HomeResearchResearch ExplorerResearchersProf Nicholas Turner Publications
Prof Nicholas Turner
Professor of Chemical Biology
Chemical Biology and Biological Chemistry, School of Chemistry
CoEBio3 website
Nicholas.Turner@manchester.ac.uk
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A biocatalytic cascade for the amination of unfunctionalised cycloalkanes
Tavanti, M., Mangas-Sanchez, J., Montgomery, S. L., Thompson, M. P. & Turner, N. J., 14 Dec 2017, In : Organic and Biomolecular Chemistry. 15, 46, p. 9790-9793 4 p.
DOI: 10.1039/c7ob02569f
A fast and sensitive assay for measuring the activity and enantioselectivity of transaminases
Hopwood, J., Truppo, M. D., Turner, N. J. & Lloyd, R. C., 14 Jan 2011, In : Chemical Communications. 47, 2, p. 773-775 2 p.
DOI: 10.1039/c0cc02919j
A generic platform for the immobilisation of engineered biocatalysts
Thompson, M. P., Derrington, S. R., Heath, R. S., Porter, J. L., Mangas-Sanchez, J., Devine, P. N., Truppo, M. D. & Turner, N. J., 18 Jan 2019, In : Tetrahedron. 75, 3, p. 327-334 8 p.
DOI: 10.1016/j.tet.2018.12.004
A Mechanism for Reductive Amination Catalyzed by Fungal Reductive Aminases
Sharma, M., Mangas-Sanchez, J., France, S. P., Aleku, G. A., Montgomery, S. L., Ramsden, J. I., Turner, N. J. & Grogan, G., 7 Dec 2018, In : ACS Catalysis. 8, 12, p. 11534-11541 8 p.
DOI: 10.1021/acscatal.8b03491
A novel hyaluronan-based biomaterial (Hyaff-11®) as a scaffold for endothelial cells in tissue engineered vascular grafts
Turner, N. J., Kielty, C. M., Walker, M. G., Canfield, A. E. & Turner, N., Dec 2004, In : Biomaterials. 25, 28, p. 5955-5964 9 p.
DOI: 10.1016/j.biomaterials.2004.02.002
A panel of new thermostable CYP116B self-sufficient cytochrome P450 monooxygenases catalysing C-H activation with diverse substrate scope
Tavanti, M., Porter, J., Sabatini, S., Turner, N. & Flitsch, S., 2017, In : ChemCatChem.
DOI: 10.1002/cctc.201701510
A Reduction of C N to CH-NH Using Enzymes and Microorganisms
Turner, N., 2014, Comprehensive Organic Synthesis: Second Edition. Knochel, P. & Molander, G. A. (eds.). second ed. Vol. 8. p. 328-338
DOI: 10.1016/B978-0-08-097742-3.00810-7
A reductive aminase from Aspergillus oryzae
Aleku, G., France, S., Man, H., Mangas-Sanchez, J., Montgomery, S., Sharma, M., Leipold, F., Hussain, S., Grogan, G. & Turner, N., 2017, In : Nature Chemistry.
DOI: 10.1038/nchem.2782
A regio- and stereoselective ω-transaminase/monoamine oxidase cascade for the synthesis of chiral 2,5-disubstituted pyrrolidines
O'Reilly, E., Iglesias, C., Ghislieri, D., Hopwood, J., Galman, J. L., Lloyd, R. C. & Turner, N. J., 24 Feb 2014, In : Angewandte Chemie - International Edition. 53, 9, p. 2447-2450 3 p.
DOI: 10.1002/anie.201309208
A Single Enzyme Oxidative "cascade" via a Dual-Functional Galactose Oxidase
Birmingham, W. R. & Turner, N. J., 4 May 2018, In : ACS Catalysis. 8, 5, p. 4025-4032 8 p.
A stereospecific solid-phase screening assay for colonies expressing both (R)- and (S)-selective ω-aminotransferases
Willies, S., Galman, J., Slabu, I. & Turner, N., 11 Jan 2016, In : Royal Society of London. Proceedings A. Mathematical, Physical and Engineering Sciences.
DOI: 10.1098/rsta.2015.0084
A template-based mnemonic for monoamine oxidase (MAO-N) catalyzed reactions and its application to the chemo-enzymatic deracemisation of the alkaloid (±)-crispine A
Bailey, K. R., Ellis, A. J., Reiss, R., Snape, T. J. & Turner, N. J., 2007, In : Chemical Communications. 35, p. 3640-3642 2 p.
