Duke Scholarly Works
Enhancing the Hodgkin-Huxley Equations: Simulations Based on the First Publication in the Biophysical Journal.
Moore, JW
Repository Usage Stats
The experiments in the Cole and Moore article in the first issue of the Biophysical Journal provided the first independent experimental confirmation of the Hodgkin-Huxley (HH) equations. A log-log plot of the K current versus time showed that raising the HH variable n to the sixth power provided the best fit to the data. Subsequent simulations using n(6) and setting the resting potential at the in vivo value simplifies the HH equations by eliminating the leakage term. Our article also reported that the K current in response to a depolarizing step to ENa was delayed if the step was preceded by a hyperpolarization. While the interpretation of this phenomenon in the article was flawed, subsequent simulations show that the effect completely arises from the original HH equations.
Decapodiformes
History, 20th Century
Membrane Potentials
Models, Neurological
Published Version (Please cite this version)
10.1016/j.bpj.2015.08.008
Publication Info
Moore, JW (2015). Enhancing the Hodgkin-Huxley Equations: Simulations Based on the First Publication in the Biophysical Journal. Biophys J, 109(7). pp. 1317-1320. 10.1016/j.bpj.2015.08.008. Retrieved from http://hdl.handle.net/10161/11524.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
Articles written by Duke faculty are made available through the campus open access policy. For more information see: Duke Open Access Policy
Rights for Collection: Scholarly Articles
Search DukeSpace