Effects on thrombin generation of the platelet glycoprotein IIb/IIIa inhibitors abciximab versus tirofiban during coronary intervention
John A. Ambrose, Ramy Doss, Jean Pierre M Geagea, Marian C. Hawkey, Srinivas Duvuri, Kenneth Giedd, Alvaro Dominguez, John Coppola, Tien H. Nguyen, Venugopal Palla, Rajat S. Barua, Dhanonjoy C. Saha
The antithrombin generating effects of tirofiban were compared with abciximab in patients who underwent intervention and received intravenous heparin based on their weight. A standardized protocol serially measured the ACT, F1.2, and platelet receptor occupancy. Both GP IIb/IIIa agents had similar effects on reducing thrombin generation, and there were no significant differences between the groups at any measurement interval.
American Journal of Cardiology
Platelet Membrane Glycoprotein IIb
Integrin beta3
Platelet Glycoprotein GPIIb-IIIa Complex
Antithrombins
Ambrose, J. A., Doss, R., Geagea, J. P. M., Hawkey, M. C., Duvuri, S., Giedd, K., ... Saha, D. C. (2001). Effects on thrombin generation of the platelet glycoprotein IIb/IIIa inhibitors abciximab versus tirofiban during coronary intervention. American Journal of Cardiology, 87(10), 1231-1233. https://doi.org/10.1016/S0002-9149(01)01506-5
Effects on thrombin generation of the platelet glycoprotein IIb/IIIa inhibitors abciximab versus tirofiban during coronary intervention. / Ambrose, John A.; Doss, Ramy; Geagea, Jean Pierre M; Hawkey, Marian C.; Duvuri, Srinivas; Giedd, Kenneth; Dominguez, Alvaro; Coppola, John; Nguyen, Tien H.; Palla, Venugopal; Barua, Rajat S.; Saha, Dhanonjoy C.
In: American Journal of Cardiology, Vol. 87, No. 10, 15.05.2001, p. 1231-1233.
Ambrose, JA, Doss, R, Geagea, JPM, Hawkey, MC, Duvuri, S, Giedd, K, Dominguez, A, Coppola, J, Nguyen, TH, Palla, V, Barua, RS & Saha, DC 2001, 'Effects on thrombin generation of the platelet glycoprotein IIb/IIIa inhibitors abciximab versus tirofiban during coronary intervention', American Journal of Cardiology, vol. 87, no. 10, pp. 1231-1233. https://doi.org/10.1016/S0002-9149(01)01506-5
Ambrose JA, Doss R, Geagea JPM, Hawkey MC, Duvuri S, Giedd K et al. Effects on thrombin generation of the platelet glycoprotein IIb/IIIa inhibitors abciximab versus tirofiban during coronary intervention. American Journal of Cardiology. 2001 May 15;87(10):1231-1233. https://doi.org/10.1016/S0002-9149(01)01506-5
Ambrose, John A. ; Doss, Ramy ; Geagea, Jean Pierre M ; Hawkey, Marian C. ; Duvuri, Srinivas ; Giedd, Kenneth ; Dominguez, Alvaro ; Coppola, John ; Nguyen, Tien H. ; Palla, Venugopal ; Barua, Rajat S. ; Saha, Dhanonjoy C. / Effects on thrombin generation of the platelet glycoprotein IIb/IIIa inhibitors abciximab versus tirofiban during coronary intervention. In: American Journal of Cardiology. 2001 ; Vol. 87, No. 10. pp. 1231-1233.
@article{eaf844d6ac774417bfc2a3b8ce798225,
title = "Effects on thrombin generation of the platelet glycoprotein IIb/IIIa inhibitors abciximab versus tirofiban during coronary intervention",
abstract = "The antithrombin generating effects of tirofiban were compared with abciximab in patients who underwent intervention and received intravenous heparin based on their weight. A standardized protocol serially measured the ACT, F1.2, and platelet receptor occupancy. Both GP IIb/IIIa agents had similar effects on reducing thrombin generation, and there were no significant differences between the groups at any measurement interval.",
author = "Ambrose, {John A.} and Ramy Doss and Geagea, {Jean Pierre M} and Hawkey, {Marian C.} and Srinivas Duvuri and Kenneth Giedd and Alvaro Dominguez and John Coppola and Nguyen, {Tien H.} and Venugopal Palla and Barua, {Rajat S.} and Saha, {Dhanonjoy C.}",
journal = "American Journal of Cardiology",
T1 - Effects on thrombin generation of the platelet glycoprotein IIb/IIIa inhibitors abciximab versus tirofiban during coronary intervention
AU - Ambrose, John A.
AU - Doss, Ramy
AU - Geagea, Jean Pierre M
AU - Hawkey, Marian C.
AU - Duvuri, Srinivas
AU - Giedd, Kenneth
AU - Dominguez, Alvaro
AU - Coppola, John
AU - Nguyen, Tien H.
AU - Palla, Venugopal
AU - Barua, Rajat S.
AU - Saha, Dhanonjoy C.
N2 - The antithrombin generating effects of tirofiban were compared with abciximab in patients who underwent intervention and received intravenous heparin based on their weight. A standardized protocol serially measured the ACT, F1.2, and platelet receptor occupancy. Both GP IIb/IIIa agents had similar effects on reducing thrombin generation, and there were no significant differences between the groups at any measurement interval.
AB - The antithrombin generating effects of tirofiban were compared with abciximab in patients who underwent intervention and received intravenous heparin based on their weight. A standardized protocol serially measured the ACT, F1.2, and platelet receptor occupancy. Both GP IIb/IIIa agents had similar effects on reducing thrombin generation, and there were no significant differences between the groups at any measurement interval.
JO - American Journal of Cardiology
JF - American Journal of Cardiology