question
stringlengths 16
191
| answer
stringlengths 6
29k
| input_ids
sequence | attention_mask
sequence | labels
sequence |
|---|---|---|---|---|
What is (are) Medullary Sponge Kidney ? | Medullary sponge kidney, also known as Cacchi-Ricci disease, is a birth defect where changes occur in the tubules, or tiny tubes, inside a fetus kidneys.
In a normal kidney, urine flows through these tubules as the kidney is being formed during a fetus growth. In medullary sponge kidney, tiny, fluid-filled sacs called cysts form in the tubules within the medullathe inner part of the kidneycreating a spongelike appearance. The cysts keep urine from flowing freely through the tubules.
Symptoms of medullary sponge kidney do not usually appear until the teenage years or the 20s. Medullary sponge kidney can affect one or both kidneys. | [
1276,
310,
313,
609,
10,
3050,
46909,
2101,
25709,
26184,
2191,
3736,
10818,
46909,
39088,
12333,
13,
671,
1929,
347,
330,
317,
4635,
14,
45668,
5297,
2728,
13,
310,
247,
4201,
7071,
835,
2544,
2826,
275,
253,
6985,
2651,
13,
390,
10058,
17080,
13,
3304,
247,
36866,
33193,
15,
187,
50262,
187,
688,
247,
2622,
12333,
13,
16327,
14221,
949,
841,
6985,
2651,
347,
253,
12333,
310,
1146,
4447,
1309,
247,
36866,
3116,
15,
496,
1129,
46909,
39088,
12333,
13,
10058,
13,
6514,
14,
14653,
7044,
84,
1925,
41578,
830,
275,
253,
6985,
2651,
1561,
253,
1129,
962,
4349,
6703,
629,
273,
253,
12333,
20132,
272,
247,
48230,
44549,
7286,
15,
380,
41578,
1978,
16327,
432,
19246,
15744,
949,
253,
6985,
2651,
15,
187,
50262,
187,
23875,
431,
3056,
273,
1129,
46909,
39088,
12333,
513,
417,
3798,
3176,
1919,
253,
29386,
1107,
390,
253,
1384,
84,
15,
3050,
46909,
39088,
12333,
476,
2818,
581,
390,
1097,
33193,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
310,
313,
609,
10,
3050,
46909,
2101,
25709,
26184,
2191,
3736,
10818,
46909,
39088,
12333,
13,
671,
1929,
347,
330,
317,
4635,
14,
45668,
5297,
2728,
13,
310,
247,
4201,
7071,
835,
2544,
2826,
275,
253,
6985,
2651,
13,
390,
10058,
17080,
13,
3304,
247,
36866,
33193,
15,
187,
50262,
187,
688,
247,
2622,
12333,
13,
16327,
14221,
949,
841,
6985,
2651,
347,
253,
12333,
310,
1146,
4447,
1309,
247,
36866,
3116,
15,
496,
1129,
46909,
39088,
12333,
13,
10058,
13,
6514,
14,
14653,
7044,
84,
1925,
41578,
830,
275,
253,
6985,
2651,
1561,
253,
1129,
962,
4349,
6703,
629,
273,
253,
12333,
20132,
272,
247,
48230,
44549,
7286,
15,
380,
41578,
1978,
16327,
432,
19246,
15744,
949,
253,
6985,
2651,
15,
187,
50262,
187,
23875,
431,
3056,
273,
1129,
46909,
39088,
12333,
513,
417,
3798,
3176,
1919,
253,
29386,
1107,
390,
253,
1384,
84,
15,
3050,
46909,
39088,
12333,
476,
2818,
581,
390,
1097,
33193,
15
] |
What are the treatments for Weissenbacher-Zweymller syndrome ? | These resources address the diagnosis or management of Weissenbacher-Zweymller syndrome: - Genetic Testing Registry: Weissenbacher-Zweymuller syndrome These resources from MedlinePlus offer information about the diagnosis and management of various health conditions: - Diagnostic Tests - Drug Therapy - Surgery and Rehabilitation - Genetic Counseling - Palliative Care | [
1276,
403,
253,
9694,
323,
34167,
257,
67,
12844,
14,
59,
664,
1105,
22999,
9237,
3736,
6872,
5300,
2953,
253,
6120,
390,
4323,
273,
34167,
257,
67,
12844,
14,
59,
664,
1105,
22999,
9237,
27,
50276,
14,
37003,
30750,
38227,
27,
34167,
257,
67,
12844,
14,
59,
664,
1105,
962,
254,
9237,
50275,
6872,
5300,
432,
3050,
1282,
25263,
3959,
1491,
670,
253,
6120,
285,
4323,
273,
2710,
1786,
2515,
27,
50276,
14,
44194,
32503,
50276,
