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Gastrointestinal Symptoms in a Sample of Children with Pervasive Developmental Disorders
Auteurs: Roumen N. Nikolov, Karen E. Bearss, Jelle Lettinga, Craig Erickson, Maria Rodowski, Michael G. Aman, James T. McCracken, Christopher J. McDougle, Elaine Tierney, Benedetto Vitiello, L. Eugene Arnold, Bhavik Shah, David J. Posey, Louise Ritz, Lawrence Scahill
Objective To evaluate gastrointestinal (GI) problems in a large, well-characterized sample of children with pervasive developmental disorders (PDDs). Methods One hundred seventy two children entering one of two trials conducted by the Research Units on Pediatric Psychopharmacology (RUPP) Autism Network were assessed comprehensively prior to starting treatment and classified with regard to GI symptoms. Results Thirty nine (22.7%) were positive for GI problems, primarily constipation and diarrhea. Those with GI problems were no different from subjects without GI problems in demographic characteristics, measures of adaptive functioning, or autism symptom severity. Compared to children without GI problems, those with GI problems showed greater symptom severity on measures of irritability, anxiety, and social withdrawal. Those with GI problems were also less likely to respond to treatment.
vorige artikel Positive Effects of Methylphenidate on Social Communication and Self-Regulation in Children with Pervasive Developmental Disorders and Hyperactivity
volgende artikel Using the Autism Diagnostic Interview-Revised and the Autism Diagnostic Observation Schedule-Generic for the Diagnosis of Autism Spectrum Disorders in a Greek Sample with a Wide Range of Intellectual Abilities
go back to reference Afzal, N., Murch, S., Thirrupathy, K., Berger, L., Fagbemi, A., & Heuschkel, R. (2003). Constipation with acquired megarectum in children with autism. Pediatrics, 112, 939–942. doi: 10.​1542/​peds.​112.​4.​939. PubMedCrossRef Afzal, N., Murch, S., Thirrupathy, K., Berger, L., Fagbemi, A., & Heuschkel, R. (2003). Constipation with acquired megarectum in children with autism. Pediatrics, 112, 939–942. doi: 10.​1542/​peds.​112.​4.​939. PubMedCrossRef
go back to reference Aman, M. G., Singh, N. N., Stewart, A. W., & Field, C. J. (1985). Psychometric characteristics of the Aberrant Behavior Checklist. American Journal of Mental Deficiency, 89, 492–502. PubMed Aman, M. G., Singh, N. N., Stewart, A. W., & Field, C. J. (1985). Psychometric characteristics of the Aberrant Behavior Checklist. American Journal of Mental Deficiency, 89, 492–502. PubMed
go back to reference American Psychiatric Association. (2000). Diagnostic and Statistical Manual of Mental Disorders, Text revision (4th ed.). Washington, DC: American Psychiatric Association. American Psychiatric Association. (2000). Diagnostic and Statistical Manual of Mental Disorders, Text revision (4th ed.). Washington, DC: American Psychiatric Association.
go back to reference Arnold, L. E., Aman, M. G., Martin, A., Collier-Crespin, A., Vitiello, B., Tierney, E., et al. (2000). Assessment in multisite randomized clinical trials of patients with autistic disorder: The Autism RUPP Network Research Units on Pediatric Psychopharmacology. Journal of Autism and Developmental Disorders, 30, 99–111. doi: 10.​1023/​A:​1005451304303. PubMedCrossRef Arnold, L. E., Aman, M. G., Martin, A., Collier-Crespin, A., Vitiello, B., Tierney, E., et al. (2000). Assessment in multisite randomized clinical trials of patients with autistic disorder: The Autism RUPP Network Research Units on Pediatric Psychopharmacology. Journal of Autism and Developmental Disorders, 30, 99–111. doi: 10.​1023/​A:​1005451304303. PubMedCrossRef
