Characterisation of gender differences throughout peer-review publication process as revealed by thorough analysis of Royal Society of Chemistry submissions, publications and citation data. The Royal Society of Chemistry is committed to investigating and addressing the barriers and biases which face women in the chemical sciences. The cornerstone of this is a thorough analysis of data regarding submissions, review and citations for Royal Society of Chemistry journals from January 2014 until July 2018, since the number and impact of publications and citations are an important factor when seeking research funding and for the progression of academic career. We have applied standard statistical techniques to multiple data sources to perform this analysis, and have investigated whether interactions between variables are significant in affecting various outcomes  in addition to considering variables individually. By considering several different data sources, we found that a baseline of approximately a third of chemistry researchers are female overall, although this differs considerably with Chemistry sub-discipline. Rather than one dominant bias effect, we observe complex interactions and a gradual trickle-down decrease in this female percentage through the publishing process and each of these female percentages is less than the last: authors of submissions; authors of RSC submissions which are not rejected without peer review; authors of accepted RSC publications; authors of cited articles. The success rate for female authors to progress through each of these publishing stages is lower than that for male authors. There is a decreasing female percentage when progressing through from first authors to corresponding authors to reviewers, reflecting the decreasing female percentage with seniority in Chemistry research observed in the “Diversity landscape of the chemical sciences” report. Highlights and actions from this analysis form the basis of an accompanying report to be released from the Royal Society of Chemistry. The “Diversity landscape of the chemical sciences” report,e.g. Elsevier,e.g. Frontiers journals,e.g. eLife,e.g. astronomy.e.g. reviewers and authorsThere have been previous studies into gender influences of science publications.Here we use techniques described in the methodology section to break down and analyse the stages of the publication process by gender for submissions to RSC journals between January 2014 and July 2018 and inter-RSC citations between August 2011 and September 2018. We have divided this manuscript into stages that broadly align to a stage in the publication process. Section A covers the background gender characteristics of chemical science researchers. We then investigate further the subset of those authors who have submitted articles to the Royal Society of Chemistry in Section B. Our submissions undergo an initial pre-screening process to determine their overall suitability for the journal. In this paper, we investigate whether there are gender differences evident in the decision to reject a submission without peer review or to progress it through, and the editors who decide it (Section C). RSC articles undergo single-blind review, so gender characteristics of reviewers are described in Section D, and the review recommendations that they make in Section E. Publication is not the end of the story though, so we look at various gender issues in citation behaviour in Section G, and the long-term effect of these publication and citation imbalances on the gender distribution of living chemists with highest H-index scores in Section H. We will not cover the gender make-up of RSC editorial boards since this was covered in the “Diversity landscape of the chemical sciences report”.1Within each of these sections, there are numbered sub-analyses to explore different facets. Variables investigated include author position (corresponding and first authors are investigated in the greatest detail), corresponding author country, number of submissions, number of authors and submission date. As publishers of the submissions under investigation, it was also possible for us to subset the articles by reviewer gender, number of revisions, editor gender, editorial model of journal, chemistry sub-discipline, and significantly, impact factor of journal for each sub-discipline. The latter displayed significant trends of decreasing female author proportions of submissions and publications with increasing impact factor.p-values are given in the tables of the ESI.For every figure shown in this paper the corresponding numbers plotted, with percentages and confidence intervals, significances and Note that this study reports gender gaps, but has not fully explained their causes. It is more obvious whether bias is the cause of such gaps by conducting experiments which compare multiple reviews of the same research which differ only in their displayed author names and genders, so as to control for other variables, but this was not possible here . It should be noted that one such experiment to investigate race and gender bias in the initial review of NIH grant proposalsWithin this paper, we focus on the technical details of the methodology and analysis. Whilst we make observations, and enter into some basic discussion, wider discussion of the key points and resulting actions are made in an accompanying report to be released by the Royal Society of Chemistry.Here we will describe the techniques, statistical methods applied, and the dataset to which these were applied.The techniques presented were used in two important areas: gender mapping and paper categorisation – as both are important in such studies. The first is important not just for transparency but also because we need to understand the biases that are inherent in gender to name mapping. The second is important since chemistry is not homogeneous and we also need to characterise by different sub-disciplines. We attempted to standardise on techniques and methods and chose statistical methods, which were easy to explain, flexible, and could be visualised. Where possible we used a binominal significance test for simpler analytics. For more in depth consideration of multiple variables we used Generalised Linear Models.via R20The techniques and methods described in this paper were implemented The techniques that we describe are gender name mapping  and article categorisation (since breakdown of results into sub-disciplines was an important consideration).via an in-house R script which performed a simple comparison of each input first name against it to deduce a gender of male, female or unknown. The genders of a test set of first names were calculated and the results manually checked. In addition to manual checking we confirmed that the proportion of female chemistry researchers deduced using gender mapping methods from first name matched the known gender proportion. As a result of this manual checking and validation, we adjusted the list of first names and gender to some extent from its original source, and the reference data set of first names and gender are available at the bitbucket repository linked at the end of this article.A key requirement of this study was to deduce a person's gender for data sources where that information is not directly captured, such as the dataset of authors of RSC submissions. All sources did, however, record their first names and these could be used to infer gender. To infer gender we used a methodology outlined in the “Gender Profiles in UK patenting report”.male, female, mostly_female , mostly_male , unknown or andy .In Section B3 we explore the impact on the scope of this study of using this method by investigating how its results vary with author country, and compare these with an alternative method, the Python-based package “gender-guesser” (version 0.40).We found that both methods gave similar results but that the ONS method gave a better yield of Asian names than gender-guesser. As further validation of our method, in Section A, we found that the ONS method gave similar overall female percentages of chemistry researchers to the results of a dataset where gender was explicitly declared.Analytical; Biological; Catalysis; Chemical Biology and Medicinal; Energy; Environmental; Food; Inorganic; Materials; Nanoscience; Organic; Physical), a document vector was prepared, by selecting by hand terms that the developers considered exemplified the category. Each vector was accompanied by a hand-assigned threshold. To classify a document, a document vector is prepared, and cosine similarities with the vectors for each category are calculated. The document is assigned to those categories where the similarity score exceeds the threshold. In cases where no threshold is exceeded, the paper is assigned to the category it has the highest similarity score for.Our article categorisation system was developed in-house by the RSC in 2013, for the purposes of helping readers to find papers in multi-topic journals, and has been in use in live production since then. It is based on Latent Sematic Analysis.versus those from the categories that the journal belongs to  and generalised linear models for cases with an outcome . Where necessary, in parallel with both of these methods we used T-test calculations to establish whether the difference between weighted means of a variable, e.g. number of submissions per author, were significant for different groups, e.g. female or male, using the t.test function of the R Stats package (v 3.5.1).We used a limited set of statistical methods to try to standardise the analysis given the wide scope defined. We focussed on methods that are standard, easy to use, visualise and understand. We used two main methods – binomial significance test for cases where there is no outcome variable  to be significant. The default confidence interval method was used for simplicity. The calculations were performed using the binom.test function from the stats package (version 3.5.1) in R. The binomial significance test can identify sub-populations where gender proportions fluctuate significantly from the baseline for gender characterisation. It can also identify stages in the publication process that result in a significant change in the female percentage from the baseline, which might be points of concern.This technique was used to derive the significance of differences in proportions seen in sampled populations from a known baseline. The baseline was typically the female proportion of all chemistry researchers but sometimes a more specific one, p < 0.05 indicates significance) using the chisq.test function of the R Stats package (v 3.5.1).While the binomial significance test can highlight stages in the publication that have significantly lower female percentages than the baseline, these fluctuations might have other causes and are not in themselves an indication of gender bias. The calculation of success rates of each stage in the publication process as a function of author gender is a more direct indication of gender disparities. We have calculated the success rate of the