14,
16686,
34294,
50276,
14,
34621,
285,
49251,
50276,
14,
37003,
19330,
272,
50275,
14,
42745,
18168,
9776
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
403,
253,
9694,
323,
34167,
257,
67,
12844,
14,
59,
664,
1105,
22999,
9237,
3736,
6872,
5300,
2953,
253,
6120,
390,
4323,
273,
34167,
257,
67,
12844,
14,
59,
664,
1105,
22999,
9237,
27,
50276,
14,
37003,
30750,
38227,
27,
34167,
257,
67,
12844,
14,
59,
664,
1105,
962,
254,
9237,
50275,
6872,
5300,
432,
3050,
1282,
25263,
3959,
1491,
670,
253,
6120,
285,
4323,
273,
2710,
1786,
2515,
27,
50276,
14,
44194,
32503,
50276,
14,
16686,
34294,
50276,
14,
34621,
285,
49251,
50276,
14,
37003,
19330,
272,
50275,
14,
42745,
18168,
9776
] |
What is (are) Autoimmune hemolytic anemia ? | Autoimmune hemolytic anemia (AIHA) occurs when your immune system makes antibodies that attack your red blood cells. This causes a drop in the number of red blood cells, leading to hemolytic anemia. Symptoms may include unusual weakness and fatigue with tachycardia and breathing difficulties, jaundice, dark urine and/or splenomegaly. AIHA can be primary (idiopathic) or result from an underlying disease or medication. The condition may develop gradually or occur suddenly. There are two main types of autoimmune hemolytic anemia: warm antibody hemolytic anemia and cold antibody hemolytic anemia. Treatment may include corticosteroids such as prednisone, splenectomy, immunosuppressive drugs and/or blood transfusions. | [
1276,
310,
313,
609,
10,
17252,
20916,
7492,
21200,
31442,
3736,
22156,
20916,
7492,
21200,
31442,
313,
18128,
10114,
10,
6634,
672,
634,
7026,
985,
2789,
8740,
326,
2983,
634,
2502,
2614,
1341,
15,
831,
5997,
247,
5926,
275,
253,
1180,
273,
2502,
2614,
1341,
13,
4283,
281,
7492,
21200,
31442,
15,
40561,
3056,
778,
2486,
11555,
14855,
285,
18693,
342,
38922,
41434,
285,
14578,
12748,
13,
8729,
1504,
547,
13,
3644,
16327,
285,
16,
263,
48507,
485,
72,
5242,
15,
14980,
10114,
476,
320,
3625,
313,
13535,
27406,
10,
390,
906,
432,
271,
6944,
2728,
390,
12358,
15,
380,
1617,
778,
1287,
13237,
390,
2826,
8423,
15,
1707,
403,
767,
2022,
3510,
273,
25787,
7492,
21200,
31442,
27,
5890,
8092,
7492,
21200,
31442,
285,
5412,
8092,
7492,
21200,
31442,
15,
17012,
778,
2486,
49796,
824,
347,
2063,
24836,
531,
13,
48507,
28857,
13,
45169,
5835,
285,
16,
263,
2614,
47415,
16723,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
310,
313,
609,
10,
17252,
20916,
7492,
21200,
31442,
3736,
22156,
20916,
7492,
21200,
31442,
313,
18128,
10114,
10,
6634,
672,
634,
7026,
985,
2789,
8740,
326,
2983,
634,
2502,
2614,
1341,
15,
831,
5997,
247,
5926,
275,
253,
1180,
273,
2502,
2614,
1341,
13,
4283,
281,
7492,
21200,
31442,
15,
40561,
3056,
778,
2486,
11555,
14855,
285,
18693,
342,
38922,
41434,
285,
14578,
12748,
13,
8729,
1504,
547,
13,
3644,
16327,
285,
16,
263,
48507,
485,
72,
5242,
15,
14980,
10114,
476,
320,
3625,
313,
13535,
27406,
10,
390,
906,
432,
271,
6944,
2728,
390,
12358,
15,
380,
1617,
778,
1287,
13237,
390,
2826,
8423,
15,
1707,
403,
767,
2022,
3510,
273,
25787,
7492,
21200,
31442,
27,
5890,
8092,
7492,
21200,
31442,
285,
5412,
8092,
7492,
21200,
31442,
15,
17012,
778,
2486,
49796,
824,
347,
2063,
24836,
531,
13,
48507,
28857,
13,
45169,
5835,
285,
16,
263,
2614,
47415,
16723,
15
] |
