SEQUENCE LISTING < 110 > Probiodrug AG < 120 > NOVEL INHIBITORS < 130 > IPA 191130 - DE < 150 > GB 1705263 . 0 < 151 > 2017 - 03 - 31 < 160 > 20 < 170 > PatentIn version 3 . 5 < 210 > 1 < 211 > 42 < 212 > PRT < 213 > Homo sapiens < 400 > 1 Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 1 5 10 15 Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 20 25 30 Gly Leu Met Val Gly Gly Val Val Ile Ala 35 40 < 210 > 2 < 211 > 40 < 212 > PRT < 213 > Homo sapiens < 400 > 2 Asp Ala Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys 1 5 10 15 Leu Val Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile 20 25 30 Gly Leu Met Val Gly Gly Val Val 35 40 < 210 > 3 < 211 > 40 < 212 > PRT < 213 > Homo sapiens < 400 > 3 Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val 1 5 10 15 Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu 20 25 30 Met Val Gly Gly Val Val Ile Ala 35 40 < 210 > 4 < 211 > 38 < 212 > PRT < 213 > Homo sapiens < 400 > 4 Glu Phe Arg His Asp Ser Gly Tyr Glu Val His His Gln Lys Leu Val 1 5 10 15 Phe Phe Ala Glu Asp Val Gly Ser Asn Lys Gly Ala Ile Ile Gly Leu 20 25 30 Met Val Gly Gly Val Val 35 < 210 > 5 < 211 > 17 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MOD _ RES < 222 > ( 17 ) . .( 17 ) < 223 > AMIDATION < 400 > 5 Gln Gly Pro Trp Leu Glu Glu Glu Glu Glu Ala Tyr Gly Trp Met Asp 1 5 10 15 Phe < 210 > 6 < 211 > 13 < 212 > PRT < 213 > Homo sapiens < 400 > 6 Gln Leu Tyr Glu Asn Lys Pro Arg Arg Pro Tyr Ile Leu 1 5 10 < 210 > 7 < 211 > 10 < 212 > PRT < 213 > Homo sapiens < 220 > < 221 > MOD _ RES < 222 > ( 10 ) . .( 10 ) < 223 > AMIDATION < 400 > 7 Gln His Trp Ser Tyr Gly Leu Arg Pro Gly 1 5 10 < 210 > 8 < 211 > 97 < 212 > PRT < 213 > Homo sapiens < 400 > 8 Gln Pro Lys Val Pro Glu Trp Val Asn Thr Pro Ser Thr Cys Cys Leu 1 5 10 15 Lys Tyr Tyr Glu Lys Val Leu Pro Arg Arg Leu Val Val Gly Tyr Arg 20 25 30 Lys Ala Leu Asn Cys His Leu Pro Ala Ile Ile Phe Val Thr Lys Arg 35 40 45 Asn Arg Glu Val Cys Thr Asn Pro Asn Asp Asp Trp Val Gln Glu Tyr 50 55 60 Ile Lys Asp Pro Asn Leu Pro Leu Leu Pro Thr Arg Asn Leu Ser Thr 65 70 75 80 Val Lys Ile Ile Thr Ala Lys Asn Gly Gln Pro Gln Leu Leu Asn Ser 85 90 95 Gln < 210 > 9 < 211 > 76 < 212 > PRT < 213 > Homo sapiens < 400 > 9 Gln Pro Asp Ser Val Ser Ile Pro Ile Thr Cys Cys Phe Asn Val Ile 1 5 10 15 Asn Arg Lys Ile Pro Ile Gln Arg Leu Glu Ser Tyr Thr Arg Ile Thr 20 25 