The purpose of the present invention is to provide a nanosheet which can maintain a planar shape, and a production method thereof. A multilayer structure sheet which comprises a nanosheet layer and an elastic layer and which has a rolled structure, and a production method thereof, are provided.
Polymer ultra-thin film (hereinafter, ' nano-sheets' referred to) of a polymer such as polylactic acid is several hundred - several tens nm and a sheet having a thickness of, from its thin profile and flexibility, the shape of the skin or the surface of the organ, even without an adhesive can be adhered by van der Waals force and surface tension.
This feature the nanoparticles from the sheet, and the affected the incision wound as a protective material used to stick (non-patent document 1, 2). Is further in recent years, nanosheets, in endoscopic surgery can be used as the material conveying, the transplantation of the cells into the living tissue (retina lower) used as a graft substrate such as surgery, the use of in vivo have been developed in a narrow environment, has been studied (non-patent document 3-5).
On the other hand, nano-sheets is thin, because it is pliable, when bent downward or in a liquid, to recover the planar shape not to itself. Therefore, suppresses deformation of the nano-sheets, and maintain the planar shape, are attached to the site of interest is not easy. Further the site of interest in the living body is in an environment where the narrow, directly operated by the nanosheet is impossible, while maintain the planar shape becomes more difficult to be attached.
Therefore, the nanosheets in the art while controlling/maintain the planar shape, conveniently, they are attached to the site of interest to enable new means been desired earnestly.