go back to reference Autism Genome Project Consortium. (2007). Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nature Genetics, 39, 319–328. doi: 10.​1038/​ng1985. CrossRef Autism Genome Project Consortium. (2007). Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nature Genetics, 39, 319–328. doi: 10.​1038/​ng1985. CrossRef
go back to reference Balzola, F., Barbon, V., Repici, A., & Rizzetto, M. (2005). Panenteric IBD-like disease in a patient with regressive autism shown for the first time by the wireless capsule enteroscopy: Another piece in the jigsaw of this gut-brain syndrome? The American Journal of Gastroenterology, 100(4), 979–980. doi: 10.​1111/​j.​1572-0241.​2005.​41202_​4.​x. PubMedCrossRef Balzola, F., Barbon, V., Repici, A., & Rizzetto, M. (2005). Panenteric IBD-like disease in a patient with regressive autism shown for the first time by the wireless capsule enteroscopy: Another piece in the jigsaw of this gut-brain syndrome? The American Journal of Gastroenterology, 100(4), 979–980. doi: 10.​1111/​j.​1572-0241.​2005.​41202_​4.​x. PubMedCrossRef
go back to reference Black, C., Kaye, J. A., & Jick, H. (2002). Relation of childhood gastrointestinal disorders to autism: nested case-control study using data from the UK General Practice Research Database. BMJ (Clinical Research Ed.), 325, 419–421. doi: 10.​1136/​bmj.​325.​7361.​419. CrossRef Black, C., Kaye, J. A., & Jick, H. (2002). Relation of childhood gastrointestinal disorders to autism: nested case-control study using data from the UK General Practice Research Database. BMJ (Clinical Research Ed.), 325, 419–421. doi: 10.​1136/​bmj.​325.​7361.​419. CrossRef
go back to reference Brinkley, J., Nations, L., Abramson, R. K., Hall, A., Wright, H. H., Gabriels, R., et al. (2007). Factor analysis of the Aberrant Behavior Checklist in individuals with autism spectrum disorder. Journal of Autism and Developmental Disorders, 37, 1949–1959. doi: 10.​1007/​s10803-006-0327-3. PubMedCrossRef Brinkley, J., Nations, L., Abramson, R. K., Hall, A., Wright, H. H., Gabriels, R., et al. (2007). Factor analysis of the Aberrant Behavior Checklist in individuals with autism spectrum disorder. Journal of Autism and Developmental Disorders, 37, 1949–1959. doi: 10.​1007/​s10803-006-0327-3. PubMedCrossRef
go back to reference Brown, E. C., Aman, M. G., & Havercamp, S. M. (2002). Factor analysis and norms for parent ratings on the Aberrant Behavior Checklist-Community for young people in special education. Research in Developmental Disabilities, 23, 45–60. doi: 10.​1016/​S0891-4222(01)00091-9. PubMedCrossRef Brown, E. C., Aman, M. G., & Havercamp, S. M. (2002). Factor analysis and norms for parent ratings on the Aberrant Behavior Checklist-Community for young people in special education. Research in Developmental Disabilities, 23, 45–60. doi: 10.​1016/​S0891-4222(01)00091-9. PubMedCrossRef
go back to reference D'Eufemia, P., Celli, M., Finocchiaro, R., Pacifico, L., Viozzi, L., Zaccagnini, M., et al. (1996). Abnormal intestinal permeability in children with autism. Acta Paediatrica (Oslo, Norway), 85, 1076–1079. doi: 10.​1111/​j.​1651-2227.​1996.​tb14220.​x. CrossRef D'Eufemia, P., Celli, M., Finocchiaro, R., Pacifico, L., Viozzi, L., Zaccagnini, M., et al. (1996). Abnormal intestinal permeability in children with autism. Acta Paediatrica (Oslo, Norway), 85, 1076–1079. doi: 10.​1111/​j.​1651-2227.​1996.​tb14220.​x. CrossRef
go back to reference Erickson, C. A., Stigler, K. A., Corkins, M. R., Posey, D. J., Fitzgerald, J. F., & McDougle, C. J. (2005). Gastrointestinal factors in autistic disorder: A critical review. Journal of Autism and Developmental Disorders, 35, 713–727. doi: 10.​1007/​s10803-005-0019-4. PubMedCrossRef Erickson, C. A., Stigler, K. A., Corkins, M. R., Posey, D. J., Fitzgerald, J. F., & McDougle, C. J. (2005). Gastrointestinal factors in autistic disorder: A critical review. Journal of Autism and Developmental Disorders, 35, 713–727. doi: 10.​1007/​s10803-005-0019-4. PubMedCrossRef
