Second, although a clinically relevant dose of fentanyl was administered and used in routine clinical practice and in previous research studies in health (1,2) and HF (3,22), which resulted in significant physiological changes in this and previous studies likely through partial blockade of afferent feedback, the actual degree of blockade remains unknown.
Sample text:```Secondly, this effect was shown to be selectively due to CCK2 activation (Ladurelle et al. 1997) through mechanisms involving δ-opioid (Daugé et al. 1999) and D1-dopamine receptors (Ladurelle et al. 1993) that could be blocked by the selective antagonists naltrindole (a δ antagonist), and SCH23,390.```
Sample intent: method
Sample text:```hemicholinium-3, a depletor of endogenous acetylcholine (Parikh and Sarter, 2006); (ii) by enhancing cholinergic tone with AF-DX384, a selective M2/M4 autoreceptor antagonist, that blocks the self-inhibitory mechanism by which acetylcholine regulates its own release and (iii) by selectively blocking M1 muscarinic receptors, key modulators of both LTD and LTP (Calabresi et al., 2000; Wang et al., 2006; Bonsi et al., 2008).```
Sample intent: method



Sample text:```The admission assessment included determining the risk factors for cerebral infarction,13,14 clinical ischemic stroke category (National Institute of Neurological Disorders and Stroke1), and disease severity using the National Institutes of Health Stroke Scale.15
545
Abbreviations
AF = Atrial fibrillation
LAA = Left atrial appendage
LAA eV = LAA emptying flow velocity
LAD = Left atrial dimension
LAWV = LAA peak wall velocity
ROC = Receiver operating characteristic
SEC = Spontaneous echocardiographic contrast
TEE = Transesophageal echocardiography
TTE = Transthoracic echocardiography
We defined patients who had no histories of AF and no documented AF on continuous electrocardiographic monitoring during hospitalization as the sinus rhythm group, patients who had histories of AF before admission and/or continuously documented AF on continuous electrocardiographic monitoring during hospitalization as having chronic AF, and patients who had AF at admission and recovered to normal sinus rhythm during hospitalization and/or showed sinus rhythm at admission and documented transient AF on continuous electrocardiographic monitoring during hospitalization as having paroxysmal AF.```
Sample intent: background



Sample text:```The inter-relationships between K1, K1O and anticoagulants in dogs and humans have been previously investigated [25, 26].```
Sample intent: background



Sample text:```Consistent with our results, there was no significant association of 25(OH)D and mortality in a 3-year follow-up study of 230 Chinese patients with a median peritoneal dialysis duration of 26 months [7].```
Sample intent: result



Sample text:```If charge is screened at the site of blocker interaction, rates of dissociation are unaffected (Anderson et al., 1988).```
Sample intent: method
Sample text:```If charge is screened at the site of blocker interaction, rates of dissociation are unaffected (Anderson et al., 1988).```
Sample intent: method



Sample text:```Similarly, in a study on 60 subjects, blinks were measured at the beginning and end of a working day (Caffier et al., 2003). Although no significant difference between alert and drowsy phases was found, a slightly decreased blink rate during drowsy phase was reported. However, these results contradict the findings of Morris and Miller (1996) about the efficiency of F in a moving base-flight simulator with 10 sleep-deprived pilots.```
Sample intent: result



Sample text:```These results corroborate studies that have demonstrated an enhancement of other types of reward with Dz-specific agonists [6,17,21,52].```
Sample intent: result



Sample text:```hemicholinium-3, a depletor of endogenous acetylcholine (Parikh and Sarter, 2006); (ii) by enhancing cholinergic tone with AF-DX384, a selective M2/M4 autoreceptor antagonist, that blocks the self-inhibitory mechanism by which acetylcholine regulates its own release and (iii) by selectively blocking M1 muscarinic receptors, key modulators of both LTD and LTP (Calabresi et al., 2000; Wang et al., 2006; Bonsi et al., 2008).```
Sample intent: method



Sample text:```Basal ATP concentrations in the bulk medium of unstimulated CFs are low, but the concentrations of released nucleotides near the cell surface may be sufficient to activate adjacent P2Y receptors and contribute to basal signaling (48, 49).```
Sample intent: method



Sample text:```Group 3: mice were anesthetized in a Plexiglas chamber with 3% isoflurane in air for 25 min (after the desired concentration was reached) twice daily, as described previously (12); 0.```
Sample intent: background



Sample text:```These are in keeping with earlier studies on the steadystate response (2, 5, 8), step-function response, (3, 5, 6, 14) and sinusoidal response ( 14) of the various vascular beds.```
Sample intent: result



Sample text:```The ¬¨¬µ-opioid receptor agonist morphine also induced inhibitory effects in both assays, in accordance with previous reports describing the opiate-mediated inhibition of the BSL evoked in mice by excitatory amino acids and neurokinins (Aanonsen et al. 1987; Takahasi et al. 1987; Wilcox 1988).```
Sample intent: result



Sample text:```Other studies suggest that altering affinity to FcRn might alter the bioavailability of mAbs (Deng et al., 2010; Deng et al., 2012), and SC bioavailability appears lower in FcRn-deficient mice as compared to wild type animals (Wang et al., 2008).```
Sample intent: method



Sample text:```Secondly, this effect was shown to be selectively due to CCK2 activation (Ladurelle et al. 1997) through mechanisms involving δ-opioid (Daugé et al. 1999) and D1-dopamine receptors (Ladurelle et al. 1993) that could be blocked by the selective antagonists naltrindole (a δ antagonist), and SCH23,390.```
Sample intent: method