Antibodies to glycoconjugates in human motor neuron disease
Norman Latov, Arthur P. Hays, Robert K Yu, Hiroaki Ito, Florian P. Thomas
IgM monoclonal gammopathy has been reported in some patients with motor neuron disease. The monoclonal IgMs in several of the patients bind to the carbohydrate epitope Gal (β1-3) GalNAc, which is shared by gangliosides GM1 and GD1b and glycoproteins in the nervous system and crossreacted with Gal (β1-3) G1cNAc. They also immunostain spinal cord and gray matter and presynaptic terminals of motor neurons at the neuromuscular junction. The role and mechanisms of action of these antibodies in motor neuron disease is under investigation.
Neurochemical Pathology
Glycoconjugates
G(M1) Ganglioside
Neuromuscular Junction
Motor Neurons
Immunoglobulin M
galactosyll(1,3)-N-acetylgalactosamine
Motor neurons, degeneration of
and gangliosides
autoimmune mechanisms
glycolipids
Latov, N., Hays, A. P., Yu, R. K., Ito, H., & Thomas, F. P. (1988). Antibodies to glycoconjugates in human motor neuron disease. Neurochemical Pathology, 8(3), 181-187. https://doi.org/10.1007/BF03160145
Antibodies to glycoconjugates in human motor neuron disease. / Latov, Norman; Hays, Arthur P.; Yu, Robert K; Ito, Hiroaki; Thomas, Florian P.
In: Neurochemical Pathology, Vol. 8, No. 3, 01.06.1988, p. 181-187.
Latov, N, Hays, AP, Yu, RK, Ito, H & Thomas, FP 1988, 'Antibodies to glycoconjugates in human motor neuron disease', Neurochemical Pathology, vol. 8, no. 3, pp. 181-187. https://doi.org/10.1007/BF03160145
Latov N, Hays AP, Yu RK, Ito H, Thomas FP. Antibodies to glycoconjugates in human motor neuron disease. Neurochemical Pathology. 1988 Jun 1;8(3):181-187. https://doi.org/10.1007/BF03160145
Latov, Norman ; Hays, Arthur P. ; Yu, Robert K ; Ito, Hiroaki ; Thomas, Florian P. / Antibodies to glycoconjugates in human motor neuron disease. In: Neurochemical Pathology. 1988 ; Vol. 8, No. 3. pp. 181-187.
@article{d61fd2a571934815bad5707de031682e,
title = "Antibodies to glycoconjugates in human motor neuron disease",
abstract = "IgM monoclonal gammopathy has been reported in some patients with motor neuron disease. The monoclonal IgMs in several of the patients bind to the carbohydrate epitope Gal (β1-3) GalNAc, which is shared by gangliosides GM1 and GD1b and glycoproteins in the nervous system and crossreacted with Gal (β1-3) G1cNAc. They also immunostain spinal cord and gray matter and presynaptic terminals of motor neurons at the neuromuscular junction. The role and mechanisms of action of these antibodies in motor neuron disease is under investigation.",
keywords = "Motor neurons, degeneration of, and gangliosides, autoimmune mechanisms, glycolipids, monoclonal antibodies",
author = "Norman Latov and Hays, {Arthur P.} and Yu, {Robert K} and Hiroaki Ito and Thomas, {Florian P.}",
doi = "10.1007/BF03160145",
journal = "Journal of Molecular Neuroscience",
T1 - Antibodies to glycoconjugates in human motor neuron disease
AU - Latov, Norman
AU - Hays, Arthur P.
AU - Yu, Robert K
AU - Ito, Hiroaki
AU - Thomas, Florian P.
N2 - IgM monoclonal gammopathy has been reported in some patients with motor neuron disease. The monoclonal IgMs in several of the patients bind to the carbohydrate epitope Gal (β1-3) GalNAc, which is shared by gangliosides GM1 and GD1b and glycoproteins in the nervous system and crossreacted with Gal (β1-3) G1cNAc. They also immunostain spinal cord and gray matter and presynaptic terminals of motor neurons at the neuromuscular junction. The role and mechanisms of action of these antibodies in motor neuron disease is under investigation.
AB - IgM monoclonal gammopathy has been reported in some patients with motor neuron disease. The monoclonal IgMs in several of the patients bind to the carbohydrate epitope Gal (β1-3) GalNAc, which is shared by gangliosides GM1 and GD1b and glycoproteins in the nervous system and crossreacted with Gal (β1-3) G1cNAc. They also immunostain spinal cord and gray matter and presynaptic terminals of motor neurons at the neuromuscular junction. The role and mechanisms of action of these antibodies in motor neuron disease is under investigation.
KW - Motor neurons, degeneration of
KW - and gangliosides
KW - autoimmune mechanisms
KW - glycolipids
KW - monoclonal antibodies
U2 - 10.1007/BF03160145
DO - 10.1007/BF03160145
JO - Journal of Molecular Neuroscience
JF - Journal of Molecular Neuroscience
10.1007/BF03160145