clinical subgroups and histocompatibility antigens
N J McHugh, M R Laurent, B L Treadwell, J M Tweed, J Dagger
Histocompatibility antigens were determined in 60 patients with psoriatic arthritis. The patients were divided into clinical subgroups according to axial or peripheral joint involvement, disease severity based on number of peripheral joints involved, and the presence or absence of bone erosions. The total group showed a significant increase in frequency of HLA-A1, B17, B27, and DR7 when compared with a control population. The subgroup with spondylitis had a significant increase in frequency of HLA-B27 when compared with patients with peripheral arthritis (p less than 0.001). The subgroup with peripheral arthritis alone had a higher frequency of HLA-DR7 than the control group (p less than 0.001). There were also significant associations between HLA-DR7 and chronic severe disease (p less than 0.001) and between HLA-DR4 and the presence of erosions (p less than 0.05).
Annals of the Rheumatic Diseases
https://doi.org/10.1136/ard.46.3.184
HLA-DR7 Antigen
HLA-A1 Antigen
HLA-B27 Antigen
Joint Diseases
McHugh, N. J., Laurent, M. R., Treadwell, B. L., Tweed, J. M., & Dagger, J. (1987). Psoriatic arthritis: clinical subgroups and histocompatibility antigens. Annals of the Rheumatic Diseases, 46(3), 184-8. https://doi.org/10.1136/ard.46.3.184
Psoriatic arthritis : clinical subgroups and histocompatibility antigens. / McHugh, N J; Laurent, M R; Treadwell, B L; Tweed, J M; Dagger, J.
In: Annals of the Rheumatic Diseases, Vol. 46, No. 3, 03.1987, p. 184-8.
McHugh, NJ, Laurent, MR, Treadwell, BL, Tweed, JM & Dagger, J 1987, 'Psoriatic arthritis: clinical subgroups and histocompatibility antigens', Annals of the Rheumatic Diseases, vol. 46, no. 3, pp. 184-8. https://doi.org/10.1136/ard.46.3.184
McHugh NJ, Laurent MR, Treadwell BL, Tweed JM, Dagger J. Psoriatic arthritis: clinical subgroups and histocompatibility antigens. Annals of the Rheumatic Diseases. 1987 Mar;46(3):184-8. https://doi.org/10.1136/ard.46.3.184
McHugh, N J ; Laurent, M R ; Treadwell, B L ; Tweed, J M ; Dagger, J. / Psoriatic arthritis : clinical subgroups and histocompatibility antigens. In: Annals of the Rheumatic Diseases. 1987 ; Vol. 46, No. 3. pp. 184-8.
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title = "Psoriatic arthritis: clinical subgroups and histocompatibility antigens",
abstract = "Histocompatibility antigens were determined in 60 patients with psoriatic arthritis. The patients were divided into clinical subgroups according to axial or peripheral joint involvement, disease severity based on number of peripheral joints involved, and the presence or absence of bone erosions. The total group showed a significant increase in frequency of HLA-A1, B17, B27, and DR7 when compared with a control population. The subgroup with spondylitis had a significant increase in frequency of HLA-B27 when compared with patients with peripheral arthritis (p less than 0.001). The subgroup with peripheral arthritis alone had a higher frequency of HLA-DR7 than the control group (p less than 0.001). There were also significant associations between HLA-DR7 and chronic severe disease (p less than 0.001) and between HLA-DR4 and the presence of erosions (p less than 0.05).",
keywords = "Arthritis, Female, HLA Antigens, Humans, Male, Psoriasis",
author = "McHugh, {N J} and Laurent, {M R} and Treadwell, {B L} and Tweed, {J M} and J Dagger",
doi = "10.1136/ard.46.3.184",
pages = "184--8",
journal = "Annals of the Rheumatic Diseases",
publisher = "BMJ Publishing Group Ltd",
T1 - Psoriatic arthritis
T2 - clinical subgroups and histocompatibility antigens
AU - McHugh, N J
AU - Laurent, M R
AU - Treadwell, B L
AU - Tweed, J M
AU - Dagger, J
N2 - Histocompatibility antigens were determined in 60 patients with psoriatic arthritis. The patients were divided into clinical subgroups according to axial or peripheral joint involvement, disease severity based on number of peripheral joints involved, and the presence or absence of bone erosions. The total group showed a significant increase in frequency of HLA-A1, B17, B27, and DR7 when compared with a control population. The subgroup with spondylitis had a significant increase in frequency of HLA-B27 when compared with patients with peripheral arthritis (p less than 0.001). The subgroup with peripheral arthritis alone had a higher frequency of HLA-DR7 than the control group (p less than 0.001). There were also significant associations between HLA-DR7 and chronic severe disease (p less than 0.001) and between HLA-DR4 and the presence of erosions (p less than 0.05).
AB - Histocompatibility antigens were determined in 60 patients with psoriatic arthritis. The patients were divided into clinical subgroups according to axial or peripheral joint involvement, disease severity based on number of peripheral joints involved, and the presence or absence of bone erosions. The total group showed a significant increase in frequency of HLA-A1, B17, B27, and DR7 when compared with a control population. The subgroup with spondylitis had a significant increase in frequency of HLA-B27 when compared with patients with peripheral arthritis (p less than 0.001). The subgroup with peripheral arthritis alone had a higher frequency of HLA-DR7 than the control group (p less than 0.001). There were also significant associations between HLA-DR7 and chronic severe disease (p less than 0.001) and between HLA-DR4 and the presence of erosions (p less than 0.05).
KW - Arthritis
KW - Female
KW - HLA Antigens
KW - Humans
KW - Male
KW - Psoriasis
UR - http://dx.doi.org/10.1136/ard.46.3.184
U2 - 10.1136/ard.46.3.184
DO - 10.1136/ard.46.3.184
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
10.1136/ard.46.3.184
http://dx.doi.org/10.1136/ard.46.3.184