화합물 144 - E 2 LC / MS ESI 483 ( M + H ) +. 1 H NMR ( 500 MHz , MeOD ) δ 7 . 82 ( dd , J = 7 . 6 , 1 . 8 Hz , 1 H ) , 7 . 41 ( dd , J = 7 . 8 , 1 . 2 Hz , 1 H ) , 7 . 32 ? 7 . 15 ( m , 2 H ) , 7 . 16 ( d , J = 7 . 3 Hz , 1 H ) , 6 . 37 ( d , J = 7 . 3 Hz , 1 H ) , 4 . 52 ( s , 1 H ) , 3 . 47 ( d , J = 9 . 3 Hz , 1 H ) , 3 . 42 ? 3 . 35 ( m , 4 H ) , 2 . 99 ( s , 1 H ) , 2 . 87 ? 2 . 74 ( m , 3 H ) , 2 . 72 ( t , J = 6 . 2 Hz , 2 H ) , 2 . 49 ( d , J = 6 . 9 Hz , 2 H ) , 2 . 37 ( s , 1 H ) , 2 . 22 ( s , 1 H ) , 2 . 04 ( d , J = 12 . 7 Hz , 1 H ) , 1 . 94 ? 1 . 82 ( m , 7 H ) , 1 . 76 ? 1 . 68 ( m , 1 H ) , 1 . 49 ? 1 . 42 ( m , 2 H ) . 키 랄 SFC I ( 50 % EtOH ) : ee 100 %, Rt = 11 . 00 분 .