Diagnosis and management of aspergillosis in the Netherlands: A national survey
Pieter P.A. Lestrade, Jacques F. Meis, Jan P. Arends, Martha T. van der Beek, Els de Brauwer, Karin van Dijk, Sabine C. de Greeff, Pieter Jan Haas, Caspar J. Hodiamont, Ed J. Kuijper, Tjalling Leenstra, Anouk E. Muller, Astrid M.L. Oude Lashof, Bart J. Rijnders, Eveline Roelofsen, Wouter Rozemeijer, Mathijs Tersmette, Elizabeth M. Terveer, Cees M. Verduin, Maurice J.H.M. WolfhagenWillem J.G. Melchers, Paul E. Verweij*
Medical Microbiology and Infection Prevention
A survey of diagnosis and treatment of invasive aspergillosis was conducted in eight University Medical Centers (UMCs) and eight non-academic teaching hospitals in the Netherlands. Against a background of emerging azole resistance in Aspergillus fumigatus routine resistance screening of clinical isolates was performed primarily in the UMCs. Azole resistance rates at the hospital level varied between 5% and 10%, although rates up to 30% were reported in high-risk wards. Voriconazole remained first choice for invasive aspergillosis in 13 out of 16 hospitals. In documented azole resistance 14 out of 16 centres treated patients with liposomal amphotericin B.
https://doi.org/10.1111/myc.12440
Published - 1 Feb 2016
10.1111/myc.12440
Lestrade, P. P. A., Meis, J. F., Arends, J. P., van der Beek, M. T., de Brauwer, E., van Dijk, K., de Greeff, S. C., Haas, P. J., Hodiamont, C. J., Kuijper, E. J., Leenstra, T., Muller, A. E., Oude Lashof, A. M. L., Rijnders, B. J., Roelofsen, E., Rozemeijer, W., Tersmette, M., Terveer, E. M., Verduin, C. M., ... Verweij, P. E. (2016). Diagnosis and management of aspergillosis in the Netherlands: A national survey. Mycoses, 59(2), 101-107. https://doi.org/10.1111/myc.12440
Lestrade, Pieter P.A. ; Meis, Jacques F. ; Arends, Jan P. et al. / Diagnosis and management of aspergillosis in the Netherlands : A national survey. In: Mycoses. 2016 ; Vol. 59, No. 2. pp. 101-107.
@article{286e4a14c9384b11bc82cef077c13b84,
title = "Diagnosis and management of aspergillosis in the Netherlands: A national survey",
abstract = "A survey of diagnosis and treatment of invasive aspergillosis was conducted in eight University Medical Centers (UMCs) and eight non-academic teaching hospitals in the Netherlands. Against a background of emerging azole resistance in Aspergillus fumigatus routine resistance screening of clinical isolates was performed primarily in the UMCs. Azole resistance rates at the hospital level varied between 5% and 10%, although rates up to 30% were reported in high-risk wards. Voriconazole remained first choice for invasive aspergillosis in 13 out of 16 hospitals. In documented azole resistance 14 out of 16 centres treated patients with liposomal amphotericin B.",
keywords = "Aspergillosis, Azole resistance, Treatment",
author = "Lestrade, {Pieter P.A.} and Meis, {Jacques F.} and Arends, {Jan P.} and {van der Beek}, {Martha T.} and {de Brauwer}, Els and {van Dijk}, Karin and {de Greeff}, {Sabine C.} and Haas, {Pieter Jan} and Hodiamont, {Caspar J.} and Kuijper, {Ed J.} and Tjalling Leenstra and Muller, {Anouk E.} and {Oude Lashof}, {Astrid M.L.} and Rijnders, {Bart J.} and Eveline Roelofsen and Wouter Rozemeijer and Mathijs Tersmette and Terveer, {Elizabeth M.} and Verduin, {Cees M.} and Wolfhagen, {Maurice J.H.M.} and Melchers, {Willem J.G.} and Verweij, {Paul E.}",
doi = "10.1111/myc.12440",
journal = "Mycoses",
Lestrade, PPA, Meis, JF, Arends, JP, van der Beek, MT, de Brauwer, E, van Dijk, K, de Greeff, SC, Haas, PJ, Hodiamont, CJ, Kuijper, EJ, Leenstra, T, Muller, AE, Oude Lashof, AML, Rijnders, BJ, Roelofsen, E, Rozemeijer, W, Tersmette, M, Terveer, EM, Verduin, CM, Wolfhagen, MJHM, Melchers, WJG & Verweij, PE 2016, 'Diagnosis and management of aspergillosis in the Netherlands: A national survey', Mycoses, vol. 59, no. 2, pp. 101-107. https://doi.org/10.1111/myc.12440
Diagnosis and management of aspergillosis in the Netherlands : A national survey. / Lestrade, Pieter P.A.; Meis, Jacques F.; Arends, Jan P. et al.
In: Mycoses, Vol. 59, No. 2, 01.02.2016, p. 101-107.
T1 - Diagnosis and management of aspergillosis in the Netherlands
T2 - A national survey
AU - Lestrade, Pieter P.A.
AU - Meis, Jacques F.
AU - Arends, Jan P.
AU - van der Beek, Martha T.
AU - de Brauwer, Els
AU - van Dijk, Karin
AU - de Greeff, Sabine C.
AU - Haas, Pieter Jan
AU - Hodiamont, Caspar J.
AU - Kuijper, Ed J.
AU - Leenstra, Tjalling
AU - Muller, Anouk E.
AU - Oude Lashof, Astrid M.L.
AU - Rijnders, Bart J.
AU - Roelofsen, Eveline
AU - Rozemeijer, Wouter
AU - Tersmette, Mathijs
AU - Terveer, Elizabeth M.
AU - Verduin, Cees M.
AU - Wolfhagen, Maurice J.H.M.
AU - Melchers, Willem J.G.
AU - Verweij, Paul E.
N2 - A survey of diagnosis and treatment of invasive aspergillosis was conducted in eight University Medical Centers (UMCs) and eight non-academic teaching hospitals in the Netherlands. Against a background of emerging azole resistance in Aspergillus fumigatus routine resistance screening of clinical isolates was performed primarily in the UMCs. Azole resistance rates at the hospital level varied between 5% and 10%, although rates up to 30% were reported in high-risk wards. Voriconazole remained first choice for invasive aspergillosis in 13 out of 16 hospitals. In documented azole resistance 14 out of 16 centres treated patients with liposomal amphotericin B.
AB - A survey of diagnosis and treatment of invasive aspergillosis was conducted in eight University Medical Centers (UMCs) and eight non-academic teaching hospitals in the Netherlands. Against a background of emerging azole resistance in Aspergillus fumigatus routine resistance screening of clinical isolates was performed primarily in the UMCs. Azole resistance rates at the hospital level varied between 5% and 10%, although rates up to 30% were reported in high-risk wards. Voriconazole remained first choice for invasive aspergillosis in 13 out of 16 hospitals. In documented azole resistance 14 out of 16 centres treated patients with liposomal amphotericin B.
KW - Aspergillosis
KW - Azole resistance
KW - Treatment
U2 - 10.1111/myc.12440
DO - 10.1111/myc.12440
JO - Mycoses
JF - Mycoses
Lestrade PPA, Meis JF, Arends JP, van der Beek MT, de Brauwer E, van Dijk K et al. Diagnosis and management of aspergillosis in the Netherlands: A national survey. Mycoses. 2016 Feb 1;59(2):101-107. doi: 10.1111/myc.12440