< 110 > Gwangju Institute of Science and Technology < 120 > A DNA APTAMER SPECIFICALLY BIDING TO SEVERE FEVER WITH THROMBOCYTOPENIA SYNDROME VIRUS AND AND IMMUNOASSAY USING THE APTAMER < 130 > Pn - 2019 - 0085 < 160 > 13 < 170 > KoPatentIn 3 . 0 < 210 > 1 < 211 > 245 < 212 > PRT < 213 > Artificial Sequence < 220 > < 223 > Severe fever with thrombocytopenia virus N protein < 400 > 1 Met Ser Glu Trp Ser Arg Ile Ala Val Glu Phe Gly Glu Gln Gln Leu 1 5 10 15 Asn Leu Thr Glu Leu Glu Asp Phe Ala Arg Glu Leu Ala Tyr Glu Gly 20 25 30 Leu Asp Pro Ala Leu Ile Ile Lys Lys Leu Lys Glu Thr Gly Gly Asp 35 40 45 Asp Trp Val Lys Asp Thr Lys Phe Ile Ile Val Phe Ala Leu Thr Arg 50 55 60 Gly Asn Lys Ile Val Lys Ala Ser Gly Lys Met Ser Asn Ser Gly Ser 65 70 75 80 Lys Arg Leu Met Ala Leu Gln Glu Lys Tyr Gly Leu Val Glu Arg Ala 85 90 95 Glu Thr Arg Leu Ser Ile Thr Pro Val Arg Val Ala Gln Ser Leu Pro 100 105 110 Thr Trp Thr Cys Ala Ala Ala Ala Ala Leu Lys Glu Tyr Leu Pro Val 115 120 125 Gly Pro Ala Val Met Asn Leu Lys Val Glu Asn Tyr Pro Pro Glu Met 130 135 140 Met Cys Met Ala Phe Gly Ser Leu Ile Pro Thr Ala Gly Val Ser Glu 145 150 155 160 Ala Thr Thr Lys Thr Leu Met Glu Ala Tyr Ser Leu Trp Gln Asp Ala 165 170 175 Phe Thr Lys Thr Ile Asn Val Lys Met Arg Gly Ala Ser Lys Thr Glu 180 185 190 Val Tyr Asn Ser Phe Arg Asp Pro Leu His Ala Ala Val Asn Ser Val 195 200 205 Phe Phe Pro Asn Asp Val Arg Val Lys Trp Leu Lys Ala Lys Gly Ile 210 215 220 Leu Gly Pro Asp Gly Val Pro Ser Arg Ala Ala Glu Val Ala Ala Ala 225 230 235 240 Ala Tyr Arg Asn Leu 245 < 210 > 2 < 211 > 76 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Synthetic ( Nucleic acid construct ) < 220 > < 221 > misc _ feature < 222 > ( 19 ) . .( 58 ) < 223 > each n is A , T , U , G or C < 400 > 2 atccagagtg acgcagcann nnnnnnnnnn nnnnnnnnnn nnnnnnnnnn nnnnnnnntg 60 gacacggtgg cttagt 76 < 210 > 3 < 211 > 40 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > aptamer core sequence < 400 > 3 cgaccacaga ttggagactg atagtgcacg agcaaggaca 40 < 210 > 4 < 211 > 40 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > aptamer core sequence < 400 > 4 tcggatggat tgtggtcgaa gttgtttccg acactagtca 40 < 210 > 5 < 211 > 40 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > aptamer core sequence < 400 > 5 cacatcggag aacaggcgca ctgtcggagg aaccgcaacg 40 < 210 > 6 < 211 > 76 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Severe fever with thrombocytopenia virus NP aptamer 1 full sequence < 400 > 6 atccagagtg acgcagcacg accacagatt ggagactgat agtgcacgag caaggacatg 60 gacacggtgg cttagt 76 < 210 > 7 < 211 > 76 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Severe fever with thrombocytopenia virus NP aptamer 2 full sequence < 400 > 7 atccagagtg acgcagcatc ggatggattg tggtcgaagt tgtttccgac actagtcatg 60 gacacggtgg cttagt 76 < 210 > 8 < 211 > 76 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Severe fever with thrombocytopenia virus NP aptamer 3 full sequence < 400 > 8 atccagagtg acgcagcaca catcggagaa caggcgcact gtcggaggaa ccgcaacgtg 60 gacacggtgg cttagt 76 < 210 > 9 < 211 > 76 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Influenza A NP aptamer < 400 > 9 tagggaagag aaggacatat gatggcgtac ggggatgagg tgatcgtagt gggttgacta 60 gtacatgacc acttga 76 < 210 > 10 < 211 > 80 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Influenza B NP aptamer < 400 > 10 attatggcgt ttgcagcgtt ctggttggtg gtggtgatag gtggggggaa ggagggtatc 60 ttgttggtga ggtaacggct 80 < 210 > 11 < 211 > 82 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > human immunodeficiency virus ( HIV ) p 24 aptamer < 400 > 11 agatactgcc attcattgca tcgagcacgc gactgatgag gatggtctag tagctggggt 60 cgagtactaa gctatgtgtc ga 82 < 210 > 12 < 211 > 85 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > Ebola NP aptamer < 400 > 12 gatgtgagtg acgtggatcg agcggatgtg aaggctgaaa gtggctttgg gcggtcgtaa 60 gtgtcacaga gcatgcaaca agacc 85 < 210 > 13 < 211 > 76 < 212 > DNA < 213 > Artificial Sequence < 220 > < 223 > SARS - CoV - 2 NP aptamer < 400 > 13 atccagagtg acgcagcaaa cccaagcaaa ctacctctat acccttcgac cttcatcatg 60 gacacggtgg cttagt 76