News Release 17-Sep-2018
Characterizing pig hippocampus could improve translational neuroscience
Study establishes pig as promising preclinical research model for traumatic brain injury, epilepsy
Society for Neuroscience
image: A comparison of the laminar structure in the pig and the rat hippocampus revealed conservation of the layered structure, with a remarkably small increase in the overall layer width given that the pig brain is 50X larger in mass. Recordings using a laminar silicone probe with 32 electrode channels half the width of a human hair revealed laminar electrophysiology and single neuron activity with features of both rodent and primate hippocampus (electrode photo courtesy of NeuroNexus Technologies). view more
Credit: Ulyanova et al., <i>eNeuro</i> (2018)
Researchers have taken further steps toward developing a superior animal model of neurological conditions such as traumatic brain injury and epilepsy, according to a study of miniature pigs published in eNeuro. The results establish the pig as a promising preclinical research model for hippocampal-dependent human memory disorders.
The structure and function of hippocampus has been extensively studied in rodents and non-human primates, animals that together enable experimental manipulation and a way to address species differences. Domesticated miniature pigs -- developed as laboratory animals for their smaller size and comparative anatomy -- have recently emerged as a middle ground model with potential to bridge the gap between rodents and non-human primates in a single, behaviorally complex organism.
Building on initial neuroimaging studies of the pig brain, John Wolf and colleagues developed new electrophysiology techniques to probe the structure and record neural activity of the Yucatan miniature pig hippocampus. With this approach the researchers confirmed features of the pig hippocampus comparable to those of rodents and non-human primates, allowing for future investigations of translational disease models involving this important brain structure.
Article: Electrophysiological Signature Reveals Laminar Structure of the Porcine Hippocampus*
DOI: https://doi.org/10.1523/ENEURO.0102-18.2018 Corresponding author: John Wolf (University of Pennsylvania, Philadelphia, USA), wolfjo@pennmedicine.upenn.edu
*A preprint of this manuscript has been posted on bioRxiv.
About eNeuro
eNeuro, the Society for Neuroscience's open-access journal launched in 2014, publishes rigorous neuroscience research with double-blind peer review that masks the identity of both the authors and reviewers, minimizing the potential for implicit biases. eNeuro is distinguished by a broader scope and balanced perspective achieved by publishing negative results, failure to replicate or replication studies. New research, computational neuroscience, theories and methods are also published.
About The Society for Neuroscience
The Society for Neuroscience is the world's largest organization of scientists and physicians devoted to understanding the brain and nervous system. The nonprofit organization, founded in 1969, now has nearly 37,000 members in more than 90 countries and over 130 chapters worldwide.
10.1523/ENEURO.0102-18.2018
David Barnstone
dbarnstone@sfn.org
CURE Foundation, , NIH/National Institutes of Neurological Disorders and Stroke, United States Department of Defense,
/Life sciences/Organismal biology/Animals/Vertebrates/Mammals/Pigs
/Life sciences/Organismal biology/Anatomy/Nervous system/Central nervous system/Brain/Limbic system/Hippocampus
/Life sciences/Neuroscience/Clinical neuroscience/Neurology/Neurological disorders/Epilepsy