Siliciano, Robert F.
Johns Hopkins University, Baltimore, MD, United States
Search 135 grants from Robert Siliciano
Search grants from Johns Hopkins University
Metabolic Vulnerability of Synapses in Neurodegenerative Disease
Development of proximity-induced fluorogenic reactions for imaging biomolecular interaction through noncanonical amino acid mutagenesis in response to quadruplet codon and recoding signal
Cell Biology of Signaling across Membranes
Molecular Genetics of Usher Syndrome Type III
District of Columbia Science & Engineering Regional Center for Minorities
New optical Monte Carlo simulation tools for nuclear medicine
This is an application for renewal of the Medical Scientist Training Program at The Johns Hopkins University School of Medicine. The Program, now in its 29th year, seeks to train MD-PhD students for positions of leadership in academic medicine and medical research. During the previous funding period, applications increased steadily to a record level of 574. Interviews are extended to less than 20% of these students;applicants invited for interviews have outstanding academic records (mean GPA 3.9), excellent MCAT scores (average single test score 12.1), significant laboratory research experience, and high motivation for careers in biomedical research and clinical medicine. Approximately 10 to 12 students enter the Program each year and on average 10 students receive MSTP awards. The average length of study for the combined degrees is between 7-8 years. There are currently 92 MD/PhD students in the Program;54 have MSTP awards. Four have individual NRSA awards. Enrollment of underrepresented minorities has increased to 32%. Students generally take two years of preclinical science courses and then enroll in a graduate program for approximately four years. During this time, students take advanced courses and select from a pool of over 500 potential mentors. Mentors selected have well supported research programs ($1,500,000 average ADC) and substantial training experience (average of 15 prior trainees). Students complete thesis research, publishing an average of 6.3 peer-reviewed papers, before returning to complete the remaining required clinical clerkships and electives in medical school. The MSTP Director is a Johns Hopkins faculty member who is also an active investigator. The Director heads a 29-member MD-PhD Committee that admits applicants and formulates policies for the Program. The committee members also assist the Director in advising trainees and evaluating student progress. The Program has been highly successful in fulfilling the goals initially set forth by the NIH. Since the inception of the Johns Hopkins MSTP training grant, 232 MD/PhD students have graduated from the Program. Of these, 165 had MSTP support;163 have completed postgraduate training and have begun their careers. Of these, 88% are in medical research positions. This includes those in academic medicine (69%), those at research institutes such as the NIH (7%), and those in the pharmaceutical or biotech industries (12%).
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
3T32GM007309-35S1
National Institute of General Medical Sciences Initial Review Group (BRT)
Shapiro, Bert I
Neumann, Neil M; Perrone, Matthew C; Veldhuis, Jim H et al. (2018) Coordination of Receptor Tyrosine Kinase Signaling and Interfacial Tension Dynamics Drives Radial Intercalation and Tube Elongation. Dev Cell 45:67-82.e6
Kinkead, Heather L; Hopkins, Alexander; Lutz, Eric et al. (2018) Combining STING-based neoantigen-targeted vaccine with checkpoint modulators enhances antitumor immunity in murine pancreatic cancer. JCI Insight 3:
Cash, Ayla; Luo, Xun; Chow, Eric K H et al. (2018) HIV+ deceased donor referrals: A national survey of organ procurement organizations. Clin Transplant 32:
Hung, Alice L; Maxwell, Russell; Theodros, Debebe et al. (2018) TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM. Oncoimmunology 7:e1466769
Tang, Olive; Juraschek, Stephen P; Appel, Lawrence J (2018) Design Features of Randomized Clinical Trials of Vitamin D and Falls: A Systematic Review. Nutrients 10:
Tang, Olive; Juraschek, Stephen P; Appel, Lawrence J et al. (2018) Comparison of automated clinical and research blood pressure measurements: Implications for clinical practice and trial design. J Clin Hypertens (Greenwich) 20:1676-1682
Wang, Yuxuan; Li, Lu; Douville, Christopher et al. (2018) Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers. Sci Transl Med 10:
Peng, Xi; Emiliani, Francesco; Smallwood, Philip M et al. (2018) Affinity capture of polyribosomes followed by RNAseq (ACAPseq), a discovery platform for protein-protein interactions. Elife 7:
Garzon-Muvdi, Tomas; Theodros, Debebe; Luksik, Andrew S et al. (2018) Dendritic cell activation enhances anti-PD-1 mediated immunotherapy against glioblastoma. Oncotarget 9:20681-20697
Grover, Surbhi; Desir, Fidel; Jing, Yuezhou et al. (2018) Reduced Cancer Survival Among Adults With HIV and AIDS-Defining Illnesses Despite No Difference in Cancer Stage at Diagnosis. J Acquir Immune Defic Syndr 79:421-429
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