different publication stages separately for male and female corresponding authors . A similar technique was previously used in a study of gender diversity in peer review.For more in-depth analyses of the relationship between variables and a binary outcome we used binomial Generalised Linear Model (GLM) models.Furthermore, we present models that partition submissions by journal, chemistry sub-discipline and impact factor to allow gender effects to be observed independent of wide variations across these groups.e.g. impact of journal, submission volumes to journal, number of authors, quality of submission etc.It is important to control for quality of submissions so that the effects of gender are more apparent. We would have liked to have a control for quality from as early on in the publication process as possible, so investigated whether a flag that indicates whether a submissions is single-authored could be used as a proxy for quality of a submission. The reasoning behind this is that single-authored papers: tend to be by established researchers (who do not need to include a supervisor as a co-author); indicate a certain amount of confidence; and avoid any ambiguity of mixed-gender or different-sized teams. However, as we demonstrate in Section C2, there is actually a higher proportion of these single-authored submissions that are rejected without peer review compared to multiple author submissions. This means that this would not be an appropriate quality for control. As an alternative, we considered using the control of reviewer consensus of first round reviews where appropriate since articles that are accepted with reviewer consensus might be expected to be less controversially higher quality papers than those where at least one reviewer suggested either rejection or major revisions. This control would also have the advantage that there are multiple reviews for each article which controls for all other manuscript features glm function from the stats package (version 3.5.1) in R to perform the binomial GLM calculation. This technique allows us to explore the significance of additional variables . We can calculate whether the addition of a variable to a model has significant effect by calculating the Chi square analysis of variance (or deviance) (ANOVA) significance tablesanova function of the stats package (version 3.5.1). GLMs make it relatively simple to study the effects of interactions between, typically categorical, variables. For each model we show plots, equations, Chi-square p-values, and significance. The effect function of the effects package (version 4.0-3) was used to create an output object suitable for plotting with ggplot2 from the GLM model output.We used the multinom function from the nnet package (version 7.3-12) in R. This could be used in a similar way to the binomial GLM model, with one or more input variables. Again, the effect function of the effects package (version 4.0-3) was used to create an output object suitable for plotting with ggplot2 from the GLM model output.Where the outcome is not binomial but has more than two possible values, we have applied a multinomial GLM model which we applied using the The main data set was submission data  regarding all 717 108 articles submitted to RSC journals from January 2014 until July 2018. Author, editor and reviewer genders were not available directly, so were inferred from first names using gender-mapping methods as described in the methodology.Female percentages were calculated as the percentage of the population with known gender, so that people with unknown gender were omitted from the percentage calculation. In this study we are primarily focused on the difference between male and female genders which may be more apparent when comparing names that are more clearly associated with a particular gender. Inclusion of more gender ambiguous names that could not be assigned a gender reliably would introduce other considerations. For example, we consider the geographical implications of this scope definition further in Section B3. However, we highlight that the approach gave good agreement between baseline female percentages calculated from different sources, regardless of how the gender was obtained, geography and sample size (see Section A3 for further background to this decision).For the GLM models, this meant that for any model we filtered out any data with an unknown gender in the outcome or variables being tested in that model.Much of this study is broken down into “original submissions” – this terminology is used to clarify potential ambiguity regarding multiple revisions being submitted for each article. An “original submission” counts all of the multiple revisions of an article with a particular manuscript ID only once. Some sections of this paper consider breakdowns per original submissions, some consider breakdowns per review of each revision of those original submissions, and some refer to the final outcome of each original submission which is the outcome of the last revision within the time period that the data was gathered.(A)A baseline female percentage for chemistry researchers is a necessary starting point for comparison throughout the publishing process. The UNESCO Institute for Statistics (UIS) reported the percentage of women in all science research (not just Chemistry) as 28.8%.(A1)‡This publication contains data provided by the Higher Education Statistics Agency (HESA), based on the HESA Student and Staff record from 2015/16. Copyright: Higher Education Statistics Agency Limited. Neither the Higher Education Statistics Agency Limited nor HESA Services Limited can accept responsibility for any inferences or conclusions derived by third parties from data or other information supplied by HESA Services. for students and staff for the academic year 2015/16. Staff were restricted to UK chemistry staff who perform research. The HESA student dataset was included since PhD Students are also chemistry researchers and contribute to the authorship of publications. See footnote §Staff numbers are obtained from HESA staff dataset by summing the full-time equivalent (FTE) numbers filtered by: “Session population marker” = “Contract counted within session population”; “Cost Centre” = “(113) Chemistry”; “AcademicEmploymentFunction” = “Academic contract that is both teaching and research” or “Academic contract that is research only”; “SOC marker ((311) Science, engineering and production technicians/Other)” = “Other”; “Contract levels” = “A0 to C2 Senior management” or “D and E Head of Schools/Senior Function head” or “F1 Professor” or “I0 Senior/principal lecturer, Reader, Principal Research fellow” or “J0 Lecturer, Senior Lecturer, Senior Research Fellow” or “K0 Lecturer, Research fellow, Senior research assistant, Teaching fellow” or “L0 Research assistant, Teaching assistant”. Chemistry postgraduate students from the HESA student data set were included by summing the FTEs of the HESA student record with the following filters applied: “StudentPopulationMarker” = “The record is counted within the standard HE registration population”; “StudyLevel” = “Doctorate”; “Subject2DigitJACS” = “(F1) Chemistry”; “Session population marker” = “The instance is counted within the HE session population”. for details of the populations that were included and not included in order to consider only research staff and doctorate students who might publish academic articles.The first approach to finding an appropriate baseline was to look at data provided by HESAAccording to these interrogations, there are 9255 UK chemistry researchers (staff and PhD students) of which 33.6% are female. Note that according to HESA rounding strategy, this percentage has been calculated from numbers that were rounded to the nearest 5. While it is possible for the gender recorded by HESA to have the values “male”, “female” or “other”, the numbers with “other” gender round to zero under this rounding strategy.Within this headline gender distribution, there are differences by seniority of job, as can be seen below.professorial level, the sample size reduces considerably which means that trends are no longer significant.A steep drop-off of women with rising “seniority” is in line with the RSC breaking the Barriers reportThe HESA data suggested that the percentage of chemists who are female is 33.6%, and the number of UK research chemists who are female is 3110.(A2)¶RSC Membership data was filtered to only include members with membership levels: “Affiliate”, “Affiliate Undergraduate”, “Associate Member”, “Fellow”, “Honorary Fellow”, “Member” and contacts with a job type categorised as “T01 Research” or “T25 Academic” or “T36 Postgraduate (excl. part-time)” and whose Company Type is “54 University”. This data was extracted on 28/6/2018. for data extraction details to consider only chemistry researchers by restricting by membership level and job type categories. Gender was inferred from members' first names, as described in the methodology.Another data source available to us as the Royal Society of Chemistry is the details of our membership as the UK's professional body for chemical scientists. See footnote We found that there were 10 023 RSC members who met these criteria of whom the gender of 8197 could be deduced, of whom 31.6% were female.To get a better picture of the gender distribution in chemistry research, this overall female percentage has been broken down into that at different levels of RSC membership included. The results have been plotted in Again, we see a decrease in the overall numbers as the levels increase in seniority, ascending the plot.RSC membership data suggested that the percentage of UK research chemists who are female is 31.6%, and the number of chemists who are female is 2590.(A3)The final method of estimating the baseline female percentage of chemistry researchers was to look at the female percentage of all authors of our data set of all submissions to RSC journals for the last 3 years. All authors were considered – not just corresponding or first authors, and were de-duplicated by name. Our best approximation of uniqueness of authors, in the absence of ORCID or other unambiguous author identifier, was established by deduplication of combined first name, middle name and last name, although there were some instances with an unfeasibly frequent number of submissions within this time period (as will be discussed later). Based on all authors of RSC submissions during this time-period there were 637 499 chemistry researchers of whom the gender of 310 377 could be deduced, of whom 35.8% are female. This number is in broad agreement with the proportion of all published Chemistry authors in an extensive multidisciplinary gender analysis of publications in PubMed and arXiv databases which gives a proportion of 34.7–35.4%.There is good consistency between the female percentages of all three potential baseline sources  despite differences in their sample sizes, geographies and methods of obtaining them. We have chosen to use the value based on all RSC authors, which sets the baseline of female percentage of chemistry researchers at 35.8%, since this is most relevant to the populations and methods being interrogated further in this report. The consistency in the baselines was also considered to validate our methods for estimating gender from first names, as the proportions from HESA where gender was directly known matched those of the chemistry researchers where gender was not directly known but inferred from first name.We therefore have a baseline for the number of female chemists of 35.8%. However, note that in some cases we will use different baselines specific to corresponding authors, first authors and reviewers when breaking down fluctuations within these groups.