Revenue for Ripretinib by Deciphera Pharmaceuticals is expected to have a CAGR of -8.49% through 2038. How does that impact the rNPV of the drug?
Ripretinib is a Small Molecule owned by Deciphera Pharmaceuticals, and is involved in 10 clinical trials, which were completed.
Ripretinib (Qinlock, DCC-2618) blocks cKIT mutated in a region called (exon 17) and the mutant D816V form of cKIT causative of mast cell leukemia and mastocytosis. The proto-oncogene c-Kit forms an active dimer that autophosphorylates itself and activates a signaling cascade that induces cell growth. PDGF and its receptors are implicated in tumorigenesis and angiogenesis. Thus, DCC-2618 acts on a mutant cKIT and mutant platelet derived growth factor receptor (PDGFR) alpha and inhibits tumor cell proliferation and angiogenesis.
The revenue for Ripretinib is expected to reach a total of $2.8bn through 2038. This change impacts the valuation of this asset and is an important factor to understand the current value of the drug in a clinical process. View the complete picture with the Ripretinib NPV Report.
Ripretinib is originated and owned by Deciphera Pharmaceuticals. Zai Lab is the other company associated in development or marketing of Ripretinib.
Ripretinib Overview
Ripretinib (Qinlock) is a potent antineoplastic agent. It is formulated as tablets for oral route of administration. Qinlock is indicated for the treatment of adult patients with advanced gastrointestinal stromal tumor (GIST) who have received prior treatment with 3 or more kinase inhibitors, including imatinib.
Ripretinib (DCC-2618) was under development for the treatment of gastrointestinal stromal tumor (GIST), melanoma, anaplastic astrocytomas, glioblastoma multiforme, non-small cell lung cancer, glioma, germ cell tumors, penile cancer, soft tissue sarcoma, hematologic malignancy, systemic mastocytosis, solid tumor and mast cell leukemia. The drug candidate is a small molecule, administered through the oral route. It binds to mutant cKIT (including exons 14 and 17) and mutant platelet derived growth factor receptor alpha (PDGFRA). It is developed based on kinase inhibitor technology platform which provides the basis for the discovery and development of kinase switch pocket inhibitors.
Deciphera Pharmaceuticals Overview
Deciphera Pharmaceuticals is a research and development company that develops, designs, and commercializes kinase inhibiting drugs. The company provides clinical pipeline of kinase inhibitors such as tumor-targeted therapies and immuno-targeted therapies. It uses proprietary switch control inhibitor platform for discovering and developing kinase inhibitors. Deciphera Pharmaceuticals products are used in the treatment of renal and colon cancers, mastocytosis, gastrointestinal stromal tumors, crohn's disease and autoimmune nephritis, solid tumors and rheumatoid arthritis. The company's products are used in the treatment of immunological diseases and cancers. It markets its products through medical representatives. Deciphera Pharmaceuticals is headquartered in Waltham, Massachusetts, the US
The company reported revenues of (US Dollars) US$96.2 million for the fiscal year ended December 2021 (FY2021), compared to a revenue of US$42.1 million in FY2020. The operating loss of the company was US$300.1 million in FY2021, compared to an operating loss of US$271.2 million in FY2020. The net loss of the company was US$300 million in FY2021, compared to a net loss of US$266.5 million in FY2020. The company reported revenues of US$36 million for the third quarter ended September 2022, an increase of 10.7% over the previous quarter.
Quick View – Ripretinib
Innovator (NME)
Ripretinib
Sponsor Company: Deciphera Pharmaceuticals
Originator: Deciphera Pharmaceuticals
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