Chronic pain in medullary sponge kidney: a rare and never described clinical presentation
G. Gambaro, D. S. Goldfarb, R. Baccaro, J. Hirsch, N. Topilow, S. D'Alonzo, G. Gambassi, P. M. Ferraro
IRCCS Fondazione Policlinico Universitario A. Gemelli
Medullary sponge kidney (MSK) is a cause of nephrocalcinosis, associated with hematuria, renal colic, pyelonephritis. There are rare and atypical MSK cases characterized by chronic severe pain (CP), whose features are unknown, in particular the relationship with the stone disease activity. This study analyzes a cohort of MSK–CP patients belonging to three North-America self-support Facebook groups. Patients had to self-administer an on-line questionnaire (on intensity, progression and MSK-associated conditions, stone-related disease, pain features, drug use), the Brief Pain Inventory, the Fatigue Severity Score, and Wisconsin Quality of Life (WQL) in stone formers questionnaires. Ninety-two patients with a diagnosis of MSK joined our survey. Stone rate was very high (3.1 stones per patient-year, < 15% of patients had ≤ 1 stone per year). Most patients had repeated hospitalizations for stones symptoms (p < 0.001) or pain (p < 0.005). 71% of participants referred a daily pain that interfered strongly with everyday life and quality of life (WQL mean value 29.4). 69% used pain medications daily (70% opioids). In most cases, pain was associated with stone passage, while 15% referred a sine materia pain. We showed how MSK–CP symptoms affect very negatively on the quality of life of these patients. They also have a definite risk of progressing to end-stage kidney disease. Generally, CP seems to be associated with an exceptionally high lithogenic activity, suggesting that a better and earlier metabolic treatment for stone prevention should be the first approach in these patients before mini-invasive treatments to prevent pain.
Journal of Nephrology
Published - Aug 1 2018
Medullary sponge kidney
Nephrolitiasis
Renal colic
Renal stones
Dive into the research topics of 'Chronic pain in medullary sponge kidney: a rare and never described clinical presentation'. Together they form a unique fingerprint.
Medullary Sponge Kidney Medicine & Life Sciences 100%
Chronic Pain Medicine & Life Sciences 52%
Pain Medicine & Life Sciences 33%
Quality of Life Medicine & Life Sciences 27%
Nephrocalcinosis Medicine & Life Sciences 10%
Renal Colic Medicine & Life Sciences 10%
Pyelonephritis Medicine & Life Sciences 8%
North America Medicine & Life Sciences 7%
Gambaro, G., Goldfarb, D. S., Baccaro, R., Hirsch, J., Topilow, N., D'Alonzo, S., Gambassi, G., & Ferraro, P. M. (2018). Chronic pain in medullary sponge kidney: a rare and never described clinical presentation. Journal of Nephrology, 31(4), 537-542. https://doi.org/10.1007/s40620-018-0480-8
Chronic pain in medullary sponge kidney : a rare and never described clinical presentation. / Gambaro, G.; Goldfarb, D. S.; Baccaro, R.; Hirsch, J.; Topilow, N.; D'Alonzo, S.; Gambassi, G.; Ferraro, P. M.
In: Journal of Nephrology, Vol. 31, No. 4, 01.08.2018, p. 537-542.
Gambaro, G, Goldfarb, DS, Baccaro, R, Hirsch, J, Topilow, N, D'Alonzo, S, Gambassi, G & Ferraro, PM 2018, 'Chronic pain in medullary sponge kidney: a rare and never described clinical presentation', Journal of Nephrology, vol. 31, no. 4, pp. 537-542. https://doi.org/10.1007/s40620-018-0480-8
Gambaro G, Goldfarb DS, Baccaro R, Hirsch J, Topilow N, D'Alonzo S et al. Chronic pain in medullary sponge kidney: a rare and never described clinical presentation. Journal of Nephrology. 2018 Aug 1;31(4):537-542. https://doi.org/10.1007/s40620-018-0480-8
Gambaro, G. ; Goldfarb, D. S. ; Baccaro, R. ; Hirsch, J. ; Topilow, N. ; D'Alonzo, S. ; Gambassi, G. ; Ferraro, P. M. / Chronic pain in medullary sponge kidney : a rare and never described clinical presentation. In: Journal of Nephrology. 2018 ; Vol. 31, No. 4. pp. 537-542.
