Cluster of differentiation 3/ CD3
What is cluster of differentiation 3 / CD3 ?
Cluster of differentiation 3 consists of five different polypeptide chains with molecular weights ranging from 16 to 28 kD. CD3 have four different invariant chains: CD3 gamma, CD3 delta, CD3 epsilon, and CD3 zeta. The CD3 antigen is expressed in early thymocytes and its appearance probably represents one of the earliest signs of commitment to the T cell lineage.
What is the role of cluster of differentiation 3 in the immune system?
In immunology, Cluster of differentiation 3 as T-cell co-receptor helps to activate the cytotoxic T-Cell. CD3 consists of a protein complex and is composed of four distinct chains. These chains associate with a molecule known as the T-cell receptor (TCR) and the ζ-chain (zeta-chain) to generate an activation signal in T lymphocytes. The TCR, ζ-chain, and CD3 molecules together constitute the TCR complex. The complex functions to transduce intracellular signals during TCR antigen recognition. CD3 epsilon is one of at least three invariant proteins that associate with the variable antigen recognition chains of the T cell receptor and function in signal transduction.
Why is it important to study cluster of differentiation 3?
Cluster of differentiation 3 has high specificity, at all stages of T-cell development, makes it a useful immunohistochemical marker for T-cells in tissue sections. The antigen remains present in almost all T-cell lymphomas and leukaemias, and can therefore be used to distinguish them from superficially similar B-cell and myeloid neoplasms.
Because cluster of differentiation 3 is required for T-cell activation, drugs (often monoclonal antibodies) that target it are being investigated as immunosuppressant therapies for type 1 diabetes and other autoimmune diseases.
Cluster of differentiation antigen 3/CD3 Reasearch Reagent Category
CD3d Proteins
CD3e Proteins
CD3G Proteins
CD3d Antibodies
CD3e Antibodies
CD3G Antibodies
CD3d Genes
CD3e Genes
CD3G Genes
CD3d other products
CD3e other products
CD3G other products
what is cluster of differentiation
cluster of differentiation nomenclature
cluster of differentiation as markers
cluster of differentiation function
cluster of differentiation classification by Immunophenotyping
• cluster of differentiation in stem cells
• cluster of differentiation in granulocyte
• cluster of differentiation in monocyte
• cluster of differentiation in T lymphocyte
• cluster of differentiation in helper T cell
• cluster of differentiation in regulatory T cell
• cluster of differentiation in cytotoxic T cell
• cluster of differentiation in B lymphocyte
• cluster of differentiation in platelet
• cluster of differentiation in NK cell
cluster of differentiation 4 / CD4
• cluster of differentiation 3γ
• cluster of differentiation 3δ
• cluster of differentiation 3ε
clusters of differentiation of the B7 family
clusters of differentiation of FC receptor