PX-FERM proteins can then interact with NPxY/NxxY motif containing cargo, and also PDZ binding motif (PDZbm) cargo in the case of SNX27, at the early endosomal membrane (Balana et al., 2011; Bottcher et al., 2012; Cai et al., 2011; Ghai et al., 2013; Ghai et al., 2011; Hayashi et al., 2012; Joubert et al., 2004; Knauth et al., 2005; Lauffer et al., 2010; Lunn et al., 2007; Steinberg et al., 2013; Temkin et al., 2011; Valdes et al., 2011; Wang et al., 2013).