Fluorescence lifetime in cardiovascular diagnostics
Laura Marcu
We review fluorescence lifetime techniques including timeresolved laser-induced fluorescence spectroscopy (TR-LIFS) and fluorescence lifetime imaging microscopy (FLIM) instrumentation and associated methodologies that allow for characterization and diagnosis of atherosclerotic plaques. Emphasis is placed on the translational research potential of TR-LIFS and FLIM and on determining whether intrinsic fluorescence signals can be used to provide useful contrast for the diagnosis of high-risk atherosclerotic plaque. Our results demonstrate that these techniques allow for the discrimination of important biochemical features involved in atherosclerotic plaque instability and rupture and show their potential for future intravascular applications.
life (durability)
laser induced fluorescence
Microscopic examination
Atherosclerotic plaques
Fluorescence lifetime imaging microscopy (FLIM)
Fluorescence lifetime spectroscopy
Intravascular ultrasound
Marcu, L. (2010). Fluorescence lifetime in cardiovascular diagnostics. Journal of Biomedical Optics, 15(1), [011106]. https://doi.org/10.1117/1.3327279
Fluorescence lifetime in cardiovascular diagnostics. / Marcu, Laura.
In: Journal of Biomedical Optics, Vol. 15, No. 1, 011106, 2010.
Marcu, L 2010, 'Fluorescence lifetime in cardiovascular diagnostics', Journal of Biomedical Optics, vol. 15, no. 1, 011106. https://doi.org/10.1117/1.3327279
Marcu L. Fluorescence lifetime in cardiovascular diagnostics. Journal of Biomedical Optics. 2010;15(1). 011106. https://doi.org/10.1117/1.3327279
Marcu, Laura. / Fluorescence lifetime in cardiovascular diagnostics. In: Journal of Biomedical Optics. 2010 ; Vol. 15, No. 1.
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title = "Fluorescence lifetime in cardiovascular diagnostics",
abstract = "We review fluorescence lifetime techniques including timeresolved laser-induced fluorescence spectroscopy (TR-LIFS) and fluorescence lifetime imaging microscopy (FLIM) instrumentation and associated methodologies that allow for characterization and diagnosis of atherosclerotic plaques. Emphasis is placed on the translational research potential of TR-LIFS and FLIM and on determining whether intrinsic fluorescence signals can be used to provide useful contrast for the diagnosis of high-risk atherosclerotic plaque. Our results demonstrate that these techniques allow for the discrimination of important biochemical features involved in atherosclerotic plaque instability and rupture and show their potential for future intravascular applications.",
keywords = "Atherosclerotic plaques, Fluorescence lifetime imaging microscopy (FLIM), Fluorescence lifetime spectroscopy, Intravascular ultrasound",
author = "Laura Marcu",
journal = "Journal of Biomedical Optics",
T1 - Fluorescence lifetime in cardiovascular diagnostics
AU - Marcu, Laura
N2 - We review fluorescence lifetime techniques including timeresolved laser-induced fluorescence spectroscopy (TR-LIFS) and fluorescence lifetime imaging microscopy (FLIM) instrumentation and associated methodologies that allow for characterization and diagnosis of atherosclerotic plaques. Emphasis is placed on the translational research potential of TR-LIFS and FLIM and on determining whether intrinsic fluorescence signals can be used to provide useful contrast for the diagnosis of high-risk atherosclerotic plaque. Our results demonstrate that these techniques allow for the discrimination of important biochemical features involved in atherosclerotic plaque instability and rupture and show their potential for future intravascular applications.
AB - We review fluorescence lifetime techniques including timeresolved laser-induced fluorescence spectroscopy (TR-LIFS) and fluorescence lifetime imaging microscopy (FLIM) instrumentation and associated methodologies that allow for characterization and diagnosis of atherosclerotic plaques. Emphasis is placed on the translational research potential of TR-LIFS and FLIM and on determining whether intrinsic fluorescence signals can be used to provide useful contrast for the diagnosis of high-risk atherosclerotic plaque. Our results demonstrate that these techniques allow for the discrimination of important biochemical features involved in atherosclerotic plaque instability and rupture and show their potential for future intravascular applications.
KW - Atherosclerotic plaques
KW - Fluorescence lifetime imaging microscopy (FLIM)
KW - Fluorescence lifetime spectroscopy
KW - Intravascular ultrasound
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics