Micro Total Analysis Systems: Microfluidic aspects, integration concept and applications
Albert van den Berg, Theodorus S.J. Lammerink
Research output: Chapter in Book/Report/Conference proceeding › Chapter › Academic
In this contribution three aspects of miniaturized total analysis systems (µTAS) are described and discussed in detail. First, an overview of microfabricated components for fluid handling is given. A description of the importance of sampling- and fluid-handling techniques is followed by details of microvalves, micropumps and micro flowchannels. Secondly, the problems associated with system integration are discussed. As a solution for the realization of microfluidic- and micro analysis systems, the concept of a planar mixed circuit board (MCB) as a platform for the integration of different components is described. In addition, the design, modeling and simulation, and realization of several components in the form of standard modules for integration on a MCB is described. As an illustration of the potential of this approach, the realization of a µTAS demonstrator for the optical detection of the pH change of a pH indicator, is presented. Finally, a number of different applications of µTAS are described, such as on-line process monitoring, environmental monitoring, biomedical and space applications and DNA-analysis.
Topics in Current Chemestry
https://doi.org/10.1007/3-540-69544-3_2
Microsystem - (bio)chemical analysis - fluid handling - µTAS - micropump
van den Berg, A., & Lammerink, T. S. J. (1997). Micro Total Analysis Systems: Microfluidic aspects, integration concept and applications. In Topics in Current Chemestry (pp. 21-49). Berlin: Springer. https://doi.org/10.1007/3-540-69544-3_2
van den Berg, Albert ; Lammerink, Theodorus S.J. / Micro Total Analysis Systems: Microfluidic aspects, integration concept and applications. Topics in Current Chemestry. Berlin : Springer, 1997. pp. 21-49
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title = "Micro Total Analysis Systems: Microfluidic aspects, integration concept and applications",
abstract = "In this contribution three aspects of miniaturized total analysis systems (µTAS) are described and discussed in detail. First, an overview of microfabricated components for fluid handling is given. A description of the importance of sampling- and fluid-handling techniques is followed by details of microvalves, micropumps and micro flowchannels. Secondly, the problems associated with system integration are discussed. As a solution for the realization of microfluidic- and micro analysis systems, the concept of a planar mixed circuit board (MCB) as a platform for the integration of different components is described. In addition, the design, modeling and simulation, and realization of several components in the form of standard modules for integration on a MCB is described. As an illustration of the potential of this approach, the realization of a µTAS demonstrator for the optical detection of the pH change of a pH indicator, is presented. Finally, a number of different applications of µTAS are described, such as on-line process monitoring, environmental monitoring, biomedical and space applications and DNA-analysis.",
keywords = "METIS-112475, Microsystem - (bio)chemical analysis - fluid handling - µTAS - micropump, IR-15593",
author = "{van den Berg}, Albert and Lammerink, {Theodorus S.J.}",
note = "Topics in Current Chemistry 194",
doi = "10.1007/3-540-69544-3_2",
booktitle = "Topics in Current Chemestry",
van den Berg, A & Lammerink, TSJ 1997, Micro Total Analysis Systems: Microfluidic aspects, integration concept and applications. in Topics in Current Chemestry. Springer, Berlin, pp. 21-49. https://doi.org/10.1007/3-540-69544-3_2
Micro Total Analysis Systems: Microfluidic aspects, integration concept and applications. / van den Berg, Albert; Lammerink, Theodorus S.J.
Topics in Current Chemestry. Berlin : Springer, 1997. p. 21-49.
T1 - Micro Total Analysis Systems: Microfluidic aspects, integration concept and applications
AU - van den Berg, Albert
AU - Lammerink, Theodorus S.J.
N1 - Topics in Current Chemistry 194
N2 - In this contribution three aspects of miniaturized total analysis systems (µTAS) are described and discussed in detail. First, an overview of microfabricated components for fluid handling is given. A description of the importance of sampling- and fluid-handling techniques is followed by details of microvalves, micropumps and micro flowchannels. Secondly, the problems associated with system integration are discussed. As a solution for the realization of microfluidic- and micro analysis systems, the concept of a planar mixed circuit board (MCB) as a platform for the integration of different components is described. In addition, the design, modeling and simulation, and realization of several components in the form of standard modules for integration on a MCB is described. As an illustration of the potential of this approach, the realization of a µTAS demonstrator for the optical detection of the pH change of a pH indicator, is presented. Finally, a number of different applications of µTAS are described, such as on-line process monitoring, environmental monitoring, biomedical and space applications and DNA-analysis.
AB - In this contribution three aspects of miniaturized total analysis systems (µTAS) are described and discussed in detail. First, an overview of microfabricated components for fluid handling is given. A description of the importance of sampling- and fluid-handling techniques is followed by details of microvalves, micropumps and micro flowchannels. Secondly, the problems associated with system integration are discussed. As a solution for the realization of microfluidic- and micro analysis systems, the concept of a planar mixed circuit board (MCB) as a platform for the integration of different components is described. In addition, the design, modeling and simulation, and realization of several components in the form of standard modules for integration on a MCB is described. As an illustration of the potential of this approach, the realization of a µTAS demonstrator for the optical detection of the pH change of a pH indicator, is presented. Finally, a number of different applications of µTAS are described, such as on-line process monitoring, environmental monitoring, biomedical and space applications and DNA-analysis.
KW - Microsystem - (bio)chemical analysis - fluid handling - µTAS - micropump
U2 - 10.1007/3-540-69544-3_2
DO - 10.1007/3-540-69544-3_2
BT - Topics in Current Chemestry
CY - Berlin
van den Berg A, Lammerink TSJ. Micro Total Analysis Systems: Microfluidic aspects, integration concept and applications. In Topics in Current Chemestry. Berlin: Springer. 1997. p. 21-49 https://doi.org/10.1007/3-540-69544-3_2
10.1007/3-540-69544-3_2
Berg97micro