…with a number of regulatory factors, including the putative Rab7 GTPaseactivating protein TBC1D5 (Seaman et al., 2009; Harbour et al., 2010), and retromer tubule formation is reported to be maximal at the time of Rab5-to-Rab7 conversion (Cullen and Korswagen, 2012; van Weering et al., 2012).