A case report of severe panhypopituitarism in a newborn delivered by a women with Turner syndrome.
Olszewska M, Kiełbasa G, Wójcik M, Zygmunt-Górska A, Starzyk J.
Case Reports 2015; 36(8): 734-736 PubMed PMID: 26921572 Citation Keywords: Antidiuretic Agents:therapeutic use, Deamino Arginine Vasopressin:therapeutic use, Female, Hormone Replacement Therapy:methods, Human Growth Hormone:therapeutic use, Humans, Hydrocortisone:therapeutic use, Hypopituitarism:diagnosis, Infant, Newborn, Magne.
: Turner syndrome (TS) is a congenital disease caused by absence or structural abnormalities of sex chromosomes resulting in gonadal dysgenesis. Spontaneous pregnancies occur in 2-8% of patients, especially with mosaic kariotypes, however they are associated with increased risk of poor outcome both for mother and fetus. We report a 4-day-old male infant delivered by women with mosaic TS who was admitted to the pediatric intensive care unit and presented with severe panhypopituitarism as the early manifestation of pituitary stalk interruption syndrome (PSIS). To the best of our knowledge this is the first report of severe panhypopituitarism in a newborn borne by women with TS....
Olszewska M, Kiełbasa G, Wójcik M, Zygmunt-Górska A, Starzyk J. A case report of severe panhypopituitarism in a newborn delivered by a women with Turner syndrome. Neuro Endocrinol Lett. 2015 Jan; 36(8): 734-736
Selected areas of health and health care utilization by immigrants living in the Czech Republic.
Brabcová I, Kajanová A.
Journal Article 2015; 36(Suppl 2): 48-53 PubMed PMID: 26748527 Citation Keywords: Adult, Czech Republic, Emigrants and Immigrants:statistics & numerical data, Female, Hospitalization:statistics & numerical data, Humans, Insurance, Health:statistics & numerical data, Male, Middle Aged, Patient Acceptance of Health Care:ethnology, Young .
OBJECTIVE: This investigation examined to what extent a selected group of immigrants in the Czech Republic receive healthcare for primary prevention and inpatient care. A partial aim of the research was to confirm the connection between immigrant health and their social situation.
METHODS: Using a quantitative study technique, 1,014 legally established immigrants (Vietnamese, Polish, Ukrainian, Russian, and Slovak) between 18-65 years of age were interviewed. The selection of respondents was conducted using purposive selection. The stratification of the group was determined by nationality, age, and gender.
RESULTS: Long-term illnesses were found significantly more frequently among Ukrainian immigrants and less frequently among Vietnamese immigrants. About half of the respondents had visited a GP and dentist in the previous year and 11.5% of respondents had been hospitalized in inpatient departments. Most of the surveyed immigrants had public health insurance (77.9%), one-fifth had contractual health insurance (19.6%) and 2.5% did not have health insurance. In statistical terms, Vietnamese, Ukrainian, and Russian immigrants had commercial insurance more often than Polish and Slovak immigrants. The utilization of public health insurance and healthcare among immigrants grew significantly in correlation with length of residency. The use of GPs for preventive health care also grew in correlation with knowledge of the Czech language. We found that less than nine percent of immigrants reported needing hospitalization for an illness, but were not hospitalized.
CONCLUSION: Currently, immigration represents one of the most burning and sensitive global challenges. The outcome of this research clearly shows that improving immigrant Czech language skills and giving all legally established immigrants access to Czech public health insurance are important steps needed to increase access to healthcare for immigrants in the Czech Republic....
Brabcová I, Kajanová A. Selected areas of health and health care utilization by immigrants living in the Czech Republic. Neuro Endocrinol Lett. 2015 Jan; 36(Suppl 2): 48-53
Prevention of patient falls in hospitals in the Czech Republic.
Brabcová I, Bártlová S, Hajduchová H, Tóthová V.
Journal Article 2015; 36(Suppl 2): 23-28 PubMed PMID: 26748523 Citation Keywords: Accidental Falls:prevention & control, Adult, Czech Republic, Female, Health Care Surveys, Hospitals:standards, Humans, Inpatients, Middle Aged, Nursing Staff, Hospital, Patient Safety:standards,.
