Reference Values for Mid-Ascending Aorta Diameters by Transthoracic Echocardiography in Adults
Chadi Ayoub, Gautam Kumar, Carin Y. Smith, Sandra C. Bryant, Diane M. Jech, Filip Ionescu, Ioana Petrescu, Fletcher A Jr. Miller, Peter C. Spittell
We sought to characterize mid-ascending aorta diameter reference values by age, sex, and body surface area (BSA) in a large echocardiography laboratory practice-based cohort. All subjects with transthoracic echocardiograms with mid-ascending aorta diameter measure from January 2004 to December 2009 were identified, and medical records were reviewed for medical history and anthropometric data. Those with aortic valve disease or replacement, congenital heart disease, any connective tissue or inflammatory disease that may affect the aorta, or known aortic aneurysm (>55 mm) were excluded. Mid-ascending aorta diameter was measured in a standardized manner using "leading edge to leading edge" technique at end-diastole. Of 27,839 eligible subjects, 16,620 did not have history of hypertension and were included in the analysis (56.3% female; mean age 52.0 ± 15.8 years), mean mid-ascending aorta diameter 31.7 ± 4.1 mm. Females had smaller diameter than males (30.5 ± 3.7 mm vs 33.3 ± 4.0 mm; p <0.001). Subjects with history of hypertension (n = 11,219; not included in the analysis) had larger mid-ascending aorta diameter compared with normotensive subjects (33.9 ± 3.8 mm vs 31.7 ± 4.1 mm; p < 0.001). Age had the greatest correlation with aortic size (r = 0.55), followed by sex (r = 0.35) and BSA (r = 0.35). Nomograms for predicted mid-ascending aorta diameter were generated at the 95th percentile using quantile regression for subjects without hypertension stratified by age, sex, and BSA. In conclusion, mid-ascending aorta diameter is predominantly associated with sex, age, and BSA. The nomograms established by this study may serve as useful reference values for echocardiographic screening and surveillance.
American Journal of Cardiology
https://doi.org/10.1016/j.amjcard.2018.06.006
Accepted/In press - Jan 1 2018
10.1016/j.amjcard.2018.06.006
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Aorta Medicine & Life Sciences 100%
Echocardiography Medicine & Life Sciences 96%
Body Surface Area Medicine & Life Sciences 64%
Nomograms Medicine & Life Sciences 35%
Hypertension Medicine & Life Sciences 27%
Aortic Diseases Medicine & Life Sciences 17%
Diastole Medicine & Life Sciences 17%
Ayoub, C., Kumar, G., Smith, C. Y., Bryant, S. C., Jech, D. M., Ionescu, F., Petrescu, I., Miller, F. A. J., & Spittell, P. C. (Accepted/In press). Reference Values for Mid-Ascending Aorta Diameters by Transthoracic Echocardiography in Adults. American Journal of Cardiology. https://doi.org/10.1016/j.amjcard.2018.06.006
Reference Values for Mid-Ascending Aorta Diameters by Transthoracic Echocardiography in Adults. / Ayoub, Chadi; Kumar, Gautam; Smith, Carin Y. et al.
In: American Journal of Cardiology, 01.01.2018.
Ayoub, C, Kumar, G, Smith, CY, Bryant, SC, Jech, DM, Ionescu, F, Petrescu, I, Miller, FAJ & Spittell, PC 2018, 'Reference Values for Mid-Ascending Aorta Diameters by Transthoracic Echocardiography in Adults', American Journal of Cardiology. https://doi.org/10.1016/j.amjcard.2018.06.006
Ayoub C, Kumar G, Smith CY, Bryant SC, Jech DM, Ionescu F et al. Reference Values for Mid-Ascending Aorta Diameters by Transthoracic Echocardiography in Adults. American Journal of Cardiology. 2018 Jan 1. doi: 10.1016/j.amjcard.2018.06.006
Ayoub, Chadi ; Kumar, Gautam ; Smith, Carin Y. et al. / Reference Values for Mid-Ascending Aorta Diameters by Transthoracic Echocardiography in Adults. In: American Journal of Cardiology. 2018.
