Case Reports |1 March 1966
Cryofibrinogenemia, Multiple Dysproteinemias, and Hypervolemia in a Patient with a Primary Hepatoma
WILLIAM BELL, M.D.; RAYMOND BAHR, M.D.; THOMAS A. WALDMANN, M.D.; PAUL P. CARBONE, M.D.
In 1955, Korst and Kratochvil (1) reported a patient with a pulmonary neoplasm and thrombophlebitis migrans in whom a cold-preciptable fibrinogen (cryofibrinogen) was detected. Subsequently, cryofibrinogenemia has been described as a primary (idiopathic) and more frequently as a secondary disorder (2). Primary (2) and secondary (3) cryofibrinogenemia may be associated with cold intolerance, Raynaud's phenomenon, and acrocyanosis. In the secondary disorder, thrombo-embolic occlusive phenomena and hemorrhagic diatheses are common.
The present report concerns a patient with a primary hepatoma and markedly elevated plasma levels of fibrinogen and cryofibrinogen. These findings were not associated with any thrombotic or bleeding disorders or
BELL W, BAHR R, WALDMANN TA, et al. Cryofibrinogenemia, Multiple Dysproteinemias, and Hypervolemia in a Patient with a Primary Hepatoma. Ann Intern Med. 1966;64:658–664. doi: https://doi.org/10.7326/0003-4819-64-3-658
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