July-August 2005 - Volume 12 - Issue 4
Thought you might appreciate this item(s) I saw at American Journal of Therapeutics.
Colesevelam HCl and Ezetimibe Combination Therapy Provides Effective Lipid-Lowering in Difficult-to-Treat Patients with Hypercholesterolemia
Zema, Michael J
Division of Cardiology, Department of Medicine, Brookhaven Memorial Hospital Medical Center, Patchogue, New York; and State University of New York, Stony Brook, New York.
The publication of this study was supported by a grant from Sankyo Pharma Inc.; however, no financial support was provided by any pharmaceutical company or any other outside agency for the conducting of the study.
Address for correspondence: Brookhaven Memorial Hospital Medical Center, 101 Hospital Road, Patchogue, NY 11772. E-mail: [email protected]
American Journal of Therapeutics: July 2005 - Volume 12 - Issue 4 - p 306-310
doi: 10.1097/01.mjt.0000155109.69831.a3
This study investigated the effects of colesevelam hydrochloride (WelChol; Sankyo Pharma, Parsippany, NJ) and ezetimibe (Zetia; Merck/Schering Plough Pharmaceuticals, North Wales, PA), alone and in combination, for the treatment of hypercholesterolemia in patients who were intolerant to, or refused, HMG-Co-A reductase inhibitor (statin) therapy. Combination therapy with colesevelam HCl/ezetimibe resulted in an additional reduction in low-density lipoprotein cholesterol (LDL-C) and non-high-density lipoprotein cholesterol (HDL-C) levels of approximately 20% (P < 0.005) and 16% (P < 0.01), respectively, compared with monotherapy with either agent. Total cholesterol, LDL-C, and non-HDL-C levels were within National Cholesterol Education Program Adult Treatment Panel III target ranges at the end of the combination therapy regimen in 10 of 12 patients. In conclusion, colesevelam HCl/ezetimibe combination therapy appears to be an efficacious and well-tolerated alternative for patients with hypercholesterolemia.
© 2005 Lippincott Williams & Wilkins, Inc.
American Journal of Therapeutics12(4):306-310, July-August 2005.
colesevelam , ezetimibe , hypercholesterolemia , statin
colesevelam\r, ezetimibe\r, hypercholesterolemia\r, statin
Articles in PubMed by Michael J Zema
Articles in Google Scholar by Michael J Zema
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