prowley@uidaho.edu
Rowley Lab Website
Paul Andrew Rowley Assistant Professor
Participating Faculty, Center for Modeling Complex Interactions
Member, Institute for Bioinformatics and Evolutionary Studies (IBEST) , University of Idaho
Assistant Professor, Biological Sciences , College of Science 2016 -
My B.A. at The University of Warwick (UK) introduced me to the fascinating aspects of how viruses cause disease. After working in the food safety industry I began a PhD studying the biology of bacterial viruses (Aberdeen, UK). After relocating to Texas, I studied viruses that infect higher organisms, including yeast and primates (including humans!) using techniques from molecular biology and evolution. I continued this work as a postdoc at The Biofrontiers Institute (Boulder, CO).
A Rapid Method for Sequencing Double-Stranded RNAs Purified from Yeasts and the Identification of a Potent K1 Killer Toxin Isolated from Saccharomyces cerevisiae. Viruses-Basel. 11:70. 2019
The Evolution Of Nucleoporin 153 And Its Effect On HIV Nuclear Entry. Journal of Investigative Medicine. 67:204-205. 2019
Control of yeast retrotransposons mediated through nucleoporin evolution. PLOS Genetics. 14:e1007325. 2018
The frenemies within: viruses, retrotransposons and plasmids that naturally infect Saccharomyces yeasts. Yeast. 34.0:279.0-292.0. 2017
XRN1 Is a Species-Specific Virus Restriction Factor in Yeasts. PLOS Pathogens. 12. 2016
The partitioning and copy number control systems of the selfish yeast plasmid: an optimized molecular design for stable persistence in host cells. Microbiology Spectrum. 2. 2014
Organization of DNA partners and strand exchange mechanisms during Flp site-specific recombination analyzed by difference topology, single molecule FRET and single molecule TPM. Journal of Molecular Biology. 426:793-815. 2014
Positive selection of primate genes that promote HIV-1 replication. Virology. 454-455:291-298. 2014
Temporal sequence and cell cycle cues in the assembly of host factors at the yeast 2 micron plasmid partitioning locus. Nucleic Acids Research. 41:2340-2353. 2013
Selfish Nucleic acids. Encyclopedia of Genetics. 2. 2012
Restoration of catalytic functions in Cre recombinase mutants by electrostatic compensation between active site and DNA substrate. Nucleic Acids Research. 38:6589-6601. 2010
Electrostatic suppression allows tyrosine site-specific recombination in the absence of a conserved catalytic arginine. Journal of Biological Chemistry. 285:22976-22985. 2010
Site-specific recombination by C31 integrase and other large serine recombinases. Biochemical Society Transactions. 38:388-394. 2010
Active site electrostatics protect genome integrity by blocking abortive hydrolysis during DNA recombination. Embo Journal. 28:1745-1756. 2009
DNA binding and synapsis by the large C-terminal domain of C31 integrase. Nucleic Acids Research. 37:4764-4773. 2009
Metabolic engineering without plasmids. Nature Biotechnology. 27:729-731. 2009
A motif in the C-terminal domain of C31 integrase controls the directionality of recombination. Nucleic Acids Research. 36:3879-3891. 2008
Role of the N-terminal domain of C31 integrase in attB-attP synapsis. Journal of Bacteriology. 190:6918-6921. 2008
Collaborative Research: Eukaryotic virus-host interaction and evolution in Saccharomyces yeasts awarded by NSF Division of Molecular and Cellular Biosciences (MCB) 2018 - 2022
Ph.D. in Molecular Biology, University of Aberdeen 2007
B.S. in Microbiology and Virology, University of Warwick 2002
Paul Andrew Rowley