Perturbations in Lineage Specification of Granulosa and Theca Cells May Alter Corpus Luteum Formation and Function
Mohamed A. Abedel-Majed, Sarah M. Romereim, John S. Davis, Andrea S. Cupp
VA Nebraska-Western Iowa Health Care System
Center for Heart and Vascular Research
Anovulation is a major cause of infertility, and it is the major leading reproductive disorder in mammalian females. Without ovulation, an oocyte is not released from the ovarian follicle to be fertilized and a corpus luteum is not formed. The corpus luteum formed from the luteinized somatic follicular cells following ovulation, vasculature cells, and immune cells is critical for progesterone production and maintenance of pregnancy. Follicular theca cells differentiate into small luteal cells (SLCs) that produce progesterone in response to luteinizing hormone (LH), and granulosa cells luteinize to become large luteal cells (LLCs) that have a high rate of basal production of progesterone. The formation and function of the corpus luteum rely on the appropriate proliferation and differentiation of both granulosa and theca cells. If any aspect of granulosa or theca cell luteinization is perturbed, then the resulting luteal cell populations (SLC, LLC, vascular, and immune cells) may be reduced and compromise progesterone production. Thus, many factors that affect the differentiation/lineage of the somatic cells and their gene expression profiles can alter the ability of a corpus luteum to produce the progesterone critical for pregnancy. Our laboratory has identified genes that are enriched in somatic follicular cells and luteal cells through gene expression microarray. This work was the first to compare the gene expression profiles of the four somatic cell types involved in the follicle-to-luteal transition and to support previous immunofluorescence data indicating theca cells differentiate into SLCs while granulosa cells become LLCs. Using these data and incorporating knowledge about the ways in which luteinization can go awry, we can extrapolate the impact that alterations in the theca and granulosa cell gene expression profiles and lineages could have on the formation and function of the corpus luteum. While interactions with other cell types such as vascular and immune cells are critical for appropriate corpus luteum function, we are restricting this review to focus on granulosa, theca, and luteal cells and how perturbations such as androgen excess and inflammation may affect their function and fertility.
Frontiers in Endocrinology
https://doi.org/10.3389/fendo.2019.00832
androgen
corpus luteum
granulosa cell
theca cell
10.3389/fendo.2019.00832
Fingerprint Dive into the research topics of 'Perturbations in Lineage Specification of Granulosa and Theca Cells May Alter Corpus Luteum Formation and Function'. Together they form a unique fingerprint.
Theca Cells Medicine & Life Sciences
Luteal Cells Medicine & Life Sciences
Granulosa Cells Medicine & Life Sciences
Corpus Luteum Medicine & Life Sciences
Progesterone Medicine & Life Sciences
Luteinization Medicine & Life Sciences
Ovulation Medicine & Life Sciences
Abedel-Majed, M. A., Romereim, S. M., Davis, J. S., & Cupp, A. S. (2019). Perturbations in Lineage Specification of Granulosa and Theca Cells May Alter Corpus Luteum Formation and Function. Frontiers in Endocrinology, 10, [832]. https://doi.org/10.3389/fendo.2019.00832
Perturbations in Lineage Specification of Granulosa and Theca Cells May Alter Corpus Luteum Formation and Function. / Abedel-Majed, Mohamed A.; Romereim, Sarah M.; Davis, John S.; Cupp, Andrea S.
In: Frontiers in Endocrinology, Vol. 10, 832, 29.11.2019.
Abedel-Majed, MA, Romereim, SM, Davis, JS & Cupp, AS 2019, 'Perturbations in Lineage Specification of Granulosa and Theca Cells May Alter Corpus Luteum Formation and Function', Frontiers in Endocrinology, vol. 10, 832. https://doi.org/10.3389/fendo.2019.00832
Abedel-Majed MA, Romereim SM, Davis JS, Cupp AS. Perturbations in Lineage Specification of Granulosa and Theca Cells May Alter Corpus Luteum Formation and Function. Frontiers in Endocrinology. 2019 Nov 29;10. 832. https://doi.org/10.3389/fendo.2019.00832
Abedel-Majed, Mohamed A. ; Romereim, Sarah M. ; Davis, John S. ; Cupp, Andrea S. / Perturbations in Lineage Specification of Granulosa and Theca Cells May Alter Corpus Luteum Formation and Function. In: Frontiers in Endocrinology. 2019 ; Vol. 10.
