< 110 > InnoPharmaScreen Inc . < 120 > Protein differentially expressed by angiogenin and detecting method thereof < 160 > 16 < 170 > KopatentIn 1 . 71 < 210 > 1 < 211 > 928 < 212 > PRT < 213 > Homo sapiens < 400 > 1 Met Pro Pro Lys Thr Pro Arg Lys Thr Ala Ala Thr Ala Ala Ala Ala 1 5 10 15 Ala Ala Glu Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Glu Glu Asp 20 25 30 Pro Glu Gln Asp Ser Gly Pro Glu Asp Leu Pro Leu Val Arg Leu Glu 35 40 45 Phe Glu Glu Thr Glu Glu Pro Asp Phe Thr Ala Leu Cys Gln Lys Leu 50 55 60 Lys Ile Pro Asp His Val Arg Glu Arg Ala Trp Leu Thr Trp Glu Lys 65 70 75 80 Val Ser Ser Val Asp Gly Val Leu Gly Gly Tyr Ile Gln Lys Lys Lys 85 90 95 Glu Leu Trp Gly Ile Cys Ile Phe Ile Ala Ala Val Asp Leu Asp Glu 100 105 110 Met Ser Phe Thr Phe Thr Glu Leu Gln Lys Asn Ile Glu Ile Ser Val 115 120 125 His Lys Phe Phe Asn Leu Leu Lys Glu Ile Asp Thr Ser Thr Lys Val 130 135 140 Asp Asn Ala Met Ser Arg Leu Leu Lys Lys Tyr Asp Val Leu Phe Ala 145 150 155 160 Leu Phe Ser Lys Leu Glu Arg Thr Cys Glu Leu Ile Tyr Leu Thr Gln 165 170 175 Pro Ser Ser Ser Ile Ser Thr Glu Ile Asn Ser Ala Leu Val Leu Lys 180 185 190 Val Ser Trp Ile Thr Phe Leu Leu Ala Lys Gly Glu Val Leu Gln Met 195 200 205 Glu Asp Asp Leu Val Ile Ser Phe Gln Leu Met Leu Cys Val Leu Asp 210 215 220 Tyr Phe Ile Lys Leu Ser Pro Pro Met Leu Leu Lys Glu Pro Tyr Lys 225 230 235 240 Thr Ala Val Ile Pro Ile Asn Gly Ser Pro Arg Thr Pro Arg Arg Gly 245 250 255 Gln Asn Arg Ser Ala Arg Ile Ala Lys Gln Leu Glu Asn Asp Thr Arg 260 265 270 Ile Ile Glu Val Leu Cys Lys Glu His Glu Cys Asn Ile Asp Glu Val 275 280 285 Lys Asn Val Tyr Phe Lys Asn Phe Ile Pro Phe Met Asn Ser Leu Gly 290 295 300 Leu Val Thr Ser Asn Gly Leu Pro Glu Val Glu Asn Leu Ser Lys Arg 305 310 315 320 Tyr Glu Glu Ile Tyr Leu Lys Asn Lys Asp Leu Asp Ala Arg Leu Phe 325 330 335 Leu Asp His Asp Lys Thr Leu Gln Thr Asp Ser Ile Asp Ser Phe Glu 340 345 350 Thr Gln Arg Thr Pro Arg Lys Ser Asn Leu Asp Glu Glu Val Asn Val 355 360 365 Ile Pro Pro His Thr Pro Val Arg Thr Val Met Asn Thr Ile Gln Gln 370 375 380 Leu Met Met Ile Leu Asn Ser Ala Ser Asp Gln Pro Ser Glu Asn Leu 385 390 395 400 Ile Ser Tyr Phe Asn Asn Cys Thr Val Asn Pro Lys Glu Ser Ile Leu 405 410 415 Lys Arg Val Lys Asp Ile Gly Tyr Ile Phe Lys Glu Lys Phe Ala Lys 420 425 430 Ala Val Gly Gln Gly Cys Val Glu Ile Gly Ser Gln Arg Tyr Lys Leu 435 440 445 Gly Val Arg Leu Tyr Tyr Arg Val Met Glu Ser Met Leu Lys Ser Glu 450 455 460 Glu Glu Arg Leu Ser Ile Gln Asn Phe Ser Lys Leu Leu Asn Asp Asn 465 470 475 480 Ile Phe His Met Ser Leu Leu Ala Cys Ala Leu Glu Val Val Met Ala 485 490 495 Thr Tyr Ser Arg Ser Thr Ser Gln Asn Leu Asp Ser Gly Thr Asp Leu 500 505 510 Ser Phe Pro Trp Ile Leu Asn Val Leu Asn Leu Lys Ala Phe Asp Phe 515 520 525 Tyr Lys Val Ile Glu Ser Phe Ile Lys Ala Glu Gly Asn Leu Thr Arg 530 535 540 Glu Met Ile Lys His Leu Glu Arg Cys Glu His Arg Ile Met Glu Ser 545 550 555 560 Leu Ala Trp Leu Ser Asp Ser Pro Leu Phe Asp Leu Ile Lys Gln Ser 565 570 575 Lys Asp Arg Glu Gly Pro Thr Asp His Leu Glu Ser Ala Cys Pro Leu 580 585 590 Asn Leu Pro Leu Gln Asn Asn His Thr Ala Ala Asp Met Tyr Leu Ser 595 600 605 Pro Val Arg Ser Pro Lys Lys Lys Gly Ser Thr Thr Arg Val Asn Ser 610 615 620 Thr Ala Asn Ala Glu Thr Gln Ala Thr Ser Ala Phe Gln Thr Gln Lys 625 630 635 640 Pro Leu Lys Ser Thr Ser Leu Ser Leu Phe Tyr Lys Lys Val Tyr Arg 645 650 655 Leu Ala Tyr Leu Arg Leu Asn Thr Leu Cys Glu Arg Leu Leu Ser Glu 660 665 670 His Pro Glu Leu Glu His Ile Ile Trp Thr Leu Phe Gln His Thr Leu 675 680 685 Gln Asn Glu Tyr Glu Leu Met Arg Asp Arg His Leu Asp Gln Ile Met 690 695 700 Met Cys Ser Met Tyr Gly Ile Cys Lys Val Lys Asn Ile Asp Leu Lys 705 710 715 720 Phe Lys Ile Ile Val Thr Ala Tyr Lys Asp Leu Pro His Ala Val Gln 725 730 735 Glu Thr Phe Lys Arg Val Leu Ile Lys Glu Glu Glu Tyr Asp Ser Ile 740 745 750 Ile Val Phe Tyr Asn Ser Val Phe Met Gln Arg Leu Lys Thr Asn Ile 755 760 765 Leu Gln Tyr Ala Ser Thr Arg Pro Pro Thr Leu Ser Pro Ile Pro His 770 775 780 Ile Pro Arg Ser Pro Tyr Lys Phe Pro Ser Ser Pro Leu Arg Ile Pro 785 790 795 800 Gly Gly Asn Ile Tyr Ile Ser Pro Leu Lys Ser Pro Tyr Lys Ile Ser 805 810 815 Glu Gly Leu Pro Thr Pro Thr Lys Met Thr Pro Arg Ser Arg Ile Leu 820 825 830 Val Ser Ile Gly Glu Ser Phe Gly Thr Ser Glu Lys Phe Gln Lys Ile 835 840 845 Asn Gln Met Val Cys Asn Ser Asp Arg Val Leu Lys Arg Ser Ala Glu 850 855 860 Gly Ser Asn Pro Pro Lys Pro Leu Lys Lys Leu Arg Phe Asp Ile Glu 865 870 875 880 Gly Ser Asp Glu Ala Asp Gly Ser Lys His Leu Pro Gly Glu Ser Lys 885 890 895 Phe Gln Gln Lys Leu Ala Glu Met Thr Ser Thr Arg Thr Arg Met Gln 900 905 910 Lys Gln Lys Met Asn Asp Ser Met Asp Thr Ser Asn Lys Glu Glu Lys 915 920 925 < 210 > 2 < 211 > 108 < 212 > PRT < 213 > Homo sapiens < 400 > 2 Met Ala Ala Ala Met Asp Val Asp Thr Pro Ser Gly Thr Asn Ser Gly 1 5 10 15 Ala Gly Lys Lys Arg Phe Glu Val Lys Lys Trp Asn Ala Val Ala Leu 20 25 30 Trp Ala Trp Asp Ile Val Val Asp Asn Cys Ala Ile Cys Arg Asn His 35 40 45 Ile Met Asp Leu Cys Ile Glu Cys Gln Ala Asn Gln Ala Ser Ala Thr 50 55 60 Ser Glu Glu Cys Thr Val Ala Trp Gly Val Cys Asn His Ala Phe His 65 70 75 80 Phe His Cys Ile Ser Arg Trp Leu Lys Thr Arg Gln Val Cys Pro Leu 85 90 95 Asp Asn Arg Glu Trp Glu Phe Gln Lys Tyr Gly His 100 105 < 210 > 3 < 211 > 236 < 212 > PRT < 213 > Homo sapiens < 400 > 3 Met Ala Arg Pro Leu Val Pro Ser Ser Gln Lys Ala Leu Leu Leu Glu 1 5 10 15 Leu Lys Gly Leu Gln Glu Glu Pro Val Glu Gly Phe Arg Val Thr Leu 20 25 30 Val Asp Glu Gly Asp Leu Tyr Asn Trp Glu Val Ala Ile Phe Gly Pro 35 40 45 Pro Asn Thr Tyr Tyr Glu Gly Gly Tyr Phe Lys Ala Arg Leu Lys Phe 50 55 60 Pro Ile Asp Tyr Pro Tyr Ser Pro Pro Ala Phe Arg Phe Leu Thr Lys 65 70 75 80 Met Trp His Pro Asn Ile Tyr Glu Thr Gly Asp Val Cys Ile Ser Ile 85 90 95 Leu His Pro Pro Val Asp Asp Pro Gln Ser Gly Glu Leu Pro Ser Glu 100 105 110 Arg Trp Asn Pro Thr