Mefloquine Failure in a Case of Falciparum Malaria Induced with a Multidrug-Resistant Isolate in a Non-Immune Subject
Thomas M. Cosgriff, Charles L. Pamplin, Craig J. Canfield, Gloria P. Willet
Affiliations: 1 Division of Experimental Therapeutics, Walter Reed Army Institute of Research, Washington, DC 20307-5100
Source: The American Journal of Tropical Medicine and Hygiene, Volume 34, Issue 4, 1 Jul 1985, p. 692 - 693
DOI: https://doi.org/10.4269/ajtmh.1985.34.692
In a volunteer with infection induced by injection of the mefloquine-sensitive, multidrug-resistant Vietnam Smith isolate of P. falciparum, parasitemia recurred following treatment with the candidate antimalarial drug enpiroline. Parasitemia also recurred after subsequent treatment with mefloquine and again after retreatment with the same drug. All recurrences were at the RI level. Parasite drug sensitivities determined by a semi-automated isotope microdilution method after the second and third recurrences revealed a progressive decrease in sensitivity to all arylaminoalcohols tested (halofantrine, enpiroline, and mefloquine). Decreased sensitivity persisted after 30 days of isolate culture. The parallel changes in parasite sensitivity to the synthetic arylaminoalcohols argue for development of drugs which are chemically dissimilar.
Copyright © 1985 by The American Society of Tropical Medicine and Hygiene
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Accepted : 04 Mar 1985
10.4269/ajtmh.1985.34.692