 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 44 ttcatgggta ctgcagggca 20 < 210 > 45 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 45 ctaaacccct cccagtacca 20 < 210 > 46 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 46 cactcacctg cccacagcag 20 < 210 > 47 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 47 ccctgctgtg ggcaggtgag 20 < 210 > 48 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 48 tgggcaggtg agtggctgtg 20 < 210 > 49 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 49 ggtgagtggc tgtggggaga 20 < 210 > 50 < 211 > 20 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic polynucleotide < 400 > 50 gtgagtggct gtggggagag 20 < 210 > 51 < 211 > 281 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic polypeptide < 400 > 51 Met Pro Leu Leu Leu Leu Leu Pro Leu Leu Trp Ala Gly Ala Leu Ala 1 5 10 15 Met Asp Pro Asn Phe Trp Leu Gln Val Gln Glu Ser Val Thr Val Gln 20 25 30 Glu Gly Leu Cys Val Leu Val Pro Cys Thr Phe Phe His Pro Ile Asn 35 40 45 Ser Pro Val His Gly Tyr Trp Phe Arg Glu Gly Ala Ile Ile Ser Arg 50 55 60 Asp Ser Pro Val Ala Thr Asn Lys Leu Asp Gln Glu Val Gln Glu Glu 65 70 75 80 Thr Gln Gly Arg Phe Arg Leu Leu Gly Asp Pro Ser Arg Asn Asn Cys 85 90 95 Ser Leu Ser Ile Val Asp Ala Arg Arg Arg Asp Asn Gly Ser Tyr Phe 100 105 110 Phe Arg Met Glu Arg Gly Ser Thr Lys Tyr Ser Tyr Lys Ser Pro Gln 115 120 125 Leu Ser Val His Val Thr Asp Leu Thr His Arg Pro Lys Ile Leu Ile 130 135 140 Pro Gly Thr Leu Glu Pro Gly His Ser Lys Asn Leu Thr Cys Ser Val 145 150 155 160 Ser Trp Ala Cys Glu Gln Gly Thr Pro Pro Ile Phe Ser Trp Leu Ser 165 170 175 Ala Ala Pro Thr Ser Leu Gly Pro Arg Thr Thr His Ser Ser Val Leu 180 185 190 Ile Ile Thr Pro Arg Pro Gln Asp His Gly Thr Asn Leu Thr Cys Gln 195 200 205 Val Lys Phe Ala Gly Ala Gly Val Thr Thr Glu Arg Thr Ile Gln Leu 210 215 220 Asn Val Thr Tyr Val Pro Gln Asn Pro Thr Thr Gly Ile Phe Pro Gly 225 230 235 240 Asp Gly Ser Gly Lys Gln Glu Thr Arg Ala Gly Val Val His Gly Ala 245 250 255 Ile Gly Gly Ala Gly Val Thr Ala Leu Leu Ala Leu Cys Leu Cys Leu 260 265 270 Ile Phe Phe Ile Val Lys Thr His Arg 275 280