The Changes of Hepatic Metallothionein Synthesis and the Hepatic Damage Induced by Starvation in Mice
N. Sogawa, C. A. Sogawa, H. Fukuoka, Y. Mukubo, T. Yoneyama, Y. Okano, H. Furuta, Kenji Onodera
Metallothionein (MT) is induced in the liver not only by heavy metals, but also by stress such as starvation. However the meaning of the induced MT during starvation has never been clear. In this study, we investigated the relationship between changes in hepatic MT synthesis and the hepatic damage that occurs during starvation. MT synthesis was assessed by measuring MT contents and the expression of the MT gene in the liver. The hepatic damage was assessed by measuring glutamic pyruvic transaminase (GPT) and glutamic oxaloacetic transaminase (GOT) activities in the serum. MT synthesis in the liver increased over the normal level by starvation, but decreased under the normal level by refeeding after starvation. Both GPT and GOT activities of the refeeding group were higher than those of the control group. However, MT synthesis increased by a subcutaneous injection with CdCl2 (1 mg Cd/kg) at the same time as refeeding after starvation. At this point, GOT activity decreased until it reached the normal level. MT synthesis decreased by refeeding after starvation, and from the results found in this study, we proposed the hypothesis that the liver damage caused by refeeding after starvation might be due to the decrease in the synthesis of a sufficient amount of MT induced by metals.
Methods and Findings in Experimental and Clinical Pharmacology
https://doi.org/10.1358/mf.2003.25.8.778079
Hepatic damage
Metallothionein
10.1358/mf.2003.25.8.778079
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Metallothionein Medicine & Life Sciences
Starvation Medicine & Life Sciences
Aspartate Aminotransferases Medicine & Life Sciences
Alanine Transaminase Medicine & Life Sciences
Cadmium Chloride Medicine & Life Sciences
Heavy Metals Medicine & Life Sciences
Subcutaneous Injections Medicine & Life Sciences
Sogawa, N., Sogawa, C. A., Fukuoka, H., Mukubo, Y., Yoneyama, T., Okano, Y., Furuta, H., & Onodera, K. (2003). The Changes of Hepatic Metallothionein Synthesis and the Hepatic Damage Induced by Starvation in Mice. Methods and Findings in Experimental and Clinical Pharmacology, 25(8), 601-606. https://doi.org/10.1358/mf.2003.25.8.778079
The Changes of Hepatic Metallothionein Synthesis and the Hepatic Damage Induced by Starvation in Mice. / Sogawa, N.; Sogawa, C. A.; Fukuoka, H.; Mukubo, Y.; Yoneyama, T.; Okano, Y.; Furuta, H.; Onodera, Kenji.
In: Methods and Findings in Experimental and Clinical Pharmacology, Vol. 25, No. 8, 10.2003, p. 601-606.
Sogawa, N, Sogawa, CA, Fukuoka, H, Mukubo, Y, Yoneyama, T, Okano, Y, Furuta, H & Onodera, K 2003, 'The Changes of Hepatic Metallothionein Synthesis and the Hepatic Damage Induced by Starvation in Mice', Methods and Findings in Experimental and Clinical Pharmacology, vol. 25, no. 8, pp. 601-606. https://doi.org/10.1358/mf.2003.25.8.778079
Sogawa N, Sogawa CA, Fukuoka H, Mukubo Y, Yoneyama T, Okano Y et al. The Changes of Hepatic Metallothionein Synthesis and the Hepatic Damage Induced by Starvation in Mice. Methods and Findings in Experimental and Clinical Pharmacology. 2003 Oct;25(8):601-606. https://doi.org/10.1358/mf.2003.25.8.778079
Sogawa, N. ; Sogawa, C. A. ; Fukuoka, H. ; Mukubo, Y. ; Yoneyama, T. ; Okano, Y. ; Furuta, H. ; Onodera, Kenji. / The Changes of Hepatic Metallothionein Synthesis and the Hepatic Damage Induced by Starvation in Mice. In: Methods and Findings in Experimental and Clinical Pharmacology. 2003 ; Vol. 25, No. 8. pp. 601-606.
