The Kainic Acid Models of Temporal Lobe Epilepsy
eNeuro. 2021 Apr 9;8(2):ENEURO.0337-20.2021. doi: 10.1523/ENEURO.0337-20.2021. Print 2021 Mar-Apr.
Evgeniia Rusina 1 , Christophe Bernard 1 , Adam Williamson 2 3
1 Institute de Neurosciences des Systèmes, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1106, Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Systèmes, Marseille, France.
2 Institute de Neurosciences des Systèmes, Institut National de la Santé et de la Recherche Médicale, Unité Mixte de Recherche 1106, Aix Marseille Univ, Inserm, INS, Institut de Neurosciences des Systèmes, Marseille, France adam.williamson@univ-amu.fr.
3 Laboratory of Organic Electronics, Campus Norrköping, Linköping University, Norrköping 602 21, Sweden.
DOI: 10.1523/ENEURO.0337-20.2021
Experimental models of epilepsy are useful to identify potential mechanisms of epileptogenesis, seizure genesis, comorbidities, and treatment efficacy. The kainic acid (KA) model is one of the most commonly used. Several modes of administration of KA exist, each producing different effects in a strain-, species-, gender-, and age-dependent manner. In this review, we discuss the advantages and limitations of the various forms of KA administration (systemic, intrahippocampal, and intranasal), as well as the histologic, electrophysiological, and behavioral outcomes in different strains and species. We attempt a personal perspective and discuss areas where work is needed. The diversity of KA models and their outcomes offers researchers a rich palette of phenotypes, which may be relevant to specific traits found in patients with temporal lobe epilepsy.
Keywords: EEG; hippocampus; kainic acid; mice models of temporal lobe epilepsy.
Copyright © 2021 Rusina et al.
Epilepsy, Temporal Lobe* / chemically induced
Kainic Acid