After some trial and error , I currently take Zoloft and Wellbutrin SR and it ' s working for me . I initially took just Zoloft , but it made me a zombie and messed with my ability to orgasm sorry if TMI . Then , because my psych did not communicate very clearly , I switched from Zoloft to Wellbutrin XL . Between going off the Zoloft coldturkey and adding Wellbutrin , those ended up being some of the worst few weeks of my life . I couldn ' t sleep , and when I did , I had bouts of sleep paralysis . I was also deeply depressed , anxious and suicidal for the first time in quite a while . Part of me knew it had something to do with the medication , but that was little consolation from getting no sleep and having intense mood swings and panic attacks . I also take Ritalin , which I imagine didn ' t help the anxiety . Now I am back on the Zoloft and Wellbutrin SR as opposed to the XL , so the stimulating effects of the Wellbutrin are mostly out of my system by the end of the day . I ' ve learned that it ' s better for me to take the Zoloft at night to avoid the zombie effect , and I take the Wellbutrin and Ritalin in the morning . That combination works exceedingly well for me I still get stressed and anxious , but it doesn ' t feel as deep and physical as it used to . It ' s also a lot easier for me to stop myself from ruminating about negative things rather than dwell on negative thoughts and letting them spiral , I can feel that emotion and let the thought pass . Between the medication and regular therapy , I finally feel like I ' m gaining control of my anxietydepressionself esteem issues . Medication has put me in a much better position to work on my skills , and it ' s been so worth the journey of finding the right combination for me .