What is (are) Ehlers-Danlos syndrome, dermatosparaxis type ? | Ehlers-Danlos syndrome (EDS), dermatosparaxis type is an inherited connective tissue disorder that is caused by defects in a protein called collagen. Common symptoms include soft, doughy skin that is extremely fragile; saggy, redundant skin, especially on the face; hernias; and mild to severe joint hypermobility. EDS, dermatosparaxis type is caused by changes (mutations) in the ADAMTS2 gene and is inherited in an autosomal recessive manner. Treatment and management is focused on preventing serious complications and relieving associated signs and symptoms. | [
1276,
310,
313,
609,
10,
37646,
10787,
14,
15961,
26185,
9237,
13,
23191,
29392,
1148,
10565,
1511,
3736,
47733,
10787,
14,
15961,
26185,
9237,
313,
1703,
52,
582,
23191,
29392,
1148,
10565,
1511,
310,
271,
20265,
41292,
4408,
8984,
326,
310,
4269,
407,
12834,
275,
247,
2601,
1925,
15546,
15,
10200,
5917,
2486,
2602,
13,
17652,
90,
4808,
326,
310,
6685,
28304,
28,
18561,
4233,
13,
28116,
4808,
13,
3340,
327,
253,
2454,
28,
617,
79,
6358,
28,
285,
11134,
281,
5460,
6036,
4373,
42096,
874,
15,
444,
5942,
13,
23191,
29392,
1148,
10565,
1511,
310,
4269,
407,
2544,
313,
10082,
569,
10,
275,
253,
5446,
2300,
6901,
19,
3320,
285,
310,
20265,
275,
271,
48981,
24096,
422,
5133,
15,
17012,
285,
4323,
310,
7106,
327,
13538,
4092,
10552,
285,
18604,
1382,
2330,
7871,
285,
5917,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
310,
313,
609,
10,
37646,
10787,
14,
15961,
26185,
9237,
13,
23191,
29392,
1148,
10565,
1511,
3736,
47733,
10787,
14,
15961,
26185,
9237,
313,
1703,
52,
582,
23191,
29392,
1148,
10565,
1511,
310,
271,
20265,
41292,
4408,
8984,
326,
310,
4269,
407,
12834,
275,
247,
2601,
1925,
15546,
15,
10200,
5917,
2486,
2602,
13,
17652,
90,
4808,
326,
310,
6685,
28304,
28,
18561,
4233,
13,
28116,
4808,
13,
3340,
327,
253,
2454,
28,
617,
79,
6358,
28,
285,
11134,
281,
5460,
6036,
4373,
42096,
874,
15,
444,
5942,
13,
23191,
29392,
1148,
10565,
1511,
310,
4269,
407,
2544,
313,
10082,
569,
10,
275,
253,
5446,
2300,
6901,
19,
3320,
285,
310,
20265,
275,
271,
48981,
24096,
422,
5133,
15,
17012,
285,
4323,
310,
7106,
327,
13538,
4092,
10552,
285,
18604,
1382,
2330,
7871,
285,
5917,
15
] |
What are the treatments for lymphedema-distichiasis syndrome ? | These resources address the diagnosis or management of lymphedema-distichiasis syndrome: - Gene Review: Gene Review: Lymphedema-Distichiasis Syndrome - Genetic Testing Registry: Distichiasis-lymphedema syndrome - MedlinePlus Encyclopedia: Lymph System These resources from MedlinePlus offer information about the diagnosis and management of various health conditions: - Diagnostic Tests - Drug Therapy - Surgery and Rehabilitation - Genetic Counseling - Palliative Care | [
1276,
403,
253,
9694,
323,
298,
43768,
742,
8895,
14,
8155,
22208,
4914,
9237,
3736,
6872,
5300,
2953,
253,
6120,
390,
4323,
273,
298,
43768,
742,
8895,
14,
8155,
22208,
4914,
9237,
27,
50276,
14,
15763,
8439,
27,
15763,
8439,
27,
418,
43768,
742,
8895,
14,
14178,
22208,
4914,
39365,
50276,
14,
37003,
30750,
38227,
27,
3656,
22208,
4914,
14,
9291,
742,
8895,
9237,
50276,
14,
3050,
1282,
25263,
43338,
27,
49684,
4155,
50275,
6872,
5300,
432,
3050,
1282,
25263,
3959,
1491,
670,
253,
6120,
285,
4323,
273,
2710,
1786,
2515,
27,
50276,
14,
44194,
32503,
50276,
14,
16686,
34294,
50276,
14,
34621,
285,
49251,
50276,
14,
37003,
19330,
272,
50275,
14,
42745,
18168,
9776
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
403,
253,
9694,
323,
298,
43768,
742,
8895,
14,
8155,
22208,
4914,
9237,
3736,
6872,
5300,
2953,
253,
6120,
390,
4323,
273,
298,
43768,
742,
8895,
14,
8155,
22208,
4914,
9237,
27,
50276,
14,
15763,
8439,
27,
15763,
8439,
27,
418,
43768,
742,
8895,
14,
14178,
22208,
4914,
39365,
50276,
14,
37003,
30750,
38227,
27,
3656,
22208,
4914,
