Pulse transit time measured by photoplethysmography improves the accuracy of heart rate as a surrogate measure of cardiac output, stroke volume and oxygen uptake in response to graded exercise
L. Pollonini, N. S. Padhye, R. Re, A. Torricelli, R. J. Simpson, C. C. Dacso
Heart rate (HR) is a valuable and widespread measure for physical training programs, although its description of conditioning is limited to the cardiac response to exercise. More comprehensive measures of exercise adaptation include cardiac output (Q), stroke volume (SV) and oxygen uptake (VO2), but these physiological parameters can be measured only with cumbersome equipment installed in clinical settings. In this work, we explore the ability of pulse transit time (PTT) to represent a valuable pairing with HR for indirectly estimating Q, SV and VO2 non-invasively. PTT was measured as the time interval between the peak of the electrocardiographic (ECG) R-wave and the onset of the photoplethysmography (PPG) waveform at the periphery (i.e. fingertip) with a portable sensor. Fifteen healthy young subjects underwent a graded incremental cycling protocol after which HR and PTT were correlated with Q, SV and VO2 using linear mixed models. The addition of PTT significantly improved the modeling of Q, SV and VO2 at the individual level (R12 = 0.419 for SV, 0.548 for Q, and 0.771 for VO2) compared to predictive models based solely on HR (R12 = 0.379 for SV, 0.503 for Q, and 0.745 for VO2). While challenges in sensitivity and artifact rejection exist, combining PTT with HR holds potential for development of novel wearable sensors that provide exercise assessment largely superior to HR monitors.
Physiological Measurement
https://doi.org/10.1088/0967-3334/36/5/911
oxygen uptake
pulse transit time
stroke volume
10.1088/0967-3334/36/5/911
Dive into the research topics of 'Pulse transit time measured by photoplethysmography improves the accuracy of heart rate as a surrogate measure of cardiac output, stroke volume and oxygen uptake in response to graded exercise'. Together they form a unique fingerprint.
Vanadium dioxide Engineering & Materials Science 100%
Pulse Wave Analysis Medicine & Life Sciences 76%
Cardiac Output Medicine & Life Sciences 61%
Oxygen Engineering & Materials Science 51%
Heart Rate Medicine & Life Sciences 46%
Exercise Medicine & Life Sciences 41%
Pollonini, L., Padhye, N. S., Re, R., Torricelli, A., Simpson, R. J., & Dacso, C. C. (2015). Pulse transit time measured by photoplethysmography improves the accuracy of heart rate as a surrogate measure of cardiac output, stroke volume and oxygen uptake in response to graded exercise. Physiological Measurement, 36(5), 911-924. [911]. https://doi.org/10.1088/0967-3334/36/5/911
Pulse transit time measured by photoplethysmography improves the accuracy of heart rate as a surrogate measure of cardiac output, stroke volume and oxygen uptake in response to graded exercise. / Pollonini, L.; Padhye, N. S.; Re, R.; Torricelli, A.; Simpson, R. J.; Dacso, C. C.
In: Physiological Measurement, Vol. 36, No. 5, 911, 01.05.2015, p. 911-924.
Pollonini, L, Padhye, NS, Re, R, Torricelli, A, Simpson, RJ & Dacso, CC 2015, 'Pulse transit time measured by photoplethysmography improves the accuracy of heart rate as a surrogate measure of cardiac output, stroke volume and oxygen uptake in response to graded exercise', Physiological Measurement, vol. 36, no. 5, 911, pp. 911-924. https://doi.org/10.1088/0967-3334/36/5/911
Pollonini L, Padhye NS, Re R, Torricelli A, Simpson RJ, Dacso CC. Pulse transit time measured by photoplethysmography improves the accuracy of heart rate as a surrogate measure of cardiac output, stroke volume and oxygen uptake in response to graded exercise. Physiological Measurement. 2015 May 1;36(5):911-924. 911. https://doi.org/10.1088/0967-3334/36/5/911
Pollonini, L. ; Padhye, N. S. ; Re, R. ; Torricelli, A. ; Simpson, R. J. ; Dacso, C. C. / Pulse transit time measured by photoplethysmography improves the accuracy of heart rate as a surrogate measure of cardiac output, stroke volume and oxygen uptake in response to graded exercise. In: Physiological Measurement. 2015 ; Vol. 36, No. 5. pp. 911-924.
