Photodynamic therapy for facial squamous cell carcinoma in cats using Photofrin®
C. J. Chang, Y. L. Lai, C. J. Wong
Background: Photodynamic therapy (PDT) has been shown to be an effective treatment modality for surface-oriented neoplasms of the skin, respiratory, gastrointestinal and urogenital systems. The purpose of our study was to assess the safety and efficacy of PDT using Photofrin® in the treatment of squamous cell carcinomas of feline facial skin. Materials and Methods: Cats with naturally occurring squamous cell carcinomas of the skin were entered into the study. PDT was delivered to the tumors using an argon-pumped dye laser 48 hours after the administration of the photosensitizer porfimer sodium (Photofrin®). Following treatment, the tumors were evaluated for complete response rates and local control durations. Results: Eight tumors were staged T1a, 9 staged T1b, and 14 staged T2b. Complete response rates as well as local control durations were significantly related to stage (p < 0.0001). Complete response was achieved in 100% of the T1a tumors and 53% of the T1b tumors; the overall 1-year local control rate for all treated tumors was 62%. Clinical, hematological, and biochemical evidence of toxicity was not seen in any cat following drug administration. Conclusion: PDT with the photosensitizer Photofrin® was safe and effective in treating early stage squamous cell carcinomas of the feline skin.
Chang Gung Medical Journal
Dihematoporphyrin Ether
Photochemotherapy
Photosensitizing Agents
Urogenital System
Dye Lasers
Skin Neoplasms
Photofrin®
Photosensitizer
Chang, C. J., Lai, Y. L., & Wong, C. J. (1998). Photodynamic therapy for facial squamous cell carcinoma in cats using Photofrin®. Chang Gung Medical Journal, 21(1), 13-19.
Photodynamic therapy for facial squamous cell carcinoma in cats using Photofrin®. / Chang, C. J.; Lai, Y. L.; Wong, C. J.
In: Chang Gung Medical Journal, Vol. 21, No. 1, 01.01.1998, p. 13-19.
Chang, CJ, Lai, YL & Wong, CJ 1998, 'Photodynamic therapy for facial squamous cell carcinoma in cats using Photofrin®', Chang Gung Medical Journal, vol. 21, no. 1, pp. 13-19.
Chang CJ, Lai YL, Wong CJ. Photodynamic therapy for facial squamous cell carcinoma in cats using Photofrin®. Chang Gung Medical Journal. 1998 Jan 1;21(1):13-19.
Chang, C. J. ; Lai, Y. L. ; Wong, C. J. / Photodynamic therapy for facial squamous cell carcinoma in cats using Photofrin®. In: Chang Gung Medical Journal. 1998 ; Vol. 21, No. 1. pp. 13-19.
@article{c1ff4a6b44cf48ba91b5947989a05f3e,
title = "Photodynamic therapy for facial squamous cell carcinoma in cats using Photofrin{\circledR}",
abstract = "Background: Photodynamic therapy (PDT) has been shown to be an effective treatment modality for surface-oriented neoplasms of the skin, respiratory, gastrointestinal and urogenital systems. The purpose of our study was to assess the safety and efficacy of PDT using Photofrin{\circledR} in the treatment of squamous cell carcinomas of feline facial skin. Materials and Methods: Cats with naturally occurring squamous cell carcinomas of the skin were entered into the study. PDT was delivered to the tumors using an argon-pumped dye laser 48 hours after the administration of the photosensitizer porfimer sodium (Photofrin{\circledR}). Following treatment, the tumors were evaluated for complete response rates and local control durations. Results: Eight tumors were staged T1a, 9 staged T1b, and 14 staged T2b. Complete response rates as well as local control durations were significantly related to stage (p < 0.0001). Complete response was achieved in 100{\%} of the T1a tumors and 53{\%} of the T1b tumors; the overall 1-year local control rate for all treated tumors was 62{\%}. Clinical, hematological, and biochemical evidence of toxicity was not seen in any cat following drug administration. Conclusion: PDT with the photosensitizer Photofrin{\circledR} was safe and effective in treating early stage squamous cell carcinomas of the feline skin.",
keywords = "Photodynamic therapy, Photofrin{\circledR}, Photosensitizer, Squamous cell carcinoma",
author = "Chang, {C. J.} and Lai, {Y. L.} and Wong, {C. J.}",
journal = "Chang Gung Medical Journal",
publisher = "Chang Gung Medical Journal",
T1 - Photodynamic therapy for facial squamous cell carcinoma in cats using Photofrin®
AU - Chang, C. J.
AU - Lai, Y. L.
AU - Wong, C. J.
N2 - Background: Photodynamic therapy (PDT) has been shown to be an effective treatment modality for surface-oriented neoplasms of the skin, respiratory, gastrointestinal and urogenital systems. The purpose of our study was to assess the safety and efficacy of PDT using Photofrin® in the treatment of squamous cell carcinomas of feline facial skin. Materials and Methods: Cats with naturally occurring squamous cell carcinomas of the skin were entered into the study. PDT was delivered to the tumors using an argon-pumped dye laser 48 hours after the administration of the photosensitizer porfimer sodium (Photofrin®). Following treatment, the tumors were evaluated for complete response rates and local control durations. Results: Eight tumors were staged T1a, 9 staged T1b, and 14 staged T2b. Complete response rates as well as local control durations were significantly related to stage (p < 0.0001). Complete response was achieved in 100% of the T1a tumors and 53% of the T1b tumors; the overall 1-year local control rate for all treated tumors was 62%. Clinical, hematological, and biochemical evidence of toxicity was not seen in any cat following drug administration. Conclusion: PDT with the photosensitizer Photofrin® was safe and effective in treating early stage squamous cell carcinomas of the feline skin.
AB - Background: Photodynamic therapy (PDT) has been shown to be an effective treatment modality for surface-oriented neoplasms of the skin, respiratory, gastrointestinal and urogenital systems. The purpose of our study was to assess the safety and efficacy of PDT using Photofrin® in the treatment of squamous cell carcinomas of feline facial skin. Materials and Methods: Cats with naturally occurring squamous cell carcinomas of the skin were entered into the study. PDT was delivered to the tumors using an argon-pumped dye laser 48 hours after the administration of the photosensitizer porfimer sodium (Photofrin®). Following treatment, the tumors were evaluated for complete response rates and local control durations. Results: Eight tumors were staged T1a, 9 staged T1b, and 14 staged T2b. Complete response rates as well as local control durations were significantly related to stage (p < 0.0001). Complete response was achieved in 100% of the T1a tumors and 53% of the T1b tumors; the overall 1-year local control rate for all treated tumors was 62%. Clinical, hematological, and biochemical evidence of toxicity was not seen in any cat following drug administration. Conclusion: PDT with the photosensitizer Photofrin® was safe and effective in treating early stage squamous cell carcinomas of the feline skin.
KW - Photodynamic therapy
KW - Photofrin®
KW - Photosensitizer
KW - Squamous cell carcinoma
JO - Chang Gung Medical Journal
JF - Chang Gung Medical Journal