DOI: 10.1039/b710456a
A Versatile Chemo-Enzymatic Route to Enantiomerically Pure β-Branched α-Amino Acids
Roff, G. J., Lloyd, R. C. & Turner, N. J., 7 Apr 2004, In : Journal of the American Chemical Society. 126, 13, p. 4098-4099 1 p.
DOI: 10.1021/ja049499d
Absolute quantification of uric acid in human urine using surface enhanced Raman scattering with the standard addition method
Westley, C., Xu, Y., Thilaganathan, B., Carnell, A. J., Turner, N. & Goodacre, R., 21 Feb 2017, In : Analytical Chemistry. 89, 4, p. 2472–2477 6 p.
DOI: 10.1021/acs.analchem.6b04588
Achieving optimal SERS through enhanced experimental design
Turner, N., Fisk, H., Westley, C. & Goodacre, R., 16 Dec 2016, In : Journal of Raman Spectroscopy. 47, 1, p. 59-66
DOI: 10.1002/jrs.4855 10.1002/jrs.4855
Active site diversification of P450cam with indole generates catalysts for benzylic oxidation reactions
Flitsch, S., Kelly, P., Eichler, A., Herter, S., Kranz, D. C. & Turner, N., Sep 2015, In : Beilstein Journal of Organic Chemistry. 11, p. 1713-1720
DOI: 10.3762/bjoc.11.186
Adenylation Activity of Carboxylic Acid Reductases Enables the Synthesis of Amides
Wood, A., Weise, N., Frampton, J. D., Dunstan, M., Hollas, M., Derrington, S., Lloyd, R. C., Quaglia, D., Parmeggiani, F., Leys, D., Turner, N. & Flitsch, S., 13 Nov 2017, In : Angewandte Chemie. 56, 46, p. 14498-14501 4 p.
Ammonia lyases and aminomutases as biocatalysts for the synthesis of α-amino and β-amino acids
Turner, N. J., Apr 2011, In : Current Opinion in Chemical Biology. 15, 2, p. 234-240 6 p.
DOI: 10.1016/j.cbpa.2010.11.009
An (R)-Imine Reductase Biocatalyst for the Asymmetric Reduction of Cyclic Imines
Hussain, S., Leipold, F., Man, H., Wells, E., France, S. P., Mulholland, K. R., Grogan, G. & Turner, N., 21 Jan 2015, In : ChemCatChem (Online).
An automated Design-Build-Test-Learn pipeline for enhanced microbial production of fine chemicals
Carbonell, P., Jervis, A., Robinson, C., Yan, C., Dunstan, M., Swainston, N., Vinaixa, M., Hollywood, K., Currin, A., Rattray, N., Taylor, S., Spiess, R., Sung, R., Williams, A. R., Fellows, D., Stanford, N., Mulherin, P., Le Feuvre, R., Barran, P., Goodacre, R. & 9 othersTurner, N., Goble, C., Guoqiang Chen, G., Kell, D., Micklefield, J., Breitling, R., Takano, E., Faulon, J-L. & Scrutton, N., 2018, In : Communications Biology. 1, 66.
An Engineered Alcohol Oxidase for the Oxidation of Primary Alcohols
Heath, R. S., Birmingham, W. R., Thompson, M. P., Taglieber, A., Daviet, L. & Turner, N. J., 10 Dec 2018, In : CHEMBIOCHEM.
DOI: 10.1002/cbic.201800556
Application of Enzymes in Kinetic Resolutions, Dynamic Kinetic Resolutions and Deracemization Reactions
Humphrey, C., Ahmed, M., Ghanem, A. & Turner, N., 2014, Separation Of Enantiomers : Synthetic Methods. Todd, M. (ed.). p. 123-160
DOI: 10.1002/9783527650880.ch4
Applications of Phenylalanine Ammonia Lyases in Synthesis: Access to Enantiopure Arylalanines from Laboratory Scale to Industrial Production
Ahmed, S., Weise, N., Parmeggiani, F. & Turner, N., 2017, In : Chimica Oggi .
Artificial concurrent catalytic processes involving enzymes
Turner, N. & Köhler, V., 2015, In : Chemical Communications. 51, 3, p. 450-464
DOI: 10.1039/c4cc07277d
Asymmetric Synthesis of Tetracyclic Pyrroloindolines and Constrained Tryptamines by a Switchable Cascade Reaction
de Graaff, C., Bensch, L., Boersma, S. J., Cioc, R. C., Van Lint, M. J., Janssen, E., Turner, N., Orru, R. V. A. & Ruijter, E., 2015, In : Angewandte Chemie - International Edition. 54, 47, p. 14133-14136
Bacterial Anabaena variabilis phenylalanine ammonia lyase: A biocatalyst with broad substrate specificity
Lovelock, S. & Turner, N., 2014, In : Bioorganic and Medicinal Chemistry. 22, 20, p. 5555-5557
DOI: 10.1016/j.bmc.2014.06.035
Turner, N. J., Aug 2012, In : Catalysis Science and Technology. 2, 8, p. 1523
DOI: 10.1039/c2cy90030k
Biocatalysis - A gateway to industrial biotechnology
Fessner, W. D., Turner, N. J. & Wang, M. X., Sep 2011, In : Advanced synthesis & catalysis. 353, 13, p. 2189-2190 1 p.
