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C–C Bond Forming Reagents
Carbon-carbon (C–C) bond formation is a fundamental transformation of synthetic organic chemistry. The ability to elaborate and extend a carbon framework via a series of C–C bond-forming reactions is paramount to medicinal chemistry, agrochemical synthesis, and natural product synthesis.
Tremendous advances have been made in the synthetic methods available for C–C bond formation due to the development of robust and reliable protocols for cross-coupling, increased accessibility to various organometallic reagents, and the creation and improvement of stoichiometric reagents which serve to place a specific carbon-containing moiety.
We have a wide breadth of powerful C–C bond-forming reagents. Our phosphonium salts are used in Wittig reactions, and phosphonates are employed in Horner-Wadsworth-Emmons (HWE) reactions to create various alkene-containing products. We have a diverse selection of reagents for trifluoromethylation and difluoromethylation, many of which can be employed under mild conditions and have broad substrate scopes. Our extensive array of palladium, ruthenium, and other metal precatalysts and catalysts are optimal for various cross-coupling reactions. Additional carbon-carbon bond-forming reagents include boronic acids and derivatives, alkynes, triflates, and halogenated substrates. In addition, we have various catalysts for olefin and alkyne metathesis available for your research.
Trigger your organic reactions with our carbon-carbon bond-forming reagents to reach your new frontiers.
Functional Group
Greener Alternative Principles
Markush Class
Markush Group
Reaction Type
Reagent Type
XPhos, 98%
Methyltriphenylphosphonium bromide, 98%
cataCXium® A, 95%
rac-BINAP, 97%
Trimethyl(trifluoromethyl)silane, 99%
N,N-Dimethylformamide dimethyl acetal, technical grade, 94%
Triethyl phosphonoacetate, 98%
Dimethyl methylphosphonate, ≥98%
(Carbethoxymethylene)triphenylphosphorane, 95%
Benzyltriphenylphosphonium chloride, 99%
1,3-Bis(diphenylphosphino)propane, 97%
Tetrakis(dimethylamino)ethylene
(Methoxymethyl)triphenylphosphonium chloride, 97%
Trimethylsulfonium iodide, 98%
Methyl (triphenylphosphoranylidene)acetate, 98%
2-(2-Hydroxy-5-methylphenyl)benzotriazole, 97%
(Chloromethylene)dimethyliminium chloride, 95%
Ethyltriphenylphosphonium bromide, 99%
(Triphenylphosphoranylidene)acetaldehyde, 95%
Trimethyl phosphonoacetate, 98%
Buchwald Catalysts & Ligands
Buchwald Catalysts and Ligands are highly active and versatile palladium precatalysts and biarylphosphine ligands used in cross-coupling reactions for the formation of C-C, C–N, C–O, C–F, C–CF3, and C–S bonds.
Photocatalysts
Photocatalysis utilizes visible light to activate a chemical reaction. Our extensive portfolio of catalysts and photoreactors enable consistent reactions in photoredox catalysis.
Amino Acids, Resins & Reagents for Peptide Synthesis
We offer an extensive range of amino acids, resins, and reagents of unparalleled quality, including Novabiochem®, for peptide synthesis, high-throughput organic chemistry, labeling peptides, and custom manufactured products.
We're proud to offer a comprehensive portfolio of heterocyclic building blocks, one of the largest and most diverse families of molecular fragments used in organic synthesis.
Find the basic components needed to drive your research forward in our portfolio of organic building blocks which include Alkanes, Alkenes, Alkynes, Allenes, Arenes, Arsenic Compounds, Baran Functionalized Building Blocks, Baran Hindered Amines, Building Blocks and Chiral Small Molecules from Liverpool ChiroChem, Building Blocks for SuFEx: The Next Click Reaction, Carbenium Salts, an Carbonyl Compounds.
Chiral Auxiliaries
We offer an extensive range of ephedrine derivatives, oxazolidinone derivatives, and sulfur-based chiral auxiliaries for stereoselective protection in your asymmetric synthesis.
With a vast offering of fluorinated building blocks, such as, trifluoromethyl, difluoromethyl, triflate, and pentafluorosulfanyl substituents for your toolkit, we make it even easier to discover your target compounds.
C–H Activation Catalysts
Our unparalleled portfolio of C–H activation catalysts, auxiliaries, and oxidants provide reliable and predictable conversions of C–H bonds to C–C, C–N, C–O or C–X bonds.
Reaction Design & Optimization
Chemical reaction design and optimization in organic synthesis aims to precisely alter reaction parameters to achieve optimum results in finding pathways to target molecules.
C–H Functionalization
C–H functionalization is the reliable and predictable conversion of a C–H into a C–C, C–N, C–O, or C–X bond in a selective and controlled fashion.
Cross-Coupling
Cross-coupling is a common reaction in organic chemistry for the creation of C-C, C-N, and C-O bonds with the aid of a metal catalyst.
Fluorination
Fluorination is the introduction of fluorine to a compound via electrophilic fluorination, nucleophilic fluorination, difluoromethylation, trifluoromethylation, or perfluoroalkylation.
Metathesis
Olefin metathesis involves an organic reaction that redistributes fragments of alkenes (olefins) by cleavage and transformation of carbon-carbon double bonds.
Photoredox catalysis utilizes photocatalysts in the presence of visible light to form an array of synthetic transformations including, but not limited to, cross-coupling, C-H functionalization, alkene and arene functionalization, and trifluoromethylation.
Organic Reaction Toolbox
An organic reaction toolbox provides structure-activity relationships for unique chemical reactions to optimally design and control small molecule synthesis.
SYNTHIA™ Retrosynthesis Software
Our custom cell culture product design experts can offer advice and support as you scale your bioprocess from clinical to commercial supply, assisting with liquid products, dry powder products, selection of raw materials, quality testing, flexible product packaging, and product documentation.
Bulk Quotation Request
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Small Molecule Library Design (Aldrich Market Select)
Streamline the management of your screening compounds with our Aldrich Market Select online order center for small molecule libraries, comprising over 14 million chemistry building blocks and other useful services.
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