@article{836c5cd0ee964ef2b63c944dc7da8df2,
title = "The Changes of Hepatic Metallothionein Synthesis and the Hepatic Damage Induced by Starvation in Mice",
abstract = "Metallothionein (MT) is induced in the liver not only by heavy metals, but also by stress such as starvation. However the meaning of the induced MT during starvation has never been clear. In this study, we investigated the relationship between changes in hepatic MT synthesis and the hepatic damage that occurs during starvation. MT synthesis was assessed by measuring MT contents and the expression of the MT gene in the liver. The hepatic damage was assessed by measuring glutamic pyruvic transaminase (GPT) and glutamic oxaloacetic transaminase (GOT) activities in the serum. MT synthesis in the liver increased over the normal level by starvation, but decreased under the normal level by refeeding after starvation. Both GPT and GOT activities of the refeeding group were higher than those of the control group. However, MT synthesis increased by a subcutaneous injection with CdCl2 (1 mg Cd/kg) at the same time as refeeding after starvation. At this point, GOT activity decreased until it reached the normal level. MT synthesis decreased by refeeding after starvation, and from the results found in this study, we proposed the hypothesis that the liver damage caused by refeeding after starvation might be due to the decrease in the synthesis of a sufficient amount of MT induced by metals.",
keywords = "Hepatic damage, Metallothionein, Starvation",
author = "N. Sogawa and Sogawa, {C. A.} and H. Fukuoka and Y. Mukubo and T. Yoneyama and Y. Okano and H. Furuta and Kenji Onodera",
doi = "10.1358/mf.2003.25.8.778079",
journal = "Methods and Findings in Experimental and Clinical Pharmacology",
publisher = "Prous Science",
T1 - The Changes of Hepatic Metallothionein Synthesis and the Hepatic Damage Induced by Starvation in Mice
AU - Sogawa, N.
AU - Sogawa, C. A.
AU - Fukuoka, H.
AU - Mukubo, Y.
AU - Yoneyama, T.
AU - Okano, Y.
AU - Furuta, H.
AU - Onodera, Kenji
N2 - Metallothionein (MT) is induced in the liver not only by heavy metals, but also by stress such as starvation. However the meaning of the induced MT during starvation has never been clear. In this study, we investigated the relationship between changes in hepatic MT synthesis and the hepatic damage that occurs during starvation. MT synthesis was assessed by measuring MT contents and the expression of the MT gene in the liver. The hepatic damage was assessed by measuring glutamic pyruvic transaminase (GPT) and glutamic oxaloacetic transaminase (GOT) activities in the serum. MT synthesis in the liver increased over the normal level by starvation, but decreased under the normal level by refeeding after starvation. Both GPT and GOT activities of the refeeding group were higher than those of the control group. However, MT synthesis increased by a subcutaneous injection with CdCl2 (1 mg Cd/kg) at the same time as refeeding after starvation. At this point, GOT activity decreased until it reached the normal level. MT synthesis decreased by refeeding after starvation, and from the results found in this study, we proposed the hypothesis that the liver damage caused by refeeding after starvation might be due to the decrease in the synthesis of a sufficient amount of MT induced by metals.
AB - Metallothionein (MT) is induced in the liver not only by heavy metals, but also by stress such as starvation. However the meaning of the induced MT during starvation has never been clear. In this study, we investigated the relationship between changes in hepatic MT synthesis and the hepatic damage that occurs during starvation. MT synthesis was assessed by measuring MT contents and the expression of the MT gene in the liver. The hepatic damage was assessed by measuring glutamic pyruvic transaminase (GPT) and glutamic oxaloacetic transaminase (GOT) activities in the serum. MT synthesis in the liver increased over the normal level by starvation, but decreased under the normal level by refeeding after starvation. Both GPT and GOT activities of the refeeding group were higher than those of the control group. However, MT synthesis increased by a subcutaneous injection with CdCl2 (1 mg Cd/kg) at the same time as refeeding after starvation. At this point, GOT activity decreased until it reached the normal level. MT synthesis decreased by refeeding after starvation, and from the results found in this study, we proposed the hypothesis that the liver damage caused by refeeding after starvation might be due to the decrease in the synthesis of a sufficient amount of MT induced by metals.
KW - Hepatic damage
KW - Metallothionein
KW - Starvation
U2 - 10.1358/mf.2003.25.8.778079
DO - 10.1358/mf.2003.25.8.778079
JO - Methods and Findings in Experimental and Clinical Pharmacology
JF - Methods and Findings in Experimental and Clinical Pharmacology