Publications of Note
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Mabin, J.W., P.W. Lewis, D.A. Brow, and H. Dvinge. (2021). Human spliceosomal snRNA sequence variants generate variant spliceosomes. RNA 27: 1186-1203
Montemayor EJ, Virta JM, Hayes SM, Nomura Y, Brow DA, Butcher SE. (2020). Molecular basis for the distinct cellular functions of the Lsm1-7 and Lsm2-8 complexes. RNA 26:1400-1413. PMCID: PMC7491322
Brow DA. (2019) An allosteric network for spliceosome activation revealed by high-throughput suppressor analysis in Saccharomyces cerevisiae. Genetics 212:111-124. PMCID: PMC6499515 (Highlighted article)
Didychuk AL, Butcher SE†, Brow DA†. (2018) The life of U6 small nuclear RNA, from cradle to grave. RNA 24:437-460. (Review) †corresponding author
Montemayor EJ†, Didychuk AL, Yake AD, Sidhu GK, Brow DA†, Butcher SE†. (2018) Architecture of the U6 snRNP reveals specific recognition of 3′-end processed U6 snRNA. Nature Communications 9:1749. †corresponding authors
Chen, X., Poorey, K., Wells, M.N., Müller, U., Bekiranov, S., Auble, D.T., and Brow, D.A. (2017) Transcriptomes of six mutants in the Sen1 pathway reveal combinatorial control of transcription termination across the Saccharomyces cerevisiae genome. PLOS Genetics, 13:e1006863.
Montemayor, E.J., Didychuk, A.L., Liao, H., Hu, P., Brow, D.A., and Butcher, S.E. (2017) Structure and conformational plasticity of the U6 small nuclear ribonucleoprotein core. Acta Cryst. D Struct. Biol., 73, 1-8.
Rodgers, M.L., Didychuk, A.L., Butcher, S.E., Brow, D.A., and Hoskins, A.A. (2016) A multi-step model for facilitated unwinding of the yeast U4/U6 RNA duplex. Nucl. Acids Res., 44, 10912-10928.
AL Didychuk, EJ Montemayor, DA Brow, SE Butcher. (2016) Structural requirements for protein-catalyzed annealing of U4 and U6 RNAs during di-snRNP assembly. Nucl. Acids Res. 44, 1398-1410.
S Martin-Tumasz and DA Brow. (2015). Saccharomyces cerevisiae Sen1 helicase domain exhibits 5' to 3' helicase activity with a preference for translocation on DNA rather than RNA. J. Biol. Chem. 290:22880-22889. (awarded "Paper of the Week")
Martin-Tumasz, S. and Brow, D.A. (2015) Saccharomyces cerevisiae Sen1 helicase domain exhibits 5' to 3' helicase activity with a preference for translocation on DNA rather than RNA. J. Biol. Chem., jbc.M115.674002 (epub)
Brow, DA. (2015) An RNA mystery and its denouement. RNA 21: 576-7.
Burke, JE, SE Butcher†, and DA Brow†. (2015) Spliceosome assembly in the absence of stable U4/U6 RNA pairing. RNA 21, 923-34
† corresponding authors
Chen X, Müller U, Sundling KE, Brow DA (2014) Saccharomyces cerevisiae Sen1 as a model for the study of mutations in human Senataxin that elicit cerebellar ataxia. Genetics 198(2):577-90 (PMC4196614)
Montemayor, E.J., Curran, E.C., Liao, H.H., Andrews, K.L., Treba, C.N., Butcher†, S.E. , and Brow†, D.A. (2014). Core structure of the U6 snRNP at 1.7 Å resolution. Nature Struct. Molec. Biol. 21(6):544-51 (PMC4141773) †corresponding authors.
Price, A.M., Görnemann, J., Guthrie, C., and Brow, D.A. (2014). An unanticipated early function of DEAD-box ATPase Prp28 during commitment to splicing is modulated by U5 snRNP protein Prp8. RNA 20, 46-60.
Brow, D.A. (2011). Sen-sing RNA terminators. Molec. Cell 42, 717-718.
Martin-Tumasz, S., Richie, A.C., Clos, L.J. II, Brow†, D.A., and Butcher†, S.E. (2011). A novel occluded RNA recognition motif in Prp24 unwinds the U6 RNA internal stem loop. Nucl. Acids Res. doi: 10.1093/nar/gkr455. †corresponding authors
Brow, D.A. (2009). Eye on RNA unwinding. Nature Struct. Mol. Biol. 16, 7-8.
Kuehner, J.N., and D.A. Brow. (2008). Regulation of a eukaryotic gene by GTP-dependent start site selection and transcription attenuation. Molec. Cell 31, 201-211. (Cover article)
McManus, C.J., M.L. Schwartz, S.E. Butcher, and D.A. Brow. (2007). A dynamic bulge in the U6 RNA internal stem-loop functions in spliceosome assembly and activation. RNA 13, 2252-2265.
Bae, E., N.J. Reiter, C.A. Bingman, S.S. Kwan, D. Lee, G.N. Phillips Jr., S.E. Butcher, and D.A. Brow. (2007). Structure and interactions of the first three RNA recognition motifs of splicing factor Prp24. J. Mol. Biol., 367, 1447-1458.
Steinmetz, E.J., C.L. Warren, J.N. Kuehner, B. Panbehi, A.Z. Ansari, and D.A. Brow. (2006). Genome-wide distribution of yeast RNA polymerase II and its control by Sen1 helicase. Molec. Cell 24, 735-746. (Cover article)