Gln Asn Val Arg Thr Ile Leu Leu Ser Val Ile 115 120 125 Ser Leu Leu Asn Glu Pro Asn Thr Phe Ser Pro Ala Asn Val Asp Ala 130 135 140 Ser Val Met Tyr Arg Lys Trp Lys Glu Ser Lys Gly Lys Asp Arg Glu 145 150 155 160 Tyr Thr Asp Ile Ile Arg Lys Gln Val Leu Gly Thr Lys Val Asp Ala 165 170 175 Glu Arg Asp Gly Val Lys Val Pro Thr Thr Leu Ala Glu Tyr Cys Val 180 185 190 Lys Thr Lys Ala Pro Ala Pro Asp Glu Gly Ser Asp Leu Phe Tyr Asp 195 200 205 Asp Tyr Tyr Glu Asp Gly Glu Val Glu Glu Glu Ala Asp Ser Cys Phe 210 215 220 Gly Asp Asp Glu Asp Asp Ser Gly Thr Glu Glu Ser 225 230 235 < 210 > 4 < 211 > 770 < 212 > PRT < 213 > Homo sapiens < 400 > 4 Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 1 5 10 15 Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 20 25 30 Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 35 40 45 Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 50 55 60 Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 65 70 75 80 His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 85 90 95 Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 100 105 110 Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 115 120 125 Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 130 135 140 Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 145 150 155 160 Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 165 170 175 Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 180 185 190 Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 195 200 205 Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 210 215 220 Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 225 230 235 240 Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 245 250 255 Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 260 265 270 Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 275 280 285 Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 290 295 300 Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 305 310 315 320 Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 325 330 335 Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 340 345 350 Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 355 360 365 Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 370 375 380 Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 385 390 395 400 Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 405 410 415 Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 420 425 430 Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 435 440 445 Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 450 455 460 Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 465 470 475 480 Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 485 490 495 Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 500 505 510 Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 515 520 525 Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 530 535 540 Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 545 550 555 560 Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 565 570 575 Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 580 585 590 Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 595 600 605 Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 610 615 620 Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 625 630 635 640 Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 645 650 655 Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 660 665 670 Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 675 680 685 Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro 690 695 700 Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn 705 710 715 720 Thr Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln 725 730 735 Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe 740 745 750 Glu Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser 755 760 765 Pro Met 770 < 210 > 5 < 211 > 754 < 212 > PRT < 213 > Homo sapiens < 400 > 5 Met Trp Lys Leu Leu Pro Ala Ala Gly Pro Ala Gly Gly Glu Pro Tyr 1 5 10 15 Arg Leu Leu Thr Gly Val Glu Tyr Val Val Gly Arg Lys Asn Cys Ala 20 25 30 Ile Leu Ile Glu Asn Asp Gln Ser Ile Ser Arg Asn His Ala Val Leu 35 40 45 Thr Ala Asn Phe Ser Val Thr Asn Leu Ser Gln Thr Asp Glu Ile Pro 50 55 60 Val Leu Thr Leu Lys Asp Asn Ser Lys Tyr Gly Thr Phe Val Asn Glu 65 70 75 80 Glu Lys Met Gln Asn Gly Phe Ser Arg Thr Leu Lys Ser Gly Asp Gly 85 90 95 Ile Thr Phe Gly Val Phe Gly Ser Lys Phe Arg Ile Glu Tyr Glu Pro 100 105 110 Leu Val Ala Cys Ser Ser Cys Leu Asp Val Ser Gly Lys Thr Ala Leu 115 120 125 Asn Gln Ala Ile Leu Gln Leu Gly Gly Phe Thr Val Asn Asn Trp Thr 130 135 140 Glu Glu Cys Thr His Leu Val Met Val Ser Val Lys Val Thr Ile Lys 145 150 155 160 Thr Ile Cys Ala Leu Ile Cys Gly Arg Pro Ile Val Lys Pro Glu Tyr 165 170 175 Phe Thr Glu Phe Leu Lys Ala Val Glu Ser Lys Lys Gln Pro Pro Gln 180 185 190 Ile Glu Ser Phe Tyr Pro Pro Leu Asp Glu Pro Ser Ile Gly Ser Lys 195 200 205 Asn Val Asp Leu Ser Gly Arg Gln Glu Arg Lys Gln Ile Phe Lys Gly 210 215 220 Lys Thr Phe Ile Phe Leu Asn Ala Lys Gln His Lys Lys Leu Ser Ser 225 230 235 240 Ala Val Val Phe Gly Gly Gly Glu Ala Arg Leu Ile Thr Glu Glu Asn 245 250 255 Glu Glu Glu His Asn Phe Phe Leu Ala Pro Gly Thr Cys Val Val Asp 260 265 270 Thr Gly Ile Thr Asn Ser Gln Thr Leu Ile Pro Asp Cys Gln Lys Lys 275 280 285 Trp Ile Gln Ser Ile Met Asp Met Leu Gln Arg Gln Gly Leu Arg Pro 290 295 300 Ile Pro Glu Ala Glu Ile Gly Leu Ala Val Ile Phe Met Thr Thr Lys 305 310 315 320 Asn Tyr Cys Asp Pro Gln Gly His Pro Ser Thr Gly Leu Lys Thr Thr 325 330 335 Thr Pro Gly Pro Ser Leu Ser Gln Gly Val Ser Val Asp Glu Lys Leu 340 345 350 Met Pro Ser Ala Pro Val Asn Thr Thr Thr Tyr Val Ala Asp Thr Glu 355 360 365 Ser Glu Gln Ala Asp Thr Trp Asp Leu Ser Glu Arg Pro Lys Glu Ile 370 375 380 Lys Val Ser Lys Met Glu Gln Lys Phe Arg Met Leu Ser Gln Asp Ala 385 390 395 400 Pro