Family aggregation of cardiovascular disease mortality: a register-based prospective study of pooled Nordic twin cohorts
Karri Silventoinen, Jacob Hjelmborg, Sören Möller, Samuli Ripatti, Axel Skytthe, Emmi Tikkanen, Nancy L Pedersen, Patrik KE Magnusson, Kaare Christensen, Jaakko Kaprio
Det Danske Tvillingregister
Epidemiologi, Biostatistik og Biodemografi
OPEN Open Patient data Explorative Network
Background: Familial factors play an important role in the variation of risk factors of cardiovascular diseases (CVD), but less is known about how they affect the risk of death from CVD. We estimated familial aggregation of CVD mortality for twins offering the maximum level of risk due to genetic and other familial factors. Methods: Altogether, 132 771 twin individuals, including 65 196 complete pairs from Denmark, Finland and Sweden born in 1958 or earlier, participated in this study. During the register-based follow-up, 11 641 deaths occurred from coronary heart disease (CHD), including 6280 deaths from myocardial infarct and 4855 deaths occurred from stroke, with 1092 deaths from ischaemic stroke and 1159 deaths from haemorrhagic stroke. Relative recurrence risk ratios (RRRs) with 95% confidence intervals (95% CIs) for monozygotic and dizygotic twins were calculated. Results: In the analyses pooling men and women, the RRR for monozygotic twins was 1.49 (95% CI 1.40-1.57) for CHD and 1.81 for any stroke (95% CI 1.54-2.09). The highest RRR was found for haemorrhagic stroke (3.53 95% CI 2.01-5.04). For dizygotic twins, the RRRs were generally lower. Conclusions: Family aggregation was found for CHD and haemorrhagic stroke. Clustering of risk factors in families increases the risk of CVD.
International Journal of Epidemiology
https://doi.org/10.1093/ije/dyx012
Udgivet - 1. jan. 2017
Dizygotic Twins
Monozygotic Twins
Silventoinen, K., Hjelmborg, J., Möller, S., Ripatti, S., Skytthe, A., Tikkanen, E., ... Kaprio, J. (2017). Family aggregation of cardiovascular disease mortality: a register-based prospective study of pooled Nordic twin cohorts. International Journal of Epidemiology, 46(4), 1223-1229. https://doi.org/10.1093/ije/dyx012
Silventoinen, Karri ; Hjelmborg, Jacob ; Möller, Sören ; Ripatti, Samuli ; Skytthe, Axel ; Tikkanen, Emmi ; Pedersen, Nancy L ; Magnusson, Patrik KE ; Christensen, Kaare ; Kaprio, Jaakko. / Family aggregation of cardiovascular disease mortality : a register-based prospective study of pooled Nordic twin cohorts. I: International Journal of Epidemiology. 2017 ; Bind 46, Nr. 4. s. 1223-1229.
@article{c136ff1310e6456c9baeea2e2e5f7f97,
title = "Family aggregation of cardiovascular disease mortality: a register-based prospective study of pooled Nordic twin cohorts",
abstract = "Background: Familial factors play an important role in the variation of risk factors of cardiovascular diseases (CVD), but less is known about how they affect the risk of death from CVD. We estimated familial aggregation of CVD mortality for twins offering the maximum level of risk due to genetic and other familial factors. Methods: Altogether, 132 771 twin individuals, including 65 196 complete pairs from Denmark, Finland and Sweden born in 1958 or earlier, participated in this study. During the register-based follow-up, 11 641 deaths occurred from coronary heart disease (CHD), including 6280 deaths from myocardial infarct and 4855 deaths occurred from stroke, with 1092 deaths from ischaemic stroke and 1159 deaths from haemorrhagic stroke. Relative recurrence risk ratios (RRRs) with 95{\%} confidence intervals (95{\%} CIs) for monozygotic and dizygotic twins were calculated. Results: In the analyses pooling men and women, the RRR for monozygotic twins was 1.49 (95{\%} CI 1.40-1.57) for CHD and 1.81 for any stroke (95{\%} CI 1.54-2.09). The highest RRR was found for haemorrhagic stroke (3.53 95{\%} CI 2.01-5.04). For dizygotic twins, the RRRs were generally lower. Conclusions: Family aggregation was found for CHD and haemorrhagic stroke. Clustering of risk factors in families increases the risk of CVD.",
keywords = "Coronary heart disease, Stroke, Genetics, Twins, Family history",
author = "Karri Silventoinen and Jacob Hjelmborg and S{\"o}ren M{\"o}ller and Samuli Ripatti and Axel Skytthe and Emmi Tikkanen and Pedersen, {Nancy L} and Magnusson, {Patrik KE} and Kaare Christensen and Jaakko Kaprio",
doi = "10.1093/ije/dyx012",
journal = "International Journal of Epidemiology",
publisher = "Heinemann",
Silventoinen, K, Hjelmborg, J, Möller, S, Ripatti, S, Skytthe, A, Tikkanen, E, Pedersen, NL, Magnusson, PKE, Christensen, K & Kaprio, J 2017, 'Family aggregation of cardiovascular disease mortality: a register-based prospective study of pooled Nordic twin cohorts', International Journal of Epidemiology, bind 46, nr. 4, s. 1223-1229. https://doi.org/10.1093/ije/dyx012
Family aggregation of cardiovascular disease mortality : a register-based prospective study of pooled Nordic twin cohorts. / Silventoinen, Karri; Hjelmborg, Jacob; Möller, Sören; Ripatti, Samuli; Skytthe, Axel; Tikkanen, Emmi; Pedersen, Nancy L; Magnusson, Patrik KE; Christensen, Kaare; Kaprio, Jaakko.
