SEQUENCE LISTING < 110 > BRISTOL - MYERS SQUIBB COMPANY < 120 > ANTIBODIES TO ALPHA - SYNUCLEIN AND USES THEREOF < 130 > MXI - 554 PC < 140 > PCT / US 2018 / 000032 < 141 > 2018 - 02 - 16 < 150 > US 62 / 460 , 416 < 151 > 2017 - 02 - 17 < 160 > 182 < 170 > PatentIn version 3 . 5 < 210 > 1 < 211 > 140 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > misc _ feature < 223 > Human alpha - synuclein < 400 > 1 Met Asp Val Phe Met Lys Gly Leu Ser Lys Ala Lys Glu Gly Val Val 1 5 10 15 Ala Ala Ala Glu Lys Thr Lys Gln Gly Val Ala Glu Ala Ala Gly Lys 20 25 30 Thr Lys Glu Gly Val Leu Tyr Val Gly Ser Lys Thr Lys Glu Gly Val 35 40 45 Val His Gly Val Ala Thr Val Ala Glu Lys Thr Lys Glu Gln Val Thr 50 55 60 Asn Val Gly Gly Ala Val Val Thr Gly Val Thr Ala Val Ala Gln Lys 65 70 75 80 Thr Val Glu Gly Ala Gly Ser Ile Ala Ala Ala Thr Gly Phe Val Lys 85 90 95 Lys Asp Gln Leu Gly Lys Asn Glu Glu Gly Ala Pro Gln Glu Gly Ile 100 105 110 Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 115 120 125 Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 130 135 140 < 210 > 2 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 VH CDR 1 < 400 > 2 Ser Gly Arg Tyr Tyr Trp Ser 1 5 < 210 > 3 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 VH CDR 2 < 400 > 3 Tyr Ile Tyr Tyr Ser Gly Arg Thr Lys Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 < 210 > 4 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 VH CDR 3 < 400 > 4 Glu Arg Gly Tyr Leu Asp Tyr 1 5 < 210 > 5 < 211 > 12 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 VL CDR 1 < 400 > 5 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 < 210 > 6 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 VL CDR 2 < 400 > 6 Gly Ala Ser Ser Arg Ala Thr 1 5 < 210 > 7 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 VL CDR 3 < 400 > 7 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 < 210 > 8 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 VH < 400 > 8 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 20 25 30 Arg Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Arg Thr Lys Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Thr Arg Glu Arg Gly Tyr Leu Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 9 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 VL < 400 > 9 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 10 < 211 > 446 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 HC < 400 > 10 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 20 25 30 Arg Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Arg Thr Lys Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Thr Arg Glu Arg Gly Tyr Leu Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 115 120 125 Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 130 135 140 Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 145 150 155 160 Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 165 170 175 Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 180 185 190 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 195 200 205 Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 445 < 210 > 11 < 211 > 215 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 LC < 400 > 11 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 100 105 110 Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 115 120 125 Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 130 135 140 Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 145 150 155 160 Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 165 170 175 Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 180 185 190 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 195 200 205 Ser Phe Asn Arg Gly Glu Cys 210 215 < 210 > 12 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 - T 93 A VH CDR 1 < 400 > 12 Ser Gly Arg Tyr Tyr Trp Ser 1 5 < 210 > 13 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 - T 93 A VH CDR 2 < 400 > 13 Tyr Ile Tyr Tyr Ser Gly Arg Thr Lys Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 < 210 > 14 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 - T 93 A VH CDR 3 < 400 > 14 Glu Arg Gly Tyr Leu Asp Tyr 1 5 < 210 > 15 < 211 > 12 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 - T 93 A VL CDR 1 < 400 > 15 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 < 210 > 16 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 - T 93 A VL CDR 2 < 400 > 16 Gly Ala Ser Ser Arg Ala Thr 1 5 < 210 > 17 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 - T 93 A VL CDR 3 < 400 > 17 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 < 210 > 18 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 - T 93 A VH < 400 > 18 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 20 25 30 Arg Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Arg Thr Lys Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Glu Arg Gly Tyr Leu Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 19 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 - T 93 A VL < 400 > 19 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 20 < 211 > 446 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 - T 93 A HC < 400 > 20 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 20 25 30 Arg Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Arg Thr Lys Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Glu Arg Gly Tyr Leu Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 115 120 125 Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 130 135 140 Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 145 150 155 160 Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 165 170 175 Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 180 185 190 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 195 200 205 Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 445 < 210 > 21 < 211 > 215 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 - T 93 A LC < 400 > 21 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 100 105 110 Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 115 120 125 Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 130 135 140 Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 145 150 155 160 Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 165 170 175 Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 180 185 190 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 195 200 205 Ser Phe Asn Arg Gly Glu Cys 210 215 < 210 > 22 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 11 H 11 VH CDR 1 < 400 > 22 Ser Tyr Ala Met His 1 5 < 210 > 23 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 11 H 11 VH CDR 2 < 400 > 23 Ala Ile Gly Thr Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 < 210 > 24 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 11 H 11 VH CDR 3 < 400 > 24 Gly Asn Trp Glu Phe Asp Tyr 1 5 < 210 > 25 < 211 > 12 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 11 H 11 VL 1 CDR 1 < 400 > 25 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 < 210 > 26 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 11 H 11 VL 1 CDR 2 < 400 > 26 Gly Ala Ser Ser Arg Ala Thr 1 5 < 210 > 27 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 11 H 11 VL 1 CDR 3 < 400 > 27 Gln Gln Tyr Gly Ser Ser Pro Phe Thr 1 5 < 210 > 28 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 11 H 11 VL 2 CDR 1 < 400 > 28 Arg Ala Ser Gln Gly Ile Ser Ser Ala Leu Ala 1 5 10 < 210 > 29 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 11 H 11 VL 2 CDR 2 < 400 > 29 Asp Ala Ser Ser Leu Glu Ser 1 5 < 210 > 30 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 11 H 11 VL 2 CDR 3 < 400 > 30 Gln Gln Phe Asn Ser Tyr Pro 1 5 < 210 > 31 < 211 > 115 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 11 H 11 VH < 400 > 31 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val His Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Gly Thr Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Asn Trp Glu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser 115 < 210 > 32 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 11 H 11 VL 1 < 400 > 32 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys 100 105 < 210 > 33 < 211 > 105 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 11 H 11 VL 2 < 400 > 33 Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Pro Ile 35 40 45 Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Phe 85 90 95 Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 34 < 211 > 444 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 11 H 11 HC < 400 > 34 Glu Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val His Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Gly Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ala Ile Gly Thr Gly Gly Gly Thr Tyr Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Met Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Asn Trp Glu Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro 115 120 125 Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val 130 135 140 Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala 145 150 155 160 Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly 165 170 175 Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly 180 185 190 Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys 195 200 205 Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys 210 215 220 Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu 225 230 235 240 Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 245 250 255 Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 260 265 270 Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 275 280 285 Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 290 295 300 Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 305 310 315 320 Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 325 330 335 Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 340 345 350 Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 355 360 365 Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 370 375 380 Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 385 390 395 400 Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 405 410 415 Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 420 425 430 His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 < 210 > 35 < 211 > 215 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 11 H 11 LC 1 < 400 > 35 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Phe Thr Phe Gly Pro Gly Thr Lys Val Asp Ile Lys Arg Thr Val Ala 100 105 110 Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 115 120 125 Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 130 135 140 Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 145 150 155 160 Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 165 170 175 Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 180 185 190 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 195 200 205 Ser Phe Asn Arg Gly Glu Cys 210 215 < 210 > 36 < 211 > 212 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 11 H 11 LC 2 < 400 > 36 Ala Ile Gln Leu Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 1 5 10 15 Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Ile Ser Ser Ala 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Val Pro Ile 35 40 45 Tyr Asp Ala Ser Ser Leu Glu Ser Gly Val Pro Ser Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 65 70 75 80 Glu Asp Leu Ala Thr Tyr Tyr Cys Gln Gln Phe Asn Ser Tyr Pro Phe 85 90 95 Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser 100 105 110 Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala 115 120 125 Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 130 135 140 Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser 145 150 155 160 Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr 165 170 175 Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys 180 185 190 Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn 195 200 205 Arg Gly Glu Cys 210 < 210 > 37 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 15 A 5 VH CDR 1 < 400 > 37 Ser Gly Ser Tyr Tyr Trp Cys 1 5 < 210 > 38 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 15 A 5 VH CDR 2 < 400 > 38 Tyr Ile Tyr Tyr Ser Gly Arg Thr Lys Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 < 210 > 39 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 15 A 5 VH CDR 3 < 400 > 39 Glu Arg Gly Arg Phe Asp Tyr 1 5 < 210 > 40 < 211 > 12 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 15 A 5 VL CDR 1 < 400 > 40 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 < 210 > 41 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 15 A 5 VL CDR 2 < 400 > 41 Gly Ala Ser Ser Arg Ala Thr 1 5 < 210 > 42 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 15 A 5 VL CDR 3 < 400 > 42 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 < 210 > 43 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 15 A 5 VH < 400 > 43 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 20 25 30 Ser Tyr Tyr Trp Cys Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Arg Thr Lys Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Glu Arg Gly Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 44 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 15 A 5 VL < 400 > 44 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 45 < 211 > 446 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 15 A 5 HC < 400 > 45 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 20 25 30 Ser Tyr Tyr Trp Cys Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Arg Thr Lys Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Glu Arg Gly Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 115 120 125 Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 130 135 140 Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 145 150 155 160 Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 165 170 175 Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 180 185 190 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 195 200 205 Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 445 < 210 > 46 < 211 > 215 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 15 A 5 LC < 400 > 46 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 100 105 110 Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 115 120 125 Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 130 135 140 Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 145 150 155 160 Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 165 170 175 Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 180 185 190 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 