(B)This section describes investigation of possible gender imbalances apparent during the submission process of articles to the Royal Society of Chemistry.(B1)In the previous section, we considered the female percentage of all authors regardless of role, but is the female percentage of the subset of these who are corresponding authors, or first authors significantly different from the general baseline percentage of female chemists? Again having de-duplicated by name, we see that there are 121 785 unique corresponding authors of whom the gender of 64 396 could be deduced from their first name, of which 29.2% are female. There are 213 281 unique first authors of whom the gender of 103 246 could be deduced from their first name, of which 36.9% are female.The female percentage of corresponding authors is significantly lower than the baseline of female percentage of chemistry researchers. The female percentage of corresponding authors is closest to the female percentage of HESA chemistry researchers at the level “Lecturer, Senior Lecturer, Senior Research fellow” in Section A1. This is in line with the general convention that corresponding authors are largely heads of research groups.The female percentage of first authors is significantly higher than the baseline female percentage of chemistry researchers.The female percentage of first authors is closest to the female percentage of HESA chemistry researchers at the levels “Doctorate students” and “Research assistant, teaching assistant” in Section A1. This is in line with the general convention that first authors are largely the researchers who conduct the research and primarily write it up.de-duplicated female authors of submissions as baseline figures in in the rest of this paper, but rather female percentages of authors of original submissions without deduplication. Because of this, we will use the percentages of original submissions from female corresponding authors and first authors: 23.9% and 33.4% respectively. These differ from the percentages of unique authors above due to skew caused by some authors having submitted many articles, as will be discussed in the next section.However, we will not consider and compare female percentages of It is possible to identify the cases where the corresponding author is the same person as the first author (by matching their names). There are 234 317 original submissions from authors whose genders could be assigned and where this is the case, of which 26.5% are female. This lies between the two percentages for first and corresponding authors. The typical case where the corresponding author is the same as the first author might be that of early-career researchers who are establishing their own independent research. They are more senior than typical first authors are since they can address the correspondence regarding the publication themselves, but are not as senior as typical corresponding authors who are research group leaders rather than those who conduct the research themselves.(B2)In the previous section, there was a difference between the female percentage of authors and the percentage of submissions by female authors. To investigate the difference between these further we look at trends in the gender of each author with the number of original submissions from them over the three-year period for which we have data.n = 18 704) is significantly lower than for male corresponding authors  . Likewise, the mean number of submissions for female first authors  is significantly lower than those for male first authors  .Summarising these figures , the mean number of submissions for female corresponding authors Geographic effects are important to consider. While we do not have country data for all authors, we do have the correspondence address for the corresponding author at the time of publication. The corresponding authors come from a total of 157 different countries but for clarity, we show only the distribution from the top 20 countries in terms of submissions in The country where most of the corresponding authors who submit to the RSC are from is China. However, the majority of these authors do not have first names whose gender can be deduced from their first names and similarly, India, South Korea, Taiwan, Singapore and Turkey have very high proportions of corresponding authors with unknown genders. This is because our gender-assignment code uses Westernised name data sets and is not as successful with non-Westernised names. This issue would not easily be solved by simply using a more geographically diverse reference name-gender data set for comparison since, for example, it is common for Chinese, Indian, South Korean, Taiwanese and Singaporean names to be non-gender-specific and there are additional ambiguities when Asian names are converted into Latin alphabets for matching.In our methodology, we stated that we would omit people whose gender was unknown from percentage calculations and analyses. We can see from these figures that their inclusion would complicate the results and their interpretation-comparing traits of those with unknown gender alongside male and female would not simply compare gender differences between these sample sets, but also introduce geographical differences. We should however be aware that, as we can see from To explore whether a potential alternative method might increase the inclusion rate of non-Westernised author genders we have performed an additional comparison of our gender-inference method (which we will refer to as the “ONS method”) with that of another method, “gender-guesser”. Using this program, we calculated the genders of the corresponding authors, and compared them with those calculated by the ONS method. The percentage of genders of corresponding author names that matched those from the ONS method were 82.7%, which is good agreement. The distribution of these corresponding author genders by continent in We will explore geographical imbalances further in subsequent studies but the scope of this study focuses on gender disparities, and these will be more apparent by comparison of submissions from authors with names which are more readily associated with a particular gender.(B4)We now consider various traits of co-authorship of submissions: number of authors; author position; and relationship between first author gender and corresponding author gender.In n = 74 306) is significantly greater than that for male corresponding authors  .The most common number of authors for articles is five and it is apparent that there is a steady decline of female percentage of corresponding author with decreasing number of authors for articles with five or less authors. This is most apparent for single-authored papers for which there are significantly less female authors than expected from the baseline at 19.6%. The mean number of authors for submissions from female corresponding authors  were considered for publications to RSC journals from 2016 to 2018 and genders were assigned by the same mapping methods as in this study. Submissions were divided into sets defined by number of authors, and then for authors at each position in the author list the percentage of female authors ascertained, and we used a binomial significance test for comparison against the overall background female proportion. These percentages have been plotted in p-values of their binomial significance tests.In a previous investigation for internal use at the Royal Society of Chemistry we investigated some of these effects, Low female percentages are shown in purple and indicate that males are more likely to appear towards the end of the author list – traditionally the places held by the heads of research groups. Female enrichment is indicated by turquoise and is more likely to appear at the start of the author list . Other observations with this data set are that:p-value = 0.004).• Female corresponding author papers involve more institutions .• Female corresponding author papers involve more authors (p = 7.30 × 10–75 and p = 9.61 × 10–200 respectively) from the baseline of the average for corresponding authors of 23.9%. We can see a tendency for female corresponding authors to publish with female first authors.We have separately investigated the percentage of female corresponding and first authors, and will now investigate how the female percentage of corresponding authors differs with first author gender. Cases where the first author and corresponding author are the same person have been removed since these will skew results towards same-sex authorship and not truly reflect co-authorship trends. The full set of figures for the breakdown is given in Table B4b of the ESI,We observe the “gender homophily” (higher than expected occurrence of men co-authoring with men and women co-authoring with women) that has been noted previously in the life sciences.15(B5)In There is no obvious trend, based on quarter, of the percentage of female corresponding authors or first authors since 2013. It should, however, be noted that this is a short time span to monitor changes over, especially in comparison with the other similar gender studies mentioned in the introduction, the majority of which showed tendencies towards gender parity over time.9(B6)Within the general field of chemical sciences, there are sub-disciplines, so in Food and more biological subjects show higher female percentages, and Organic, Inorganic, Physical and Energy show lower female percentages. Although our exact methods differ from those reported by the IOP in their similar analysis,In general, we see similar trends for the female percentage of corresponding authors and first authors in the different chemistry sub-disciplines – for example, Energy & Environmental Science (30.06) and Chemical Society Reviews (40.182) were omitted to give a more consistent range of impact factors across the different journals over which the models are fitted.We have seen how author gender differs within chemistry sub-disciplines, and can now consider the effect of a second variable – impact factor – on the corresponding author gender within each chemistry sub-discipline by applying a GLM model. Comparisons involving impact factors across all sub-disciplines should be avoided, since there are large differences between the typical number of citations for different fields, which is why we have modelled and presented results separately for each sub-discipline. Impact factors are given with other journal information in Table ESI_1 of the ESIFood and Miscellaneous sub-disciplines. The mean impact factor of journals of female corresponding author submissions  is significantly lower than that of male corresponding authors  .In (C)After submission, the next stage in the publishing process involves an editor being assigned to each submitted article to conduct an initial assessment of its suitability for the journal and publication. If it is not suitable, the editor can reject it without peer review, or transfer it to another journal for consideration, or progress it through to peer review. We will investigate gender disparities in this stage of the publishing process in this section.