Bone and Bones
Hematopoietic Stem Cells
Stromal Cells
Bone Matrix
Osteoblasts
Osteoclasts
Megakaryocytes
T-Lymphocytes
Mesenchymal Stromal Cells
Plasma Cells
Radiation Chimera
Transplantation Chimera
Mice, Inbred Strains
Diseases 28
Bone Marrow Neoplasms
Bone Marrow Diseases
Bone Resorption
Bone Neoplasms
Bone Diseases
Graft vs Host Disease
Anemia, Aplastic
Pancreatic Neoplasms
Leukemia, Myeloid, Acute
Pancytopenia
Myeloproliferative Disorders
Bone Diseases, Metabolic
Primary Myelofibrosis
Neoplasms, Cystic, Mucinous, and Serous
Leukemia, Myeloid
Hematologic Neoplasms
Fractures, Bone
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Neoplasms, Second Primary
Neoplasms, Multiple Primary
Antigens, CD34
Antigens, CD
Bone Morphogenetic Protein 2
Bone Marrow Transplantation
Bone Marrow Examination
Bone Marrow Purging
Transplantation, Homologous
Transplantation, Autologous
Bone Transplantation
Hematopoietic Stem Cell Transplantation
Cell Count
Leukocyte Count
Blood Cell Count
Transplantation Conditioning
Phenomena and Processes 18
Hematopoiesis
Bone Development
Bone Regeneration
Osteogenesis
Cell Lineage
Graft Survival
Erythropoiesis
Named Groups 1
Tissue Donors
AnatomyOrganismsDiseasesAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
Bone Marrow NeoplasmsBone MarrowBone Marrow CellsBone Marrow TransplantationBone and BonesBone RemodelingBone Marrow DiseasesBone Marrow ExaminationHematopoietic Stem CellsBone DensityBone ResorptionBone NeoplasmsBone Marrow PurgingHematopoiesisTransplantation, HomologousBone DevelopmentMice, Inbred C57BLCell DifferentiationColony-Forming Units AssayBone DiseasesBone RegenerationCells, CulturedTransplantation, AutologousWhole-Body IrradiationLeukemia
Event-free survival [ Time Frame: om study entry to disease progression, disease relapse, occurrence of a second malignant neoplasm, or death from any cause. (clinicaltrials.gov)
myeloid
Acute myeloblastic leukemia (AML) is a group of malignant bone marrow neoplasms of myeloid precursors of white blood cells. (wikipedia.org)
Thus, although all blood cells, even lymphocytes, are normally born in the bone marrow in adults, myeloid cells in the narrowest sense of the term can be distinguished from lymphoid cells, that is, lymphocytes, which come from common lymphoid progenitor cells that give rise to B cells and T cells. (wikipedia.org)
The word myelopoiesis has several senses in a way that parallels those of myeloid, and myelopoiesis in the narrower sense is the regulated formation specifically of myeloid leukocytes (myelocytes), allowing that sense of myelopoiesis to be contradistinguished from erythropoiesis and lymphopoiesis (even though all blood cells are normally produced in the marrow in adults). (wikipedia.org)
Myeloid neoplasms always concern bone marrow cell lineage and are related to hematopoietic cells. (wikipedia.org)
There are four main myeloproliferative diseases, which can be further categorized by the presence of the Philadelphia chromosome:[citation needed] In 2008, the World Health Organization listed these diagnoses as types of MPD: Chronic myelogenous leukemia (BCR-ABL1-positive) Chronic neutrophilic leukemia Polycythemia vera Primary myelofibrosis Essential thrombocythemia Chronic eosinophilic leukemia (not otherwise specified) Mastocytosis All MPNs arise from precursors of the myeloid lineages in the bone marrow. (wikipedia.org)
Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm that features a persistent neutrophilia in peripheral blood, myeloid hyperplasia in bone marrow, hepatosplenomegaly, and the absence of the Philadelphia chromosome or a BCR/ABL fusion gene. (wikipedia.org)
On both the bone marrow aspirate and the core biopsy, a hypercellular marrow with an increased myeloid:erythroid ratio of 20:1 or greater. (wikipedia.org)
Myelofibrosis is a form of myeloid metaplasia, which refers to a change in cell type in the blood-forming tissue of the bone marrow, and often the two terms are used synonymously. (wikipedia.org)
Discovery of genetic mutations underlining these eosinophilia syndromes lead to their removal from CEL-NOS or HES categories and classification as myeloid and lymphoid neoplasms associated with eosinophilia and abnormalities of PDGFRA, PDGFRB, FGFR1, and, tentatively, PCMA-JAK2. (wikipedia.org)
Myeloproliferative
The myeloproliferative neoplasms (MPNs), previously myeloproliferative diseases (MPDs), are a group of diseases of the bone marrow in which excess cells are produced. (wikipedia.org)