195 200 205 Ser Phe Asn Arg Gly Glu Cys 210 215 < 210 > 47 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 21 A 3 VH CDR 1 < 400 > 47 Asn Arg Asn Tyr Tyr Trp Ser 1 5 < 210 > 48 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 21 A 3 VH CDR 2 < 400 > 48 Tyr Ile Tyr Tyr Ser Gly Arg Thr Lys Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 < 210 > 49 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 21 A 3 VH CDR 3 < 400 > 49 Glu Arg Gly Arg Phe Asp Tyr 1 5 < 210 > 50 < 211 > 12 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 21 A 3 VL CDR 1 < 400 > 50 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 < 210 > 51 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 21 A 3 VL CDR 2 < 400 > 51 Gly Ala Ser Ser Arg Ala Thr 1 5 < 210 > 52 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 21 A 3 VL CDR 3 < 400 > 52 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 < 210 > 53 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 21 A 3 VH < 400 > 53 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Asn Arg 20 25 30 Asn Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Arg Thr Lys Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Val Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Glu Arg Gly Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 54 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 21 A 3 VL < 400 > 54 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 55 < 211 > 446 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 21 A 3 HC < 400 > 55 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Asn Arg 20 25 30 Asn Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Arg Thr Lys Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Val Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Glu Arg Gly Arg Phe Asp Tyr Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 115 120 125 Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 130 135 140 Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 145 150 155 160 Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 165 170 175 Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 180 185 190 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 195 200 205 Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 445 < 210 > 56 < 211 > 215 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 21 A 3 LC < 400 > 56 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 100 105 110 Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 115 120 125 Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 130 135 140 Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 145 150 155 160 Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 165 170 175 Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 180 185 190 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 195 200 205 Ser Phe Asn Arg Gly Glu Cys 210 215 < 210 > 57 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 36 A 3 VH CDR 1 < 400 > 57 Ser Gly Ser Tyr Tyr Trp Ser 1 5 < 210 > 58 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 36 A 3 VH CDR 2 < 400 > 58 Tyr Ile Tyr Tyr Ser Gly Arg Thr Lys Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 < 210 > 59 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 36 A 3 VH CDR 3 < 400 > 59 Glu Arg Gly Trp Leu Asp Pro 1 5 < 210 > 60 < 211 > 12 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 36 A 3 VL CDR 1 < 400 > 60 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 < 210 > 61 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 36 A 3 VL CDR 2 < 400 > 61 Gly Ala Ser Ser Arg Ala Thr 1 5 < 210 > 62 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 36 A 3 VL CDR 3 < 400 > 62 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 < 210 > 63 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 36 A 3 VH < 400 > 63 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 20 25 30 Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Arg Thr Lys Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Arg Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Glu Arg Gly Trp Leu Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 64 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 36 A 3 VL < 400 > 64 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 < 210 > 65 < 211 > 446 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 36 A 3 HC < 400 > 65 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 20 25 30 Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Arg Thr Lys Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Arg Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Ala Arg Glu Arg Gly Trp Leu Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 115 120 125 Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 130 135 140 Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 145 150 155 160 Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 165 170 175 Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 180 185 190 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 195 200 205 Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 445 < 210 > 66 < 211 > 215 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 36 A 3 LC < 400 > 66 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala 100 105 110 Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 115 120 125 Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 130 135 140 Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 145 150 155 160 Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 165 170 175 Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 180 185 190 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 195 200 205 Ser Phe Asn Arg Gly Glu Cys 210 215 < 210 > 67 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 44 B 11 VH CDR 1 < 400 > 67 Ser Lys Tyr Met Ser 1 5 < 210 > 68 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 44 B 11 VH CDR 2 < 400 > 68 Val Met Tyr Ser Gly Gly Arg Arg Tyr Tyr Ala Asp Ser Val Lys Gly 1 5 10 15 < 210 > 69 < 211 > 6 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 44 B 11 VH CDR 3 < 400 > 69 Gly Asp Arg Gly Asp Tyr 1 5 < 210 > 70 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 44 B 11 VL CDR 1 < 400 > 70 Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 1 5 10 < 210 > 71 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 44 B 11 VL CDR 2 < 400 > 71 Asp Ala Ser Asn Arg Ala Thr 1 5 < 210 > 72 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 44 B 11 VL CDR 3 < 400 > 72 Gln Gln Arg Ser Asn Trp Pro Ile Thr 1 5 < 210 > 73 < 211 > 114 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 44 B 11 VH < 400 > 73 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Lys 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Met Tyr Ser Gly Gly Arg Arg Tyr Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Asp Arg Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 100 105 110 Ser Ser < 210 > 74 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 44 B 11 VL < 400 > 74 Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 < 210 > 75 < 211 > 443 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 44 B 11 HC < 400 > 75 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Ile Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Ser Ser Lys 20 25 30 Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Val Met Tyr Ser Gly Gly Arg Arg Tyr Tyr Ala Asp Ser Val Lys 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Arg Gly Asp Arg Gly Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val 100 105 110 Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser 115 120 125 Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys 130 135 140 Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 145 150 155 160 Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 165 170 175 Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 180 185 190 Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val 195 200 205 Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro 210 215 220 Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe 225 230 235 240 Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 245 250 255 Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 260 265 270 Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 275 280 285 Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 290 295 300 Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 305 310 315 320 Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 325 330 335 Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 340 345 350 Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 355 360 365 Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 370 375 380 Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 385 390 395 400 Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 405 410 415 Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 420 425 430 Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 < 210 > 76 < 211 > 214 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 44 B 11 LC < 400 > 76 Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp Pro Ile 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210 < 210 > 77 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 2 E 2 VH CDR 1 < 400 > 77 Ser Tyr Ala Met His 1 5 < 210 > 78 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 2 E 2 VH CDR 2 < 400 > 78 Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly < 210 > 79 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 2 E 2 VH CDR 3 < 400 > 79 Arg Gly Ser Gly Ser Tyr Tyr Asn Phe Asp Tyr 1 5 10 < 210 > 80 < 211 > 12 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 2 E 2 VL CDR 1 < 400 > 80 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 < 210 > 81 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 2 E 2 VL CDR 2 < 400 > 81 Gly Ala Ser Ser Arg Ala Thr 1 5 < 210 > 82 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 2 E 2 VL CDR 3 < 400 > 82 Gln Gln Tyr Gly Ser Ser Pro Thr 1 5 < 210 > 83 < 211 > 120 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 2 E 2 VH < 400 > 83 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Arg Gly Ser Gly Ser Tyr Tyr Asn Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser 115 120 < 210 > 84 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 2 E 2 VL < 400 > 84 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys 100 105 < 210 > 85 < 211 > 449 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 2 E 2 HC < 400 > 85 Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ala Val Ile Ser Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Arg Arg Gly Ser Gly Ser Tyr Tyr Asn Phe Asp Tyr Trp Gly Gln 100 105 110 Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 115 120 125 Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala 130 135 140 Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 145 150 155 160 Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 165 170 175 Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 180 185 190 Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys 195 200 205 Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp 210 215 220 Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala 225 230 235 240 Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 245 250 255 Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 260 265 270 Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 275 280 285 Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 290 295 300 Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 305 310 315 320 Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 325 330 335 Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 340 345 350 Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 355 360 365 Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 370 375 380 Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 385 390 395 400 Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 405 410 415 Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 420 425 430 Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 435 440 445 Gly < 210 > 86 < 211 > 214 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 2 E 2 LC < 400 > 86 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Thr Phe Gly Gln Gly Thr Arg Leu Glu Ile Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210 < 210 > 87 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 23 H 8 VH CDR 1 < 400 > 87 Ser Tyr Gly Met Asn 1 5 < 210 > 88 < 211 > 17 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 23 H 8 VH CDR 2 < 400 > 88 Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly < 210 > 89 < 211 > 4 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 23 H 8 VH CDR 3 < 400 > 89 Trp Gly Ser Tyr 1 < 210 > 90 < 211 > 12 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 23 H 8 VL 1 CDR 1 < 400 > 90 Arg Ala Ser Gln Ser Val Ser Arg Ser Tyr Leu Ala 1 5 10 < 210 > 91 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 23 H 8 VL 1 CDR 2 < 400 > 91 Gly Ala Ser Ser Arg Ala Thr 1 5 < 210 > 92 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 23 H 8 VL 1 CDR 3 < 400 > 92 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 < 210 > 93 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 23 H 8 VL 2 CDR 1 < 400 > 93 Arg Ala Ser Gln Gly Val Ser Ser Tyr Leu Ala 1 5 10 < 210 > 94 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 23 H 8 VL 2 CDR 2 < 400 > 94 Asp Ala Ser Asn Arg Ala Thr 1 5 < 210 > 95 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 23 H 8 VL 2 CDR 3 < 400 > 95 Gln Gln Arg Ser Asn Trp His Thr 1 5 < 210 > 96 < 211 > 12 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 23 H 8 VL 3 CDR 1 < 400 > 96 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 < 210 > 97 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 23 H 8 VL 3 CDR 2 < 400 > 97 Gly Ala Ser Ser Arg Ala Thr 1 5 < 210 > 98 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 23 H 8 VL 3 CDR 3 < 400 > 98 Gln Gln Tyr Gly Ser Ser Pro Thr 1 5 < 210 > 99 < 211 > 113 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 23 H 8 VH < 400 > 99 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Asn Trp Gly Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser < 210 > 100 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 23 H 8 VL 1 < 400 > 100 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Leu Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 101 < 211 > 106 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 23 H 8 VL 2 < 400 > 101 Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Pro Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp His Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 102 < 211 > 107 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 23 H 8 VL 3 < 400 > 102 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 103 < 211 > 442 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 23 H 8 HC < 400 > 103 Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 20 25 30 Gly Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Tyr Ile Ser Ser Ser Ser Ser Thr Ile Tyr Tyr Ala Asp Ser Val 50 55 60 Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser Leu Tyr 65 70 75 80 Leu Gln Met Asn Ser Leu Arg Asp Glu Asp Thr Ala Val Tyr Tyr Cys 85 90 95 Ala Asn Trp Gly Ser Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser 100 105 110 Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser 115 120 125 Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp 130 135 140 Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr 145 150 155 160 Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr 165 170 175 Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln 180 185 190 Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp 195 200 205 Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro 210 215 220 Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro 225 230 235 240 Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 245 250 255 Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn 260 265 270 Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 275 280 285 Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 290 295 300 Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 305 310 315 320 Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys 325 330 335 Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 340 345 350 Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 355 360 365 Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 370 375 380 Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 385 390 395 400 Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 405 410 415 Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 420 425 430 Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 < 210 > 104 < 211 > 215 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 23 H 8 LC 1 < 400 > 104 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Arg Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Leu Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 100 105 110 Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 115 120 125 Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 130 135 140 Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 145 150 155 160 Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 165 170 175 Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 180 185 190 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 195 200 205 Ser Phe Asn Arg Gly Glu Cys 210 215 < 210 > 105 < 211 > 213 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 23 H 8 LC 2 < 400 > 105 Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Gly Val Ser Ser Tyr 20 25 30 Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 35 40 45 Tyr Asp Ala Ser Asn Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser Gly 50 55 60 Ser Gly Pro Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 65 70 75 80 Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Arg Ser Asn Trp His Thr 85 90 95 Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro 100 105 110 Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr 115 120 125 Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 130 135 140 Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu 145 150 155 160 Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser 165 170 175 Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr Ala 180 185 190 Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser Phe 195 200 205 Asn Arg Gly Glu Cys 210 < 210 > 106 < 211 > 214 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 23 H 8 LC 3 < 400 > 106 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala 100 105 110 Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 115 120 125 Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 130 135 140 Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 145 150 155 160 Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 165 170 175 Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 180 185 190 Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 195 200 205 Phe Asn Arg Gly Glu Cys 210 < 210 > 107 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 1 E 8 VH CDR 1 < 400 > 107 Ser Gly Ser Tyr Tyr Trp Ser 1 5 < 210 > 108 < 211 > 16 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 1 E 8 VH CDR 2 < 400 > 108 Tyr Ile Tyr Tyr Ser Gly Arg Thr Lys Tyr Asn Pro Ser Leu Lys Ser 1 5 10 15 < 210 > 109 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 1 E 8 VH CDR 3 < 400 > 109 Glu Arg Gly Trp Phe Asp Pro 1 5 < 210 > 110 < 211 > 12 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 1 E 8 VL CDR 1 < 400 > 110 Arg Ala Ser Gln Ser Val Ser Ser Ser Tyr Leu Ala 1 5 10 < 210 > 111 < 211 > 7 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 1 E 8 VL CDR 2 < 400 > 111 Gly Ala Ser Ser Arg Ala Thr 1 5 < 210 > 112 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 1 E 8 VL CDR 3 < 400 > 112 Gln Gln Tyr Gly Ser Ser Pro Leu Thr 1 5 < 210 > 113 < 211 > 117 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 1 E 8 VH < 400 > 113 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 20 25 30 Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Arg Thr Lys Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Val Arg Glu Arg Gly Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser 115 < 210 > 114 < 211 > 108 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 1 E 8 VL < 400 > 114 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 100 105 < 210 > 115 < 211 > 446 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 1 E 8 HC < 400 > 115 Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 1 5 10 15 Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Gly Ser Val Ser Ser Gly 20 25 30 Ser Tyr Tyr Trp Ser Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 35 40 45 Trp Ile Gly Tyr Ile Tyr Tyr Ser Gly Arg Thr Lys Tyr Asn Pro Ser 50 55 60 Leu Lys Ser Arg Val Thr Ile Ser Val Asp Thr Ser Lys Asn Gln Phe 65 70 75 80 Ser Leu Lys Leu Arg Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 85 90 95 Cys Val Arg Glu Arg Gly Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu 100 105 110 Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 115 120 125 Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys 130 135 140 Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 145 150 155 160 Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 165 170 175 Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 180 185 190 Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn 195 200 205 Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His 210 215 220 Thr Cys Pro Pro Cys Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val 225 230 235 240 Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 245 250 255 Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 260 265 270 Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 