(C1)We obtained the names of all the handling editors of each submission, de-duplicated them and assigned genders where possible. The genders of 691 of the 936 unique editors could be deduced, and of these, 40.4% were female. This is significantly higher than the baseline of 35.8% for chemistry researchers. Some of these editors are members of RSC staff and some of them are external Associated Editors (AE) depending on the editorial model of the journal . This is not surprising since RSC in-house editors are not academic researchers, although many of them were previously graduates from the chemical sciences, either with undergraduate or postgraduate degrees. Indeed when considering the “leaky pipeline”, the RSC is an example of one of the alternative employment destinations where many female researchers go to having left academia. Editors of submissions to journals with a hybrid model, or other mixtures of internal and external editors, have female percentages somewhere between these two extremes, as might be expected.(C2)p = 6.79 × 10–28 and p = 6.15 × 10–8 respectively) from the baseline of the average for corresponding authors of 23.9%  = 197.52, p = 7.26 × 10–45).When a paper is submitted to the RSC, the editor who is handling it will assess its suitability for the journal, and publication as a whole. The percentage of original submissions from female corresponding authors which are rejected before peer review is 25.6% compared to 23.2% which progress to peer review and both differ significantly (p = 0.0631 and p = 1.00 respectively) from the baseline of the average for first authors of 33.4%  = 30.78, p = 2.89 × 10–8). It is thus apparent that female authors have a slightly, but significantly lower success rate for initial rejection without peer review which is more apparent for corresponding authors than first authors.For first authors the female percentages of submissions which are rejected before peer review are 34.2% compared to 33.1% which progress to peer review and neither differ significantly  in The single-authored submissions show a much higher proportion of rejection at this initial stage of the publication process, which indicates that they are not a good proxy for quality to use as a control. Nevertheless, they are an interesting subset to compare, and a higher proportion of submissions from female single authors are rejected without peer review than male single authors. These proportions are not different from what might be expected for female and male corresponding authors publishing with other  authors.(C3)We can see the effects of editor gender on whether submissions from female and male corresponding authors are rejected before, or progress to peer review, using binomial GLM methods again in We can see from via a binomial GLM model The next stage of the publishing pipeline is review. Here we will investigate gender issues when choosing reviewers.(D1)Firstly, we will consider the overall gender distribution of all of the reviewers of all submissions to the RSC during the 3 years under investigation. There were 118 808 unique (de-duplicated by name) reviewers of which the gender of 68 015 could be assigned, and 24.5% were female. This value is significantly and considerably lower than the analogous female percentages of corresponding and first author of submissions in Section B1  and editors in Section C1  and considerably lower than the baseline for chemistry researchers of 35.8%. This might partly be because reviewers tend to be selected from established researchers who are more senior in their career – we note that the female percentage of reviewers is between the female percentages of HESA chemistry staff at the levels “Senior/principal lecturer, Reader, Principal Research fellow” and “Lecturer, Senior lecturer, Senior Research Fellow” in Section A1.If we consider the percentage of reviews performed by female reviewers (no longer de-duplicated by name) it is even less, at 20.8%. This difference is because the average number of reviews by female reviewers over this time period was 5.69 which is significantly less than the value for male reviewers of 7.05. So not only are there less female reviewers, but each of them perform fewer reviews than their male counterparts do.Firstly, we will consider trends in reviewer invitations. We explored if there are less women reviewers because less women are invited or because they do not accept reviewer requests as often. During the three years investigated, there were a total of 1 162 024 invitations to reviewers, and of these, the gender of 619 607 could be deduced, 21.1% of which were female. This is not significantly different from the baseline percentage of reviews performed by female reviewers (20.8%), which indicates that the low female percentage of reviews performed reflects the low percentage of invitations to female reviewers.p = 5.00 × 10–10, p = 1.15 × 10–20 and p = 1.85 × 10–28 respectively) from the baseline of the average for female reviewer invitations of 17.5%. A significantly lower percentage of female reviewers fail to respond to their reviewer invitations than male reviewers . Out of those that respond, there is no significant difference between the female percentages who accept or decline their invitations.The full set of figures for the breakdown is given in Table D1 of the ESI,We can therefore see that the low female percentage of reviews performed by female reviewers is predominantly due to them being invited less than male reviewers. When the Institute of Physics investigated this issues they found that male reviewers were invited to review more than female reviewers, and that there was “no significant difference in the propensity for men or women to accept review invitations”.7(D2)p = 1.54 × 10–61 and p = 7.26 × 10–52 respectively) from the baseline of the average for reviewers of 17.5%.We will now investigate how the percentage of reviews by female reviewers differs with corresponding author gender. The full set of figures for the breakdown is given in Table D2a of the ESI,There are significantly more reviews from female reviewers for submissions from female corresponding authors. This may be because female corresponding authors are more likely to suggest female reviewers for their papers, or because editors are more likely to select female reviewers for these papers or because female reviewers are more likely to agree to review papers from female corresponding authors. We do not have the data to test the first possible contributory factor but we can investigate the second two.A binomial GLM model of the outcome proportion of invitations to female reviewers changing with corresponding author gender and reviewer response is shown in invitations that are to female reviewers, rather than the proportion of reviews, as in the previous section. However, the same trend is apparent with more invitations going to female reviewers for submissions from female corresponding authors. The biggest difference in female proportion of reviewers with corresponding author gender is observed for reviewers who accept their invitations rather than those who decline or fail to respond. It can be seen that female reviewers accept significantly more invitations for submissions from female corresponding authors and less for submissions from male corresponding authors. From the ANOVA chi square test p-value the additional consideration of reviewer response is significant, and so the increased proportion of submissions from female corresponding authors having a female reviewer is a combination of editors inviting them more, and the female reviewers being more likely to accept these papers.The outcome in A previous study of publications in Frontiers journals found substantial gender homophily – with editors of both genders showing substantial same-gender preference when appointing reviewers.The variable EditorGender has a significant effect on reviewer gender – there is a higher female proportion of reviewers for reviews with female handling editors than male editors. Interactions between corresponding author gender and editor gender are also significant – there is a higher proportion of female reviewers for female corresponding authors for submissions with male editors than female editors.(D3)In There was a slight increase in the female percentage of reviewers through 2014 but there have been no significant changes in the percentage of female reviewers since then.There is no set number of reviewers required for a submission. If multiple versions of an article are submitted then the number of reviewers of each version are included separately.We have shown the total numbers plot and not just the percentage gender breakdown to show that most submissions have 2 reviewers, but 3 and 1 are also common. The percentage breakdown of these figures shows no significant difference in the percentage of female reviewers with the number of reviewers for the article revision taking into consideration the small sample sizes and large confidence intervals where there are more than 4 reviewers.Likewise, there are no set number of revisions for a submission. When we look at the female percentage of reviewers for each total number of revisions of submissions, as in There is a progression to higher percentages of women reviewers for submissions that have been revised many times. This ceases to be significant for more than 5 revisions and the small sample size of submissions which have more than this number of reviews should be noted.