Thr Val Lys Glu Ser Cys Lys Thr Ser Ser Asn Asn Asn Ser Met 405 410 415 Val Ser Asn Thr Leu Ala Lys Met Arg Ile Pro Asn Tyr Gln Leu Ser 420 425 430 Pro Thr Lys Leu Pro Ser Ile Asn Lys Ser Lys Asp Arg Ala Ser Gln 435 440 445 Gln Gln Gln Thr Asn Ser Ile Arg Asn Tyr Phe Gln Pro Ser Thr Lys 450 455 460 Lys Arg Glu Arg Asp Glu Glu Asn Gln Glu Met Ser Ser Cys Lys Ser 465 470 475 480 Ala Arg Ile Glu Thr Ser Cys Ser Leu Leu Glu Gln Thr Gln Pro Ala 485 490 495 Thr Pro Ser Leu Trp Lys Asn Lys Glu Gln His Leu Ser Glu Asn Glu 500 505 510 Pro Val Asp Thr Asn Ser Asp Asn Asn Leu Phe Thr Asp Thr Asp Leu 515 520 525 Lys Ser Ile Val Lys Asn Ser Ala Ser Lys Ser His Ala Ala Glu Lys 530 535 540 Leu Arg Ser Asn Lys Lys Arg Glu Met Asp Asp Val Ala Ile Glu Asp 545 550 555 560 Glu Val Leu Glu Gln Leu Phe Lys Asp Thr Lys Pro Glu Leu Glu Ile 565 570 575 Asp Val Lys Val Gln Lys Gln Glu Glu Asp Val Asn Val Arg Lys Arg 580 585 590 Pro Arg Met Asp Ile Glu Thr Asn Asp Thr Phe Ser Asp Glu Ala Val 595 600 605 Pro Glu Ser Ser Lys Ile Ser Gln Glu Asn Glu Ile Gly Lys Lys Arg 610 615 620 Glu Leu Lys Glu Asp Ser Leu Trp Ser Ala Lys Glu Ile Ser Asn Asn 625 630 635 640 Asp Lys Leu Gln Asp Asp Ser Glu Met Leu Pro Lys Lys Leu Leu Leu 645 650 655 Thr Glu Phe Arg Ser Leu Val Ile Lys Asn Ser Thr Ser Arg Asn Pro 660 665 670 Ser Gly Ile Asn Asp Asp Tyr Gly Gln Leu Lys Asn Phe Lys Lys Phe 675 680 685 Lys Lys Val Thr Tyr Pro Gly Ala Gly Lys Leu Pro His Ile Ile Gly 690 695 700 Gly Ser Asp Leu Ile Ala His His Ala Arg Lys Asn Thr Glu Leu Glu 705 710 715 720 Glu Trp Leu Arg Gln Glu Met Glu Val Gln Asn Gln His Ala Lys Glu 725 730 735 Glu Ser Leu Ala Asp Asp Leu Phe Arg Tyr Asn Pro Tyr Leu Lys Arg 740 745 750 Arg Arg < 210 > 6 < 211 > 1638 < 212 > PRT < 213 > Homo sapiens < 400 > 6 Met Ala Ser Pro Ser Pro Ala Asn Ser Pro Met Pro Pro Pro Gln Ala 1 5 10 15 Pro Ser Pro Met Ala Pro Pro Ser Gln Ser Pro Ala Pro Ser Pro His 20 25 30 Ser Pro Tyr Pro His Gln Gln Pro Gly Pro Leu Gln Gly Pro Pro Pro 35 40 45 Pro Gly His Pro Gly Ala Tyr Gly His Pro Met Gln His Gly Pro Pro 50 55 60 Gly Gln Gly Pro Pro Gly His His Met Pro Pro His His Gln Gly Met 65 70 75 80 Ile Phe Ser Lys Gly Pro His Met Gly Met Gln Met Pro Pro Thr Gly 85 90 95 Pro Asn Met Ser Pro Tyr Gln Thr His Gly Met Pro Pro Asn Ala Pro 100 105 110 Thr Gln Pro Cys Ile Val Ser Pro Gly Gly Pro Pro Gly Gly Pro Pro 115 120 125 Pro Pro Glu Arg Ser Ser Gln Glu Asn Leu His Ala Leu Gln Arg Ala 130 135 140 Ile Asp Ser Met Glu Glu Lys Gly Leu Gln Glu Asp Pro Arg Tyr Ser 145 150 155 160 Gln Leu Leu Ala Met Arg Ala Thr Ser Lys His Gln His Leu Asn Gly 165 170 175 Asn Gln Val Asn Leu Leu Arg Thr Gln Ile Thr Ala Tyr Arg Leu Leu 180 185 190 Ala Arg Asn Lys Pro Ile Ser Met Gln Met Gln Gln Ala Leu Gln Ala 195 200 205 Ala Gln Gln Gln Pro Pro Pro Gly Pro Pro Ile Gly Pro Pro Gly Ala 210 215 220 Pro Gly Gly Pro Pro Pro Gly Ser Gln His Ala Gly Gln Pro Pro Val 225 230 235 240 Pro Pro Gln Gln Gln Gln Gln Pro Pro Pro Ser Ala Gly Thr Pro Pro 245 250 255 Gln Cys Ser Thr Pro Pro Ala Ser Asn Pro Tyr Gly Pro Pro Val Pro 260 265 270 Gly Gln Lys Met Gln Val Ala Pro Pro Pro Pro His Met Gln Gln Gly 275 280 285 Gln Pro Leu Pro Pro Gln Pro Pro Gln Val Gly Gly Pro Pro Pro Ile 290 295 300 Gln Gln Gln Gln Pro Pro Gln Gln Gln Gln Gln Gln Ser Gln Pro Pro 305 310 315 320 Pro Pro Glu Pro His Gln His Gln Leu Pro Asn Gly Gly Lys Pro Leu 325 330 335 Ser Met Gly Pro Ser Gly Gly Gln Pro Leu Ile Pro Ser Ser Pro Met 340 345 350 Gln Pro Gln Val Arg Gly Thr Leu Pro Gly Met Pro Pro Gly Ser Gln 355 360 365 Val Pro Gln Pro Gly Gly Gly Pro Gln Arg Gln Val Pro Pro Ala Gly 370 375 380 Met Pro Met Pro Lys Pro Asn Arg Ile Thr Thr Val Ala Lys Pro Val 385 390 395 400 Gly Leu Asp Pro Ile Thr Leu Leu Gln Glu Arg Glu Asn Arg Ile Ala 405 410 415 Ala Arg Ile Ser Leu Arg Met Gln Glu Leu Gln Arg Leu Pro Ala Thr 420 425 430 Met Ser Glu Asp Leu Arg Leu Gln Ala Ala Ile Glu Leu Arg Ala Leu 435 440 445 Arg Val Leu Asn Phe Gln Arg Gln Leu Arg Met Glu Phe Val Gln Cys 450 455 460 Thr Arg Arg Asp Thr Thr Leu Glu Thr Ala Leu Asn Ile Lys Leu Tyr 465 470 475 480 Lys Arg Thr Lys Arg Gln Gly Leu Arg Glu Ala Arg Ala Thr Glu Lys 485 490 495 Leu Glu Lys Gln Gln Lys Leu Glu Ala Glu Arg Lys Arg Arg Gln Lys 500 505 510 His Leu Glu Phe Leu Ala Ala Val Leu Gln His Gly Lys Asp Leu Arg 515 520 525 Glu Phe His Arg Asn Asn Lys Ala Gln Leu Ala Arg Met Asn Lys Ala 530 535 540 Val Met Asn His His Ala Asn Ala Glu Arg Glu Gln Lys Lys Glu Gln 545 550 555 560 Glu Arg Ile Glu Lys Glu Arg Met Arg Arg Leu Met Ala Glu Asp Glu 565 570 575 Glu Gly Tyr Arg Lys Leu Ile Asp Gln Lys Lys Asp Lys Arg Leu Ala 580 585 590 Phe Leu Leu Ser Gln Thr Asp Glu Tyr Ile Ser Asn Leu Thr Gln Met 595 600 605 Val Lys Gln His Lys Asp Asp Gln Met Lys Lys Lys Glu Glu Glu Gly 610 615 620 Lys Arg Leu Ile Gln Phe Lys Lys Glu Leu Leu Met Ser Gly Glu Tyr 625 630 635 640 Ile Gly Ile Asp Glu Gly Ser Ile Val Ala Asp Met Arg Val His Val 645 650 655 Val Glu Gln Cys Thr Gly Lys Lys Leu Thr Gly Asp Asp Ala Pro Met 660 665 670 Leu Lys His Leu His Arg Trp Leu Asn Met His Pro Gly Trp Asp Trp 675 680 685 Ile Asp Asp Glu Glu Asp Ser Cys Gly Ser Asn Asp Asp His Lys Pro 690 695 700 Lys Val Glu Glu Gln Pro Thr Ala Thr Glu Asp Ala Thr Asp Lys Ala 705 710 715 720 Gln Ala Thr Gly Asn Asp Glu Asp Ala Lys Asp Leu Ile Thr Lys Ala 725 730 735 Lys Val Glu Asp Asp Glu Tyr Arg Thr Glu Glu Gln Thr Tyr Tyr Ser 740 745 750 Ile Ala His Thr Ile His Glu Lys Val Val Glu Gln Ala Ser Ile Met 755 760 765 Val Asn Gly Thr Leu Lys Glu Tyr Gln Ile Lys Gly Leu Glu Trp Leu 770 775 780 Val Ser Leu Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met 785 790 795 800 Gly Leu Gly Lys Thr Ile Gln Thr Ile Ser Leu Val Thr Tyr Leu Met 805 810 815 Asp Arg Lys Lys Val Met Gly Pro Tyr Leu Ile Ile Val Pro Leu Ser 820 825 830 Thr Leu Pro Asn Trp Val Leu Glu Phe Glu Lys Trp Ala Pro Ala Val 835 840 845 Gly Val Val Ser