citation needed] Depending on the nature of the myeloproliferative neoplasm, diagnostic tests may include red cell mass determination (for polycythemia), bone marrow aspirate and trephine biopsy, arterial oxygen saturation and carboxyhaemoglobin level, neutrophil alkaline phosphatase level, vitamin B12 (or B12 binding capacity), serum urate or direct sequencing of the patient's DNA. (wikipedia.org)
Trials of these inhibitors are in progress for the treatment of the other myeloproliferative neoplasms. (wikipedia.org)
It is currently classified as a myeloproliferative neoplasm, in which the proliferation of an abnormal clone of hematopoietic stem cells in the bone marrow and other sites results in fibrosis, or the replacement of the marrow with scar tissue. (wikipedia.org)
It is one of the myeloproliferative disorders, diseases of the bone marrow in which excess cells are produced at some stage. (wikipedia.org)
Eye neoplasms can affect all parts of the eye, and can be a benign tumor or a malignant tumor (cancer). (wikipedia.org)
Although not a malignant neoplasm like other cancers, MPNs are classified within the hematological neoplasms. (wikipedia.org)
High doses of etoposide along with other chemotherapy drugs have been used with autologous bone marrow transplant for refractory advanced malignant neoplasms. (dmoztools.net)
Clonal hypereosinophilia, also termed Primary hypereosinophelia or clonal eosinophilia, is a grouping of hematological disorder characterized by the development and growth of a pre-malignant or malignant population of eosinophils, a type of white blood cell, in the bone marrow, blood, and/or other tissues. (wikipedia.org)
On December 9, 2013, Rosa's manager confirmed his cancer had relapsed and overcame cancer once again after a second bone marrow transplant, but had to remain in quarantine for four additional months. (wikipedia.org)
Allogeneic bone marrow transplant has been proven to attain remission for over five years and possibly cure hepatosplenic lymphoma. (wikipedia.org)
autologous
Autologous bone marrow transplantation is currently being investigated in the treatment of hepatosplenic lymphoma. (wikipedia.org)
allogeneic
Treatment includes intensive multidrug chemotherapy and in selected cases allogeneic bone marrow transplantation. (wikipedia.org)
Peripheral blood, bone marrow, spleen, and liver are most common, but any organ or tissue can be infiltrated by neutrophils. (wikipedia.org)
The primary sign of myelofibrosis is reactive bone marrow fibrosis, but it is often accompanied by: Abdominal fullness related to an enlarged spleen (splenomegaly). (wikipedia.org)
Bone pain Bruising and easy bleeding due to inadequate numbers of platelets Cachexia (loss of appetite, weight loss, and fatigue) Enlargement of both the liver and spleen Fatigue Gout and high uric acid levels Increased susceptibility to infection, such as pneumonia Pallor and shortness of breath due to anemia In rarer cases, a raised red blood cell volume Cutaneous myelofibrosis is a rare skin condition characterized by dermal and subcutaneous nodules. (wikipedia.org)
The result is extramedullary hematopoiesis, i.e. blood cell formation occurring in sites other than the bone marrow, as the haemopoetic cells are forced to migrate to other areas, particularly the liver and spleen. (wikipedia.org)
Hepatosplenic T-cell lymphoma is a systemic neoplasm comprising medium-sized cytotoxic T-cells that show a significant sinusoidal infiltration in the liver, spleen, and bone marrow. (wikipedia.org)
The spleen and liver are always involved, with bone marrow involvement frequently present. (wikipedia.org)
Polycythemia
Polycythemia vera is an uncommon neoplasm in which the bone marrow makes too many red blood cells. (wikipedia.org)
The expanding population of eosinophils, initially formed in the bone marrow may spread to the blood and then enter into and injure various tissues and organs. (wikipedia.org)
Some hematological malignancies exhibit increased numbers of circulating blood eosinophils, increased numbers of bone marrow eosinophils, and/or eosinophil infiltrations into otherwise normal tissues. (wikipedia.org)
These aberrant lymphocytes function abnormally by stimulating the proliferation and maturation of bone marrow eosinophil-precursor cells termed colony forming unit-Eosinophils or CFU-Eos. (wikipedia.org)
There is a reported association between CNL and multiple myeloma, so the bone marrow biopsy may show evidence of a plasma cell dyscrasia with increased numbers of atypical plasma cells. (wikipedia.org)
aspirate