DOI: 10.1002/adsc.201100679
Biocatalytic approaches to a key building block for the anti-thrombotic agent ticagrelor
Hugentobler, K. G., Sharif, H., Rasparini, M., Heath, R. S. & Turner, N. J., 2016, In : Organic and Biomolecular Chemistry. 14, 34, p. 8064-8067 4 p.
DOI: 10.1039/c6ob01382a
Biocatalytic approaches to the synthesis of enantiomerically pure chiral amines
Ghislieri, D. & Turner, N., 2014, In : Topics in Catalysis. 57, 5, p. 284-300
Biocatalytic conversion of cyclic ketones bearing α-quaternary stereocenters to lactones in an enantioselective radical approach to medium-sized carbocycles
Morrill, C., Jensen, C., Just-Baringo, X., Grogan, G., Turner, N. & Procter, D., 26 Mar 2018, In : Angewandte Chemie - International Edition. 57, 14, p. 3692-3696 4 p.
Biocatalytic desymmetrization of an atropisomer with both an enantioselective oxidase and ketoreductases
Yuan, B., Page, A., Worrall, C. P., Escalettes, F., Willies, S. C., McDouall, J. J. W., Turner, N. J. & Clayden, J., 17 Sep 2010, In : Angewandte Chemie - International Edition. 49, 39, p. 7010-7013 3 p.
Biocatalytic Dynamic Kinetic Resolution for the Synthesis of Atropisomeric Biaryl N-Oxide Lewis Base Catalysts
Staniland, S., Adams, R., Mcdouall, J., Maffucci, I., Contini, A., Grainger, D., Turner, N. & Clayden, J., 26 Aug 2016, In : Angewandte Chemie. 55, 36, p. 10755-10759 5 p.
Biocatalytic N-Alkylation of Amines Using Either Primary Alcohols or Carboxylic Acids via Reductive Aminase Cascades
Ramsden, J. I., Heath, R. S., Derrington, S. R., Montgomery, S. L., Mangas-Sanchez, J., Mulholland, K. R. & Turner, N. J., 23 Jan 2019, In : Journal of the American Chemical Society.
DOI: 10.1021/jacs.8b11561
Biocatalytic retrosynthesis: Redesigning synthetic routes to high-value chemicals
Turner, N. & Green, A., 14 Sep 2016, In : Perspectives in Science.
DOI: 10.1016/j.pisc.2016.04.106
Biocatalytic Routes to Enantiomerically Enriched Dibenz[c,e]azepines
France, S. P., Aleku, G. A., Sharma, M., Mangas-Sanchez, J., Howard, R. M., Steflik, J., Kumar, R., Adams, R. W., Slabu, I., Crook, R., Grogan, G., Wallace, T. W. & Turner, N. J., 2017, In : Angewandte Chemie - International Edition. 56, 49, p. 15589-15593 5 p.
Biocatalytic transamination with near-stoichiometric inexpensive amine donors mediated by bifunctional mono- and di-amine transaminases
Galman, J., Slabu, I., Weise, N., Iglesias, C., Parmeggiani, F., Lloyd, R. C. & Turner, N., 2017, In : Green Chemistry.
DOI: 10.1039/C6GC02102F
Bio-derived Production of Cinnamyl Alcohol via a Three Step Biocatalytic Cascade and Metabolic Engineering
Klumbys, E., Zebec, Z., Weise, N., Turner, N. & Scrutton, N., 2018, In : Green Chemistry.
DOI: 10.1039/C7GC03325G
Biomimetic synthesis of 2-substituted N-heterocycle alkaloids by one-pot hydrolysis, transamination and decarboxylative Mannich reaction
Galman, J. L., Slabu, I., Parmeggiani, F. & Turner, N. J., 2018, In : Chemical Communications. 54, 80, p. 11316-11319 4 p.
