Actions of a novel synthetic natriuretic peptide on hemodynamics and ventricular function in the dog
John G. Lainchbury, Ondrej Lisy, John C Jr. Burnett, Donna M. Meyer, Margaret May Redfield
Dendroaspis natriuretic peptide (DNP) is a recently discovered peptide with structural similarity to known natriuretic peptides. DNP has been shown to possess potent renal actions. Our objectives were to define the acute hemodynamic actions of DNP in normal anesthetized dogs and the acute effects of DNP on left ventricular (LV) function in conscious chronically instrumented dogs. In anesthetized dogs, DNP, but not placebo, decreased mean arterial pressure (141 ± 6 to 109 ± 7 mmHg, P < 0.05) and pulmonary capillary wedge pressure (5.8 ± 0.3 to 3.4 ± 0.2 mmHg, P < 0.05). Cardiac output decreased and systemic vascular resistance increased with DNP and placebo. DNP-like immunoreactivity and guanosine 3′,5′-cyclic monophosphate concentration increased without changes in other natriuretic peptides. In conscious dogs, DNP decreased LV end-systolic pressure (120 ± 7 to 102 ± 6 mmHg, P < 0.05) and volume (32 ± 6 to 28 ± 6 ml, P < 0.05) and LV end-diastolic volume (38 ± 5 to 31 ± 4 ml, P < 0.05) but not arterial elastance. LV end-systolic elastance increased (6.1 ± 0.7 to 7.4 ± 0.6 mmHg/ml, P < 0.05), and Tau decreased (31 ± 2 to 27 ± 1 ms, P < 0.05). The effects on hemodynamics, LV function, and second messenger generation suggest synthetic DNP may have a role as a cardiac unloading and lusitropic peptide.
American Journal of Physiology - Regulatory Integrative and Comparative Physiology
4 51-4
Ventricular Function
Left Ventricular Function
Dendroaspis natriuretic peptide
Pulmonary Wedge Pressure
Guanosine
Second Messenger Systems
Cardiac Output
Vascular Resistance
Arterial Pressure
Diastolic function
Systolic function
Lainchbury, J. G., Lisy, O., Burnett, J. C. J., Meyer, D. M., & Redfield, M. M. (2002). Actions of a novel synthetic natriuretic peptide on hemodynamics and ventricular function in the dog. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 282(4 51-4).
Actions of a novel synthetic natriuretic peptide on hemodynamics and ventricular function in the dog. / Lainchbury, John G.; Lisy, Ondrej; Burnett, John C Jr.; Meyer, Donna M.; Redfield, Margaret May.
In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 282, No. 4 51-4, 2002.
Lainchbury, JG, Lisy, O, Burnett, JCJ, Meyer, DM & Redfield, MM 2002, 'Actions of a novel synthetic natriuretic peptide on hemodynamics and ventricular function in the dog', American Journal of Physiology - Regulatory Integrative and Comparative Physiology, vol. 282, no. 4 51-4.
Lainchbury JG, Lisy O, Burnett JCJ, Meyer DM, Redfield MM. Actions of a novel synthetic natriuretic peptide on hemodynamics and ventricular function in the dog. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2002;282(4 51-4).
Lainchbury, John G. ; Lisy, Ondrej ; Burnett, John C Jr. ; Meyer, Donna M. ; Redfield, Margaret May. / Actions of a novel synthetic natriuretic peptide on hemodynamics and ventricular function in the dog. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 2002 ; Vol. 282, No. 4 51-4.
