A painter's undiagnosed illness begins to affect his work after his girlfriend notices the grotesqueness of his paintings. He is brought to Princeton-Plainsboro Hospital, though he claims that he is getting better. House grows suspicious when he learns that the painter was fearful of a test involving the injection of a dye. It is later revealed that he is on three separate drug trials, which he was hiding from his girlfriend. Meanwhile, House continues to use Lucas to obtain information about his team and to learn more about Cuddy's personal life.