14,
9291,
742,
8895,
9237,
50276,
14,
3050,
1282,
25263,
43338,
27,
49684,
4155,
50275,
6872,
5300,
432,
3050,
1282,
25263,
3959,
1491,
670,
253,
6120,
285,
4323,
273,
2710,
1786,
2515,
27,
50276,
14,
44194,
32503,
50276,
14,
16686,
34294,
50276,
14,
34621,
285,
49251,
50276,
14,
37003,
19330,
272,
50275,
14,
42745,
18168,
9776
] |
How many people are affected by hypercholesterolemia ? | More than 34 million American adults have elevated blood cholesterol levels (higher than 240 mg/dL). Inherited forms of hypercholesterolemia, which cause even higher levels of cholesterol, occur less frequently. The most common inherited form of high cholesterol is called familial hypercholesterolemia. This condition affects about 1 in 500 people in most countries. Familial hypercholesterolemia occurs more frequently in certain populations, including Afrikaners in South Africa, French Canadians, Lebanese, and Finns. | [
2347,
1142,
952,
403,
5876,
407,
4373,
348,
11201,
1306,
15604,
3736,
7673,
685,
5910,
3041,
2448,
7747,
452,
10702,
2614,
13559,
2308,
313,
41832,
685,
16918,
5770,
16,
21087,
481,
496,
379,
959,
4948,
273,
4373,
348,
11201,
1306,
15604,
13,
534,
2847,
1014,
2169,
2308,
273,
13559,
13,
2826,
1679,
7208,
15,
380,
954,
1846,
20265,
830,
273,
1029,
13559,
310,
1925,
36490,
4373,
348,
11201,
1306,
15604,
15,
831,
1617,
11852,
670,
337,
275,
6783,
952,
275,
954,
4343,
15,
401,
34206,
451,
4373,
348,
11201,
1306,
15604,
6634,
625,
7208,
275,
2176,
7625,
13,
1690,
3723,
16409,
266,
398,
275,
3684,
7531,
13,
5112,
32846,
13,
46900,
13,
285,
7198,
2224,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
2347,
1142,
952,
403,
5876,
407,
4373,
348,
11201,
1306,
15604,
3736,
7673,
685,
5910,
3041,
2448,
7747,
452,
10702,
2614,
13559,
2308,
313,
41832,
685,
16918,
5770,
16,
21087,
481,
496,
379,
959,
4948,
273,
4373,
348,
11201,
1306,
15604,
13,
534,
2847,
1014,
2169,
2308,
273,
13559,
13,
2826,
1679,
7208,
15,
380,
954,
1846,
20265,
830,
273,
1029,
13559,
310,
1925,
36490,
4373,
348,
11201,
1306,
15604,
15,
831,
1617,
11852,
670,
337,
275,
6783,
952,
275,
954,
4343,
15,
401,
34206,
451,
4373,
348,
11201,
1306,
15604,
6634,
625,
7208,
275,
2176,
7625,
13,
1690,
3723,
16409,
266,
398,
275,
3684,
7531,
13,
5112,
32846,
13,
46900,
13,
285,
7198,
2224,
15
] |
How many people are affected by late-infantile neuronal ceroid lipofuscinosis ? | The prevalence of late-infantile NCL is unknown. Collectively, all forms of NCL affect an estimated 1 in 100,000 individuals worldwide. NCLs are more common in Finland, where approximately 1 in 12,500 individuals are affected. | [
2347,
1142,
952,
403,
5876,
407,
3563,
14,
2050,
386,
587,
16069,
15733,
1238,
5541,
1171,
316,
5620,
2433,
3736,
510,
8996,
273,
3563,
14,
2050,
386,
587,
427,
3207,
310,
7202,
15,
22729,
1242,
13,
512,
4948,
273,
427,
3207,
2818,
271,
5998,
337,
275,
2233,
13,
933,
4292,
11762,
15,
427,
3207,
84,
403,
625,
1846,
275,
25270,
13,
835,
5512,
337,
275,
1249,
13,
5388,
4292,
403,
5876,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
2347,
1142,
952,
403,
5876,
407,
3563,
14,
2050,
386,
587,
16069,
15733,
1238,
5541,
1171,
316,
5620,
2433,
3736,
510,
8996,
273,
3563,
14,
2050,
386,
587,
427,
3207,
310,
7202,
15,
22729,
1242,
13,
512,
4948,
273,
427,
3207,
2818,
271,
5998,
337,
275,
2233,
13,
933,
4292,
11762,
15,
427,
3207,
84,
403,
625,
1846,
275,
25270,
13,
835,
5512,
337,
275,
1249,
13,
5388,
4292,
403,
5876,
15
] |
