Drug Delivery Disposition & Dynamics
Faculty of Pharmacy and Pharmaceutical Sciences
18 Comment / Debate
Influence of storage relative humidity on the dispersion of salmeterol xinafoate powders for inhalation
Das, S. C., Larson, I. C., Young, P. M. & Stewart, P. J., 2009, In : Journal of Pharmaceutical Sciences. 98, p. 1015 - 1027 12 p.
Influence of the polydispersity of the added fine lactose on the dispersion of salmeterol xinafoate from mixtures for inhalation
Adi, H., Larson, I. C. & Stewart, P. J., 2009, In : European Journal of Pharmaceutical Sciences. 36, 2-3, p. 265 - 274 10 p.
Intestinal lymphatic transport enhances the post-prandial oral bioavailability of a novel cannabinoid receptor agonist via avoidance of first-pass metabolism
Trevaskis, N., Shackleford, D., Charman, W. N., Edwards, G. A., Gardin, A., Appel-Dingemanse, S., Kretz, O., Galli, B. & Porter, C. J., 2009, In : Pharmaceutical Research. 26, 6, p. 1486 - 1495 10 p.
Liquid crystalline coated drug particles as a potential route to long acting intravitreal steroids
Tilley, A. J., Morton, D. A. V., Hanley, T. & Boyd, B. J., 2009, In : Current Drug Delivery. 6, 4, p. 322 - 331 10 p.
Liquid crystalline systems of phytantriol and glyceryl monooleate containing a hydrophilic protein: characterisation, swelling and release kinetics
Rizwan, S. B., Hanley, T., Boyd, B. J., Rades, T. & Hook, S., 2009, In : Journal of Pharmaceutical Sciences. 98, 11, p. 4191 - 4204 14 p.
Lymphatic transport of methylnortestosterone undecanoate (MU) and the bioavailability of methylnortestosterone are highly sensitive to the mass of coadministered lipid after oral administration of MU
White, K. L., Nguyen, G., Charman, W. N., Edwards, G. A., Faassen, W. A. F. & Porter, C. J., 2009, In : Journal of Pharmacology and Experimental Therapeutics. 331, 2, p. 700 - 709 10 p.
Miniature inhalation therapy platform using surface acoustic wave microfluidic atomization
Qi, A., Friend, J., Yeo, L. Y-M., Morton, D. A. V., McIntosh, M. P. & Spiccia, L., 2009, In : Lab on a Chip. 9, p. 2184 - 2193 10 p.
Nanostructure of liquid crystalline matrix determines in vitro sustained release and in vivo oral absorption kinetics for hydrophilic model drugs
Lee, K. W-Y., Nguyen, T-H., Hanley, T. & Boyd, B. J., 2009, In : International Journal of Pharmaceutics. 365, 1-2, p. 190 - 199 10 p.
Nonlamellar liquid crystalline nanostructured particles: advances in materials and structure determination
Boyd, B. J., Dong, Y-D. & Rades, T., 2009, In : Journal of Liposome Research. 19, 1, p. 12 - 28 17 p.
Oral bioavailability assessment and intestinal lymphatic transport of org 45697 and org 46035, two highly lipophilic novel immunomodulator analogues
Caliph, S. M., Faassen, W. A., Vogel, G. M. & Porter, C. J., 2009, In : Current Drug Delivery. 6, 4, p. 359 - 366 8 p.
Overcoming biological barriers to in vivo efficacy of antisense oligonucleotides.
White, P. J., Anastasopoulos, F., Pouton, C. W. & Boyd, B. J., 2009, In : Expert Reviews in Molecular Medicine. 11, e10, p. 1 - 19 19 p.
Partly-PEGylated poly-L-lysine dendrimers have reduced plasma stability and circulation times compared with fully PEGylated dendrimers
Kaminskas, L. M., Wu, Z., Barlow, N., Krippner, G. Y., Boyd, B. J. & Porter, C. J. H., 2009, In : Journal of Pharmaceutical Sciences. 98, 10, p. 3871 - 3875 5 p.
PEGylation of polylysine dendrimers improves absorption and lymphatic targeting following SC administration in rats
Kaminskas, L. M., Kota, J., McLeod, V. M., Kelly, B. D., Karellas, P. & Porter, C. J., 2009, In : Journal of Controlled Release. 140, 2, p. 108 - 116 9 p.