@article{7ca2c333606f49d6920cdcedf8e9e635,
title = "Reference Values for Mid-Ascending Aorta Diameters by Transthoracic Echocardiography in Adults",
abstract = "We sought to characterize mid-ascending aorta diameter reference values by age, sex, and body surface area (BSA) in a large echocardiography laboratory practice-based cohort. All subjects with transthoracic echocardiograms with mid-ascending aorta diameter measure from January 2004 to December 2009 were identified, and medical records were reviewed for medical history and anthropometric data. Those with aortic valve disease or replacement, congenital heart disease, any connective tissue or inflammatory disease that may affect the aorta, or known aortic aneurysm (>55 mm) were excluded. Mid-ascending aorta diameter was measured in a standardized manner using "leading edge to leading edge" technique at end-diastole. Of 27,839 eligible subjects, 16,620 did not have history of hypertension and were included in the analysis (56.3% female; mean age 52.0 ± 15.8 years), mean mid-ascending aorta diameter 31.7 ± 4.1 mm. Females had smaller diameter than males (30.5 ± 3.7 mm vs 33.3 ± 4.0 mm; p <0.001). Subjects with history of hypertension (n = 11,219; not included in the analysis) had larger mid-ascending aorta diameter compared with normotensive subjects (33.9 ± 3.8 mm vs 31.7 ± 4.1 mm; p < 0.001). Age had the greatest correlation with aortic size (r = 0.55), followed by sex (r = 0.35) and BSA (r = 0.35). Nomograms for predicted mid-ascending aorta diameter were generated at the 95th percentile using quantile regression for subjects without hypertension stratified by age, sex, and BSA. In conclusion, mid-ascending aorta diameter is predominantly associated with sex, age, and BSA. The nomograms established by this study may serve as useful reference values for echocardiographic screening and surveillance.",
author = "Chadi Ayoub and Gautam Kumar and Smith, {Carin Y.} and Bryant, {Sandra C.} and Jech, {Diane M.} and Filip Ionescu and Ioana Petrescu and Miller, {Fletcher A Jr.} and Spittell, {Peter C.}",
doi = "10.1016/j.amjcard.2018.06.006",
journal = "American Journal of Cardiology",
T1 - Reference Values for Mid-Ascending Aorta Diameters by Transthoracic Echocardiography in Adults
AU - Ayoub, Chadi
AU - Kumar, Gautam
AU - Smith, Carin Y.
AU - Bryant, Sandra C.
AU - Jech, Diane M.
AU - Ionescu, Filip
AU - Petrescu, Ioana
AU - Miller, Fletcher A Jr.
AU - Spittell, Peter C.
N2 - We sought to characterize mid-ascending aorta diameter reference values by age, sex, and body surface area (BSA) in a large echocardiography laboratory practice-based cohort. All subjects with transthoracic echocardiograms with mid-ascending aorta diameter measure from January 2004 to December 2009 were identified, and medical records were reviewed for medical history and anthropometric data. Those with aortic valve disease or replacement, congenital heart disease, any connective tissue or inflammatory disease that may affect the aorta, or known aortic aneurysm (>55 mm) were excluded. Mid-ascending aorta diameter was measured in a standardized manner using "leading edge to leading edge" technique at end-diastole. Of 27,839 eligible subjects, 16,620 did not have history of hypertension and were included in the analysis (56.3% female; mean age 52.0 ± 15.8 years), mean mid-ascending aorta diameter 31.7 ± 4.1 mm. Females had smaller diameter than males (30.5 ± 3.7 mm vs 33.3 ± 4.0 mm; p <0.001). Subjects with history of hypertension (n = 11,219; not included in the analysis) had larger mid-ascending aorta diameter compared with normotensive subjects (33.9 ± 3.8 mm vs 31.7 ± 4.1 mm; p < 0.001). Age had the greatest correlation with aortic size (r = 0.55), followed by sex (r = 0.35) and BSA (r = 0.35). Nomograms for predicted mid-ascending aorta diameter were generated at the 95th percentile using quantile regression for subjects without hypertension stratified by age, sex, and BSA. In conclusion, mid-ascending aorta diameter is predominantly associated with sex, age, and BSA. The nomograms established by this study may serve as useful reference values for echocardiographic screening and surveillance.
AB - We sought to characterize mid-ascending aorta diameter reference values by age, sex, and body surface area (BSA) in a large echocardiography laboratory practice-based cohort. All subjects with transthoracic echocardiograms with mid-ascending aorta diameter measure from January 2004 to December 2009 were identified, and medical records were reviewed for medical history and anthropometric data. Those with aortic valve disease or replacement, congenital heart disease, any connective tissue or inflammatory disease that may affect the aorta, or known aortic aneurysm (>55 mm) were excluded. Mid-ascending aorta diameter was measured in a standardized manner using "leading edge to leading edge" technique at end-diastole. Of 27,839 eligible subjects, 16,620 did not have history of hypertension and were included in the analysis (56.3% female; mean age 52.0 ± 15.8 years), mean mid-ascending aorta diameter 31.7 ± 4.1 mm. Females had smaller diameter than males (30.5 ± 3.7 mm vs 33.3 ± 4.0 mm; p <0.001). Subjects with history of hypertension (n = 11,219; not included in the analysis) had larger mid-ascending aorta diameter compared with normotensive subjects (33.9 ± 3.8 mm vs 31.7 ± 4.1 mm; p < 0.001). Age had the greatest correlation with aortic size (r = 0.55), followed by sex (r = 0.35) and BSA (r = 0.35). Nomograms for predicted mid-ascending aorta diameter were generated at the 95th percentile using quantile regression for subjects without hypertension stratified by age, sex, and BSA. In conclusion, mid-ascending aorta diameter is predominantly associated with sex, age, and BSA. The nomograms established by this study may serve as useful reference values for echocardiographic screening and surveillance.
U2 - 10.1016/j.amjcard.2018.06.006
DO - 10.1016/j.amjcard.2018.06.006
JO - American Journal of Cardiology
JF - American Journal of Cardiology