The newly described mecA homologue, mecALGA251, is present in methicillin-resistant Staphylococcus aureus isolatesfrom a diverse range of host species
GK Paterson, AR Larsen, A Robb, GE Edwards, TW Pennycott, G Foster, D Mot, K Hermans, K Baert, SJ Peacock, J Parkhill, RN Zadoks, MA Holmes
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Objectives: A previously unidentified mecA homologue, mecALGA251, has recently been described in methicillinresistant Staphylococcus aureus (MRSA) from humans and dairy cattle. The origin and epidemiology of this novel homologue are unclear. The objective of this study was to provide basic descriptive information of MRSA isolates harbouring mecALGA251 from a range of host animal species. Methods: A number of S. aureus isolates from historical animal isolate collections were chosen for investigation based on their similarity to known mecALGA251 MRSA isolates. The presence of mecALGA251 was determined using a multiplex PCR and antimicrobial susceptibility testing performed by disc diffusion. Results: MRSA harbouring mecALGA251 were found in isolates from a domestic dog, brown rats, a rabbit, a common seal, sheep and a chaffinch. All of the isolates were phenotypically MRSA, although this depended on which test was used; some isolates would be considered susceptible with certain assays. All isolates were susceptible to linezolid, rifampicin, kanamycin, norfloxacin, erythromycin, clindamycin, fusidic acid, tetracycline, trimethoprim/sulfamethoxazole and mupirocin. Five multilocus sequence types were represented (2273, 130, 425, 1764 and 1245) and six spa types (t208, t6293, t742, t6594, t7914 and t843). Conclusions: The discovery of MRSA isolates possessing mecALGA251 from a diverse range of host species, including different taxonomic classes, has important implications for the diagnosis of MRSA in these species and our understanding of the epidemiology of this novel mecA homologue.
Journal of Antimicrobial Chemotherapy
First published - 2012
Animal reservoirs
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Methicillin-Resistant Staphylococcus aureus Medicine & Life Sciences 100%
Epidemiology Medicine & Life Sciences 77%
Fusidic Acid Medicine & Life Sciences 72%
Mupirocin Medicine & Life Sciences 71%
Norfloxacin Medicine & Life Sciences 65%
Kanamycin Medicine & Life Sciences 63%
Linezolid Medicine & Life Sciences 62%
Clindamycin Medicine & Life Sciences 57%
Paterson, GK., Larsen, AR., Robb, A., Edwards, GE., Pennycott, TW., Foster, G., Mot, D., Hermans, K., Baert, K., Peacock, SJ., Parkhill, J., Zadoks, RN., & Holmes, MA. (2012). The newly described mecA homologue, mecALGA251, is present in methicillin-resistant Staphylococcus aureus isolatesfrom a diverse range of host species. Journal of Antimicrobial Chemotherapy, 67, 2809 - 2813.
Paterson, GK ; Larsen, AR ; Robb, A ; Edwards, GE ; Pennycott, TW ; Foster, G ; Mot, D ; Hermans, K ; Baert, K ; Peacock, SJ ; Parkhill, J ; Zadoks, RN ; Holmes, MA. / The newly described mecA homologue, mecALGA251, is present in methicillin-resistant Staphylococcus aureus isolatesfrom a diverse range of host species. In: Journal of Antimicrobial Chemotherapy. 2012 ; Vol. 67. pp. 2809 - 2813.
@article{651def1d215b4cbdb8a5dd7d7255d605,
title = "The newly described mecA homologue, mecALGA251, is present in methicillin-resistant Staphylococcus aureus isolatesfrom a diverse range of host species",
abstract = "Objectives: A previously unidentified mecA homologue, mecALGA251, has recently been described in methicillinresistant Staphylococcus aureus (MRSA) from humans and dairy cattle. The origin and epidemiology of this novel homologue are unclear. The objective of this study was to provide basic descriptive information of MRSA isolates harbouring mecALGA251 from a range of host animal species. Methods: A number of S. aureus isolates from historical animal isolate collections were chosen for investigation based on their similarity to known mecALGA251 MRSA isolates. The presence of mecALGA251 was determined using a multiplex PCR and antimicrobial susceptibility testing performed by disc diffusion. Results: MRSA harbouring mecALGA251 were found in isolates from a domestic dog, brown rats, a rabbit, a common seal, sheep and a chaffinch. All of the isolates were phenotypically MRSA, although this depended on which test was used; some isolates would be considered susceptible with certain assays. All isolates were susceptible to linezolid, rifampicin, kanamycin, norfloxacin, erythromycin, clindamycin, fusidic acid, tetracycline, trimethoprim/sulfamethoxazole and mupirocin. Five multilocus sequence types were represented (2273, 130, 425, 1764 and 1245) and six spa types (t208, t6293, t742, t6594, t7914 and t843). Conclusions: The discovery of MRSA isolates possessing mecALGA251 from a diverse range of host species, including different taxonomic classes, has important implications for the diagnosis of MRSA in these species and our understanding of the epidemiology of this novel mecA homologue.",
keywords = "Animal infections, Animal reservoirs",
author = "GK Paterson and AR Larsen and A Robb and GE Edwards and TW Pennycott and G Foster and D Mot and K Hermans and K Baert and SJ Peacock and J Parkhill and RN Zadoks and MA Holmes",
note = "AA115",
journal = "Journal of Antimicrobial Chemotherapy",
Paterson, GK, Larsen, AR, Robb, A, Edwards, GE, Pennycott, TW, Foster, G, Mot, D, Hermans, K, Baert, K, Peacock, SJ, Parkhill, J, Zadoks, RN & Holmes, MA 2012, 'The newly described mecA homologue, mecALGA251, is present in methicillin-resistant Staphylococcus aureus isolatesfrom a diverse range of host species', Journal of Antimicrobial Chemotherapy, vol. 67, pp. 2809 - 2813.
