…of transgenes remain dependent on fibroblast growth factor (FGF) or transforming growth factor b (TGF-b) (Chan et al., 2013; Gafni et al., 2013; Valamehr et al., 2014; Ware et al., 2014; Duggal et al., 2015; Qin et al., 2016), which is a major property of the primed state (Vallier et al., 2005).