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Chlorpheniramine may interfere with the ability of the liver to remove phenytoin from the body. This may cause an increase in the side effects of phenytoin including drowsiness, dizziness, headaches, and blurred vision. Other more serious or potentially life-threatening side effects include anemia due to a decrease in red blood cells, repeated infections due to a decrease in white blood cells, and damage to the liver. If these drugs are used at the same time, your doctor may want to make sure that you are not getting too much phenytoin and adjust the dose of either drug if needed. Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems.
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