go back to reference Fombonne, E. (2005). Epidemiology of autistic disorder and other pervasive developmental disorders. The Journal of Clinical Psychiatry, 66(Suppl), 3–8. PubMed Fombonne, E. (2005). Epidemiology of autistic disorder and other pervasive developmental disorders. The Journal of Clinical Psychiatry, 66(Suppl), 3–8. PubMed
go back to reference Fombonne, E., & Chakrabarti, S. (2001). No evidence for a new variant of measles-mumps-rubella-induced autism. Pediatrics, 108, E58. doi: 10.​1542/​peds.​108.​4.​e58. PubMedCrossRef Fombonne, E., & Chakrabarti, S. (2001). No evidence for a new variant of measles-mumps-rubella-induced autism. Pediatrics, 108, E58. doi: 10.​1542/​peds.​108.​4.​e58. PubMedCrossRef
go back to reference Fombonne, E., Zakarian, R., Bennett, A., Meng, L., & McLean-Heywood, D. (2006). Pervasive developmental disorders in Montreal, Quebac, Canada: Prevalence and links with Immunization. Pediatrics, 118, 139–150. CrossRef Fombonne, E., Zakarian, R., Bennett, A., Meng, L., & McLean-Heywood, D. (2006). Pervasive developmental disorders in Montreal, Quebac, Canada: Prevalence and links with Immunization. Pediatrics, 118, 139–150. CrossRef
go back to reference Gupta, A. R., & State, M. W. (2007). Recent advances in the genetics of autism. Biological Psychiatry, 61, 429–437. doi: 10.​1016/​j.​biopsych.​2006.​06.​020. PubMedCrossRef Gupta, A. R., & State, M. W. (2007). Recent advances in the genetics of autism. Biological Psychiatry, 61, 429–437. doi: 10.​1016/​j.​biopsych.​2006.​06.​020. PubMedCrossRef
go back to reference Herbert, M. R., Russo, J. P., Yang, S., Roohi, J., Blaxill, M., Kahler, S. G., et al. (2006). Autism and environmental genomics. Neurotoxicology, 27, 671–684. doi: 10.​1016/​j.​neuro.​2006.​03.​017. PubMedCrossRef Herbert, M. R., Russo, J. P., Yang, S., Roohi, J., Blaxill, M., Kahler, S. G., et al. (2006). Autism and environmental genomics. Neurotoxicology, 27, 671–684. doi: 10.​1016/​j.​neuro.​2006.​03.​017. PubMedCrossRef
go back to reference Horvath, K., Papadimitriou, J. C., Rabsztyn, A., Drachenberg, C., & Tildon, J. T. (1999). Gastrointestinal abnormalities in children with autistic disorder. The Journal of Pediatrics, 135, 559–563. doi: 10.​1016/​S0022-3476(99)70052-1. PubMedCrossRef Horvath, K., Papadimitriou, J. C., Rabsztyn, A., Drachenberg, C., & Tildon, J. T. (1999). Gastrointestinal abnormalities in children with autistic disorder. The Journal of Pediatrics, 135, 559–563. doi: 10.​1016/​S0022-3476(99)70052-1. PubMedCrossRef
go back to reference Horvath, K., & Perman, J. A. (2002a). Autism and gastrointestinal symptoms. Current Gastroenterology Reports, 4, 251–258. doi: 10.​1007/​s11894-002-0071-6. PubMedCrossRef Horvath, K., & Perman, J. A. (2002a). Autism and gastrointestinal symptoms. Current Gastroenterology Reports, 4, 251–258. doi: 10.​1007/​s11894-002-0071-6. PubMedCrossRef
go back to reference Horvath, K., & Perman, J. A. (2002b). Autistic disorder and gastrointestinal disease. Current Opinion in Pediatrics, 14, 583–587. doi: 10.​1097/​00008480-200210000-00004. PubMedCrossRef Horvath, K., & Perman, J. A. (2002b). Autistic disorder and gastrointestinal disease. Current Opinion in Pediatrics, 14, 583–587. doi: 10.​1097/​00008480-200210000-00004. PubMedCrossRef
go back to reference Jensen, J. A., & Armstrong, R. J. (1985). Slosson intelligence test for children and adults. East Aurora, NY: Slosson Educational Publications. Jensen, J. A., & Armstrong, R. J. (1985). Slosson intelligence test for children and adults. East Aurora, NY: Slosson Educational Publications.