(D4)In Food has the highest female percentage of any chemistry sub-discipline, the female percentage of reviewers is 4.1% lower than that of corresponding authors. In contrast, Inorganic reviews have a female percentage of reviewers 3.1% higher than that of corresponding authors. In all, 11 of the categories have a female percentage of reviewers lower than the female percentage of corresponding authors. In particular, sub-disciplines with bigger negative differences between the female percentage of reviewers compared to corresponding authors are Environmental (4.3%), Food (4.1%), Physical (3.8%), Chemical Biology and Medicinal (3.7%).We see greater differences between the female percentages of reviewers and those of corresponding authors than the differences in Section B6 between corresponding authors and first authors. Although (E)accept/reject recommendation is binomial, this misses out on some important subtleties which are recorded in the reviewers' minor recommendations which has 4 main possible values: accept; minor revisions; major revisions, reject. The first three values are grouped together to an “accept” major recommendation. The overall percentages of reviews with each of these possible outcomes in this data set were: 20.1% accept; 28.2% for minor revision; 21.6% for major revision; 30.1% reject. From the set of reviews considered there were some additional recommendations which were recorded but with very low occurrence: recommend after revision (12 times); recommended after revision after revision (1 time); and revisions required (1214 times). When considered in the context of 904 050 reviews these outcomes are small in number, and so these recommendations have been omitted for clarity of analysis results. Nevertheless, this still leaves 4 possible outcome values to investigate, which means that it is necessary to move from a binomial GLM analysis  to a multinomial GLM analysis (see the methods section for more details). We show plots of all reviews (only limited by reviewer and corresponding author genders which are unknown) and contrast these with plots which only show first revision reviews with a control applied to show whether all reviewers were agreed on the same decision or not.We have investigated the gender characteristics of reviewers and will now investigate the effect of reviewer and author gender on reviewer recommendation. The primary outcome for this section is reviewer recommendation, and although the headline major (E1)reviewer recommendation with corresponding author gender.While the difference between the extreme outcomes of “accept” and “reject” is not so marked between male and female corresponding authors, the difference is more apparent for the grey areas in the middle – “major revision” and “minor revision”. It is apparent that the two more positive outcomes – “accept” and “minor revision” are less common for female corresponding authors, and the two more negative outcomes – “major revisions” and “reject” are more common for them.(E2)We will now investigate the effect of reviewer gender rather than corresponding author gender on the reviewer recommendations by multinomial GLM model in The strongest difference between male and female reviewers apparent in these plots is that females are less likely to reject papers than males. It is also apparent is that female reviewers are more likely to recommend major revisions than reject a paper whereas the reverse is true for male reviewers. Female reviewers are slightly (but significantly) more likely to accept papers outright than male reviewers.(E3)We will now consider the relationship between the interactions of these two variables of reviewer and author gender and first-round reviewer recommendation using a multinomial GLM. The effects are shown in The lower plots in The column with the biggest difference between the female reviewers on the top row and the male reviewers on the bottom row is that for the “reject” recommendations. The difference between female and male reviewers reflects the observation in the discussion for Section E2 that female reviewers are less likely to reject papers than male reviewers are. The additional interaction between the variables shows that while male reviewers are slightly more likely to reject papers from female corresponding authors, female reviewers do not follow this pattern.The observation in the discussion for Section E2 that female corresponding authors are less likely to have submissions accepted by reviewers than male authors is not the case when the reviewers are female, and likewise for minor revisions. Indeed, there is no significant difference between the proportions for male or female corresponding authors in all of the plots on the top line for female reviewers – suggesting that the recommendations of female reviewers differ less with corresponding author gender than those of male reviewers.(F)In Section D3 we saw that most submissions have more than one reviewer for each revision (2 or 3 were most common). We have analysed the individual reviewer recommendations and although each review is a large influence on the final outcome of the submission, the editor must evaluate and consider all reviews when coming to a final decision about the outcome of the submission. Here we will consider gender characteristics of the final outcome of the article.(F1)rejected, 22.9% accepted, 23.9% undecided and 22.8% revise  are rejected (including those that are rejected without peer review), some are accepted , some are undecided  and some have a status of “revise” . Most of the latter two cases are for submissions that had not reached their final revision before the end cut-off date of the data interrogated which is why their numbers are low. The percentage of original submissions from female corresponding authors for each these outcomes are 24.9% p = 1.25 × 10–14) below that of all submissions. Conversely, the percentage of original submissions from female corresponding authors that are ultimately rejected is very slightly, but significantly (p = 3.21 × 10–16) higher than that of all submissions (23.9%). The small sample sizes for undecided and submission for revision mean that any difference from the baseline is not significant (p = 1.00 × 10 for both). When considering submissions from first authors rather than corresponding authors, there is no significant difference between any of these outcomes and the baseline.The percentage of original submissions from female corresponding authors that are ultimately accepted, at 22.9%, is very slightly, but significantly  = 169.94, p = 7.64 × 10–39).Expressing the outcome a different way, the success rate for acceptance of all submissions for female corresponding authors is 47.38% and for male corresponding authors it is 50.1%  = 18.97, p = 1.32 × 10–5).For female first authors, the success rate is 48.0% and male first authors is 48.8% (Chisq test of independence of success frequency with gender is significant with (F2)We have investigated the reviewer recommendations and their gender characterisations previously in Section E and saw in particular that submissions from female corresponding authors were more likely to receive more negative review decisions and less likely to receive positive review decisions . We have also seen in Section F1 that this translates through to a slightly lower percentage of submissions from female corresponding authors being ultimately accepted, and a higher proportion being ultimately rejected. We will now consider the editor decision that links them, and in particular how likely it is to agree with the separate reviewer recommendations. For each headline accept/reject reviewer recommendation (where minor and major recommendations are included in the headline “accept” recommendation) we have evaluated a new variable “status and recommendation agree” with values dependent on the reviewer recommendation and final status of the revision. If the reviewer major recommendation of reject or accept matches the final status of revision, “status and recommendation agree” takes the value “Agree”. The final status “revise” is defined as agreeing with reviewer major recommendation “accept”. Other combinations are mapped onto a “Disagree” value for “status and recommendation agree”.χ2  = 20.59, p = 5.70 × 10–6). There is a small but significant difference between the level of agreement for female and male reviewers – editors are slightly more likely to decide on final statuses that agree with the recommendations of female reviewers than male reviewers.We use this dependent variable that is generated for each reviewer recommendation to investigate whether it differs with reviewer gender. The full set of figures for the breakdown is given in Table F2a of the ESI,The effect of an additional variable of corresponding author gender were again modelled using a logistic GLM – the effects are shown in There is no significant relationship between the “status and recommendation agree” variable and the corresponding author gender, and no significant interactions between corresponding author gender with this outcome.In contrast, including the interactions of an additional variable of editor gender rather than corresponding author gender in the binomial GLM model shown in p-value of the modelling of the relationship between the outcome variable of “status and recommendation agree” and the interaction of editor gender and reviewer gender shows that the relationship is significant. Female editors agree with female reviewers significantly more than male reviewers. For male editors there is no significant difference between the proportions of reviews when they agree with male reviewers compared to female reviewers.The (F3)In Section B6 we showed how the gender of corresponding authors of original submissions vary with chemistry sub-discipline, and here we investigate whether the subsections of each of these which is accepted for publication differs significantly in For all chemistry sub-disciplines, the female percentage of corresponding authors of accepted submissions is less than that of original submissions . This is not the case for female first authors where for 6 of the 13 high level subjects, the female percentage of accepted submissions is higher than that of original submissions which indicates that first authors don't experience the same level of gender imbalance.Catalysis is the sub-discipline with the greatest decrease in female percentage of corresponding authors of accepted submissions versus all original submissions with a difference of 1.1%, but Organic, and Food are slightly lower at 0.7% and Miscellaneous, and Analytical at 0.6%. All three are sub-disciplines that had a much smaller percentage of female reviewers than corresponding authors did in Section D4. In contrast, there is no difference between the female percentage of corresponding authors for submissions and acceptances for Chemical Biology and Medicinal and only a small difference of 0.2% for Biological, Nanoscience and Environmental, but it is worth noting that these are subjects with considerably fewer female reviewers than corresponding authors in Section D4.Similarly, we can revisit our analysis in Section B6, in which we investigated how the gender of authors varied across impact factor within the different sub-disciplines. Now we can consider just the subset of these submissions that were accepted. The effects of the resulting GLM model is shown in We see the same trends of female authorship for published articles as for submitted articles – the review process does not disrupt this, and there is still a drop off in the percentage of female corresponding and first authors of journals with a higher impact factor for all chemistry sub-disciplines.This is in line with previous studies which also found that a negative correlation between the Impact Factor of journals (standardised by discipline) by the proportion of women authors(F4)versus corresponding author gender, and the analogous figure for first authors in Fig. F4b of the ESI.In n = 35 206) is significantly higher than the equivalent for male corresponding authors  .n = 43 194) is significantly greater than for male corresponding authors  .We also looked at the time from initial submission to final editor decision for accepted submissions, and the mean number of days for female corresponding authors Article publication is not the end of the story. Community interest and uptake is important if the article is to further the careers of the researchers who wrote it. While it is not the only, or necessarily the best way, the number of citations of a published article has an impact on the future career of the researcher. As such, here we investigate the effect of gender on citation behaviour.Analyses in all parts of this Section G are based on 141 073 citations from RSC articles to RSC articles (no other cited or citing articles from other publishers are considered) from August 2011 until September 2018.Here we focus on corresponding authors rather than first authors since the trends are the same for both but the differences larger for corresponding authors.The baseline we use for comparison in this section is the female percentage of corresponding authors of cited articles shown above, 18.4%.