I did upgrade and finally ascended two days ago and installed similar mobo MSI Z 170 A sli plus . Some advice Put your ram sticks in 2 nd and 4 th slot , counting from the leftinstalling ram in 2 nd slot is MANDATORY , second stick goes to 4 th slot because dual channel pairs them as dimm 2 dimm 4 and dimm 1 dimm 3 . Make sure that 24 pin plug is seated correctly in JPWR 2 socket and additional 8 pin 12 V in JPWR 1 socket . Check if your power SW plug connects right pins in JFP 1 connector it should be connected to pins # 6 and # 8 . Put you GPU in in the upper PCIe slot , because lower one works with only x 4 speed , not x 16 . Check if you ' re using correct cables plugged in the right slots in your PSU they ' re all named , but somehow I tried to use PCIe 8 pin for cpu power for 15 minutes . EDIT Looks like your PSU have TWO power switches , I know it sounds stupid , but check if both of them are set to ON . EDIT 2 Formatting .