The potential of circadian realignment in rheumatoid arthritis
Rohit T. Rao, Kamau K. Pierre, Naomi Schlesinger, Ioannis P. Androulakis
Robert Wood Johnson Medical School (RWJMS), Medicine, Division of Rheumatology
School of Engineering, Biomedical Engineering
Brain Health Institute
Institute for Quantitative Biomedicine (IQB)
In this short review, we discuss evidence supporting the modulation of peripheral circadian systems as a therapeutic strategy for rheumatoid arthritis (RA). We first review the role of proinflammatory cytokines and oxidative stress, two of the primary mediators of chronic inflammation in RA, and their regulation by circadian clock machinery. We further highlight the role of environmental and metabolic signals in regulating the central and peripheral circadian clocks, with an emphasis on seasonal variations in photoperiod and rhythmic metabolic input, respectively. Finally, we hypothesize that the entrainment and realignment of peripheral clock rhythms have the ability to modulate these mediators, improving clinical outcomes in RA patients. Our discussion emphasizes the use of light therapy and time-restricted feeding for entraining peripheral clocks either via the entrainment of the central circadian clock in suprachiasmatic nuclei (SCN) or directly by uncoupling the peripheral circadian clocks from SCN. In doing so, we highlight the use of nonpharmacologic interventions as a potential strategy for improving clinical outcomes in chronic inflammatory conditions such as RA.
Critical reviews in biomedical engineering
https://doi.org/10.1615/critrevbiomedeng.2016018812
Circadian realignment
Proinflammatory cytokines
Time-restricted feeding
10.1615/critrevbiomedeng.2016018812
Dive into the research topics of 'The potential of circadian realignment in rheumatoid arthritis'. Together they form a unique fingerprint.
Circadian Clocks Medicine & Life Sciences 100%
Clocks Engineering & Materials Science 68%
Suprachiasmatic Nucleus Medicine & Life Sciences 50%
Inflammation Mediators Medicine & Life Sciences 25%
Photoperiod Medicine & Life Sciences 25%
Phototherapy Medicine & Life Sciences 24%
Oxidative stress Engineering & Materials Science 23%
Rao, R. T., Pierre, K. K., Schlesinger, N., & Androulakis, I. P. (2017). The potential of circadian realignment in rheumatoid arthritis. Critical reviews in biomedical engineering, 44(3), 177-191. https://doi.org/10.1615/critrevbiomedeng.2016018812
Rao, Rohit T. ; Pierre, Kamau K. ; Schlesinger, Naomi et al. / The potential of circadian realignment in rheumatoid arthritis. In: Critical reviews in biomedical engineering. 2017 ; Vol. 44, No. 3. pp. 177-191.
@article{6070a2ad306b42f6bba9457df226331c,
title = "The potential of circadian realignment in rheumatoid arthritis",
abstract = "In this short review, we discuss evidence supporting the modulation of peripheral circadian systems as a therapeutic strategy for rheumatoid arthritis (RA). We first review the role of proinflammatory cytokines and oxidative stress, two of the primary mediators of chronic inflammation in RA, and their regulation by circadian clock machinery. We further highlight the role of environmental and metabolic signals in regulating the central and peripheral circadian clocks, with an emphasis on seasonal variations in photoperiod and rhythmic metabolic input, respectively. Finally, we hypothesize that the entrainment and realignment of peripheral clock rhythms have the ability to modulate these mediators, improving clinical outcomes in RA patients. Our discussion emphasizes the use of light therapy and time-restricted feeding for entraining peripheral clocks either via the entrainment of the central circadian clock in suprachiasmatic nuclei (SCN) or directly by uncoupling the peripheral circadian clocks from SCN. In doing so, we highlight the use of nonpharmacologic interventions as a potential strategy for improving clinical outcomes in chronic inflammatory conditions such as RA.",
keywords = "Circadian realignment, Proinflammatory cytokines, Rheumatoid arthritis, Seasonality, Time-restricted feeding",
author = "Rao, {Rohit T.} and Pierre, {Kamau K.} and Naomi Schlesinger and Androulakis, {Ioannis P.}",
note = "Funding Information: The authors gratefully acknowledge financial support from National Institutes of Health grant no. GM024211. Publisher Copyright: {\textcopyright} 2016 Begell House, Inc.",
doi = "10.1615/critrevbiomedeng.2016018812",
journal = "Critical Reviews in Biomedical Engineering",
publisher = "Begell House Inc.",
Rao, RT, Pierre, KK, Schlesinger, N & Androulakis, IP 2017, 'The potential of circadian realignment in rheumatoid arthritis', Critical reviews in biomedical engineering, vol. 44, no. 3, pp. 177-191. https://doi.org/10.1615/critrevbiomedeng.2016018812
The potential of circadian realignment in rheumatoid arthritis. / Rao, Rohit T.; Pierre, Kamau K.; Schlesinger, Naomi et al.
