Mononuclear phagocytes in the pathogenesis of neurodegenerative diseases
Irena Kadiu, Jason G. Glanzer, Jonathan Kipnis, Howard Eliot Gendelman, Mark P. Thomas
Pharmacology & Experimental Neuroscience (PEN)
Pathology & Microbiology
Fred & Pamela Buffett Cancer Center
Brain mononuclear phagocytes (MP, bone marrow monocyte-derived macrophages, perivascular macrophages, and microglia) function to protect the nervous system by acting as debris scavengers, killers of microbial pathogens, and regulators of immune responses. MP are activated by a variety of environmental cues and such inflammatory responses elicit cell injury and death in the nervous system. MP immunoregulatory responses include secretion of neurotoxic factors, mobilization of adaptive immunity, and cell chemotaxis. This incites tissue remodelling and blood-brain barrier dysfunction. As disease progresses, MP secretions engage neighboring cells in a vicious cycle of autocrine and paracrine amplification of inflammation leading to tissue injury and ultimately destruction. Such pathogenic processes tilt the balance between the relative production of neurotrophic and neurotoxic factors, leading to disease progression. The ultimate effects that brain MP play in disease revolve "principally" around their roles in neurodegeneration. Importantly, common functions of brain MP in neuroimmunity link highly divergent diseases (for example, human immunodeficiency virus type-one associated dementia, Alzheimer's disease and Parkinson's disease). Research from our own laboratories and those of others seek to harness MP inflammatory processes with the intent of developing therapeutic interventions that block neurodegenerative processes and improve the quality of life in affected people.
Neurotoxicity Research
Phagocytes
HIV-1
HIV-1 associated dementia
Mononuclear Phagocytes
Neuroimmunity
Neurotoxic factors
Kadiu, I., Glanzer, J. G., Kipnis, J., Gendelman, H. E., & Thomas, M. P. (2005). Mononuclear phagocytes in the pathogenesis of neurodegenerative diseases. Neurotoxicity Research, 8(1-2), 25-50. https://doi.org/10.1007/BF03033818
Mononuclear phagocytes in the pathogenesis of neurodegenerative diseases. / Kadiu, Irena; Glanzer, Jason G.; Kipnis, Jonathan; Gendelman, Howard Eliot; Thomas, Mark P.
In: Neurotoxicity Research, Vol. 8, No. 1-2, 01.12.2005, p. 25-50.
Kadiu, I, Glanzer, JG, Kipnis, J, Gendelman, HE & Thomas, MP 2005, 'Mononuclear phagocytes in the pathogenesis of neurodegenerative diseases', Neurotoxicity Research, vol. 8, no. 1-2, pp. 25-50. https://doi.org/10.1007/BF03033818
Kadiu I, Glanzer JG, Kipnis J, Gendelman HE, Thomas MP. Mononuclear phagocytes in the pathogenesis of neurodegenerative diseases. Neurotoxicity Research. 2005 Dec 1;8(1-2):25-50. https://doi.org/10.1007/BF03033818
Kadiu, Irena ; Glanzer, Jason G. ; Kipnis, Jonathan ; Gendelman, Howard Eliot ; Thomas, Mark P. / Mononuclear phagocytes in the pathogenesis of neurodegenerative diseases. In: Neurotoxicity Research. 2005 ; Vol. 8, No. 1-2. pp. 25-50.
