Cheng-Wei Lin
Department of Biochemistry and Molecular Cell Biology
International Ph.D. Program for Cell Therapy and Regeneration Medicine
Emailcwlin@tmu.edu.tw
Development of mutlifunctional nanoparticles self-assembled from trimethyl chitosan and fucoidan for enhanced oral delivery of insulin
Tsai, L. C., Chen, C. H., Lin, C. W., Ho, Y. C. & Mi, F. L., Apr 1 2019, In : International Journal of Biological Macromolecules. 126, p. 141-150 10 p.
Medical problems
Glucosidases
Metastatic colorectal cancer rewrites metabolic program through a Glut3-YAP-dependent signaling circuit
Kuo, C. C., Ling, H. H., Chiang, M. C., Chung, C. H., Lee, W. Y., Chu, C. Y., Wu, Y. C., Chen, C. H., Lai, Y. W., Tsai, I. L., Cheng, C. H. & Lin, C. W., Jan 1 2019, In : Theranostics. 9, 9, p. 2526-2540 15 p.
Reduction in MnSOD promotes the migration and invasion of squamous carcinoma cells
Fan, J. J., Hsu, W. H., Hung, H. H., Zhang, W. J., A Lee, Y. L., Chen, K. C., Chu, C. Y., Ko, T. P., Lee, M. T., Lin, C. W. & Cheng, C. H., Apr 1 2019, In : International Journal of Oncology. 54, 5, p. 1639-1650 12 p.
Luteolin
The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells
Yang, C. E., Lee, W. Y., Cheng, H. W., Chung, C. H., Mi, F. L. & Lin, C. W., Apr 1 2019, In : Chemico-Biological Interactions. 302, p. 28-35 8 p.
Activation of fibroblasts by nicotine promotes the epithelial-mesenchymal transition and motility of breast cancer cells
Chen, P. C., Lee, W. Y., Ling, H. H., Cheng, C. H., Chen, K. C. & Lin, C. W., Jan 1 2018, (Accepted/In press) In : Journal of Cellular Physiology.
Flavonoids Luteolin and Quercetin Inhibit RPS19 and contributes to metastasis of cancer cells through c-Myc reduction
Chen, K. C., Hsu, W. H., Ho, J. Y., Lin, C. W., Chu, C. Y., Kandaswami, C. C., Lee, M. T. & Cheng, C. H., Jan 1 2018, (Accepted/In press) In : Journal of Food and Drug Analysis.
Antroquinonol, a ubiquinone derivative from the mushroom antrodia camphorata, inhibits colon cancer stem cell-like properties: Insights into the molecular mechanism & inhibitory targets
Lin, H. C., Lin, M. H., Liao, J. H., Wu, T. H., Lee, T. H., Mi, F. L., Wu, C. H., Chen, K. C., Cheng, C. H. & Lin, C. W., 2017, In : Journal of Agricultural and Food Chemistry. 65, 1, p. 51-59 9 p.
Antrodia
Taiwanofungus camphoratus
Ubiquinone
ubiquinones
Development of a new type of multifunctional fucoidan-based nanoparticles for anticancer drug delivery
Lu, K. Y., Li, R., Hsu, C. H., Lin, C. W., Chou, S. C., Tsai, M. L. & Mi, F. L., Jun 1 2017, In : Carbohydrate Polymers. 165, p. 410-420 11 p.
Protamines
Dietary flavonoids, luteolin and quercetin, inhibit invasion of cervical cancer by reduction of UBE2S through epithelial-mesenchymal transition signaling
Lin, T. H., Hsu, W. H., Tsai, P. H., Huang, Y. T., Lin, C. W., Chen, K. C., Tsai, I. H., Kandaswami, C. C., Huang, C. J., Chang, G. D., Lee, M. T. & Cheng, C. H., Apr 1 2017, In : Food and Function. 8, 4, p. 1558-1568 11 p.
uterine cervical neoplasms
Elevation of YAP promotes the epithelial-mesenchymal transition and tumor aggressiveness in colorectal cancer
Ling, H. H., Kuo, C. C., Lin, B. X., Huang, Y. H. & Lin, C. W., Jan 1 2017, In : Experimental Cell Research. 350, 1, p. 218-225 8 p.
Identification of IGF-1-enhanced cytokine expressions targeted by miR-181d in glioblastomas via an integrative miRNA/mRNA regulatory network analysis
Ho, K. H., Chen, P. H., Hsi, E., Shih, C. M., Chang, W. C., Cheng, C. H., Lin, C. W. & Chen, K. C., Dec 1 2017, In : Scientific Reports. 7, 1, 732.
