05142_ch1_rat_p04
INCIDENCE RATES OF NONNEOPLASTIC LESIONS BY ANATOMIC SITE (a)
T-BUTYL ALCOHOL
NTP Experiment-Test: 05142-04                                                                                     Report: PEIRPT03
Study Type: CHRONIC                                                                                               Date: 05/20/95
Facility:  Southern Research Institute
Study Type: CHRONIC                                          T-BUTYL ALCOHOL                                      Date: 05/20/95
B6C3F1 MICE FEMALE                        VEHICLE        0.5%       1.0%         2.0%
Moribund Sacrifice                                13           14           13           12
Natural Death                                     10            8            4            4
Accidently Killed                                  1            3            2            2
Terminal Sacrifice                                36           35           40           42
Natural Death                                                                1
Gallbladder                                        (58)         (59)         (58)         (56)
Mucosa, Hyperplasia                                           1 (2%)       1 (2%)
Intestine Small, Duodenum                          (58)         (57)         (56)         (60)
Inflammation, Chronic                                                      1 (2%)
Perforation                                                                1 (2%)
Ulcer                                                         1 (2%)       1 (2%)
Intestine Small, Jejunum                           (57)         (56)         (57)         (60)
Developmental Malformation                                                 1 (2%)
Hyperplasia, Lymphoid                                                                   2 (3%)
Basophilic Focus                                 3 (5%)       1 (2%)                    2 (3%)
Clear Cell Focus                                              5 (8%)       3 (5%)
Eosinophilic Focus                              13 (22%)     14 (23%)     16 (27%)     20 (33%)
Fatty Change                                    11 (19%)      8 (13%)      8 (14%)      6 (10%)
Fibrosis, Focal                                  1 (2%)       1 (2%)       1 (2%)
Focal Cellular Change                                                                   1 (2%)
Hematopoietic Cell Proliferation                 1 (2%)       1 (2%)                    5 (8%)
Hemorrhage                                       1 (2%)                    1 (2%)
Infarct                                          1 (2%)       2 (3%)       2 (3%)
Infiltration Cellular, Mixed Cell                             1 (2%)
Inflammation, Focal                              5 (8%)       2 (3%)       7 (12%)      3 (5%)
Mineralization, Focal                            1 (2%)
Mixed Cell Focus                                 2 (3%)       5 (8%)       7 (12%)      4 (7%)
Necrosis                                                                   1 (2%)
Necrosis, Focal                                  2 (3%)       1 (2%)       2 (3%)       1 (2%)
Pigmentation                                     1 (2%)       3 (5%)       3 (5%)
Tension Lipidosis                                             1 (2%)       1 (2%)
Thrombosis                                       1 (2%)
Bile Duct, Hyperplasia                                                     1 (2%)
Centrilobular, Atrophy                                        1 (2%)
Centrilobular, Fibrosis                                                    1 (2%)       1 (2%)
Centrilobular, Necrosis                          2 (3%)                    2 (3%)       1 (2%)
ALIMENTARY SYSTEM - CONT
Mesentery                                          (24)         (17)         (17)         (12)
Cyst                                                                       1 (6%)
Hemorrhage                                       1 (4%)       1 (6%)
Inflammation, Chronic                            2 (8%)       2 (12%)      1 (6%)
Fat, Necrosis                                   14 (58%)     10 (59%)     12 (71%)      4 (33%)
Pancreas                                           (59)         (59)         (59)         (59)
Atrophy, Focal                                   3 (5%)       3 (5%)       1 (2%)
Acinar Cell, Focal Cellular Change                            1 (2%)
Duct, Dilatation                                              2 (3%)       1 (2%)
Cyst                                                                                    1 (2%)
Erosion                                          1 (2%)       1 (2%)       1 (2%)
Inflammation, Chronic                            4 (7%)       2 (3%)       1 (2%)       1 (2%)
Mineralization                                                             1 (2%)
Ulcer                                            2 (3%)                    1 (2%)       1 (2%)
Mucosa, Hyperplasia                              3 (5%)       5 (8%)       5 (8%)       4 (7%)
Stomach, Glandular                                 (60)         (60)         (59)         (59)
Angiectasis                                                                             1 (2%)
Erosion                                                       1 (2%)       1 (2%)
Pigmentation                                     1 (2%)                    1 (2%)
Ulcer                                                                      1 (2%)
Mucosa, Hyperplasia                              2 (3%)