THEORY: The prevention of patient falls is one of the safety goals set forth by the Ministry of Health of the Czech Republic.
GOAL: A sociological survey was carried out to (1) determine to what extent nurses identify the risk of patient falls at admission, (2) if the risk is reassessed and at what intervals, (3) what preventive measures were taken, and (4) in what way are patient falls reported.
METHODOLOGY: A representative sample consisting of general nurses working shifts on inpatient wards at hospitals in the Czech Republic was surveyed. Altogether 772 nurses took part in the study.
RESULTS: The survey showed that at admission, most nurses assessed the risk of falls (91.6%). Nonetheless, it should stand as a stark warning that nearly one fifth of the respondents (16.2%) did not reassess the risk of falls after admission! On the other hand, it can be perceived as a positive that most nurses (70.1%) use a multifaceted program of preventive measures for at risk patients and immediately reported fall events to the doctor in charge (71.4%). During statistical testing, the predication that a working atmosphere supporting a culture of patient safety would significantly decrease the probability of patient falls and increases the willingness of nurses to use preventive programs in daily practice.
CONCLUSION: Results from the survey showed that a system to minimalize fall risks has been successfully introduced into the hospitals of the Czech Republic. The system is based on the recommendations of the Ministry of Health of the Czech Republic....
Brabcová I, Bártlová S, Hajduchová H, Tóthová V. Prevention of patient falls in hospitals in the Czech Republic. Neuro Endocrinol Lett. 2015 Jan; 36(Suppl 2): 23-28
Patient misidentification in nursing care.
Bártlová S, Hajduchová H, Brabcová I, Tóthová V.
Journal Article 2015; 36(Suppl 2): 17-22 PubMed PMID: 26748522 Citation Keywords: Adult, Czech Republic, Female, Health Care Surveys:statistics & numerical data, Humans, Medical Errors:statistics & numerical data, Middle Aged, Nurses:standards, Nursing Staff, Hospital:standards, Patient Safety:standards,.
GOAL: The goal of the study was to assess the opinions of nurses regarding patient safety associated with patient misidentification. The investigation was focused on actual patient misidentification as well as loss of patient materials (e.g., blood samples, X-rays, etc.). These are problems often associated with patient identification methods and/or confusing patients with the same surname assigned to the same ward. The risks of misidentification incidents pose a considerable threat to patient health especially when the confusion extends to the operating room. Our objective was to identify the potential causes of patient misidentification and offers solutions to correct the issue.
METHODS: A survey as part of a sociological investigation was carried out through the use of questionnaires. The selected sample included, in accordance with the needs of the project and methodology of the Institute for Health Care Information and Statistics of the Czech Republic, registered nurses working shifts on inpatient wards. The study took place across the Czech Republic between Sept. 15 and 30, 2013. The sample consisted of 772 registered nurses.
RESULTS: The potential for patient misidentification (PM) was described as negligible by 73.8% of respondents. Only 9.1% of nurses admitted problems associated with patient misidentification. Respondents reported that the greatest potential for patient misidentification was associated with patients having the same surname staying on the same ward. An absolute majority of nurses responded that patient identification wristbands were the most frequently used method to prevent PM. Over 90% (90.6%) of nurses reported that patient ID wristbands were used for all patients. Almost 80% (77.4%) reported the use of positive verbal identification in addition to ID wrist bands. Respondents reported (76.2%) that the most frequently used method to avoid PM in the operating room involved a review of patient documentation. Almost the same number of repondents (74.1%) reported the use of verbal confirmation as a method to avoid PM. Another mechanism included verification of the surgical procedure. ID wristbands and completion of an 'identification protocol' rank among other options mentioned most frequently by respondents.
CONCLUSION: The study shows that registered nurses regard patient misidentification as a very rare and unlikely event. Nonetheless, statistics suggest otherwise and education, changes in protocols, and new technologies are needed to improve the precision of patient identification....
Bártlová S, Hajduchová H, Brabcová I, Tóthová V. Patient misidentification in nursing care. Neuro Endocrinol Lett. 2015 Jan; 36(Suppl 2): 17-22
Selected aspects of "safety culture" in hospitals of the Czech Republic.
Brabcová I, Bártlová S, Tóthová V, Prokešová R.