Tyr Lys Gly Ser Pro Gln Gly Arg Arg Leu Leu Gln 850 855 860 Asn Gln Met Arg Ala Thr Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu 865 870 875 880 Tyr Val Ile Lys Asp Lys Ala Val Leu Ala Lys Ile Gln Trp Lys Tyr 885 890 895 Met Ile Ile Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu 900 905 910 Thr Gln Val Leu Asn Thr His Tyr Ile Ala Pro Tyr Arg Leu Leu Leu 915 920 925 Thr Gly Thr Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu 930 935 940 Asn Phe Leu Leu Pro Ser Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln 945 950 955 960 Trp Phe Asn Ala Pro Phe Ala Thr Thr Gly Glu Lys Val Glu Leu Asn 965 970 975 Glu Glu Glu Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg 980 985 990 Pro Phe Leu Leu Arg Arg Leu Lys Lys Glu Val Glu His Gln Leu Pro 995 1000 1005 Asp Lys Val Glu Tyr Ile Ile Lys Cys Asp Met Ser Ala Leu Gln Arg 1010 1015 1020 Val Leu Tyr Lys His Met Gln Ser Lys Gly Val Leu Leu Thr Asp Gly 1025 1030 1035 1040 Ser Glu Lys Gly Lys His Gly Lys Gly Gly Ala Lys Ala Leu Met Asn 1045 1050 1055 Thr Ile Val Gln Leu Arg Lys Leu Cys Asn His Pro Phe Met Phe Gln 1060 1065 1070 His Ile Glu Glu Lys Tyr Cys Asp His Thr Gly Gly His Gly Val Val 1075 1080 1085 Ser Gly Pro Asp Leu Tyr Arg Val Ser Gly Lys Phe Glu Leu Leu Asp 1090 1095 1100 Arg Ile Leu Pro Lys Leu Lys Ala Thr Asn His Arg Val Leu Leu Phe 1105 1110 1115 1120 Cys Gln Met Thr Gln Cys Met Thr Ile Ile Glu Asp Tyr Leu Gly Trp 1125 1130 1135 Arg Gln Phe Gly Tyr Leu Arg Leu Asp Gly Thr Thr Lys Ala Glu Asp 1140 1145 1150 Arg Gly Glu Leu Leu Arg Lys Phe Asn Ala Lys Gly Ser Asp Val Phe 1155 1160 1165 Val Phe Leu Leu Ser Thr Arg Ala Gly Gly Leu Gly Leu Asn Leu Gln 1170 1175 1180 Thr Ala Asp Thr Val Val Ile Phe Asp Ser Asp Trp Asn Pro His Gln 1185 1190 1195 1200 Asp Leu Gln Ala Gln Asp Arg Ala His Arg Ile Gly Gln Arg Asn Glu 1205 1210 1215 Val Arg Val Leu Arg Leu Met Thr Val Asn Ser Val Glu Glu Arg Ile 1220 1225 1230 Leu Ala Ala Ala Arg Tyr Lys Leu Asn Met Asp Glu Lys Val Ile Gln 1235 1240 1245 Ala Gly Met Phe Asp Gln Lys Ser Thr Gly Ser Glu Arg Gln Gln Phe 1250 1255 1260 Leu Gln Thr Ile Leu His Gln Asp Asp Asn Glu Glu Glu Glu Glu Asn 1265 1270 1275 1280 Glu Val Pro Asp Asp Glu Met Ile Asn Met Met Ile Ala Arg Ser Glu 1285 1290 1295 Glu Glu Ile Glu Ile Phe Lys Arg Met Asp Ala Glu Arg Lys Lys Glu 1300 1305 1310 Asp Glu Glu Ile His Pro Gly Arg Glu Arg Leu Ile Asp Glu Ser Glu 1315 1320 1325 Leu Pro Asp Trp Leu Thr Lys Asp Asp Asp Glu Val Glu Arg Phe His 1330 1335 1340 Tyr Gln Tyr Asp Glu Asp Thr Ile Leu Gly Arg Gly Ser Arg Gln Arg 1345 1350 1355 1360 Lys Glu Val Asp Tyr Thr Asp Ser Leu Thr Glu Lys Glu Trp Leu Lys 1365 1370 1375 Ala Ile Asp Asp Gly Ala Glu Phe Asp Glu Glu Glu Glu Glu Asp Asp 1380 1385 1390 Ser Lys Arg Lys Arg Arg Lys Arg Lys Asn Arg Lys Glu Glu Ser Asp 1395 1400 1405 Asp Asp Ser Leu Ile Leu Lys Arg Arg Arg Arg Gln Asn Leu Asp Lys 1410 1415 1420 Arg Ser Lys Lys Gln Met His Lys Ile Met Ser Ala Val Ile Lys His 1425 1430 1435 1440 Asn Gln Asp Gly Arg Thr Leu Ser Glu Pro Phe Met Lys Leu Pro Ser 1445 1450 1455 Arg Gln Arg Leu Pro Asp Tyr Tyr Glu Ile Ile Lys Arg Pro Val Asp 1460 1465 1470 Ile Lys Lys Ile Leu Gln Arg Ile Glu Asp Cys Lys Tyr Ala Asp Leu 1475 1480 1485 Asn Glu Leu Glu Lys Asp Phe Met Gln Leu Cys Gln Asn Ala Gln Ile 1490 1495 1500 Tyr Asn Glu Glu Ala Ser Leu Ile Tyr Leu Asp Ser Ile Ala Leu Gln 1505 1510 1515 1520 Lys Val Phe Val Gly Ala Arg Gln Arg Ile Thr Ala Ala Ala Asp Ala 1525 1530 1535 Ala Ala Val Ala Ala Gly Asp Asn Thr Gly Glu Ala His Gly Asn Gly 1540 1545 1550 Gly Ser Asp Asn Ser Asp Asn Asp Asp Asp Asp Gly Gly Asp Asp Gly 1555 1560 1565 Ser Asp Asp Glu Glu Ile Ala Thr Thr Ser Ala Ala Ala Val Lys Met 1570 1575 1580 Lys Leu Lys Leu Asn Lys Ser Leu Ala Ser Ala Pro Ala Thr Pro Thr 1585 1590 1595 1600 Gln Ser Ser Ser Asn Val Ser Ser Gly Ala Ala Thr Thr Ser Lys Lys 1605 1610 1615 Gln Thr Arg Arg Lys Arg Ser Gln Lys Lys Tyr Thr Ile Ser Asp Asp 1620 1625 1630 Asp Asp Asp Asp Met Asp 1635 < 210 > 7 < 211 > 841 < 212 > PRT < 213 > Homo sapiens < 400 > 7 Met Asn Lys Val Arg Asp Ile Lys Asn Lys Phe Lys Asn Glu Asp Leu 1 5 10 15 Thr Asp Glu Leu Ser Leu Asn Lys Ile Ser Ala Asp Thr Thr Asp Asn 20 25 30 Ser Gly Thr Val Asn Gln Ile Met Met Met Ala Asn Asn Pro Glu Asp 35 40 45 Trp Leu Ser Leu Leu Leu Lys Leu Glu Lys Asn Ser Val Pro Leu Ser 50 55 60 Asp Ala Leu Leu Asn Lys Leu Ile Gly Arg Tyr Ser Gln Ala Ile Glu 65 70 75 80 Ala Leu Pro Pro Asp Lys Tyr Gly Gln Asn Glu Ser Phe Ala Arg Ile 85 90 95 Gln Val Arg Phe Ala Glu Leu Lys Ala Ile Gln Glu Pro Asp Asp Ala 100 105 110 Arg Asp Tyr Phe Gln Met Ala Arg Ala Asn Cys Lys Lys Phe Ala Phe 115 120 125 Val His Ile Ser Phe Ala Gln Phe Glu Leu Ser Gln Gly Asn Val Lys 130 135 140 Lys Ser Lys Gln Leu Leu Gln Lys Ala Val Glu Arg Gly Ala Val Pro 145 150 155 160 Leu Glu Met Leu Glu Ile Ala Leu Arg Asn Leu Asn Leu Gln Lys Lys 165 170 175 Gln Leu Leu Ser Glu Glu Glu Lys Lys Asn Leu Ser Ala Ser Thr Val 180 185 190 Leu Thr Ala Gln Glu Ser Phe Ser Gly Ser Leu Gly His Leu Gln Asn 195 200 205 Arg Asn Asn Ser Cys Asp Ser Arg Gly Gln Thr Thr Lys Ala Arg Phe 210 215 220 Leu Tyr Gly Glu Asn Met Pro Pro Gln Asp Ala Glu Ile Gly Tyr Arg 225 230 235 240 Asn Ser Leu Arg Gln Thr Asn Lys Thr Lys Gln Ser Cys Pro Phe Gly 245 250 255 Arg Val Pro Val Asn Leu Leu Asn Ser Pro Asp Cys Asp Val Lys Thr 260 265 270 Asp Asp Ser Val Val Pro Cys Phe Met Lys Arg Gln Thr Ser Arg Ser 275 280 285 Glu Cys Arg Asp Leu Val Val Pro Gly Ser Lys Pro Ser Gly Asn Asp 290 295 300 Ser Cys Glu Leu Arg Asn Leu Lys Ser Val Gln Asn Ser His Phe Lys 305 310 315 320 Glu Pro Leu Val Ser Asp Glu Lys Ser Ser Glu Leu Ile Ile Thr Asp 325 330 335 Ser Ile Thr Leu Lys Asn Lys Thr Glu Ser Ser Leu Leu Ala Lys Leu 340 345 350 Glu Glu Thr Lys Glu Tyr Gln Glu Pro Glu Val Pro Glu Ser Asn Gln 355 360 365 Lys Gln Trp Gln Ala Lys Arg Lys Ser Glu Cys Ile Asn Gln Asn Pro 370 375 380 Ala