Dietary restriction and aging in rhesus monkeys: The University of Wisconsin study
Jon J Ramsey, R. J. Colman, N. C. Binkley, J. D. Christensen, T. A. Gresl, J. W. Kemnitz, R. Weindruch
Dietary restriction (DR) retards aging and extends the maximum lifespan of laboratory mice and rats. To determine whether DR has similar actions in a primate species, we initiated a study in 1989 to investigate the effects of a 30% DR in 30 adult male rhesus monkeys. In 1994, an additional 30 females and 16 males were added to the study. Although the animals are still middle-aged, a few differences have developed between the control and DR animals suggesting that DR may induce physiologic changes in the rhesus monkey similar to those observed in rodents. Fasting basal insulin and glucose concentrations are lower in DR compared to control animals while insulin sensitivity is higher in the restricted animals. DR has also altered circulating LDL in a manner that may inhibit atherogenesis. These results suggest that DR may be slowing some age-related physiologic changes. In addition to measures of glucose and lipid metabolism, the animals are evaluated annually for body composition, energy expenditure, physical activity, hematologic indices, and blood or urinary hormone concentrations. In the next few years, the first animals will reach the average lifespan (~26 years) of captive rhesus monkeys and it will become possible to determine if DR retards the aging process and extends the lifespan in a primate species. (C) 2000 Elsevier Science Inc.
Experimental Gerontology
Lipid Metabolism
Energy expenditure
Triiodothyronine
Ramsey, J. J., Colman, R. J., Binkley, N. C., Christensen, J. D., Gresl, T. A., Kemnitz, J. W., & Weindruch, R. (2000). Dietary restriction and aging in rhesus monkeys: The University of Wisconsin study. Experimental Gerontology, 35(9-10), 1131-1149. https://doi.org/10.1016/S0531-5565(00)00166-2
Dietary restriction and aging in rhesus monkeys : The University of Wisconsin study. / Ramsey, Jon J; Colman, R. J.; Binkley, N. C.; Christensen, J. D.; Gresl, T. A.; Kemnitz, J. W.; Weindruch, R.
In: Experimental Gerontology, Vol. 35, No. 9-10, 2000, p. 1131-1149.
Ramsey, JJ, Colman, RJ, Binkley, NC, Christensen, JD, Gresl, TA, Kemnitz, JW & Weindruch, R 2000, 'Dietary restriction and aging in rhesus monkeys: The University of Wisconsin study', Experimental Gerontology, vol. 35, no. 9-10, pp. 1131-1149. https://doi.org/10.1016/S0531-5565(00)00166-2
Ramsey JJ, Colman RJ, Binkley NC, Christensen JD, Gresl TA, Kemnitz JW et al. Dietary restriction and aging in rhesus monkeys: The University of Wisconsin study. Experimental Gerontology. 2000;35(9-10):1131-1149. https://doi.org/10.1016/S0531-5565(00)00166-2
Ramsey, Jon J ; Colman, R. J. ; Binkley, N. C. ; Christensen, J. D. ; Gresl, T. A. ; Kemnitz, J. W. ; Weindruch, R. / Dietary restriction and aging in rhesus monkeys : The University of Wisconsin study. In: Experimental Gerontology. 2000 ; Vol. 35, No. 9-10. pp. 1131-1149.
