Cognitive Impairment Associated with Cancer: A Brief Review.
Published on Feb 1, 2018in Innovations in clinical neuroscience
J. Cara Pendergrass6
Estimated H-index: 6
, Steven D. Targum26
, John Harrison44
This brief review explores the areas of cognitive impairment that have been observed in cancer patients and survivors, the cognitive assessment tools used, and the management of the observed cognitive changes. Cognitive changes and impairment observed in patients with cancer and those in remission can be related to the direct effects of cancer itself, nonspecific factors or comorbid conditions that are independent of the actual disease, and/or the treatments or combination of treatments administered. Attention, memory, and executive functioning are the most frequently identified cognitive domains impacted by cancer. However, the prevalence and extent of impairment remains largely unknown due to marked differences in methodology, definitions of cognitive impairment, and the assessment measures used. Assessment of cognitive functioning is an important and necessary part of a comprehensive oncological care plan. Research is needed to establish a better understanding of cognitive changes and impairments associated with cancer so that optimal patient outcomes can be achieved.
References (104)Citations (64)
Candidate mechanisms for chemotherapy-induced cognitive changes.
200760.72Nature Reviews Cancer
2 Authors (Tim A. Ahles, Andrew J. Saykin)
Cancer-related Cognitive Impairment
201932.98Annals of Oncology
1 Author (Janette Vardy)
Cognitive impairment in older adults with cancer.
20212.30Current Opinion in Supportive and Palliative Care
3 Authors (Mari Lloyd-Williams, ..., Karen Harrison Dening)
References104
Cognitive function and its relationship to other psychosocial factors in lymphoma survivors.
Mar 1, 2017·Supportive Care in Cancer3.60
#1Dorothy Krolak (Ottawa Hospital Research Institute)H-Index: 1
#2Barbara Collins (Ottawa Hospital Research Institute)H-Index: 16
Last. Richard van der Jagt (Ottawa Hospital Research Institute)H-Index: 17
Purpose The purpose of this study was to estimate the prevalence of cognitive disturbance in lymphoma survivors and to explore relationships between cognitive function and other psychosocial factors.
Feasibility of baseline neurocognitive assessment using Cogstate during the first month of therapy for childhood leukemia.
Feb 1, 2017·Supportive Care in Cancer3.60
#1Stephen A. Sands (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 22
#2Brian T. Harel (Yale University)H-Index: 13
Last. Peter D. Cole (Albert Einstein College of Medicine)H-Index: 22
Purpose Neurocognitive impairment is frequently observed among acute lymphoblastic leukemia (ALL) survivors within the domains of intelligence, attention, processing speed, working memory, learning, and memory. However, few have investigated treatment-induced changes in neurocognitive function during the first months of treatment. Additionally, dysfunction during treatment may be preceded by changes in biomarkers measured within cerebrospinal fluid (CSF). Identification of acute declines in neur... more
Recommended cognitive outcomes in preclinical Alzheimer's disease: Consensus statement from the European Prevention of Alzheimer's Dementia project
Feb 1, 2017·Alzheimers & Dementia21.57
#1Karen Ritchie (University of Montpellier)H-Index: 57
#2Michael T. Ropacki (Janssen Pharmaceutica)H-Index: 8
Last. Craig W. Ritchie (Edin.: University of Edinburgh)H-Index: 47
Abstract The Horizon 2020/IMI European Prevention of Alzheimer's Dementia (EPAD) project will undertake large-scale proof-of-concept trials in predementia Alzheimer's disease (AD). Within EPAD, the monitoring of cognitive trajectories in the preclinical period will constitute a central outcome measure; however, there are currently no clear guidelines as to how this should be achieved as most measures have been developed for the period around dementia diagnosis. The EPAD Scientific Advisory Group... more
Convergent and criterion validity of the CogState computerized brief battery cognitive assessment in women with and without breast cancer
Jan 12, 2017·Clinical Neuropsychologist3.54
#1Sunita K. Patel (City of Hope National Medical Center)H-Index: 20
#2Adrienne M. Meier (City of Hope National Medical Center)H-Index: 5
Last. Nicole Delgado (City of Hope National Medical Center)H-Index: 2
Abstract Objective: Computerized tests have increasingly garnered interest for assessing cognitive functioning due to their potential logistical and financial advantages over traditional 'pencil and-paper' neuropsychological tests. However, psychometric information is necessary to guide decisions about their clinical and research utility with varied populations. We explored the convergent construct validity and criterion validity of the CogState computerized tests in breast cancer survivors, a g... more
Selection of cognitive tests for trials of therapeutic agents.
