FGFR4 Blockade Attenuates LVH in the 5/6 Nephrectomy Rat Model of CKD We tested the therapeutic potential of interfering with cardiac FGF23-FGFR4 signaling in the 5/6 nephrectomy rat model of CKD that develops increased FGF23 levels, severe hypertension, and LVH within 14 days after nephrectomy (Faul et al., 2011).