Ala Ser Ser Asn His Trp Gln Ile Pro Glu Leu Ala Arg Lys Val 385 390 395 400 Asn Thr Glu Gln Lys His Thr Thr Phe Glu Gln Pro Val Phe Ser Val 405 410 415 Ser Lys Gln Ser Pro Pro Ile Ser Thr Ser Lys Trp Phe Asp Pro Lys 420 425 430 Ser Ile Cys Lys Thr Pro Ser Ser Asn Thr Leu Asp Asp Tyr Met Ser 435 440 445 Cys Phe Arg Thr Pro Val Val Lys Asn Asp Phe Pro Pro Ala Cys Gln 450 455 460 Leu Ser Thr Pro Tyr Gly Gln Pro Ala Cys Phe Gln Gln Gln Gln His 465 470 475 480 Gln Ile Leu Ala Thr Pro Leu Gln Asn Leu Gln Val Leu Ala Ser Ser 485 490 495 Ser Ala Asn Glu Cys Ile Ser Val Lys Gly Arg Ile Tyr Ser Ile Leu 500 505 510 Lys Gln Ile Gly Ser Gly Gly Ser Ser Lys Val Phe Gln Val Leu Asn 515 520 525 Glu Lys Lys Gln Ile Tyr Ala Ile Lys Tyr Val Asn Leu Glu Glu Ala 530 535 540 Asp Asn Gln Thr Leu Asp Ser Tyr Arg Asn Glu Ile Ala Tyr Leu Asn 545 550 555 560 Lys Leu Gln Gln His Ser Asp Lys Ile Ile Arg Leu Tyr Asp Tyr Glu 565 570 575 Ile Thr Asp Gln Tyr Ile Tyr Met Val Met Glu Cys Gly Asn Ile Asp 580 585 590 Leu Asn Ser Trp Leu Lys Lys Lys Lys Ser Ile Asp Pro Trp Glu Arg 595 600 605 Lys Ser Tyr Trp Lys Asn Met Leu Glu Ala Val His Thr Ile His Gln 610 615 620 His Gly Ile Val His Ser Asp Leu Lys Pro Ala Asn Phe Leu Ile Val 625 630 635 640 Asp Gly Met Leu Lys Leu Ile Asp Phe Gly Ile Ala Asn Gln Met Gln 645 650 655 Pro Asp Thr Thr Ser Val Val Lys Asp Ser Gln Val Gly Thr Val Asn 660 665 670 Tyr Met Pro Pro Glu Ala Ile Lys Asp Met Ser Ser Ser Arg Glu Asn 675 680 685 Gly Lys Ser Lys Ser Lys Ile Ser Pro Lys Ser Asp Val Trp Ser Leu 690 695 700 Gly Cys Ile Leu Tyr Tyr Met Thr Tyr Gly Lys Thr Pro Phe Gln Gln 705 710 715 720 Ile Ile Asn Gln Ile Ser Lys Leu His Ala Ile Ile Asp Pro Asn His 725 730 735 Glu Ile Glu Phe Pro Asp Ile Pro Glu Lys Asp Leu Gln Asp Val Leu 740 745 750 Lys Cys Cys Leu Lys Arg Asp Pro Lys Gln Arg Ile Ser Ile Pro Glu 755 760 765 Leu Leu Ala His Pro Tyr Val Gln Ile Gln Thr His Pro Val Asn Gln 770 775 780 Met Ala Lys Gly Thr Thr Glu Glu Met Lys Tyr Val Leu Gly Gln Leu 785 790 795 800 Val Gly Leu Asn Ser Pro Asn Ser Ile Leu Lys Ala Ala Lys Thr Leu 805 810 815 Tyr Glu His Tyr Ser Gly Gly Glu Ser His Asn Ser Ser Ser Ser Lys 820 825 830 Thr Phe Glu Lys Lys Arg Gly Lys Lys 835 840 < 210 > 8 < 211 > 303 < 212 > PRT < 213 > Homo sapiens < 400 > 8 Met Ala Thr Ser Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala 1 5 10 15 Tyr Gly Thr Val Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val 20 25 30 Ala Leu Lys Ser Val Arg Val Pro Asn Gly Gly Gly Gly Gly Gly Gly 35 40 45 Leu Pro Ile Ser Thr Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 50 55 60 Ala Phe Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Thr 65 70 75 80 Ser Arg Thr Asp Arg Glu Ile Lys Val Thr Leu Val Phe Glu His Val 85 90 95 Asp Gln Asp Leu Arg Thr Tyr Leu Asp Lys Ala Pro Pro Pro Gly Leu 100 105 110 Pro Ala Glu Thr Ile Lys Asp Leu Met Arg Gln Phe Leu Arg Gly Leu 115 120 125 Asp Phe Leu His Ala Asn Cys Ile Val His Arg Asp Leu Lys Pro Glu 130 135 140 Asn Ile Leu Val Thr Ser Gly Gly Thr Val Lys Leu Ala Asp Phe Gly 145 150 155 160 Leu Ala Arg Ile Tyr Ser Tyr Gln Met Ala Leu Thr Pro Val Val Val 165 170 175 Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu Gln Ser Thr Tyr Ala 180 185 190 Thr Pro Val Asp Met Trp Ser Val Gly Cys Ile Phe Ala Glu Met Phe 195 200 205 Arg Arg Lys Pro Leu Phe Cys Gly Asn Ser Glu Ala Asp Gln Leu Gly 210 215 220 Lys Ile Phe Asp Leu Ile Gly Leu Pro Pro Glu Asp Asp Trp Pro Arg 225 230 235 240 Asp Val Ser Leu Pro Arg Gly Ala Phe Pro Pro Arg Gly Pro Arg Pro 245 250 255 Val Gln Ser Val Val Pro Glu Met Glu Glu Ser Gly Ala Gln Leu Leu 260 265 270 Leu Glu Met Leu Thr Phe Asn Pro His Lys Arg Ile Ser Ala Phe Arg 275 280 285 Ala Leu Gln His Ser Tyr Leu His Lys Asp Glu Gly Asn Pro Glu 290 295 300 < 210 > 9 < 211 > 297 < 212 > PRT < 213 > Homo sapiens < 400 > 9 Met Glu Asp Tyr Thr Lys Ile Glu Lys Ile Gly Glu Gly Thr Tyr Gly 1 5 10 15 Val Val Tyr Lys Gly Arg His Lys Thr Thr Gly Gln Val Val Ala Met 20 25 30 Lys Lys Ile Arg Leu Glu Ser Glu Glu Glu Gly Val Pro Ser Thr Ala 35 40 45 Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Arg His Pro Asn Ile Val 50 55 60 Ser Leu Gln Asp Val Leu Met Gln Asp Ser Arg Leu Tyr Leu Ile Phe 65 70 75 80 Glu Phe Leu Ser Met Asp Leu Lys Lys Tyr Leu Asp Ser Ile Pro Pro 85 90 95 Gly Gln Tyr Met Asp Ser Ser Leu Val Lys Ser Tyr Leu Tyr Gln Ile 100 105 110 Leu Gln Gly Ile Val Phe Cys His Ser Arg Arg Val Leu His Arg Asp 115 120 125 Leu Lys Pro Gln Asn Leu Leu Ile Asp Asp Lys Gly Thr Ile Lys Leu 130 135 140 Ala Asp Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Ile Arg Val Tyr 145 150 155 160 Thr His Glu Val Val Thr Leu Trp Tyr Arg Ser Pro Glu Val Leu Leu 165 170 175 Gly Ser Ala Arg Tyr Ser Thr Pro Val Asp Ile Trp Ser Ile Gly Thr 180 185 190 Ile Phe Ala Glu Leu Ala Thr Lys Lys Pro Leu Phe His Gly Asp Ser 195 200 205 Glu Ile Asp Gln Leu Phe Arg Ile Phe Arg Ala Leu Gly Thr Pro Asn 210 215 220 Asn Glu Val Trp Pro Glu Val Glu Ser Leu Gln Asp Tyr Lys Asn Thr 225 230 235 240 Phe Pro Lys Trp Lys Pro Gly Ser Leu Ala Ser His Val Lys Asn Leu 245 250 255 Asp Glu Asn Gly Leu Asp Leu Leu Ser Lys Met Leu Ile Tyr Asp Pro 260 265 270 Ala Lys Arg Ile Ser Gly Lys Met Ala Leu Asn His Pro Tyr Phe Asn 275 280 285 Asp Leu Asp Asn Gln Ile Lys Lys Met 290 295 < 210 > 10 < 211 > 205 < 212 > PRT < 213 > Homo sapiens < 400 > 10 Met Ala Leu Gln Leu Ser Arg Glu Gln Gly Ile Thr Leu Arg Gly Ser 1 5 10 15 Ala Glu Ile Val Ala Glu Phe Phe Ser Phe Gly Ile Asn Ser Ile Leu 20 25 30 Tyr Gln Arg Gly Ile Tyr Pro Ser Glu Thr Phe Thr Arg Val Gln Lys 35 40 45 Tyr Gly Leu Thr Leu Leu Val Thr Thr Asp Leu Glu Leu Ile Lys Tyr 50 55 60 Leu Asn Asn Val Val Glu Gln Leu Lys Asp Trp Leu Tyr Lys Cys Ser 65 70 75 80 Val Gln Lys Leu Val Val Val Ile Ser Asn Ile Glu Ser Gly Glu Val 85 90 95 Leu Glu Arg Trp Gln Phe Asp Ile Glu Cys Asp Lys Thr Ala Lys Asp 100 105 110 Asp Ser Ala Pro Arg