Mucociliary transport and particle clearance in the human tracheobronchial tree.
Yu-CP; Hu-JP; Leikauf-G; Spektor-D; Lippmann-M
Faculty of Engineering and Applied Sciences, State University of New York at Buffalo, Buffalo, New York, 1988 Jun; :1-4
A compartmental model to describe mucociliary transport and particle clearance in the tracheobronchial trees was described. A method was proposed for determining the mucociliary transport rate as a function of the airway depth from the retention curve directly. Each airway generation was represented by an escalator. For Weibel's lung model there were 17 airway generations in the tracheobronchial tree. The subject performed a series of respiratory mechanical function tests prior to exposure to a monodisperse ferric-oxide aerosol tagged with technetium-99m. Thoracic retention measurements were started 5 minutes after inhalation and continued throughout the next 8 hours with an additional measurement taken the following day. Mucus velocities in millimeters/minute tended to decrease with the value increase of the generation number, but was nearly a constant between generation 7 and 14. The model was simple and appeared to describe the physical process well. Appropriate adjustments of the subject's airway dimensions were needed to further develop the model so that a single set of values of mucus velocity can be determined for several retention curves using different size particles and breathing patterns.
NIOSH-Grant; Airborne-particles; Dust-inhalation; Pulmonary-system-disorders; Mucous-membranes; Bronchial-asthma
Engineering Science S U N Y - at Buffalo Dept of Engineering Science Buffalo, N Y 14214
Final Grant Report
Grant-Number-R01-OH-00923
OEP
Faculty of Engineering and Applied Sciences, State University of New York at Buffalo, Buffalo, New York
State University of New York at Buffalo, Buffalo, New York