Furthermore, MAPK has been shown to phosphorylate both Raf-1 (36) and MEK (37), and a cyclic relationship that generates amplification or inhibitory feed back loops has been suggested among Raf-1, MEK, and MAPK (5, 6).
Sample text:```Several studies have shown that a major function of PP2A is downregulation of the Ras/MAP kinase pathway (2, 3, 22, 30, 50, 51, 53).```
Sample intent: method
Sample text:```ly), which have been originally identified as molecules activated by growth factor-stimulation of fibroblusts, are key kinases in the intracellular signal transduction pathways (1-6).```
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Sample text:```Determination of MAP
 During a preliminary experiment, MAP was determined using the same procedure as has been previously described (Gamet et al. 1993).```
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Sample text:```In line with previous results (3, 19, 20, 30), we found that during muscle contraction ERK1/2 phosphorylation was increased and was not affected by CaMKII inhibition.```
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Sample text:```Several studies have shown that a major function of PP2A is downregulation of the Ras/MAP kinase pathway (2, 3, 22, 30, 50, 51, 53).```
Sample intent: method



Sample text:```In line with our results, several previous studies demonstrated the anti-proliferative effect of PPARs agonists in several cell types [11-15].```
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Sample text:```Our results further confirm previous findings on the differential regulatory mechanisms for Hoxa3 and Hoxb3 expression in r5 and r6 by kreisler (Manzanares et al., 1997, 1999a,b, 2001).```
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Sample text:```Intriguingly, using MPRs-deficient MEF cells, mouse and human CLN5 have been shown to reach lysosomes in an MPRindependent manner [12].```
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Sample text:```These are in keeping with earlier studies on the steadystate response (2, 5, 8), step-function response, (3, 5, 6, 14) and sinusoidal response ( 14) of the various vascular beds.```
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Sample text:```The inter-relationships between K1, K1O and anticoagulants in dogs and humans have been previously investigated [25, 26].```
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Sample text:```c-Jun-N-Terminal inhibitory kinase JIK and TRAF2 to the stimulated ER stress sensor IRE-1, where TRAF2 can activate ASK-1, an upstream activating kinase of JNK (2) activation of caspase 12, which is released from its```
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Sample text:```This study supports the theory of a tumor origin from multipotential progenitor cells.(14) Reports of the Ki67 labeling index have demonstrated great variety.```
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Sample text:```Determination of MAP
 During a preliminary experiment, MAP was determined using the same procedure as has been previously described (Gamet et al. 1993).```
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Sample text:```…Lamirande and Gagnon (2002)
Sulindac sulphid Ras-Raf Interaction – 100 de Lamirande and Gagnon (2002) ZM336372 Raf, competitive inhibition 0.07– 0.007 3 de Lamirande and Gagnon (2002) PD98059 prevents MEK activation by Raf 4–50 50 de Lamirande and Gagnon (2002) U126 inhibits activated MEK…```
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Sample text:```In line with previous results (3, 19, 20, 30), we found that during muscle contraction ERK1/2 phosphorylation was increased and was not affected by CaMKII inhibition.```
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Sample text:```We used the stepwise multiple linear regression that accounts for repeated measurements in the same dog (4) first to test whether there was a difference among values for resistances and for elastances between control and emphysema at each mean Paw, considering the entire range of f and VT of forcing.```
Sample intent: background