On the other hand, MPCCs metabolized low turnover drugs (less than or equal to 1 mL/min/kg) significantly faster in the serum-free medium than in vivo, and thus use of reported fu values significantly improved the accuracy of clearance predictions, as also observed previously (Blanchard et al., 2005; Smith et al., 2012).
Sample text:```Other studies suggest that altering affinity to FcRn might alter the bioavailability of mAbs (Deng et al., 2010; Deng et al., 2012), and SC bioavailability appears lower in FcRn-deficient mice as compared to wild type animals (Wang et al., 2008).```
Sample intent: method
Sample text:```Intriguingly, using MPRs-deficient MEF cells, mouse and human CLN5 have been shown to reach lysosomes in an MPRindependent manner [12].```
Sample intent: background



Sample text:```MtrF has been proposed either to shuttle antimicrobials to the pump for export or to help stabilize one or more components of the efflux pump (56, 57).```
Sample intent: method



Sample text:```Basal ATP concentrations in the bulk medium of unstimulated CFs are low, but the concentrations of released nucleotides near the cell surface may be sufficient to activate adjacent P2Y receptors and contribute to basal signaling (48, 49).```
Sample intent: method



Sample text:```Consistent with our results, there was no significant association of 25(OH)D and mortality in a 3-year follow-up study of 230 Chinese patients with a median peritoneal dialysis duration of 26 months [7].```
Sample intent: result



Sample text:```Two days after transfection, cells were harvested and D2 activity was measured in lysates using HPLC, as described previously (20).```
Sample intent: background
Sample text:```Basal ATP concentrations in the bulk medium of unstimulated CFs are low, but the concentrations of released nucleotides near the cell surface may be sufficient to activate adjacent P2Y receptors and contribute to basal signaling (48, 49).```
Sample intent: method



Sample text:```A linear relationship between erythrocyte GSH-Px and whole blood Se concentration was already described in camel [3, 8].```
Sample intent: method



Sample text:```Intriguingly, using MPRs-deficient MEF cells, mouse and human CLN5 have been shown to reach lysosomes in an MPRindependent manner [12].```
Sample intent: background



Sample text:```Other studies suggest that altering affinity to FcRn might alter the bioavailability of mAbs (Deng et al., 2010; Deng et al., 2012), and SC bioavailability appears lower in FcRn-deficient mice as compared to wild type animals (Wang et al., 2008).```
Sample intent: method



Sample text:```Effects of CACC inhibitors were analyzed by the following four-parameter logistic function: y min (max min)/[1 (x/IC50) Hill slope], where min and max are the bottom and top of the curve, respectively, IC50 is the concentration of half inhibition of block, and the Hill slope is a reflection of the steepness of the curve.```
Sample intent: background



Sample text:```In the subsequent studies, Yoshida et al. (2004b) and Ishii et al. (2004) confirmed the reversibility of 2,6-dihydroxybenzoate decarboxylase of Rhizobium sp. strain MTP-10005 and R.radiobacter WU-0108, respectively.```
Sample intent: result



Sample text:```Previous studies revealed that acylcarnitines were elevated early after APAP treatment and that their elevation was indicative of mitochondrial damage and dysfunction.(15,19) In the present study these observations were confirmed, as palmitoylcarnitine was elevated by toxic doses of APAP and maintained at normal levels (compared with untreated controls) by Wy-14,643 pretreatment.```
Sample intent: result



Sample text:```Laboratory parameters considered in this study were those already found significantly different between early PMF and WHO-ET: Hb (g/dL), WBC (3109/L), PLT (3109/L), and LDH (mU/mL).```
Sample intent: background



Sample text:```Signaling promotes MPO surface expression
Although ion channel clustering provides a route to understanding field detection, it does not account for the metabolic changes noted in our previous studies (Kindzelskii and Petty 2000).```
Sample intent: method



Sample text:```Two days after transfection, cells were harvested and D2 activity was measured in lysates using HPLC, as described previously (20).```
Sample intent: background