Tooth                                              (3)          (2)          (1)          (3)
Incisor, Dysplasia                               3 (100%)     2 (100%)     1 (100%)     3 (100%)
Blood Vessel                                                                 (1)
Aorta, Bacterium                                                           1 (100%)
Aorta, Inflammation, Focal, Suppurative                                    1 (100%)
Aorta, Thrombosis                                                          1 (100%)
Heart                                              (60)         (60)         (60)         (60)
Hemorrhage                                       1 (2%)
Inflammation, Focal, Suppurative                                           1 (2%)
Mineralization, Focal                                         1 (2%)
Thrombosis                                                    1 (2%)
Congestion                                                    1 (2%)
Focal Cellular Change                            2 (3%)                    3 (5%)
Hematopoietic Cell Proliferation                                                        1 (2%)
Subcapsular, Hyperplasia, Focal                               3 (5%)
Parathyroid Gland                                  (48)         (56)         (57)         (50)
Angiectasis                                      1 (2%)       2 (4%)                    1 (2%)
Cyst                                                          1 (2%)       1 (2%)       1 (2%)
Hemorrhage                                                                              2 (3%)
Pars Distalis, Focal Cellular Change             6 (11%)      6 (11%)      6 (10%)      2 (3%)
Pars Distalis, Hyperplasia, Focal                1 (2%)       5 (9%)       5 (8%)       1 (2%)
Degeneration, Cystic                             8 (14%)      9 (15%)      9 (15%)      4 (7%)
Inflammation, Focal                              1 (2%)                                 1 (2%)
C-Cell, Hyperplasia                              2 (3%)
Follicle, Cyst                                                1 (2%)       1 (2%)
Follicular Cell, Cyst                                         1 (2%)       1 (2%)
Follicular Cell, Hyperplasia                    19 (33%)     28 (47%)     33 (56%)     47 (80%)
Clitoral Gland                                     (1)          (2)          (2)          (1)
Degeneration, Cystic                             1 (100%)     2 (100%)     1 (50%)      1 (100%)
Angiectasis                                      1 (2%)       2 (3%)       1 (2%)       1 (2%)
Hemorrhage                                       3 (5%)       1 (2%)       2 (3%)
Necrosis                                         1 (2%)
Thrombosis                                       1 (2%)                                 1 (2%)
Follicle, Cyst                                  15 (26%)     13 (22%)     17 (28%)     12 (20%)
Periovarian Tissue, Hemorrhage                                                          1 (2%)
Atrophy                                          1 (2%)
Decidual Reaction                                             1 (2%)
Exudate                                          1 (2%)
Hydrometra                                      20 (33%)     25 (42%)     19 (32%)     27 (46%)
Inflammation, Suppurative                        4 (7%)       1 (2%)       1 (2%)       3 (5%)
Endometrium, Hyperplasia, Cystic                58 (97%)     59 (98%)     58 (98%)     56 (95%)
Lymphatic, Ectasia                                            1 (2%)
Vagina                                                          (1)
Epithelium, Metaplasia                                        1 (100%)
Bone Marrow                                        (59)         (60)         (60)         (60)
Angiectasis                                      1 (2%)
Hypercellularity                                              1 (2%)
Lymph Node                                         (19)         (12)         (6)          (13)
Bronchial, Hyperplasia, Lymphoid                 1 (5%)
Iliac, Angiectasis                               1 (5%)                                 1 (8%)
Iliac, Hematopoietic Cell Proliferation          1 (5%)
Iliac, Hyperplasia                               1 (5%)       1 (8%)                    1 (8%)
Inguinal, Hyperplasia, Lymphoid                                            1 (17%)      1 (8%)
Inguinal, Hyperplasia, Mast Cell                                                        1 (8%)
Mediastinal, Angiectasis                         1 (5%)       1 (8%)
Mediastinal, Hyperplasia                                                   2 (33%)
Mediastinal, Hyperplasia, Lymphoid               3 (16%)
Renal, Hematopoietic Cell Proliferation          1 (5%)
Renal, Hyperplasia                               1 (5%)                                 1 (8%)
Hyperplasia                                      1 (2%)
Hyperplasia, Lymphoid                            1 (2%)       2 (3%)       1 (2%)
Lymph Node, Mesenteric                             (56)         (59)         (57)         (57)
Angiectasis                                                                2 (4%)       2 (4%)
Hematopoietic Cell Proliferation                              1 (2%)                    1 (2%)
Hemorrhage                                                                 1 (2%)
Hyperplasia, Lymphoid                            8 (14%)     10 (17%)      4 (7%)       4 (7%)
Hyperplasia, Macrophage                          1 (2%)
Depletion Cellular                               3 (5%)       2 (3%)                    1 (2%)