Somatomedins
MicroRNAs
Panobinostat sensitizes KRAS-mutant non-small-cell lung cancer to gefitinib by targeting TAZ
Lee, W. Y., Chen, P. C., Wu, W. S., Wu, H. C., Lan, C. H., Huang, Y. H., Cheng, C. H., Chen, K. C. & Lin, C. W., 2017, (Accepted/In press) In : International Journal of Cancer.
Histone Deacetylase Inhibitors
panobinostat
Podocalyxin-like protein 1 regulates TAZ signaling and stemness properties in colon cancer
Lee, W. Y., Kuo, C. C., Lin, B. X., Cheng, C. H., Chen, K. C. & Lin, C. W., Oct 1 2017, In : International Journal of Molecular Sciences. 18, 10, 2047.
The CHAC1-inhibited Notch3 pathway is involved in temozolomide-induced glioma cytotoxicity
Chen, P. H., Shen, W. L., Shih, C-M., Ho, K. H., Cheng, C-H., Lin, C-W., Lee, C-C., Liu, A. J. & Chen, K-C., Apr 1 2017, In : Neuropharmacology. 116, p. 300-314 15 p.
Poly(ADP-ribose) Polymerases
The microRNA-302b-inhibited insulin-like growth factor-binding protein 2 signaling pathway induces glioma cell apoptosis by targeting nuclear factor IA
Lee, C. C., Chen, P. H., Ho, K. H., Shih, C. M., Cheng, C. H., Lin, C. W., Cheng, K. T., Liu, A. J. & Chen, K. C., Mar 1 2017, In : PLoS One. 12, 3, e0173890.
Insulin-Like Growth Factor Binding Protein 2
insulin-like growth factor binding proteins
The Inhibition of microRNA-128 on IGF-1-Activating mTOR Signaling involves in temozolomide-Induced glioma cell apoptotic death
Chen, P. H., Cheng, C-H., Shih, C-M., Ho, K. H., Lin, C-W., Lee, C-C., Liu, A. J., Chang, C-K. & Chen, K-C., Nov 1 2016, In : PLoS One. 11, 11, e0167096.
Insulin-Like Growth Factor I
The miR-204-3p-targeted IGFBP2 pathway is involved in xanthohumol-induced glioma cell apoptotic death
Chen, P. H., Chang, C. K., Shih, C. M., Cheng, C. H., Lin, C. W., Lee, C. C., Liu, A. J., Ho, K. H. & Chen, K. C., Nov 1 2016, In : Neuropharmacology. 110, p. 362-375 14 p.
Humulus
An anti-EpCAM antibody EpAb2-6 for the treatment of colon cancer
Liao, M. Y., Lai, J. K., Kuo, M. Y. P., Lu, R. M., Lin, C. W., Cheng, P. C., Liang, K. H. & Wu, H. C., 2015, In : Oncotarget. 6, 28, p. 24947-24968 22 p.
Antroquinonol from Antrodia Camphorata suppresses breast tumor migration/invasion through inhibiting ERK-AP-1- and AKT-NF-κB-dependent MMP-9 and epithelial-mesenchymal transition expressions
Lee, W. T., Li, Z-H., Cheng, C. H., Chen, K. C., Chen, Y. C. & Lin, C. W., Apr 1 2015, In : Food and Chemical Toxicology. 78, p. 33-41 9 p.
gelatinase B
Transcription Factor AP-1
CD44-specific nanoparticles for redox-triggered reactive oxygen species production and doxorubicin release
Lin, C-W., Lu, K. Y., Wang, S. Y., Sung, H. W. & Mi, F-L., Oct 19 2015, (Accepted/In press) In : Acta Biomaterialia.
Effect of Grape Seed Proanthocyanidin-Gelatin Colloidal Complexes on Stability and in Vitro Digestion of Fish Oil Emulsions
Su, Y. R., Tsai, Y. C., Hsu, C. H., Chao, A. C., Lin, C. W., Tsai, M. L. & Mi, F. L., Nov 17 2015, In : Journal of Agricultural and Food Chemistry. 63, 46, p. 10200-10208 9 p.
grape seeds
in vitro digestion
Repositioning antipsychotic chlorpromazine for treating colorectal cancer by inhibiting sirtuin 1
Lee, W. Y., Lee, W. T., Cheng, C. H., Chen, K. C., Chou, C. M., Chung, C. H., Sun, M. S., Cheng, H. W., Ho, M. N. & Lin, C. W., 2015, In : Oncotarget. 6, 29, p. 27580-27595 16 p.
Sirtuin 1
JNK Mitogen-Activated Protein Kinases
RPS12 increases the invasiveness in cervical cancer activated by c-Myc and inhibited by the dietary flavonoids luteolin and quercetin
Lin, C. W., Lai, G. M., Chen, K. C., Lin, T. H., Fan, J. J., Hsu, R. L., Chou, C. M., Lin, C. M., Kandaswami, C. C., Lee, M. T. & Cheng, C. H., Dec 1 2015, In : Journal of Functional Foods. 19, p. 236-247 12 p.
