Mucormycosis is a serious infection and needs to be treated with prescription antifungal medication, usually amphotericin B, posaconazole or isavuconazole. These medications are given through a vein (amphotericin B, posaconazole, isavuconazole) or by mouth (posaconazole, isavuconazole). Often, mucormycosis requires surgery to cut away the infected tissue.