Jun 1, 2016·The Lancet Psychiatry26.48
#1John HarrisonH-Index: 44
#2Raymond W. Lam (UBC: University of British Columbia)H-Index: 84
Last. Roger S. McIntyre (Toronto Western Hospital)H-Index: 4
Which Cognitive Domains are Improved by Treatment with Vortioxetine
May 26, 2016·The International Journal of Neuropsychopharmacology5.18
#1John Harrison (VUmc: VU University Medical Center)H-Index: 44
#2Søren Lophaven (Lundbeck)H-Index: 6
Last. Christina Kurre Olsen (Lundbeck)H-Index: 16
Background: These post-hoc analyses evaluated vortioxetine efficacy on cognitive dysfunction in depression. Data were from a double-blind, randomized, fixed-dose, placebo-controlled, 8-week depression study in adults aged 18-65 years (n=602) with DSM-IV-defined major depressive disorder (MDD). Subjects were randomized (1:1:1) to vortioxetine 10mg/day, 20mg/day or placebo. Methods: Cognitive function was assessed at baseline, Week 1 (10mg/day only) and Week 8 using DSST number of correct symbols,... more
Measuring the mind: detecting cognitive deficits and measuring cognitive change in patients with depression
#2Roger S. McIntyreH-Index: 99
Last. Danielle S. ChaH-Index: 26
A study of donepezil in female breast cancer survivors with self-reported cognitive dysfunction 1 to 5 years following adjuvant chemotherapy
Feb 1, 2016·Journal of Cancer Survivorship4.44
#1Julia Lawrence (Wake Forest University)H-Index: 13
#2Leah Griffin (Wake Forest University)H-Index: 17
Last. Stephen R. Rapp (Wake Forest University)H-Index: 61
Purpose Some breast cancer survivors report cognitive difficulties greater than 1 year after chemotherapy. Acetylcholinesterase inhibitors (AChEI) may improve cognitive impairment. We conducted a randomized, placebo-controlled, pilot study to assess the feasibility of using the AChEI, donepezil, to improve subjective and objective measures of cognitive function in breast cancer survivors.
Cognitive effects of donepezil therapy in patients with brain tumors: a pilot study
Jan 6, 2016·Journal of Neuro-oncology4.13
#1Denise D. Correa (Cornell University)H-Index: 25
#2Maria Kryza-Lacombe (Cornell University)H-Index: 12
Last. Lisa M. DeAngelis (Cornell University)H-Index: 111
Cognitive dysfunction is prevalent among brain tumor patients treated with radiotherapy (RT) and chemotherapy. However, there are no approved pharmacological interventions for cognitive dysfunction in cancer patients. The goal of this pilot study was to examine the efficacy of donepezil, an acetylcholinesterase inhibitor used to treat Alzheimer's disease, in improving cognitive functions in brain tumor patients previously treated with RT + chemotherapy or chemotherapy alone. Fifteen patients wit... more
Donepezil for Irradiated Brain Tumor Survivors: A Phase III Randomized Placebo-Controlled Clinical Trial
May 20, 2015·Journal of Clinical Oncology44.54
#1Stephen R. RappH-Index: 61
#2L. Doug CaseH-Index: 11
Last. Edward G. ShawH-Index: 60
Purpose Neurotoxic effects of brain irradiation include cognitive impairment in 50% to 90% of patients. Prior studies have suggested that donepezil, a neurotransmitter modulator, may improve cognitive function. Patients and Methods A total of 198 adult brain tumor survivors ≥ 6 months after partial- or whole-brain irradiation were randomly assigned to receive a single daily dose (5 mg for 6 weeks, 10 mg for 18 weeks) of donepezil or placebo. A cognitive test battery assessing memory, attention, ... more
Cited By64
Improving preoperative breast reconstruction consultations: a qualitative study on the impact of personalised audio-recordings.
