Immunol Cell Biol. 2000 Aug;78(4):318-24.
Interaction of dendritic cells with mycobacteria: where the action starts.
Demangel C1, Britton WJ.
Centenary Institute of Cancer Medicine and Cell Biology, University of Sydney, Department of Medicine, Sydney, New South Wales, Australia.
Dendritic cells (DC) are the major antigen-presenting cells in the induction of cellular responses to intracellular pathogens, such as mycobacteria. Recent studies have shown that they also play a critical role in the regulation of immune responses. The interaction of DC with microbial antigens may be the controlling factor in the development of a Th1-orientated protective immunity. Analysis of the innate response of DC to mycobacteria and the involvement of the DC receptors in antigen recognition have highlighted the pivotal role of these cells in T-cell activation. Mycobacteria-infected DC have an enhanced capacity to release pro-inflammatory cytokines and chemokines and are potent inducers of interferon-gamma-producing cells in vivo. Therefore, DC manipulation for maximal antigen presentation and Th1 cytokine production may form the basis of a new generation of vaccines, with improved efficacy against mycobacterial infections.
BCG Vaccine/immunology
Cell Communication
Chemokines/immunology
Cytokines/immunology*
Dendritic Cells/immunology*
Dendritic Cells/microbiology
Interleukin-10/deficiency
Interleukin-10/genetics
Lymphocyte Activation
Mice, Knockout
Mycobacterium/immunology*
Receptors, Immunologic/immunology
T-Lymphocytes/immunology
Th1 Cells/immunology
BCG Vaccine
Receptors, Immunologic
Interleukin-10