Lunelle
Lunelle Side Effects
Generic name: estradiol / medroxyprogesterone
Medically reviewed by Drugs.com. Last updated on Oct 1, 2022.
Note: This document contains side effect information about estradiol / medroxyprogesterone. Some dosage forms listed on this page may not apply to the brand name Lunelle.
Applies to estradiol / medroxyprogesterone: intramuscular suspension.
Cardiovascular side effects have included elevated blood pressure, arterial thromboembolism, cerebral hemorrhage, cerebral thrombosis and myocardial infarction.[Ref]
Genitourinary
Genitourinary side effects have included amenorrhea, dysmenorrhea, menorrhagia, metrorrhagia, vaginal spotting, vaginal moniliasis, vulvovaginal disorder, breast changes (enlargement, secretion, tenderness, pain), decreased libido and cervical changes. When estradiol-medroxyprogesterone injection is given immediately postpartum, a diminution in lactation has been reported. Temporary infertility has been reported after treatment discontinuation.[Ref]
Hematologic
Hematologic side effects have included arterial thromboembolism, cerebral hemorrhage, cerebral thrombosis, thrombophlebitis, pulmonary embolism, mesenteric thrombosis and retinal thrombosis.[Ref]
Gastrointestinal side effects have included abdominal pain, enlarged abdomen and nausea.[Ref]
Metabolic side effects have included reduced carbohydrate tolerance, weight gain, and weight loss.[Ref]
Hepatic side effects have included hepatic adenomas or begin liver tumors, gallbladder disease and cholestatic jaundice.[Ref]
Nervous system side effects have included dizziness, headache, nervousness and migraine.[Ref]
General side effects have included edema and asthenia.[Ref]
Ocular side effects have included retinal thrombosis, corneal curvature changes (i.e., steeping), and intolerance to contact lenses.[Ref]
Dermatologic side effects have included acne, alopecia and melasma that may persist.[Ref]
Respiratory side effects have included pulmonary embolism.[Ref]
Psychiatric side effects have included depression, nervousness, and emotional lability.[Ref]
Hypersensitivity side effects have included anaphylactic reactions and rash.[Ref]
More about Lunelle (estradiol / medroxyprogesterone)
Drug class: contraceptives
1. "Product Information. Lunelle (estradiol-medroxyprogesterone)." Pharmacia and Upjohn (2001):
Availability Discontinued
Pregnancy & Lactation Risk data available
Approval History Drug history at FDA
norethindrone, Nexplanon, medroxyprogesterone, levonorgestrel, Depo-Provera, Yaz