Purified anti-human CD70 Antibody
113-16 (See other available formats)
CD27 ligand, CD27L, Ki-24 antigen, Tumor necrosis factor ligand superfamily, member 7 (TNFSF7)
Mouse IgG1
Human myeloma cell line, U266, was stained with purified CD70 (clone 113-16, filled histogram) or mouse IgG1, κ isotype control (open histogram), followed by anti-mouse IgG PE.
355102 100 µg 92,00€
CD70, also known as CD27L, is a 50 kD type II transmembrane glycoprotein and member of the tumor necrosis factor superfamily. CD70 is expressed on activated T, B and NK cells, activated plasmacytoid dendritic cells (pDCs), and chronic B cell lymphocytic leukemia and large B cell lymphomas. CD70 costimulates T cell proliferation and differentiation. It plays a role in the pDC-induced B cell differentiation. The ligand of CD70 is CD27.
CD70-transfected L cells
The antibody was purified by affinity chromatography.
The antibody solution should be stored undiluted between 2°C and 8°C.
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Additional reported applications for the relevant formats include: blocking of plasmacytoid dendritic cell induced B cell proliferation and Ig secretion1.
Shaw J, et al. 2010. Blood 115:3051. (Block)
Tian Y, et al. 2019. Cell Rep. 29:4482. PubMed
Abolhassani H, et al. 2017. J Exp Med . 214(1):91-106. PubMed
Gabitova-Cornell L, et al. 2020. Cancer Cell. 38(4):567-583.e11. PubMed
Francescone R, et al. 2020. Cancer Discovery. 11(2):446-479. PubMed
Martin E, et al. 2020. JCI Insight. :5. PubMed
Type II transmembrane glycoprotein, member of the tumor necrosis factor superfamily, 50 kD
Activated T cells and B cells, activated NK cells, activated plasmacytoid dendritic cells, some B cell lymphomas
Role in T cell proliferation, generation of cytolytic and memory T cells, B cell proliferation and differentiation
B cells, Dendritic cells, NK cells, T cells
Costimulatory Molecules, Immunology
CD Molecules
1. Bowman MR, et al. 1994. J. Immunol. 152:1756.
2. Shaw J, et al. 2010. Blood 115:3051.
3. Keller AM, et al. 2009. Blood 113:5167.
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View information about CD70 on UniProt.org
Dendritic Cells
TNF Superfamily Pathway
View All CD70 Reagents Request Custom Conjugation
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