Journal Article 2015; 36(Suppl 2): 11-16 PubMed PMID: 26748521 Citation Keywords: Adult, Attitude of Health Personnel, Czech Republic, Female, Hospitals:standards, Humans, Middle Aged, Nursing Staff, Hospital:statistics & numerical data, Organizational Culture, Patient Safety:standards,.
THEORETICAL BACKGROUND: Patient safety is a strategic goal of managers of all health care facilities in the Czech Republic. The development of a safety culture in the facility helps to ensure high quality health care. GOAL OF THE SURVEY was to assess the safety culture with regard to patient safety and team cooperation. A partial goal was to confirm the hypothesis that team cooperation among health care staff significantly influences patient safety.
METHODOLOGY: 772 nurses took part in a quantitative survey. The respondents were nurses working shifts in inpatient departments of hospitals in the Czech Republic.
RESULTS: Patient safety was described as excellent by 17.5% of nurses. It is described as very good by 60.2% of nurses and described as acceptable by 20.5% nurses. 78% of respondents agreed with the statement that patient safety was never neglected at the expense of increased workload. More than 10% of nurses reported that there were problems with patient safety. 19.8% of respondents were reported that efforts to prevent errors were not practiced at their clinic, and, therefore, and only chance had prevent more errors from occurring. According to 64.9% of respondents, the staff on the wards supported each other and a similar number of respondents reported that they showed respect for each other (60.2%). Respondents reported that intra-ward support increased the degree of patient safety.
CONCLUSION: Results from the survey show that team cooperation is a precondition for providing safe patient care, which cannot be underestimated and must be refined and improved through good hospital management....
Brabcová I, Bártlová S, Tóthová V, Prokešová R. Selected aspects of "safety culture" in hospitals of the Czech Republic. Neuro Endocrinol Lett. 2015 Jan; 36(Suppl 2): 11-16
Microsatellite instability analysis in pituitary adenomas.
Bujko M, Kober P, Zbijewska J, Kunicki J, Bonicki W.
Journal Article 2015; 36(5): 511-514 PubMed PMID: 26707053 Citation Keywords: ACTH-Secreting Pituitary Adenoma:genetics, Adenoma:genetics, Adult, Aged, Aged, 80 and over, Biomarkers, Tumor:genetics, Cohort Studies, Electrophoresis, Capillary, Female, Growth Hormone-Secreting Pituitary Adenoma:genetics, Humans, Male, Microsatellite .
OBJECTIVE: Mutator phenotypes with microsatellite instability (MSI) are observed in a subset of solid tumors including those localized in the brain. MSI arises from impaired DNA mismatch repair. It can be a potential marker of resistance to radiation and chemotherapy, as demonstrated for several cancer types. Our study aims are to investigate MSI incidence in pituitary adenomas (PA) with a currently recommended methodology.
METHODS: DNA was obtained from 107 patients with PA of which 83 adenomas were nonfunctioning, 13 somatotrophic, 9 lactotrophic and 2 corticotrophic. These were examined for MSI status by PCR and capillary electrophoresis using five quasimonomorphic microsatellite markers: BAT25, BAT26, NR21, NR24 and NR27; in accordance to current Bethesda guidelines.
RESULTS AND CONCLUSION: No microsatellite instability was detected in the tumor samples thus implying the lack of any clinical usefulness of MSI testing in PA cases....
Bujko M, Kober P, Zbijewska J, Kunicki J, Bonicki W. Microsatellite instability analysis in pituitary adenomas. Neuro Endocrinol Lett. 2015 Jan; 36(5): 511-514
Sonic hedgehog overexpression regulates the neuroepithelial cells proliferation in the spinal cord of dorsal regions during chicken embryo development.
Yang C, Li X, Liu Y, Li H, Guo Z, Lin J.
Journal Article 2015; 36(4): 380-386 PubMed PMID: 26454495 Citation Keywords: Animals, Chick Embryo:growth & development, Chickens:growth & development, Embryonic Development:genetics, Gene Expression Regulation, Developmental:genetics, Hedgehog Proteins:metabolism, Neuroepithelial Cells:physiology, Spinal Cord:growth & development.