(G1)versus those of citing and cited articles for citations between RSC articles.In The percentage of RSC articles that are authored by female corresponding authors and cite other RSC articles is lower than the average of all RSC articles that are accepted for publication (as described in Section F1) by female corresponding authors, and likewise for first authors.n = 11 132) is significantly less than that of male-corresponding-authored articles  .It is apparent that the female percentage of citing articles' corresponding and first authors is less than that for published articles respectively, indicating that female authors cite less than male authors. Indeed, the mean number of citations from female-corresponding-authored articles  being significantly less than that for male-authored RSC articles  . This is in contrast to Elsevier's analysis of citations in its publicationsIt is also evident from this data set that overall publications from female corresponding and first authors are cited less than those from male authors. This is corroborated by the mean number of RSC citations to female-authored RSC articles  = 174.17, p = 9.08 × 10–40). Similarly, for female first authors the success rate is 5.56% and for male corresponding authors it is 6.57%  = 98.29, p = 3.61 × 10–23). These success rates are low because citations build up over time and these publications are relatively recent, but a gender disparity is evident even on these timescales.We have also calculated the “success rate” of published articles which were cited by cross-referencing the articles which were found to have been published between 2014 to 2018 (from Section F) with the cited articles from this data set (by matching DOIs) so as to flag the “successes” as those which have been cited at least once by another RSC article. As such, the success rate for female corresponding authors is 5.25% and for male corresponding authors it is 6.79%  shows higher male authorship. For articles with citations greater than 10 there is no clear trend and small sample sizes are common particularly for the articles with large numbers of citations.(G2)Here we investigate whether citation success varies with whether the submission was unanimously accepted in its first revision . p-value. For both, the proportion of articles published by female corresponding authors have lower citation success proportions than those by male corresponding authors, and this difference is also significant. However, while both variables are significant, the interaction between them is not significant, which indicates that female corresponding authors are cited less than their male counterparts in both sets of articles.The lower citation success rate of articles which were not unanimously accepted (left-hand plot) compared to those that were (right-hand plot) is evident from the ANOVA (G3)We now investigate how citations to female authors changes over time (according to the date of the cited article) in There is a slight increase of the percentage of articles which cite articles from female corresponding authors over the time period since 2012 . However, for no year is the female percentage significantly different from the baseline of the average for citations.(G4)We investigated whether there are any significant differences between self-citation behaviour between articles in RSC journals according to gender by looking at all unique (by first name and last name) authors of all citing manuscripts in the RSC citation data set and counted the number of times that they cited a manuscript of which they were an author (by matching first name and last name). If multiple authors are self-cited in the same citing-article-cited-article pair each self-citation for each author is counted. In n = 15 175) is significantly lower than that for male authors  . The overall percentage of authors who self-cited was 44.0%.Authors with no self-citations show a higher female percentage than those with one or more self-citations, and there is a slight, but significant, trend of decreasing female percentage with increasing self-citation count. The mean number of self-citations for female authors other female corresponding authors more or less than male corresponding authors (and vice versa). The full set of figures for the breakdown is given in Table G5 of the ESI,χ2  = 19.2, p = 1.16 × 10–5). We can see that the percentage of female corresponding authors cited by other female corresponding authors is higher than that for male corresponding authors. This effect is small but significant.We now investigate whether female corresponding authors are more likely to cite other female corresponding authors. We have filtered out direct self-citations of the same cited and citing corresponding author so that results will show whether female corresponding authors cite (G6)Each cited article has been categorised into relevant chemistry sub-disciplines as described in the methodology. The female percentage of cited authors of citations in each sub-discipline is shown in Miscellaneous (22.9% difference), Food (20.6% difference), Biological (19.1% difference), Chemical Biology and Medicinal (18.5% difference), Environmental (17.2% difference).The distribution by chemistry sub-discipline is in general consistent with trends shown previously – sub-disciplines with higher female percentages of corresponding authors of published articles are those with higher percentages of citations of those. Categories in which female under-citing might be occurring (with the biggest differences in percentages for cited and published corresponding authors) are In For the majority of Chemistry sub-disciplines, there is a decrease in the percentage of citations to articles with female corresponding authors with increasing impact factor. The exceptions are Energy, which shows the opposite trend, and Environmental and Nanoscience show no marked increase or decrease with female corresponding author citation percentage with impact factor.(H)We have seen small but significant gender-based differences during the publication process over the limited time range under investigation. We now turn out attention to consider the combined effect over time of these differences on H-index,We have taken this list, and expanded the first initial to a name  and run these first names through our gender mapping script to assign gender of each. Because of the small sample size, and small number of females that emerged, thorough manual checking and adjustment was performed on the genders that were obtained. The total numbers for each H-index band are shown in Only 19 female authors appear in the list of 547 chemistry researchers – a percentage of 3.5%, which is significantly different from the baseline female percentage of chemistry researchers overall 35.8%.n = 16) and for male chemists was 69.3 , the difference between which is not significant . However, the main salient point from considering the ages of these chemists is that, as might be expected, they correspond to an age and career stage where females are underrepresented (due to the “leaky pipeline”) even before the number of publications and citations are considered. Reflection of the gender balance of a previous generation of chemists may also be exacerbated by these H-index values and their rankings being from 2011 rather than more current.We should, however, note that H-index has been criticised as an unfair measure of publication success. H-Index values vary greatly with chemistry sub-discipline, favouring sub-disciplines that are more prolific in terms of publications and citations at the expense of those that produce fewer publications. Also, by its nature, H-index ranking favours those researchers who are further on in their career and in years. To investigate this we have also obtained the years of birth of these chemists where available from Wikipedia and internet searching and found that the mean age of female chemists when the original analysis was conducted in 2011 was 66.1  might address this to some extent.We have conducted a thorough analysis of data available to us as the Royal Society of Chemistry, and as publishers of the chemical sciences, in order to identify gender imbalances.e.g. cliques); and differences in review styles (e.g. sentiment).We are releasing code, tools and data with this paper for others to use in their analysis. The work described in this paper is only the start in terms of studying gender bias in the chemical sciences. We are planning to extend this work to ascertain reasons for the imbalances we see. We plan to explore further the imbalances we observed by investigating: improving the gender assignment methods to get a more inclusive picture of the differences; patterns of behaviour . This means that the analysis considers 53% of corresponding authors, 48% of first authors, 57% of reviewers, but 74% of editors, and as discussed in Section B3, it was apparent that those not included are predominantly of Asian origin, even when an alternative gender-assignment method and name-gender mapping data set were used. For parts of this analysis which focus on characteristics of authors, reviewers and editors this is an unfortunate but somewhat unavoidable limitation in the scope of this study that we should highlight. When considering potential conscious and unconscious biases towards authors and reviewers when it comes to rejection without peer review, reviewer decision, editor decision and citations, these biases will be stronger towards or against those researchers whose names are more readily associated with a particular gender. This paper therefore focuses on the effects of more inter-Westernised gender biases, rather than those that might exist in non-Westernised cultures or between Westernised and non-Westernised cultures, the latter of which would additionally be complicated by geographical