Fibrosis                                         1 (2%)
Hematopoietic Cell Proliferation                27 (46%)     25 (42%)     28 (47%)     20 (34%)
Hyperplasia, Lymphoid                           15 (25%)     18 (30%)     13 (22%)     18 (31%)
Pigmentation                                                                            1 (2%)
Thymus                                             (57)         (58)         (53)         (58)
Congestion                                       1 (2%)
Cyst                                             2 (4%)
Hyperplasia, Lymphoid                            3 (5%)       5 (9%)       3 (6%)       2 (3%)
Mammary Gland                                      (60)         (60)         (60)         (60)
Dilatation                                                    4 (7%)       4 (7%)       3 (5%)
Inflammation, Chronic                                                                   1 (2%)
Skin                                               (60)         (60)         (60)         (60)
Inflammation, Chronic, Focal                     1 (2%)       1 (2%)       1 (2%)       3 (5%)
Ulcer                                                                      1 (2%)       1 (2%)
INTEGUMENTARY SYSTEM - CONT
Epidermis, Hyperplasia, Focal                    1 (2%)
Sebaceous Gland, Hyperplasia                     1 (2%)
Subcutaneous Tissue, Edema                       2 (3%)       2 (3%)
Subcutaneous Tissue, Hyperplasia, Mast Cell                                1 (2%)
Bone                                               (60)         (60)         (60)         (60)
Fibrous Osteodystrophy                          30 (50%)     34 (57%)     34 (57%)     23 (38%)
Hyperostosis                                                  1 (2%)       1 (2%)
Brain                                              (60)         (60)         (60)         (60)
Compression                                      1 (2%)       3 (5%)       6 (10%)      2 (3%)
Cyst Epithelial Inclusion                                                               1 (2%)
Congestion                                       1 (2%)       2 (3%)                    3 (5%)
Foreign Body                                                                            3 (5%)
Hemorrhage                                       1 (2%)                                 4 (7%)
Hyperplasia, Macrophage                          1 (2%)       1 (2%)       2 (3%)       2 (3%)
Inflammation, Chronic, Focal                                               1 (2%)
Alveolar Epithelium, Hyperplasia                              3 (5%)                    2 (3%)
Nose                                               (60)         (60)         (60)         (60)
Inflammation, Suppurative                        4 (7%)       1 (2%)
Ear                                                             (1)                       (1)
Pinna, Inflammation, Chronic, Focal                           1 (100%)
Pinna, Ulcer                                                  1 (100%)
Eye                                                                                       (1)
Atrophy                                                                                 1 (100%)
Inflammation, Chronic                                                                   1 (100%)
Cyst                                                          1 (2%)
Inflammation, Suppurative                                                               1 (2%)
Metaplasia, Osseous                                                        2 (3%)       2 (3%)
Nephropathy                                     40 (68%)     37 (62%)     36 (61%)     31 (52%)
Pelvis, Dilatation                                            1 (2%)       2 (3%)
Renal Tubule, Degeneration, Hyaline              1 (2%)
Renal Tubule, Vacuolization Cytoplasmic                       1 (2%)
Urinary Bladder                                    (59)         (60)         (59)         (57)
Inflammation, Acute                                                                     1 (2%)
Transitional Epithelium, Hyperplasia                                                    3 (5%)
B6C3F1 MICE MALE                          VEHICLE      0.5%         1.0%         2.0%
Natural Death                                     13            8            6           22
Accidently Killed                                               2            1
Esophagus                                          (60)         (60)         (60)         (60)
Inflammation, Focal, Suppurative                                                        1 (2%)
Ulcer                                                         1 (2%)
Hyperplasia, Lymphoid                                                      1 (2%)       1 (2%)
Inflammation, Chronic                            1 (2%)                                 1 (2%)
Ulcer                                                                                   1 (2%)
Intestine Small, Ileum                             (56)         (56)         (57)         (55)
Hyperplasia, Lymphoid                            2 (4%)
Angiectasis                                                   3 (5%)       1 (2%)
Basophilic Focus                                 2 (3%)       8 (13%)     10 (17%)      6 (10%)
Clear Cell Focus                                10 (17%)     25 (42%)     21 (36%)     20 (34%)
Congestion                                                                 1 (2%)
Fatty Change                                    12 (20%)      5 (8%)       8 (14%)     29 (49%)
