Enterofuril
Enterofuril is a modern intestinal antiseptic sulfanilamide with a wide spectrum of action.
It is a derivative of nitrofuran. It is widely used in acute intestinal infections, accompanied by diarrhea. The active ingredient is nifuroxazide, active against many pathogenic microorganisms.
At the same time, depending on the dosage of the drug, a different therapeutic effect can be achieved. Thus, Enterofuril in low and medium doses can have a bacteriostatic effect, and in high doses - a bactericidal effect. When using an antiseptic, it does not disturb the balance of beneficial microflora and does not cause dysbiosis.
Enterofuril is safe, well tolerated, and comes in convenient dosage forms that facilitate its use in infants.
Clinico-pharmacological group
Intestinal antiseptic. Antidiarrheal drug.
Terms of sale from pharmacies
Can be bought without a doctor's prescription.
How much does Enterofuril suspension cost in pharmacies? The average price is at 400 rubles.
Composition and release form
The manufacturer offers to purchase Enterofuril in capsules or as a suspension.
Capsules are made in dosages of 200 and 100 mg. The first - 10 pieces in a blister, the second - 8. Eight oblong tablets, yellow. They contain powder of the same color, which can be crumbly, pressed or containing pressed elements;
Suspension comes from the factory in a bottle of dark glass, with a volume of 90 ml. In the carton box attached instructions for use and measuring spoon with graduation. On the neck - opening control. The substance is thick, yellow, with a banana flavor.
Both the capsules and the suspension have a bright yellow color, which is required nifuroxazide, and not dyes. The liquid form is sold in finished form, it does not need to be diluted with water, which is very convenient. Since the drug, mainly, for children, the bottle is closed with a lid with protection against children: to open it, you need to apply force, pushing until it clicks.
Both forms of Enterofuril can be taken by adults, while a child under seven years old does not prescribe capsules because of their size. But a competent pediatrician will be able to calculate the dose of dry matter from a capsule that a small person could take if it is impossible to acquire a suspension. Please note that the drug is absorbed in liquid form more quickly, therefore, in order to relieve acute manifestations in adults, it is permissible to start therapy with this form of medicine.
Pharmacological effect
The tool has a high degree of safety, efficiency and has a minimal amount of side effects. The drug is based on nifuroxazide - a substance belonging to the number of derivatives of 5-nitrofuran. This is a broad spectrum bactericidal drug. When released into the intestine, the active substance penetrates into the bacteria and interferes with their vital activity. In low and medium concentrations, the substance has a bacteriostatic action, disrupting the synthesis of the enzyme dehydrogenase in microorganisms. Due to this, the synthesis of certain proteins is stopped, and microbes cease to multiply. In high concentrations, the substance destroys the cell membranes of bacteria, and they die. The substance also has the ability to inhibit the production of toxins by bacteria and stimulate the activity of phagocytes - special cells of the immune system that fight infection.
A positive feature of the tool is that it acts extremely selectively, attacking only harmful microorganisms, and does not affect the beneficial microflora. By this, the medicine favorably differs from many antibiotics, which arrange total terror in the intestines, destroying all bacteria, both good and bad. But the saprophytic intestinal microflora plays an important role in the digestive process. As a result, it is difficult to restore it by taking probiotic preparations.
The list of microorganisms that Enterofuril acts on is quite impressive. Among them are gram-positive and gram-negative bacteria:
Clostridia;
Klebsiella;
Enterobacteria;
Campylobacter;
Staphylococcus;
Streptococci;
Salmonella;
Shigella;
Intestinal sticks;
Cholera vibrios;
Bacteria of the genus Edwardsiella;
Citrobacter;
Yersinia enterocolitic.
Moreover, practice shows that bacteria are unable to develop resistance to the drug.
Enterofuril has several indications for use. The main one is the treatment of bacterial infections of the gastrointestinal tract associated with diarrhea. The drug may also be used in the case of chronic gastrointestinal lesions of bacterial etiology of unknown genesis. Another benefit of Enterofuril is that it almost does not penetrate the bloodstream and carries out its activities exclusively in the intestines. The drug is excreted from the body along with feces.
From this feature directly derive a few more advantages of the tool. First, the drug does not penetrate the placental barrier, and also does not pass into the mother's milk. Secondly, Enterofuril is suitable for use for children in the treatment of intestinal infections and dysbacteriosis. Only children under 1 month cannot take Enterofuril. It is undesirable to give children up to 7 years old the drug in capsulated form In this case, there is a special suspension for children.