Nov 6, 2021·BMC Women's Health2.81
#1Josipa Petric (Flinders Medical Centre)H-Index: 1
#2Bahara Sadri (Flinders University)
Last. Nicola R. Dean (Flinders Medical Centre)H-Index: 12
BACKGROUND To investigate the value of audio-recordings in aiding patient understanding and recall of preoperative breast reconstruction information. METHODS This was a prospective cohort study. Participants were randomly allocated into either a recording group who were offered the opportunity to record their breast reconstruction explanation of surgery, or a standard information package group who received standard care. The value of having an audio-recording was assessed by semi-structured inte... more
Four decades of chemotherapy-induced cognitive dysfunction: comprehensive review of clinical, animal and in vitro studies, and insights of key initiating events.
Nov 2, 2021·Archives of Toxicology5.15
#1Ana Dias-Carvalho (University of Porto)
#2Mariana Simões Larraz Ferreira (University of Porto)H-Index: 15
Last. Vera Marisa Costa (University of Porto)H-Index: 27
Cognitive dysfunction has been one of the most reported and studied adverse effects of cancer treatment, but, for many years, it was overlooked by the medical community. Nevertheless, the medical and scientific communities have now recognized that the cognitive deficits caused by chemotherapy have a strong impact on the morbidity of cancer treated patients. In fact, chemotherapy-induced cognitive dysfunction or 'chemobrain' (also named also chemofog) is at present a well-recognized effect of che... more
Changes and Influencing Factors of Cognitive Impairment in Patients with Breast Cancer
Oct 28, 2021·Evidence-based Complementary and Alternative Medicine2.63
#1Huixia Cui
#2Xusheng Shi
Last. Wenlu Zhang
Objective. To investigate the changes in cognitive function and its influencing factors in patients with breast cancer after chemotherapy, to provide a scientific basis for further cognitive correction therapy. Methods. In this study, general information on age, marital status, and chemotherapy regimen was collected from 172 breast cancer chemotherapy patients. 172 patients with breast cancer undergoing chemotherapy were investigated by convenience sampling method, and the subjects were tested o... more
The Value of Bayesian Methods for Accurate and Efficient Neuropsychological Assessment.
Oct 19, 2021·Journal of The International Neuropsychological Society2.89
#1Hanne Huygelier (Katholieke Universiteit Leuven)H-Index: 6
#2Céline R. Gillebert (Katholieke Universiteit Leuven)H-Index: 20
Last. Pieter Moors (Katholieke Universiteit Leuven)H-Index: 14
OBJECTIVE Clinical neuropsychology has been slow in adopting novelties in psychometrics, statistics, and technology. Researchers have indicated that the stationary nature of clinical neuropsychology endangers its evidence-based character. In addition to a technological crisis, there may be a statistical crisis affecting clinical neuropsychology. That is, the frequentist null hypothesis significance testing framework remains the dominant approach in clinical practice, despite a recent surge in cr... more
Cross sectional association between cytomegalovirus seropositivity, inflammation and cognitive impairment in elderly cancer survivors.
Oct 12, 2021·Cancer Causes & Control2.51
#1Sithara Vivek (UMN: University of Minnesota)H-Index: 5
#2Heather H. Nelson (UMN: University of Minnesota)H-Index: 69
Last. Bharat Thyagarajan (UMN: University of Minnesota)H-Index: 30
PURPOSE The higher prevalence of cognitive impairment/ dementia among cancer survivors is likely multifactorial. Since both exposures to cytomegalovirus (CMV) and inflammation are common among elderly cancer survivors, we evaluated their contribution towards dementia. METHODS Data from 1387 cancer survivors and 7004 participants without cancer in the 2016 wave of the Health and Retirement Study (HRS) was used in this study. Two inflammatory biomarkers, C-reactive protein (CRP) and neutrophil-lym... more
Delineating the role of binge eating in cancer research.
