That heavily depends on the rune itself . Like , that question is so complicated . For early game , whatever is cheap and really good is what you should go with if it ' s a rune you absolutely cannot pass up for example , a purple slot 2 6 star speed rune with HP , att , and crit rate on it or something equally ridiculous . I would not recommend buying endgame runes like Rage , Will , Nemesis , Vampire , etc . because they ' re extremely expensive and you won ' t be able to get more of them consistently for a VEEEERY long time I have been playing for a year and a half and still don ' t have an NB 10 team , so I don ' t have Rage , Vamp , Will , or Nem runes in large quantities yet . <| sep |> To be fair , your smartphone offered me a happy few minutes while I played Doctorstroh Jigsaw . I knew there was some sensible advice in there somewhere p