This results in overproduction of superoxide radicals (44,45) leading to accelerated degradation of proteins, lipids and DNA, a process which may be exacerbated by superoxide radicals interaction with NO (46), and finally in neuronal death (36,37).
Sample text:```Although the time-constants of the learning window used in this study were much shorter than those reported for hippocampal neurons by Bi and Poo [27] (viz.```
Sample intent: background
Sample text:```The effect of O2 appears to be mediated at least in part by prolyl 4-hydroxylation of Skp1, because elevated O2 levels are required by phyA – and Skp1-overexpression strains, and lower O2 is required by PhyA overexpression and Skp1B cells [10,24].```
Sample intent: method



Sample text:```In line with our results, several previous studies demonstrated the anti-proliferative effect of PPARs agonists in several cell types [11-15].```
Sample intent: result



Sample text:```Intriguingly, using MPRs-deficient MEF cells, mouse and human CLN5 have been shown to reach lysosomes in an MPRindependent manner [12].```
Sample intent: background



Sample text:```Our results show that after 4 h of thiotepa treatment, the level of expression of anti-apoptotic Bcl-2 was not changed; this confirms the results of a previous study [25].```
Sample intent: result



Sample text:```Dead individuals were removed, surface sterilized with 5.2% sodium hypochlorite, rinsed twice with sterile water, and plated on potato dextrose agar to confirm that mortality was due to infection by M. anisopliae (Rosengaus et al. 1998).```
Sample intent: background
Sample text:```Induction of C1qa in the CNS promotes synapse elimination and synaptic dysfunction during development, neurodegenerative diseases such as glaucoma and AD, and aging [29,30,31,32,74].```
Sample intent: method



Sample text:```In line with our results, several previous studies demonstrated the anti-proliferative effect of PPARs agonists in several cell types [11-15].```
Sample intent: result



Sample text:```germination stimulatory activity by germination bioassays with Striga hermonthica as previously described by Jamil et al. (2010).```
Sample intent: background



Sample text:```Although NO can react directly with O2 - to form peroxynitrite (Lipton et al. 1993), the production of O2 - by wounding was from the leaves incubated with water.```
Sample intent: method



Sample text:```The inter-relationships between K1, K1O and anticoagulants in dogs and humans have been previously investigated [25, 26].```
Sample intent: background



Sample text:```In the subsequent studies, Yoshida et al. (2004b) and Ishii et al. (2004) confirmed the reversibility of 2,6-dihydroxybenzoate decarboxylase of Rhizobium sp. strain MTP-10005 and R.radiobacter WU-0108, respectively.```
Sample intent: result



Sample text:```In our previous study, we found that RAG-mediated nicking and cleavage of oligonucleotide substrates containing cRSSs identified from lymphoid malignancies were either unchanged or slightly reduced in the presence of HMGB1 for most cRSSs tested (including LMO2, TAL1, Hox11, SIL, SCL), except Ttg-1 [24].```
Sample intent: method



Sample text:```due to mitochondrial dysfunction caused by age-related mitochondrial DNA mutations, deletions 151 (10, 21) and damage (25, 59).```
Sample intent: method



Sample text:```Intriguingly, using MPRs-deficient MEF cells, mouse and human CLN5 have been shown to reach lysosomes in an MPRindependent manner [12].```
Sample intent: background



Sample text:```Our results on working memory performance are similar to those of earlier studies (e.g. Archbold et al., 2009; Cosentino et al., 2008; Naegele et al., 2006) in showing impaired working memory in the OSA group.```
Sample intent: result