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title = "Actions of a novel synthetic natriuretic peptide on hemodynamics and ventricular function in the dog",
abstract = "Dendroaspis natriuretic peptide (DNP) is a recently discovered peptide with structural similarity to known natriuretic peptides. DNP has been shown to possess potent renal actions. Our objectives were to define the acute hemodynamic actions of DNP in normal anesthetized dogs and the acute effects of DNP on left ventricular (LV) function in conscious chronically instrumented dogs. In anesthetized dogs, DNP, but not placebo, decreased mean arterial pressure (141 ± 6 to 109 ± 7 mmHg, P < 0.05) and pulmonary capillary wedge pressure (5.8 ± 0.3 to 3.4 ± 0.2 mmHg, P < 0.05). Cardiac output decreased and systemic vascular resistance increased with DNP and placebo. DNP-like immunoreactivity and guanosine 3′,5′-cyclic monophosphate concentration increased without changes in other natriuretic peptides. In conscious dogs, DNP decreased LV end-systolic pressure (120 ± 7 to 102 ± 6 mmHg, P < 0.05) and volume (32 ± 6 to 28 ± 6 ml, P < 0.05) and LV end-diastolic volume (38 ± 5 to 31 ± 4 ml, P < 0.05) but not arterial elastance. LV end-systolic elastance increased (6.1 ± 0.7 to 7.4 ± 0.6 mmHg/ml, P < 0.05), and Tau decreased (31 ± 2 to 27 ± 1 ms, P < 0.05). The effects on hemodynamics, LV function, and second messenger generation suggest synthetic DNP may have a role as a cardiac unloading and lusitropic peptide.",
keywords = "Diastolic function, Natriuretic peptides, Systolic function",
author = "Lainchbury, {John G.} and Ondrej Lisy and Burnett, {John C Jr.} and Meyer, {Donna M.} and Redfield, {Margaret May}",
journal = "American Journal of Physiology - Renal Fluid and Electrolyte Physiology",
number = "4 51-4",
T1 - Actions of a novel synthetic natriuretic peptide on hemodynamics and ventricular function in the dog
AU - Lainchbury, John G.
AU - Lisy, Ondrej
AU - Burnett, John C Jr.
AU - Meyer, Donna M.
AU - Redfield, Margaret May
N2 - Dendroaspis natriuretic peptide (DNP) is a recently discovered peptide with structural similarity to known natriuretic peptides. DNP has been shown to possess potent renal actions. Our objectives were to define the acute hemodynamic actions of DNP in normal anesthetized dogs and the acute effects of DNP on left ventricular (LV) function in conscious chronically instrumented dogs. In anesthetized dogs, DNP, but not placebo, decreased mean arterial pressure (141 ± 6 to 109 ± 7 mmHg, P < 0.05) and pulmonary capillary wedge pressure (5.8 ± 0.3 to 3.4 ± 0.2 mmHg, P < 0.05). Cardiac output decreased and systemic vascular resistance increased with DNP and placebo. DNP-like immunoreactivity and guanosine 3′,5′-cyclic monophosphate concentration increased without changes in other natriuretic peptides. In conscious dogs, DNP decreased LV end-systolic pressure (120 ± 7 to 102 ± 6 mmHg, P < 0.05) and volume (32 ± 6 to 28 ± 6 ml, P < 0.05) and LV end-diastolic volume (38 ± 5 to 31 ± 4 ml, P < 0.05) but not arterial elastance. LV end-systolic elastance increased (6.1 ± 0.7 to 7.4 ± 0.6 mmHg/ml, P < 0.05), and Tau decreased (31 ± 2 to 27 ± 1 ms, P < 0.05). The effects on hemodynamics, LV function, and second messenger generation suggest synthetic DNP may have a role as a cardiac unloading and lusitropic peptide.
AB - Dendroaspis natriuretic peptide (DNP) is a recently discovered peptide with structural similarity to known natriuretic peptides. DNP has been shown to possess potent renal actions. Our objectives were to define the acute hemodynamic actions of DNP in normal anesthetized dogs and the acute effects of DNP on left ventricular (LV) function in conscious chronically instrumented dogs. In anesthetized dogs, DNP, but not placebo, decreased mean arterial pressure (141 ± 6 to 109 ± 7 mmHg, P < 0.05) and pulmonary capillary wedge pressure (5.8 ± 0.3 to 3.4 ± 0.2 mmHg, P < 0.05). Cardiac output decreased and systemic vascular resistance increased with DNP and placebo. DNP-like immunoreactivity and guanosine 3′,5′-cyclic monophosphate concentration increased without changes in other natriuretic peptides. In conscious dogs, DNP decreased LV end-systolic pressure (120 ± 7 to 102 ± 6 mmHg, P < 0.05) and volume (32 ± 6 to 28 ± 6 ml, P < 0.05) and LV end-diastolic volume (38 ± 5 to 31 ± 4 ml, P < 0.05) but not arterial elastance. LV end-systolic elastance increased (6.1 ± 0.7 to 7.4 ± 0.6 mmHg/ml, P < 0.05), and Tau decreased (31 ± 2 to 27 ± 1 ms, P < 0.05). The effects on hemodynamics, LV function, and second messenger generation suggest synthetic DNP may have a role as a cardiac unloading and lusitropic peptide.
KW - Diastolic function
KW - Natriuretic peptides
KW - Systolic function
JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
IS - 4 51-4