Delivery of berberine using chitosan/fucoidan-taurine conjugate nanoparticles for treatment of defective intestinal epithelial tight junction barrier
Wu, S. J., Don, T. M., Lin, C-W. & Mi, F-L., Nov 24 2014, In : Marine Drugs. 12, 11, p. 5677-5697 21 p.
FRET-based dual-emission and pH-responsive nanocarriers for enhanced delivery of protein across intestinal epithelial cell barrier
Lu, K. Y., Lin, C. W., Hsu, C. H., Ho, Y. C., Chuang, E-T., Sung, H. W. & Mi, F. L., Oct 22 2014, In : ACS Applied Materials and Interfaces. 6, 20, p. 18275-18289 15 p.
Angiogenic Proteins
Induction of ROS-independent JNK-activation-mediated apoptosis by a novel coumarin-derivative, DMAC, in human colon cancer cells
Lin, M. H., Cheng, C. H., Chen, K. C., Lee, W. T., Wang, Y. F., Xiao, C. Q. & Lin, C. W., Jul 25 2014, In : Chemico-Biological Interactions. 218, p. 42-49 8 p.
Coumarins
MicroRNA-302b-inhibited E2F3 transcription factor is related to all trans retinoic acid-induced glioma cell apoptosis
Chen, P. H., Shih, C. M., Chang, W. C., Cheng, C. H., Lin, C. W., Ho, K. H., Su, P. C. & Chen, K. C., 2014, In : Journal of Neurochemistry. 131, 6, p. 731-742 12 p.
E2F3 Transcription Factor
Podocalyxin-like 1 is associated with tumor aggressiveness and metastatic gene expression in human oral squamous cell carcinoma
Lin, C. W., Sun, M. S. & Wu, H. C., 2014, In : International Journal of Oncology. 45, 2, p. 710-718 9 p.
Cortactin
Podocalyxin-like 1 promotes invadopodia formation and metastasis through activation of Rac1/Cdc42/cortactin signaling in breast cancer cells
Lin, C. W., Sun, M. S., Liao, M. Y., Chung, C. H., Chi, Y. H., Chiou, L. T., Yu, J., Lou, K. L. & Wu, H. C., Nov 1 2014, In : Carcinogenesis. 35, 11, p. 2425-2435 11 p.
Paxillin
Tea catechins-cross-linked methylcellulose active films for inhibition of light irradiation and lipid peroxidation induced β-carotene degradation
Yu, S. H., Tsai, M. L., Lin, B. X., Lin, C. W. & Mi, F. L., Nov 4 2014, In : Food Hydrocolloids. 44, p. 491-505 15 p.
Catechin
The induction of heme oxygenase-1 suppresses heat shock protein 90 and the proliferation of human breast cancer cells through its byproduct carbon monoxide
Lee, W. Y., Chen, Y-C., Shih, C-M., Lin, C-M., Cheng, C-H., Chen, K-C. & Lin, C-W., Jan 1 2014, In : Toxicology and Applied Pharmacology. 274, 1, p. 55-62 8 p.
HSP90 Heat-Shock Proteins
Heme Oxygenase-1
Byproducts
CHC promotes tumor growth and angiogenesis through regulation of HIF-1α and VEGF signaling
Tung, K. H., Lin, C. W., Kuo, C. C., Li, L. T., Kuo, Y. H., Lin, C. W. & Wu, H. C., Apr 30 2013, In : Cancer Letters. 331, 1, p. 58-67 10 p.
Clathrin Heavy Chains
Epithelial cell adhesion molecule regulates tumor initiation and tumorigenesis via activating reprogramming factors and epithelial-mesenchymal transition gene expression in colon cancer
Lin, C. W., Liao, M. Y., Lin, W. W., Wang, Y. P., Lu, T. Y. & Wu, H. C., Nov 16 2012, In : Journal of Biological Chemistry. 287, 47, p. 39449-39459 11 p.
Cell Adhesion Molecules
12-O-tetradecanoylphorbol-13-acetate-induced invasion/migration of glioblastoma cells through activating PKCα/ERK/NF-κB-dependent MMP-9 expression
Lin, C. W., Shen, S. C., Chien, C. C., Yang, L. Y., Shia, L. T. & Chen, Y. C., 2010, In : Journal of Cellular Physiology. 225, 2, p. 472-481 10 p.
Tetradecanoylphorbol Acetate
Matrix Metalloproteinases
Contribution of reactive oxygen species to migration/invasion of human glioblastoma cells U87 via ERK-dependent COX-2/PGE2 activation
Chiu, W-T., Shen, S-C., Chow, J-M., Lin, C-W., Shia, L. T. & Chen, Y-C., Jan 2010, In : Neurobiology of Disease. 37, 1, p. 118-129 12 p.
