Preconditioning: Gender effects
Jeffrey M. Pitcher, Meijing Wang, Ben M. Tsai, Ajay Kher, Mark Turrentine, John Brown, Daniel R. Meldrum
Preconditioning is injury induced protection from subsequent injury. During preconditioning protective cellular responses to injury are up regulated resulting in acute and delayed defense against further damage. Several studies indicate that females experience a protective advantage after acute insult compared to males. Despite evidence of gender differences in acute injury, relatively few studies have evaluated whether there are sex differences in preconditioning. Variations in patients' pre-morbid preconditioning status may explain outcome variations that are not apparent in small animal studies. This review discusses the differences in response to acute injury experienced by males and females, the basic mechanisms of preconditioning, and the sex differences in the mechanisms of preconditioning.
Journal of Surgical Research
https://doi.org/10.1016/j.jss.2005.04.015
Acute injury
Pitcher, J. M., Wang, M., Tsai, B. M., Kher, A., Turrentine, M., Brown, J., & Meldrum, D. R. (2005). Preconditioning: Gender effects. Journal of Surgical Research, 129(2), 202-220. https://doi.org/10.1016/j.jss.2005.04.015
Preconditioning : Gender effects. / Pitcher, Jeffrey M.; Wang, Meijing; Tsai, Ben M.; Kher, Ajay; Turrentine, Mark; Brown, John; Meldrum, Daniel R.
In: Journal of Surgical Research, Vol. 129, No. 2, 12.2005, p. 202-220.
Pitcher, JM, Wang, M, Tsai, BM, Kher, A, Turrentine, M, Brown, J & Meldrum, DR 2005, 'Preconditioning: Gender effects', Journal of Surgical Research, vol. 129, no. 2, pp. 202-220. https://doi.org/10.1016/j.jss.2005.04.015
Pitcher JM, Wang M, Tsai BM, Kher A, Turrentine M, Brown J et al. Preconditioning: Gender effects. Journal of Surgical Research. 2005 Dec;129(2):202-220. https://doi.org/10.1016/j.jss.2005.04.015
Pitcher, Jeffrey M. ; Wang, Meijing ; Tsai, Ben M. ; Kher, Ajay ; Turrentine, Mark ; Brown, John ; Meldrum, Daniel R. / Preconditioning : Gender effects. In: Journal of Surgical Research. 2005 ; Vol. 129, No. 2. pp. 202-220.
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title = "Preconditioning: Gender effects",
abstract = "Preconditioning is injury induced protection from subsequent injury. During preconditioning protective cellular responses to injury are up regulated resulting in acute and delayed defense against further damage. Several studies indicate that females experience a protective advantage after acute insult compared to males. Despite evidence of gender differences in acute injury, relatively few studies have evaluated whether there are sex differences in preconditioning. Variations in patients' pre-morbid preconditioning status may explain outcome variations that are not apparent in small animal studies. This review discusses the differences in response to acute injury experienced by males and females, the basic mechanisms of preconditioning, and the sex differences in the mechanisms of preconditioning.",
keywords = "Acute injury, Inflammation, Sex, Tolerance",
author = "Pitcher, {Jeffrey M.} and Meijing Wang and Tsai, {Ben M.} and Ajay Kher and Mark Turrentine and John Brown and Meldrum, {Daniel R.}",
doi = "10.1016/j.jss.2005.04.015",
journal = "Journal of Surgical Research",
T1 - Preconditioning
T2 - Gender effects
AU - Pitcher, Jeffrey M.
AU - Wang, Meijing
AU - Tsai, Ben M.
AU - Kher, Ajay
AU - Turrentine, Mark
AU - Brown, John
AU - Meldrum, Daniel R.
N2 - Preconditioning is injury induced protection from subsequent injury. During preconditioning protective cellular responses to injury are up regulated resulting in acute and delayed defense against further damage. Several studies indicate that females experience a protective advantage after acute insult compared to males. Despite evidence of gender differences in acute injury, relatively few studies have evaluated whether there are sex differences in preconditioning. Variations in patients' pre-morbid preconditioning status may explain outcome variations that are not apparent in small animal studies. This review discusses the differences in response to acute injury experienced by males and females, the basic mechanisms of preconditioning, and the sex differences in the mechanisms of preconditioning.
AB - Preconditioning is injury induced protection from subsequent injury. During preconditioning protective cellular responses to injury are up regulated resulting in acute and delayed defense against further damage. Several studies indicate that females experience a protective advantage after acute insult compared to males. Despite evidence of gender differences in acute injury, relatively few studies have evaluated whether there are sex differences in preconditioning. Variations in patients' pre-morbid preconditioning status may explain outcome variations that are not apparent in small animal studies. This review discusses the differences in response to acute injury experienced by males and females, the basic mechanisms of preconditioning, and the sex differences in the mechanisms of preconditioning.
KW - Acute injury
KW - Inflammation
KW - Sex
KW - Tolerance
U2 - 10.1016/j.jss.2005.04.015
DO - 10.1016/j.jss.2005.04.015
JO - Journal of Surgical Research
JF - Journal of Surgical Research
10.1016/j.jss.2005.04.015