Pharmacokinetics and tumor disposition of PEGylated, methotrexate conjugated poly-L-lysine dendrimers
Kaminskas, L. M., Kelly, B. D., McLeod, V. M., Boyd, B. J., Krippner, G. Y., Williams, E. & Porter, C. J., 2009, In : Molecular Pharmaceutics. 6, 4, p. 1190 - 1204 15 p.
Phenylaminopyrimidines as inhibitors of Janus kinases (JAKs)
Burns, C., Bourke, D. G., Andrau, L., Bu, X., Charman, S. A., Donohue, A. C., Fantino, E., Farrugia, M., Feutrill, J. T., Joffe, M., Kling, R. M., Kurek, M., Nero, T. L., Nguyen, T., Palmer, J. T., Phillips, I. D., Shackleford, D., Sikanyika, H., Styles, M., Su, S. & 3 others, Treutlein, H. R., Zeng, J. & Wilks, A. F., 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 20, p. 5887 - 5892 6 p.
Positron annihilation lifetime spectroscopy (PALS) as a characterization technique for nanostructured self-assembled amphiphile systems
Dong, A., Pascual-Izzara, C., Pas, S. J., Hill, A., Boyd, B. J. & Drummond, C. J., 2009, In : Journal of Physical Chemistry B. 113, 1, p. 84 - 91 8 p.
Probing the fibrate binding specificity of rat liver fatty acid binding protein
Chuang, S., Velkov, T., Horne, H. J., Wielens, J., Chalmers, D. K., Porter, C. J. & Scanlon, M., 2009, In : Journal of Medicinal Chemistry. 52, 17, p. 5344 - 5355 12 p.
S-glycosyl primary sulfonamides - A new structural class for selective inhibition of cancer-associated carbonic anhydrases
Lopez, M., Paul, B., Hofmann, A., Morizzi, J., Wu, Q. K., Charman, S. A., Innocenti, A., Vullo, D., Supuran, C. T. & Poulsen, S. A., 22 Oct 2009, In : Journal of Medicinal Chemistry. 52, 20, p. 6421-6432 12 p.
Short-term changes in drug agglomeration within interactive mixtures following blending
Andreou, J., Stewart, P. & Morton, D., 2009, In : International Journal of Pharmaceutics. 372, 1-2, p. 1 - 11 11 p.
Simultaneous determination of OZ277, a synthetic 1,2,4-trioxolane antimalarial, and its polar metabolites in rat plasma using hydrophilic interaction chromatography
Bhamidipati, R. K., Morizzi, J., Chiu, F. C. K., Shackleford, D. & Charman, S. A., 2009, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 877, 27, p. 2989 - 2995 7 p.
Spiroadamantyl 1,2,4-trioxolane, 1,2,4-trioxane, and 1,2,4-trioxepane pairs: Relationship between peroxide bond iron(II) reactivity, heme alkylation efficiency, and antimalarial activity
Wang, X., Creek, D. J., Schiaffo, C. E., Dong, Y., Chollet, J., Scheurer, C., Wittlin, S., Charman, S. A., Dussault, P. H., Wood, J. K. & Vennerstrom, J., 2009, In : Bioorganic and Medicinal Chemistry Letters. 19, 16, p. 4542 - 4545 4 p.
Stability of peroxide antimalarials in the presence of human hemoglobin
Creek, D. J., Ryan, E., Charman, W. N., Chiu, F. C. K., Prankerd, R., Vennerstrom, J. & Charman, S. A., 2009, In : Antimicrobial Agents and Chemotherapy. 53, 8, p. 3496 - 3500 5 p.
Stimuli responsive liquid crystals provide 'on-demand' drug delivery in vitro and in vivo
Fong, W. K., Hanley, T. L. & Boyd, B. J., 2009, In : Journal of Controlled Release. 135, 3, p. 218 - 226 9 p.
Surface energy changes and their relationship with the dispersibility of salmeterol xinafoate powders for inhalation after storage at high RH
Das, S. C., Larson, I. C., Young, P. M. & Stewart, P. J., 2009, In : European Journal of Pharmaceutical Sciences. 38, 4, p. 347 - 354 8 p.