30 Asn Ile Gln Cys Pro Lys Glu Ala Val Ile Phe Lys Thr Lys Arg Gly 35 40 45 Lys Glu Val Cys Ala Asp Pro Lys Glu Arg Trp Val Arg Asp Ser Met 50 55 60 Lys His Leu Asp Gln Ile Phe Gln Asn Leu Lys Pro 65 70 75 < 210 > 10 < 211 > 76 < 212 > PRT < 213 > Homo sapiens < 400 > 10 Gln Pro Asp Ala Ile Asn Ala Pro Val Thr Cys Cys Tyr Asn Phe Thr 1 5 10 15 Asn Arg Lys Ile Ser Val Gln Arg Leu Ala Ser Tyr Arg Arg Ile Thr 20 25 30 Ser Ser Lys Cys Pro Lys Glu Ala Val Ile Phe Lys Thr Ile Val Ala 35 40 45 Lys Glu Ile Cys Ala Asp Pro Lys Gln Lys Trp Val Gln Asp Ser Met 50 55 60 Asp His Leu Asp Lys Gln Thr Gln Thr Pro Lys Thr 65 70 75 < 210 > 11 < 211 > 68 < 212 > PRT < 213 > Homo sapiens < 400 > 11 Gln Val Gly Thr Asn Lys Glu Leu Cys Cys Leu Val Tyr Thr Ser Trp 1 5 10 15 Gln Ile Pro Gln Lys Phe Ile Val Asp Tyr Ser Glu Thr Ser Pro Gln 20 25 30 Cys Pro Lys Pro Gly Val Ile Leu Leu Thr Lys Arg Gly Arg Gln Ile 35 40 45 Cys Ala Asp Pro Asn Lys Lys Trp Val Gln Lys Tyr Ile Ser Asp Leu 50 55 60 Lys Leu Asn Ala 65 < 210 > 12 < 211 > 373 < 212 > PRT < 213 > Homo sapiens < 400 > 12 Gln His His Gly Val Thr Lys Cys Asn Ile Thr Cys Ser Lys Met Thr 1 5 10 15 Ser Lys Ile Pro Val Ala Leu Leu Ile His Tyr Gln Gln Asn Gln Ala 20 25 30 Ser Cys Gly Lys Arg Ala Ile Ile Leu Glu Thr Arg Gln His Arg Leu 35 40 45 Phe Cys Ala Asp Pro Lys Glu Gln Trp Val Lys Asp Ala Met Gln His 50 55 60 Leu Asp Arg Gln Ala Ala Ala Leu Thr Arg Asn Gly Gly Thr Phe Glu 65 70 75 80 Lys Gln Ile Gly Glu Val Lys Pro Arg Thr Thr Pro Ala Ala Gly Gly 85 90 95 Met Asp Glu Ser Val Val Leu Glu Pro Glu Ala Thr Gly Glu Ser Ser 100 105 110 Ser Leu Glu Pro Thr Pro Ser Ser Gln Glu Ala Gln Arg Ala Leu Gly 115 120 125 Thr Ser Pro Glu Leu Pro Thr Gly Val Thr Gly Ser Ser Gly Thr Arg 130 135 140 Leu Pro Pro Thr Pro Lys Ala Gln Asp Gly Gly Pro Val Gly Thr Glu 145 150 155 160 Leu Phe Arg Val Pro Pro Val Ser Thr Ala Ala Thr Trp Gln Ser Ser 165 170 175 Ala Pro His Gln Pro Gly Pro Ser Leu Trp Ala Glu Ala Lys Thr Ser 180 185 190 Glu Ala Pro Ser Thr Gln Asp Pro Ser Thr Gln Ala Ser Thr Ala Ser 195 200 205 Ser Pro Ala Pro Glu Glu Asn Ala Pro Ser Glu Gly Gln Arg Val Trp 210 215 220 Gly Gln Gly Gln Ser Pro Arg Pro Glu Asn Ser Leu Glu Arg Glu Glu 225 230 235 240 Met Gly Pro Val Pro Ala His Thr Asp Ala Phe Gln Asp Trp Gly Pro 245 250 255 Gly Ser Met Ala His Val Ser Val Val Pro Val Ser Ser Glu Gly Thr 260 265 270 Pro Ser Arg