1. aspirin, phenacetin, and caffeine: a compound formerly used in headache and cold remedies.
In normal hepatocytes, activation of the [beta]-catenin gene is transient, followed by rapid degradation of the [beta]-catenin protein, which is facilitated by a set of genes, including axins, glycogen S-kinase 3 (GSK3), and adenomatosis polyposis coli (APC).
Classic familial adenomatous polyposis (FAP) (6) is an autosomal dominant inherited disease caused by germline mutations in the adenomatosis polyposis coli (APC) (7) tumor suppressor gene.