Fibrosis, Focal                                               1 (2%)
Hematopoietic Cell Proliferation                 2 (3%)       1 (2%)
Hemorrhage                                                    1 (2%)       1 (2%)
Infiltration Cellular, Mixed Cell                                          1 (2%)
Inflammation, Focal                              2 (3%)                    3 (5%)
Mixed Cell Focus                                 4 (7%)       4 (7%)       3 (5%)       5 (8%)
Tension Lipidosis                                                                       5 (8%)
Thrombosis                                                                 1 (2%)
Centrilobular, Necrosis                                       1 (2%)       1 (2%)       1 (2%)
Mesentery                                          (5)          (6)          (7)          (4)
Angiectasis                                                                             1 (25%)
Hyperplasia, Mast Cell                                        1 (17%)
Inflammation, Chronic                            1 (20%)                   2 (29%)      1 (25%)
Fat, Necrosis                                    1 (20%)      3 (50%)      3 (43%)      2 (50%)
Edema                                            1 (2%)                    1 (2%)
Necrosis                                                                                1 (2%)
Duct, Dilatation                                              1 (2%)
Erosion                                                       2 (3%)
Inflammation, Chronic                            6 (10%)      4 (7%)       1 (2%)       7 (12%)
Ulcer                                            1 (2%)       1 (2%)       1 (2%)       4 (7%)
Mucosa, Hyperplasia                              7 (12%)      7 (12%)      1 (2%)       4 (7%)
Erosion                                                       1 (2%)                    3 (5%)
Inflammation, Chronic                            1 (2%)
Mineralization                                   1 (2%)                                 2 (4%)
Pigmentation                                     1 (2%)       3 (5%)                    2 (4%)
Mucosa, Hyperplasia                              4 (7%)                                 2 (4%)
Tooth                                              (44)         (41)         (33)         (26)
Incisor, Dysplasia                              44 (100%)    41 (100%)    33 (100%)    26 (100%)
Incisor, Inflammation, Suppurative                                         1 (3%)
Blood Vessel                                       (1)          (1)
Mesenteric Artery, Inflammation, Chronic         1 (100%)
Accessory Adrenal Cortical Nodule                             1 (2%)                    2 (3%)
Cyst                                             1 (2%)       1 (2%)       1 (2%)
Focal Cellular Change                            2 (3%)       6 (10%)      1 (2%)       1 (2%)
Subcapsular, Hyperplasia, Focal                  5 (8%)       7 (12%)      7 (12%)      1 (2%)
Cyst                                             2 (4%)                                 2 (4%)
Degeneration, Cystic                                          1 (2%)
Cyst                                             2 (4%)       1 (2%)                    3 (6%)
Pars Distalis, Focal Cellular Change             1 (2%)
Degeneration, Cystic                             7 (12%)      5 (8%)      10 (17%)      5 (9%)
Inflammation, Focal                                                        1 (2%)
Follicle, Cyst                                   1 (2%)
Follicular Cell, Hyperplasia                     5 (8%)      18 (31%)     15 (25%)     18 (32%)
Coagulating Gland                                  (23)         (13)         (21)         (4)
Dilatation                                      23 (100%)    13 (100%)    21 (100%)     4 (100%)
Granuloma Sperm                                  4 (7%)       1 (2%)       2 (3%)       3 (5%)
Inflammation, Chronic                                                      3 (5%)       1 (2%)
Penis                                                           (1)
Inflammation, Chronic                                         1 (100%)
Necrosis                                                      1 (100%)
Preputial Gland                                    (27)         (36)         (24)         (21)
Degeneration, Cystic                            26 (96%)     33 (92%)     23 (96%)     21 (100%)
Inflammation, Chronic                            2 (7%)       5 (14%)      1 (4%)       1 (5%)
Prostate                                           (60)         (60)         (60)         (58)
Dilatation                                       2 (3%)       1 (2%)       2 (3%)
Inflammation, Chronic                                         2 (3%)       2 (3%)       1 (2%)
Seminal Vesicle                                    (60)         (60)         (60)         (60)
Congestion                                                                              1 (2%)
Dilatation                                      35 (58%)     31 (52%)     36 (60%)     11 (18%)
Hemorrhage                                       2 (3%)       3 (5%)       1 (2%)       2 (3%)
Degeneration                                                                            1 (2%)
Granuloma Sperm                                  1 (2%)
Mineralization                                                             1 (2%)       1 (2%)
Germinal Epithelium, Degeneration                2 (3%)                                 6 (10%)
Angiectasis                                      1 (2%)                    1 (2%)
