October 04, 2016; 87 (14) Resident and Fellow Section
Teaching NeuroImages: Morgagni-Stewart-Morel
A metabolic craniopathy
Joseph Bruno Bidin Brooks, Yara Dadalti Fragoso, Daniel Fantozzi Garcia, Wilson Araújo Silva, Guilherme Lopes da Silveira, Rodrigo André Oliveira
First published October 3, 2016, DOI: https://doi.org/10.1212/WNL.0000000000003178
Joseph Bruno Bidin Brooks
From the Departments of Function and Structure (J.B.B.B.) and Neurology (Y.D.F.), UNIMES–Universidade Metropolitana de Santos, São Paulo; Department of Genetics (D.F.G., W.A.S.), USP–Universidade de São Paulo, Ribeirão Preto; and Clínica Mega Imagem (G.L.d.S., R.A.O.), São Paulo, Brazil.
Yara Dadalti Fragoso
Daniel Fantozzi Garcia
Wilson Araújo Silva
Guilherme Lopes da Silveira
Rodrigo André Oliveira
Neurology Oct 2016, 87 (14) e161; DOI: 10.1212/WNL.0000000000003178
A 30-year-old woman presented with a 4-year history of slowly progressive memory loss, frontal headache, vertigo, depression, and seizures (normal EEG), and earlier history of endocrine disease (diabetes mellitus, obesity, hirsutism, and hypothyroidism). Sagittal cranial T1-weighted MRI, CT scan, and x-ray showed bilateral thickening of the inner table of the frontal bone (figure).1 Her paternal family history suggests X-linked disease. Her endocrine dysfunctions and neuropsychiatric symptoms are interpreted as components of Morgagni-Stewart-Morel syndrome and may correlate with the severity of the frontal hyperostosis and the cortical atrophy.2 Attention to this clinical–radiologic correlation may help neurologists make correct diagnoses.
Figure Frontal bone craniopathy
Sagittal cranial T1-weighted MRI (A), CT scan (B), and x-ray (C) of head.
Joseph Bruno Bidin Brooks: study concept and design. Yara Dadalti Fragoso: study supervision. Daniel Fantozzi Garcia: acquisition of data. Wilson Araújo Silva, Jr.: analysis and interpretation. Guilherme Lopes da Silveira: critical revision of the manuscript for important intellectual content. Rodrigo André Oliveira: acquisition of data.
STUDY FUNDING
No targeted funding reported.
The authors report no disclosures relevant to the manuscript. Go to Neurology.org for full disclosures.
↵* All authors contributed equally to this work.
Download teaching slides: Neurology.org
Harding FE
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Manzato E
. Full penetrance of Morgagni-Stewart-Morel syndrome in a 75-year-old woman: case report and review of the literature. J Clin Endocrinol Metab 2013;98:453–457.
All Epilepsy/Seizures
All Imaging