Indications for taking the drug following:
chronic or acute diarrhea associated with pathogens that are sensitive to the spectrum of the drug;
chronic inflammatory process in the large intestine with background diarrhea;
frequent loose stools after antibiotic therapy;
infectious lesions of the gastrointestinal tract with manifestations of diarrhea;
chronic or acute intestinal disorder with unclear cause.
As one of the components of complex treatment, the drug is included in the schemes of such diseases as:
gastroenteritis: toxic, allergic, on the background of radiation therapy;
colitis, including erosive inflammation;
Crohn's disease;
enterocolitis;
intestinal pathology on the background of vascular disorders.
According to the research, I use the drug in the treatment of chronic diseases of the gastrointestinal tract with signs of dyspeptic disorders. During treatment with Enterofuril, it is important to replenish the water - electrolyte balance, as dehydration develops as a result of vomiting and frequent loose stools.
Enterofuril in the form of a suspension for oral administration:
use in patients under the age of one month of life;
use for the treatment of diarrhea caused by helminth infections;
hypersensitivity to Enterofuril or its components;
use in premature infants;
individual intolerance to Enterofuril or its components;
use more than one week in a row.
Enterofuril in capsule form with different content of active ingredient:
use in patients under the age of seven years;
Use with caution: simultaneous use of Enterofuril with any medications containing ethyl alcohol.
Appointment during pregnancy and lactation
Enterofuril can be used as prescribed by a doctor during pregnancy and breastfeeding. Since the active substance is not absorbed into the bloodstream, it cannot have a negative effect on the health of the expectant mother and child.
Nifuroxazide does not penetrate into breast milk, so the use of the drug is allowed during lactation. The dosage of the drug and the treatment regimen are selected by the attending physician on an individual basis, taking into account the severity of the infection and the patient's condition, the treatment is carried out under his control.
Dosage and method of use
As indicated in the instructions for use for dosing suspension Enterofuril used measuring spoon with a volume of 5 ml, with a graduation of 2.5 ml.
Before use, the suspension should be well shaken.
Aged children from 1 to 6 months: 2.5 ml of suspension 2-3 times / day with an interval from 8 to 12 h.
Children from 7 months to 3 years: 2.5 ml of suspension 3 times / day with an interval of 8 h.
Aged children from 3 to 6 years: 5 ml of suspension 3 times / day with an interval of 8 h.
Aged children from 6 to 18 years: 5 ml of suspension 3-4 times a day with an interval from 6 to 8 h.
Adults: 5 ml of suspension 4 times / day with an interval of 6 hours.
Duration of treatment is 5-7 days, but not more than 7 days. If during the first 3 days of admission improvement has not come, you should consult a doctor.
Enterofuril is generally well tolerated and in rare cases can cause the following symptoms as side effects:
Allergic reactions (skin rash, urticaria, angioedema, anaphylactic shock);
Nausea;
Vomiting.
Symptoms of overdose
The active component of the suspension, Enterofuril, is not absorbed into the systemic circulation from the intestinal lumen, therefore, no facts of drug overdose have been registered to date.
Due to the content of methyl parahydroxybenzoate, the drug may cause allergic reactions (possibly delayed).
If you develop symptoms of hypersensitivity (shortness of breath, rash, itching), you should stop taking the drug. Alcohol use during therapy with nifuroxazide is prohibited.
In the treatment of diarrhea, rehydration therapy should be carried out simultaneously with therapy with Enterofuril. In the case of bacterial diarrhea with signs of systemic lesion, you should consult your doctor to decide on the use of systemic antibacterial drugs.
Enterofuril suspension contains 1000 mg of sucrose in 5 ml. Accordingly, the sucrose content in a single dose of 2.5 ml of suspension is 0.04165 XE, and in a single dose of 5 ml - 0.0833 XE.
The daily dose of sucrose is 0.0833 XE when taking 2.5 ml of suspension 2 times a day and 0.125 XE when taking 2.5 ml of suspension 3 times a day.
