There was a good correlation between the in vitro and in vivo relative abundance of oxidised metabolites (4 -OH-aceclofenac + 4 -OH-diclofenac; Spearman’s  = 0.855), and the hydrolysis of aceclofenac (diclofenac + 4 -OH-aceclofenac + 4 -OH-diclofenac;  = 0.691), while the conjugation of the drug in vitro was somewhat lower than in vivo.
Il è una bona correlatione che l’abondanza relativa in vitro e in vivo di metaboliti oxidi (4 -OH-aceclofenac + 4 -OH-diclofenac; Spearman  = 0,855), e l’hydrolyse del aceclofenac (diclofenac + 4 -OH-aceclofenac + 4 -OH-diclofenac;  = 0.691), tando la conjugazione del medicamento in vitro era un peu mai basa che in vivo.