Read the following excerpt from a US court opinion:
```
Court appreciates that there is a declining market for the PRRS vaccine which may limit the duration of Boehringer’s patent. Moreover, Schering has informed the Court that Bayer Corporation and other companies now market competing vaccines which will also affect the PRRS market. Therefore, it appears that the PRRS vaccine market is more competitive now such that the ability to compensate Boehringer for its losses will be more difficult to determine. These limitations on the commercial success of Boehringer’s patent and the effective duration of its patent, even if not caused by Schering’s conduct, is an indication that Boehringer’s Patent has a shortened duration and thus, Boehringer’s need to enforce its right to exclusivity is more acute at this time. See Polymer, 103 F.3d at 975 ; Bell & Howell Document Management Products
```
What is the most suitable continuation to the opinion? Your options are:
A. holding that a movant that clearly establishes likelihood of success on the merits receives the benefit of a presumption of irreparable harm
B. holding that evidence that the infringer was not the principal or the sole cause of the patentees lost sales does not rebut the presumption of irreparable harm
C. holding that a party who can show a significant risk of irreparable harm has demonstrated that the harm is not speculative
D. holding that the district court erred when it failed to consider the presumption of irreparable harm
E. holding that the threat of irreparable harm must be immediate
Reply with [A, B, C, D, E] only.