Interestingly, Nutlin-3 has recently been shown to inhibit E2F-1 binding to HDM2, leading to activation of E2F-1 and potentiation of chemotherapy-induced apoptosis in p53mutant but not wt cells (Ambrosini et al., 2007).
Sample text:```In line with our results, several previous studies demonstrated the anti-proliferative effect of PPARs agonists in several cell types [11-15].```
Sample intent: result
Sample text:```The ¬¨¬µ-opioid receptor agonist morphine also induced inhibitory effects in both assays, in accordance with previous reports describing the opiate-mediated inhibition of the BSL evoked in mice by excitatory amino acids and neurokinins (Aanonsen et al. 1987; Takahasi et al. 1987; Wilcox 1988).```
Sample intent: result



Sample text:```In line with our results, several previous studies demonstrated the anti-proliferative effect of PPARs agonists in several cell types [11-15].```
Sample intent: result



Sample text:```Intriguingly, using MPRs-deficient MEF cells, mouse and human CLN5 have been shown to reach lysosomes in an MPRindependent manner [12].```
Sample intent: background



Sample text:```We screened for potential TF binding sites using STAMP [59], with the motifs’ position weight matrices (PWMs) retrieved from the TRANSFAC database [60].```
Sample intent: background



Sample text:```In addition, consistent with the result of our preclinical study, recent clinical study showed that alectinib was also highly active against ALK-positive NSCLC patients after treatment with crizotinib [21].```
Sample intent: result
Sample text:```Overexpression of miR-218 inhibits cancer cell proliferation, migration and invasion [24, 26, 27], and promotes colon cancer cell apoptosis [28].```
Sample intent: method



Sample text:```In addition, consistent with the result of our preclinical study, recent clinical study showed that alectinib was also highly active against ALK-positive NSCLC patients after treatment with crizotinib [21].```
Sample intent: result



Sample text:```In our previous study, we found that RAG-mediated nicking and cleavage of oligonucleotide substrates containing cRSSs identified from lymphoid malignancies were either unchanged or slightly reduced in the presence of HMGB1 for most cRSSs tested (including LMO2, TAL1, Hox11, SIL, SCL), except Ttg-1 [24].```
Sample intent: method



Sample text:```Previous studies described that ectopic miR-99a expression slowed keratinocyte growth and liver cancer cell growth by blocking the cell cycle at the G1/S transition [10,29].```
Sample intent: method



Sample text:```Intriguingly, using MPRs-deficient MEF cells, mouse and human CLN5 have been shown to reach lysosomes in an MPRindependent manner [12].```
Sample intent: background



Sample text:```The ¬¨¬µ-opioid receptor agonist morphine also induced inhibitory effects in both assays, in accordance with previous reports describing the opiate-mediated inhibition of the BSL evoked in mice by excitatory amino acids and neurokinins (Aanonsen et al. 1987; Takahasi et al. 1987; Wilcox 1988).```
Sample intent: result



Sample text:```This study supports the theory of a tumor origin from multipotential progenitor cells.(14) Reports of the Ki67 labeling index have demonstrated great variety.```
Sample intent: result



Sample text:```Lee et al. (2001) Human lung squamous cell carcinoma (CH27), human lung nonsmall cell carcinoma (H460) CH27 and H460 cells were treated with aloeemodin or emodin.```
Sample intent: method



Sample text:```Two days after transfection, cells were harvested and D2 activity was measured in lysates using HPLC, as described previously (20).```
Sample intent: background



Sample text:```germination stimulatory activity by germination bioassays with Striga hermonthica as previously described by Jamil et al. (2010).```
Sample intent: background