In Vivo Dynamic Nuclear Polarization Magnetic Resonance Imaging for the Evaluation of Redox-Related Diseases and Theranostics
Fuminori Hyodo, Hinako Eto, Tatsuya Naganuma, Norikazu Koyasu, Abdelazim Elsayed Elhelaly, Yoshifumi Noda, Hiroki Kato, Masaharu Murata, Tomohiko Akahoshi, Makoto Hashizume, Hideo Utsumi, Masayuki Matsuo
Center for Advanced Medical Open Innovation
Significance: In vivo molecular and metabolic imaging is an emerging field in biomedical research that aims to perform noninvasive detection of tissue metabolism in disease states and responses to therapeutic agents. The imbalance in tissue oxidation/reduction (Redox) states is related to the onset and progression of several diseases. Tissue redox metabolism provides biomarkers for early diagnosis and drug treatments. Thus, noninvasive imaging of redox metabolism could be a useful, novel diagnostic tool for diagnosis of redox-related disease and drug discovery. Recent Advances: In vivo dynamic nuclear polarization magnetic resonance imaging (DNP-MRI) is a technique that enables the imaging of free radicals in living animals. DNP enhances the MRI signal by irradiating the target tissue or solution with the free radical molecule's electron paramagnetic resonance frequency before executing pulse sequence of the MRI. In vivo DNP-MRI with redox-sensitive nitroxyl radicals as the DNP redox contrast agent enables the imaging of the redox metabolism on various diseases. Moreover, nitroxyl radicals show antioxidant effects that suppress oxidative stress. Critical Issues: To date, considerable progress has been documented preclinically in the development of animal imaging systems. Here, we review redox imaging of in vivo DNP-MRI with a focus on the recent progress of this system and its uses in patients with redox-related diseases. Future Directions: This technique could have broad applications in the study of other redox-related diseases, such as cancer, inflammation, and neurological disorders, and facilitate the evaluation of treatment response as a theranostic tool. Antioxid. Redox Signal. 36, 172-184.
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Dynamic Nuclear Polarization Biochemistry, Genetics and Molecular Biology 100%
Diseases Medicine and Dentistry 87%
Magnetic Resonance Imaging Medicine and Dentistry 75%
Metabolism Medicine and Dentistry 37%
Metabolic Pathway Biochemistry, Genetics and Molecular Biology 37%
Diagnosis Medicine and Dentistry 25%
Tissues Medicine and Dentistry 25%
Hyodo, F., Eto, H., Naganuma, T., Koyasu, N., Elhelaly, A. E., Noda, Y., Kato, H., Murata, M., Akahoshi, T., Hashizume, M., Utsumi, H., & Matsuo, M. (2022). In Vivo Dynamic Nuclear Polarization Magnetic Resonance Imaging for the Evaluation of Redox-Related Diseases and Theranostics. Antioxidants and Redox Signaling, 36(1-3), 172-184. https://doi.org/10.1089/ars.2021.0087
In Vivo Dynamic Nuclear Polarization Magnetic Resonance Imaging for the Evaluation of Redox-Related Diseases and Theranostics. / Hyodo, Fuminori; Eto, Hinako; Naganuma, Tatsuya et al.
In: Antioxidants and Redox Signaling, Vol. 36, No. 1-3, 01.01.2022, p. 172-184.
Hyodo, F, Eto, H, Naganuma, T, Koyasu, N, Elhelaly, AE, Noda, Y, Kato, H, Murata, M, Akahoshi, T, Hashizume, M, Utsumi, H & Matsuo, M 2022, 'In Vivo Dynamic Nuclear Polarization Magnetic Resonance Imaging for the Evaluation of Redox-Related Diseases and Theranostics', Antioxidants and Redox Signaling, vol. 36, no. 1-3, pp. 172-184. https://doi.org/10.1089/ars.2021.0087
Hyodo F, Eto H, Naganuma T, Koyasu N, Elhelaly AE, Noda Y et al. In Vivo Dynamic Nuclear Polarization Magnetic Resonance Imaging for the Evaluation of Redox-Related Diseases and Theranostics. Antioxidants and Redox Signaling. 2022 Jan 1;36(1-3):172-184. doi: 10.1089/ars.2021.0087
Hyodo, Fuminori ; Eto, Hinako ; Naganuma, Tatsuya et al. / In Vivo Dynamic Nuclear Polarization Magnetic Resonance Imaging for the Evaluation of Redox-Related Diseases and Theranostics. In: Antioxidants and Redox Signaling. 2022 ; Vol. 36, No. 1-3. pp. 172-184.