OBJECTIVE: Sonic hedgehog(SHH) is early expressed in the floor plate and notochord during the development of chicken embryo, which is required for the establishment of dorsal axis and the formation of spinal cord, but the mechanism of SHH affecting the patterns of spinal development is still unclear.
METHODS: In this study using in vivo electroporation ectopic expression of SHH in spinal cord of dorsal regions during chicken embryo development. Besides, the expression of NF, TAG, Pax-7 and N-Cadherin was examined by the fluorescent immunohistochemistry.
RESULTS: The result showed that the pattern of spinal cord development changed such as the distortion was observed during the chicken embryo development, and the location of dorsal root transforms from the original site to the roof plate, and neuroepithelial cell layer at the roof plate creased. Furthermore, the expression of nuclear protein Pax-7 was inhibited at the site of SHH ectopic and the expression site of neurofilament(NF) and TAG-1 changed, while the expression of SC-1 was down-regulated.
CONCLUSIONS: This study demonstrated that SHH may be directly required for the formation of spinal patterns or affect the formation of spinal cord through regulating the associated proteins and more important is SHH promote the neuroepithelial cells proliferation and then lead to neural plate to form the neural tube. This study could provide reliable references for the research on SHH determining the formation of spinal cord during the development of chicken embryo....
Yang C, Li X, Liu Y, Li H, Guo Z, Lin J. Sonic hedgehog overexpression regulates the neuroepithelial cells proliferation in the spinal cord of dorsal regions during chicken embryo development. Neuro Endocrinol Lett. 2015 Jan; 36(4): 380-386
Expression of voltage gated potassium channel ether à go-go in pituitary adenomas of patients with acromegaly: A preliminary study.
Zuhur S, Ozkayalar H, Kuzu I, Ozturk F, Elbuken G, Tanik C, Altuntas Y.
Journal Article 2015; 36(2): 165-170 PubMed PMID: 26071586 Citation Keywords: Adult, Aged, Ether-A-Go-Go Potassium Channels:metabolism, Growth Hormone-Secreting Pituitary Adenoma:metabolism, Humans, Ki-67 Antigen:metabolism, Male, Middle Aged, Pilot Projects, Young Adult,.
OBJECTIVE: To determine immunohistochemical expression of Eag1 in pituitary adenomas of patients with acromegaly and to assess the correlation between Eag1 expression with cavernous sinus invasion, tumoral Ki-67 labeling index (LI), age and gender of the patients.
METHODS: The paraffin embedded pituitary adenoma tissue sections of 28 patients with acromegaly who were diagnosed as monohormonal growth hormone (GH) secreting adenomas were immunostained for Eag1 using the avidin-biotin-peroxidase complex method. Eag1 immunoreactivity was scored according to the extensity of the cytoplasm and cell membrane immunoreactivity for Eag1 (score 1 = <10%, score 2 = 10-25%, score 3 = 25-50% and score 4 = >50% of the adenoma cells showed immunoreactivity for Eag1, respectively).
RESULTS: Overall, GH secreting pituitary adenomas displayed diverse levels of Eag1 immunoreactivity, however, 64% of the adenomas displayed a strong Eag1 immunoreactivity (score 3 and 4). Five of the tumors displayed Eag1 immunoreactivity score 1, 5 displayed score 2, 10 displayed score 3 and 8 displayed score 4, respectively. No correlation was found between Eag1 immunoreactivity with cavernous sinus invasion, Ki-67 LI, age and gender of the patients.
CONCLUSIONS: Our results suggest Eag1 is strongly expressed in the majority of GH secreting pituitary adenomas. However, we could not find any correlation between immunoreactivity of Eag1 with cavernous sinus invasion, Ki-67 LI, age and gender of the patients. Further studies with larger sample sizes are required to demonstrate the role of Eag1 on tumorigenesis, angiogenesis, invasion and response to the treatment in GH secreting pituitary adenomas....
Zuhur S, Ozkayalar H, Kuzu I, Ozturk F, Elbuken G, Tanik C, Altuntas Y. Expression of voltage gated potassium channel ether à go-go in pituitary adenomas of patients with acromegaly: A preliminary study. Neuro Endocrinol Lett. 2015 Jan; 36(2): 165-170