Cholestasis beyond the neonatal and infancy periods
Racha Khalaf, Claudia Phen, Sara Karjoo, Michael Wilsey
Cholestasis results from impairment in the excretion of bile, which may be due to mechanical obstruction of bile flow or impairment of excretion of bile components into the bile canaliculus. When present, cholestasis warrants prompt diagnosis and treatment. The differential diagnosis of cholestasis beyond the neonatal period is broad and includes congenital and acquired etiologies. It is imperative that the clinician differentiates between intrahepatic and extrahepatic origin of cholestasis. Treatment may be supportive or curative and depends on the etiology. Recent literature shows that optimal nutritional and medical support also plays an integral role in the management of pediatric patients with chronic cholestasis. This review will provide a broad overview of the pathophysiology, diagnostic approach, and management of cholestasis beyond the neonatal and infancy periods.
Pediatric Gastroenterology, Hepatology and Nutrition
https://doi.org/10.5223/pghn.2016.19.1.1
Alagille syndrome
Biliary cysts
Conjugated hyperbilirubinemia
Hepatolenticular degeneration
10.5223/pghn.2016.19.1.1
Fingerprint Dive into the research topics of 'Cholestasis beyond the neonatal and infancy periods'. Together they form a unique fingerprint.
Cholestasis Medicine & Life Sciences
Bile Medicine & Life Sciences
Extrahepatic Cholestasis Medicine & Life Sciences
Bile Canaliculi Medicine & Life Sciences
Nutritional Support Medicine & Life Sciences
Khalaf, R., Phen, C., Karjoo, S., & Wilsey, M. (2016). Cholestasis beyond the neonatal and infancy periods. Pediatric Gastroenterology, Hepatology and Nutrition, 19(1), 1-11. https://doi.org/10.5223/pghn.2016.19.1.1
Cholestasis beyond the neonatal and infancy periods. / Khalaf, Racha; Phen, Claudia; Karjoo, Sara; Wilsey, Michael.
In: Pediatric Gastroenterology, Hepatology and Nutrition, Vol. 19, No. 1, 01.03.2016, p. 1-11.
Khalaf, R, Phen, C, Karjoo, S & Wilsey, M 2016, 'Cholestasis beyond the neonatal and infancy periods', Pediatric Gastroenterology, Hepatology and Nutrition, vol. 19, no. 1, pp. 1-11. https://doi.org/10.5223/pghn.2016.19.1.1
Khalaf R, Phen C, Karjoo S, Wilsey M. Cholestasis beyond the neonatal and infancy periods. Pediatric Gastroenterology, Hepatology and Nutrition. 2016 Mar 1;19(1):1-11. https://doi.org/10.5223/pghn.2016.19.1.1
Khalaf, Racha ; Phen, Claudia ; Karjoo, Sara ; Wilsey, Michael. / Cholestasis beyond the neonatal and infancy periods. In: Pediatric Gastroenterology, Hepatology and Nutrition. 2016 ; Vol. 19, No. 1. pp. 1-11.
@article{8a7cc7b92a3444fd9ec814bbef25f33c,
title = "Cholestasis beyond the neonatal and infancy periods",
abstract = "Cholestasis results from impairment in the excretion of bile, which may be due to mechanical obstruction of bile flow or impairment of excretion of bile components into the bile canaliculus. When present, cholestasis warrants prompt diagnosis and treatment. The differential diagnosis of cholestasis beyond the neonatal period is broad and includes congenital and acquired etiologies. It is imperative that the clinician differentiates between intrahepatic and extrahepatic origin of cholestasis. Treatment may be supportive or curative and depends on the etiology. Recent literature shows that optimal nutritional and medical support also plays an integral role in the management of pediatric patients with chronic cholestasis. This review will provide a broad overview of the pathophysiology, diagnostic approach, and management of cholestasis beyond the neonatal and infancy periods.",
keywords = "Alagille syndrome, Biliary cysts, Cholelithiasis, Cholestasis, Conjugated hyperbilirubinemia, Hepatitis, Hepatolenticular degeneration, Jaundice, Pruritus",
author = "Racha Khalaf and Claudia Phen and Sara Karjoo and Michael Wilsey",
note = "Funding Information: The authors wish to thank Raquel Hernandez MD, MPH, Director of the Office of Medical Education at Johns Hopkins All Children's Hospital and Ruben Quiros MD, Professor and Chief of Pediatric Gastroenterology at the University of Nebraska Medical Center for their critical review of the manuscript, along with David Troendle MD, Division of Pediatric Gastroenterology at the UT Southwestern Medical Center, for the courtesy of Fig. 2 and 3.",
doi = "10.5223/pghn.2016.19.1.1",
journal = "Pediatric Gastroenterology, Hepatology and Nutrition",
publisher = "Korean Society of Pediartic Gastroenterology, Hepatology and Nutrition",
T1 - Cholestasis beyond the neonatal and infancy periods
AU - Khalaf, Racha
AU - Phen, Claudia
AU - Karjoo, Sara
AU - Wilsey, Michael
N1 - Funding Information: The authors wish to thank Raquel Hernandez MD, MPH, Director of the Office of Medical Education at Johns Hopkins All Children's Hospital and Ruben Quiros MD, Professor and Chief of Pediatric Gastroenterology at the University of Nebraska Medical Center for their critical review of the manuscript, along with David Troendle MD, Division of Pediatric Gastroenterology at the UT Southwestern Medical Center, for the courtesy of Fig. 2 and 3.
N2 - Cholestasis results from impairment in the excretion of bile, which may be due to mechanical obstruction of bile flow or impairment of excretion of bile components into the bile canaliculus. When present, cholestasis warrants prompt diagnosis and treatment. The differential diagnosis of cholestasis beyond the neonatal period is broad and includes congenital and acquired etiologies. It is imperative that the clinician differentiates between intrahepatic and extrahepatic origin of cholestasis. Treatment may be supportive or curative and depends on the etiology. Recent literature shows that optimal nutritional and medical support also plays an integral role in the management of pediatric patients with chronic cholestasis. This review will provide a broad overview of the pathophysiology, diagnostic approach, and management of cholestasis beyond the neonatal and infancy periods.
AB - Cholestasis results from impairment in the excretion of bile, which may be due to mechanical obstruction of bile flow or impairment of excretion of bile components into the bile canaliculus. When present, cholestasis warrants prompt diagnosis and treatment. The differential diagnosis of cholestasis beyond the neonatal period is broad and includes congenital and acquired etiologies. It is imperative that the clinician differentiates between intrahepatic and extrahepatic origin of cholestasis. Treatment may be supportive or curative and depends on the etiology. Recent literature shows that optimal nutritional and medical support also plays an integral role in the management of pediatric patients with chronic cholestasis. This review will provide a broad overview of the pathophysiology, diagnostic approach, and management of cholestasis beyond the neonatal and infancy periods.
KW - Alagille syndrome
KW - Biliary cysts
KW - Cholelithiasis
KW - Cholestasis
KW - Conjugated hyperbilirubinemia
KW - Hepatitis
KW - Hepatolenticular degeneration
KW - Jaundice
KW - Pruritus
U2 - 10.5223/pghn.2016.19.1.1
DO - 10.5223/pghn.2016.19.1.1
JO - Pediatric Gastroenterology, Hepatology and Nutrition
JF - Pediatric Gastroenterology, Hepatology and Nutrition