@article{eac2f81753724ec6ba04ca1c5da6d6cb,
title = "Dietary restriction and aging in rhesus monkeys: The University of Wisconsin study",
abstract = "Dietary restriction (DR) retards aging and extends the maximum lifespan of laboratory mice and rats. To determine whether DR has similar actions in a primate species, we initiated a study in 1989 to investigate the effects of a 30{\%} DR in 30 adult male rhesus monkeys. In 1994, an additional 30 females and 16 males were added to the study. Although the animals are still middle-aged, a few differences have developed between the control and DR animals suggesting that DR may induce physiologic changes in the rhesus monkey similar to those observed in rodents. Fasting basal insulin and glucose concentrations are lower in DR compared to control animals while insulin sensitivity is higher in the restricted animals. DR has also altered circulating LDL in a manner that may inhibit atherogenesis. These results suggest that DR may be slowing some age-related physiologic changes. In addition to measures of glucose and lipid metabolism, the animals are evaluated annually for body composition, energy expenditure, physical activity, hematologic indices, and blood or urinary hormone concentrations. In the next few years, the first animals will reach the average lifespan (~26 years) of captive rhesus monkeys and it will become possible to determine if DR retards the aging process and extends the lifespan in a primate species. (C) 2000 Elsevier Science Inc.",
keywords = "Aging, Body composition, Bone, Calorie restriction, Energy expenditure, Glucose, Insulin, Leptin, Physical activity, Triiodothyronine",
author = "Ramsey, {Jon J} and Colman, {R. J.} and Binkley, {N. C.} and Christensen, {J. D.} and Gresl, {T. A.} and Kemnitz, {J. W.} and R. Weindruch",
journal = "Experimental Gerontology",
number = "9-10",
T1 - Dietary restriction and aging in rhesus monkeys
T2 - The University of Wisconsin study
AU - Ramsey, Jon J
AU - Colman, R. J.
AU - Binkley, N. C.
AU - Christensen, J. D.
AU - Gresl, T. A.
AU - Kemnitz, J. W.
AU - Weindruch, R.
N2 - Dietary restriction (DR) retards aging and extends the maximum lifespan of laboratory mice and rats. To determine whether DR has similar actions in a primate species, we initiated a study in 1989 to investigate the effects of a 30% DR in 30 adult male rhesus monkeys. In 1994, an additional 30 females and 16 males were added to the study. Although the animals are still middle-aged, a few differences have developed between the control and DR animals suggesting that DR may induce physiologic changes in the rhesus monkey similar to those observed in rodents. Fasting basal insulin and glucose concentrations are lower in DR compared to control animals while insulin sensitivity is higher in the restricted animals. DR has also altered circulating LDL in a manner that may inhibit atherogenesis. These results suggest that DR may be slowing some age-related physiologic changes. In addition to measures of glucose and lipid metabolism, the animals are evaluated annually for body composition, energy expenditure, physical activity, hematologic indices, and blood or urinary hormone concentrations. In the next few years, the first animals will reach the average lifespan (~26 years) of captive rhesus monkeys and it will become possible to determine if DR retards the aging process and extends the lifespan in a primate species. (C) 2000 Elsevier Science Inc.
AB - Dietary restriction (DR) retards aging and extends the maximum lifespan of laboratory mice and rats. To determine whether DR has similar actions in a primate species, we initiated a study in 1989 to investigate the effects of a 30% DR in 30 adult male rhesus monkeys. In 1994, an additional 30 females and 16 males were added to the study. Although the animals are still middle-aged, a few differences have developed between the control and DR animals suggesting that DR may induce physiologic changes in the rhesus monkey similar to those observed in rodents. Fasting basal insulin and glucose concentrations are lower in DR compared to control animals while insulin sensitivity is higher in the restricted animals. DR has also altered circulating LDL in a manner that may inhibit atherogenesis. These results suggest that DR may be slowing some age-related physiologic changes. In addition to measures of glucose and lipid metabolism, the animals are evaluated annually for body composition, energy expenditure, physical activity, hematologic indices, and blood or urinary hormone concentrations. In the next few years, the first animals will reach the average lifespan (~26 years) of captive rhesus monkeys and it will become possible to determine if DR retards the aging process and extends the lifespan in a primate species. (C) 2000 Elsevier Science Inc.
KW - Bone
KW - Calorie restriction
KW - Energy expenditure
KW - Leptin
KW - Physical activity
KW - Triiodothyronine
JO - Experimental Gerontology
JF - Experimental Gerontology
IS - 9-10