HGPIN was another strong predictor, in contrast to recent reports that cancer prevalence on repeat biopsy was only marginally greater among men with HGPIN versus men with completely benign findings.(15,16) The prognostic significance of isolated HGPIN may have declined as a result of more intensive biopsy sampling schemes and the tendency for repeated PSA testing to cull out larger tumors in screened populations.
Sample text:```This study supports the theory of a tumor origin from multipotential progenitor cells.(14) Reports of the Ki67 labeling index have demonstrated great variety.```
Sample intent: result
Sample text:```Laboratory parameters considered in this study were those already found significantly different between early PMF and WHO-ET: Hb (g/dL), WBC (3109/L), PLT (3109/L), and LDH (mU/mL).```
Sample intent: background



Sample text:```Our results confi rm previous studies that reached the same conclusion (Boushey et al 1994; Vermeulen et al 2000; Till et al 2005; Marcucci et al 2005).```
Sample intent: result



Sample text:```To further characterize isolates, random amplification of polymorphic DNA polymerase chain reaction (RAPD-PCR) was performed using an adaptation of methods described elsewhere.(10)```
Sample intent: background



Sample text:```Participants were undergraduates who had been followed during their college career as part of a longitudinal cohort study (see Bonanno et al., 2004; Papa & Bonanno, 2008).```
Sample intent: background



Sample text:```For monitoring purposes, the investigator also determined the polyp score (PS) based on the size of polyps at the first and last visits [14].```
Sample intent: background
Sample text:```Results from a RCT assessing in-person post-test genomic counseling on 199 OSU-CMPC participants were published previously [18].```
Sample intent: method



Sample text:```However, the clinical value of CA125 as a marker of ovarian cancer is low, due to its expression in non-malignant or non-ovarian malignant conditions (Tuxen et al, 1995; Meyer and Rustin, 2000).```
Sample intent: method



Sample text:```Our results confi rm previous studies that reached the same conclusion (Boushey et al 1994; Vermeulen et al 2000; Till et al 2005; Marcucci et al 2005).```
Sample intent: result



Sample text:```Laboratory parameters considered in this study were those already found significantly different between early PMF and WHO-ET: Hb (g/dL), WBC (3109/L), PLT (3109/L), and LDH (mU/mL).```
Sample intent: background



Sample text:```We used longitudinal sequence samples for 15 patients from two independent studies [13,22].```
Sample intent: background



Sample text:```In our previous study, we found that RAG-mediated nicking and cleavage of oligonucleotide substrates containing cRSSs identified from lymphoid malignancies were either unchanged or slightly reduced in the presence of HMGB1 for most cRSSs tested (including LMO2, TAL1, Hox11, SIL, SCL), except Ttg-1 [24].```
Sample intent: method



Sample text:```Participants were undergraduates who had been followed during their college career as part of a longitudinal cohort study (see Bonanno et al., 2004; Papa & Bonanno, 2008).```
Sample intent: background



Sample text:```This study supports the theory of a tumor origin from multipotential progenitor cells.(14) Reports of the Ki67 labeling index have demonstrated great variety.```
Sample intent: result



Sample text:```To further characterize isolates, random amplification of polymorphic DNA polymerase chain reaction (RAPD-PCR) was performed using an adaptation of methods described elsewhere.(10)```
Sample intent: background



Sample text:```This means that accumulation of the CMG helicase with hyperphosphorylated Psf1 is a sensitive marker for the aberrant firing of late-origins in cells treated with hydroxyurea (42), reflecting a specific failure to activate the S-phase checkpoint response at some point downstream of the Mec1 kinase.```
Sample intent: method