What are the symptoms of Fibrous dysplasia ? | What are the symptoms of fibrous dysplasia? Fibrous dysplasia may cause no symptoms, mild symptoms, or severe symptoms. The most common symptoms are bone pain, bone deformities, fractures, and skin pigmentation differences (light brown spots on the skin). The problems that a person experiences depend on the specific bone(s) affected. For example, if the legs are of different lengths, they might limp when they walk; if the bones in the sinuses are affected, chronic sinus congestion may be a present. In rare cases, fibrous dysplasia is associated with abnormalities in the hormone-producing glands of the endocrine system. This may lead to precocious puberty, hyperthyroidism (excess thyroid hormone production), excess growth hormone (gigantism or acromegaly), and/or excess cortisol production (Cushing syndrome). If the face or skull bones are affected, hearing or vision loss may occur. | [
1276,
403,
253,
5917,
273,
401,
2560,
528,
48723,
3736,
1276,
403,
253,
5917,
273,
39751,
48723,
32,
401,
2560,
528,
48723,
778,
2847,
642,
5917,
13,
11134,
5917,
13,
390,
5460,
5917,
15,
380,
954,
1846,
5917,
403,
5961,
3075,
13,
5961,
22403,
1005,
13,
22877,
13,
285,
4808,
8393,
16977,
3910,
313,
3243,
8516,
13977,
327,
253,
4808,
481,
380,
3237,
326,
247,
1436,
8450,
3469,
327,
253,
2173,
5961,
9,
84,
10,
5876,
15,
1198,
1650,
13,
604,
253,
9246,
403,
273,
1027,
16095,
13,
597,
1537,
46169,
672,
597,
2940,
28,
604,
253,
14910,
275,
253,
6868,
5123,
403,
5876,
13,
6722,
22749,
35367,
778,
320,
247,
1246,
15,
496,
7520,
2219,
13,
39751,
48723,
310,
2330,
342,
19147,
275,
253,
14689,
14,
28916,
29108,
273,
253,
35527,
985,
15,
831,
778,
1421,
281,
3509,
49514,
13384,
39731,
13,
4373,
24085,
37739,
313,
911,
829,
17298,
14689,
3275,
582,
6714,
3116,
14689,
313,
72,
304,
386,
1204,
390,
913,
409,
909,
5242,
582,
285,
16,
263,
6714,
32996,
3275,
313,
36,
7849,
9237,
481,
1310,
253,
2454,
390,
19567,
14910,
403,
5876,
13,
4854,
390,
8113,
2957,
778,
2826,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
403,
253,
5917,
273,
401,
2560,
528,
48723,
3736,
1276,
403,
253,
5917,
273,
39751,
48723,
32,
401,
2560,
528,
48723,
778,
2847,
642,
5917,
13,
11134,
5917,
13,
390,
5460,
5917,
15,
380,
954,
1846,
5917,
403,
5961,
3075,
13,
5961,
22403,
1005,
13,
22877,
13,
285,
4808,
8393,
16977,
3910,
313,
3243,
8516,
13977,
327,
253,
4808,
481,
380,
3237,
326,
247,
1436,
8450,
3469,
327,
253,
2173,
5961,
9,
84,
10,
5876,
15,
1198,
1650,
13,
604,
253,
9246,
403,
273,
1027,
16095,
13,
597,
1537,
46169,
672,
597,
2940,
28,
604,
253,
14910,
275,
253,
6868,
5123,
403,
5876,
13,
6722,
22749,
35367,
778,
320,
247,
1246,
15,
496,
7520,
2219,
13,
39751,
48723,
310,
2330,
342,
19147,
275,
253,
14689,
14,
28916,
29108,
273,
253,
35527,
985,
15,
831,
778,
1421,
281,
3509,
49514,
13384,
39731,
13,
4373,
24085,
37739,
313,
911,
829,
17298,
14689,
3275,
582,
6714,
3116,
14689,
313,
72,
304,
386,
1204,
390,
913,
409,
909,
5242,
582,
285,
16,
263,
6714,
32996,
3275,
313,
36,
7849,
9237,
481,
1310,
253,
2454,
390,
19567,
14910,
403,
5876,
13,
4854,
390,
8113,
2957,
778,
2826,
15
] |