@article{9df5840bbc004d9aa3ba156d36913b3a,
title = "In Vivo Dynamic Nuclear Polarization Magnetic Resonance Imaging for the Evaluation of Redox-Related Diseases and Theranostics",
abstract = "Significance: In vivo molecular and metabolic imaging is an emerging field in biomedical research that aims to perform noninvasive detection of tissue metabolism in disease states and responses to therapeutic agents. The imbalance in tissue oxidation/reduction (Redox) states is related to the onset and progression of several diseases. Tissue redox metabolism provides biomarkers for early diagnosis and drug treatments. Thus, noninvasive imaging of redox metabolism could be a useful, novel diagnostic tool for diagnosis of redox-related disease and drug discovery. Recent Advances: In vivo dynamic nuclear polarization magnetic resonance imaging (DNP-MRI) is a technique that enables the imaging of free radicals in living animals. DNP enhances the MRI signal by irradiating the target tissue or solution with the free radical molecule's electron paramagnetic resonance frequency before executing pulse sequence of the MRI. In vivo DNP-MRI with redox-sensitive nitroxyl radicals as the DNP redox contrast agent enables the imaging of the redox metabolism on various diseases. Moreover, nitroxyl radicals show antioxidant effects that suppress oxidative stress. Critical Issues: To date, considerable progress has been documented preclinically in the development of animal imaging systems. Here, we review redox imaging of in vivo DNP-MRI with a focus on the recent progress of this system and its uses in patients with redox-related diseases. Future Directions: This technique could have broad applications in the study of other redox-related diseases, such as cancer, inflammation, and neurological disorders, and facilitate the evaluation of treatment response as a theranostic tool. Antioxid. Redox Signal. 36, 172-184. ",
author = "Fuminori Hyodo and Hinako Eto and Tatsuya Naganuma and Norikazu Koyasu and Elhelaly, {Abdelazim Elsayed} and Yoshifumi Noda and Hiroki Kato and Masaharu Murata and Tomohiko Akahoshi and Makoto Hashizume and Hideo Utsumi and Masayuki Matsuo",
note = "Funding Information: This work was supported by the Medical Research and Development Programs Focused on Technology Transfer, Development of Advanced Measurement, and Analysis Systems (SENTAN) from the Japan Agency for Medical Research and Development, Grant Number 162128. This work was also supported by Japan Society for the Promotion of Science KAKENHI (Grant Numbers 18H02765 and 19H03358) and MEXT Quantum Leap Flagship Program (MEXT Q-LEAP) Grant Number JPMXS0120330644. Publisher Copyright: {\textcopyright} Copyright 2022, Mary Ann Liebert, Inc., publishers 2022.",
T1 - In Vivo Dynamic Nuclear Polarization Magnetic Resonance Imaging for the Evaluation of Redox-Related Diseases and Theranostics
AU - Hyodo, Fuminori
AU - Eto, Hinako
AU - Naganuma, Tatsuya
AU - Koyasu, Norikazu
AU - Elhelaly, Abdelazim Elsayed
AU - Noda, Yoshifumi
AU - Kato, Hiroki
AU - Murata, Masaharu
AU - Akahoshi, Tomohiko
AU - Hashizume, Makoto
AU - Utsumi, Hideo
AU - Matsuo, Masayuki
N1 - Funding Information: This work was supported by the Medical Research and Development Programs Focused on Technology Transfer, Development of Advanced Measurement, and Analysis Systems (SENTAN) from the Japan Agency for Medical Research and Development, Grant Number 162128. This work was also supported by Japan Society for the Promotion of Science KAKENHI (Grant Numbers 18H02765 and 19H03358) and MEXT Quantum Leap Flagship Program (MEXT Q-LEAP) Grant Number JPMXS0120330644. Publisher Copyright: © Copyright 2022, Mary Ann Liebert, Inc., publishers 2022.
N2 - Significance: In vivo molecular and metabolic imaging is an emerging field in biomedical research that aims to perform noninvasive detection of tissue metabolism in disease states and responses to therapeutic agents. The imbalance in tissue oxidation/reduction (Redox) states is related to the onset and progression of several diseases. Tissue redox metabolism provides biomarkers for early diagnosis and drug treatments. Thus, noninvasive imaging of redox metabolism could be a useful, novel diagnostic tool for diagnosis of redox-related disease and drug discovery. Recent Advances: In vivo dynamic nuclear polarization magnetic resonance imaging (DNP-MRI) is a technique that enables the imaging of free radicals in living animals. DNP enhances the MRI signal by irradiating the target tissue or solution with the free radical molecule's electron paramagnetic resonance frequency before executing pulse sequence of the MRI. In vivo DNP-MRI with redox-sensitive nitroxyl radicals as the DNP redox contrast agent enables the imaging of the redox metabolism on various diseases. Moreover, nitroxyl radicals show antioxidant effects that suppress oxidative stress. Critical Issues: To date, considerable progress has been documented preclinically in the development of animal imaging systems. Here, we review redox imaging of in vivo DNP-MRI with a focus on the recent progress of this system and its uses in patients with redox-related diseases. Future Directions: This technique could have broad applications in the study of other redox-related diseases, such as cancer, inflammation, and neurological disorders, and facilitate the evaluation of treatment response as a theranostic tool. Antioxid. Redox Signal. 36, 172-184.
AB - Significance: In vivo molecular and metabolic imaging is an emerging field in biomedical research that aims to perform noninvasive detection of tissue metabolism in disease states and responses to therapeutic agents. The imbalance in tissue oxidation/reduction (Redox) states is related to the onset and progression of several diseases. Tissue redox metabolism provides biomarkers for early diagnosis and drug treatments. Thus, noninvasive imaging of redox metabolism could be a useful, novel diagnostic tool for diagnosis of redox-related disease and drug discovery. Recent Advances: In vivo dynamic nuclear polarization magnetic resonance imaging (DNP-MRI) is a technique that enables the imaging of free radicals in living animals. DNP enhances the MRI signal by irradiating the target tissue or solution with the free radical molecule's electron paramagnetic resonance frequency before executing pulse sequence of the MRI. In vivo DNP-MRI with redox-sensitive nitroxyl radicals as the DNP redox contrast agent enables the imaging of the redox metabolism on various diseases. Moreover, nitroxyl radicals show antioxidant effects that suppress oxidative stress. Critical Issues: To date, considerable progress has been documented preclinically in the development of animal imaging systems. Here, we review redox imaging of in vivo DNP-MRI with a focus on the recent progress of this system and its uses in patients with redox-related diseases. Future Directions: This technique could have broad applications in the study of other redox-related diseases, such as cancer, inflammation, and neurological disorders, and facilitate the evaluation of treatment response as a theranostic tool. Antioxid. Redox Signal. 36, 172-184.