Previously reported naive-state hPSCs can be propagated in an LIF-dependent state in a manner akin to that of mESCs using a cocktail of small molecules (Gafni et al., 2013; Chan et al., 2013; Theunissen et al., 2014; Valamehr et al., 2014;Ware et al., 2014; Duggal et al., 2015).