Glu Pro Val Ala Ser Gly Ser Trp Thr Pro Lys Ala Glu 275 280 285 Glu Pro Ile His Ala Thr Met Asp Pro Gln Arg Leu Gly Val Leu Ile 290 295 300 Thr Pro Val Pro Asp Ala Gln Ala Ala Thr Arg Arg Gln Ala Val Gly 305 310 315 320 Leu Leu Ala Phe Leu Gly Leu Leu Phe Cys Leu Gly Val Ala Met Phe 325 330 335 Thr Tyr Gln Ser Leu Gln Gly Cys Pro Arg Lys Met Ala Gly Glu Met 340 345 350 Ala Glu Gly Leu Arg Tyr Ile Pro Arg Ser Cys Gly Ser Asn Ser Tyr 355 360 365 Val Leu Val Pro Val 370 < 210 > 13 < 211 > 76 < 212 > PRT < 213 > Homo sapiens < 400 > 13 Gln Pro Val Gly Ile Asn Thr Ser Thr Thr Cys Cys Tyr Arg Phe Ile 1 5 10 15 Asn Lys Lys Ile Pro Lys Gln Arg Leu Glu Ser Tyr Arg Arg Thr Thr 20 25 30 Ser Ser His Cys Pro Arg Glu Ala Val Ile Phe Lys Thr Lys Leu Asp 35 40 45 Lys Glu Ile Cys Ala Asp Pro Thr Gln Lys Trp Val Gln Asp Phe Met 50 55 60 Lys His Leu Asp Lys Lys Thr Gln Thr Pro Lys Leu 65 70 75 < 210 > 14 < 211 > 33 < 212 > PRT < 213 > Homo sapiens < 400 > 14 Gln Pro Leu Pro Asp Cys Cys Arg Gln Lys Thr Cys Ser Cys Arg Leu 1 5 10 15 Tyr Glu Leu Leu His Gly Ala Gly Asn His Ala Ala Gly Ile Leu Thr 20 25 30 Leu < 210 > 15 < 211 > 11 < 212 > PRT < 213 > Homo sapiens < 400 > 15 Arg Pro Lys Pro Gln Gln Phe Phe Gly Leu Met 1 5 10 < 210 > 16 < 211 > 32 < 212 > PRT < 213 > Artificial sequence < 220 > < 223 > Synthetic peptide < 400 > 16 Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser 1 5 10 15 Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val Ile Ala 20 25 30 < 210 > 17 < 211 > 30 < 212 > PRT < 213 > Artificial sequence < 220 > < 223 > Synthetic peptide < 400 > 17 Glu Val His His Gln Lys Leu Val Phe Phe Ala Glu Asp Val Gly Ser 1 5 10 15 Asn Lys Gly Ala Ile Ile Gly Leu Met Val Gly Gly Val Val 20 25 30 < 210 > 18 < 211 > 34 < 212 > PRT < 213 > Artificial sequence < 220 > < 223 > Synthetic peptide < 400 > 18 Glu Ala Ser Asn Cys Phe Ala Ile Arg His Phe Glu Asn Lys Phe Ala 1 5 10 15 Val Glu Thr Leu Ile Cys Ser Arg Thr Val Lys Lys Asn Ile Ile Glu 20 25 30 Glu Asn < 210 > 19 < 211 > 34 < 212 > PRT < 213 > Artificial sequence < 220 > < 223 > Synthetic peptide < 400 > 19 Glu Ala Ser Asn Cys Phe Ala Ile Arg His Phe Glu Asn Lys Phe Ala 1 5 10 15 Val Glu Thr Leu Ile Cys Phe Asn Leu Phe Leu Asn Ser Gln Glu Lys 20 25 30 His Tyr < 210 > 20 < 211 > 5 < 212 > PRT < 213 > Artificial sequence < 220 > < 223 > Synthetic peptide < 400 > 20 Gln Tyr Asn Ala Asp 1 5