EJG and TWS contributed equally.
WAB and CYP contributed equally.
Contributors Guarantor of the article: EJdG and TS. Development of study concept and design: EJE, PCFS, WAB and CYP. Acquisition of data: EJdG, EJE, TJG and BM collected the data. Analysis and interpretation of data: EJdG, TS, JEB, HD, CB, WAB and CYP. Statistical analysis: JEB and HD. Drafting of manuscript: EJdG, TS, JEB, HD, WAB and CYP. Critical revision of the manuscript for important intellectual content: all authors.
Funding This study was financially supported by a grant from The Netherlands Organisation for Health Research and Development. The funder had no role in the conduct and interpretation of the trial.
Competing interests EJdG, TS, JEB, HvD, EJE, TJG, BM, CB, PCFS and WAB declare no conflict of interest. CYP declares a grant from Takeda, Dr Falk Pharma and Abbvie, advisory board fees from Takeda and GSK, as well as speaker's fees from Takeda, Abbvie, Ferring, MSD and Dr. Falk Pharma. GRAMD'H has served as advisor for Abbvie, Ablynx, Amakem, AM Pharma, Avaxia, Biogen, Bristol Meiers Squibb, Boerhinger Ingelheim, Celgene, Celltrion, Cosmo, Covidien/Medtronics, Ferring, DrFalk Pharma, Engene, Galapagos, Genentech/Roche, Gilead, Glaxo Smith Kline, Hospira, Immunic, Johnson and Johnson, Lycera, Medimetrics, Millenium/Takeda, Mitsubishi Pharma, Merck Sharp Dome, Mundipharma, Novonordisk, Otsuka, Pfizer, Prometheus laboratories/Nestle, Protagonist, Receptos, Robarts Clinical Trials, Salix, Sandoz, Setpoint, Shire, Teva, Tigenix, Tillotts, Topivert, Versant and Vifor and received speaker fees from Abbvie, Biogen, Ferring, Johnson and Johnson, Merck Sharp Dome, Mundipharma, Norgine, Pfizer, Shire, Millenium/Takeda, Tillotts and Vifor. AH declares an advisory board fee from MSD.
Ethics approval The medical ethics committee at the Amsterdam UMC, location Meibergdreef 9, Amsterdam, Netherlands and the corresponding committees in all participating centres in the Netherlands and the UK.
Collaborators LIRIC study group: Janindra Warusavitarne; Ad A Van Bodegraven; Menno A Brink; Esther CJ Consten; Bart A Van Wagensveld; Marno CM Rijk; Rogier MPH Crolla; Casper G Noomen; Alexander PJ Houdijk; Rosalie C Mallant; Maarten Boom; Willem A Marsman; Hein B Stockmann; A Jeroen De Groof; Karlien Bruin; John Maring; Theo van Ditzhuijsen; Hubert Prins; Jan van den Brande; Paul Kingma; Anna van Geloven; Nanne de Boer; Donald van der Peet; Jeroen Jansen; Michael Gerhards; Janneke van der Woude; Ruud Schouten; Bas Oldenburg; Richard van Hillegersberg; Rachel West; Guido Mannaerts; Marcel Spanier; Ernst Jan Spillenaar Bilgen; Rob Lieverse; Edwin van der Zaag; Annekatrien Depla; Arnold van de Laar; Clemens Bolwerk; Hans Brouwer; Nofel Mahmmod; Eric Hazebroek; Juda Vecht; Robert Pierik; Gerard Dijkstra; Sijbrand Hofker; Tessa Uiterwaal; Quirijn Eijsbouts; Liekele Oostenbrug; Meindert Sosef; Djuna Cahen; Sjoerd van der Werff; Andreas Marinelli; Job Peters; Huib Cense; Nynke Talstra; Pritesh Morar.