In a previous report, when the dose of celecoxib was increased up to 400 mg/kg in rats, the Cmax was reported to be 17.7 ¬µM (Paulson et al., 1999), which was comparable with our results.
Sample text:```It is a weak base (pKa 7.8) with poor oral bioavailability thus necessitating administration of relatively high doses (300–450 mg/kg body weight in preclinical models) for optimal therapeutic benefits (Aneja et al., 2007; Ke et al., 2000; Ye et al., 1998).```
Sample intent: method
Sample text:```Consistent with our results, there was no significant association of 25(OH)D and mortality in a 3-year follow-up study of 230 Chinese patients with a median peritoneal dialysis duration of 26 months [7].```
Sample intent: result



Sample text:```Effects of CACC inhibitors were analyzed by the following four-parameter logistic function: y min (max min)/[1 (x/IC50) Hill slope], where min and max are the bottom and top of the curve, respectively, IC50 is the concentration of half inhibition of block, and the Hill slope is a reflection of the steepness of the curve.```
Sample intent: background



Sample text:```Other studies suggest that altering affinity to FcRn might alter the bioavailability of mAbs (Deng et al., 2010; Deng et al., 2012), and SC bioavailability appears lower in FcRn-deficient mice as compared to wild type animals (Wang et al., 2008).```
Sample intent: method



Sample text:```Our results confi rm previous studies that reached the same conclusion (Boushey et al 1994; Vermeulen et al 2000; Till et al 2005; Marcucci et al 2005).```
Sample intent: result



Sample text:```Our results show that after 4 h of thiotepa treatment, the level of expression of anti-apoptotic Bcl-2 was not changed; this confirms the results of a previous study [25].```
Sample intent: result
Sample text:```Our results confi rm previous studies that reached the same conclusion (Boushey et al 1994; Vermeulen et al 2000; Till et al 2005; Marcucci et al 2005).```
Sample intent: result



Sample text:```In addition, consistent with the result of our preclinical study, recent clinical study showed that alectinib was also highly active against ALK-positive NSCLC patients after treatment with crizotinib [21].```
Sample intent: result



Sample text:```In line with previous results (3, 19, 20, 30), we found that during muscle contraction ERK1/2 phosphorylation was increased and was not affected by CaMKII inhibition.```
Sample intent: result



Sample text:```The inter-relationships between K1, K1O and anticoagulants in dogs and humans have been previously investigated [25, 26].```
Sample intent: background



Sample text:```Effects of CACC inhibitors were analyzed by the following four-parameter logistic function: y min (max min)/[1 (x/IC50) Hill slope], where min and max are the bottom and top of the curve, respectively, IC50 is the concentration of half inhibition of block, and the Hill slope is a reflection of the steepness of the curve.```
Sample intent: background



Sample text:```The GITT model performs better than an empirical lag-time model [17], however, its predicted profiles tend to underestimate Cmax, which, if consistent, may suggest confounding systematic bias or invalid assumptions.```
Sample intent: background



Sample text:```Our results show that after 4 h of thiotepa treatment, the level of expression of anti-apoptotic Bcl-2 was not changed; this confirms the results of a previous study [25].```
Sample intent: result



Sample text:```Consistent with our results, there was no significant association of 25(OH)D and mortality in a 3-year follow-up study of 230 Chinese patients with a median peritoneal dialysis duration of 26 months [7].```
Sample intent: result



Sample text:```Group 3: mice were anesthetized in a Plexiglas chamber with 3% isoflurane in air for 25 min (after the desired concentration was reached) twice daily, as described previously (12); 0.```
Sample intent: background



Sample text:```A linear relationship between erythrocyte GSH-Px and whole blood Se concentration was already described in camel [3, 8].```
Sample intent: method