@article{71728308939f4076aaf67d11feb10fe2,
title = "Mononuclear phagocytes in the pathogenesis of neurodegenerative diseases",
abstract = "Brain mononuclear phagocytes (MP, bone marrow monocyte-derived macrophages, perivascular macrophages, and microglia) function to protect the nervous system by acting as debris scavengers, killers of microbial pathogens, and regulators of immune responses. MP are activated by a variety of environmental cues and such inflammatory responses elicit cell injury and death in the nervous system. MP immunoregulatory responses include secretion of neurotoxic factors, mobilization of adaptive immunity, and cell chemotaxis. This incites tissue remodelling and blood-brain barrier dysfunction. As disease progresses, MP secretions engage neighboring cells in a vicious cycle of autocrine and paracrine amplification of inflammation leading to tissue injury and ultimately destruction. Such pathogenic processes tilt the balance between the relative production of neurotrophic and neurotoxic factors, leading to disease progression. The ultimate effects that brain MP play in disease revolve {"}principally{"} around their roles in neurodegeneration. Importantly, common functions of brain MP in neuroimmunity link highly divergent diseases (for example, human immunodeficiency virus type-one associated dementia, Alzheimer's disease and Parkinson's disease). Research from our own laboratories and those of others seek to harness MP inflammatory processes with the intent of developing therapeutic interventions that block neurodegenerative processes and improve the quality of life in affected people.",
keywords = "Alzheimer disease, HIV-1, HIV-1 associated dementia, Inflammation, Mononuclear Phagocytes, Neurodegeneration, Neuroimmunity, Neurotoxic factors, Parkinson's disease",
author = "Irena Kadiu and Glanzer, {Jason G.} and Jonathan Kipnis and Gendelman, {Howard Eliot} and Thomas, {Mark P.}",
journal = "Neurotoxicity Research",
T1 - Mononuclear phagocytes in the pathogenesis of neurodegenerative diseases
AU - Kadiu, Irena
AU - Glanzer, Jason G.
AU - Kipnis, Jonathan
AU - Gendelman, Howard Eliot
AU - Thomas, Mark P.
N2 - Brain mononuclear phagocytes (MP, bone marrow monocyte-derived macrophages, perivascular macrophages, and microglia) function to protect the nervous system by acting as debris scavengers, killers of microbial pathogens, and regulators of immune responses. MP are activated by a variety of environmental cues and such inflammatory responses elicit cell injury and death in the nervous system. MP immunoregulatory responses include secretion of neurotoxic factors, mobilization of adaptive immunity, and cell chemotaxis. This incites tissue remodelling and blood-brain barrier dysfunction. As disease progresses, MP secretions engage neighboring cells in a vicious cycle of autocrine and paracrine amplification of inflammation leading to tissue injury and ultimately destruction. Such pathogenic processes tilt the balance between the relative production of neurotrophic and neurotoxic factors, leading to disease progression. The ultimate effects that brain MP play in disease revolve "principally" around their roles in neurodegeneration. Importantly, common functions of brain MP in neuroimmunity link highly divergent diseases (for example, human immunodeficiency virus type-one associated dementia, Alzheimer's disease and Parkinson's disease). Research from our own laboratories and those of others seek to harness MP inflammatory processes with the intent of developing therapeutic interventions that block neurodegenerative processes and improve the quality of life in affected people.
AB - Brain mononuclear phagocytes (MP, bone marrow monocyte-derived macrophages, perivascular macrophages, and microglia) function to protect the nervous system by acting as debris scavengers, killers of microbial pathogens, and regulators of immune responses. MP are activated by a variety of environmental cues and such inflammatory responses elicit cell injury and death in the nervous system. MP immunoregulatory responses include secretion of neurotoxic factors, mobilization of adaptive immunity, and cell chemotaxis. This incites tissue remodelling and blood-brain barrier dysfunction. As disease progresses, MP secretions engage neighboring cells in a vicious cycle of autocrine and paracrine amplification of inflammation leading to tissue injury and ultimately destruction. Such pathogenic processes tilt the balance between the relative production of neurotrophic and neurotoxic factors, leading to disease progression. The ultimate effects that brain MP play in disease revolve "principally" around their roles in neurodegeneration. Importantly, common functions of brain MP in neuroimmunity link highly divergent diseases (for example, human immunodeficiency virus type-one associated dementia, Alzheimer's disease and Parkinson's disease). Research from our own laboratories and those of others seek to harness MP inflammatory processes with the intent of developing therapeutic interventions that block neurodegenerative processes and improve the quality of life in affected people.
KW - Alzheimer disease
KW - HIV-1
KW - HIV-1 associated dementia
KW - Inflammation
KW - Mononuclear Phagocytes
KW - Neurodegeneration
KW - Neuroimmunity
KW - Neurotoxic factors
KW - Parkinson's disease
JO - Neurotoxicity Research
JF - Neurotoxicity Research