The net result is ATP and NAD depletion and cell death by programmed necrosis (25).
Sample text:```due to mitochondrial dysfunction caused by age-related mitochondrial DNA mutations, deletions 151 (10, 21) and damage (25, 59).```
Sample intent: method
Sample text:```Two days after transfection, cells were harvested and D2 activity was measured in lysates using HPLC, as described previously (20).```
Sample intent: background



Sample text:```Consistent with our results, there was no significant association of 25(OH)D and mortality in a 3-year follow-up study of 230 Chinese patients with a median peritoneal dialysis duration of 26 months [7].```
Sample intent: result



Sample text:```Intriguingly, using MPRs-deficient MEF cells, mouse and human CLN5 have been shown to reach lysosomes in an MPRindependent manner [12].```
Sample intent: background



Sample text:```In line with our results, several previous studies demonstrated the anti-proliferative effect of PPARs agonists in several cell types [11-15].```
Sample intent: result



Sample text:```Our results show that after 4 h of thiotepa treatment, the level of expression of anti-apoptotic Bcl-2 was not changed; this confirms the results of a previous study [25].```
Sample intent: result
Sample text:```Our results show that after 4 h of thiotepa treatment, the level of expression of anti-apoptotic Bcl-2 was not changed; this confirms the results of a previous study [25].```
Sample intent: result



Sample text:```Basal ATP concentrations in the bulk medium of unstimulated CFs are low, but the concentrations of released nucleotides near the cell surface may be sufficient to activate adjacent P2Y receptors and contribute to basal signaling (48, 49).```
Sample intent: method



Sample text:```Previous studies revealed that acylcarnitines were elevated early after APAP treatment and that their elevation was indicative of mitochondrial damage and dysfunction.(15,19) In the present study these observations were confirmed, as palmitoylcarnitine was elevated by toxic doses of APAP and maintained at normal levels (compared with untreated controls) by Wy-14,643 pretreatment.```
Sample intent: result



Sample text:```In line with our results, several previous studies demonstrated the anti-proliferative effect of PPARs agonists in several cell types [11-15].```
Sample intent: result



Sample text:```They demonstrated by in vitro and ex vivo studies that ATP1A1 mutants showed loss of pump activity and strongly reduced affinity for potassium, causing inappropriate depolarization of the cells (Beuschlein et al. 2013).```
Sample intent: method



Sample text:```Intriguingly, using MPRs-deficient MEF cells, mouse and human CLN5 have been shown to reach lysosomes in an MPRindependent manner [12].```
Sample intent: background



Sample text:```For experiments measuring the effect of Sch-28080 and ouabain on pHi recovery in ICs, only basolateral Cl removal was used to differentiate IC types (15, 17).```
Sample intent: background



Sample text:```Dead individuals were removed, surface sterilized with 5.2% sodium hypochlorite, rinsed twice with sterile water, and plated on potato dextrose agar to confirm that mortality was due to infection by M. anisopliae (Rosengaus et al. 1998).```
Sample intent: background



Sample text:```due to mitochondrial dysfunction caused by age-related mitochondrial DNA mutations, deletions 151 (10, 21) and damage (25, 59).```
Sample intent: method



Sample text:```The method of induction of CHF by rapid pacing has been described in detail previously (30, 31).```
Sample intent: background