biases.In Section A we looked at 3 different data sets to establish a baseline of 35.8% of chemistry researchers that are female. As demonstrated in In Section B, we saw that female authors submit fewer articles (Section B2), are less likely to author a paper on their own (Section B4) and are more likely to submit to journals with a lower impact factor within a particular chemistry sub-discipline (Section B6) than their male counterparts. Female first authors are more likely to co-author with female corresponding authors than male corresponding authors and the converse is true (Section B4).e.g. revisions 3, 4, and 5 (Section D3). Female reviewers are more likely to review submissions from female corresponding authors (D2) and when they do, they are more likely to accept or recommend minor revisions for these female corresponding authors than their male counterparts (Section E3). However, though, in general, reviewers are more likely to recommend rejection or major revisions rather than acceptance or minor revisions for submissions from female corresponding authors than male ones (Section E1). Female reviewers are more likely to recommend major revisions rather than rejection for submissions that they review (Section E2).Articles authored by female corresponding and first authors are more likely to be rejected without review than those from male corresponding authors (Section C2). While there is a higher percentage of female editors than the baseline for Chemistry researchers (Section C1) , female reviewers are under-represented, reflecting the female percentage of invitations rather than a tendency to accept those invitations less or decline them more (Section D1). Female reviewers are more likely to review papers that have been under revision many times These reviewer recommendations add up to slightly (but significantly) fewer submissions from corresponding authors being accepted for publication than those of their male counterparts (Section F1) although this is not significant for female first authors compared to male first authors (Section F1). Editors are slightly but significantly more likely to choose a final status of a revision which agrees with female reviewers than male reviewers (Section F2) and this difference increases more in cases where the editor is female (Section F2). There is a slightly but significantly higher female percentage of corresponding authors of submissions with increasing number of revisions (Section F4). The mean time from submission to final decision for accepted submissions from female corresponding authors is significantly greater than that from male corresponding authors (Section F4). The proportion of female corresponding and first authors of accepted articles for higher impact journals within a sub-discipline are lower than that for lower impact journals (Section F6), following the similar trend for submissions by impact factor and gender (Section B6), and with important implications to potentially limit the impact of the research and careers of these female authors.Published articles from female corresponding and first authors (to a lesser extent) receive fewer citations than those from their male counterparts (Section G1). Female corresponding authors cite less articles than male corresponding authors (Section G1). Publications with female corresponding authors are less likely to be highly cited than those of their male counterparts (Section G1). Articles that were unanimously accepted by reviewers were proportionally cited less for female corresponding authors than those by male corresponding authors (G2). Male authors self-cite more than their female counterparts (Section G4). Female corresponding authors are more likely to cite other female corresponding authors and the converse is true (Section G5). There is a decrease of the percentage of female corresponding authors of citations with impact factor for the majority  of Chemistry sub-disciplines (G6).In summary, we do not see one dominant factor disadvantaging female researchers in the publishing process, but a series of small but significant results. We did, however, observe some evidence of gender homophily  – with female researchers working together to counteract these imbalances.Food, Environmental, Biological and Chemical Biology and Medicinal – (Sections B6 and F3) are also those which are most under-represented by female reviewers (Section D4) and under-cited for female corresponding authors (Section G6). The sub-disciplines with lower female authorship are Organic, Catalysis, Inorganic and Energy (Section B6 and F3), but Inorganic is the only sub-discipline which has a higher percentage of reviewers than that of submitting corresponding authors (Section D4).There are some differences within Chemistry sub-disciplines, but those which are strongest in female corresponding and first authorship of submissions and publications – There is no significant change in the female proportion of corresponding or first authors of submissions (Section B5) or reviewers (Section D3) over the 3 year period investigated, or the number of citations to publications by female corresponding authors over time from 2012 till 2018 (Section G3).In Section H, a marked under-representation of female researchers was evident in the living chemists with the highest H-index scores.e.g. impact of journal or number of authors. Cause 2  is somewhat debateable and controversial, but research quality could be affected by factors such as lower research grant funding being awarded to female principal investigatorsWe have provided evidence that there are compounding disparities between male chemists and their female counterparts through the publication process and have characterised these as far as possible. Several differences identified in this paper  could be interpreted as being due to lower productivity at fixed evaluation points . An underlying question is whether this gender difference is due to (1) gender bias, (2) a difference in the research quality according to author gender or (3) other systematic differences in the submission features of male and female co-authors that might affect publication success In an accompanying reporthttps://bitbucket.org/rscapplications/genderdiversity/src/master/.R code examples and partial datasets for this project are available for download at: Chemical Science Associate Editor, Alan Aspuru-Guzik. In the interests of full transparency, the identities of the reviewers are published alongside the reviewer reports and authors' response accompanying this article as ESI.Aileen Day, Peter Corbett and John Boyle are employees of the Royal Society of Chemistry (RSC), however they were not involved in, or had access to information on, the peer review selection, evaluation and decision process for this article. No RSC staff members were involved in the editorial decision taken on this manuscript, which was taken by Peer review detailsClick here for additional data file.Supplementary informationClick here for additional data file.


For those who were born and raised before the digital age, it is evident that nowadaysinformation spreads itself extremely fast and effectively. In this universe of availabledata, generally within reach of the palm of our hands, it is sometimes difficult toseparate false from truth. Communication today can be false, distorted and biased andstill be dispersed in great speed, without frontiers or limits, gaining the samestrength as what should be trusted.In this scenario, scientific journals have gained force as a north, since their mainobjective is to disseminate information from the scientific world that has been analyzedand certified through peer reviewing. In addition, publications guarantee authorship andorigin of the work, as well as serve as public archives for future searches.The editorial process of scientific journals dates back to 1665 when the first issue ofthe Philosophical Transactions of the Royal Society was published and included ninearticles, a dedication, a list of books and other correspondences.On the other hand, the academic pressure for scientific publication seems to blur thereal purpose of the publication itself. This is understandable and legitimate regardingthe publication of articles resulting from research, which are generally financed bydevelopment agencies. In addition, the number and quality of publications by aresearcher or professor classifies him within the academic environment. This demand ledto a great proliferation of journals of the same area, which ended up also beingclassified through the most diverse indexes, such as the impact factor.Therefore, in this universe of multiple options, the editorial team of a journal isconcerned with its ranking, in order to be chosen by authors with submissions ofrelevant articles. The DPJO was founded 25 years ago as a local journal, published inPortuguese, by a private publisher. Since then it has been published uninterruptedlyevery two months and has always tried to improve to maintain its focus: thedissemination of information within the area of Orthodontics.Along these 25 years, editors and reviewers have worked voluntarily to transform a localjournal into a periodical with international reach. The DPJO is currently an open-accessjournal, published in English, and indexed in the main scientific databases. In theSCImago Journal Ranking the DPJO is the tenth journal in the area of orthodontics andthe third open access journal in this area in the world.This growth of the DPJO has attracted a significant number of submissions from all overthe world in the past 5 years. Due to the limited space for publication and the demandfor approved articles, the final publication time is longer than desired. In order toexpedite our publications, the DPJO decided to make a series of changes. Starting in thefirst edition of 2021, the journal will no longer exist in print and will be publishedin a continuous flow model. That is, the articles will be made available in thedatabases before the completion of a number. This more modern model provides greaterflexibility in the authors’ publication and immediate access to the journal’s readers.The sections by guest authors will also be reduced in number, allowing the publicationof more original articles, and editorials will be published only in special situations.In addition, to celebrate its 25 years of existence, the DPJO will start 2021 with a newformat, completely digital and adapted for tablets and smartphones.This current year was surprised by instant changes and we participated in theestablishment of an even more digital and possibly faster world. In this way, the DPJO’snew formatting and editing process are adapted to these new times, but respecting thegood old practices. With these changes, the journal reaffirms its commitment to science,to authors and readers, hoping for an even higher ranking and relevance for the journal.However, we continue with our main objective: to guarantee qualified information, in ademocratic way, to those who have a commitment to orthodontics based on scientificevidence.Long live the DPJO.


