Pathophysiological insights into the cardiomyopathy of Chagas' disease
S. A. Morris, H. B. Tanowitz, M. Wittner, J. P. Bilezikian
The evidence gained from both human and animal studies of chronic chagasic cardiomyopathy suggests that the disease occurs as a consequence of several discrete and progressive pathophysiological processes occurring after infection, thge ultimate expression of which depends on a host of unidentified factors. Collectively, the infection-associated events compromise microvasculature function and result in hypoperfusion, with consequences indistinguishable from those observed in other, nonparasitological cardiomyopathic diseases secondary to hypoperfusion. Therefore, chronic chagasic cardiomyopathy may share similar pathophysiological abnormalities with other chronic congestive cardiomyopathic states.
https://doi.org/10.1161/01.CIR.82.6.1900
Chagas' disease
Trypanosoma cruzi
microcirculation
10.1161/01.CIR.82.6.1900
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Chagas Disease Medicine & Life Sciences 100%
Cardiomyopathies Medicine & Life Sciences 81%
Microvessels Medicine & Life Sciences 42%
Morris, S. A., Tanowitz, H. B., Wittner, M., & Bilezikian, J. P. (1990). Pathophysiological insights into the cardiomyopathy of Chagas' disease. Circulation, 82(6), 1900-1909. https://doi.org/10.1161/01.CIR.82.6.1900
Pathophysiological insights into the cardiomyopathy of Chagas' disease. / Morris, S. A.; Tanowitz, H. B.; Wittner, M. et al.
In: Circulation, Vol. 82, No. 6, 1990, p. 1900-1909.
Morris, SA, Tanowitz, HB, Wittner, M & Bilezikian, JP 1990, 'Pathophysiological insights into the cardiomyopathy of Chagas' disease', Circulation, vol. 82, no. 6, pp. 1900-1909. https://doi.org/10.1161/01.CIR.82.6.1900
Morris SA, Tanowitz HB, Wittner M, Bilezikian JP. Pathophysiological insights into the cardiomyopathy of Chagas' disease. Circulation. 1990;82(6):1900-1909. doi: 10.1161/01.CIR.82.6.1900
Morris, S. A. ; Tanowitz, H. B. ; Wittner, M. et al. / Pathophysiological insights into the cardiomyopathy of Chagas' disease. In: Circulation. 1990 ; Vol. 82, No. 6. pp. 1900-1909.
@article{bd80e0871ac9449fb5b1cd07ae6b56c3,
title = "Pathophysiological insights into the cardiomyopathy of Chagas' disease",
abstract = "The evidence gained from both human and animal studies of chronic chagasic cardiomyopathy suggests that the disease occurs as a consequence of several discrete and progressive pathophysiological processes occurring after infection, thge ultimate expression of which depends on a host of unidentified factors. Collectively, the infection-associated events compromise microvasculature function and result in hypoperfusion, with consequences indistinguishable from those observed in other, nonparasitological cardiomyopathic diseases secondary to hypoperfusion. Therefore, chronic chagasic cardiomyopathy may share similar pathophysiological abnormalities with other chronic congestive cardiomyopathic states.",
keywords = "Chagas' disease, Trypanosoma cruzi, cardiomyopathy, microcirculation",
author = "Morris, {S. A.} and Tanowitz, {H. B.} and M. Wittner and Bilezikian, {J. P.}",
doi = "10.1161/01.CIR.82.6.1900",
journal = "Circulation",
T1 - Pathophysiological insights into the cardiomyopathy of Chagas' disease
AU - Morris, S. A.
AU - Tanowitz, H. B.
AU - Wittner, M.
AU - Bilezikian, J. P.
N2 - The evidence gained from both human and animal studies of chronic chagasic cardiomyopathy suggests that the disease occurs as a consequence of several discrete and progressive pathophysiological processes occurring after infection, thge ultimate expression of which depends on a host of unidentified factors. Collectively, the infection-associated events compromise microvasculature function and result in hypoperfusion, with consequences indistinguishable from those observed in other, nonparasitological cardiomyopathic diseases secondary to hypoperfusion. Therefore, chronic chagasic cardiomyopathy may share similar pathophysiological abnormalities with other chronic congestive cardiomyopathic states.
AB - The evidence gained from both human and animal studies of chronic chagasic cardiomyopathy suggests that the disease occurs as a consequence of several discrete and progressive pathophysiological processes occurring after infection, thge ultimate expression of which depends on a host of unidentified factors. Collectively, the infection-associated events compromise microvasculature function and result in hypoperfusion, with consequences indistinguishable from those observed in other, nonparasitological cardiomyopathic diseases secondary to hypoperfusion. Therefore, chronic chagasic cardiomyopathy may share similar pathophysiological abnormalities with other chronic congestive cardiomyopathic states.
KW - Chagas' disease
KW - Trypanosoma cruzi
KW - cardiomyopathy
KW - microcirculation
U2 - 10.1161/01.CIR.82.6.1900
DO - 10.1161/01.CIR.82.6.1900
JO - Circulation
JF - Circulation