@article{f643d82c25a9496db4d1758101b06b01,
title = "Chronic pain in medullary sponge kidney: a rare and never described clinical presentation",
abstract = "Medullary sponge kidney (MSK) is a cause of nephrocalcinosis, associated with hematuria, renal colic, pyelonephritis. There are rare and atypical MSK cases characterized by chronic severe pain (CP), whose features are unknown, in particular the relationship with the stone disease activity. This study analyzes a cohort of MSK–CP patients belonging to three North-America self-support Facebook groups. Patients had to self-administer an on-line questionnaire (on intensity, progression and MSK-associated conditions, stone-related disease, pain features, drug use), the Brief Pain Inventory, the Fatigue Severity Score, and Wisconsin Quality of Life (WQL) in stone formers questionnaires. Ninety-two patients with a diagnosis of MSK joined our survey. Stone rate was very high (3.1 stones per patient-year, < 15% of patients had ≤ 1 stone per year). Most patients had repeated hospitalizations for stones symptoms (p < 0.001) or pain (p < 0.005). 71% of participants referred a daily pain that interfered strongly with everyday life and quality of life (WQL mean value 29.4). 69% used pain medications daily (70% opioids). In most cases, pain was associated with stone passage, while 15% referred a sine materia pain. We showed how MSK–CP symptoms affect very negatively on the quality of life of these patients. They also have a definite risk of progressing to end-stage kidney disease. Generally, CP seems to be associated with an exceptionally high lithogenic activity, suggesting that a better and earlier metabolic treatment for stone prevention should be the first approach in these patients before mini-invasive treatments to prevent pain.",
keywords = "Medullary sponge kidney, Nephrolitiasis, Pain, Renal colic, Renal stones",
author = "G. Gambaro and Goldfarb, {D. S.} and R. Baccaro and J. Hirsch and N. Topilow and S. D{\textquoteright}Alonzo and G. Gambassi and Ferraro, {P. M.}",
journal = "Journal of Nephrology",
publisher = "Springer International Publishing",
T1 - Chronic pain in medullary sponge kidney
T2 - a rare and never described clinical presentation
AU - Gambaro, G.
AU - Goldfarb, D. S.
AU - Baccaro, R.
AU - Hirsch, J.
AU - Topilow, N.
AU - D'Alonzo, S.
AU - Gambassi, G.
AU - Ferraro, P. M.
N2 - Medullary sponge kidney (MSK) is a cause of nephrocalcinosis, associated with hematuria, renal colic, pyelonephritis. There are rare and atypical MSK cases characterized by chronic severe pain (CP), whose features are unknown, in particular the relationship with the stone disease activity. This study analyzes a cohort of MSK–CP patients belonging to three North-America self-support Facebook groups. Patients had to self-administer an on-line questionnaire (on intensity, progression and MSK-associated conditions, stone-related disease, pain features, drug use), the Brief Pain Inventory, the Fatigue Severity Score, and Wisconsin Quality of Life (WQL) in stone formers questionnaires. Ninety-two patients with a diagnosis of MSK joined our survey. Stone rate was very high (3.1 stones per patient-year, < 15% of patients had ≤ 1 stone per year). Most patients had repeated hospitalizations for stones symptoms (p < 0.001) or pain (p < 0.005). 71% of participants referred a daily pain that interfered strongly with everyday life and quality of life (WQL mean value 29.4). 69% used pain medications daily (70% opioids). In most cases, pain was associated with stone passage, while 15% referred a sine materia pain. We showed how MSK–CP symptoms affect very negatively on the quality of life of these patients. They also have a definite risk of progressing to end-stage kidney disease. Generally, CP seems to be associated with an exceptionally high lithogenic activity, suggesting that a better and earlier metabolic treatment for stone prevention should be the first approach in these patients before mini-invasive treatments to prevent pain.
AB - Medullary sponge kidney (MSK) is a cause of nephrocalcinosis, associated with hematuria, renal colic, pyelonephritis. There are rare and atypical MSK cases characterized by chronic severe pain (CP), whose features are unknown, in particular the relationship with the stone disease activity. This study analyzes a cohort of MSK–CP patients belonging to three North-America self-support Facebook groups. Patients had to self-administer an on-line questionnaire (on intensity, progression and MSK-associated conditions, stone-related disease, pain features, drug use), the Brief Pain Inventory, the Fatigue Severity Score, and Wisconsin Quality of Life (WQL) in stone formers questionnaires. Ninety-two patients with a diagnosis of MSK joined our survey. Stone rate was very high (3.1 stones per patient-year, < 15% of patients had ≤ 1 stone per year). Most patients had repeated hospitalizations for stones symptoms (p < 0.001) or pain (p < 0.005). 71% of participants referred a daily pain that interfered strongly with everyday life and quality of life (WQL mean value 29.4). 69% used pain medications daily (70% opioids). In most cases, pain was associated with stone passage, while 15% referred a sine materia pain. We showed how MSK–CP symptoms affect very negatively on the quality of life of these patients. They also have a definite risk of progressing to end-stage kidney disease. Generally, CP seems to be associated with an exceptionally high lithogenic activity, suggesting that a better and earlier metabolic treatment for stone prevention should be the first approach in these patients before mini-invasive treatments to prevent pain.
KW - Medullary sponge kidney
KW - Nephrolitiasis
KW - Pain
KW - Renal colic
KW - Renal stones
JO - Journal of Nephrology
JF - Journal of Nephrology