He was a missionary for 35 years in the Amazon area of South America. Primarily he worked with other artists, such as Doug Chafey and Bill Webb, but he sometimes did his own artwork. He also did a cartoon series for Biblical Evangelist magazine. In addition to his cartoons and comics, Best wrote a number of books for young people including some new Sherlock Holmes stories wherein Dr. Watson quotes a Scripture he had heard from "our friend Charlie Spurgeon.