The role of force control agents in high-dose dry powder inhaler formulations
Begat, P., Morton, D. A. V., Shur, J., Kippax, P., Staniforth, J. N. & Price, R., 2009, In : Journal of Pharmaceutical Sciences. 98, 8, p. 2770 - 2783 14 p.
Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins
Rizwan, S., Boyd, B., Rades, T. & Hook, S., 2010, In : Expert Opinion on Drug Delivery. 7, 10, p. 1133 - 1144 12 p.
Brain uptake of diazepam and phenytoin in a genetic animal model of absence epilepsy
Nicolazzo, J., Steuten, J. A., Charman, S. A., Taylor, N., Davies, P. & Petrou, S., 2010, In : Clinical and Experimental Pharmacology and Physiology. 37, p. 647 - 649 3 p.
Chitosan nanoparticles enhance the intestinal absorption of the green tea catechins (+)-catechin and (-)-epigallocatechin gallate
Dube, A., Nicolazzo, J. & Larson, I. C., 2010, In : European Journal of Pharmaceutical Sciences. 41, p. 219 - 225 7 p.
Discovery of novel benzo[ a ]phenoxazine SSJ-183 as a drug candidate for malaria
Ge, J-F., Arai, C., Yang, M., Bakar, A., Lu, J., Ismail, N. S. M., Wittlin, S., Kaiser, M., Brun, R., Charman, S. A., Nguyen, T., Morizzi, J., Itoh, I. & Ihara, M., 2010, In : ACS Medicinal Chemistry Letters. 1, 7, p. 360 - 364 5 p.
Diverse ordered 3D nanostructured amphiphile self-assembly materials found in protic ionic liquids
Mulet, X., Kennedy, D., Greaves, T., Waddington, L., Hawley, A., Kirby, N. & Drummond, C., 2010, In : Journal of Physical Chemistry Letters. 1, 18, p. 2651 - 2654 4 p.
Effective use of reducing agents and nanoparticle encapsulation in stabilizing catechins in alkaline solution
Dube, A., Ng, K., Nicolazzo, J. & Larson, I. C., 2010, In : Food Chemistry. 122, p. 662 - 667 6 p.
Effect of electroacupuncture on the third lumbar transverse process syndrome: A randomized controlled trial
Miao, E. & Miao, M., 2010, In : Medical Acupuncture. 22, 4, p. 249 - 255 7 p.
Efficacy of antimicrobial polymer coatings in an animal model of bacterial infection associated with foreign body implants
Hart, E., Azzopardi, K., Taing, H., Graichen, F., Jeffery, J., Mayadunne, R., Wickramaratna, M., OShea, M., Nijagal, B., Watkinson, R., OLeary, S., Finnin, B., Tait, R. & Robins-Browne, R., 2010, In : Journal of Antimicrobial Chemotherapy. 65, 5, p. 974 - 980 7 p.
High throughput preparation and characterisation of amphiphilic nanostructured nanoparticulate drug delivery vehicles
Mulet, X., Kennedy, D., Conn, C., Hawley, A. & Drummond, C., 2010, In : International Journal of Pharmaceutics. 395, 1-2, p. 290 - 297 8 p.
Impact of chlorpromazine self-association on its apparent binding constants with cyclodextrins: Effect of SBE7-beta-CD on the disposition of chlorpromazine in the rat
McIntosh, M. P., Leong, N., Katneni, K., Morizzi, J., Shackleford, D. M. & Prankerd, R. J., 2010, In : Journal of Pharmaceutical Sciences. 99, 7, p. 2999 - 3008 10 p.
Improving aerosolization of drug powders by reducing powder intrinsic cohesion via a mechanical dry coating approach
Zhou, Q., Qu, L., Larson, I. C., Stewart, P. J. & Morton, D. A. V., 2010, In : International Journal of Pharmaceutics. 394, 1-Feb, p. 50 - 59 10 p.
Improving powder flow properties of a cohesive lactose monohydrate powder by intensive mechanical dry coating
Zhou, Q., Armstrong, B., Larson, I. C., Stewart, P. J. & Morton, D. A. V., 2010, In : Journal of Pharmaceutical Sciences. 99, 2, p. 969 - 981 13 p.
Inhibiting heat-shock protein 90 reverses sensory hypoalgesia in biabetic mice
Urban, M., Li, C., Yu, C., Lu, Y., Krise, J., McIntosh, M. P., Rajewski, R. A., Blagg, B. & Dobrowsky, R. T., 2010, In : ASN Neuro. 2, 4, p. 189 - 199 11 p.
