January 2001 - Volume 7 - Issue 1
Select an option Log In Buy Article Subscribe Content & Permissions Ovid Member Institutional Access
Thought you might appreciate this item(s) I saw at Current Opinion in Pulmonary Medicine.
The role of particulate pollutants in pulmonary inflammation and asthma: evidence for the involvement of organic chemicals and oxidative stress
Nel, Andre E. MD, PhD; Diaz-Sanchez, David PhD; Li, Ning MD, PhD
Department of Medicine/Division of Clinical Immunology and Allergy, University of California Los Angeles, Los Angeles, California, USA.
Correspondence to Andre E. Nel, Department of Medicine/Division of Clinical Immunology and Allergy, University of California Los Angeles, 10833 Le Conte Ave., 52-175CHS, Los Angeles, CA 90095, USA; e-mail: [email protected]
Current Opinion in Pulmonary Medicine: January 2001 - Volume 7 - Issue 1 - p 20-26
We review the literature indicating that the adverse health effects of ambient particulate matter involve the generation of oxidative stress and inflammation, as well as immunomodulating effects by particle-associated chemicals. We discuss evidence that diesel exhaust particle organic extracts induce reactive oxygen species in macrophages and bronchial epithelial cells, two key cell types targeted by particulate matter in the lung. Reactive oxygen species activate the promoters of cytokines and chemokines involved in allergic inflammation through activator protein-1 and nuclear factor- κB signaling pathways, which may explain exacerbation of allergic inflammation. Organic diesel exhaust particle chemicals also induce apoptosis and necrosis in bronchial epithelial cells via a mitochondrial pathway. This may be responsible for epithelial shedding and bronchial hyperreactivity in asthma.
© 2001 Lippincott Williams & Wilkins, Inc.
Current Opinion in Pulmonary Medicine7(1):20-26, January 2001.
Articles in PubMed by Andre E. Nel, MD, PhD
Articles in Google Scholar by Andre E. Nel, MD, PhD
Other articles in this journal by Andre E. Nel, MD, PhD