Opportunities and challenges when using record linkage of routinely collected electronic health care data to evaluate outcomes of systemic anti-cancer treatment in clinical practice
Tanja Mueller*, Jennifer Laskey, Kelly Baillie, Julie Clarke, Christine Crearie, Kimberley Kavanagh, Janet Graham, Kathryn Graham, Ashita Waterson, Robert Jones, Amanj Kurdi, David Morrison, Marion Bennie
The efficacy and safety of cancer medicines as reported from randomised clinical trials do not always translate into similar benefits in routine clinical practice; hence, post-marketing studies are a useful addition to the evidence base. With recent advances in digital infrastructure and the advent of electronically available health records, linkage of routinely collected data has emerged as a promising evaluation method for these studies. This paper discusses the opportunities and challenges when applying an electronic record linkage methodology with respect to systemic anti-cancer therapy by showcasing exemplar studies conducted over a three-year period in Scotland, and highlights some of the potential pitfalls spanning the entire breadth and depth of the research process. Our experiences as an interdisciplinary team indicate that there is scope to conduct large cohort studies to generate results from routine clinical practice within a reasonable time frame; however, close collaboration between researchers, data controllers and clinicians is required in order to obtain valid and meaningful results.
Health Informatics Journal
record linkage
Dive into the research topics of 'Opportunities and challenges when using record linkage of routinely collected electronic health care data to evaluate outcomes of systemic anti-cancer treatment in clinical practice'. Together they form a unique fingerprint.
Delivery of Health Care Medicine & Life Sciences 100%
Marketing Medicine & Life Sciences 89%
Evaluation Studies Medicine & Life Sciences 73%
Mueller, T., Laskey, J., Baillie, K., Clarke, J., Crearie, C., Kavanagh, K., Graham, J., Graham, K., Waterson, A., Jones, R., Kurdi, A., Morrison, D., & Bennie, M. (2022). Opportunities and challenges when using record linkage of routinely collected electronic health care data to evaluate outcomes of systemic anti-cancer treatment in clinical practice. Health Informatics Journal, 28(1). https://doi.org/10.1177/14604582221077055
Mueller, Tanja ; Laskey, Jennifer ; Baillie, Kelly et al. / Opportunities and challenges when using record linkage of routinely collected electronic health care data to evaluate outcomes of systemic anti-cancer treatment in clinical practice. In: Health Informatics Journal. 2022 ; Vol. 28, No. 1.
@article{deee72647e5f4225917c47612e9819ea,
title = "Opportunities and challenges when using record linkage of routinely collected electronic health care data to evaluate outcomes of systemic anti-cancer treatment in clinical practice",
abstract = "The efficacy and safety of cancer medicines as reported from randomised clinical trials do not always translate into similar benefits in routine clinical practice; hence, post-marketing studies are a useful addition to the evidence base. With recent advances in digital infrastructure and the advent of electronically available health records, linkage of routinely collected data has emerged as a promising evaluation method for these studies. This paper discusses the opportunities and challenges when applying an electronic record linkage methodology with respect to systemic anti-cancer therapy by showcasing exemplar studies conducted over a three-year period in Scotland, and highlights some of the potential pitfalls spanning the entire breadth and depth of the research process. Our experiences as an interdisciplinary team indicate that there is scope to conduct large cohort studies to generate results from routine clinical practice within a reasonable time frame; however, close collaboration between researchers, data controllers and clinicians is required in order to obtain valid and meaningful results.",
keywords = "Cancer, clinical practice, record linkage, treatment outcomes",
author = "Tanja Mueller and Jennifer Laskey and Kelly Baillie and Julie Clarke and Christine Crearie and Kimberley Kavanagh and Janet Graham and Kathryn Graham and Ashita Waterson and Robert Jones and Amanj Kurdi and David Morrison and Marion Bennie",
note = "Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Scottish Government. The funder has no role in the study design, data collection, data analyses, or interpretation of data; or in the preparation or review of manuscripts for publication. Publisher Copyright: {\textcopyright} The Author(s) 2022.",
journal = "Health Informatics Journal",
publisher = "SAGE Publications Ltd",
Mueller, T, Laskey, J, Baillie, K, Clarke, J, Crearie, C, Kavanagh, K, Graham, J, Graham, K, Waterson, A, Jones, R, Kurdi, A, Morrison, D & Bennie, M 2022, 'Opportunities and challenges when using record linkage of routinely collected electronic health care data to evaluate outcomes of systemic anti-cancer treatment in clinical practice', Health Informatics Journal, vol. 28, no. 1. https://doi.org/10.1177/14604582221077055
Opportunities and challenges when using record linkage of routinely collected electronic health care data to evaluate outcomes of systemic anti-cancer treatment in clinical practice. / Mueller, Tanja; Laskey, Jennifer; Baillie, Kelly et al.