Cyclooxygenase 2
Dinoprostone
Cobalt protoporphyrin inhibition of lipopolysaccharide or lipoteichoic acid-induced nitric oxide production via blocking c-Jun N-terminal kinase activation and nitric oxide enzyme activity
Lin, H. Y., Shen, S-C., Lin, C-W., Wu, M-S. & Chen, Y-C., Jul 15 2009, In : Chemico-Biological Interactions. 180, 2, p. 202-210 9 p.
Zinc protoporphyrin inhibition of lipopolysaccharide-, lipoteichoic acid-, and peptidoglycan-induced nitric oxide production through stimulating iNOS protein ubiquitination
Chow, J-M., Lin, H. Y., Shen, S-C., Wu, M-S., Lin, C-W., Chiu, W-T., Lin, C-H. & Chen, Y-C., Jun 15 2009, In : Toxicology and Applied Pharmacology. 237, 3, p. 357-365 9 p.
Peptidoglycan
Differential apoptotic effect of wogonin and nor-wogonin via stimulation of ROS production in human leukemia cells
Chow, J-M., Huang, G. C., Shen, S-C., Wu, C. Y., Lin, C-W. & Chen, Y-C., Apr 1 2008, In : Journal of Cellular Biochemistry. 103, 5, p. 1394-1404 11 p.
Hydroxyl Radical
HL-60 Cells
Heme oxygenase-1 inhibits breast cancer invasion via suppressing the expression of matrix metalloproteinase-9
Lin, C. W., Shen, S. C., Hou, W. C., Yang, L. Y. & Chen, Y. C., 2008, In : Molecular Cancer Therapeutics. 7, 5, p. 1195-1206 12 p.
Matrix Metalloproteinase 9
MCF-7 Cells
Quercetin inhibition of tumor invasion via suppressing PKCδ/ERK/ AP-1-dependent matrix metalloproteinase-9 activation in breast carcinoma cells
Lin, C. W., Hou, W. C., Shen, S. C., Juan, S. H., Ko, C. H., Wang, L. M. & Chen, Y. C., 2008, In : Carcinogenesis. 29, 9, p. 1807-1815 9 p.
Proto-Oncogene Proteins c-jun
Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression
Lin, H. Y., Shen, S. C., Lin, C. W., Yang, L. Y. & Chen, Y. C., Jul 2007, In : Biochimica et Biophysica Acta - Molecular Cell Research. 1773, 7, p. 1073-1086 14 p.
Gossypol reduction of tumor growth through ROS-dependent mitochondria pathway in human colorectal carcinoma cells
Ko, C. H., Shen, S. C., Yang, L. Y., Lin, C. W. & Chen, Y. C., Oct 15 2007, In : International Journal of Cancer. 121, 8, p. 1670-1679 10 p.
IGF-I plus E2 induces proliferation via activation of ROS-dependent ERKs and JNKs in human breast carcinoma cells
Lin, C. W., Yang, L. Y., Shen, S. C. & Chen, Y. C., Sep 2007, In : Journal of Cellular Physiology. 212, 3, p. 666-674 9 p.
Phosphotransferases
Wogonin but not Nor-wogonin inhibits lipopolysaccharide and lipoteichoic acid-induced iNOS gene expression and NO production in macrophages
Huang, G. C., Chow, J-M., Shen, S-C., Yang, L-Y., Lin, C-W. & Chen, Y-C., Aug 2007, In : International Immunopharmacology. 7, 8, p. 1054-1063 10 p.
Nitric Oxide Synthase Type II
Macrophages
Baicalein inhibition of oxidative-stress-induced apoptosis via modulation of ERKs activation and induction of HO-1 gene expression in rat glioma cells C6
Chen, Y-C., Chow, J-M., Lin, C-W., Wu, C. Y. & Shen, S-C., Oct 15 2006, In : Toxicology and Applied Pharmacology. 216, 2, p. 263-273 11 p.
Lipopolysaccharide plus 12-o-tetradecanoylphorbol 13-acetate induction of migration and invasion of glioma cells in vitro and in vivo: Differential inhibitory effects of flavonoids
Shen, S. C., Lin, C. W., Lee, H. M., Chien, L. L. & Chen, Y. C., 2006, In : Neuroscience. 140, 2, p. 477-489 13 p.
Metalloproteases
Quercetin inhibition of ROS-dependent and -independent apoptosis in rat glioma C6 cells
Chen, T. J., Jeng, J. Y., Lin, C. W., Wu, C. Y. & Chen, Y. C., Jun 1 2006, In : Toxicology. 223, 1-2, p. 113-126 14 p.
Contact Cheng-Wei Lin