Recent studies suggest that apoE4 contributes to vascular and neuronal dysfunction via both Aβ-dependent and Aβindependent pathways (Deane et al., 2008; Bell et al., 2012; Hudry et al., 2013; Huang and Mahley, 2014; Casey et al., 2015; Halliday et al., 2015).
Sample text:```Although the time-constants of the learning window used in this study were much shorter than those reported for hippocampal neurons by Bi and Poo [27] (viz.```
Sample intent: background
Sample text:```Although the time-constants of the learning window used in this study were much shorter than those reported for hippocampal neurons by Bi and Poo [27] (viz.```
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Sample text:```Our results show that after 4 h of thiotepa treatment, the level of expression of anti-apoptotic Bcl-2 was not changed; this confirms the results of a previous study [25].```
Sample intent: result



Sample text:```Importantly, brain atrophy measures based on T1w images are shown to correlate with the amount of tau deposition and neuropsychological deficits, thus validating its use as a biomarker of Alzheimer’s disease (AD) (Frisoni et al., 2010).```
Sample intent: method



Sample text:```Intriguingly, using MPRs-deficient MEF cells, mouse and human CLN5 have been shown to reach lysosomes in an MPRindependent manner [12].```
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Sample text:```They demonstrated by in vitro and ex vivo studies that ATP1A1 mutants showed loss of pump activity and strongly reduced affinity for potassium, causing inappropriate depolarization of the cells (Beuschlein et al. 2013).```
Sample intent: method
Sample text:```Intriguingly, using MPRs-deficient MEF cells, mouse and human CLN5 have been shown to reach lysosomes in an MPRindependent manner [12].```
Sample intent: background



Sample text:```These results are in line with morphological abnormalities in a rabbit model of pneumococcal meningitis [8, 47], in neonatal and adult rat models [7, 51] and in human autopsy cases [20].```
Sample intent: result



Sample text:```They demonstrated by in vitro and ex vivo studies that ATP1A1 mutants showed loss of pump activity and strongly reduced affinity for potassium, causing inappropriate depolarization of the cells (Beuschlein et al. 2013).```
Sample intent: method



Sample text:```In the last 5 years, it has been published as the most comprehensive study on the distribution of PLCb1 in the mouse brain, showing that it is highly expressed in the somatodendritic compartment of principal neurons of the telencephalon (Fukaya et al., 2008).```
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Sample text:```due to mitochondrial dysfunction caused by age-related mitochondrial DNA mutations, deletions 151 (10, 21) and damage (25, 59).```
Sample intent: method



Sample text:```Importantly, brain atrophy measures based on T1w images are shown to correlate with the amount of tau deposition and neuropsychological deficits, thus validating its use as a biomarker of Alzheimer’s disease (AD) (Frisoni et al., 2010).```
Sample intent: method



Sample text:```Induction of C1qa in the CNS promotes synapse elimination and synaptic dysfunction during development, neurodegenerative diseases such as glaucoma and AD, and aging [29,30,31,32,74].```
Sample intent: method



Sample text:```Our results confi rm previous studies that reached the same conclusion (Boushey et al 1994; Vermeulen et al 2000; Till et al 2005; Marcucci et al 2005).```
Sample intent: result



Sample text:```Participants were undergraduates who had been followed during their college career as part of a longitudinal cohort study (see Bonanno et al., 2004; Papa & Bonanno, 2008).```
Sample intent: background



Sample text:```Our results show that after 4 h of thiotepa treatment, the level of expression of anti-apoptotic Bcl-2 was not changed; this confirms the results of a previous study [25].```
Sample intent: result