Different mechanisms explaining why metformin therapy would facilitate ovulation induction by CC in CC-resistant PCOS patients have been proposed, including an intrinsic alteration of follicle steroidogenesis through the insulin-libe growth factor-I (IGF-I) pathway in granulosa cells,(8) direct inhibition of androgen production in ovarian thecal cells,(23) reduction in the adrenal steroidogenesis response to adrenocorticotropic hormone (ACTH),(24) and, more recently, metformin’s central action on the pituitary gland, with LH lowering and prolactin effects in women with PCOS.(25)
Sample text:```Similarly, a synergistic effect of sequence differences at the resistin locus on obesity and risk of type II diabetes has been observed (Ma et al, 2002).```
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Sample text:```In addition, consistent with the result of our preclinical study, recent clinical study showed that alectinib was also highly active against ALK-positive NSCLC patients after treatment with crizotinib [21].```
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Sample text:```1997), fertilization in flowering plants (Digonnet et al. 1997), pollen germination, pollen tube growth (Li et al.```
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Sample text:```LG/J and SM/J mice have been shown to differ in their response to a high-fat diet for traits involved in various metabolic syndrome domains [23,24].```
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Sample text:```Such kinds of response have been observed in female exposed chronically to glucocorticoid.(16) Moreover, testicular steroidogenic activities in the fetus start at earlier part of the last week of gestation in rats.```
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Sample text:```For experiments measuring the effect of Sch-28080 and ouabain on pHi recovery in ICs, only basolateral Cl removal was used to differentiate IC types (15, 17).```
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Sample text:```germination stimulatory activity by germination bioassays with Striga hermonthica as previously described by Jamil et al. (2010).```
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Sample text:```The ¬¨¬µ-opioid receptor agonist morphine also induced inhibitory effects in both assays, in accordance with previous reports describing the opiate-mediated inhibition of the BSL evoked in mice by excitatory amino acids and neurokinins (Aanonsen et al. 1987; Takahasi et al. 1987; Wilcox 1988).```
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Sample text:```This means that accumulation of the CMG helicase with hyperphosphorylated Psf1 is a sensitive marker for the aberrant firing of late-origins in cells treated with hydroxyurea (42), reflecting a specific failure to activate the S-phase checkpoint response at some point downstream of the Mec1 kinase.```
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Sample text:```For experiments measuring the effect of Sch-28080 and ouabain on pHi recovery in ICs, only basolateral Cl removal was used to differentiate IC types (15, 17).```
Sample intent: background



Sample text:```Similarly, a synergistic effect of sequence differences at the resistin locus on obesity and risk of type II diabetes has been observed (Ma et al, 2002).```
Sample intent: method



Sample text:```However, we did not observe any association of maternal free thyroxine with child neurodevelopmental outcomes, agreeing with the Project Viva results (11) but not with those of other studies (8‚Äì10, 43).```
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Sample text:```In line with our results, several previous studies demonstrated the anti-proliferative effect of PPARs agonists in several cell types [11-15].```
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Sample text:```LG/J and SM/J mice have been shown to differ in their response to a high-fat diet for traits involved in various metabolic syndrome domains [23,24].```
Sample intent: method



Sample text:```Basal ATP concentrations in the bulk medium of unstimulated CFs are low, but the concentrations of released nucleotides near the cell surface may be sufficient to activate adjacent P2Y receptors and contribute to basal signaling (48, 49).```
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Sample text:```1997), fertilization in flowering plants (Digonnet et al. 1997), pollen germination, pollen tube growth (Li et al.```
Sample intent: background