Widely used types and clinical applications of D-dimer assay
Roger S. Riley, Andrea R. Gilbert, Justin B. Dalton, Sheela Pai, Richard A. McPherson
D-dimers are formed by the breakdown of fibrinogen and fibrin during fibrinolysis. D-dimer analysis is critical for the diagnosis of deep vein thrombosis, pulmonary embolism, and disseminated intravascular coagulation. Modern assays for D-dimer are monoclonal antibody based. The enzyme-linked immunosorbent assay (ELISA) is the reference method for D-dimer analysis in the central clinical laboratory, but is time consuming to perform. Recently, a number of rapid, point-of-care D-dimer assays have been developed for acute care settings that utilize a variety of methodologies. In view of the diversity of D-dimer assays used in central laboratory and point-of-care settings, several caveats must be taken to assure the proper interpretation and clinical application of the results. These include consideration of preanalytical variables and interfering substances, as well as patient drug therapy and underlying disease. D-dimer assays should also be validated in clinical studies, have established cut-off values, and reported according to the reagent manufacturers recommendations.
https://doi.org/10.1093/labmed/lmw001
Chemiluminescent immunoassay
D-dimer testing
Fibrinogen degradation products
Immunoassay
10.1093/labmed/lmw001
Dive into the research topics of 'Widely used types and clinical applications of D-dimer assay'. Together they form a unique fingerprint.
D Dimer Chemical Compounds 100%
fibrin fragment D Medicine & Life Sciences 73%
Point-of-Care Systems Medicine & Life Sciences 19%
Application Chemical Compounds 19%
Fibrin Chemical Compounds 10%
Disseminated Intravascular Coagulation Medicine & Life Sciences 10%
Fibrinolysis Medicine & Life Sciences 9%
Coagulation Chemical Compounds 9%
Riley, R. S., Gilbert, A. R., Dalton, J. B., Pai, S., & McPherson, R. A. (2016). Widely used types and clinical applications of D-dimer assay. Lab Medicine, 47(2), 90-102. https://doi.org/10.1093/labmed/lmw001
Widely used types and clinical applications of D-dimer assay. / Riley, Roger S.; Gilbert, Andrea R.; Dalton, Justin B.; Pai, Sheela; McPherson, Richard A.
In: Lab Medicine, Vol. 47, No. 2, 05.2016, p. 90-102.
Riley, RS, Gilbert, AR, Dalton, JB, Pai, S & McPherson, RA 2016, 'Widely used types and clinical applications of D-dimer assay', Lab Medicine, vol. 47, no. 2, pp. 90-102. https://doi.org/10.1093/labmed/lmw001
Riley RS, Gilbert AR, Dalton JB, Pai S, McPherson RA. Widely used types and clinical applications of D-dimer assay. Lab Medicine. 2016 May;47(2):90-102. https://doi.org/10.1093/labmed/lmw001
Riley, Roger S. ; Gilbert, Andrea R. ; Dalton, Justin B. ; Pai, Sheela ; McPherson, Richard A. / Widely used types and clinical applications of D-dimer assay. In: Lab Medicine. 2016 ; Vol. 47, No. 2. pp. 90-102.
@article{814f33e1dc204302bc5d0a687650889d,
title = "Widely used types and clinical applications of D-dimer assay",
abstract = "D-dimers are formed by the breakdown of fibrinogen and fibrin during fibrinolysis. D-dimer analysis is critical for the diagnosis of deep vein thrombosis, pulmonary embolism, and disseminated intravascular coagulation. Modern assays for D-dimer are monoclonal antibody based. The enzyme-linked immunosorbent assay (ELISA) is the reference method for D-dimer analysis in the central clinical laboratory, but is time consuming to perform. Recently, a number of rapid, point-of-care D-dimer assays have been developed for acute care settings that utilize a variety of methodologies. In view of the diversity of D-dimer assays used in central laboratory and point-of-care settings, several caveats must be taken to assure the proper interpretation and clinical application of the results. These include consideration of preanalytical variables and interfering substances, as well as patient drug therapy and underlying disease. D-dimer assays should also be validated in clinical studies, have established cut-off values, and reported according to the reagent manufacturers recommendations.",
keywords = "Blood coagulation, Cancer, Chemiluminescent immunoassay, Coronary artery disease, D-dimer testing, Disseminated intravascular coagulation, Fibrinogen degradation products, Heart disease, Immunoassay, Point-of-care testing, Pulmonary embolism, Venous thromboembolism, Venous thrombosis",
author = "Riley, {Roger S.} and Gilbert, {Andrea R.} and Dalton, {Justin B.} and Sheela Pai and McPherson, {Richard A.}",
note = "Publisher Copyright: {\textcopyright} American Society for Clinical Pathology, 2016. All rights reserved.",
doi = "10.1093/labmed/lmw001",
journal = "Laboratory Medicine",
publisher = "American Society of Clinical Pathologists",
T1 - Widely used types and clinical applications of D-dimer assay
AU - Riley, Roger S.
AU - Gilbert, Andrea R.
AU - Dalton, Justin B.
AU - Pai, Sheela
AU - McPherson, Richard A.
N1 - Publisher Copyright: © American Society for Clinical Pathology, 2016. All rights reserved.
N2 - D-dimers are formed by the breakdown of fibrinogen and fibrin during fibrinolysis. D-dimer analysis is critical for the diagnosis of deep vein thrombosis, pulmonary embolism, and disseminated intravascular coagulation. Modern assays for D-dimer are monoclonal antibody based. The enzyme-linked immunosorbent assay (ELISA) is the reference method for D-dimer analysis in the central clinical laboratory, but is time consuming to perform. Recently, a number of rapid, point-of-care D-dimer assays have been developed for acute care settings that utilize a variety of methodologies. In view of the diversity of D-dimer assays used in central laboratory and point-of-care settings, several caveats must be taken to assure the proper interpretation and clinical application of the results. These include consideration of preanalytical variables and interfering substances, as well as patient drug therapy and underlying disease. D-dimer assays should also be validated in clinical studies, have established cut-off values, and reported according to the reagent manufacturers recommendations.
AB - D-dimers are formed by the breakdown of fibrinogen and fibrin during fibrinolysis. D-dimer analysis is critical for the diagnosis of deep vein thrombosis, pulmonary embolism, and disseminated intravascular coagulation. Modern assays for D-dimer are monoclonal antibody based. The enzyme-linked immunosorbent assay (ELISA) is the reference method for D-dimer analysis in the central clinical laboratory, but is time consuming to perform. Recently, a number of rapid, point-of-care D-dimer assays have been developed for acute care settings that utilize a variety of methodologies. In view of the diversity of D-dimer assays used in central laboratory and point-of-care settings, several caveats must be taken to assure the proper interpretation and clinical application of the results. These include consideration of preanalytical variables and interfering substances, as well as patient drug therapy and underlying disease. D-dimer assays should also be validated in clinical studies, have established cut-off values, and reported according to the reagent manufacturers recommendations.
KW - Blood coagulation
KW - Chemiluminescent immunoassay
KW - Coronary artery disease
KW - D-dimer testing
KW - Disseminated intravascular coagulation
KW - Fibrinogen degradation products
KW - Heart disease
KW - Immunoassay
KW - Point-of-care testing
KW - Pulmonary embolism
KW - Venous thromboembolism
KW - Venous thrombosis
U2 - 10.1093/labmed/lmw001
DO - 10.1093/labmed/lmw001
JO - Laboratory Medicine
JF - Laboratory Medicine