DOI: 10.1039/C8CC06759G
Biosynthesis and Characterization of Copper Nanoparticles Using Shewanella oneidensis: Application for Click Chemistry
Kimber, R., Lewis, E. A., Parmeggiani, F., Smith, K., Bagshaw, H., Starborg, T., Joshi, N., Figueroa, A. I., Van der Laan, G., Cibin, G., Gianolio, D., Haigh, S., Pattrick, R. A. D., Turner, N. & Lloyd, J., 2018, In : Small.
DOI: 10.1002/smll.201703145
Carboxylic acid reductase is a versatile enzyme for the conversion of fatty acids into fuels and chemical commodities
Kalim Akhtara, M., Turner, N. J. & Jones, P. R., 2 Jan 2013, In : Proceedings of the National Academy of Sciences of the United States of America. 110, 1, p. 87-92 5 p.
DOI: 10.1073/pnas.1216516110
Case Studies Illustrating a Science and Risk-Based Approach to Ensuring Drug Quality When Using Enzymes in the Manufacture of Active Pharmaceuticals Ingredients for Oral Dosage Form
Turner, N., Wells, A., Wong, J. W., Michels, P. C., Fandrick, K., Finch, G. L., Goswami, A., Lee, H., Mix, S., Moody, T., Pang, L., Entwistle, D. A., Sato, R. K. & Watson, T. J., 9 Feb 2016, In : Organic Process Research & Development. 20, 3, p. 3298-3306
DOI: 10.1021/acs.oprd.5b00369
Catalytic bio-chemo and bio-bio tandem oxidation reactions for amide and carboxylic acid synthesis
Bechi, B., Herter, S., McKenna, S., Riley, C., Leimkühler, S., Turner, N. J. & Carnell, A. J., 18 Aug 2014, In : Green Chemistry. 16, p. 4524-4529 5 p., C4GC01321B.
DOI: 10.1039/C4GC01321B
Characterisation of CYP102A25 from B. marmarensis and CYP102A26 from P. halophilus: P450 homologues of BM3 with preference towards hydroxylation of medium chain fatty acids
Porter, J., Manning, J., Sabatini, S., Tavanti, M., Turner, N. & Flitsch, S., 2017, In : ChemBioChem: a European journal of chemical biology .
Characterization of a new acidic NAD+-dependent formate dehydrogenase from thermophilic fungus Chaetomium thermophilum
Turner, N., Özgün, G., Karagüler, N. G. & Turunen, O., 2015, In : Journal of Molecular Catalysis B: Enzymatic. 122, p. 212-217
DOI: 10.1016/j.molcatb.2015.09.014
Chemo-biocatalytic one-pot two-step conversion of cyclic amine to lactam using whole cell monoamine oxidase
Zajkoska, P., Cárdenas-Fernández, M., Lye, G. J., Rosenberg, M., Turner, N. J. & Rebroš, M., 1 Jul 2017, In : Journal of Chemical Technology and Biotechnology. 92, 7, p. 1558-1565 8 p.
DOI: 10.1002/jctb.5146
Chemoenzymatic Synthesis of Optically Pure L- and D-Biarylalanines through Biocatalytic Asymmetric Amination and Palladium-Catalyzed Arylation
Ahmed, S., Parmeggiani, F., Weise, N., Flitsch, S. & Turner, N., Sep 2015, In : ACS Catalysis. 5, p. 5410-5413
Chemo-enzymatic synthesis of pyrazines and pyrroles
Turner, N. J., Green, A. & Xu, J., 2018, In : Angewandte Chemie International Edition.
Chemoenzymatic Synthesis of Substituted Azepanes by Sequential Biocatalytic Reduction and Organolithium-Mediated Rearrangement
Zawodny, W., Montgomery, S. L., Marshall, J. R., Finnigan, J. D., Turner, N. J. & Clayden, J., 26 Dec 2018, In : Journal of the American Chemical Society. 140, 51, p. 17872-17877 6 p.
Chimeric self-sufficient P450cam-RhFRed biocatalysts with broad substrate scope
Robin, A., Köhler, V., Jones, A., Ali, A., Kelly, P. P., O'Reilly, E., Turner, N. J. & Flitsch, S. L., 2 Nov 2011, In : Beilstein Journal of Organic Chemistry. 7, p. 1494-1498 4 p., 7.
DOI: 10.3762/bjoc.7.173
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Label-Free Surface Enhanced Raman Scattering Approach for High-Throughput Screening of Biocatalysts
The self‐sufficient P450 RhF expressed in a whole cell system selectively catalyses the 5‐hydroxylation of diclofenac
Intensified biocatalytic production of enantiomerically pure halophenylalanines from acrylic acids using ammonium carbamate as the ammonia source