I: International Journal of Epidemiology, Bind 46, Nr. 4, 01.01.2017, s. 1223-1229.
T1 - Family aggregation of cardiovascular disease mortality
T2 - a register-based prospective study of pooled Nordic twin cohorts
AU - Silventoinen, Karri
AU - Hjelmborg, Jacob
AU - Möller, Sören
AU - Ripatti, Samuli
AU - Skytthe, Axel
AU - Tikkanen, Emmi
AU - Pedersen, Nancy L
AU - Magnusson, Patrik KE
AU - Christensen, Kaare
AU - Kaprio, Jaakko
N2 - Background: Familial factors play an important role in the variation of risk factors of cardiovascular diseases (CVD), but less is known about how they affect the risk of death from CVD. We estimated familial aggregation of CVD mortality for twins offering the maximum level of risk due to genetic and other familial factors. Methods: Altogether, 132 771 twin individuals, including 65 196 complete pairs from Denmark, Finland and Sweden born in 1958 or earlier, participated in this study. During the register-based follow-up, 11 641 deaths occurred from coronary heart disease (CHD), including 6280 deaths from myocardial infarct and 4855 deaths occurred from stroke, with 1092 deaths from ischaemic stroke and 1159 deaths from haemorrhagic stroke. Relative recurrence risk ratios (RRRs) with 95% confidence intervals (95% CIs) for monozygotic and dizygotic twins were calculated. Results: In the analyses pooling men and women, the RRR for monozygotic twins was 1.49 (95% CI 1.40-1.57) for CHD and 1.81 for any stroke (95% CI 1.54-2.09). The highest RRR was found for haemorrhagic stroke (3.53 95% CI 2.01-5.04). For dizygotic twins, the RRRs were generally lower. Conclusions: Family aggregation was found for CHD and haemorrhagic stroke. Clustering of risk factors in families increases the risk of CVD.
AB - Background: Familial factors play an important role in the variation of risk factors of cardiovascular diseases (CVD), but less is known about how they affect the risk of death from CVD. We estimated familial aggregation of CVD mortality for twins offering the maximum level of risk due to genetic and other familial factors. Methods: Altogether, 132 771 twin individuals, including 65 196 complete pairs from Denmark, Finland and Sweden born in 1958 or earlier, participated in this study. During the register-based follow-up, 11 641 deaths occurred from coronary heart disease (CHD), including 6280 deaths from myocardial infarct and 4855 deaths occurred from stroke, with 1092 deaths from ischaemic stroke and 1159 deaths from haemorrhagic stroke. Relative recurrence risk ratios (RRRs) with 95% confidence intervals (95% CIs) for monozygotic and dizygotic twins were calculated. Results: In the analyses pooling men and women, the RRR for monozygotic twins was 1.49 (95% CI 1.40-1.57) for CHD and 1.81 for any stroke (95% CI 1.54-2.09). The highest RRR was found for haemorrhagic stroke (3.53 95% CI 2.01-5.04). For dizygotic twins, the RRRs were generally lower. Conclusions: Family aggregation was found for CHD and haemorrhagic stroke. Clustering of risk factors in families increases the risk of CVD.
KW - Coronary heart disease
KW - Twins
KW - Family history
U2 - 10.1093/ije/dyx012
DO - 10.1093/ije/dyx012
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
Silventoinen K, Hjelmborg J, Möller S, Ripatti S, Skytthe A, Tikkanen E et al. Family aggregation of cardiovascular disease mortality: a register-based prospective study of pooled Nordic twin cohorts. International Journal of Epidemiology. 2017 jan 1;46(4):1223-1229. https://doi.org/10.1093/ije/dyx012
10.1093/ije/dyx012