Randomised trial of intravenous infusion of ephedrine or mephentermine for management of hypotension during spinal anaesthesia for Caesarean section.
Anaesthesia. 2005 Jan; 60(1):28-34.A
This study compared the effects of intravenous infusions of ephedrine and mephentermine for maintenance of maternal arterial pressure and neonatal outcome in pregnant women receiving subarachnoid block for lower segment Caesarean section. Sixty patients who developed hypotension following subarachnoid block for Caesarean section were randomly divided into two groups of 30 each to receive an intravenous infusion of ephedrine or mephentermine. Hypotension was defined as a decrease in systolic blood pressure of > or = 20% from the baseline value or an absolute value of <100 mmHg, whichever was higher. The vasopressor infusion was titrated to maintain systolic blood pressure between 'hypotension' and baseline values. Baseline haemodynamic parameters, haemodynamic changes subsequent to the start of vasopressor infusion, duration of hypotension and amount of vasopressor required were statistically similar for both groups. Neonatal APGAR scores and acid-base profiles were also comparable. To conclude, mephentermine can be used as safely and effectively as ephedrine for the management of hypotension during spinal anaesthesia in patients undergoing elective Caesarean section.
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Kansal A
Department of Anaesthesiology and Critical care, University College of Medical Sciences, Guru Teg Bahadur Hospital, Delhi 110096, India.
Mohta M
Sethi AK
Tyagi A
Kumar P
Adrenergic AgentsAdultAnesthesia, ObstetricalAnesthesia, SpinalApgar ScoreCesarean SectionDouble-Blind MethodEphedrineFemaleHemodynamicsHumansHypotensionInfusions, IntravenousMephenterminePregnancyPregnancy OutcomeVasoconstrictor Agents
Kansal, A, et al. "Randomised Trial of Intravenous Infusion of Ephedrine or Mephentermine for Management of Hypotension During Spinal Anaesthesia for Caesarean Section." Anaesthesia, vol. 60, no. 1, 2005, pp. 28-34.
Kansal A, Mohta M, Sethi AK, et al. Randomised trial of intravenous infusion of ephedrine or mephentermine for management of hypotension during spinal anaesthesia for Caesarean section. Anaesthesia. 2005;60(1):28-34.
Kansal, A., Mohta, M., Sethi, A. K., Tyagi, A., & Kumar, P. (2005). Randomised trial of intravenous infusion of ephedrine or mephentermine for management of hypotension during spinal anaesthesia for Caesarean section. Anaesthesia, 60(1), 28-34.
Kansal A, et al. Randomised Trial of Intravenous Infusion of Ephedrine or Mephentermine for Management of Hypotension During Spinal Anaesthesia for Caesarean Section. Anaesthesia. 2005;60(1):28-34. PubMed PMID: 15601269.
TY - JOUR T1 - Randomised trial of intravenous infusion of ephedrine or mephentermine for management of hypotension during spinal anaesthesia for Caesarean section. AU - Kansal,A, AU - Mohta,M, AU - Sethi,A K, AU - Tyagi,A, AU - Kumar,P, PY - 2004/12/17/pubmed PY - 2005/1/28/medline PY - 2004/12/17/entrez SP - 28 EP - 34 JF - Anaesthesia JO - Anaesthesia VL - 60 IS - 1 N2 - This study compared the effects of intravenous infusions of ephedrine and mephentermine for maintenance of maternal arterial pressure and neonatal outcome in pregnant women receiving subarachnoid block for lower segment Caesarean section. Sixty patients who developed hypotension following subarachnoid block for Caesarean section were randomly divided into two groups of 30 each to receive an intravenous infusion of ephedrine or mephentermine. Hypotension was defined as a decrease in systolic blood pressure of > or = 20% from the baseline value or an absolute value of <100 mmHg, whichever was higher. The vasopressor infusion was titrated to maintain systolic blood pressure between 'hypotension' and baseline values. Baseline haemodynamic parameters, haemodynamic changes subsequent to the start of vasopressor infusion, duration of hypotension and amount of vasopressor required were statistically similar for both groups. Neonatal APGAR scores and acid-base profiles were also comparable. To conclude, mephentermine can be used as safely and effectively as ephedrine for the management of hypotension during spinal anaesthesia in patients undergoing elective Caesarean section. SN - 0003-2409 UR - https://www.unboundmedicine.com/medline/citation/15601269/Randomised_trial_of_intravenous_infusion_of_ephedrine_or_mephentermine_for_management_of_hypotension_during_spinal_anaesthesia_for_Caesarean_section_ L2 - https://doi.org/10.1111/j.1365-2044.2004.03994.x DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓10]
Adrenergic Agents
Anesthesia, Obstetrical
Anesthesia, Spinal
Apgar Score
Hemodynamics
Infusions, Intravenous
Mephentermine
Vasoconstrictor Agents
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