275 280 285 Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 290 295 300 Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 305 310 315 320 Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 325 330 335 Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 340 345 350 Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 355 360 365 Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 370 375 380 Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 385 390 395 400 Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 405 410 415 Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 420 425 430 His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 435 440 445 < 210 > 116 < 211 > 215 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 1 E 8 LC < 400 > 116 Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Gly Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 85 90 95 Leu Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala 100 105 110 Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser 115 120 125 Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu 130 135 140 Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser 145 150 155 160 Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu 165 170 175 Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val 180 185 190 Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys 195 200 205 Ser Phe Asn Arg Gly Glu Cys 210 215 < 210 > 117 < 211 > 329 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > misc _ feature < 223 > Human IgG 1 f constant domain < 400 > 117 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly 325 < 210 > 118 < 211 > 329 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > misc _ feature < 223 > Human IgG 1 za ( allotypic variant ) < 400 > 118 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 225 230 235 240 Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly 325 < 210 > 119 < 211 > 329 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > misc _ feature < 223 > Human IgG 1 . 3 f < 400 > 119 Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys 1 5 10 15 Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr 20 25 30 Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser 35 40 45 Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser 50 55 60 Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr 65 70 75 80 Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys 85 90 95 Arg Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys 100 105 110 Pro Ala Pro Glu Ala Glu Gly Ala Pro Ser Val Phe Leu Phe Pro Pro 115 120 125 Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 130 135 140 Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 145 150 155 160 Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 165 170 175 Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 180 185 190 His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 195 200 205 Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 210 215 220 Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu Glu 225 230 235 240 Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 245 250 255 Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 260 265 270 Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 275 280 285 Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 290 295 300 Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 305 310 315 320 Gln Lys Ser Leu Ser Leu Ser Pro Gly 325 < 210 > 120 < 211 > 107 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > misc _ feature < 223 > Human IgG 1 kappa light chain constant region < 400 > 120 Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 1 5 10 15 Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 20 25 30 Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 35 40 45 Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 50 55 60 Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 65 70 75 80 Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 85 90 95 Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 100 105 < 210 > 121 < 211 > 6 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn epitope ( 123 - 128 ) < 400 > 121 Glu Ala Tyr Glu Met Pro 1 5 < 210 > 122 < 211 > 4 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn epitope ( 125 - 128 ) < 400 > 122 Tyr Glu Met Pro 1 < 210 > 123 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn epitope ( 130 - 138 ) < 400 > 123 Glu Glu Gly Tyr Gln Asp Tyr Glu Pro 1 5 < 210 > 124 < 211 > 10 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn epitope ( 130 - 139 ) < 400 > 124 Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu 1 5 10 < 210 > 125 < 211 > 8 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn epitope ( 119 - 126 ) < 400 > 125 Asp Pro Asp Asn Glu Ala Tyr Glu 1 5 < 210 > 126 < 211 > 9 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn epitope ( 130 - 138 ) < 400 > 126 Glu Glu Gly Tyr Gln Asp Tyr Glu Pro 1 5 < 210 > 127 < 211 > 4 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : C - terminal sequence < 400 > 127 Leu Ser Pro Gly 1 < 210 > 128 < 211 > 5 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : Peptide linker < 400 > 128 Pro Val Gly Val Val 1 5 < 210 > 129 < 211 > 57 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : pS 219 peptide < 220 > < 221 > MOD _ RES < 222 > ( 40 ) . .( 40 ) < 223 > PHOSPHORYLATION < 400 > 129 Ala Ala Thr Gly Phe Val Lys Lys Asp Gln Leu Gly Lys Asn Glu Glu 1 5 10 15 Gly Ala Pro Gln Glu Gly Ile Leu Glu Asp Met Pro Val Asp Pro Asp 20 25 30 Asn Glu Ala Tyr Glu Met Pro Ser Glu Glu Gly Tyr Gln Asp Tyr Glu 35 40 45 Pro Glu Ala His His His His His His 50 55 < 210 > 130 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 105 - 115 < 400 > 130 Glu Gly Ala Pro Gln Glu Gly Ile Leu Glu Asp 1 5 10 < 210 > 131 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 106 - 116 < 400 > 131 Gly Ala Pro Gln Glu Gly Ile Leu Glu Asp Met 1 5 10 < 210 > 132 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 107 - 117 < 400 > 132 Ala Pro Gln Glu Gly Ile Leu Glu Asp Met Pro 1 5 10 < 210 > 133 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 108 - 118 < 400 > 133 Pro Gln Glu Gly Ile Leu Glu Asp Met Pro Val 1 5 10 < 210 > 134 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 109 - 119 < 400 > 134 Gln Glu Gly Ile Leu Glu Asp Met Pro Val Asp 1 5 10 < 210 > 135 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 110 - 120 < 400 > 135 Glu Gly Ile Leu Glu Asp Met Pro Val Asp Pro 1 5 10 < 210 > 136 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 111 - 121 < 400 > 136 Gly Ile Leu Glu Asp Met Pro Val Asp Pro Asp 1 5 10 < 210 > 137 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 112 - 122 < 400 > 137 Ile Leu Glu Asp Met Pro Val Asp Pro Asp Asn 1 5 10 < 210 > 138 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 113 - 123 < 400 > 138 Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu 1 5 10 < 210 > 139 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 114 - 124 < 400 > 139 Glu Asp Met Pro Val Asp Pro Asp Asn Glu Ala 1 5 10 < 210 > 140 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 115 - 125 < 400 > 140 Asp Met Pro Val Asp Pro Asp Asn Glu Ala Tyr 1 5 10 < 210 > 141 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 116 - 126 < 400 > 