go back to reference Knivsberg, A. M., Reichelt, K. L., Nodland, N., & Hoien, T. (1995). Autistic syndrome and diet: A follow-up study. Scandinavian Journal of Educational Research, 39, 223–236. doi: 10.​1080/​0031383950390304​. CrossRef Knivsberg, A. M., Reichelt, K. L., Nodland, N., & Hoien, T. (1995). Autistic syndrome and diet: A follow-up study. Scandinavian Journal of Educational Research, 39, 223–236. doi: 10.​1080/​0031383950390304​. CrossRef
go back to reference Kuddo, T., & Nelson, K. B. (2003). How common are gastrointestinal disorders in children with autism? Current Opinion in Pediatrics, 15, 339–343. doi: 10.​1097/​00008480-200306000-00020. PubMedCrossRef Kuddo, T., & Nelson, K. B. (2003). How common are gastrointestinal disorders in children with autism? Current Opinion in Pediatrics, 15, 339–343. doi: 10.​1097/​00008480-200306000-00020. PubMedCrossRef
go back to reference Lawler, C. P., Croen, L. A., Grether, J. K., & Van de Water, J. (2004). Identifying environmental contributions to autism: provocative clues and false leads. Mental Retardation and Developmental Disabilities Research Reviews, 10, 292–302. doi: 10.​1002/​mrdd.​20043. PubMedCrossRef Lawler, C. P., Croen, L. A., Grether, J. K., & Van de Water, J. (2004). Identifying environmental contributions to autism: provocative clues and false leads. Mental Retardation and Developmental Disabilities Research Reviews, 10, 292–302. doi: 10.​1002/​mrdd.​20043. PubMedCrossRef
go back to reference Lecavalier, L., Aman, M. G., Scahill, L., McDougle, C. J., McCracken, J. T., Vitiello, B., et al. (2006). Validity of the autism diagnostic interview-revised. American Journal of Mental Retardation, 111, 199–215. doi: 10.​1352/​0895-8017(2006)111[199:​VOTADI]2.​0.​CO;2. PubMedCrossRef Lecavalier, L., Aman, M. G., Scahill, L., McDougle, C. J., McCracken, J. T., Vitiello, B., et al. (2006). Validity of the autism diagnostic interview-revised. American Journal of Mental Retardation, 111, 199–215. doi: 10.​1352/​0895-8017(2006)111[199:​VOTADI]2.​0.​CO;2. PubMedCrossRef
go back to reference Levy, S. E., Souders, M. C., Ittenbach, R. F., Giarelli, E., Mulberg, A. E., & Pinto-Martin, J. A. (2007). Relationship of dietary intake to gastrointestinal symptoms in children with autistic spectrum disorders. Biological Psychiatry, 61, 492–497. doi: 10.​1016/​j.​biopsych.​2006.​07.​013. PubMedCrossRef Levy, S. E., Souders, M. C., Ittenbach, R. F., Giarelli, E., Mulberg, A. E., & Pinto-Martin, J. A. (2007). Relationship of dietary intake to gastrointestinal symptoms in children with autistic spectrum disorders. Biological Psychiatry, 61, 492–497. doi: 10.​1016/​j.​biopsych.​2006.​07.​013. PubMedCrossRef
go back to reference Lord, C., Pickles, A., McLennan, J., Rutter, M., Bregman, J., Folstein, S., et al. (1997). Diagnosing autism: Analyses of data from the Autism Diagnostic Interview. Journal of Autism and Developmental Disorders, 27, 501–517. doi: 10.​1023/​A:​1025873925661. PubMedCrossRef Lord, C., Pickles, A., McLennan, J., Rutter, M., Bregman, J., Folstein, S., et al. (1997). Diagnosing autism: Analyses of data from the Autism Diagnostic Interview. Journal of Autism and Developmental Disorders, 27, 501–517. doi: 10.​1023/​A:​1025873925661. PubMedCrossRef
go back to reference Lucarelli, S., Frediani, T., Zingoni, A. M., Ferruzzi, F., Giardini, O., Quintieri, F., et al. (1995). Food allergy and infantile autism. Panminerva Medica, 37, 137–141. PubMed Lucarelli, S., Frediani, T., Zingoni, A. M., Ferruzzi, F., Giardini, O., Quintieri, F., et al. (1995). Food allergy and infantile autism. Panminerva Medica, 37, 137–141. PubMed
go back to reference Molloy, C. A., & Manning-Courtney, P. (2003). Prevalence of chronic gastrointestinal symptoms in children with autism and autistic spectrum disorders. Autism, 7, 165–171. doi: 10.​1177/​1362361303007002​004. PubMedCrossRef Molloy, C. A., & Manning-Courtney, P. (2003). Prevalence of chronic gastrointestinal symptoms in children with autism and autistic spectrum disorders. Autism, 7, 165–171. doi: 10.​1177/​1362361303007002​004. PubMedCrossRef
go back to reference Mullen, E. (1995). The Mullen scales of early learning. Circle Pines, MN: American Guidance Service. Mullen, E. (1995). The Mullen scales of early learning. Circle Pines, MN: American Guidance Service.
