Smallpox Vaccine
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A live VACCINIA VIRUS vaccine of calf lymph or chick embryo origin, used for immunization against smallpox. It is now recommended only for laboratory workers exposed to smallpox virus. Certain countries continue to vaccinate those in the military service. Complications that result from smallpox vaccination include vaccinia, secondary bacterial infections, and encephalomyelitis. (Dorland, 28th ed)
Vaccine, Smallpox
Networked: 289 relevant articles (19 outcomes, 22 trials/studies)
Drug Context: Research Results
Complex Mixtures: 485
Biological Products
Vaccines: 23992
Viral Vaccines: 180
Smallpox Vaccine: 289
imvamune: 15
DryVax vaccine: 14
smallpox vaccine LC16m8: 2
1. Damon, Inger K: 8 articles (12/2015 - 04/2005)
2. Chaplin, Paul: 7 articles (09/2015 - 02/2010)
3. Crotty, Shane: 7 articles (08/2012 - 09/2005)
4. von Krempelhuber, Alfred: 6 articles (04/2015 - 02/2010)
5. Edwards, Kathryn M: 6 articles (02/2015 - 09/2004)
6. Frey, Sharon E: 5 articles (10/2015 - 07/2009)
7. Hruby, Dennis E: 5 articles (07/2015 - 04/2008)
8. Greenberg, Richard N: 5 articles (01/2015 - 04/2008)
9. Karem, Kevin L: 5 articles (11/2012 - 05/2007)
10. Centers for Disease Control and Prevention (CDC): 5 articles (05/2009 - 02/2003)
1. Smallpox (Variola)
09/01/2004 - "The smallpox vaccine, which is highly effective in preventing the spread of both these orthopoxvirus infectious illnesses, might be administered to numerous health care workers and, in the event of a smallpox attack, millions of other citizens. "
02/05/2008 - "As a result of the successful eradication of smallpox with the vaccinia virus (VACV), the general population is no longer required to receive a smallpox vaccine, and will have no protection against smallpox. "
10/01/2005 - "The only effective treatment for smallpox is rapid administration of smallpox vaccine."
03/01/2004 - "While the disease was completely eradicated by 1980 with successful use of smallpox vaccine, concern has been raised that smallpox may emerge as a tool of bioterrorism. "
01/01/1979 - "However, it took an additional 180 years until the current smallpox vaccine--a modification of Jenner's vaccine--became fully effective, in terms of quality and usage during the global smallpox eradication campaign. "
2. Infection
02/09/2006 - "In contrast, when monkeys were vaccinated 24 h after MPXV infection, using a standard human dose of a currently recommended smallpox vaccine (Elstree-RIVM), no significant reduction in mortality was observed. "
06/01/2012 - "Smallpox vaccine provided protection against both infections. "
01/01/2014 - "In parallel, early events post-infection with the smallpox vaccine ACAM-2000 were investigated in cultured keratinocytes of human and mouse origin. "
01/01/2014 - "To focus on innate antiviral defenses in keratinocytes, we used a standard model of cutaneous infection of severe combined immunodeficient mice with the current smallpox vaccine, ACAM-2000. "
07/01/2012 - "Although there is presently no definitive evidence linking vaccinia virus transmission through reproductive cells, SART/ASRM accordingly recommends that ART practitioners consider deferring donors who have recently received smallpox vaccine or contracted symptomatic vaccinia virus infection through close contact with a vaccine recipient (until after the vaccine or infectious scab has spontaneously separated). "
3. Vaccinia
01/02/2007 - "Comparative efficacy of modified vaccinia Ankara (MVA) as a potential replacement smallpox vaccine."
11/09/2015 - "To conduct a post-marketing surveillance study of the vaccination of freeze-dried live attenuated smallpox vaccine prepared in cell culture LC16-KAKETSUKEN using attenuated vaccinia strain LC16m8. "
04/01/2015 - "The focus of this study was to compare the safety and immunogenicity of a replication-deficient, highly attenuated smallpox vaccine modified vaccinia Ankara (MVA) in HIV-infected and healthy subjects. "
04/01/2015 - "Safety and Immunogenicity of Modified Vaccinia Ankara-Bavarian Nordic Smallpox Vaccine in Vaccinia-Naive and Experienced Human Immunodeficiency Virus-Infected Individuals: An Open-Label, Controlled Clinical Phase II Trial."
03/25/2008 - "This study assessed three non-replicating smallpox vaccine candidates (modified vaccinia Ankara (MVA), NYVAC and HR) for their immunogenicity and ability to protect mice against an intranasal cowpox virus challenge and compared them with the traditional replicating vaccine. "
4. Monkeypox
03/11/2004 - "Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox."
10/01/2007 - "monkeypox outbreak of 2003, blood specimens and clinical and epidemiologic data were collected from cases, defined by standard definition, and household contacts of cases to evaluate the role of preexisting (smallpox vaccine-derived) and acquired immunity in susceptibility to monkeypox disease and clinical outcomes. "
12/15/2005 - "There are no licensed therapies for human monkeypox; however, the smallpox vaccine can protect against the disease. "
04/01/2015 - "Public health officials are also concerned about the spread of related zoonotic orthopoxviruses such as monkeypox and cowpox, against which smallpox vaccine provides protection. "
08/15/2006 - "The smallpox vaccine Dryvax, a live vaccinia virus (VACV), protects against smallpox and monkeypox, but is contraindicated in immunocompromised individuals. "
5. Communicable Diseases (Infectious Diseases)
07/01/2014 - "In response to infectious diseases, the Guangdong government established the Health Administration and institutions for infectious disease's prevention and treatment, and prepared smallpox vaccine by themselves. "
05/01/2002 - "The dictum, 'prevention is better than cure', is applicable to all ailments but it can be most easily followed for infectious diseases, increasing numbers of which are being contained by specific vaccinations since the first discovery of smallpox vaccine by Edward Jenner in 1796. "
01/01/1986 - "The gradual evolution of vaccine development from Jenner's smallpox vaccine to recombinant genetechnology has provided the basis for prophylactic control of a lot of important infectious diseases of humans and animals. "
08/01/2012 - "Smallpox vaccine is considered a gold standard of vaccines, as it is the only one that has led to the complete eradication of an infectious disease from the human population. "
06/01/2006 - "The smallpox vaccine consists of live vaccinia virus and is generally considered the gold standard of vaccines, since it is the only one that has led to the complete eradication of an infectious disease from the human population. "
1. Vaccines
2. cidofovir (Vistide)
3. Interleukin-15 (Interleukin 15)
4. Biological Markers (Surrogate Marker)
5. Measles Vaccine
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8. imvamune
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10. Hepatitis B Vaccines (Hepatitis B Vaccine)
1. Oral Administration
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4. Bone Marrow Transplantation (Transplantation, Bone Marrow)