Glu Lys Ser Gln Lys Ala Ile Gln Asp Glu Ile 115 120 125 Arg Ser Val Ile Arg Gln Ile Thr Ala Thr Val Thr Phe Leu Pro Leu 130 135 140 Leu Glu Val Ser Cys Ser Phe Asp Leu Leu Ile Tyr Thr Asp Lys Asp 145 150 155 160 Leu Val Val Pro Glu Lys Trp Glu Glu Ser Gly Pro Gln Phe Ile Thr 165 170 175 Asn Ser Glu Glu Val Arg Leu Arg Ser Phe Thr Thr Thr Ile His Lys 180 185 190 Val Asn Ser Met Val Ala Tyr Lys Ile Pro Val Asn Asp 195 200 205 < 210 > 11 < 211 > 261 < 212 > PRT < 213 > Homo sapiens < 400 > 11 Met Phe Glu Ala Arg Leu Val Gln Gly Ser Ile Leu Lys Lys Val Leu 1 5 10 15 Glu Ala Leu Lys Asp Leu Ile Asn Glu Ala Cys Trp Asp Ile Ser Ser 20 25 30 Ser Gly Val Asn Leu Gln Ser Met Asp Ser Ser His Val Ser Leu Val 35 40 45 Gln Leu Thr Leu Arg Ser Glu Gly Phe Asp Thr Tyr Arg Cys Asp Arg 50 55 60 Asn Leu Ala Met Gly Val Asn Leu Thr Ser Met Ser Lys Ile Leu Lys 65 70 75 80 Cys Ala Gly Asn Glu Asp Ile Ile Thr Leu Arg Ala Glu Asp Asn Ala 85 90 95 Asp Thr Leu Ala Leu Val Phe Glu Ala Pro Asn Gln Glu Lys Val Ser 100 105 110 Asp Tyr Glu Met Lys Leu Met Asp Leu Asp Val Glu Gln Leu Gly Ile 115 120 125 Pro Glu Gln Glu Tyr Ser Cys Val Val Lys Met Pro Ser Gly Glu Phe 130 135 140 Ala Arg Ile Cys Arg Asp Leu Ser His Ile Gly Asp Ala Val Val Ile 145 150 155 160 Ser Cys Ala Lys Asp Gly Val Lys Phe Ser Ala Ser Gly Glu Leu Gly 165 170 175 Asn Gly Asn Ile Lys Leu Ser Gln Thr Ser Asn Val Asp Lys Glu Glu 180 185 190 Glu Ala Val Thr Ile Glu Met Asn Glu Pro Val Gln Leu Thr Phe Ala 195 200 205 Leu Arg Tyr Leu Asn Phe Phe Thr Lys Ala Thr Pro Leu Ser Ser Thr 210 215 220 Val Thr Leu Ser Met Ser Ala Asp Val Pro Leu Val Val Glu Tyr Lys 225 230 235 240 Ile Ala Asp Met Gly His Leu Lys Tyr Tyr Leu Ala Pro Lys Ile Glu 245 250 255 Asp Glu Glu Gly Ser 260 < 210 > 12 < 211 > 1863 < 212 > PRT < 213 > Homo sapiens < 400 > 12 Met Asp Leu Ser Ala Leu Arg Val Glu Glu Val Gln Asn Val Ile Asn 1 5 10 15 Ala Met Gln Lys Ile Leu Glu Cys Pro Ile Cys Leu Glu Leu Ile Lys 20 25 30 Glu Pro Val Ser Thr Lys Cys Asp His Ile Phe Cys Lys Phe Cys Met 35 40 45 Leu Lys Leu Leu Asn Gln Lys Lys Gly Pro Ser Gln Cys Pro Leu Cys 50 55 60 Lys Asn Asp Ile Thr Lys Arg Ser Leu Gln Glu Ser Thr Arg Phe Ser 65 70 75 80 Gln Leu Val Glu Glu Leu Leu Lys Ile Ile Cys Ala Phe Gln Leu Asp 85 90 95 Thr Gly Leu Glu Tyr Ala Asn Ser Tyr Asn Phe Ala Lys Lys Glu Asn 100 105 110 Asn Ser Pro Glu His Leu Lys Asp Glu Val Ser Ile Ile Gln Ser Met 115 120 125 Gly Tyr Arg Asn Arg Ala Lys Arg Leu Leu Gln Ser Glu Pro Glu Asn 130 135 140 Pro Ser Leu Gln Glu Thr Ser Leu Ser Val Gln Leu Ser Asn Leu Gly 145 150 155 160 Thr Val Arg Thr Leu Arg Thr Lys Gln Arg Ile Gln Pro Gln Lys Thr 165 170 175 Ser Val Tyr Ile Glu Leu Gly Ser Asp Ser Ser Glu Asp Thr Val Asn 180 185 190 Lys Ala Thr Tyr Cys Ser Val Gly Asp Gln Glu Leu Leu Gln Ile Thr 195 200 205 Pro Gln Gly Thr Arg Asp Glu Ile Ser Leu Asp Ser Ala Lys Lys Ala 210 215 220 Ala Cys Glu Phe Ser Glu Thr Asp Val Thr Asn Thr Glu His His Gln 225 230 235 240 Pro Ser Asn Asn Asp Leu Asn Thr Thr Glu Lys Arg Ala Ala Glu Arg 245 250 255 His Pro Glu Lys Tyr Gln Gly Ser Ser Val Ser Asn Leu His Val Glu 260 265 270 Pro Cys Gly Thr Asn Thr His Ala Ser Ser Leu Gln His Glu Asn Ser 275 280 285 Ser Leu Leu Leu Thr Lys Asp Arg Met Asn Val Glu Lys Ala Glu Phe 290 295 300 Cys Asn Lys Ser Lys Gln Pro Gly Leu Ala Arg Ser Gln His Asn Arg 305 310 315 320 Trp Ala Gly Ser Lys Glu Thr Cys Asn Asp Arg Arg Thr Pro Ser Thr 325 330 335 Glu Lys Lys Val Asp Leu Asn Ala Asp Pro Leu Cys Glu Arg Lys Glu 340 345 350 Trp Asn Lys Gln Lys Leu Pro Cys Ser Glu Asn Pro Arg Asp Thr Glu 355 360 365 Asp Val Pro Trp Ile Thr Leu Asn Ser Ser Ile Gln Lys Val Asn Glu 370 375 380 Trp Phe Ser Arg Ser Asp Glu Leu Leu Gly Ser Asp Asp Ser His Asp 385 390 395 400 Gly Glu Ser Glu Ser Asn Ala Lys Val Ala Asp Val Leu Asp Val Leu 405 410 415 Asn Glu Val Asp Glu Tyr Ser Gly Ser Ser Glu Lys Ile Asp Leu Leu 420 425 430 Ala Ser Asp Pro His Glu Ala Leu Ile Cys Lys Ser Glu Arg Val His 435 440 445 Ser Lys Ser Val Glu Ser Asn Ile Glu Asp Lys Ile Phe Gly Lys Thr 450 455 460 Tyr Arg Lys Lys Ala Ser Leu Pro Asn Leu Ser His Val Thr Glu Asn 465 470 475 480 Leu Ile Ile Gly Ala Phe Val Thr Glu Pro Gln Ile Ile Gln Glu Arg 485 490 495 Pro Leu Thr Asn Lys Leu Lys Arg Lys Arg Arg Pro Thr Ser Gly Leu 500 505 510 His Pro Glu Asp Phe Ile Lys Lys Ala Asp Leu Ala Val Gln Lys Thr 515 520 525 Pro Glu Met Ile Asn Gln Gly Thr Asn Gln Thr Glu Gln Asn Gly Gln 530 535 540 Val Met Asn Ile Thr Asn Ser Gly His Glu Asn Lys Thr Lys Gly Asp 545 550 555 560 Ser Ile Gln Asn Glu Lys Asn Pro Asn Pro Ile Glu Ser Leu Glu Lys 565 570 575 Glu Ser Ala Phe Lys Thr Lys Ala Glu Pro Ile Ser Ser Ser Ile Ser 580 585 590 Asn Met Glu Leu Glu Leu Asn Ile His Asn Ser Lys Ala Pro Lys Lys 595 600 605 Asn Arg Leu Arg Arg Lys Ser Ser Thr Arg His Ile His Ala Leu Glu 610 615 620 Leu Val Val Ser Arg Asn Leu Ser Pro Pro Asn Cys Thr Glu Leu Gln 625 630 635 640 Ile Asp Ser Cys Ser Ser Ser Glu Glu Ile Lys Lys Lys Lys Tyr Asn 645 650 655 Gln Met Pro Val Arg His Ser Arg Asn Leu Gln Leu Met Glu Gly Lys 660 665 670 Glu Pro Ala Thr Gly Ala Lys Lys Ser Asn Lys Pro Asn Glu Gln Thr 675 680 685 Ser Lys Arg His Asp Ser Asp Thr Phe Pro Glu Leu Lys Leu Thr Asn 690 695 700 Ala Pro Gly Ser Phe Thr Lys Cys Ser Asn Thr Ser Glu Leu Lys Glu 705 710 715 720 Phe Val Asn Pro Ser Leu Pro Arg Glu Glu Lys Glu Glu Lys Leu Glu 725 730 735 Thr Val Lys Val Ser Asn Asn Ala Glu Asp Pro Lys Asp Leu Met Leu 740 745 750 Ser Gly Glu Arg Val Leu Gln Thr Glu Arg Ser Val Glu Ser Ser Ser 755 760 765 Ile Ser Leu Val Pro Gly Thr Asp Tyr Gly Thr Gln Glu Ser Ile Ser 770 775 780 Leu Leu Glu Val Ser Thr Leu Gly Lys Ala Lys Thr Glu Pro Asn Lys 785 790 795 800 Cys Val Ser Gln Cys Ala Ala Phe Glu Asn Pro Lys Gly Leu Ile His 805 810 815 Gly Cys Ser Lys Asp Asn Arg Asn Asp Thr Glu Gly Phe Lys Tyr Pro 820 825 830 Leu Gly His Glu Val Asn His Ser Arg Glu Thr Ser Ile Glu Met