Anti-Inflammatory and Antimicrobial Properties of Flavonoids from Heliotropium subulatum Exudate
Author(s): Bharat Singh, Institute of Biotechnology, Amity University Rajasthan, Jaipur-303 002, India. Ram A. Sharma.
Journal Name: Inflammation & Allergy - Drug Targets (Discontinued)
DOI : 10.2174/1871528114666160105113155
Graphical Abstract:
Heliotropium subulatum is an erect or procumbent perennial herb; leaves contain foliar trichomes and its resinous exudate is used in traditional medicine. The anti-inflammatory activity of dichloromethane fraction and isolated flavonoids was evaluated by using carrageenan and CFA-induced paw oedema models. Similarly, the disc diffusion and microdilution methods were used for the assessment of antimicrobial activity. Five isolated flavonoids were investigated for their antiinflammatory and antimicrobial activities. Eriodictyol demonstrated maximum anti-inflammatory activity (53.09%) at 30.0 mg/kg dose on 6th h and similarly, it inhibited the CFA-induced arthritis swelling (41.84%) with 30.0 mg/kg dose on 8th day respectively. As per disc diffusion and microdilution methods used for antimicrobial activity determination, the pinocembrin was found to be most active against Staphylococcus aureus (IZ=27±0.7 mm, 08 μg/ml dose) and Candida albicans (IZ=17±0.9 mm; 12 μg/ml dose). These investigated results revealed that the eriodictyol and pinocembrin showed significant anti-inflammatory and antimicrobial activities. Further studies which aimed to investigate the mechanism of action of these isolated flavonoids in the treatment of inflammations and various types of infections have been initiated.
Keywords: Heliotropium subulatum, anti-inflammatory and antimicrobial activity, flavonoids, carrageenan and CFA models.
Inflammation & Allergy - Drug Targets (Discontinued)
Title:Anti-Inflammatory and Antimicrobial Properties of Flavonoids from Heliotropium subulatum Exudate
Author(s):Bharat Singh and Ram A. Sharma
Affiliation:Institute of Biotechnology, Amity University Rajasthan, Jaipur-303 002, India.
Keywords:Heliotropium subulatum, anti-inflammatory and antimicrobial activity, flavonoids, carrageenan and CFA models.
Abstract:Heliotropium subulatum is an erect or procumbent perennial herb; leaves contain foliar trichomes and its resinous exudate is used in traditional medicine. The anti-inflammatory activity of dichloromethane fraction and isolated flavonoids was evaluated by using carrageenan and CFA-induced paw oedema models. Similarly, the disc diffusion and microdilution methods were used for the assessment of antimicrobial activity. Five isolated flavonoids were investigated for their antiinflammatory and antimicrobial activities. Eriodictyol demonstrated maximum anti-inflammatory activity (53.09%) at 30.0 mg/kg dose on 6th h and similarly, it inhibited the CFA-induced arthritis swelling (41.84%) with 30.0 mg/kg dose on 8th day respectively. As per disc diffusion and microdilution methods used for antimicrobial activity determination, the pinocembrin was found to be most active against Staphylococcus aureus (IZ=27±0.7 mm, 08 μg/ml dose) and Candida albicans (IZ=17±0.9 mm; 12 μg/ml dose). These investigated results revealed that the eriodictyol and pinocembrin showed significant anti-inflammatory and antimicrobial activities. Further studies which aimed to investigate the mechanism of action of these isolated flavonoids in the treatment of inflammations and various types of infections have been initiated.
Bharat Singh and Ram A. Sharma, "Anti-Inflammatory and Antimicrobial Properties of Flavonoids from Heliotropium subulatum Exudate", Inflammation & Allergy - Drug Targets (Discontinued) (2015) 14: 125. https://doi.org/10.2174/1871528114666160105113155
https://doi.org/10.2174/1871528114666160105113155 Print ISSN
DOI: 10.2174/1871528114666160105113155
Biomarkers of Atrial Fibrillation in Metabolic Syndrome
Inhibitors of ER Aminopeptidase 1 and 2: From Design to Clinical Application
Inhibitors of Secretory Phospholipase A2 Group IIA
Toxicity by NSAIDs. Counteraction by Stable Gastric Pentadecapeptide BPC 157
The Acid Sphingomyelinase/Ceramide Pathway: Biomedical Significance and Mechanisms of Regulation
A New Method for a Quantitative Determination of Piroxicam in Pharmaceutical Formulations Using FT-IR Spectrometry
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Expression and Function of Angiomodulating Cytokines in Rheumatoid Arthritis and Experimental Arthritis: Important Therapeutic Targets
Current Immunology Reviews
Micro- and Nano-particulate Strategies for Antigen Specific Immune Tolerance to Treat Autoimmune Diseases
Pharmaceutical Nanotechnology
Silencing the Transcription Factor FOSL1 in Hyperproliferative HaCaT Cells Makes Them Susceptible to IFN-γ
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry (Under Re-organization)
Novel Topical Nanocarriers for Treatment of Psoriasis: An Overview
Pharmaceutical and Histopathological Analyses of the Developing Mechanism of Severe Allergic Conjunctival Diseases Using Experimental Animal Models: Roles of Systemic and Local Cytokines
Current Pharmaceutical Analysis
Influence of Length and Amino Acid Composition on Dimer Formation of Immunoglobulin based Chimera
New Developments in the Discovery of Agents to Treat Hepatitis C
Current Topics in Medicinal Chemistry
Barrier Strengthening and Anti-inflammatory Effect of Cucurbit Fruits on Intestinal Epithelial Cells In-vitro
Current Nutrition & Food Science
M1/M2 Macrophages in Diabetic Nephropathy: Nrf2/HO-1 as Therapeutic Targets
Cardiovascular Risk Factors in Chronic Inflammatory Rheumatic Diseases: Modern Assessment and Diagnosis
Current Vascular Pharmacology
Editorial [Hot topic: Microbiota, Innate Immune and Anti-Inflammation (Guest Editor: Jun Sun)]
Targeting Cytokines, Chemokines and Adhesion Molecules in Rheumatoid Arthritis
Current Rheumatology Reviews
Statins and Cancer
Toll-Like Receptor Signaling Mechanisms Involved in Dendritic Cell Activation: Potential Therapeutic Control of T Cell Polarization