141 Met Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu 1 5 10 < 210 > 142 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 117 - 127 < 400 > 142 Pro Val Asp Pro Asp Asn Glu Ala Tyr Glu Met 1 5 10 < 210 > 143 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 118 - 128 < 400 > 143 Val Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro 1 5 10 < 210 > 144 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 119 - 129 < 400 > 144 Asp Pro Asp Asn Glu Ala Tyr Glu Met Pro Ser 1 5 10 < 210 > 145 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 120 - 130 < 400 > 145 Pro Asp Asn Glu Ala Tyr Glu Met Pro Ser Glu 1 5 10 < 210 > 146 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 121 - 131 < 400 > 146 Asp Asn Glu Ala Tyr Glu Met Pro Ser Glu Glu 1 5 10 < 210 > 147 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 122 - 132 < 400 > 147 Asn Glu Ala Tyr Glu Met Pro Ser Glu Glu Gly 1 5 10 < 210 > 148 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 123 - 133 < 400 > 148 Glu Ala Tyr Glu Met Pro Ser Glu Glu Gly Tyr 1 5 10 < 210 > 149 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 124 - 134 < 400 > 149 Ala Tyr Glu Met Pro Ser Glu Glu Gly Tyr Gln 1 5 10 < 210 > 150 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 125 - 135 < 400 > 150 Tyr Glu Met Pro Ser Glu Glu Gly Tyr Gln Asp 1 5 10 < 210 > 151 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 126 - 136 < 400 > 151 Glu Met Pro Ser Glu Glu Gly Tyr Gln Asp Tyr 1 5 10 < 210 > 152 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 127 - 137 < 400 > 152 Met Pro Ser Glu Glu Gly Tyr Gln Asp Tyr Glu 1 5 10 < 210 > 153 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 128 - 138 < 400 > 153 Pro Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro 1 5 10 < 210 > 154 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 129 - 139 < 400 > 154 Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu 1 5 10 < 210 > 155 < 211 > 11 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Synthetic : alpha - Syn 130 - 140 < 400 > 155 Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu Ala 1 5 10 < 210 > 156 < 211 > 33 < 212 > PRT < 213 > Mus musculus < 220 > < 221 > misc _ feature < 223 > mouse alpha - Syn 111 - 140 peptide in Table 4 < 400 > 156 Arg Arg Arg Gly Ile Leu Glu Asp Met Pro Val Asp Pro Gly Ser Glu 1 5 10 15 Ala Tyr Glu Met Pro Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu 20 25 30 Ala < 210 > 157 < 211 > 33 < 212 > PRT < 213 > Rattus sp . < 220 > < 221 > misc _ feature < 223 > rat alpha - Syn 111 - 140 peptide in Table 4 < 400 > 157 Arg Arg Arg Gly Ile Leu Glu Asp Met Pro Val Asp Pro Ser Ser Glu 1 5 10 15 Ala Tyr Glu Met Pro Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu 20 25 30 Ala < 210 > 158 < 211 > 33 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > misc _ feature < 223 > human alpha - Syn 111 - 140 peptide in Table 4 < 400 > 158 Arg Arg Arg Gly Ile Leu Glu Asp Met Pro Val Asp Pro Asp Asn Glu 1 5 10 15 Ala Tyr Glu Met Pro Ser Glu Glu Gly Tyr Gln Asp Tyr Glu Pro Glu 20 25 30 Ala < 210 > 159 < 211 > 1392 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 - T 93 A - IgG 1 . 3 HC DNA < 400 > 159 atgagggctt ggatcttctt tctgctctgc ctggccggga gagcgctcgc acaggtgcag 60 ctgcaggagt cgggcccagg actggtgaag ccttcggaga ccctgtccct cacctgcact 120 gtctctggtg gctccgtcag cagtggtcgt tactactgga gctggattcg gcagccccca 180 gggaagggac tggagtggat tgggtatatc tattacagtg ggagaaccaa gtacaacccc 240 tccctcaaga gtcgagtcac catatcagta gacacgtcca agaaccagtt ctccctgaag 300 ctgagctctg tgaccgctgc ggacacggcc gtgtattact gtgcgagaga gagggggtac 360 cttgactact ggggccaggg aaccctggtc accgtctcct cagctagcac caagggccca 420 tcggtcttcc ccctggcacc ctcctccaag agcacctctg ggggcacagc ggccctgggc 480 tgcctggtca aggactactt ccccgaaccg gtgacggtgt cgtggaactc aggcgccctg 540 accagcggcg tgcacacctt cccggctgtc ctacagtcct caggactcta ctccctcagc 600 agcgtggtga ccgtgccctc cagcagcttg ggcacccaga cctacatctg caacgtgaat 660 cacaagccca gcaacaccaa ggtggacaag agagttgagc ccaaatcttg tgacaaaact 720 cacacatgcc caccgtgccc agcacctgaa gccgaagggg ccccgtcagt cttcctcttc 780 cccccaaaac ccaaggacac cctcatgatc tcccggaccc ctgaggtcac atgcgtggtg 840 gtggacgtga gccacgaaga ccctgaggtc aagttcaact ggtacgtgga cggcgtggag 900 gtgcataatg ccaagacaaa gccgcgggag gagcagtaca acagcacgta ccgtgtggtc 960 agcgtcctca ccgtcctgca ccaggactgg ctgaatggca aggagtacaa gtgcaaggtc 1020 tccaacaaag ccctcccagc ccccatcgag aaaaccatct ccaaagccaa agggcagccc 1080 cgagaaccac aggtgtacac cctgccccca tcccgggagg agatgaccaa gaaccaggtc 1140 agcctgacct gcctggtcaa aggcttctat cccagcgaca tcgccgtgga gtgggagagc 1200 aatgggcagc cggagaacaa ctacaagacc acgcctcccg tgctggactc cgacggctcc 1260 ttcttcctct atagcaagct caccgtggac aagagcaggt ggcagcaggg gaacgtcttc 1320 tcatgctccg tgatgcatga ggctctgcac aaccactaca cgcagaagag cctctccctg 1380 tccccgggtt ga 1392 < 210 > 160 < 211 > 699 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 - LC DNA ( for both 7 A 10 and 7 A 10 - T 93 A ) ; same LC sequence shared with 21 A 3 and 15 A 5 < 400 > 160 atgagggctt ggatcttctt tctgctctgc ctggccgggc gcgccttggc cgaaattgtg 60 ttgacgcagt ctccaggcac cctgtctttg tctccagggg aaagagccac cctctcctgc 120 agggccagtc agagtgttag cagcagctac ttagcctggt accagcagaa acctggccag 180 gctcccaggc tcctcatcta tggtgcatcc agcagggcca ctggcatccc agacaggttc 240 agtggcagtg ggtctgggac agacttcact ctcaccatca gcagactgga gcctgaagat 300 tttgcagtgt attactgtca gcagtatggt agctcaccgc tcactttcgg cggagggacc 360 aaggtggaga tcaaacgtac ggtggctgca ccatctgtct tcatcttccc gccatctgat 420 gagcagttga aatctggaac tgcctctgtt gtgtgcctgc tgaataactt ctatcccaga 480 gaggccaaag tacagtggaa ggtggataac gccctccaat cgggtaactc ccaggagagt 540 gtcacagagc aggacagcaa ggacagcacc tacagcctca gcagcaccct gacgctgagc 600 aaagcagact acgagaaaca caaagtctac gcctgcgaag tcacccatca gggcctgagc 660 tcgcccgtca caaagagctt caacagggga gagtgttag 699 < 210 > 161 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 VH DNA < 400 > 161 caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccgtcagc agtggtcgtt actactggag ctggatccgg 120 cagcccccag ggaagggact ggagtggatt gggtatatct attacagtgg gagaaccaag 180 tacaacccct ccctcaagag tcgagtcacc atatcagtag acacgtccaa gaaccagttc 240 tccctgaagc tgagctctgt gaccgctgcg gacacggccg tgtattactg tacgagagag 300 agggggtacc ttgactactg gggccaggga accctggtca ccgtctcctc a 351 < 210 > 162 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 VL DNA ( for both 7 A 10 and 7 A 10 - T 93 A ) ; same VL sequence shared with 21 A 3 and 15 A 5 < 400 > 162 gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgct cactttcggc 300 ggagggacca aggtggagat caaa 324 < 210 > 163 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 7 A 10 - T 93 A VH DNA < 400 > 163 caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccgtcagc agtggtcgtt actactggag ctggattcgg 120 cagcccccag ggaagggact ggagtggatt gggtatatct attacagtgg gagaaccaag 180 tacaacccct ccctcaagag tcgagtcacc atatcagtag acacgtccaa gaaccagttc 240 tccctgaagc tgagctctgt gaccgctgcg gacacggccg tgtattactg tgcgagagag 300 agggggtacc ttgactactg gggccaggga accctggtca ccgtctcctc a 351 < 210 > 164 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 21 A 3 VH DNA < 400 > 164 caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccgtcagc aatcgtaatt actactggag ctggatccgg 120 cagcccccag ggaagggact ggagtggatt gggtatatct attacagtgg