Tubal Ligation and Age at Natural Menopause
Alessandra J. Ainsworth, Sarah C. Baumgarten, Jamie N. Bakkum-Gamez, Celine M. Vachon, Amy L. Weaver, Shannon K. Laughlin-Tommaso
Quantitative Health Sciences
Objective: To determine the effect of tubal ligation on age at natural menopause, as a marker of long-term ovarian function. Methods: Three preexisting population-based cohorts were included in this cross-sectional study. Data from each cohort was analyzed separately. The cohorts were restricted to women who never smoked and had reached natural menopause, without prior hysterectomy or oophorectomy. The following variables were collected: race, age at menarche, age at menopause, history of hysterectomy or oophorectomy, gravidity and parity, tobacco use, and ever use of hormonal contraception. The type of tubal ligation and age at tubal ligation were manually abstracted in cohort 1. For cohorts 2 and 3, history of tubal ligation was obtained from an institutional form, completed by patient report. The primary outcome, age at natural menopause, was compared between the two groups (those with and without a history of tubal ligation). Results: Inclusion criteria was met by 555 women from cohort 1, 1,816 women from cohort 2, and 1,534 women from cohort 3. Baseline characteristics did not differ between cohorts. The percentage with tubal ligation was the same in all cohorts: 26.0%, 25.5%, and 25.0%, respectively. Women with a tubal ligation were more likely to have had at least one pregnancy and to have used hormonal contraception compared with women without a tubal ligation. There was no significant difference in age at natural menopause in women who underwent tubal ligation (50.1, 49.9, 50.0 years, respectively) compared with those who did not (50.7, 49.6, 50.0 years, respectively). The type of tubal ligation (cohort 1 only) had no effect on age at menopause. Conclusions: Tubal ligation did not affect age at natural menopause in the three large cohorts included in this study.
https://doi.org/10.1097/AOG.0000000000003266
10.1097/AOG.0000000000003266
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Tubal Sterilization Medicine & Life Sciences 100%
Menopause Medicine & Life Sciences 77%
Hormonal Contraception Medicine & Life Sciences 19%
Ovariectomy Medicine & Life Sciences 15%
Hysterectomy Medicine & Life Sciences 13%
Gravidity Medicine & Life Sciences 9%
Menarche Medicine & Life Sciences 8%
Tobacco Use Medicine & Life Sciences 7%
Ainsworth, A. J., Baumgarten, S. C., Bakkum-Gamez, J. N., Vachon, C. M., Weaver, A. L., & Laughlin-Tommaso, S. K. (2019). Tubal Ligation and Age at Natural Menopause. Obstetrics and gynecology, 133(6), 1247-1254. https://doi.org/10.1097/AOG.0000000000003266
Tubal Ligation and Age at Natural Menopause. / Ainsworth, Alessandra J.; Baumgarten, Sarah C.; Bakkum-Gamez, Jamie N.; Vachon, Celine M.; Weaver, Amy L.; Laughlin-Tommaso, Shannon K.
In: Obstetrics and gynecology, Vol. 133, No. 6, 01.06.2019, p. 1247-1254.
Ainsworth, AJ, Baumgarten, SC, Bakkum-Gamez, JN, Vachon, CM, Weaver, AL & Laughlin-Tommaso, SK 2019, 'Tubal Ligation and Age at Natural Menopause', Obstetrics and gynecology, vol. 133, no. 6, pp. 1247-1254. https://doi.org/10.1097/AOG.0000000000003266
Ainsworth AJ, Baumgarten SC, Bakkum-Gamez JN, Vachon CM, Weaver AL, Laughlin-Tommaso SK. Tubal Ligation and Age at Natural Menopause. Obstetrics and gynecology. 2019 Jun 1;133(6):1247-1254. https://doi.org/10.1097/AOG.0000000000003266
Ainsworth, Alessandra J. ; Baumgarten, Sarah C. ; Bakkum-Gamez, Jamie N. ; Vachon, Celine M. ; Weaver, Amy L. ; Laughlin-Tommaso, Shannon K. / Tubal Ligation and Age at Natural Menopause. In: Obstetrics and gynecology. 2019 ; Vol. 133, No. 6. pp. 1247-1254.