@article{bc8b5f5538864f7f872c60edb5b3c073,
title = "Perturbations in Lineage Specification of Granulosa and Theca Cells May Alter Corpus Luteum Formation and Function",
abstract = "Anovulation is a major cause of infertility, and it is the major leading reproductive disorder in mammalian females. Without ovulation, an oocyte is not released from the ovarian follicle to be fertilized and a corpus luteum is not formed. The corpus luteum formed from the luteinized somatic follicular cells following ovulation, vasculature cells, and immune cells is critical for progesterone production and maintenance of pregnancy. Follicular theca cells differentiate into small luteal cells (SLCs) that produce progesterone in response to luteinizing hormone (LH), and granulosa cells luteinize to become large luteal cells (LLCs) that have a high rate of basal production of progesterone. The formation and function of the corpus luteum rely on the appropriate proliferation and differentiation of both granulosa and theca cells. If any aspect of granulosa or theca cell luteinization is perturbed, then the resulting luteal cell populations (SLC, LLC, vascular, and immune cells) may be reduced and compromise progesterone production. Thus, many factors that affect the differentiation/lineage of the somatic cells and their gene expression profiles can alter the ability of a corpus luteum to produce the progesterone critical for pregnancy. Our laboratory has identified genes that are enriched in somatic follicular cells and luteal cells through gene expression microarray. This work was the first to compare the gene expression profiles of the four somatic cell types involved in the follicle-to-luteal transition and to support previous immunofluorescence data indicating theca cells differentiate into SLCs while granulosa cells become LLCs. Using these data and incorporating knowledge about the ways in which luteinization can go awry, we can extrapolate the impact that alterations in the theca and granulosa cell gene expression profiles and lineages could have on the formation and function of the corpus luteum. While interactions with other cell types such as vascular and immune cells are critical for appropriate corpus luteum function, we are restricting this review to focus on granulosa, theca, and luteal cells and how perturbations such as androgen excess and inflammation may affect their function and fertility.",
keywords = "PCOS, androgen, corpus luteum, differentiation, follicle, granulosa cell, infertility, theca cell",
author = "Abedel-Majed, {Mohamed A.} and Romereim, {Sarah M.} and Davis, {John S.} and Cupp, {Andrea S.}",
note = "Funding Information: This research was supported by National Institute of Food and Agriculture 2013-67015-20965 and 2017-67015-26450 to AC and JD, NIH HD092263 and HD087402 to AC and JD, University of Nebraska Food for Health Competitive Grants to AC and JD, United States Department of Agriculture Hatch grant NEB26-202/W3112 Accession #1011127 to AC, Hatch– NEB ANHL Accession #1002234 to AC, National Institute of Food and Agriculture postdoctoral fellowship 2016-67012-24697 to SR, and funds from the VA Research and Development Service, and Olson Center for Women{\textquoteright}s Health to JD.",
doi = "10.3389/fendo.2019.00832",
journal = "Frontiers in Endocrinology",
publisher = "Frontiers Media S. A.",
T1 - Perturbations in Lineage Specification of Granulosa and Theca Cells May Alter Corpus Luteum Formation and Function
AU - Abedel-Majed, Mohamed A.
AU - Romereim, Sarah M.
AU - Davis, John S.
AU - Cupp, Andrea S.
N1 - Funding Information: This research was supported by National Institute of Food and Agriculture 2013-67015-20965 and 2017-67015-26450 to AC and JD, NIH HD092263 and HD087402 to AC and JD, University of Nebraska Food for Health Competitive Grants to AC and JD, United States Department of Agriculture Hatch grant NEB26-202/W3112 Accession #1011127 to AC, Hatch– NEB ANHL Accession #1002234 to AC, National Institute of Food and Agriculture postdoctoral fellowship 2016-67012-24697 to SR, and funds from the VA Research and Development Service, and Olson Center for Women's Health to JD.
