Recent studies have shown that many pathogens, including Listeria monocytogenes and Yersinia pseudotuberculosis, utilize the ‘zippering’ pathway of invasion, highjacking the clathrin-, caveolin- and ubiquitin-mediated endocytosis of host receptors to gain access to the nutrient-rich intracellular environment of mammalian host cells (Veiga and Cossart, 2005; Bonazzi and Cossart, 2006; Hamon et al., 2006).