Estring
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Estring Side Effects
Estring | Estradiol Vaginal Ring has some very serious adverse side effects associated with it, such as:
Cardiovascular side effects such as heart disease and heart attacks
Endocrine metabolic side effects such as breast cancer and hypercalcemia, or abnormal amounts of calcium in the blood
Gastrointestinal side effects such as disorders of the gallbladder
Hematological side effects such as venous thromboembolism, when a blood clot forms inside a vein
Immunological side effects such as anaphylaxis, a deadly allergic reaction
Neurological side effects such as stroke and dementia
Ophthalmic side effects such as thrombosis of retinal vein, when a blood clot forms in the eye
Reproductive side effects such as malignant tumor of the inner membrane of the uterus, and ovarian cancer
Respiratory side effects such as pulmonary embolism, or the blockage of the main artery of the lung
More common and less severe adverse side effects from this drug include:
Cardiovascular side effects such as fluid accumulation, or edema
Dermatological side effects such as application site irritation, discoloration of the skin, more hair at site of application, loss of scalp hair, redness of the skin, and itching
Endocrine metabolic side effects such as weight gain and increased body fluid retention
Gastrointestinal side effects such as bloating, nausea and vomiting
Neurological side effects such as headache
Psychiatric side effects such as depression
Reproductive side effects such as breast tenderness, menstrual disorders, vaginal discharge, pain or swelling of the breast, vaginal discomfort, and withdrawal bleeding
Warnings & Recalls for Estring
Black Box Warning
Estring | Estradiol Vaginal Ring has an associated "black box" warning attached to it that denotes the risk of endometrial cancer for women taking this drug. Cardiovascular risks and endometrial cancer risks are heightened when taking certain estrogens.
The contraindications associated with this drug that hinder a patient's ability to take it include:
Undiagnosed vaginal bleeding
Known or suspected breast cancer
Known or suspected estrogen-dependent tumor
Active deep vein thrombosis
Active stroke
Patients who've had heart attacks
Known liver dysfunction
Known hypersensitivity to this drug
Who Should Not Take This Drug
The patients with the following preexisting conditions should never take Estring | Estradiol Vaginal Ring. These include:
Addition of progestins to therapy
Arterial vascular disease
Children should be kept away from this drug
Cardiac or renal dysfunctions
Residual post-hysterectomy
Gallbladder disease
Hereditary angioedema
Preexisting hypertriglyceridemia
Preexisting hypoparathyroidism
Impaired liver function or jaundice
Men are usually dissuaded from taking this drug
Prolongation of therapy with this drug
Sunscreen use
Patients who take tartrazine
Estring Treatment and Use
Estring | Estradiol Vaginal Ring is used to treat vaginal dryness, burning, itching, difficult or painful urination and the sudden urge to urinate in women who are experiencing menopause. Its official FDA-labeled indications are for treating:
Abnormal vasomotor function in women with menopause
Atrophy of the vulva
Advanced cancer of prostate which is androgen-dependent
Decreased estrogen levels
Urethral atrophy
Post-menopausal osteoporosis
Its non-FDA labeled indications are for:
Male-to-female gender transition
Menstrual migraine
Estring | Estradiol Vaginal Ring is marketed and manufactured by Pfizer. This drug comes in the form of a ring to line into the vaginal wall.
Please refer to the "warnings and recalls" tab to get the "black box" warning information for this drug.
How This Drug Works
The mechanism of action for Estring | Estradiol Vaginal Ring is that estrogens are known to regulate the transcription of limited numbers of genes and bind to nuclear receptors in tissues that are responsive to estrogen. Estrogens are also known to modulate pituitary secretions of gonadotropins and other hormones by the way of a negative feedback mechanism which reduces levels of these hormones that are present in menopausal women.
Other Names for Estring
Estradiol Vaginal Ring
Lawsuits & Legal Information for Estring