However, using KiNG [39] we manually determined that single-peptide rotation angles from 25u to +15u of the N3 peptide could help optimize the H-bonding angle of its backbone amide to the N-cap sidechain H-bonding angle and were viable in terms of sterics, Ramachandran dihedrals [23], and t angles; therefore we included such a rotation in increments of 1u.
Sample text:```Because previous studies indicated that hexapeptides bind the junction core (29, 32), we tested two junctions, one with an AT-rich core and the other with a GC-rich core (Fig.```
Sample intent: result
Sample text:```Because previous studies indicated that hexapeptides bind the junction core (29, 32), we tested two junctions, one with an AT-rich core and the other with a GC-rich core (Fig.```
Sample intent: result



Sample text:```A rook pivoting scheme as in [3] and [11] can be implemented for tridiagonal matrices, but a full rook scheme for general banded matrices would probably lead to a ”chasing” scheme as in [5] or [15] .```
Sample intent: background



Sample text:```Our genealogy, based on many alleles but only the first exon of bindin, is not entirely consistent with that of McCartney and Lessios (2004), based on fewer alleles but incorporating the entire molecule.```
Sample intent: result



Sample text:```U-box domain does not depend on zinc binding to keep its stability, but have evolved instead networks of hydrogen bonds and salt bridges formed by the corresponding residues at metal ligand positions (Hatakeyama et al., 2001; Nordquist et al., 2010; Wiborg et al., 2008).```
Sample intent: method



Sample text:```We screened for potential TF binding sites using STAMP [59], with the motifs’ position weight matrices (PWMs) retrieved from the TRANSFAC database [60].```
Sample intent: background
Sample text:```The sequence of intermediates in the hR photocycle and their interconversions have been the subject of numerous studies (Va´ró et al., 1995a, b; Hazemoto et al., 1984; Zimányi and Lanyi, 1989a, b; Zima´nyi et al., 1989; Spencer and Dewey, 1990; Ames et al., 1992; Dioumaev and Braiman, 1997a).```
Sample intent: method



Sample text:```A number of studies have been published recently, which analyze the location, orientation, and identity ofmacromolecular complexes, based on the outcome of template-matching (Brandt et al., 2009; Ortiz et al., 2010).```
Sample intent: method



Sample text:```We screened for potential TF binding sites using STAMP [59], with the motifs’ position weight matrices (PWMs) retrieved from the TRANSFAC database [60].```
Sample intent: background



Sample text:```This study supports the theory of a tumor origin from multipotential progenitor cells.(14) Reports of the Ki67 labeling index have demonstrated great variety.```
Sample intent: result



Sample text:```They play an important
role in stabilizing coordination geometries, adjusting ligand donor strengths, and mediating proton transfer reactions (Span et al. 2017; Holm et al. 1996; Makris et al. 2007).```
Sample intent: method



Sample text:```U-box domain does not depend on zinc binding to keep its stability, but have evolved instead networks of hydrogen bonds and salt bridges formed by the corresponding residues at metal ligand positions (Hatakeyama et al., 2001; Nordquist et al., 2010; Wiborg et al., 2008).```
Sample intent: method



Sample text:```For seeking the optimal value of Wh of the sub-problems which corresponds to the h-th level, we can solve the problem by the smoothing proximal gradient (SPG) method [6] fortunately.```
Sample intent: background



Sample text:```It is a weak base (pKa 7.8) with poor oral bioavailability thus necessitating administration of relatively high doses (300–450 mg/kg body weight in preclinical models) for optimal therapeutic benefits (Aneja et al., 2007; Ke et al., 2000; Ye et al., 1998).```
Sample intent: method



Sample text:```Because previous studies indicated that hexapeptides bind the junction core (29, 32), we tested two junctions, one with an AT-rich core and the other with a GC-rich core (Fig.```
Sample intent: result



Sample text:```Illustra PuReTaq ReadyTo-Go PCR beads (0.5 ml tubes, GE healthcare) were used to amplify DTL, SLFN5, TRIM47, WRAP53 and CHN1 transcripts (denaturing at 94uC for 30 s, annealing at 58uC for 1 min and elongation at 72uC for 2 min, 25‚Äì35 cycles).```
Sample intent: background