Is hemophilia inherited ? | Hemophilia A and hemophilia B are inherited in an X-linked recessive pattern. The genes associated with these conditions are located on the X chromosome, which is one of the two sex chromosomes. In males (who have only one X chromosome), one altered copy of the gene in each cell is sufficient to cause the condition. In females (who have two X chromosomes), a mutation would have to occur in both copies of the gene to cause the disorder. Because it is unlikely that females will have two altered copies of this gene, it is very rare for females to have hemophilia. A characteristic of X-linked inheritance is that fathers cannot pass X-linked traits to their sons. In X-linked recessive inheritance, a female with one altered copy of the gene in each cell is called a carrier. Carrier females have about half the usual amount of coagulation factor VIII or coagulation factor IX, which is generally enough for normal blood clotting. However, about 10 percent of carrier females have less than half the normal amount of one of these coagulation factors; these individuals are at risk for abnormal bleeding, particularly after an injury, surgery, or tooth extraction. | [
2513,
7492,
43639,
20265,
3736,
41,
358,
43639,
329,
285,
7492,
43639,
378,
403,
20265,
275,
271,
1594,
14,
16862,
24096,
422,
3102,
15,
380,
3608,
2330,
342,
841,
2515,
403,
4441,
327,
253,
1594,
15406,
13,
534,
310,
581,
273,
253,
767,
2825,
25112,
15,
496,
10798,
313,
10002,
452,
760,
581,
1594,
15406,
582,
581,
12059,
3491,
273,
253,
3320,
275,
1016,
894,
310,
4209,
281,
2847,
253,
1617,
15,
496,
10753,
313,
10002,
452,
767,
1594,
25112,
582,
247,
10577,
651,
452,
281,
2826,
275,
1097,
10125,
273,
253,
3320,
281,
2847,
253,
8984,
15,
4923,
352,
310,
11543,
326,
10753,
588,
452,
767,
12059,
10125,
273,
436,
3320,
13,
352,
310,
1077,
7520,
323,
10753,
281,
452,
7492,
43639,
15,
329,
8847,
273,
1594,
14,
16862,
24954,
310,
326,
24593,
2550,
1509,
1594,
14,
16862,
13795,
281,
616,
15196,
15,
50276,
688,
1594,
14,
16862,
24096,
422,
24954,
13,
247,
5343,
342,
581,
12059,
3491,
273,
253,
3320,
275,
1016,
894,
310,
1925,
247,
10289,
15,
2639,
4586,
10753,
452,
670,
2716,
253,
7312,
2408,
273,
35881,
2803,
29136,
390,
35881,
2803,
26821,
13,
534,
310,
3839,
2217,
323,
2622,
2614,
31301,
1076,
15,
1723,
13,
670,
884,
2558,
273,
10289,
10753,
452,
1679,
685,
2716,
253,
2622,
2408,
273,
581,
273,
841,
35881,
2616,
28,
841,
4292,
403,
387,
2495,
323,
10969,
14771,
13,
3782,
846,
271,
4975,
13,
5869,
13,
390,
15205,
11998,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
2513,
7492,
43639,
20265,
3736,
41,
358,
43639,
329,
285,
7492,
43639,
378,
403,
20265,
275,
271,
1594,
14,
16862,
24096,
422,
3102,
15,
380,
3608,
2330,
342,
841,
2515,
403,
4441,
327,
253,
1594,
15406,
13,
534,
310,
581,
273,
253,
767,
2825,
25112,
15,
496,
10798,
313,
10002,
452,
760,
581,
1594,
15406,
582,
581,
12059,
3491,
273,
253,
3320,
275,
1016,
894,
310,
4209,
281,
2847,
253,
1617,
15,
496,
10753,
313,
10002,
452,
767,
1594,
25112,
582,
247,
10577,
651,
452,
281,
2826,
275,
1097,
10125,
273,
253,
3320,
281,
2847,
253,
8984,
15,
4923,
352,
310,
11543,
326,
10753,
588,
452,
767,
12059,
10125,
273,
436,
3320,
13,
352,
310,
1077,
7520,
323,
10753,
281,
452,
7492,
43639,
15,
329,
8847,
273,
1594,
14,
16862,
24954,
310,
326,
24593,
2550,
1509,
1594,
14,
16862,
13795,
281,
616,
15196,
15,
50276,
688,
1594,
14,
16862,
24096,
422,
24954,
13,
247,
5343,
342,
581,
12059,
3491,
273,
253,
3320,
275,
1016,
894,
310,
1925,
247,
10289,
15,
2639,
4586,
10753,
452,
670,
2716,
253,
7312,
2408,
273,
35881,
2803,
29136,
390,
35881,
2803,
26821,
13,
534,
310,
3839,
2217,
323,
2622,
2614,
31301,
1076,
15,
1723,
13,
670,
884,
2558,
273,
10289,
10753,
452,
1679,
685,
2716,
253,
2622,
2408,
273,
581,
273,
841,
35881,
2616,
28,
841,
4292,
403,
387,
2495,
323,
10969,
14771,
13,
3782,
846,
271,
4975,
13,
5869,
13,
390,
15205,
11998,
15
] |
