Volume 18, Issue 2 (Summer 2012) IJPCP 2012, 18(2): 115-137 | Back to browse issues page
Shahrivar Z, Alaghband-rad J, Mahmoudi Gharaie J, Seddigh A, Salesian N, Jalali Roodsari M et al . The Efficacy of an Integrated Treatment in Comparison with Treatment as Usual in a Group of Children and Adolescents with First-Episode Psychosis during a Two Year Follow-up . IJPCP. 2012; 18 (2) :115-137
The Efficacy of an Integrated Treatment in Comparison with Treatment as Usual in a Group of Children and Adolescents with First-Episode Psychosis during a Two Year Follow-up
Zahra Shahrivar *1, Javad Alaghband-rad2, Javad Mahmoudi Gharaie2, Arshia Seddigh2, Niloofar Salesian2, Mohsen Jalali Roodsari2, Payam Sobhe Bidari2
1- Roozbeh Hospital , sharivar@sina.tums.ac.ir
2- Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Objectives: This study aimed to compare the efficacy of an integrated treatment (IT) versus treatment as usual (TAU) in a group of inpatient children and adolescents with first episode psychosis (FEP) during a two year follow-up. Method: In a randomized controlled trial, 40 children and adolescents with FEP based on DSM-IV criteria were recruited from referrals to Robe Hospital (Tehran, Iran). They were divided into a TAU group (N=20), and an IT group (N=20) who received a low dose of atypical antipsychotic medications and family psycho-education program, and were followed up by telephone contacts. All participants were evaluated at admission and discharge as well as in 6, 12, 18 and 24 month intervals using the Kiddie-Schedule for Affective Disorders and Schizophrenia-Present and Lifetime Version-Persian Version (K-SADS-PL-PV), Positive and Negative Syndrome Scale (PANSS), Young Mania Rating Scale (YMRS), Children's Depression Inventory (CDI), Hamilton Depression Rating Scale (HAM-D), Global Assessment of Functioning Scale (GAF), and Children Global Assessment Scale (CGAS). Statistical methods consisted of analysis of independent t and c2 for qualitative variables, and random effect regression model for quantitative variables. Results: The two groups showed significant improvement in all outcome measures at different time-points. The rate and duration of recurrences were lower in the IT group compared to the TAU group. All of the other outcome measures were comparable in the two groups and there was no difference between them in different follow-up periods. Conclusion: Integrated treatment may decrease the rate and duration of recurrences in children and adolescents with FEP.
Keywords: first episode psychosis, children, adolescents, treatment as usual, efficacy
Type of Study: Original Research | Subject: Psychiatry and Psychology
Received: 2012/10/31