go back to reference Mussel, M., Kroenke, K., Spitzer, R. L., Williams, J. B., Herzog, W., & Löwe, B. (2008). Gastrointestinal symptoms in primary care: Prevalence and association with depression and anxiety. Journal of Psychosomatic Research, 64, 605–612. doi: 10.​1016/​j.​jpsychores.​2008.​02.​019. CrossRef Mussel, M., Kroenke, K., Spitzer, R. L., Williams, J. B., Herzog, W., & Löwe, B. (2008). Gastrointestinal symptoms in primary care: Prevalence and association with depression and anxiety. Journal of Psychosomatic Research, 64, 605–612. doi: 10.​1016/​j.​jpsychores.​2008.​02.​019. CrossRef
go back to reference Research Units on Pediatric Psychopharmacology (RUPP) Autism Network. (2002). Risperidone in children with autism and serious behavioral problems. The New England Journal of Medicine, 347, 314–321. doi: 10.​1056/​NEJMoa013171. CrossRef Research Units on Pediatric Psychopharmacology (RUPP) Autism Network. (2002). Risperidone in children with autism and serious behavioral problems. The New England Journal of Medicine, 347, 314–321. doi: 10.​1056/​NEJMoa013171. CrossRef
go back to reference Research Units on Pediatric Psychopharmacology (RUPP) Autism Network. (2005a). Randomized, controlled, crossover trial of methylphenidate in children with pervasive developmental disorders with hyperactivity. Archives of General Psychiatry, 62, 1266–1274. doi: 10.​1001/​archpsyc.​62.​11.​1266. CrossRef Research Units on Pediatric Psychopharmacology (RUPP) Autism Network. (2005a). Randomized, controlled, crossover trial of methylphenidate in children with pervasive developmental disorders with hyperactivity. Archives of General Psychiatry, 62, 1266–1274. doi: 10.​1001/​archpsyc.​62.​11.​1266. CrossRef
go back to reference Research Units on Pediatric Psychopharmacology (RUPP) Autism Network. (2005b). Risperidone treatment of autistic disorder: Longer term benefits and blinded discontinuation after six months. American Journal of Psychiatry, 162, 1361–1369. Research Units on Pediatric Psychopharmacology (RUPP) Autism Network. (2005b). Risperidone treatment of autistic disorder: Longer term benefits and blinded discontinuation after six months. American Journal of Psychiatry, 162, 1361–1369.
go back to reference Roid, G. H., & Miller, L. J. (1997). Leiter international performance scale-revised: Examiner's manual. Wood Dale, IL: Stoelting Co. Roid, G. H., & Miller, L. J. (1997). Leiter international performance scale-revised: Examiner's manual. Wood Dale, IL: Stoelting Co.
go back to reference Saps, M., Sztainberg, M., & Di Lorenzo, C. (2006). A prospective community-based study of gastroenterological symptoms in school-age children. Journal of Pediatric Gastroenterology and Nutrition, 43, 477–482. doi: 10.​1097/​01.​mpg.​0000235979.​41947.​f6. PubMedCrossRef Saps, M., Sztainberg, M., & Di Lorenzo, C. (2006). A prospective community-based study of gastroenterological symptoms in school-age children. Journal of Pediatric Gastroenterology and Nutrition, 43, 477–482. doi: 10.​1097/​01.​mpg.​0000235979.​41947.​f6. PubMedCrossRef
go back to reference Scahill, L. (2005). Diagnosis and evaluation of pervasive developmental disorders. The Journal of Clinical Psychiatry, 66(Suppl), 19–25. PubMed Scahill, L. (2005). Diagnosis and evaluation of pervasive developmental disorders. The Journal of Clinical Psychiatry, 66(Suppl), 19–25. PubMed
go back to reference Scahill, L., McDougle, C. J., Williams, S. K., Dimitropoulos, A., Aman, M. G., McCracken, J. T., et al. (2006). Children's Yale-Brown Obsessive Compulsive Scale modified for pervasive developmental disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 45, 1114–1123. doi: 10.​1097/​01.​chi.​0000220854.​79144.​e7. PubMedCrossRef Scahill, L., McDougle, C. J., Williams, S. K., Dimitropoulos, A., Aman, M. G., McCracken, J. T., et al. (2006). Children's Yale-Brown Obsessive Compulsive Scale modified for pervasive developmental disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 45, 1114–1123. doi: 10.​1097/​01.​chi.​0000220854.​79144.​e7. PubMedCrossRef
go back to reference Sparrow, S., Balla, D., & Cicchetti, D. (1984). Vineland Adaptive Behavior Scales. Circle Pines, MN: American Guidance Service. Sparrow, S., Balla, D., & Cicchetti, D. (1984). Vineland Adaptive Behavior Scales. Circle Pines, MN: American Guidance Service.