N2 - Anovulation is a major cause of infertility, and it is the major leading reproductive disorder in mammalian females. Without ovulation, an oocyte is not released from the ovarian follicle to be fertilized and a corpus luteum is not formed. The corpus luteum formed from the luteinized somatic follicular cells following ovulation, vasculature cells, and immune cells is critical for progesterone production and maintenance of pregnancy. Follicular theca cells differentiate into small luteal cells (SLCs) that produce progesterone in response to luteinizing hormone (LH), and granulosa cells luteinize to become large luteal cells (LLCs) that have a high rate of basal production of progesterone. The formation and function of the corpus luteum rely on the appropriate proliferation and differentiation of both granulosa and theca cells. If any aspect of granulosa or theca cell luteinization is perturbed, then the resulting luteal cell populations (SLC, LLC, vascular, and immune cells) may be reduced and compromise progesterone production. Thus, many factors that affect the differentiation/lineage of the somatic cells and their gene expression profiles can alter the ability of a corpus luteum to produce the progesterone critical for pregnancy. Our laboratory has identified genes that are enriched in somatic follicular cells and luteal cells through gene expression microarray. This work was the first to compare the gene expression profiles of the four somatic cell types involved in the follicle-to-luteal transition and to support previous immunofluorescence data indicating theca cells differentiate into SLCs while granulosa cells become LLCs. Using these data and incorporating knowledge about the ways in which luteinization can go awry, we can extrapolate the impact that alterations in the theca and granulosa cell gene expression profiles and lineages could have on the formation and function of the corpus luteum. While interactions with other cell types such as vascular and immune cells are critical for appropriate corpus luteum function, we are restricting this review to focus on granulosa, theca, and luteal cells and how perturbations such as androgen excess and inflammation may affect their function and fertility.
AB - Anovulation is a major cause of infertility, and it is the major leading reproductive disorder in mammalian females. Without ovulation, an oocyte is not released from the ovarian follicle to be fertilized and a corpus luteum is not formed. The corpus luteum formed from the luteinized somatic follicular cells following ovulation, vasculature cells, and immune cells is critical for progesterone production and maintenance of pregnancy. Follicular theca cells differentiate into small luteal cells (SLCs) that produce progesterone in response to luteinizing hormone (LH), and granulosa cells luteinize to become large luteal cells (LLCs) that have a high rate of basal production of progesterone. The formation and function of the corpus luteum rely on the appropriate proliferation and differentiation of both granulosa and theca cells. If any aspect of granulosa or theca cell luteinization is perturbed, then the resulting luteal cell populations (SLC, LLC, vascular, and immune cells) may be reduced and compromise progesterone production. Thus, many factors that affect the differentiation/lineage of the somatic cells and their gene expression profiles can alter the ability of a corpus luteum to produce the progesterone critical for pregnancy. Our laboratory has identified genes that are enriched in somatic follicular cells and luteal cells through gene expression microarray. This work was the first to compare the gene expression profiles of the four somatic cell types involved in the follicle-to-luteal transition and to support previous immunofluorescence data indicating theca cells differentiate into SLCs while granulosa cells become LLCs. Using these data and incorporating knowledge about the ways in which luteinization can go awry, we can extrapolate the impact that alterations in the theca and granulosa cell gene expression profiles and lineages could have on the formation and function of the corpus luteum. While interactions with other cell types such as vascular and immune cells are critical for appropriate corpus luteum function, we are restricting this review to focus on granulosa, theca, and luteal cells and how perturbations such as androgen excess and inflammation may affect their function and fertility.
KW - androgen
KW - corpus luteum
KW - differentiation
KW - follicle
KW - granulosa cell
KW - infertility
KW - theca cell
U2 - 10.3389/fendo.2019.00832
DO - 10.3389/fendo.2019.00832
JO - Frontiers in Endocrinology
JF - Frontiers in Endocrinology