@article{e113021df96643f68dafb3373a6bb0c8,
title = "Tubal Ligation and Age at Natural Menopause",
abstract = "Objective: To determine the effect of tubal ligation on age at natural menopause, as a marker of long-term ovarian function. Methods: Three preexisting population-based cohorts were included in this cross-sectional study. Data from each cohort was analyzed separately. The cohorts were restricted to women who never smoked and had reached natural menopause, without prior hysterectomy or oophorectomy. The following variables were collected: race, age at menarche, age at menopause, history of hysterectomy or oophorectomy, gravidity and parity, tobacco use, and ever use of hormonal contraception. The type of tubal ligation and age at tubal ligation were manually abstracted in cohort 1. For cohorts 2 and 3, history of tubal ligation was obtained from an institutional form, completed by patient report. The primary outcome, age at natural menopause, was compared between the two groups (those with and without a history of tubal ligation). Results: Inclusion criteria was met by 555 women from cohort 1, 1,816 women from cohort 2, and 1,534 women from cohort 3. Baseline characteristics did not differ between cohorts. The percentage with tubal ligation was the same in all cohorts: 26.0%, 25.5%, and 25.0%, respectively. Women with a tubal ligation were more likely to have had at least one pregnancy and to have used hormonal contraception compared with women without a tubal ligation. There was no significant difference in age at natural menopause in women who underwent tubal ligation (50.1, 49.9, 50.0 years, respectively) compared with those who did not (50.7, 49.6, 50.0 years, respectively). The type of tubal ligation (cohort 1 only) had no effect on age at menopause. Conclusions: Tubal ligation did not affect age at natural menopause in the three large cohorts included in this study.",
author = "Ainsworth, {Alessandra J.} and Baumgarten, {Sarah C.} and Bakkum-Gamez, {Jamie N.} and Vachon, {Celine M.} and Weaver, {Amy L.} and Laughlin-Tommaso, {Shannon K.}",
note = "Funding Information: This study was made possible using the resources of the Rochester Epidemiology Project, which is supported by the National Institute on Aging of the National Institutes of Health under Award Number R01AG034676 and grant from the National Cancer Institute (R01 CA97396). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Informed consent was obtained from all subjects. Presented at the annual meeting of the American Society of Reproductive Medicine, October 6–10, 2018, Denver, Colorado. Each author has confirmed compliance with the journal{\textquoteright}s requirements for authorship. Publisher Copyright: {\textcopyright} 2019 by the American College of Obstetricians and Gynecologists.",
doi = "10.1097/AOG.0000000000003266",
journal = "Obstetrics and Gynecology",
T1 - Tubal Ligation and Age at Natural Menopause
AU - Ainsworth, Alessandra J.
AU - Baumgarten, Sarah C.
AU - Bakkum-Gamez, Jamie N.
AU - Vachon, Celine M.
AU - Weaver, Amy L.
AU - Laughlin-Tommaso, Shannon K.
N1 - Funding Information: This study was made possible using the resources of the Rochester Epidemiology Project, which is supported by the National Institute on Aging of the National Institutes of Health under Award Number R01AG034676 and grant from the National Cancer Institute (R01 CA97396). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Informed consent was obtained from all subjects. Presented at the annual meeting of the American Society of Reproductive Medicine, October 6–10, 2018, Denver, Colorado. Each author has confirmed compliance with the journal's requirements for authorship. Publisher Copyright: © 2019 by the American College of Obstetricians and Gynecologists.
N2 - Objective: To determine the effect of tubal ligation on age at natural menopause, as a marker of long-term ovarian function. Methods: Three preexisting population-based cohorts were included in this cross-sectional study. Data from each cohort was analyzed separately. The cohorts were restricted to women who never smoked and had reached natural menopause, without prior hysterectomy or oophorectomy. The following variables were collected: race, age at menarche, age at menopause, history of hysterectomy or oophorectomy, gravidity and parity, tobacco use, and ever use of hormonal contraception. The type of tubal ligation and age at tubal ligation were manually abstracted in cohort 1. For cohorts 2 and 3, history of tubal ligation was obtained from an institutional form, completed by patient report. The primary outcome, age at natural menopause, was compared between the two groups (those with and without a history of tubal ligation). Results: Inclusion criteria was met by 555 women from cohort 1, 1,816 women from cohort 2, and 1,534 women from cohort 3. Baseline characteristics did not differ between cohorts. The percentage with tubal ligation was the same in all cohorts: 26.0%, 25.5%, and 25.0%, respectively. Women with a tubal ligation were more likely to have had at least one pregnancy and to have used hormonal contraception compared with women without a tubal ligation. There was no significant difference in age at natural menopause in women who underwent tubal ligation (50.1, 49.9, 50.0 years, respectively) compared with those who did not (50.7, 49.6, 50.0 years, respectively). The type of tubal ligation (cohort 1 only) had no effect on age at menopause. Conclusions: Tubal ligation did not affect age at natural menopause in the three large cohorts included in this study.
AB - Objective: To determine the effect of tubal ligation on age at natural menopause, as a marker of long-term ovarian function. Methods: Three preexisting population-based cohorts were included in this cross-sectional study. Data from each cohort was analyzed separately. The cohorts were restricted to women who never smoked and had reached natural menopause, without prior hysterectomy or oophorectomy. The following variables were collected: race, age at menarche, age at menopause, history of hysterectomy or oophorectomy, gravidity and parity, tobacco use, and ever use of hormonal contraception. The type of tubal ligation and age at tubal ligation were manually abstracted in cohort 1. For cohorts 2 and 3, history of tubal ligation was obtained from an institutional form, completed by patient report. The primary outcome, age at natural menopause, was compared between the two groups (those with and without a history of tubal ligation). Results: Inclusion criteria was met by 555 women from cohort 1, 1,816 women from cohort 2, and 1,534 women from cohort 3. Baseline characteristics did not differ between cohorts. The percentage with tubal ligation was the same in all cohorts: 26.0%, 25.5%, and 25.0%, respectively. Women with a tubal ligation were more likely to have had at least one pregnancy and to have used hormonal contraception compared with women without a tubal ligation. There was no significant difference in age at natural menopause in women who underwent tubal ligation (50.1, 49.9, 50.0 years, respectively) compared with those who did not (50.7, 49.6, 50.0 years, respectively). The type of tubal ligation (cohort 1 only) had no effect on age at menopause. Conclusions: Tubal ligation did not affect age at natural menopause in the three large cohorts included in this study.
U2 - 10.1097/AOG.0000000000003266
DO - 10.1097/AOG.0000000000003266
JO - Obstetrics and Gynecology
JF - Obstetrics and Gynecology