Glu 835 840 845 Glu Ser Glu Leu Asp Ala Gln Tyr Leu Gln Asn Thr Phe Lys Val Ser 850 855 860 Lys Arg Gln Ser Phe Ala Pro Phe Ser Asn Pro Gly Asn Ala Glu Glu 865 870 875 880 Glu Cys Ala Thr Phe Ser Ala His Ser Gly Ser Leu Lys Lys Gln Ser 885 890 895 Pro Lys Val Thr Phe Glu Cys Glu Gln Lys Glu Glu Asn Gln Gly Lys 900 905 910 Asn Glu Ser Asn Ile Lys Pro Val Gln Thr Val Asn Ile Thr Ala Gly 915 920 925 Phe Pro Val Val Gly Gln Lys Asp Lys Pro Val Asp Asn Ala Lys Cys 930 935 940 Ser Ile Lys Gly Gly Ser Arg Phe Cys Leu Ser Ser Gln Phe Arg Gly 945 950 955 960 Asn Glu Thr Gly Leu Ile Thr Pro Asn Lys His Gly Leu Leu Gln Asn 965 970 975 Pro Tyr Arg Ile Pro Pro Leu Phe Pro Ile Lys Ser Phe Val Lys Thr 980 985 990 Lys Cys Lys Lys Asn Leu Leu Glu Glu Asn Phe Glu Glu His Ser Met 995 1000 1005 Ser Pro Glu Arg Glu Met Gly Asn Glu Asn Ile Pro Ser Thr Val Ser 1010 1015 1020 Thr Ile Ser Arg Asn Asn Ile Arg Glu Asn Val Phe Lys Glu Ala Ser 1025 1030 1035 1040 Ser Ser Asn Ile Asn Glu Val Gly Ser Ser Thr Asn Glu Val Gly Ser 1045 1050 1055 Ser Ile Asn Glu Ile Gly Ser Ser Asp Glu Asn Ile Gln Ala Glu Leu 1060 1065 1070 Gly Arg Asn Arg Gly Pro Lys Leu Asn Ala Met Leu Arg Leu Gly Val 1075 1080 1085 Leu Gln Pro Glu Val Tyr Lys Gln Ser Leu Pro Gly Ser Asn Cys Lys 1090 1095 1100 His Pro Glu Ile Lys Lys Gln Glu Tyr Glu Glu Val Val Gln Thr Val 1105 1110 1115 1120 Asn Thr Asp Phe Ser Pro Tyr Leu Ile Ser Asp Asn Leu Glu Gln Pro 1125 1130 1135 Met Gly Ser Ser His Ala Ser Gln Val Cys Ser Glu Thr Pro Asp Asp 1140 1145 1150 Leu Leu Asp Asp Gly Glu Ile Lys Glu Asp Thr Ser Phe Ala Glu Asn 1155 1160 1165 Asp Ile Lys Glu Ser Ser Ala Val Phe Ser Lys Ser Val Gln Lys Gly 1170 1175 1180 Glu Leu Ser Arg Ser Pro Ser Pro Phe Thr His Thr His Leu Ala Gln 1185 1190 1195 1200 Gly Tyr Arg Arg Gly Ala Lys Lys Leu Glu Ser Ser Glu Glu Asn Leu 1205 1210 1215 Ser Ser Glu Asp Glu Glu Leu Pro Cys Phe Gln His Leu Leu Phe Gly 1220 1225 1230 Lys Val Asn Asn Ile Pro Ser Gln Ser Thr Arg His Ser Thr Val Ala 1235 1240 1245 Thr Glu Cys Leu Ser Lys Asn Thr Glu Glu Asn Leu Leu Ser Leu Lys 1250 1255 1260 Asn Ser Leu Asn Asp Cys Ser Asn Gln Val Ile Leu Ala Lys Ala Ser 1265 1270 1275 1280 Gln Glu His His Leu Ser Glu Glu Thr Lys Cys Ser Ala Ser Leu Phe 1285 1290 1295 Ser Ser Gln Cys Ser Glu Leu Glu Asp Leu Thr Ala Asn Thr Asn Thr 1300 1305 1310 Gln Asp Pro Phe Leu Ile Gly Ser Ser Lys Gln Met Arg His Gln Ser 1315 1320 1325 Glu Ser Gln Gly Val Gly Leu Ser Asp Lys Glu Leu Val Ser Asp Asp 1330 1335 1340 Glu Glu Arg Gly Thr Gly Leu Glu Glu Asn Asn Gln Glu Glu Gln Ser 1345 1350 1355 1360 Met Asp Ser Asn Leu Gly Glu Ala Ala Ser Gly Cys Glu Ser Glu Thr 1365 1370 1375 Ser Val Ser Glu Asp Cys Ser Gly Leu Ser Ser Gln Ser Asp Ile Leu 1380 1385 1390 Thr Thr Gln Gln Arg Asp Thr Met Gln His Asn Leu Ile Lys Leu Gln 1395 1400 1405 Gln Glu Met Ala Glu Leu Glu Ala Val Leu Glu Gln His Gly Ser Gln 1410 1415 1420 Pro Ser Asn Ser Tyr Pro Ser Ile Ile Ser Asp Ser Ser Ala Leu Glu 1425 1430 1435 1440 Asp Leu Arg Asn Pro Glu Gln Ser Thr Ser Glu Lys Ala Val Leu Thr 1445 1450 1455 Ser Gln Lys Ser Ser Glu Tyr Pro Ile Ser Gln Asn Pro Glu Gly Leu 1460 1465 1470 Ser Ala Asp Lys Phe Glu Val Ser Ala Asp Ser Ser Thr Ser Lys Asn 1475 1480 1485 Lys Glu Pro Gly Val Glu Arg Ser Ser Pro Ser Lys Cys Pro Ser Leu 1490 1495 1500 Asp Asp Arg Trp Tyr Met His Ser Cys Ser Gly Ser Leu Gln Asn Arg 1505 1510 1515 1520 Asn Tyr Pro Ser Gln Glu Glu Leu Ile Lys Val Val Asp Val Glu Glu 1525 1530 1535 Gln Gln Leu Glu Glu Ser Gly Pro His Asp Leu Thr Glu Thr Ser Tyr 1540 1545 1550 Leu Pro Arg Gln Asp Leu Glu Gly Thr Pro Tyr Leu Glu Ser Gly Ile 1555 1560 1565 Ser Leu Phe Ser Asp Asp Pro Glu Ser Asp Pro Ser Glu Asp Arg Ala 1570 1575 1580 Pro Glu Ser Ala Arg Val Gly Asn Ile Pro Ser Ser Thr Ser Ala Leu 1585 1590 1595 1600 Lys Val Pro Gln Leu Lys Val Ala Glu Ser Ala Gln Ser Pro Ala Ala 1605 1610 1615 Ala His Thr Thr Asp Thr Ala Gly Tyr Asn Ala Met Glu Glu Ser Val 1620 1625 1630 Ser Arg Glu Lys Pro Glu Leu Thr Ala Ser Thr Glu Arg Val Asn Lys 1635 1640 1645 Arg Met Ser Met Val Val Ser Gly Leu Thr Pro Glu Glu Phe Met Leu 1650 1655 1660 Val Tyr Lys Phe Ala Arg Lys His His Ile Thr Leu Thr Asn Leu Ile 1665 1670 1675 1680 Thr Glu Glu Thr Thr His Val Val Met Lys Thr Asp Ala Glu Phe Val 1685 1690 1695 Cys Glu Arg Thr Leu Lys Tyr Phe Leu Gly Ile Ala Gly Gly Lys Trp 1700 1705 1710 Val Val Ser Tyr Phe Trp Val Thr Gln Ser Ile Lys Glu Arg Lys Met 1715 1720 1725 Leu Asn Glu His Asp Phe Glu Val Arg Gly Asp Val Val Asn Gly Arg 1730 1735 1740 Asn His Gln Gly Pro Lys Arg Ala Arg Glu Ser Gln Asp Arg Lys Ile 1745 1750 1755 1760 Phe Arg Gly Leu Glu Ile Cys Cys Tyr Gly Pro Phe Thr Asn Met Pro 1765 1770 1775 Thr Asp Gln Leu Glu Trp Met Val Gln Leu Cys Gly Ala Ser Val Val 1780 1785 1790 Lys Glu Leu Ser Ser Phe Thr Leu Gly Thr Gly Val His Pro Ile Val 1795 1800 1805 Val Val Gln Pro Asp Ala Trp Thr Glu Asp Asn Gly Phe His Ala Ile 1810 1815 1820 Gly Gln Met Cys Glu Ala Pro Val Val Thr Arg Glu Trp Val Leu Asp 1825 1830 1835 1840 Ser Val Ala Leu Tyr Gln Cys Gln Glu Leu Asp Thr Tyr Leu Ile Pro 1845 1850 1855 Gln Ile Pro His Ser His Tyr 1860 < 210 > 13 < 211 > 307 < 212 > PRT < 213 > Homo sapiens < 400 > 13 Met Gly Thr Val Leu Ser Leu Ser Pro Ser Tyr Arg Lys Ala Thr Leu 1 5 10 15 Phe Glu Asp Gly Ala Ala Thr Val Gly His Tyr Thr Ala Val Gln Asn 20 25 30 Ser Lys Asn Ala Lys Asp Lys Asn Leu Lys Arg His Ser Ile Ile Ser 35 40 45 Val Leu Pro Trp Lys Arg Ile Val Ala Val Ser Ala Lys Lys Lys Asn 50 55 60 Ser Lys Lys Val Gln Pro Asn Ser Ser Tyr Gln Asn Asn Ile Thr His 65 70 75 80 Leu Asn Asn Glu Asn Leu Lys Lys Ser Leu Ser Cys Ala Asn Leu Ser 85 90 95 Thr Phe Ala Gln Pro Pro Pro Ala Gln Pro Pro Ala Pro Pro Ala Ser 100 105 110 Gln Leu Ser Gly Ser Gln Thr Gly Gly Ser Ser Ser Val Lys Lys Ala 115 120 125 Pro His Pro Ala Val Thr Ser Ala Gly Thr Pro Lys Arg Val Ile Val 130 135 140 Gln Ala Ser Thr Ser Glu Leu