Oligomeric Aβ aggregation mediates abnormal removal of AMPA receptors from synaptic membranes, interrupts the delivery of intracellular AMPA receptor subunits to synapses, and thus suppresses hippocampal LTP (Hsieh et al., 2006; Gu et al., 2009; Minano-Molina et al., 2011).
Sample text:```Induction of C1qa in the CNS promotes synapse elimination and synaptic dysfunction during development, neurodegenerative diseases such as glaucoma and AD, and aging [29,30,31,32,74].```
Sample intent: method
Sample text:```They demonstrated by in vitro and ex vivo studies that ATP1A1 mutants showed loss of pump activity and strongly reduced affinity for potassium, causing inappropriate depolarization of the cells (Beuschlein et al. 2013).```
Sample intent: method



Sample text:```Our results show that after 4 h of thiotepa treatment, the level of expression of anti-apoptotic Bcl-2 was not changed; this confirms the results of a previous study [25].```
Sample intent: result



Sample text:```Although the time-constants of the learning window used in this study were much shorter than those reported for hippocampal neurons by Bi and Poo [27] (viz.```
Sample intent: background



Sample text:```Induction of C1qa in the CNS promotes synapse elimination and synaptic dysfunction during development, neurodegenerative diseases such as glaucoma and AD, and aging [29,30,31,32,74].```
Sample intent: method



Sample text:```Deletion of the α-CTD leads to a loss of NusA functions such as enhanced pausing, Qmediated antitermination, and Q-mediated occlusion of the RNA transcript (72, 126).```
Sample intent: method
Sample text:```They demonstrated by in vitro and ex vivo studies that ATP1A1 mutants showed loss of pump activity and strongly reduced affinity for potassium, causing inappropriate depolarization of the cells (Beuschlein et al. 2013).```
Sample intent: method



Sample text:```Intriguingly, using MPRs-deficient MEF cells, mouse and human CLN5 have been shown to reach lysosomes in an MPRindependent manner [12].```
Sample intent: background



Sample text:```Previous studies revealed that acylcarnitines were elevated early after APAP treatment and that their elevation was indicative of mitochondrial damage and dysfunction.(15,19) In the present study these observations were confirmed, as palmitoylcarnitine was elevated by toxic doses of APAP and maintained at normal levels (compared with untreated controls) by Wy-14,643 pretreatment.```
Sample intent: result



Sample text:```Our results show that after 4 h of thiotepa treatment, the level of expression of anti-apoptotic Bcl-2 was not changed; this confirms the results of a previous study [25].```
Sample intent: result



Sample text:```Although the time-constants of the learning window used in this study were much shorter than those reported for hippocampal neurons by Bi and Poo [27] (viz.```
Sample intent: background



Sample text:```hemicholinium-3, a depletor of endogenous acetylcholine (Parikh and Sarter, 2006); (ii) by enhancing cholinergic tone with AF-DX384, a selective M2/M4 autoreceptor antagonist, that blocks the self-inhibitory mechanism by which acetylcholine regulates its own release and (iii) by selectively blocking M1 muscarinic receptors, key modulators of both LTD and LTP (Calabresi et al., 2000; Wang et al., 2006; Bonsi et al., 2008).```
Sample intent: method



Sample text:```The ¬¨¬µ-opioid receptor agonist morphine also induced inhibitory effects in both assays, in accordance with previous reports describing the opiate-mediated inhibition of the BSL evoked in mice by excitatory amino acids and neurokinins (Aanonsen et al. 1987; Takahasi et al. 1987; Wilcox 1988).```
Sample intent: result



Sample text:```Because previous studies indicated that hexapeptides bind the junction core (29, 32), we tested two junctions, one with an AT-rich core and the other with a GC-rich core (Fig.```
Sample intent: result



Sample text:```Our results on working memory performance are similar to those of earlier studies (e.g. Archbold et al., 2009; Cosentino et al., 2008; Naegele et al., 2006) in showing impaired working memory in the OSA group.```
Sample intent: result



Sample text:```Isolation of cardiomyocytes by standard enzymatic techniques and patch-clamp recordings were performed as described previously [42].```
Sample intent: background