The Association of Single Nucleotide Polymorphism Rs6548238 in TMEM18 Gene with Obesity in Hanoi Primary School Children
Le Thi Tuyet, Duong Thi Anh Dao
TUYET, Le Thi; DAO, Duong Thi Anh. The Association of Single Nucleotide Polymorphism Rs6548238 in TMEM18 Gene with Obesity in Hanoi Primary School Children. VNU Journal of Science: Medical and Pharmaceutical Sciences, [S.l.], v. 34, n. 1, june 2018. ISSN 2588-1132. Available at: <https://js.vnu.edu.vn/MPS/article/view/4109>. Date accessed: 27 jan. 2023. doi: https://doi.org/10.25073/2588-1132/vnumps.4109.
The transmembrane 18 gene (TMEM18) has been found associating with obesity risk in European, Chinese, and Japanese descents. However, the contribution of TMEM18 gene to obesity in the Vietnamese population has not been fully described. The purpose of the present study is to evaluate the association of rs6548238 TMEM18 gene with obesity in Hanoi primary school children. A case-control study was conducted on 559 children aged 6-11 (278 obese cases and 281 normal controls). The nutrition status of the children was classified using both the criteria of International Obesity Task Force 2000 and World Health Organization 2007. The results showed that the prevalence of risk allele (allele C) was higher in obese group than that in normal group (0.964 vs. 0.939, P=0.056). After adjusting for age, sex, there was an association between SNP rs6548238 and obesity in the children of the recessive model (the children with CC genotype had 1.8 times higher risk of obesity than the children with TT and CT genotypes) and of the additive (per allele C) model (one allele C increased the risk of obesity by 1.7 times).
Obesity, children, TMEM18 gene, rs6548238.
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