Matrix Metalloproteinase 28-Bearing Microcystic Adnexal Carcinoma on the Back
Hiromu Chiba, Yumi Kambayashi, Erika Tamabuchi, Akira Hashimoto, Taku Fujimura
MED - Medical Sciences
Sense Organs and Rehabilitation Medicine
Although microcystic adnexal carcinoma (MAC) recurs and expands locally without metastases to the lymph nodes and other organs, its biological behavior remains unknown. In this report, a case of a giant MAC on the back treated with radical excision and curative radiation therapy and its characteristic dermoscopic findings are presented. In addition, immunohistochemical staining showed the expression of matrix metalloproteinase (MMP) 28 on the tumor cells and MMP12 and periostin in the stroma. The present case suggests the possible biological behaviors of MAC and might provide a possible target for the treatment of MAC in the future.
Case Reports in Oncology
https://doi.org/10.1159/000520971
Local recurrence
Matrix metalloproteinase 28
Microcystic adnexal carcinoma
Nerve infiltration
Radiation resistant
10.1159/000520971
Dive into the research topics of 'Matrix Metalloproteinase 28-Bearing Microcystic Adnexal Carcinoma on the Back'. Together they form a unique fingerprint.
Microcystic adnexal carcinoma Medicine & Life Sciences 100%
Back Medicine & Life Sciences 56%
Matrix Metalloproteinases Medicine & Life Sciences 54%
Radiotherapy Medicine & Life Sciences 9%
Staining and Labeling Medicine & Life Sciences 9%
Neoplasm Metastasis Medicine & Life Sciences 8%
Chiba, H., Kambayashi, Y., Tamabuchi, E., Hashimoto, A., & Fujimura, T. (Accepted/In press). Matrix Metalloproteinase 28-Bearing Microcystic Adnexal Carcinoma on the Back. Case Reports in Oncology, 1773-1778. https://doi.org/10.1159/000520971
Matrix Metalloproteinase 28-Bearing Microcystic Adnexal Carcinoma on the Back. / Chiba, Hiromu; Kambayashi, Yumi; Tamabuchi, Erika; Hashimoto, Akira; Fujimura, Taku.
In: Case Reports in Oncology, 2021, p. 1773-1778.
Chiba, H, Kambayashi, Y, Tamabuchi, E, Hashimoto, A & Fujimura, T 2021, 'Matrix Metalloproteinase 28-Bearing Microcystic Adnexal Carcinoma on the Back', Case Reports in Oncology, pp. 1773-1778. https://doi.org/10.1159/000520971
Chiba H, Kambayashi Y, Tamabuchi E, Hashimoto A, Fujimura T. Matrix Metalloproteinase 28-Bearing Microcystic Adnexal Carcinoma on the Back. Case Reports in Oncology. 2021;1773-1778. https://doi.org/10.1159/000520971
Chiba, Hiromu ; Kambayashi, Yumi ; Tamabuchi, Erika ; Hashimoto, Akira ; Fujimura, Taku. / Matrix Metalloproteinase 28-Bearing Microcystic Adnexal Carcinoma on the Back. In: Case Reports in Oncology. 2021 ; pp. 1773-1778.
@article{5ba0589c48d745c4bab99f85c4544bbb,
title = "Matrix Metalloproteinase 28-Bearing Microcystic Adnexal Carcinoma on the Back",
abstract = "Although microcystic adnexal carcinoma (MAC) recurs and expands locally without metastases to the lymph nodes and other organs, its biological behavior remains unknown. In this report, a case of a giant MAC on the back treated with radical excision and curative radiation therapy and its characteristic dermoscopic findings are presented. In addition, immunohistochemical staining showed the expression of matrix metalloproteinase (MMP) 28 on the tumor cells and MMP12 and periostin in the stroma. The present case suggests the possible biological behaviors of MAC and might provide a possible target for the treatment of MAC in the future. ",
keywords = "Local recurrence, Matrix metalloproteinase 28, Microcystic adnexal carcinoma, Nerve infiltration, Radiation resistant",
author = "Hiromu Chiba and Yumi Kambayashi and Erika Tamabuchi and Akira Hashimoto and Taku Fujimura",
note = "Funding Information: This study was supported in part by the Japan Agency for Medical Research and Development (21ym0126041h0001). Publisher Copyright: {\textcopyright} 2021 The Author(s). Published by S. Karger AG, Basel. This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC).",
doi = "10.1159/000520971",
journal = "Case Reports in Oncology",
publisher = "S. Karger AG",
T1 - Matrix Metalloproteinase 28-Bearing Microcystic Adnexal Carcinoma on the Back
AU - Chiba, Hiromu
AU - Kambayashi, Yumi
AU - Tamabuchi, Erika
AU - Hashimoto, Akira
AU - Fujimura, Taku
N1 - Funding Information: This study was supported in part by the Japan Agency for Medical Research and Development (21ym0126041h0001). Publisher Copyright: © 2021 The Author(s). Published by S. Karger AG, Basel. This article is licensed under the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC).
N2 - Although microcystic adnexal carcinoma (MAC) recurs and expands locally without metastases to the lymph nodes and other organs, its biological behavior remains unknown. In this report, a case of a giant MAC on the back treated with radical excision and curative radiation therapy and its characteristic dermoscopic findings are presented. In addition, immunohistochemical staining showed the expression of matrix metalloproteinase (MMP) 28 on the tumor cells and MMP12 and periostin in the stroma. The present case suggests the possible biological behaviors of MAC and might provide a possible target for the treatment of MAC in the future.
AB - Although microcystic adnexal carcinoma (MAC) recurs and expands locally without metastases to the lymph nodes and other organs, its biological behavior remains unknown. In this report, a case of a giant MAC on the back treated with radical excision and curative radiation therapy and its characteristic dermoscopic findings are presented. In addition, immunohistochemical staining showed the expression of matrix metalloproteinase (MMP) 28 on the tumor cells and MMP12 and periostin in the stroma. The present case suggests the possible biological behaviors of MAC and might provide a possible target for the treatment of MAC in the future.
KW - Local recurrence
KW - Matrix metalloproteinase 28
KW - Microcystic adnexal carcinoma
KW - Nerve infiltration
KW - Radiation resistant
U2 - 10.1159/000520971
DO - 10.1159/000520971
JO - Case Reports in Oncology
JF - Case Reports in Oncology