Hypercellularity                                 2 (3%)                                 1 (2%)
Page   10
Myelofibrosis, Focal                                          1 (2%)
Lymph Node                                         (9)          (5)          (1)          (1)
Angiectasis                                      1 (11%)                   1 (100%)
Inguinal, Cyst                                                                          1 (100%)
Inguinal, Hyperplasia                                         1 (20%)
Inguinal, Hyperplasia, Lymphoid                               2 (40%)
Mediastinal, Hyperplasia                         3 (33%)
Pancreatic, Hyperplasia                                       1 (20%)
Renal, Hyperplasia                               1 (11%)      1 (20%)
Hyperplasia                                      2 (4%)                    2 (3%)       1 (2%)
Hyperplasia, Lymphoid                                         1 (2%)       1 (2%)
Angiectasis                                     13 (22%)     23 (40%)     17 (30%)     13 (23%)
Hematopoietic Cell Proliferation                 1 (2%)       4 (7%)       4 (7%)
Hyperplasia                                      1 (2%)       1 (2%)
Hyperplasia, Lymphoid                           10 (17%)      6 (10%)      9 (16%)      8 (14%)
Depletion Cellular                               2 (3%)       6 (10%)      5 (8%)      25 (44%)
Fibrosis                                         1 (2%)                                 1 (2%)
Hyperplasia, Lymphoid                            7 (12%)     12 (20%)      8 (14%)      7 (12%)
Cyst                                             9 (17%)      3 (6%)       7 (13%)      5 (10%)
Hyperplasia, Lymphoid                                         1 (2%)
Mineralization                                                1 (2%)
Epithelial Cell, Hyperplasia                     1 (2%)
Inflammation, Chronic, Focal                     1 (2%)       2 (3%)       2 (3%)
Epidermis, Hyperplasia, Focal                                 1 (2%)       1 (2%)
Hair Follicle, Atrophy                                                                  1 (2%)
Subcutaneous Tissue, Abscess                     1 (2%)
Subcutaneous Tissue, Edema                       1 (2%)                    1 (2%)
Subcutaneous Tissue, Hemorrhage                  1 (2%)
Subcutaneous Tissue, Inflammation, Chronic                    1 (2%)
Fibrous Osteodystrophy                           1 (2%)
Hyperostosis                                                                            2 (3%)
Congestion                                                    1 (2%)       1 (2%)       5 (8%)
Foreign Body                                                  1 (2%)
Hemorrhage                                       1 (2%)       1 (2%)                    1 (2%)
Hyperplasia, Macrophage                          4 (7%)       1 (2%)       1 (2%)
Infiltration Cellular, Mixed Cell                1 (2%)       2 (3%)
Inflammation, Acute, Focal                                                              1 (2%)
Inflammation, Chronic, Focal                     2 (3%)                    1 (2%)
Alveolar Epithelium, Hyperplasia                 4 (7%)       4 (7%)       2 (3%)       1 (2%)
Artery, Thrombosis                               1 (2%)
Bronchus, Epithelium, Hyperplasia                             1 (2%)
Inflammation, Suppurative                        1 (2%)                                 1 (2%)
Eye                                                (2)                       (1)
Inflammation, Chronic                            1 (50%)
Harderian Gland                                    (10)         (3)          (3)          (1)
Atrophy, Focal                                                                          1 (2%)
Congestion                                                    1 (2%)                    4 (7%)
Cyst                                             7 (12%)      4 (7%)       3 (5%)       1 (2%)
Hydronephrosis                                                1 (2%)       1 (2%)
Artery, Inflammation, Chronic                                              1 (2%)       1 (2%)
Pelvis, Dilatation                               3 (5%)       1 (2%)       1 (2%)       1 (2%)
Renal Tubule, Dilatation                         2 (3%)                    1 (2%)       3 (5%)
Ureter                                                                                    (1)
Dilatation                                                                              1 (100%)
Urethra                                            (1)          (2)                       (3)
Angiectasis                                                   1 (50%)
Dilatation                                                    1 (50%)                   1 (33%)
Inflammation, Acute                                           1 (50%)
Inflammation, Chronic                            1 (100%)                               2 (67%)
Bulbourethral Gland, Angiectasis                              1 (50%)
Calculus Gross Observation, Multiple,
Greater Than Five                                                                   1 (2%)
Dilatation                                       3 (5%)       2 (3%)       2 (3%)       2 (3%)
Inflammation, Chronic                                         3 (5%)       1 (2%)      37 (63%)
Artery, Inflammation, Chronic                                                           1 (2%)
Transitional Epithelium, Hyperplasia             1 (2%)       3 (5%)       1 (2%)      17 (29%)