What are the symptoms of Syringoma ? | What are the signs and symptoms of Syringoma? The Human Phenotype Ontology provides the following list of signs and symptoms for Syringoma. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Abnormality of the skin - Autosomal dominant inheritance - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common. | [
1276,
403,
253,
5917,
273,
5619,
804,
3691,
3736,
1276,
403,
253,
7871,
285,
5917,
273,
5619,
804,
3691,
32,
380,
8801,
34689,
5174,
15195,
1497,
3400,
253,
1563,
1618,
273,
7871,
285,
5917,
323,
5619,
804,
3691,
15,
1310,
253,
1491,
310,
2130,
13,
253,
2829,
2708,
3797,
849,
2223,
253,
19831,
310,
2326,
275,
952,
342,
436,
1617,
15,
1422,
476,
897,
253,
3050,
1282,
25263,
8710,
26372,
281,
1007,
598,
253,
14308,
323,
841,
3739,
2426,
15,
8714,
84,
285,
40561,
3056,
17274,
13954,
1180,
273,
1363,
313,
9453,
2130,
10,
3506,
12850,
1319,
273,
253,
4808,
428,
5271,
13304,
11360,
24954,
428,
380,
8801,
34689,
5174,
15195,
1497,
313,
41,
5964,
10,
556,
5728,
1491,
327,
849,
2223,
247,
861,
390,
19831,
6634,
275,
247,
1617,
15,
18770,
273,
436,
1491,
3249,
432,
2207,
15671,
292,
13,
247,
5284,
7520,
2728,
5447,
15,
380,
4294,
273,
247,
861,
390,
19831,
310,
3798,
7117,
347,
247,
7227,
6642,
273,
253,
7155,
273,
1363,
665,
452,
326,
4735,
15,
380,
4294,
778,
671,
320,
7117,
347,
247,
6919,
15,
380,
806,
1180,
273,
253,
6919,
310,
849,
1142,
952,
574,
253,
19831,
13,
285,
253,
1273,
1180,
310,
253,
2264,
1180,
273,
952,
665,
497,
6730,
275,
581,
1263,
15,
1198,
1650,
13,
247,
4294,
273,
2030,
16,
1099,
2097,
326,
275,
247,
1263,
273,
2030,
952,
512,
1363,
497,
1119,
281,
452,
326,
19831,
15,
4923,
841,
11383,
403,
1754,
327,
247,
2173,
1263,
13,
253,
17711,
778,
320,
1027,
604,
1529,
1387,
273,
1363,
403,
6730,
15,
13168,
13,
642,
1491,
327,
4294,
310,
2130,
15,
496,
841,
2219,
13,
253,
861,
390,
19831,
778,
320,
7520,
390,
1846,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
403,
253,
5917,
273,
5619,
804,
3691,
3736,
1276,
403,
253,
7871,
285,
5917,
273,
5619,
804,
3691,
32,
380,
8801,
34689,
5174,
15195,
1497,
3400,
253,
1563,
1618,
273,
7871,
285,
5917,
323,
5619,
804,
3691,
15,
1310,
253,
1491,
310,
2130,
13,
253,
2829,
2708,
3797,
849,
2223,
253,
19831,
310,
2326,
275,
952,
342,
436,
1617,
15,
1422,
476,
897,
253,
3050,
1282,
25263,
8710,
26372,
281,
1007,
598,
253,
14308,
323,
841,
3739,
2426,
15,
8714,
84,
285,
40561,
3056,
17274,
13954,
1180,
273,
1363,
313,
9453,
2130,
10,
3506,
12850,
1319,
273,
253,
4808,
428,
5271,
13304,
11360,
24954,
428,
380,
8801,
34689,
5174,
15195,
1497,
313,
41,
5964,
10,
556,
5728,
1491,
327,
849,
2223,
247,
861,
390,
19831,
6634,
275,
247,
1617,
15,
18770,
273,
436,
1491,
3249,
432,
2207,
15671,
292,
13,
247,
5284,
7520,
2728,
5447,
15,
380,
4294,
273,
247,
861,
390,
19831,
310,
3798,
7117,
347,
247,
7227,
6642,
273,
253,
7155,
273,
1363,
665,
452,
326,
4735,
15,
380,
4294,
778,
671,
320,
7117,
347,
247,
6919,
15,
380,
806,
1180,
273,
253,
6919,
310,
849,
1142,
952,
574,
253,
19831,
13,
285,
253,
1273,
1180,
310,
253,
2264,
1180,
273,
952,
665,
497,
6730,
275,
581,
1263,
15,
1198,
1650,
13,
247,
4294,
273,
2030,
16,
1099,
2097,
326,
275,
247,
1263,
273,
2030,
952,
512,
1363,
497,
1119,
281,
452,
326,
19831,
15,
4923,
841,
11383,
403,
1754,
327,
247,
2173,
1263,
13,
253,
17711,
778,
320,
1027,
604,
1529,
1387,
273,
1363,
403,
6730,
15,
13168,
13,
642,
1491,
327,
4294,
310,
2130,
15,
496,
841,
2219,
13,
253,
861,
390,
19831,
778,
320,
7520,
390,
1846,
15
] |
