Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on Colorectal Cancer
Dis Colon Rectum. 2014 Aug;57(8):1025-48. doi: 10.1097/DCR.000000000000000.
Francis M Giardiello 1 , John I Allen, Jennifer E Axilbund, C Richard Boland, Carol A Burke, Randall W Burt, James M Church, Jason A Dominitz, David A Johnson, Tonya Kaltenbach, Theodore R Levin, David A Lieberman, Douglas J Robertson, Sapna Syngal, Douglas K Rex
1 1Johns Hopkins University School of Medicine, Baltimore, Maryland 2Yale University School of Medicine, New Haven, Connecticut 3Baylor University Medical Center at Dallas, Texas 4Cleveland Clinic, Cleveland, Ohio 5University of Utah, Salt Lake City, Utah 6VA Puget Sound Health Care System, Seattle, Washington 7University of Washington, Seattle, Washington 8Eastern Virginia Medical School, Norfolk, Virginia 9Stanford University, Palo Alto, California 10Kaiser Permanente Medical Center, Walnut Creek, California 11Oregon Health and Science University, Portland, Oregon 12White River Junction VA Medical Center, White River Junction, Vermont 13Geisel School of Medicine at Dartmouth, White River Junction, Vermont 14Brigham and Women's Hospital, Boston, Massachusetts 15Dana Farber Cancer Institute, Boston, Massachusetts 16Harvard Medical School, Boston, Massachusetts 17Indiana University School of Medicine, Indianapolis, Indiana.
DOI: 10.1097/DCR.000000000000000
The Multi-Society Task Force, in collaboration with invited experts, developed guidelines to assist health care providers with the appropriate provision of genetic testing and management of patients at risk for and affected with Lynch syndrome as follows: provides a colorectal cancer risk assessment tool to screen individuals in the office or endoscopy setting; illustrates a strategy for universal screening for Lynch syndrome by tumor testing of patients diagnosed with colorectal cancer; -6 provide algorithms for genetic evaluation of affected and at-risk family members of pedigrees with Lynch syndrome; provides guidelines for screening at-risk and affected persons with Lynch syndrome; and lists the guidelines for the management of patients with Lynch syndrome. A detailed explanation of Lynch syndrome and the methodology utilized to derive these guidelines, as well as an explanation of, and supporting literature for, these guidelines are provided.
Neoplasms / genetics*
Neoplasms, Multiple Primary / genetics*