In: Critical reviews in biomedical engineering, Vol. 44, No. 3, 2017, p. 177-191.
T1 - The potential of circadian realignment in rheumatoid arthritis
AU - Rao, Rohit T.
AU - Pierre, Kamau K.
AU - Schlesinger, Naomi
AU - Androulakis, Ioannis P.
N1 - Funding Information: The authors gratefully acknowledge financial support from National Institutes of Health grant no. GM024211. Publisher Copyright: © 2016 Begell House, Inc.
N2 - In this short review, we discuss evidence supporting the modulation of peripheral circadian systems as a therapeutic strategy for rheumatoid arthritis (RA). We first review the role of proinflammatory cytokines and oxidative stress, two of the primary mediators of chronic inflammation in RA, and their regulation by circadian clock machinery. We further highlight the role of environmental and metabolic signals in regulating the central and peripheral circadian clocks, with an emphasis on seasonal variations in photoperiod and rhythmic metabolic input, respectively. Finally, we hypothesize that the entrainment and realignment of peripheral clock rhythms have the ability to modulate these mediators, improving clinical outcomes in RA patients. Our discussion emphasizes the use of light therapy and time-restricted feeding for entraining peripheral clocks either via the entrainment of the central circadian clock in suprachiasmatic nuclei (SCN) or directly by uncoupling the peripheral circadian clocks from SCN. In doing so, we highlight the use of nonpharmacologic interventions as a potential strategy for improving clinical outcomes in chronic inflammatory conditions such as RA.
AB - In this short review, we discuss evidence supporting the modulation of peripheral circadian systems as a therapeutic strategy for rheumatoid arthritis (RA). We first review the role of proinflammatory cytokines and oxidative stress, two of the primary mediators of chronic inflammation in RA, and their regulation by circadian clock machinery. We further highlight the role of environmental and metabolic signals in regulating the central and peripheral circadian clocks, with an emphasis on seasonal variations in photoperiod and rhythmic metabolic input, respectively. Finally, we hypothesize that the entrainment and realignment of peripheral clock rhythms have the ability to modulate these mediators, improving clinical outcomes in RA patients. Our discussion emphasizes the use of light therapy and time-restricted feeding for entraining peripheral clocks either via the entrainment of the central circadian clock in suprachiasmatic nuclei (SCN) or directly by uncoupling the peripheral circadian clocks from SCN. In doing so, we highlight the use of nonpharmacologic interventions as a potential strategy for improving clinical outcomes in chronic inflammatory conditions such as RA.
KW - Circadian realignment
KW - Proinflammatory cytokines
KW - Rheumatoid arthritis
KW - Seasonality
KW - Time-restricted feeding
U2 - 10.1615/critrevbiomedeng.2016018812
DO - 10.1615/critrevbiomedeng.2016018812
JO - Critical Reviews in Biomedical Engineering
JF - Critical Reviews in Biomedical Engineering
Rao RT, Pierre KK, Schlesinger N, Androulakis IP. The potential of circadian realignment in rheumatoid arthritis. Critical reviews in biomedical engineering. 2017;44(3):177-191. doi: 10.1615/critrevbiomedeng.2016018812