The newly described mecA homologue, mecALGA251, is present in methicillin-resistant Staphylococcus aureus isolatesfrom a diverse range of host species. / Paterson, GK; Larsen, AR; Robb, A; Edwards, GE; Pennycott, TW; Foster, G; Mot, D; Hermans, K; Baert, K; Peacock, SJ; Parkhill, J; Zadoks, RN; Holmes, MA.
In: Journal of Antimicrobial Chemotherapy, Vol. 67, 2012, p. 2809 - 2813.
T1 - The newly described mecA homologue, mecALGA251, is present in methicillin-resistant Staphylococcus aureus isolatesfrom a diverse range of host species
AU - Paterson, GK
AU - Larsen, AR
AU - Robb, A
AU - Edwards, GE
AU - Pennycott, TW
AU - Foster, G
AU - Mot, D
AU - Hermans, K
AU - Baert, K
AU - Peacock, SJ
AU - Parkhill, J
AU - Zadoks, RN
AU - Holmes, MA
N1 - AA115
N2 - Objectives: A previously unidentified mecA homologue, mecALGA251, has recently been described in methicillinresistant Staphylococcus aureus (MRSA) from humans and dairy cattle. The origin and epidemiology of this novel homologue are unclear. The objective of this study was to provide basic descriptive information of MRSA isolates harbouring mecALGA251 from a range of host animal species. Methods: A number of S. aureus isolates from historical animal isolate collections were chosen for investigation based on their similarity to known mecALGA251 MRSA isolates. The presence of mecALGA251 was determined using a multiplex PCR and antimicrobial susceptibility testing performed by disc diffusion. Results: MRSA harbouring mecALGA251 were found in isolates from a domestic dog, brown rats, a rabbit, a common seal, sheep and a chaffinch. All of the isolates were phenotypically MRSA, although this depended on which test was used; some isolates would be considered susceptible with certain assays. All isolates were susceptible to linezolid, rifampicin, kanamycin, norfloxacin, erythromycin, clindamycin, fusidic acid, tetracycline, trimethoprim/sulfamethoxazole and mupirocin. Five multilocus sequence types were represented (2273, 130, 425, 1764 and 1245) and six spa types (t208, t6293, t742, t6594, t7914 and t843). Conclusions: The discovery of MRSA isolates possessing mecALGA251 from a diverse range of host species, including different taxonomic classes, has important implications for the diagnosis of MRSA in these species and our understanding of the epidemiology of this novel mecA homologue.
AB - Objectives: A previously unidentified mecA homologue, mecALGA251, has recently been described in methicillinresistant Staphylococcus aureus (MRSA) from humans and dairy cattle. The origin and epidemiology of this novel homologue are unclear. The objective of this study was to provide basic descriptive information of MRSA isolates harbouring mecALGA251 from a range of host animal species. Methods: A number of S. aureus isolates from historical animal isolate collections were chosen for investigation based on their similarity to known mecALGA251 MRSA isolates. The presence of mecALGA251 was determined using a multiplex PCR and antimicrobial susceptibility testing performed by disc diffusion. Results: MRSA harbouring mecALGA251 were found in isolates from a domestic dog, brown rats, a rabbit, a common seal, sheep and a chaffinch. All of the isolates were phenotypically MRSA, although this depended on which test was used; some isolates would be considered susceptible with certain assays. All isolates were susceptible to linezolid, rifampicin, kanamycin, norfloxacin, erythromycin, clindamycin, fusidic acid, tetracycline, trimethoprim/sulfamethoxazole and mupirocin. Five multilocus sequence types were represented (2273, 130, 425, 1764 and 1245) and six spa types (t208, t6293, t742, t6594, t7914 and t843). Conclusions: The discovery of MRSA isolates possessing mecALGA251 from a diverse range of host species, including different taxonomic classes, has important implications for the diagnosis of MRSA in these species and our understanding of the epidemiology of this novel mecA homologue.
KW - Animal infections
KW - Animal reservoirs
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
Paterson GK, Larsen AR, Robb A, Edwards GE, Pennycott TW, Foster G et al. The newly described mecA homologue, mecALGA251, is present in methicillin-resistant Staphylococcus aureus isolatesfrom a diverse range of host species. Journal of Antimicrobial Chemotherapy. 2012;67:2809 - 2813.