New York City is one of my all-time favorite photography locations. I've lived in the area for around a year and spent many weekends in the city walking around with my camera. One of the most photographed buildings - besides Time Square and the Empire State Building - is Rockefeller Center. When you google for "Rockefeller Center" and choose the 'image' tab on the left, you get over 2,000,000 hits. The majority of the images show the Christmas tree or the Ice skating rink.
While there might be lots of pictures shot from the location I chose, I haven't seen many good pictures which were shot at night while it was raining. I anyway think that you get the best possible light when shooting New York at twilight during rainy weather.
Here is my take at Rockefeller Center with the Atlas Statue at night in the rain.
The reason for choosing a very low ISO of 100 was that I wanted to get light-trails of the passing cars in the frame. I was leaning against a lamp post to stabilize myself and the camera. Using that method you can shoot rather long exposures without a tripod and still get a sharp image.