Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study
Peter D. Ahiawodzi, Richard A. Kerber, Kira C. Taylor, Frank D. Groves, Elizabeth O'Brien, Joachim H. Ix, Jorge R. Kizer, Luc Djoussé, Russell P. Tracy, Anne B. Newman, David S. Siscovick, John Robbins, Kenneth Mukamal
Context: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease. Objective: The objective of this study is to investigate the association between sleep-disordered breathing (SDB)–a source of oxidative stress–and CML. Materials and methods: About 1002 participants in the Cardiovascular Health Study (CHS) were studied. Results: Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03–2.58, p = 0.04). The association was not significant among men. Discussion: SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study. Conclusion: Accumulation of CML may be an adverse health consequence of SDB.
Apnea–Hypopnea Index
Carboxymethyl-lysine
advanced glycation end-product
sleep-disordered breathing
Dive into the research topics of 'Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study'. Together they form a unique fingerprint.
N(6)-carboxymethyllysine Medicine & Life Sciences 100%
Sleep Apnea Syndromes Medicine & Life Sciences 71%
Oxidative Stress Chemical Compounds 65%
Elderly Medicine & Life Sciences 44%
Cardiovascular Diseases Medicine & Life Sciences 9%
Ahiawodzi, P. D., Kerber, R. A., Taylor, K. C., Groves, F. D., O'Brien, E., Ix, J. H., Kizer, J. R., Djoussé, L., Tracy, R. P., Newman, A. B., Siscovick, D. S., Robbins, J., & Mukamal, K. (2017). Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study. Biomarkers, 22(3-4), 361-366. https://doi.org/10.1080/1354750X.2016.1276966
Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study. / Ahiawodzi, Peter D.; Kerber, Richard A.; Taylor, Kira C. et al.
In: Biomarkers, Vol. 22, No. 3-4, 19.05.2017, p. 361-366.
Ahiawodzi, PD, Kerber, RA, Taylor, KC, Groves, FD, O'Brien, E, Ix, JH, Kizer, JR, Djoussé, L, Tracy, RP, Newman, AB, Siscovick, DS, Robbins, J & Mukamal, K 2017, 'Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study', Biomarkers, vol. 22, no. 3-4, pp. 361-366. https://doi.org/10.1080/1354750X.2016.1276966
Ahiawodzi PD, Kerber RA, Taylor KC, Groves FD, O'Brien E, Ix JH et al. Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study. Biomarkers. 2017 May 19;22(3-4):361-366. doi: 10.1080/1354750X.2016.1276966
Ahiawodzi, Peter D. ; Kerber, Richard A. ; Taylor, Kira C. et al. / Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study. In: Biomarkers. 2017 ; Vol. 22, No. 3-4. pp. 361-366.
@article{04760f958ea44b7bb6d68726a51ef2be,
title = "Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study",
abstract = "Context: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease. Objective: The objective of this study is to investigate the association between sleep-disordered breathing (SDB)–a source of oxidative stress–and CML. Materials and methods: About 1002 participants in the Cardiovascular Health Study (CHS) were studied. Results: Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03–2.58, p = 0.04). The association was not significant among men. Discussion: SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study. Conclusion: Accumulation of CML may be an adverse health consequence of SDB.",
keywords = "Apnea–Hypopnea Index, Carboxymethyl-lysine, advanced glycation end-product, oxidative stress, sleep-disordered breathing",
author = "Ahiawodzi, {Peter D.} and Kerber, {Richard A.} and Taylor, {Kira C.} and Groves, {Frank D.} and Elizabeth O'Brien and Ix, {Joachim H.} and Kizer, {Jorge R.} and Luc Djouss{\'e} and Tracy, {Russell P.} and Newman, {Anne B.} and Siscovick, {David S.} and John Robbins and Kenneth Mukamal",
note = "Funding Information: This research was supported by R01HL094555, as well as by Contracts HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083 and N01HC85086, and Grant U01HL080295 from the National Heart, Lung, and Blood Institute (NHLBI), with additional contribution from the National Institute of Neurological Disorders and Stroke (NINDS). Additional support was provided by R01AG023629 from the National Institute on Aging (NIA). A full list of principal CHS investigators and institutions can be found at http://www.chs-nhlbi.org/PI. Publisher Copyright: {\textcopyright} 2017 Informa UK Limited, trading as Taylor & Francis Group.",
journal = "Biomarkers",
T1 - Sleep-disordered breathing is associated with higher carboxymethyllysine level in elderly women but not elderly men in the cardiovascular health study
AU - Ahiawodzi, Peter D.
AU - Kerber, Richard A.
AU - Taylor, Kira C.
AU - Groves, Frank D.
AU - O'Brien, Elizabeth
AU - Ix, Joachim H.
AU - Kizer, Jorge R.
AU - Djoussé, Luc
AU - Newman, Anne B.
AU - Siscovick, David S.
AU - Robbins, John
AU - Mukamal, Kenneth
N1 - Funding Information: This research was supported by R01HL094555, as well as by Contracts HHSN268201200036C, HHSN268200800007C, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083 and N01HC85086, and Grant U01HL080295 from the National Heart, Lung, and Blood Institute (NHLBI), with additional contribution from the National Institute of Neurological Disorders and Stroke (NINDS). Additional support was provided by R01AG023629 from the National Institute on Aging (NIA). A full list of principal CHS investigators and institutions can be found at http://www.chs-nhlbi.org/PI. Publisher Copyright: © 2017 Informa UK Limited, trading as Taylor & Francis Group.
N2 - Context: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease. Objective: The objective of this study is to investigate the association between sleep-disordered breathing (SDB)–a source of oxidative stress–and CML. Materials and methods: About 1002 participants in the Cardiovascular Health Study (CHS) were studied. Results: Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03–2.58, p = 0.04). The association was not significant among men. Discussion: SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study. Conclusion: Accumulation of CML may be an adverse health consequence of SDB.
AB - Context: Carboxymethyl-lysine (CML) results from oxidative stress and has been linked to cardiovascular disease. Objective: The objective of this study is to investigate the association between sleep-disordered breathing (SDB)–a source of oxidative stress–and CML. Materials and methods: About 1002 participants in the Cardiovascular Health Study (CHS) were studied. Results: Women with SDB had significantly higher CML concentration compared with those without SDB (OR = 1.63, 95%CI = 1.03–2.58, p = 0.04). The association was not significant among men. Discussion: SDB was associated with CML concentration among elderly women but not men in the Cardiovascular Health Study. Conclusion: Accumulation of CML may be an adverse health consequence of SDB.
KW - Apnea–Hypopnea Index
KW - Carboxymethyl-lysine
KW - advanced glycation end-product
KW - oxidative stress
KW - sleep-disordered breathing
JO - Biomarkers
JF - Biomarkers