Ischaemic damage resulting from microvascular endothelial disease and/or necrosis of vascular smooth muscle cells and/or pericyte injury is the major theory for the pathogenesis of the classical phenotype of Fabry disease [4, 8, 10, 32].
Sample text:```These are in keeping with earlier studies on the steadystate response (2, 5, 8), step-function response, (3, 5, 6, 14) and sinusoidal response ( 14) of the various vascular beds.```
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Sample text:```Endothelial cell cultures and capillary tubeswere generated as previously described (5, 11).```
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Sample text:```They demonstrated by in vitro and ex vivo studies that ATP1A1 mutants showed loss of pump activity and strongly reduced affinity for potassium, causing inappropriate depolarization of the cells (Beuschlein et al. 2013).```
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Sample text:```due to mitochondrial dysfunction caused by age-related mitochondrial DNA mutations, deletions 151 (10, 21) and damage (25, 59).```
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Sample text:```These are in keeping with earlier studies on the steadystate response (2, 5, 8), step-function response, (3, 5, 6, 14) and sinusoidal response ( 14) of the various vascular beds.```
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Sample text:```The admission assessment included determining the risk factors for cerebral infarction,13,14 clinical ischemic stroke category (National Institute of Neurological Disorders and Stroke1), and disease severity using the National Institutes of Health Stroke Scale.15
545
Abbreviations
AF = Atrial fibrillation
LAA = Left atrial appendage
LAA eV = LAA emptying flow velocity
LAD = Left atrial dimension
LAWV = LAA peak wall velocity
ROC = Receiver operating characteristic
SEC = Spontaneous echocardiographic contrast
TEE = Transesophageal echocardiography
TTE = Transthoracic echocardiography
We defined patients who had no histories of AF and no documented AF on continuous electrocardiographic monitoring during hospitalization as the sinus rhythm group, patients who had histories of AF before admission and/or continuously documented AF on continuous electrocardiographic monitoring during hospitalization as having chronic AF, and patients who had AF at admission and recovered to normal sinus rhythm during hospitalization and/or showed sinus rhythm at admission and documented transient AF on continuous electrocardiographic monitoring during hospitalization as having paroxysmal AF.```
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Sample text:```The vast majority of mutations in FUS/TLS-related familial ALS cases were identified in C-terminal NLS, which result in the retention and the inclusion of FUS/TLS in the cytoplasm [2,3,5,8,14], and FUS/TLS as well as TDP-43 is recruited to SGs under stress conditions such as arsenite, heat shock and hypoxia [28,29,30].```
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Sample text:```They demonstrated by in vitro and ex vivo studies that ATP1A1 mutants showed loss of pump activity and strongly reduced affinity for potassium, causing inappropriate depolarization of the cells (Beuschlein et al. 2013).```
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Sample text:```In line with previous results (3, 19, 20, 30), we found that during muscle contraction ERK1/2 phosphorylation was increased and was not affected by CaMKII inhibition.```
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Sample text:```The admission assessment included determining the risk factors for cerebral infarction,13,14 clinical ischemic stroke category (National Institute of Neurological Disorders and Stroke1), and disease severity using the National Institutes of Health Stroke Scale.15
545
Abbreviations
AF = Atrial fibrillation
LAA = Left atrial appendage
LAA eV = LAA emptying flow velocity
LAD = Left atrial dimension
LAWV = LAA peak wall velocity
ROC = Receiver operating characteristic
SEC = Spontaneous echocardiographic contrast
TEE = Transesophageal echocardiography
TTE = Transthoracic echocardiography
We defined patients who had no histories of AF and no documented AF on continuous electrocardiographic monitoring during hospitalization as the sinus rhythm group, patients who had histories of AF before admission and/or continuously documented AF on continuous electrocardiographic monitoring during hospitalization as having chronic AF, and patients who had AF at admission and recovered to normal sinus rhythm during hospitalization and/or showed sinus rhythm at admission and documented transient AF on continuous electrocardiographic monitoring during hospitalization as having paroxysmal AF.```
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Sample text:```ly), which have been originally identified as molecules activated by growth factor-stimulation of fibroblusts, are key kinases in the intracellular signal transduction pathways (1-6).```
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Sample text:```Trials were considered eligible if they satisfied the following inclusion criteria: (1) RCTs comparing RIC versus no conditioning in patients with AMI; (2) patients were treated by primary PCI or thrombolysis; (3) RIC was induced by intermittent limb ischemia–reperfusion; and (4) trials at least reported one of the following outcome measures, including enzymatic myocardial infarction size as assessed by serum peak creatine```
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Sample text:```These are in keeping with earlier studies on the steadystate response (2, 5, 8), step-function response, (3, 5, 6, 14) and sinusoidal response ( 14) of the various vascular beds.```
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Sample text:```Previous studies revealed that acylcarnitines were elevated early after APAP treatment and that their elevation was indicative of mitochondrial damage and dysfunction.(15,19) In the present study these observations were confirmed, as palmitoylcarnitine was elevated by toxic doses of APAP and maintained at normal levels (compared with untreated controls) by Wy-14,643 pretreatment.```
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Sample text:```due to mitochondrial dysfunction caused by age-related mitochondrial DNA mutations, deletions 151 (10, 21) and damage (25, 59).```
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Sample text:```These results are in line with morphological abnormalities in a rabbit model of pneumococcal meningitis [8, 47], in neonatal and adult rat models [7, 51] and in human autopsy cases [20].```
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