gaggaccaag 180 tacaacccct ccctcaagag tcgagtcacc atatcagtag acacgtccaa gaaccagttc 240 tccctgaagg tgagctctgt gaccgctgcg gacacggccg tgtattactg tgcgagagag 300 agggggcggt ttgactactg gggccaggga accctggtca ccgtctcctc a 351 < 210 > 165 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 21 A 3 VL DNA < 400 > 165 gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgct cactttcggc 300 ggagggacca aggtggagat caaa 324 < 210 > 166 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 1 E 8 VL DNA < 400 > 166 gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacctct cactttcggc 300 ggagggacca aggtggagat caaa 324 < 210 > 167 < 211 > 360 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 2 E 2 VH DNA < 400 > 167 caggtgcagc tggtggagtc tgggggaggc gtggtccagc ctgggaggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt agctatgcta tgcactgggt ccgccaggct 120 ccaggcaagg ggctggagtg ggtggcagtt atatcatatg atggaagcaa taaatactac 180 gcagactccg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240 ctgcaaatga acagcctgag agctgaggac acggctgtgt attactgtgc gagaaggggt 300 tcggggagtt attataactt tgactactgg ggccagggaa ccctggtcac cgtctcctca 360 < 210 > 168 < 211 > 321 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 2 E 2 VL DNA < 400 > 168 gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacccac cttcggccaa 300 gggacacgac tggagattaa a 321 < 210 > 169 < 211 > 339 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 23 H 8 VH DNA < 400 > 169 gaggtgcagc tggtggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60 tcctgtgcag cctctggatt caccttcagt agctatggca tgaactgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtttcatac attagtagta gtagtagtac catatactac 180 gcagactctg tgaagggccg attcaccatc tccagagaca atgccaagaa ctcactgtat 240 ctgcaaatga acagcctgag agacgaggac acggctgtgt attactgtgc taactgggga 300 tcctactggg gccagggaac cctggtcacc gtctcctca 339 < 210 > 170 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 23 H 8 VL 1 DNA < 400 > 170 gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agaagctact tagcctggta ccagcagaaa 120 cttggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacctct cactttcggc 300 ggagggacca aggtggagat caaa 324 < 210 > 171 < 211 > 318 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 23 H 8 VL 2 DNA < 400 > 171 gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gggtgttagc agctacttag cctggtacca gcagaaacct 120 ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc 180 aggttcagtg gcagtgggcc tgggacagac ttcactctca ccatcagcag cctagagcct 240 gaagattttg cagtttatta ctgtcagcag cgtagcaact ggcatacttt cggcggaggg 300 accaaggtgg agatcaaa 318 < 210 > 172 < 211 > 321 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 23 H 8 VL 3 DNA < 400 > 172 gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcacccac tttcggcgga 300 gggaccaagg tggagatcaa a 321 < 210 > 173 < 211 > 345 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 11 H 11 VH DNA < 400 > 173 gaggttcagc tggtgcagtc tgggggaggc ttggtacatc ctggggggtc cctgagactc 60 tcctgtgcag gctctggatt caccttcagt agctatgcta tgcactgggt tcgccaggct 120 ccaggaaaag gtctggagtg ggtatcagct attggtactg gtggtggcac atactatgca 180 gactccgtga agggccgatt caccatctcc agagacaatg ccaagaactc cttgtatctt 240 caaatgaaca gcctgagagc cgaggacatg gctgtgtatt actgtgcaag agggaactgg 300 gaatttgact actggggcca gggaaccctg gtcaccgtct cctca 345 < 210 > 174 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 11 H 11 VL 1 DNA < 400 > 174 gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccatt cactttcggc 300 cctgggacca aagtggatat caaa 324 < 210 > 175 < 211 > 315 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 11 H 11 VL 2 DNA < 400 > 175 gccatccagt tgacccagtc tccatcctcc ctgtctgcat ctgtaggaga cagagtcacc 60 atcacttgcc gggcaagtca gggcattagc agtgctttag cctggtatca gcagaaacca 120 gggaaagctc ctaaggtccc gatctatgat gcctccagtt tggaaagtgg ggtcccatca 180 aggttcagcg gcagtggatc tgggacagat ttcactctca ccatcagcag cctgcagcct 240 gaagatcttg caacttatta ctgtcaacag tttaatagtt accctttcgg cggagggacc 300 aaggtggaga tcaaa 315 < 210 > 176 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 15 A 5 VH DNA < 400 > 176 caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccgtcagc agtggtagtt actactggtg ctggatccgg 120 cagcccccag ggaagggact ggagtggatc gggtatatct attacagtgg gcgcaccaag 180 tacaacccct ccctcaagag tcgagtcacc atatcagtag acacgtccaa gaaccagttc 240 tccctgaagc tgagctctgt gaccgctgcg gacacggccg tgtattactg tgcgagagag 300 agggggcggt ttgactactg gggccaggga accctggtca ccgtctcctc a 351 < 210 > 177 < 211 > 324 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 15 A 5 VL DNA < 400 > 177 gaaattgtgt tgacgcagtc tccaggcacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agcagctact tagcctggta ccagcagaaa 120 cctggccagg ctcccaggct cctcatctat ggtgcatcca gcagggccac tggcatccca 180 gacaggttca gtggcagtgg gtctgggaca gacttcactc tcaccatcag cagactggag 240 cctgaagatt ttgcagtgta ttactgtcag cagtatggta gctcaccgct cactttcggc 300 ggagggacca aggtggagat caaa 324 < 210 > 178 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 36 A 3 VH DNA < 400 > 178 caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccgtcagc agtggtagtt actactggag ctggatccgg 120 cagcccccag ggaagggact ggagtggatt gggtatatct attacagtgg gagaaccaag 180 tacaacccct ccctcaagag tcgagtcacc atatcagtag acacgtccag gaaccagttc 240 tccctgaagc tgagctctgt gaccgctgcg gacacggccg tgtattactg tgcgagagag 300 aggggctggc tcgacccctg gggccaggga accctggtca ccgtctcctc a 351 < 210 > 179 < 211 > 317 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 36 A 3 VL DNA < 400 > 179 gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct 120 ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc 180 aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct 240 gaagattttg cagtttatta ctgtcagcag cgtagcaact ggtcaccttc ggccaaggga 300 cacgactgga gattaaa 317 < 210 > 180 < 211 > 342 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 44 B 11 VH DNA < 400 > 180 gaggtgcagt tggtggagtc tggaggaggc ttgatccagc ctggggggtc cctgagactc 60 tcctgtgcag cctctgggtt caccgtcagt agcaaataca tgagctgggt ccgccaggct 120 ccagggaagg ggctggagtg ggtctcagtt atgtatagcg gtggtagaag atactatgca 180 gactccgtga agggccgatt caccatctcc agagacaatt ccaagaacac gctgtatctt 240 caaatgaaca gcctgagagc cgaggacacg gccgtgtatt actgtgcgag aggggatcgg 300 ggtgactact ggggccaggg aaccctggtc accgtctcct ca 342 < 210 > 181 < 211 > 321 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 44 B 11 VL DNA < 400 > 181 gaaattgtgt tgacacagtc tccagccacc ctgtctttgt ctccagggga aagagccacc 60 ctctcctgca gggccagtca gagtgttagc agctacttag cctggtacca acagaaacct 120 ggccaggctc ccaggctcct catctatgat gcatccaaca gggccactgg catcccagcc 180 aggttcagtg gcagtgggtc tgggacagac ttcactctca ccatcagcag cctagagcct 240 gaagattttg cagtttatta ctgtcagcag cgtagcaact ggccgatcac cttcggccaa 300 gggacacgac tggagattaa a 321 < 210 > 182 < 211 > 351 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic : 1 E 8 VH DNA < 400 > 182 caggtgcagc tgcaggagtc gggcccagga ctggtgaagc cttcggagac cctgtccctc 60 acctgcactg tctctggtgg ctccgtcagc agtggtagtt actactggag ctggatccgg 120 cagcccccag ggaagggact ggagtggatt gggtatatct attacagtgg gagaaccaag 180 tacaacccct ccctcaagag tcgagtcacc atatcagtag acacgtccaa gaaccagttc 240 tccctgaagc tgaggtctgt gaccgctgcg gacacggccg tgtattactg tgtgagagag 300 aggggctggt tcgacccctg gggccaggga accctggtca ccgtctcctc a 351