40 2019 43 권 6 호 
 39 2019 43 권 6 호 
 38 2019 43 권 6 호 
 37 2019 43 권 6 호 
 36 2019 43 권 6 호 
 35 2019 43 권 5 호 
 34 2019 43 권 5 호 
 33 2019 43 권 5 호 
 32 2019 43 권 5 호 
 저 출력 초음파 와 기계 적 장력 이 MG - 56 세포 의 골모 세포 분화 에 미치 는 영향 
 저자 최용식 , 금동호 , 황대석 , 유미현 , 김규 천 , 김욱규 
 Tissue engineering has been rapidly developed in oral and maxillofacial reconstruction . Biocompatible scaffold from chemically composites seeded with stem cells is essential and several growth factors for bone formation and angiogenesis are also required . To overcome limited activity of new bone formation with scaffolds , several biomechanical stimulation methods on cells have been made to grow cells in scaffold . Several bioreactors have been developed for real tissue growth in culture laboratory . In addition to biological stimulants like BMP , growth factors and exogenous drugs , biomechanical stimulation technique has also been known as an effective method in cell differentiation . We developed our own bioreactor with tensile mechanical strains . Then we tested with it for detection of suitable biomechanical effect on the cell differentiation and proliferation . And we also compared the results with the effect of low intensity pulsed ultrasound ( LIPUS ) . Mechanical strain group showed more rapid reaction with cell differentiation and proliferation than non - mechanical strain group . Mechanical strain groups stimulated with 0 . 5 ∼ 0 . 7 Hz for 6 hours and 8 hours showed more active cell differentiation than the group with 0 . 5 ∼ 0 . 7 Hz for 2 . 5 hours tensile strain stimulation . Group of LIPUS also showed more rapid reaction in cell differentiation and proliferation . LIPUS with 3 MHz showed more cell reaction than the LIPUS group with 1 MHz . Our results showed the positive effect on differentiation and proliferation of cell with mechanical tensile strain , LIPUS both . Key words : Osteogenic activity , Tensile strain , Low intensity pulsed ultrasound 
 31 2019 43 권 5 호 
 생약 복합 추출물 의 인간 골수 유래 중 간엽 줄기세포 에서 의 골 분화 에 미치 는 영향 
 저자 김다솔 , 성기수 , 박민 성 , 김민경 , 박경은 , 곽연 주 , 윤 금정 , 김형준 , 배 문경 , 배수경 , 장혜옥 
 Herbal medicine has been the basis for medical treatments through much of human history , and such traditional medicine is still widely practiced today . Modern medicine makes use of many plant - derived compounds as the basis for pharmaceutical drugs . In traditionally , Achyranthes aspera , Safflower ( Carthamus tinctorius ) seed and Acanthopanax senticosus have been used for the treatment and prevention of bone - related diseases . In this study , we investigated the pharmacological effect of mixture of Achyranthes aspera , Safflower ( Carthamus tinctorius ) seed and Acanthopanax senticosus and the other herbs . Two types of enzymes were used to enhance the extraction components of amino acid , mineral content , free sugar , and flavor recovery in extracting natural herbal mixtures ( NME ) . We evaluated regulation of osteogenic differentiation in human bone marrow mesenchymal stem cells using alkaline phosphatase staining , alizarin red S staining and RT - PCR . The CCK - 8 assay indicated that NME had no cytotoxicity but increased cell survival . In addition , NME promoted the mineralization and expression of osteogenic differention marker genes in human bone marrow mesenchymal stem cells . Therefore , NME has an effect of promoting proliferation and osteogenic differentiation of human mesenchymal stem cell . Key words : NME extract , Human bone - marrow mesenchymal stem cells , Osteogenic differentiation , APA 
 30 2019 43 권 5 호 
 점액 선 암종 에 대한 체계 적 고찰 과 증 계 보 고 : 림프절 전이 가 점액선 암종 의 예후 를 결정 할 수 있 는가 ? 
 저자 장태환 , 박 윤하 , 조남표 , 임대호 
 Mucinous adenocarcinoma ( MAC ) refers to a malignant neoplasm that belongs to a subtype of adenocarcinoma which produces mucin . The World Health Organization has classified MAC as a tumor of salivary gland origin and it is extremely rare . Therefore , its characteristics are not well - known . This study reports a case of MAC of minor salivary gland origin , which occurred in the oral commissure of an 82 - year - old female patient , and a systematic review on existing cases of MAC of salivary origin . Based on the study ’ s findings , it is safe to assume that the occurrence of lymph node metastasis is an important factor in determining the prognosis of patients with MAC . Key words : Mucinous adenocarcinoma , Lymphatic metastasis , Prognosis 
 29 2019 43 권 5 호 
 하악골 에 발생 한 국소 백악 - 골 형성 이상 : 외상 성 골 낭과 동반 한 증례 
 저자 김기태 , 신경수 , 최은주 , 윤정훈 
 Benign fibro - osseous lesions are demonstrated as a group of conditions , which normal bone is replaced by a connective tissue matrix that gradually develops cemento - osseous tissue and include developmental lesion , reactive lesion , dysplasia and tumor . Cemento - osseous dysplasia is one of benign fibro - osseous lesions , which is non - neoplastic process . Histologic features of cemento - osseous dysplasia are admixtures of bone and cementoid materials in a fibrous stroma . Cemento - osseous dysplasia associated with traumatic bone cysts has infrequently been reported . Traumatic bone cyst is a pseudocyst that may befound in both the jaws and the long bones . Though blockage of interstitial fluid drainage orvenous obstruction may be the cause of traumatic bone cyst , the exact pathogenesis of traumatic bone cysts is unknown . Melrose et al . was the first to report association of cemento - osseous dysplasia and traumatic bone cystsin their series . It is assumed that different mechanism is involved in cyst formation in these cases . This report presents review of literature and describes a case of focal cemento - osseous dysplasia associated with traumatic bone cyst of the mandible and its surgical treatment . Key words : Traumatic bone cyst , Cemento - osseous dysplasia , Mandible