Substance use disorders (SUDs) cause heavy economic burden and seriously challenges public security. Nearly 35 million people are receiving substance abuse treatment, and 585,000 people in the world died from overdose in 2017 (The United Nations Office on Drugs and Crime, These understandings were addressed in a recent study published in the journal of Proceedings of the National Academy of Sciences of the United States of America by Hu et al. . The resDrug addiction is characterized by disruption in finely balanced brain networks. Over the two decades, the animal models (Shippenberg and Koob, In conclusion, this research has suggested that the imbalance of brain circuits plays an important role in maladaptive behavior in drug dependents (Everitt and Robbins, H-BZ, HZ, YZ, and DZ conceived the idea and wrote the manuscript together. All authors listed have made a substantial, direct and intellectual contribution to the work, and approved it for publication.The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.


In this Editorial, the Editor‐in‐Chief Professor Miguel A. De la Rosa introduces the new members of the Editorial Board and discusses the effects of COVID‐19 on the journal. FEBS Open Bio. These appointments bring new expertise to the journal and also ensure that the journal is editorially represented in China, South Korea, and the United States. Biosketches of our new editors are included below. I am also pleased to announce the appointment of Janesh Kumar  and Chongde Sun  to our Editorial Advisory Board. I welcome all of our new editors to the journal.This month, I am delighted to announce the appointment of In Hye Lee, Josep Rizo, and Guang‐Biao Zhou to the editorial board of openbio@febs.org if you require an extension for any reason.I would also like to take this opportunity to sincerely thank all of our editors and reviewers for their hard work and support at this very challenging time. The ongoing COVID‐19 crisis has caused massive disruption globally, creating challenges for us all. Increasing numbers of researchers are facing the disruption of laboratory closures and having to arrange online teaching while simultaneously dealing with the effects of the pandemic on their daily lives. Some of our editors, reviewers, and authors are also physicians battling the pandemic on the frontlines. As such, delays during this difficult period are unavoidable, and I would like to thank everyone for their kind understanding and patience. We are happy to give extensions to all authors who need it, even after deadlines have passed. Please contact the editorial office at Dr. In Hye Lee completed her doctoral training as well as undergraduate studies at Ewha Womans University (EWU), Seoul, South Korea, where she studied cell signaling pathways to regulate cell proliferation, cell cycle, and tumorigenesis. After receiving her Ph.D. from EWU, she moved to the National Heart Lung Blood Institute (NHLBI), NIH, Bethesda, USA, for postdoctoral training in the laboratory of Dr. Toren Finkel, where she focused on the connection between autophagy and sirtuins. After being appointed as a federal government employer of the National Institute of Health (NIH), USA, she continued to study the physiological roles of autophagy. Since returning to EWU, Dr. Lee’s laboratory has focused on exploring molecular pathways to connect metabolism to aging.13C NMR spectroscopy, and later on, the development of polar protecting groups for peptide synthesis. In 1989, he started postdoctoral research in the laboratory of Lila Gierasch at UT Southwestern, working on conformational studies of a variety of peptides by NMR spectroscopy and molecular dynamics. In the early 1990s, he shifted his interest to protein NMR and protein folding. He established his independent research group in 1995 at UT Southwestern. The main focus of his research is the study of the mechanisms of neurotransmitter release and intracellular membrane fusion using structural biology, a variety of biophysical techniques and reconstitution approaches. He is currently Professor in the Departments of Biophysics, Biochemistry, and Pharmacology.Professor Josep Rizo (Jose Rizo‐Rey) was born in Barcelona, Spain, in 1959. He received a B.Sc. degree in Organic Chemistry in 1981 from the University of Barcelona. During these college studies, he became very interested in quantum field theory and statistical mechanics, which led him to obtain a second B.Sc. degree, this time in theoretical physics, from the same university in 1988. During the 1982–1988 period, he also obtained MSc and PhD degrees in organic chemistry from the University of Barcelona, working in the laboratories of Ernest Giralt and Enrique Pedroso. He first worked on pioneering methodology to analyze peptides attached to solid supports by gel‐phase Frontiers of Medicine. His suggestions to mitigate air pollution and protect people from air pollution‐induced health hazards were accepted by the government, resulting in an improvement of air quality in north China.Dr. Guang‐Biao Zhou is Professor and Deputy Director of State Key Laboratory of Molecular Oncology, National Cancer Center/Chinese Academy of Medical Sciences Cancer Institute and Hospital. He was Distinguished Professor of the Chinese Academy of Sciences and is Director of the Department of Pathology and Pathophysiology of School of Medicine, University of Chinese Academy of Sciences. He investigates tobacco smoke‐ and air pollution‐induced lung carcinogenesis, including dissection of abnormalities in genomes, noncoding RNAs, immune escape, and inflammatory factors, using systematic approaches. He also investigates the mechanisms of action of traditional Chinese medicine in treating cancer. He has published more than 100 peer‐reviewed journal articles, and obtained the National Natural Science Funds for Distinguished Young Scholars from the National Natural Science Foundation of China. He is the Executive Deputy Editor‐in‐Chief of the journal


Women's Health Reports. Women's Health Reports is a companion journal to Journal of Women's Health and allows for an expansion of the literature into new territories that our flagship journal cannot accommodate due to space constraints imposed by the print format model. Women's Health Reports will provide a home for clinical papers, translational research, and health promotion and wellness articles covering a broad range of topics. Clinical case reports, basic research papers, and other articles that are regional in scope or of interest to specialized groups of readers will be a better fit for Women's Health Reports.We are pleased to announce the launch of a new online open access journal, Readers will appreciate this new publication being open access, meaning that no subscription is required to access and read the content. For authors, publishing under a creative commons license allows for them to maintain ownership of their copyright. This model allows for a win-win on both sides and fosters a spirit of openness and collaboration. This spirit is important for driving research in our field forward as we aim to support advances in healthcare for women around the world.


R. Soc. Open Sci.3, 180526 (Published 30 May 2018) (doi:10.1098/rsos.180526)https://royalsocietypublishing.org/doi/10.1098/rsos.180526, Royal Society Open Science received correspondence expressing concern about the technical accuracy of this paper. Consequently, the journal conducted an independent post hoc assessment of the paper, resulting in this Expression of Concern.Following peer review and publication of 1.As can be seen in the open review history of the paper, there was a divergence of opinion from the initial reviewers and the author mounted a response in a scholarly and comprehensive manner. This presents a challenge to editors: do the concerns outweigh potential positives? Does publishing a controversial approach add value to the literature through stimulating open debate? As for most academic journals, while reviewers make recommendations, editors make the final decision on what is acceptable for publication. Editors possess the ultimate veto. On balance, in this case, the decision was made to publish to encourage debate, which is central to scientific research.2.While recognizing that a controversial paper may eventually be shown to contain flaws, it may be argued that all science is a work in progress. We move forward not in a linear process, but often in fractures of existing paradigms—the history of science is littered with examples of this. The editors felt that research presented in this paper may stimulate further debate and experimentation in this space. If a journal only ever published papers that reinforced existing mainstream knowledge, then science would be the poorer.3.Royal Society Open Science has a remit to publish research that is appropriate for publication and which may be difficult to publish in more traditional journals. At the time of assessment and publication, the paper passed that test in the view of the editors. Furthermore, the journal's open peer review model allows readers to explore the review history for themselves.4.Independent assessors that subsequently performed post-publication peer review on this manuscript have agreed to make their commentary available publicly and these are now online together with the author's responses. These comments can be read alongside this Expression of Concern. As the reader may note, there is no consensus on this work, which is why the journal has opted not to retract.5.As with any human endeavour, the decision to publish a paper is not an exact science and editors balance a number of factors to decide what is appropriate. We remind readers that the journal permits and actively encourages replication studies. If readers with an interest in this field would like to submit either a replication or rebuttal of the author's work, we would welcome it.6.It should be noted that correspondents critiquing the decision to publish this paper have been offered the opportunity to publish a rebuttal but, to date, have thus far declined to do so. We would once again encourage them and any others who may be interested to make open contributions in order to openly articulate and formalize the technical issues.A short explanation for the decision-making process to help readers understand why the editors opted to accept the paper is as follows: