Angiotensin and Alzheimer´s disease: therapeutic prospects
Paul Gard, J.M. Rusted
This review describes the features of Alzheimer´s disease and discusses the evidence that antihypertensive therapies may be beneficial in its treatment and prevention. Drugs acting via the renin­angiotensin system are considered and it is suggested that these drugs may produce their effects via mechanisms other than by their antihypertensive actions. Using evidence from animal studies, the role of angiotensin as a neurotransmitter and its involvement in the control of normal cognitive function is described. Studies of angiotensin and human cognition are reviewed along with studies investigating the possible link between disorders of the system, either inherited or acquired, and the symptoms of Alzheimer´s disease. The therapeutic potential of screening for markers of renin­angiotensin abnormality for the prediction of Alzheimer´s disease is considered, as is the potential use of agents known to influence the renin–angiotensin system in the treatment or prevention of the disease.
Expert Review of Neurotherapeutics
https://doi.org/10.1586/14737175.4.1.87
angiotensin converting
reninangiotensin system
10.1586/14737175.4.1.87Licence: Unspecified
http://www.expert-reviews.com/doi/abs/10.1586/14737175.4.1.87Licence: Unspecified
Fingerprint Dive into the research topics of 'Angiotensin and Alzheimer´s disease: therapeutic prospects'. Together they form a unique fingerprint.
Angiotensins Medicine & Life Sciences
Neurotransmitter Agents Medicine & Life Sciences
Gard, P., & Rusted, J. M. (2004). Angiotensin and Alzheimer´s disease: therapeutic prospects. Expert Review of Neurotherapeutics, 4(1), 87-96. https://doi.org/10.1586/14737175.4.1.87
Gard, Paul ; Rusted, J.M. / Angiotensin and Alzheimer´s disease: therapeutic prospects. In: Expert Review of Neurotherapeutics. 2004 ; Vol. 4, No. 1. pp. 87-96.
@article{23fc7c30a4ac4de488fa34aa4bfa870b,
title = "Angiotensin and Alzheimer´s disease: therapeutic prospects",
abstract = "This review describes the features of Alzheimer´s disease and discusses the evidence that antihypertensive therapies may be beneficial in its treatment and prevention. Drugs acting via the renin­angiotensin system are considered and it is suggested that these drugs may produce their effects via mechanisms other than by their antihypertensive actions. Using evidence from animal studies, the role of angiotensin as a neurotransmitter and its involvement in the control of normal cognitive function is described. Studies of angiotensin and human cognition are reviewed along with studies investigating the possible link between disorders of the system, either inherited or acquired, and the symptoms of Alzheimer´s disease. The therapeutic potential of screening for markers of renin­angiotensin abnormality for the prediction of Alzheimer´s disease is considered, as is the potential use of agents known to influence the renin–angiotensin system in the treatment or prevention of the disease.",
keywords = "Alzheimer´s disease, angiotensin, angiotensin converting, antagonists, cognition, enzyme inhibitors, reninangiotensin system",
author = "Paul Gard and J.M. Rusted",
doi = "10.1586/14737175.4.1.87",
journal = "Expert Review of Neurotherapeutics",
Gard, P & Rusted, JM 2004, 'Angiotensin and Alzheimer´s disease: therapeutic prospects', Expert Review of Neurotherapeutics, vol. 4, no. 1, pp. 87-96. https://doi.org/10.1586/14737175.4.1.87
Angiotensin and Alzheimer´s disease: therapeutic prospects. / Gard, Paul; Rusted, J.M.
In: Expert Review of Neurotherapeutics, Vol. 4, No. 1, 01.2004, p. 87-96.
T1 - Angiotensin and Alzheimer´s disease: therapeutic prospects
AU - Gard, Paul
AU - Rusted, J.M.
N2 - This review describes the features of Alzheimer´s disease and discusses the evidence that antihypertensive therapies may be beneficial in its treatment and prevention. Drugs acting via the renin­angiotensin system are considered and it is suggested that these drugs may produce their effects via mechanisms other than by their antihypertensive actions. Using evidence from animal studies, the role of angiotensin as a neurotransmitter and its involvement in the control of normal cognitive function is described. Studies of angiotensin and human cognition are reviewed along with studies investigating the possible link between disorders of the system, either inherited or acquired, and the symptoms of Alzheimer´s disease. The therapeutic potential of screening for markers of renin­angiotensin abnormality for the prediction of Alzheimer´s disease is considered, as is the potential use of agents known to influence the renin–angiotensin system in the treatment or prevention of the disease.
AB - This review describes the features of Alzheimer´s disease and discusses the evidence that antihypertensive therapies may be beneficial in its treatment and prevention. Drugs acting via the renin­angiotensin system are considered and it is suggested that these drugs may produce their effects via mechanisms other than by their antihypertensive actions. Using evidence from animal studies, the role of angiotensin as a neurotransmitter and its involvement in the control of normal cognitive function is described. Studies of angiotensin and human cognition are reviewed along with studies investigating the possible link between disorders of the system, either inherited or acquired, and the symptoms of Alzheimer´s disease. The therapeutic potential of screening for markers of renin­angiotensin abnormality for the prediction of Alzheimer´s disease is considered, as is the potential use of agents known to influence the renin–angiotensin system in the treatment or prevention of the disease.
KW - Alzheimer´s disease
KW - angiotensin
KW - angiotensin converting
KW - antagonists
KW - cognition
KW - enzyme inhibitors
KW - reninangiotensin system
U2 - 10.1586/14737175.4.1.87
DO - 10.1586/14737175.4.1.87
JO - Expert Review of Neurotherapeutics
JF - Expert Review of Neurotherapeutics
Gard P, Rusted JM. Angiotensin and Alzheimer´s disease: therapeutic prospects. Expert Review of Neurotherapeutics. 2004 Jan;4(1):87-96. https://doi.org/10.1586/14737175.4.1.87