theres a lot of stuff to adapt to when thinking which combo would be the most efficient , ill name some . 1 . what escapes does the enemy have ? 2 . how fast can I kill him 3 . do I have to get out after killing him ? 4 . how much resourcesflash ult etc are worth using for that kill 5 . how reliable can I execute that combo ? 6 . is there any way I can get interrupted while performing it ? so , this covers some of the questions you should ask yourself when ur used to it this will only take a couple of seconds . for example , you are on midlane in a 5 v 5 fight , theres a fed caitlynn with flash up and a janna with ult as support . the rest of the team isnt particularly close to those 2 . my combo of choice would probably be the shy combo 37 s or the nid . jr combo . te 95 Jo 7 Cn 8 first important thing , you need to hit both of them with your stun otherwise janna will just ult you away . you should watch out for janna shield and bait it out if possible . other combos that wouldnt be that good in that scenario are E R F Q 3 AA W R 2 H too much reactiontime for janna and caitE R W AA R 2 Q cait and janna would never get that close to you in the first placeR E H F R Q WR E R F AA W QE R AA W Q AA R Qtheres a shit ton more but those are a couple of decent ones