The effect of the combination of ERT and PCT in FD fibroblasts was much higher than that observed in our previous study on the synergy of ERT and chaperones in PD fibroblasts (Porto et al. 2009).
Sample text:```In this study, the proposed method is based on atrial activity extraction using an echo state network (ESN) re­ cently introduced as a unified solution to the problem of QRST cancellation in the presence of substantial variation in beat morphology and/or occasional ectopic beats [7].```
Sample intent: background
Sample text:```Basal ATP concentrations in the bulk medium of unstimulated CFs are low, but the concentrations of released nucleotides near the cell surface may be sufficient to activate adjacent P2Y receptors and contribute to basal signaling (48, 49).```
Sample intent: method



Sample text:```ly), which have been originally identified as molecules activated by growth factor-stimulation of fibroblusts, are key kinases in the intracellular signal transduction pathways (1-6).```
Sample intent: method



Sample text:```Our results confi rm previous studies that reached the same conclusion (Boushey et al 1994; Vermeulen et al 2000; Till et al 2005; Marcucci et al 2005).```
Sample intent: result



Sample text:```In this study, the proposed method is based on atrial activity extraction using an echo state network (ESN) re­ cently introduced as a unified solution to the problem of QRST cancellation in the presence of substantial variation in beat morphology and/or occasional ectopic beats [7].```
Sample intent: background



Sample text:```Isolation of cardiomyocytes by standard enzymatic techniques and patch-clamp recordings were performed as described previously [42].```
Sample intent: background
Sample text:```Our results confi rm previous studies that reached the same conclusion (Boushey et al 1994; Vermeulen et al 2000; Till et al 2005; Marcucci et al 2005).```
Sample intent: result



Sample text:```In this study, the proposed method is based on atrial activity extraction using an echo state network (ESN) re­ cently introduced as a unified solution to the problem of QRST cancellation in the presence of substantial variation in beat morphology and/or occasional ectopic beats [7].```
Sample intent: background



Sample text:```The method of induction of CHF by rapid pacing has been described in detail previously (30, 31).```
Sample intent: background



Sample text:```Intriguingly, using MPRs-deficient MEF cells, mouse and human CLN5 have been shown to reach lysosomes in an MPRindependent manner [12].```
Sample intent: background



Sample text:```Consistent with the notion that Derlin-1 acts in the retrotranslocation [21,22,26,48–51], misfolded proteins accumulate in the ER in derlin-1 mutants, indicative of disrupted ERAD.```
Sample intent: method



Sample text:```Isolation of cardiomyocytes by standard enzymatic techniques and patch-clamp recordings were performed as described previously [42].```
Sample intent: background



Sample text:```In line with previous results (3, 19, 20, 30), we found that during muscle contraction ERK1/2 phosphorylation was increased and was not affected by CaMKII inhibition.```
Sample intent: result



Sample text:```Previous studies revealed that acylcarnitines were elevated early after APAP treatment and that their elevation was indicative of mitochondrial damage and dysfunction.(15,19) In the present study these observations were confirmed, as palmitoylcarnitine was elevated by toxic doses of APAP and maintained at normal levels (compared with untreated controls) by Wy-14,643 pretreatment.```
Sample intent: result



Sample text:```Our results show that after 4 h of thiotepa treatment, the level of expression of anti-apoptotic Bcl-2 was not changed; this confirms the results of a previous study [25].```
Sample intent: result



Sample text:```Our earlier work has stressed the importance of electric field frequency and phase with respect to intracellular chemical oscillators (Kindzelskii and Petty, 2000).```
Sample intent: method