Leu Arg Cys Leu Gly Glu Phe Leu Cys 145 150 155 160 Arg Arg Cys Tyr Arg Leu Lys His Leu Ser Pro Thr Asp Pro Val Leu 165 170 175 Trp Leu Arg Ser Val Asp Arg Ser Leu Leu Leu Gln Gly Trp Gln Asp 180 185 190 Gln Gly Phe Ile Thr Pro Ala Asn Val Val Phe Leu Tyr Met Leu Cys 195 200 205 Arg Asp Val Ile Ser Ser Glu Val Gly Ser Asp His Glu Leu Gln Ala 210 215 220 Val Leu Leu Thr Cys Leu Tyr Leu Ser Tyr Ser Tyr Met Gly Asn Glu 225 230 235 240 Ile Ser Tyr Pro Leu Lys Pro Phe Leu Val Glu Ser Cys Lys Glu Ala 245 250 255 Phe Trp Asp Arg Cys Leu Ser Val Ile Asn Leu Met Ser Ser Lys Met 260 265 270 Leu Gln Ile Asn Ala Asp Pro His Tyr Phe Thr Gln Val Phe Ser Asp 275 280 285 Leu Lys Asn Glu Ser Gly Gln Glu Asp Lys Lys Arg Leu Leu Leu Gly 290 295 300 Leu Asp Arg 305 < 210 > 14 < 211 > 317 < 212 > PRT < 213 > Homo sapiens < 400 > 14 Met Phe Gln Ala Ala Glu Arg Pro Gln Glu Trp Ala Met Glu Gly Pro 1 5 10 15 Arg Asp Gly Leu Lys Lys Glu Arg Leu Leu Asp Asp Arg His Asp Ser 20 25 30 Gly Leu Asp Ser Met Lys Asp Glu Glu Tyr Glu Gln Met Val Lys Glu 35 40 45 Leu Gln Glu Ile Arg Leu Glu Pro Gln Glu Val Pro Arg Gly Ser Glu 50 55 60 Pro Trp Lys Gln Gln Leu Thr Glu Asp Gly Asp Ser Phe Leu His Leu 65 70 75 80 Ala Ile Ile His Glu Glu Lys Ala Leu Thr Met Glu Val Ile Arg Gln 85 90 95 Val Lys Gly Asp Leu Ala Phe Leu Asn Phe Gln Asn Asn Leu Gln Gln 100 105 110 Thr Pro Leu His Leu Ala Val Ile Thr Asn Gln Pro Glu Ile Ala Glu 115 120 125 Ala Leu Leu Gly Ala Gly Cys Asp Pro Glu Leu Arg Asp Phe Arg Gly 130 135 140 Asn Thr Pro Leu His Leu Ala Cys Glu Gln Gly Cys Leu Ala Ser Val 145 150 155 160 Gly Val Leu Thr Gln Ser Cys Thr Thr Pro His Leu His Ser Ile Leu 165 170 175 Lys Ala Thr Asn Tyr Asn Gly His Thr Cys Leu His Leu Ala Ser Ile 180 185 190 His Gly Tyr Leu Gly Ile Val Glu Leu Leu Val Ser Leu Gly Ala Asp 195 200 205 Val Asn Ala Gln Glu Pro Cys Asn Gly Arg Thr Ala Leu His Leu Ala 210 215 220 Val Asp Leu Gln Asn Pro Asp Leu Val Ser Leu Leu Leu Lys Cys Gly 225 230 235 240 Ala Asp Val Asn Arg Val Thr Tyr Gln Gly Tyr Ser Pro Tyr Gln Leu 245 250 255 Thr Trp Gly Arg Pro Ser Thr Arg Ile Gln Gln Gln Leu Gly Gln Leu 260 265 270 Thr Leu Glu Asn Leu Gln Met Leu Pro Glu Ser Glu Asp Glu Glu Ser 275 280 285 Tyr Asp Thr Glu Ser Glu Phe Thr Glu Phe Thr Glu Asp Glu Leu Pro 290 295 300 Tyr Asp Asp Cys Val Phe Gly Gly Gln Arg Leu Thr Leu 305 310 315 < 210 > 15 < 211 > 212 < 212 > PRT < 213 > Homo sapiens < 400 > 15 Met Lys Pro Pro Ser Ser Ile Gln Thr Ser Glu Phe Asp Ser Ser Asp 1 5 10 15 Glu Glu Pro Ile Glu Asp Glu Gln Thr Pro Ile His Ile Ser Trp Leu 20 25 30 Ser Leu Ser Arg Val Asn Cys Ser Gln Phe Leu Gly Leu Cys Ala Leu 35 40 45 Pro Gly Cys Lys Phe Lys Asp Val Arg Arg Asn Val Gln Lys Asp Thr 50 55 60 Glu Glu Leu Lys Ser Cys Gly Ile Gln Asp Ile Phe Val Phe Cys Thr 65 70 75 80 Arg Gly Glu Leu Ser Lys Tyr Arg Val Pro Asn Leu Leu Asp Leu Tyr 85 90 95 Gln Gln Cys Gly Ile Ile Thr His His His Pro Ile Ala Asp Gly Gly 100 105 110 Thr Pro Asp Ile Ala Ser Cys Cys Glu Ile Met Glu Glu Leu Thr Thr 115 120 125 Cys Leu Lys Asn Tyr Arg Lys Thr Leu Ile His Cys Tyr Gly Gly Leu 130 135 140 Gly Arg Ser Cys Leu Val Ala Ala Cys Leu Leu Leu Tyr Leu Ser Asp 145 150 155 160 Thr Ile Ser Pro Glu Gln Ala Ile Asp Ser Leu Arg Asp Leu Arg Gly 165 170 175 Ser Gly Ala Ile Gln Thr Ile Lys Gln Tyr Asn Tyr Leu His Glu Phe 180 185 190 Arg Asp Lys Leu Ala Ala His Leu Ser Ser Arg Asp Ser Gln Ser Arg 195 200 205 Ser Val Ser Arg 210 < 210 > 16 < 211 > 499 < 212 > PRT < 213 > Homo sapiens < 400 > 16 Met Ala Gln Phe Ala Phe Glu Ser Asp Leu His Ser Leu Leu Gln Leu 1 5 10 15 Asp Ala Pro Ile Pro Asn Ala Pro Pro Ala Arg Trp Gln Arg Lys Ala 20 25 30 Lys Glu Ala Ala Gly Pro Ala Pro Ser Pro Met Arg Ala Ala Asn Arg 35 40 45 Ser His Ser Ala Gly Arg Thr Pro Gly Arg Thr Pro Gly Lys Ser Ser 50 55 60 Ser Lys Val Gln Thr Thr Pro Ser Lys Pro Gly Gly Asp Arg Tyr Ile 65 70 75 80 Pro His Arg Ser Ala Ala Gln Met Glu Val Ala Ser Phe Leu Leu Ser 85 90 95 Lys Glu Asn Gln Pro Glu Asn Ser Gln Thr Pro Thr Lys Lys Glu His 100 105 110 Gln Lys Ala Trp Ala Leu Asn Leu Asn Gly Phe Asp Val Glu Glu Ala 115 120 125 Lys Ile Leu Arg Leu Ser Gly Lys Pro Gln Asn Ala Pro Glu Gly Tyr 130 135 140 Gln Asn Arg Leu Lys Val Leu Tyr Ser Gln Lys Ala Thr Pro Gly Ser 145 150 155 160 Ser Arg Lys Thr Cys Arg Tyr Ile Pro Ser Leu Pro Asp Arg Ile Leu 165 170 175 Asp Ala Pro Glu Ile Arg Asn Asp Tyr Tyr Leu Asn Leu Val Asp Trp 180 185 190 Ser Ser Gly Asn Val Leu Ala Val Ala Leu Asp Asn Ser Val Tyr Leu 195 200 205 Trp Ser Ala Ser Ser Gly Asp Ile Leu Gln Leu Leu Gln Met Glu Gln 210 215 220 Pro Gly Glu Tyr Ile Ser Ser Val Ala Trp Ile Lys Glu Gly Asn Tyr 225 230 235 240 Leu Ala Val Gly Thr Ser Ser Ala Glu Val Gln Leu Trp Asp Val Gln 245 250 255 Gln Gln Lys Arg Leu Arg Asn Met Thr Ser His Ser Ala Arg Val Gly 260 265 270 Ser Leu Ser Trp Asn Ser Tyr Ile Leu Ser Ser Gly Ser Arg Ser Gly 275 280 285 His Ile His His His Asp Val Arg Val Ala Glu His His Val Ala Thr 290 295 300 Leu Ser Gly His Ser Gln Glu Val Cys Gly Leu Arg Trp Ala Pro Asp 305 310 315 320 Gly Arg His Leu Ala Ser Gly Gly Asn Asp Asn Leu Val Asn Val Trp 325 330 335 Pro Ser Ala Pro Gly Glu Gly Gly Trp Val Pro Leu Gln Thr Phe Thr 340 345 350 Gln His Gln Gly Ala Val Lys Ala Val Ala Trp Cys Pro Trp Gln Ser 355 360 365 Asn Val Leu Ala Thr Gly Gly Gly Thr Ser Asp Arg His Ile Arg Ile 370 375 380 Trp Asn Val Cys Ser Gly Ala Cys Leu Ser Ala Val Asp Ala His Ser 385 390 395 400 Gln Val Cys Ser Ile Leu Trp Ser Pro His Tyr Lys Glu Leu Ile Ser 405 410 415 Gly His Gly Phe Ala Gln Asn Gln Leu Val Ile Trp Lys Tyr Pro Thr 420 425 430 Met Ala Lys Val Ala Glu Leu Lys Gly His Thr Ser Arg Val Leu Ser 435 440 445 Leu Thr Met Ser Pro Asp Gly Ala Thr Val Ala Ser Ala Ala Ala Asp 450 455 460 Glu Thr Leu Arg Leu Trp Arg Cys Phe Glu Leu Asp Pro Ala Arg Arg 465 470 475 480 Arg Glu Arg Glu Lys Ala Ser Ala Ala Lys Ser Ser Leu Ile His Gln 485 490 495 Gly Ile Arg