Delocalization of Vg1 mRNA from the vegetal cortex in Xenopus oocytes after destruction of Xlsirt RNA
Malgorzata Kloc, Laurence D. Etkin
Immunobiology & Transplant Science Center
J.C. Walter Jr. Transplant Center
The Xlsirts are a family of transcribed repeat sequence genes that do not code for protein. Xlsirt RNAs become localized to the vegetal cortex of Xenopus oocytes early in oogenesis, before the localization of the messenger RNA Vg1, which encodes a transforming growth factor-β-like molecule involved in mesoderm formation, and coincident with the localization of Xcat2 transcripts, which encode a nanos-like molecule. Destruction of the localized Xlsirts by injection of antisense oligodeoxynucleotides into stage 4 oocytes resulted in the release of Vg1 transcripts but not Xcat2 transcripts from the vegetal cortex. Xlsirt RNAs, which may be a structural component of the vegetal cortex, are a crucial part of a genetic pathway necessary for the proper localization of Vg1 that leads to subsequent normal pattern formation.
https://doi.org/10.1126/science.7520603
10.1126/science.7520603
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Xenopus Medicine & Life Sciences 100%
Oocytes Medicine & Life Sciences 88%
RNA Medicine & Life Sciences 65%
Oogenesis Medicine & Life Sciences 63%
Oligodeoxyribonucleotides Medicine & Life Sciences 57%
Transforming Growth Factors Medicine & Life Sciences 49%
Kloc, M., & Etkin, L. D. (1994). Delocalization of Vg1 mRNA from the vegetal cortex in Xenopus oocytes after destruction of Xlsirt RNA. Science, 265(5175), 1101-1103. https://doi.org/10.1126/science.7520603
Delocalization of Vg1 mRNA from the vegetal cortex in Xenopus oocytes after destruction of Xlsirt RNA. / Kloc, Malgorzata; Etkin, Laurence D.
In: Science, Vol. 265, No. 5175, 1994, p. 1101-1103.
Kloc, M & Etkin, LD 1994, 'Delocalization of Vg1 mRNA from the vegetal cortex in Xenopus oocytes after destruction of Xlsirt RNA', Science, vol. 265, no. 5175, pp. 1101-1103. https://doi.org/10.1126/science.7520603
Kloc M, Etkin LD. Delocalization of Vg1 mRNA from the vegetal cortex in Xenopus oocytes after destruction of Xlsirt RNA. Science. 1994;265(5175):1101-1103. https://doi.org/10.1126/science.7520603
Kloc, Malgorzata ; Etkin, Laurence D. / Delocalization of Vg1 mRNA from the vegetal cortex in Xenopus oocytes after destruction of Xlsirt RNA. In: Science. 1994 ; Vol. 265, No. 5175. pp. 1101-1103.
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title = "Delocalization of Vg1 mRNA from the vegetal cortex in Xenopus oocytes after destruction of Xlsirt RNA",
abstract = "The Xlsirts are a family of transcribed repeat sequence genes that do not code for protein. Xlsirt RNAs become localized to the vegetal cortex of Xenopus oocytes early in oogenesis, before the localization of the messenger RNA Vg1, which encodes a transforming growth factor-β-like molecule involved in mesoderm formation, and coincident with the localization of Xcat2 transcripts, which encode a nanos-like molecule. Destruction of the localized Xlsirts by injection of antisense oligodeoxynucleotides into stage 4 oocytes resulted in the release of Vg1 transcripts but not Xcat2 transcripts from the vegetal cortex. Xlsirt RNAs, which may be a structural component of the vegetal cortex, are a crucial part of a genetic pathway necessary for the proper localization of Vg1 that leads to subsequent normal pattern formation.",
author = "Malgorzata Kloc and Etkin, {Laurence D.}",
doi = "10.1126/science.7520603",
journal = "Science (New York, N.Y.)",
publisher = "American Association for the Advancement of Science",
T1 - Delocalization of Vg1 mRNA from the vegetal cortex in Xenopus oocytes after destruction of Xlsirt RNA
AU - Kloc, Malgorzata
AU - Etkin, Laurence D.
N2 - The Xlsirts are a family of transcribed repeat sequence genes that do not code for protein. Xlsirt RNAs become localized to the vegetal cortex of Xenopus oocytes early in oogenesis, before the localization of the messenger RNA Vg1, which encodes a transforming growth factor-β-like molecule involved in mesoderm formation, and coincident with the localization of Xcat2 transcripts, which encode a nanos-like molecule. Destruction of the localized Xlsirts by injection of antisense oligodeoxynucleotides into stage 4 oocytes resulted in the release of Vg1 transcripts but not Xcat2 transcripts from the vegetal cortex. Xlsirt RNAs, which may be a structural component of the vegetal cortex, are a crucial part of a genetic pathway necessary for the proper localization of Vg1 that leads to subsequent normal pattern formation.
AB - The Xlsirts are a family of transcribed repeat sequence genes that do not code for protein. Xlsirt RNAs become localized to the vegetal cortex of Xenopus oocytes early in oogenesis, before the localization of the messenger RNA Vg1, which encodes a transforming growth factor-β-like molecule involved in mesoderm formation, and coincident with the localization of Xcat2 transcripts, which encode a nanos-like molecule. Destruction of the localized Xlsirts by injection of antisense oligodeoxynucleotides into stage 4 oocytes resulted in the release of Vg1 transcripts but not Xcat2 transcripts from the vegetal cortex. Xlsirt RNAs, which may be a structural component of the vegetal cortex, are a crucial part of a genetic pathway necessary for the proper localization of Vg1 that leads to subsequent normal pattern formation.
U2 - 10.1126/science.7520603
DO - 10.1126/science.7520603
JO - Science (New York, N.Y.)
JF - Science (New York, N.Y.)