Research ArticleNEUROPHARMACOLOGY
1-(3′,4′-Dichloro-2-fluoro[1,1′-biphenyl]-4-yl)-cyclopropanecarboxylic Acid (CHF5074), a Novel γ-Secretase Modulator, Reduces Brain β-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease without Causing Peripheral Toxicity
Bruno P. Imbimbo, Elda Del Giudice, Davide Colavito, Antonello D'Arrigo, Maurizio Dalle Carbonare, Gino Villetti, Fabrizio Facchinetti, Roberta Volta, Vladimiro Pietrini, Maria F. Baroc, Lutgarde Serneels, Bart De Strooper and Alberta Leon
Journal of Pharmacology and Experimental Therapeutics December 2007, 323 (3) 822-830; DOI: https://doi.org/10.1124/jpet.107.129007
Bruno P. Imbimbo
Elda Del Giudice
Davide Colavito
Antonello D'Arrigo
Maurizio Dalle Carbonare
Gino Villetti
Fabrizio Facchinetti
Roberta Volta
Vladimiro Pietrini
Maria F. Baroc
Lutgarde Serneels
Bart De Strooper
Alberta Leon
vol. 323 no. 3 822-830
https://doi.org/10.1124/jpet.107.129007
Received July 20, 2007
Accepted September 24, 2007
Published online November 15, 2007.
Earlier version (September 25, 2007 - 11:08).
You are viewing the most recent version of this article.
Bruno P. Imbimbo,
Elda Del Giudice,
Davide Colavito,
Antonello D'Arrigo,
Maurizio Dalle Carbonare,
Gino Villetti,
Fabrizio Facchinetti,
Roberta Volta,
Vladimiro Pietrini,
Maria F. Baroc,
Lutgarde Serneels,
Bart De Strooper and
Research & Development, Chiesi Farmaceutici, Parma, Italy (B.P.I., G.V., F.F., R.V.); Research & Innovation, Padova, Italy (E.D.G., D.C., A.D., M.D.C., A.L.); Department of Neurosciences, Neurology Section, University of Parma, Parma, Italy (V.P., M.F.B.); and Department for Molecular and Developmental Genetics, Vlaams Instituut voor Biotechnologie and Center for Human Genetics, Katholieke Universiteit Leuven, Leuven, Belgium (L.S., B.D.S.)
Address correspondence to:
Dr. Bruno P. Imbimbo, Research & Development, Chiesi Farmaceutici, via Palermo 26/A, 43100 Parma, Italy. E-mail: b.imbimbo{at}chiesigroup.com
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Journal of Pharmacology and Experimental Therapeutics December 1, 2007, 323 (3) 822-830; DOI: https://doi.org/10.1124/jpet.107.129007
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