Genome of human hepatitis C virus (HCV): Gene organization, sequence diversity, and variation
N. Kato
Hepatitis C virus (HCV) is the major etiologic agent of non-A, non-B hepatitis. HCV infection frequently causes chronic hepatitis, which progresses to liver cirrhosis and hepatocellular carcinoma. Since the discovery of HCV in 1989, a large number of genetic analyses of HCV have been reported, and the viral genome structure has been elucidated. An enveloped virus, HCV belongs to the family Flaviviridae, whose genome consists of a positive-stranded RNA molecule of about 9.6 kilobases and encodes a large polyprotein precursor (about 3000 amino acids). This precursor protein is cleaved by the host and viral proteinase to generate at least 10 proteins: the core, envelope 1 (E1), E2, p7, nonstructural (NS) 2, NS3, NS4A, NS4B, NS5A, and NS5B. These HCV proteins not only function in viral replication but also affect a variety of cellular functions. HCV has been found to have remarkable genetic heterogeneity. To date, more than 30 HCV genotypes have been identified worldwide. Furthermore, HCV may show quasispecies distribution in an infected individual. These findings may have important implications in diagnosis, pathogenesis, treatment, and vaccine development. The hypervariable region 1 found within the envelope E2 protein was shown to be a major site for the genetic evolution of HCV after the onset of hepatitis, and might be involved in escape from the host immunesurveillance system.
Microbial and Comparative Genomics
https://doi.org/10.1089/omi.1.2000.5.129
10.1089/omi.1.2000.5.129
Dive into the research topics of 'Genome of human hepatitis C virus (HCV): Gene organization, sequence diversity, and variation'. Together they form a unique fingerprint.
Human Genome Medicine & Life Sciences 100%
Heterogeneity Chemical Compounds 22%
Hepatitis Medicine & Life Sciences 18%
Flaviviridae Medicine & Life Sciences 14%
Quasispecies Medicine & Life Sciences 13%
Kato, N. (2000). Genome of human hepatitis C virus (HCV): Gene organization, sequence diversity, and variation. Microbial and Comparative Genomics, 5(3), 129-151. https://doi.org/10.1089/omi.1.2000.5.129
Genome of human hepatitis C virus (HCV) : Gene organization, sequence diversity, and variation. / Kato, N.
In: Microbial and Comparative Genomics, Vol. 5, No. 3, 01.01.2000, p. 129-151.
Kato, N 2000, 'Genome of human hepatitis C virus (HCV): Gene organization, sequence diversity, and variation', Microbial and Comparative Genomics, vol. 5, no. 3, pp. 129-151. https://doi.org/10.1089/omi.1.2000.5.129
Kato N. Genome of human hepatitis C virus (HCV): Gene organization, sequence diversity, and variation. Microbial and Comparative Genomics. 2000 Jan 1;5(3):129-151. doi: 10.1089/omi.1.2000.5.129
Kato, N. / Genome of human hepatitis C virus (HCV) : Gene organization, sequence diversity, and variation. In: Microbial and Comparative Genomics. 2000 ; Vol. 5, No. 3. pp. 129-151.
@article{2c099fcb5338494fb78c0272cc93e741,
title = "Genome of human hepatitis C virus (HCV): Gene organization, sequence diversity, and variation",
abstract = "Hepatitis C virus (HCV) is the major etiologic agent of non-A, non-B hepatitis. HCV infection frequently causes chronic hepatitis, which progresses to liver cirrhosis and hepatocellular carcinoma. Since the discovery of HCV in 1989, a large number of genetic analyses of HCV have been reported, and the viral genome structure has been elucidated. An enveloped virus, HCV belongs to the family Flaviviridae, whose genome consists of a positive-stranded RNA molecule of about 9.6 kilobases and encodes a large polyprotein precursor (about 3000 amino acids). This precursor protein is cleaved by the host and viral proteinase to generate at least 10 proteins: the core, envelope 1 (E1), E2, p7, nonstructural (NS) 2, NS3, NS4A, NS4B, NS5A, and NS5B. These HCV proteins not only function in viral replication but also affect a variety of cellular functions. HCV has been found to have remarkable genetic heterogeneity. To date, more than 30 HCV genotypes have been identified worldwide. Furthermore, HCV may show quasispecies distribution in an infected individual. These findings may have important implications in diagnosis, pathogenesis, treatment, and vaccine development. The hypervariable region 1 found within the envelope E2 protein was shown to be a major site for the genetic evolution of HCV after the onset of hepatitis, and might be involved in escape from the host immunesurveillance system.",
author = "N. Kato",
doi = "10.1089/omi.1.2000.5.129",
journal = "OMICS A Journal of Integrative Biology",
T1 - Genome of human hepatitis C virus (HCV)
T2 - Gene organization, sequence diversity, and variation
AU - Kato, N.
N2 - Hepatitis C virus (HCV) is the major etiologic agent of non-A, non-B hepatitis. HCV infection frequently causes chronic hepatitis, which progresses to liver cirrhosis and hepatocellular carcinoma. Since the discovery of HCV in 1989, a large number of genetic analyses of HCV have been reported, and the viral genome structure has been elucidated. An enveloped virus, HCV belongs to the family Flaviviridae, whose genome consists of a positive-stranded RNA molecule of about 9.6 kilobases and encodes a large polyprotein precursor (about 3000 amino acids). This precursor protein is cleaved by the host and viral proteinase to generate at least 10 proteins: the core, envelope 1 (E1), E2, p7, nonstructural (NS) 2, NS3, NS4A, NS4B, NS5A, and NS5B. These HCV proteins not only function in viral replication but also affect a variety of cellular functions. HCV has been found to have remarkable genetic heterogeneity. To date, more than 30 HCV genotypes have been identified worldwide. Furthermore, HCV may show quasispecies distribution in an infected individual. These findings may have important implications in diagnosis, pathogenesis, treatment, and vaccine development. The hypervariable region 1 found within the envelope E2 protein was shown to be a major site for the genetic evolution of HCV after the onset of hepatitis, and might be involved in escape from the host immunesurveillance system.
AB - Hepatitis C virus (HCV) is the major etiologic agent of non-A, non-B hepatitis. HCV infection frequently causes chronic hepatitis, which progresses to liver cirrhosis and hepatocellular carcinoma. Since the discovery of HCV in 1989, a large number of genetic analyses of HCV have been reported, and the viral genome structure has been elucidated. An enveloped virus, HCV belongs to the family Flaviviridae, whose genome consists of a positive-stranded RNA molecule of about 9.6 kilobases and encodes a large polyprotein precursor (about 3000 amino acids). This precursor protein is cleaved by the host and viral proteinase to generate at least 10 proteins: the core, envelope 1 (E1), E2, p7, nonstructural (NS) 2, NS3, NS4A, NS4B, NS5A, and NS5B. These HCV proteins not only function in viral replication but also affect a variety of cellular functions. HCV has been found to have remarkable genetic heterogeneity. To date, more than 30 HCV genotypes have been identified worldwide. Furthermore, HCV may show quasispecies distribution in an infected individual. These findings may have important implications in diagnosis, pathogenesis, treatment, and vaccine development. The hypervariable region 1 found within the envelope E2 protein was shown to be a major site for the genetic evolution of HCV after the onset of hepatitis, and might be involved in escape from the host immunesurveillance system.
U2 - 10.1089/omi.1.2000.5.129
DO - 10.1089/omi.1.2000.5.129
JO - OMICS A Journal of Integrative Biology
JF - OMICS A Journal of Integrative Biology