High Levels of IgA Antibodies to Helicobacter Pylori among Omani Women during Pregnancy and after Delivery
Mohammed Said Al-Balushi 1
Elias Anthony Said 1
Sidgi Syed Hasson 1
Juma Zaid Al-Busaidi 1
Iman Al-Reesi 1
Mohammed Idris 1
Wadha Al-Ghafri 2
Moza Al-Kalbani 2
Ali Abdullah Al-Jabri 1
1 Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman
2 Department of Obstetrics and Gynaecology, College of Medicine and Health Sciences, Sultan Qaboos University, Muscat, Oman
Background: Helicobacter pylori (H. pylori), is a common infection in pregnant women accompanied by variations in the levels of the IgM, IgA and IgG antibody isotypes. The variations of anti-H. pylori antibodies during and after pregnancy, and the extent of protection they provide to the mother and the fetus are not completely understood.
Objectives: To investigate the changes of the anti-H. pylori IgM, IgA and IgG levels in healthy Omani pregnant women during pregnancy and 3 months after delivery.
Methods: Serum samples obtained from 70 Omani healthy pregnant women, with no history of autoimmune diseases, were tested for anti-H. pylori IgM, IgA and IgG in the first trimester of pregnancy and 3 months after delivery. In parallel and as a control group, sera obtained from a group of 70 healthy non-pregnant Omani women were tested. The levels of anti-H. pylori IgM, IgA and IgG were measured using standard Enzyme Linked Immunosorbent Assays (ELISAs).
Results: Anti-H. pylori IgA levels were found to be significantly higher during pregnancy (p=0.046) and after delivery (p=0.02) when compared to the control group. Moreover, a significant increase in the levels of anti-H. pylori IgM, IgA and IgG was detected after delivery (p=0.002) when compared to the levels during pregnancy.
Conclusion: Pregnancy is associated with an increase in the levels of anti-H. pylori IgA antibodies. In addition, anti-H. pylori IgM, IgG and IgA antibody levels increase after delivery.
Al-Balushi, M., Anthony Said, E., Syed Hasson, S., Zaid Al-Busaidi, J., Al-Reesi, I., Idris, M., Al-Ghafri, W., Al-Kalbani, M., Al-Jabri, A. (2016). High Levels of IgA Antibodies to Helicobacter Pylori among Omani Women during Pregnancy and after Delivery. Iranian Journal of Immunology, 13(2), 114-123.
Mohammed Said Al-Balushi; Elias Anthony Said; Sidgi Syed Hasson; Juma Zaid Al-Busaidi; Iman Al-Reesi; Mohammed Idris; Wadha Al-Ghafri; Moza Al-Kalbani; Ali Abdullah Al-Jabri. "High Levels of IgA Antibodies to Helicobacter Pylori among Omani Women during Pregnancy and after Delivery". Iranian Journal of Immunology, 13, 2, 2016, 114-123.
Al-Balushi, M., Anthony Said, E., Syed Hasson, S., Zaid Al-Busaidi, J., Al-Reesi, I., Idris, M., Al-Ghafri, W., Al-Kalbani, M., Al-Jabri, A. (2016). 'High Levels of IgA Antibodies to Helicobacter Pylori among Omani Women during Pregnancy and after Delivery', Iranian Journal of Immunology, 13(2), pp. 114-123.
Al-Balushi, M., Anthony Said, E., Syed Hasson, S., Zaid Al-Busaidi, J., Al-Reesi, I., Idris, M., Al-Ghafri, W., Al-Kalbani, M., Al-Jabri, A. High Levels of IgA Antibodies to Helicobacter Pylori among Omani Women during Pregnancy and after Delivery. Iranian Journal of Immunology, 2016; 13(2): 114-123.