On the other hand, the antitumor effects of TNF- are mainly exerted on the tumor endothelium (25, 26), with increased permeability (17, 27, 28), up-regulation of tissue factor (29, 30), fibrin deposition, and thrombosis in the tumor vasculature, accompanied by a massive destruction of the endothelial cells (4, 5) that can be responsible for the antitumor response (26, 31–34).
Sample text:```In line with our results, several previous studies demonstrated the anti-proliferative effect of PPARs agonists in several cell types [11-15].```
Sample intent: result
Sample text:```Overexpression of miR-218 inhibits cancer cell proliferation, migration and invasion [24, 26, 27], and promotes colon cancer cell apoptosis [28].```
Sample intent: method



Sample text:```Intriguingly, using MPRs-deficient MEF cells, mouse and human CLN5 have been shown to reach lysosomes in an MPRindependent manner [12].```
Sample intent: background



Sample text:```Endothelial cell cultures and capillary tubeswere generated as previously described (5, 11).```
Sample intent: background



Sample text:```This study supports the theory of a tumor origin from multipotential progenitor cells.(14) Reports of the Ki67 labeling index have demonstrated great variety.```
Sample intent: result



Sample text:```In line with our results, several previous studies demonstrated the anti-proliferative effect of PPARs agonists in several cell types [11-15].```
Sample intent: result
Sample text:```In line with our results, several previous studies demonstrated the anti-proliferative effect of PPARs agonists in several cell types [11-15].```
Sample intent: result



Sample text:```Endothelial cell cultures and capillary tubeswere generated as previously described (5, 11).```
Sample intent: background



Sample text:```Overexpression of miR-218 inhibits cancer cell proliferation, migration and invasion [24, 26, 27], and promotes colon cancer cell apoptosis [28].```
Sample intent: method



Sample text:```Previous studies revealed that acylcarnitines were elevated early after APAP treatment and that their elevation was indicative of mitochondrial damage and dysfunction.(15,19) In the present study these observations were confirmed, as palmitoylcarnitine was elevated by toxic doses of APAP and maintained at normal levels (compared with untreated controls) by Wy-14,643 pretreatment.```
Sample intent: result



Sample text:```germination stimulatory activity by germination bioassays with Striga hermonthica as previously described by Jamil et al. (2010).```
Sample intent: background



Sample text:```Interestingly, MHC I and ERAP1 were coordinately expressed in normal and, to a lesser extent, neoplastic cells and tumor lesions (13, 14).```
Sample intent: method



Sample text:```The ¬¨¬µ-opioid receptor agonist morphine also induced inhibitory effects in both assays, in accordance with previous reports describing the opiate-mediated inhibition of the BSL evoked in mice by excitatory amino acids and neurokinins (Aanonsen et al. 1987; Takahasi et al. 1987; Wilcox 1988).```
Sample intent: result



Sample text:```Aside from the effects on Th1 cells, IL-27 has recently reported that played a regulatory role in limiting excessive inflammation during infection with Toxoplasma gondii by modulating the development of Th17 cells (20, 21).```
Sample intent: method



Sample text:```Our results show that after 4 h of thiotepa treatment, the level of expression of anti-apoptotic Bcl-2 was not changed; this confirms the results of a previous study [25].```
Sample intent: result



Sample text:```Laboratory parameters considered in this study were those already found significantly different between early PMF and WHO-ET: Hb (g/dL), WBC (3109/L), PLT (3109/L), and LDH (mU/mL).```
Sample intent: background