Ligand-enhanced expression and in-cell assay of human peroxisome proliferator-activated receptor alpha ligand binding domain
Velkov, T., Rimmer, K. & Headey, S., 2010, In : Protein Expression and Purification. 70, 2, p. 260 - 269 10 p.
Magnesium stearate increases salbutamol sulphate dispersion: what is the mechanism?
Tay, T., Das, S. C. & Stewart, P. J., 2010, In : International Journal of Pharmaceutics. 383, p. 62 - 69 8 p.
Monodisperse nonionic phytanyl ethylene oxide surfactants: High throughput lyotropic liquid crystalline phase determination and the formation of liposomes, hexosomes and cubosomes
Fong, C., Weerawardena, A., Sagnella, S., Mulet, X., Waddington, L., Krodkiewska, I. & Drummond, C., 2010, In : Soft Matter. 6, 19, p. 4727 - 4741 15 p.
Nanostructured nonionic thymidine nucleolipid self-assembly materials
Mulet, X., Kaasgaard, T., Conn, C., Waddington, L., Kennedy, D., Weerawardena, A. & Drummond, C., 2010, In : Langmuir: the ACS journal of surfaces and colloids. 26, 23, p. 18415 - 18423 9 p.
Nonequilibrium effects in self-assembled mesophase materials: unexpected supercooling effects for cubosomes and hexosomes
Dong, C. Y-D., Tilley, A. J., Larson, I. C., Lawrence, J., Amenitsch, H., Rappolt, M., Hanley, T. L. & Boyd, B. J., 2010, In : Langmuir: the ACS journal of surfaces and colloids. 26, 11, p. 9000 - 9010 11 p.
Phytantriol and glyceryl monooleate cubic liquid crystalline phases as sustained-release oral drug delivery systems for poorly water soluble drugs I. Phase behaviour in physiologically-relevant media
Nguyen, T-H., Hanley, T., Porter, C., Larson, I. & Boyd, B., 2010, In : Journal of Pharmacy and Pharmacology. 62, p. 844 - 855 12 p.
Phytantriol and glyceryl monooleate cubic liquid crystalline phases as sustained-release oral drug delivery systems for poorly water-soluble drugs II. In-vivo evaluation
Nguyen, T-H., Hanley, T., Porter, C., Larson, I. & Boyd, B., 2010, In : Journal of Pharmacy and Pharmacology. 62, 7, p. 856 - 865 10 p.
Plasmonic nanorods provide reversible control over nanostructure of self-assembled drug delivery materials
Fong, W. K., Hanley, T. L., Thierry, B., Kirby, N. & Boyd, B. J., 2010, In : Langmuir: the ACS journal of surfaces and colloids. 26, 9, p. 6136 - 6139 4 p.
Preclinical comparison of intravenous melphalan pharmacokinetics administered in formulations containing either (SBE)7m-beta-cyclodextrin or a co-solvent system
Koltun, M., Morizzi, J., Katneni, K., Charman, S. A., Shackleford, D. & McIntosh, M. P., 2010, In : Biopharmaceutics and Drug Disposition. 31, 8-9, p. 450 - 454 5 p.
Self-assembly behavior of colistin and its prodrug colistin methanesulfonate: implications for solution stability and solubilization
Wallace, S. J., Li, J., Nation, R. L., Prankerd, R. J., Velkov, T. & Boyd, B. J., 2010, In : Journal of Physical Chemistry B. 114, p. 4836 - 4840 5 p.
Silica nanoparticles to control the lipase-mediated digestion of lipid-based oral delivery systems
Tan, A., Simovic, S., Davey, A., Rades, T., Boyd, B. J. & Prestidge, C. A., 2010, In : Molecular Pharmaceutics. 7, 2, p. 522 - 532 11 p.
Sulfonamide linked neoglycoconjugates-A new class of inhibitors for cancer-associated carbonic anhydrases
Lopez, M., Bornaghi, L. F., Innocenti, A., Vullo, D., Charman, S. A., Supuran, C. T. & Poulsen, S-A., 2010, In : Journal of Medicinal Chemistry. 53, p. 2913 - 2926 14 p.