@article{9f3ecefc914242b3b47307f20e3780ea,
title = "Pulse transit time measured by photoplethysmography improves the accuracy of heart rate as a surrogate measure of cardiac output, stroke volume and oxygen uptake in response to graded exercise",
abstract = "Heart rate (HR) is a valuable and widespread measure for physical training programs, although its description of conditioning is limited to the cardiac response to exercise. More comprehensive measures of exercise adaptation include cardiac output (Q), stroke volume (SV) and oxygen uptake (VO2), but these physiological parameters can be measured only with cumbersome equipment installed in clinical settings. In this work, we explore the ability of pulse transit time (PTT) to represent a valuable pairing with HR for indirectly estimating Q, SV and VO2 non-invasively. PTT was measured as the time interval between the peak of the electrocardiographic (ECG) R-wave and the onset of the photoplethysmography (PPG) waveform at the periphery (i.e. fingertip) with a portable sensor. Fifteen healthy young subjects underwent a graded incremental cycling protocol after which HR and PTT were correlated with Q, SV and VO2 using linear mixed models. The addition of PTT significantly improved the modeling of Q, SV and VO2 at the individual level (R12 = 0.419 for SV, 0.548 for Q, and 0.771 for VO2) compared to predictive models based solely on HR (R12 = 0.379 for SV, 0.503 for Q, and 0.745 for VO2). While challenges in sensitivity and artifact rejection exist, combining PTT with HR holds potential for development of novel wearable sensors that provide exercise assessment largely superior to HR monitors.",
keywords = "cardiac output, oxygen uptake, photoplethysmography, pulse transit time, stroke volume",
author = "L. Pollonini and Padhye, {N. S.} and R. Re and A. Torricelli and Simpson, {R. J.} and Dacso, {C. C.}",
note = "Publisher Copyright: {\textcopyright} 2015 Institute of Physics and Engineering in Medicine.",
doi = "10.1088/0967-3334/36/5/911",
journal = "Clinical Physics and Physiological Measurement",
T1 - Pulse transit time measured by photoplethysmography improves the accuracy of heart rate as a surrogate measure of cardiac output, stroke volume and oxygen uptake in response to graded exercise
AU - Pollonini, L.
AU - Padhye, N. S.
AU - Re, R.
AU - Torricelli, A.
AU - Simpson, R. J.
AU - Dacso, C. C.
N1 - Publisher Copyright: © 2015 Institute of Physics and Engineering in Medicine.
N2 - Heart rate (HR) is a valuable and widespread measure for physical training programs, although its description of conditioning is limited to the cardiac response to exercise. More comprehensive measures of exercise adaptation include cardiac output (Q), stroke volume (SV) and oxygen uptake (VO2), but these physiological parameters can be measured only with cumbersome equipment installed in clinical settings. In this work, we explore the ability of pulse transit time (PTT) to represent a valuable pairing with HR for indirectly estimating Q, SV and VO2 non-invasively. PTT was measured as the time interval between the peak of the electrocardiographic (ECG) R-wave and the onset of the photoplethysmography (PPG) waveform at the periphery (i.e. fingertip) with a portable sensor. Fifteen healthy young subjects underwent a graded incremental cycling protocol after which HR and PTT were correlated with Q, SV and VO2 using linear mixed models. The addition of PTT significantly improved the modeling of Q, SV and VO2 at the individual level (R12 = 0.419 for SV, 0.548 for Q, and 0.771 for VO2) compared to predictive models based solely on HR (R12 = 0.379 for SV, 0.503 for Q, and 0.745 for VO2). While challenges in sensitivity and artifact rejection exist, combining PTT with HR holds potential for development of novel wearable sensors that provide exercise assessment largely superior to HR monitors.
AB - Heart rate (HR) is a valuable and widespread measure for physical training programs, although its description of conditioning is limited to the cardiac response to exercise. More comprehensive measures of exercise adaptation include cardiac output (Q), stroke volume (SV) and oxygen uptake (VO2), but these physiological parameters can be measured only with cumbersome equipment installed in clinical settings. In this work, we explore the ability of pulse transit time (PTT) to represent a valuable pairing with HR for indirectly estimating Q, SV and VO2 non-invasively. PTT was measured as the time interval between the peak of the electrocardiographic (ECG) R-wave and the onset of the photoplethysmography (PPG) waveform at the periphery (i.e. fingertip) with a portable sensor. Fifteen healthy young subjects underwent a graded incremental cycling protocol after which HR and PTT were correlated with Q, SV and VO2 using linear mixed models. The addition of PTT significantly improved the modeling of Q, SV and VO2 at the individual level (R12 = 0.419 for SV, 0.548 for Q, and 0.771 for VO2) compared to predictive models based solely on HR (R12 = 0.379 for SV, 0.503 for Q, and 0.745 for VO2). While challenges in sensitivity and artifact rejection exist, combining PTT with HR holds potential for development of novel wearable sensors that provide exercise assessment largely superior to HR monitors.
KW - cardiac output
KW - oxygen uptake
KW - photoplethysmography
KW - pulse transit time
KW - stroke volume
U2 - 10.1088/0967-3334/36/5/911
DO - 10.1088/0967-3334/36/5/911
JO - Clinical Physics and Physiological Measurement
JF - Clinical Physics and Physiological Measurement
M1 - 911