Radiosynovectomy of the ankle in hemophilic arthropathy: effectiveness of samarium-153 and yttrium-90
Hugo Maia Rodrigues Department of Orthopedics, Rheumatology and Traumatology, College of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil. https://orcid.org/0000-0003-0401-2968
Giuliane Sarmet Moreira Damas dos Santos Portilho de Castro Department of Orthopedics, Rheumatology and Traumatology, College of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil. https://orcid.org/0000-0002-8388-5849
Marcela dos Santos Martins Department of Orthopedics, Rheumatology and Traumatology, College of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Mauro Cesar Mattos e Dinato Department of Orthopedics, Rheumatology and Traumatology, College of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil. https://orcid.org/0000-0001-6572-1771
Glenda Feldberg Andrade Pinto Hematology and Hemotherapy Center, University of Campinas (UNICAMP), Campinas, SP, Brazil. https://orcid.org/0000-0001-7091-9918
Janaina Bosso da Silva Ricciardi Hematology and Hemotherapy Center, University of Campinas (UNICAMP), Campinas, SP, Brazil. https://orcid.org/0000-0002-1822-0576
Emerson Taro Inoue Sakuma Department of Anesthesiology, Oncology and Radiology, College of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Allan de Oliveira Santos Department of Anesthesiology, Oncology and Radiology, College of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil. https://orcid.org/0000-0002-9192-6946
Margareth Castro Ozelo Hematology and Hemotherapy Center, University of Campinas (UNICAMP), Campinas, SP, Brazil. https://orcid.org/0000-0001-5938-0675
Rodrigo Gonçalves Pagnano Department of Orthopedics, Rheumatology and Traumatology, College of Medical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil. https://orcid.org/0000-0002-6064-2027
Ankle, Arthropathy, Hemophilia, Synovectomy, Radioisotopes
Objective: Evaluate the effect of radiosynovectomy of the ankle with samarium-153 and yttrium-90 in hemophilic arthropathy through the possible reduction of hemarthrosis, analyzing complications, adverse effects, and the need for complementary therapies. Methods: Radiosynovectomy of the ankle in 15 hemophilic patients was analyzed retrospectively and followed between January 2008 and December 2021. The analysis was performed through patients' medical records and diaries to quantify hemarthrosis that occurred six months before and six months after the procedure. Clinical follow-up and evaluation of outcomes were also analyzed. Results: Eighteen radiosynovectomies of the ankle were performed in 15 patients with a mean follow-up of 124 months. A reduction in episodes of haemarthrosis has been demonstrated within six months (p<0.001). There were no adverse effects or complications in the short and long term. Approximately 61.1% of the patients did not require complementary therapies afterward. Conclusion: The study demonstrated that radiosynovectomy of the ankle with samarium-153 and yttrium-90 in hemophilic patients is effective and safe. There was a decreased frequency of hemarthrosis, less need for complementary procedures, and no complications and adverse effects. Level of Evidence IV, Case Series.
Maia Rodrigues, H. ., Sarmet Moreira Damas dos Santos Portilho de Castro, G. ., dos Santos Martins, M., Cesar Mattos e Dinato, M., Feldberg Andrade Pinto, G., Bosso da Silva Ricciardi , J., Taro Inoue Sakuma, E., de Oliveira Santos, A., Castro Ozelo, M., & Gonçalves Pagnano, R. (2022). Radiosynovectomy of the ankle in hemophilic arthropathy: effectiveness of samarium-153 and yttrium-90. Journal of the Foot & Ankle, 16(3), 259–263. https://doi.org/10.30795/jfootankle.2022.v16.1651