Oct 1, 2021·Eating and Weight Disorders-studies on Anorexia Bulimia and Obesity4.65
#1Tyler B. Mason (SC: University of Southern California)H-Index: 19
#2Kathryn E. Smith (SC: University of Southern California)H-Index: 18
Purpose Binge eating is defined as consumption of a large amount of food accompanied by a sense of loss of control over eating. While binge eating is associated with poor physical, behavioral, and psychosocial health, it has not been studied in cancer research. Therefore, the overarching goal of this review is to delineate the role of binge eating in cancer research and to spur new research in this area. Specifically, in this review, we outlined (1) binge eating as a possible risk factor that co... more
Central Nervous System Plasticity Influences Language and Cognitive Recovery in Adult Glioma.
Sep 15, 2021·Neurosurgery4.65
#1Saritha Krishna (UCSF: University of California, San Francisco)H-Index: 8
#2Sofia Kakaizada (UCSF: University of California, San Francisco)H-Index: 5
Last. Shawn L. Hervey-Jumper (UCSF: University of California, San Francisco)H-Index: 23
Gliomas exist within the framework of complex neuronal circuitry in which network dynamics influence both tumor biology and cognition. The generalized impairment of cognition or loss of language function is a common occurrence for glioma patients. The interface between intrinsic brain tumors such as gliomas and functional cognitive networks are poorly understood. The ability to communicate effectively is critically important for receiving oncological therapies and maintaining a high quality of l... more
Longitudinal associations between cancer history and cognitive functioning among older adults
Sep 11, 2021·Archives of Gerontology and Geriatrics3.25
#1Kun Wang (UA: University of Alabama)
#2Leah P. Cheatham (UA: University of Alabama)H-Index: 6
Last. Xiayu Chen (NYU: New York University)
Abstract null null Objectives null This study aimed to examine 1) whether cancer history accelerates older adults' rates of cognitive decline over time and 2) whether chemotherapy increases older cancer patients'/ survivors' rates of cognitive decline over time. null null null Methods null This longitudinal study drew a subsample of 8,811 adults aged 65 or older from Wave 6 of the Health and Retirement Study in 2002 and followed biannually until Wave 13 in 2016. Linear mixed-effects models were ... more
Working memory training for adult glioma patients: a proof-of-concept study.
Sep 7, 2021·Journal of Neuro-oncology4.13
#1Sarah Braun (VCU: Virginia Commonwealth University)H-Index: 7
#2Farah Aslanzadeh (VCU: Virginia Commonwealth University)H-Index: 2
Last. Ashlee R. Loughan (VCU: Virginia Commonwealth University)H-Index: 5
CogMed Working Memory Training (CWMT) is a computer-based program shown to improve working memory (WM) among those with cognitive impairments. No study to date has investigated its feasibility, acceptability, and satisfaction in adult patients with glioma, despite the well-documented incidence of WM impairment in this population. Twenty patients with glioma and objective and/or perceived WM deficits enrolled in the study: 52% high-grade, 60% female, Mage = 47 (range = 21–72 years). Adverse event... more
Physical Activity Patterns and Relationships With Cognitive Function in Patients With Breast Cancer Before, During, and After Chemotherapy in a Prospective, Nationwide Study.
Aug 18, 2021·Journal of Clinical Oncology44.54
#1Elizabeth A. Salerno (WashU: Washington University in St. Louis)H-Index: 7
#2Eva Culakova (URMC: University of Rochester Medical Center)H-Index: 30
Last. Karen M. Mustian (URMC: University of Rochester Medical Center)H-Index: 58
PURPOSEPhysical activity (PA) is a promising intervention for cancer-related cognitive decline, yet research assessing its use during chemotherapy is limited. This study evaluated patterns of PA be...