MAPK13
Mitogen-activated protein kinase 13
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an importan ...more
Q5U4A5open_in_new
Q6FI46open_in_new
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MAP kinase 13open_in_new
MAPK13open_in_new
PRKM13
SAPK4
MAPK 13
MAPK-13
p38delta
hub protein
interacting protein
PANTHER Classes Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Mitogen-activated Protein Kinase 13
DTO ClassesProtein / Kinase / Protein Kinase / Cmgc Group / Mapk Family / P38 Subfamily / Mitogen-activated Protein Kinase 13
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