Diagnostic methods include blood analysis, bone marrow aspirate for cytochemical, immunological and cytogeneticalanalysis, and cerebrospinal fluid (CSF) investigations. (wikipedia.org)
Of solid tumor neoplasms, ovarian cancer is most likely to provoke eosinophilia, though any other cancer can cause the condition. (wikipedia.org)
Production of cytokines such as fibroblast growth factor by the abnormal hematopoietic cell clone (particularly by megakaryocytes) leads to replacement of the hematopoietic tissue of the bone marrow by connective tissue via collagen fibrosis. (wikipedia.org)
Histiocytic sarcoma Localized histiocytic sarcoma diffuse histiocytic sarcoma Histiocytoma is a common, benign, cutaneous neoplasm in dogs. (wikipedia.org)
neoplastic
While the bone marrow is commonly involved, the detection of the neoplastic infiltrate may be difficult due to diffuse, interstitial pattern. (wikipedia.org)
commonly
A classic example of such a disease is chronic myelogenous leukemia, a neoplasm commonly caused by a mutation that creates the BCR-ABL1 fusion gene (see Philadelphia chromosome). (wikipedia.org)
abnormal
There may be signs of specific causes of anemia, e.g., koilonychia (in iron deficiency), jaundice (when anemia results from abnormal break down of red blood cells - in hemolytic anemia), bone deformities (found in thalassemia major) or leg ulcers (seen in sickle-cell disease). (wikipedia.org)
The abnormal megakaryocytes stimulate other cells, the fibroblasts, to produce collagen in the bone marrow. (wikipedia.org)
Absent these causes, patients were diagnosed in the World Health Organization's classification as having either 1) Chronic eosinophilic leukemia, not otherwise specified, (CEL-NOS) if blood or bone marrow blast cells exceeded 2% or 5% of total nucleated cells, respectively, and other criteria were met or 2) idiopathic hypereosinophilic syndrome (HES) if there was evidence of eosinophil-induced tissue damage but no criteria indicating chronic eosinophilic leukemia. (wikipedia.org)
The postulated cell of origin is a limited-potential, marrow-derived stem cell. (wikipedia.org)
Causes of decreased production include iron deficiency, a lack of vitamin B12, thalassemia, and a number of neoplasms of the bone marrow. (wikipedia.org)
Other less common sites of origin include the prostate, kidney, thyroid, skin, colon and blood or bone marrow. (wikipedia.org)
Myelofibrosis, also known as osteomyelofibrosis, is a relatively rare bone marrow cancer. (wikipedia.org)
The Philadelphia chromosome negative myeloproliferative neoplasms (MPN) are a group of clonal hematological malignancies that are characterized by a chronic course which can be punctuated by a number of disease related events including thrombosis, hemorrhage, pruritis and leukemic transformation. (clinicaltrials.gov)
hematopoietic cells
Using a bone marrow reconstitution assay with cells containing retrovirally transduced TAN1 alleles, we analyzed the oncogenic potential of both nuclear and extranuclear forms of truncated TAN1 in hematopoietic cells. (rupress.org)
hematological
Myelofibrosis
Myelofibrosis is the gradual replacement of bone marrow (place where most new blood cells are produced) by fibrous tissue which reduces the body's ability to produce new blood cells and results in the development of chronic anemia (low red blood cell count). (clinicaltrials.gov)
RESULTS: Among 19 patients treated for NB resistant to induction therapy, 12 of 15 had complete remission (CR) of bone marrow (BM) disease, and three others who had less than partial responses achieved prolonged progression-free survival (one remains on study at 21+ months, two had PD at 12 and 17 months). (mendeley.com)
abnormal clone
Considering the lack of effective therapeutic strategy targeted at the mutated allele JAK2V617F, there is no known treatment that eradicates the abnormal clone, apart from anecdotal cases of bone marrow transplantation. (clinicaltrials.gov)
The concept that vascular structures support HSPC has long been proposed and is in keeping with the growing idea that definitive hematopoiesis and establishment of a HSPC pool exists well before bone or bone marrow formation. (haematologica.org)
Given that leukemia does not propagate just anywhere in the body and is difficult to grow ex vivo , it was thought that leukemia cells depend on the bone marrow microenvironment (BMM). (haematologica.org)
Less well understood, but of growing interest, is the interaction between cells in the bone marrow during the initiation, maintenance and treatment of hematologic neoplasms. (haematologica.org)