The content of ethanol in the preparation Enterofuril suspension is 1%. The minimum single dose of the drug, corresponding to 100 mg of nifuroxazide (2.5 ml suspension), contains 0.02 g of ethanol (based on absolute alcohol), and the maximum daily dose, corresponding to 800 mg of nifuroxazide (5 ml of suspension 4 times a day), contains 0.16 g of ethanol (in terms of absolute alcohol).
Before prescribing, it is necessary to exclude congenital deficiency of enzymes that break down sucrose in patients (including infants).
Compatibility with other drugs
Not recommended simultaneous use with drugs that cause the development of disulfiram-like reactions, drugs that suppress the function of the nervous system. If you are taking other medications (including non-prescription drugs), consult your doctor before using the drug.
We offer to read the reviews of people who used Enterofuril:
Anton. Last month, I started having colitis, which led to diarrhea. I could not cope on my own, so I turned to a doctor, for which he prescribed a medicine. I specified how many days to drink Enterofuril, and received a response - a week. After this time, all the symptoms were gone, and I began to feel much better. My feedback on capsules is positive.
Svetlana This year, she lay with her son in the infectious disease ward and she got herself a "present": vomiting, stomach cuts, and loose stools. And since in our hospitals the treatment of mothers is not supposed, we had to get out on our own. I read reviews on the forums about Enterofuril, my husband flew to the pharmacy. Took, as stated in the instructions for use. Already after two hours after the first pill, vomiting was gone, and after a day and a half I felt quite tolerable. Given the fact that I had to nurture a temperate child, I can only tell the drug a big thank you
Yura. It is not clear because of what I earned acute diarrhea, which terribly pestered me. A call to the doctor gave my results - I received a prescription for Enterofuryl. According to reviews and instructions for use, I drank capsules daily. Already the first dose alleviated the symptoms, and after 2 days everything went away, but I finished the course entirely for prevention.
Doctors reviews about Enterofuril are positive. It is well known that before prescribing an antimicrobial agent, it is necessary to accurately determine the causative agent of the disease. Modern diagnostic methods allow you to do this only for 3-10 days. Such a delay in some situations can seriously affect the condition of the patient.
The effectiveness of Enterofuril against most known microorganisms allows you to begin treatment without waiting for the results of laboratory tests. However, most doctors emphasize the fact that Enterofuril acts differently on different bacteria. In addition, in moderate doses, it stops the growth and reproduction of bacteria, in higher doses it destroys bacterial cells. However, some bacteria, destroying under the influence of the drug, emit a large amount of toxic substances for the body, which, penetrating into the systemic circulation, thus poisoning it.
Therefore, the doctor should prescribe treatment and select the optimal therapeutic dose for each specific patient. Self-medication can only aggravate the situation.
Structural analogues of the active substance:
Nifuroxazide;
Ecofuryl;
Ersefuril.
Before buying an analogue, consult your doctor.
Enterol or Enterofuril - which is better?
These are two different drugs that have certain common effects. Thus, Enterofuril is a broad-spectrum antiseptic that has a detrimental effect on the pathogenic microflora in the intestinal lumen.
For this reason, Enterofuril is widely used as a drug to treat diarrhea of ​​infectious origin. Violating the vital activity and provoking the death of microbial cells, it effectively eliminates the cause of diarrhea.
Enterol has a detrimental effect on a narrower range of microorganisms that provoke the development of diarrhea. In addition, the drug normalizes the intestinal microflora, and also increases the survival rate of lacto-and bifidobacteria. For this reason, in case of severe infectious diarrhea, which is accompanied by an increase in temperature, the appointment of Enterofuril is recommended to eliminate the cause of the development of the pathological condition.
For dysbacteriosis and diarrhea, which occurs without an increase in temperature, it is considered more rational to use Enterol for treatment, which suppresses both the symptoms of the pathological condition and normalizes the microflora in the intestinal lumen. Enterofuril is absolutely useless in this situation.
For the prevention of dysbiosis, which is a consequence of taking antibiotics, Enterol should also be taken, since Enterofuril will only enhance the effect and effect of the antibacterial drug.
Shelf life and storage conditions
There are no special requirements for the storage of Enterofuril in capsule form. The preparation in the form of a suspension is recommended to be stored in a dry place, protected from sunlight. The optimum temperature is 15-30 ° C. Do not freeze the suspension.
Suspension retains its pharmacological properties for 3 years after the release date. Shelf life after opening the bottle - no more than 14 days.
Capsules may be consumed within three years from the date of release.
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