go back to reference Sukhodolsky, D.G., Scahill, L., Gadow, K.D., Arnold, L.E., Aman, M.G., McDougle, C.J., et al. (2007). Parent-rated anxiety symptoms in children with pervasive developmental disorders: Frequency and association with core autism symptoms and cognitive functioning. Journal of Abnormal Child Psychology; Epub ahead of print. Sukhodolsky, D.G., Scahill, L., Gadow, K.D., Arnold, L.E., Aman, M.G., McDougle, C.J., et al. (2007). Parent-rated anxiety symptoms in children with pervasive developmental disorders: Frequency and association with core autism symptoms and cognitive functioning. Journal of Abnormal Child Psychology; Epub ahead of print.
go back to reference Taylor, B., Miller, E., Lingam, R., Andrews, N., Simmons, A., & Stowe, J. (2002). Measles, mumps and rubella vaccination and bowel problems or developmental regression in children with autism: Population study. British Medical Journal, 324, 393–396. doi: 10.​1136/​bmj.​324.​7334.​393. PubMedCrossRef Taylor, B., Miller, E., Lingam, R., Andrews, N., Simmons, A., & Stowe, J. (2002). Measles, mumps and rubella vaccination and bowel problems or developmental regression in children with autism: Population study. British Medical Journal, 324, 393–396. doi: 10.​1136/​bmj.​324.​7334.​393. PubMedCrossRef
go back to reference Valicenti-McDermott, M., McVicar, K., Rapin, I., Wershil, B. K., Cohen, H., & Shinnar, S. (2006). Frequency of gastrointestinal symptoms in children with autistic spectrum disorders and association with family history of autoimmune disease. Journal of Developmental and Behavioral Pediatrics, 27, S128–S136. doi: 10.​1097/​00004703-200604002-00011. PubMedCrossRef Valicenti-McDermott, M., McVicar, K., Rapin, I., Wershil, B. K., Cohen, H., & Shinnar, S. (2006). Frequency of gastrointestinal symptoms in children with autistic spectrum disorders and association with family history of autoimmune disease. Journal of Developmental and Behavioral Pediatrics, 27, S128–S136. doi: 10.​1097/​00004703-200604002-00011. PubMedCrossRef
go back to reference Wakefield, A. J., Anthony, A., Murch, S. H., Thomson, M. A., Montgomery, S. M., Davies, S., et al. (2000). Enterocolitis in children with developmental disorders. The American Journal of Gastroenterology, 95, 2285–2295. doi: 10.​1111/​j.​1572-0241.​2000.​03248.​x. PubMedCrossRef Wakefield, A. J., Anthony, A., Murch, S. H., Thomson, M. A., Montgomery, S. M., Davies, S., et al. (2000). Enterocolitis in children with developmental disorders. The American Journal of Gastroenterology, 95, 2285–2295. doi: 10.​1111/​j.​1572-0241.​2000.​03248.​x. PubMedCrossRef
go back to reference Wechsler, D. (1989). Manual for the Wechsler preschool and primary scale for children—revised. San Antonio, TX: Psychological Corporation. Wechsler, D. (1989). Manual for the Wechsler preschool and primary scale for children—revised. San Antonio, TX: Psychological Corporation.
go back to reference Wechsler, D. (1991). Manual for the Wechsler intelligence scale for children—Third edition. San Antonio, TX: Psychological Corporation. Wechsler, D. (1991). Manual for the Wechsler intelligence scale for children—Third edition. San Antonio, TX: Psychological Corporation.
Roumen N. Nikolov
Karen E. Bearss
Jelle Lettinga
Maria Rodowski
Michael G. Aman
James T. McCracken
Christopher J. McDougle
Elaine Tierney
Benedetto Vitiello
L. Eugene Arnold
Bhavik Shah
David J. Posey
Louise Ritz
Lawrence Scahill
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