Carlos Alan Candido Dias Junior
CV Lattes ResearcherID ORCID
Universidade Estadual Paulista (UNESP). Campus de Botucatu. Instituto de Biociências (IBB) (Institutional affiliation for the last research proposal)
Associate Professor of Pharmacology, UNESP, Botucatu, Sao Paulo, Department of Pharmacology. Pharmacist (2002). Master (2004) and PhD (2007) in Pharmacology (USP, Ribeirão Preto, Sao Paulo). Postdoctoral Research Fellow at Department of Pharmacology (USP, 2009) and at Harvard Medical School (2016). Adviser of masters and PhD students, Biological Sciences Program (Area: Pharmacology and Biotechnology, UNESP, Botucatu, Sao Paulo). The main focus is cardiovascular pharmacology. (Source: Lattes Curriculum)
Hypertensive disorders of pregnancy are characterized by an increase in systemic blood pressure. Preeclampsia is considered the most severe of these disorders and is usually accompanied by proteinuria and other clinical symptoms after the 20th gestational week. Perivascular adipose tissue (PVAT) may participate in the control of vascular tone through the release of vasoactive substances, …
Pharmacological characterization of perivascular adipose tissue (PVAT)-derived hydrogen sulphide (H2S) in gestational hypertension in rats, AP.R
Under gestation period, several cardiovascular adaptations must occur to maintain a healthy pregnancy. Preeclampsia (PE) is a disorder that occurs during pregnancy that is characterized by elevated maternal blood pressure (140x90mmHg) accompanied by proteinuria in 24-hour urine after the 20th week of pregnancy. Its pathogenesis is still unclear; however, the placenta seems to play a key r…
Evaluation of the role of hydrogen sulfide (H2S) in hypertension in pregnancy, AP.R
Taking into account that there are controversial antioxidative effects of inhalational anesthetics isoflurane and sevoflurane and absence of comparison of genotoxicity of both anesthetics in animal model, the aim of this study was to compare DNA damage and antioxidant status in Wistar rats exposed to a single time to isoflurane or sevoflurane. The alkaline single-cell gel electrophoresis …
Sevoflurane induces DNA damage whereas isoflurane leads to higher antioxidative status in anesthetized rats, PUB.ART
During the gestational period, several cardiovascular adaptations must take place to maintain a healthy pregnancy. Preeclampsia (PE) is a disorder that occurs in pregnancy and is characterized by elevated maternal blood pressure (140x90mmHg) accompanied by 24-hour proteinuria after the 20th gestational week. Its pathogenesis is still unclear, however, the placenta seems to play a fundamen…
Impact of esomeprazole on the nitric oxide bioavailability in Gestational Hypertension in rats, BP.DD
Pre-eclampsia is a gestational hypertensive disorder characterized by systolic and diastolic blood pressure commonly greater than 140/90 mmHg and which usually appears after the 20th week of pregnancy. Studies suggest increases in oxidative stress and antiangiogenic factors in pre-eclampsia with a concomitant reduction in vasodilator mediators and deficient placentation, which are accompa…
Evaluation of cardiovascular repercussions in virgin and pregnant adult rats, descendants of the first generation, of rats with experimentally induced gestational hypertension, BP.IC
Hypertensive disorders of pregnancy are the main causes of maternal and fetal mortality, characterized by elevations in maternal blood pressure which may compromise fetal development. The pathogenesis is still unknown, but there are theories that there is a decrease in the plasticity of the vessels of the maternal-fetal interface, placental ischemia accompanied by maternal endothelial dys…
Influence evaluation of the pravastatin antioxidant effects on the gelatinolytic activity of metalloproteinases 2 and 9 hypertensive pregnant rats, BP.IC
Preeclampsia is featured by increases in systolic and diastolic blood pressures, often followed by proteinuria after the 20th gestational week. Theories suggest that preeclampsia may be caused by poor placentation and that this diminishes the elasticity of the maternal-fetal interface vessels, impairing blood flow to the uterus and that may cause placental hypoperfusion and ischemia, whic…
Evaluation of cardiovascular repercussions in first-generation offspring adult rats in an experimental model of gestational hypertension, BP.IC
The use of inhalational anesthetics has been increasingly studied in non-elective surgeries in pregnant women, since this approach is necessary in emergency procedures. Thus, examining the vascular repercussions of anesthesia at the gestation may provide support for assessing the cardiovascular effects on the mother, minimizing the risk of fetal impairment, and preventing preterm labor. I…
Evaluation of vascular reactivity and gelatinolytic activity of metalloproteinases 2 and 9 following isoflurane anesthesia in pregnant rats, BP.IC
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Preeclampsia affects 5-8% of pregnancies and is characterized by increased blood pressure and proteinuria from 20 weeks of gestation. These changes appear to be initially related to placental ischemia, causing insufficient uteroplacental oxygenation followed by increased release of anti-angiogenic factors such as sFlt-1 (soluble fms-like tyrosine kinase-1, which is a soluble VEGF receptor…
Effects of sodium nitrite and its association with sildenafil in experimental models of preeclampsia, BE.PQ
6 / 5 Completed research grants
1 / 1 Completed scholarships abroad
15 / 13 All research grants and scholarships
Maria Luiza Santos da Silva
Jose Eduardo Tanus dos Santos
Gabryella Mendes
Carolina Rosa Rodrigues de Souza
Erick Ewdrill Pereira de Macedo
Cristal de Jesus Toghi
Filipe Trindade Bozoni
Biological Sciences Health Sciences Medicine Pharmacology
POSSOMATO-VIEIRA, JOSE S.; CHIMINI, JESSICA S.; DA SILVA, MARIA L. S.; DIAS-JUNIOR, CARLOS A.. Increases in placental nitric oxide, but not nitric oxide-mediated relaxation, underlie the improvement in placental efficiency and antihypertensive effects of hydrogen sulphide donor in hypertensive pregnancy. Clinical and experimental pharmacology & physiology, v. 45, n. 11, p. 1118-1127, NOV 2018. Web of Science Citations: 2. (16/18782-3)