In: Health Informatics Journal, Vol. 28, No. 1, 07.02.2022.
T1 - Opportunities and challenges when using record linkage of routinely collected electronic health care data to evaluate outcomes of systemic anti-cancer treatment in clinical practice
AU - Mueller, Tanja
AU - Laskey, Jennifer
AU - Baillie, Kelly
AU - Clarke, Julie
AU - Crearie, Christine
AU - Kavanagh, Kimberley
AU - Graham, Janet
AU - Graham, Kathryn
AU - Waterson, Ashita
AU - Jones, Robert
AU - Kurdi, Amanj
AU - Morrison, David
AU - Bennie, Marion
N1 - Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Scottish Government. The funder has no role in the study design, data collection, data analyses, or interpretation of data; or in the preparation or review of manuscripts for publication. Publisher Copyright: © The Author(s) 2022.
N2 - The efficacy and safety of cancer medicines as reported from randomised clinical trials do not always translate into similar benefits in routine clinical practice; hence, post-marketing studies are a useful addition to the evidence base. With recent advances in digital infrastructure and the advent of electronically available health records, linkage of routinely collected data has emerged as a promising evaluation method for these studies. This paper discusses the opportunities and challenges when applying an electronic record linkage methodology with respect to systemic anti-cancer therapy by showcasing exemplar studies conducted over a three-year period in Scotland, and highlights some of the potential pitfalls spanning the entire breadth and depth of the research process. Our experiences as an interdisciplinary team indicate that there is scope to conduct large cohort studies to generate results from routine clinical practice within a reasonable time frame; however, close collaboration between researchers, data controllers and clinicians is required in order to obtain valid and meaningful results.
AB - The efficacy and safety of cancer medicines as reported from randomised clinical trials do not always translate into similar benefits in routine clinical practice; hence, post-marketing studies are a useful addition to the evidence base. With recent advances in digital infrastructure and the advent of electronically available health records, linkage of routinely collected data has emerged as a promising evaluation method for these studies. This paper discusses the opportunities and challenges when applying an electronic record linkage methodology with respect to systemic anti-cancer therapy by showcasing exemplar studies conducted over a three-year period in Scotland, and highlights some of the potential pitfalls spanning the entire breadth and depth of the research process. Our experiences as an interdisciplinary team indicate that there is scope to conduct large cohort studies to generate results from routine clinical practice within a reasonable time frame; however, close collaboration between researchers, data controllers and clinicians is required in order to obtain valid and meaningful results.
KW - clinical practice
KW - record linkage
KW - treatment outcomes
JO - Health Informatics Journal
JF - Health Informatics Journal
Mueller T, Laskey J, Baillie K, Clarke J, Crearie C, Kavanagh K et al. Opportunities and challenges when using record linkage of routinely collected electronic health care data to evaluate outcomes of systemic anti-cancer treatment in clinical practice. Health Informatics Journal. 2022 Feb 7;28(1). doi: 10.1177/14604582221077055