What are the symptoms of Jervell and Lange-Nielsen syndrome 2 ? | What are the signs and symptoms of Jervell and Lange-Nielsen syndrome 2? The Human Phenotype Ontology provides the following list of signs and symptoms for Jervell and Lange-Nielsen syndrome 2. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Autosomal recessive inheritance - Prolonged QT interval - Sensorineural hearing impairment - Syncope - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common. | [
1276,
403,
253,
5917,
273,
500,
677,
437,
285,
49890,
14,
47,
37172,
9237,
374,
3736,
1276,
403,
253,
7871,
285,
5917,
273,
500,
677,
437,
285,
49890,
14,
47,
37172,
9237,
374,
32,
380,
8801,
34689,
5174,
15195,
1497,
3400,
253,
1563,
1618,
273,
7871,
285,
5917,
323,
500,
677,
437,
285,
49890,
14,
47,
37172,
9237,
374,
15,
1310,
253,
1491,
310,
2130,
13,
253,
2829,
2708,
3797,
849,
2223,
253,
19831,
310,
2326,
275,
952,
342,
436,
1617,
15,
1422,
476,
897,
253,
3050,
1282,
25263,
8710,
26372,
281,
1007,
598,
253,
14308,
323,
841,
3739,
2426,
15,
8714,
84,
285,
40561,
3056,
17274,
13954,
1180,
273,
1363,
313,
9453,
2130,
10,
5271,
13304,
24096,
422,
24954,
428,
46484,
543,
264,
48703,
7726,
428,
322,
11313,
460,
1546,
4854,
15151,
428,
322,
6665,
1714,
428,
380,
8801,
34689,
5174,
15195,
1497,
313,
41,
5964,
10,
556,
5728,
1491,
327,
849,
2223,
247,
861,
390,
19831,
6634,
275,
247,
1617,
15,
18770,
273,
436,
1491,
3249,
432,
2207,
15671,
292,
13,
247,
5284,
7520,
2728,
5447,
15,
380,
4294,
273,
247,
861,
390,
19831,
310,
3798,
7117,
347,
247,
7227,
6642,
273,
253,
7155,
273,
1363,
665,
452,
326,
4735,
15,
380,
4294,
778,
671,
320,
7117,
347,
247,
6919,
15,
380,
806,
1180,
273,
253,
6919,
310,
849,
1142,
952,
574,
253,
19831,
13,
285,
253,
1273,
1180,
310,
253,
2264,
1180,
273,
952,
665,
497,
6730,
275,
581,
1263,
15,
1198,
1650,
13,
247,
4294,
273,
2030,
16,
1099,
2097,
326,
275,
247,
1263,
273,
2030,
952,
512,
1363,
497,
1119,
281,
452,
326,
19831,
15,
4923,
841,
11383,
403,
1754,
327,
247,
2173,
1263,
13,
253,
17711,
778,
320,
1027,
604,
1529,
1387,
273,
1363,
403,
6730,
15,
13168,
13,
642,
1491,
327,
4294,
310,
2130,
15,
496,
841,
2219,
13,
253,
861,
390,
19831,
778,
320,
7520,
390,
1846,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
403,
253,
5917,
273,
500,
677,
437,
285,
49890,
14,
47,
37172,
9237,
374,
3736,
1276,
403,
253,
7871,
285,
5917,
273,
500,
677,
437,
285,
49890,
14,
47,
37172,
9237,
374,
32,
380,
8801,
34689,
5174,
15195,
1497,
3400,
253,
1563,
1618,
273,
7871,
285,
5917,
323,
500,
677,
437,
285,
49890,
14,
47,
37172,
9237,
374,
15,
1310,
253,
1491,
310,
2130,
13,
253,
2829,
2708,
3797,
849,
2223,
253,
19831,
310,
2326,
275,
952,
342,
436,
1617,
15,
1422,
476,
897,
253,
3050,
1282,
25263,
8710,
26372,
281,
1007,
598,
253,
14308,
323,
841,
3739,
2426,
15,
8714,
84,
285,
40561,
3056,
17274,
13954,
1180,
273,
1363,
313,
9453,
2130,
10,
5271,
13304,
24096,
422,
24954,
428,
46484,
543,
264,
48703,
7726,
428,
322,
11313,
460,
1546,
4854,
15151,
428,
322,
6665,
1714,
428,
380,
8801,
34689,
5174,
15195,
1497,
313,
41,
5964,
10,
556,
5728,
1491,
327,
849,
2223,
247,
861,
390,
19831,
6634,
275,
247,
1617,
15,
18770,
273,
436,
1491,
3249,
432,
2207,
15671,
292,
13,
247,
5284,
7520,
2728,
5447,
15,
380,
4294,
273,
247,
861,
390,
19831,
310,
3798,
7117,
347,
247,
7227,
6642,
273,
253,
7155,
273,
1363,
665,
452,
326,
4735,
15,
380,
4294,
778,
671,
320,
7117,
347,
247,
6919,
15,
380,
806,
1180,
273,
253,
6919,
310,
849,
1142,
952,
574,
253,
19831,
13,
285,
253,
1273,
1180,
310,
253,
2264,
1180,
273,
952,
665,
497,
6730,
275,
581,
1263,
15,
1198,
1650,
13,
247,
4294,
273,
2030,
16,
1099,
2097,
326,
275,
247,
1263,
273,
2030,
952,
512,
1363,
497,
1119,
281,
452,
326,
19831,
15,
4923,
841,
11383,
403,
1754,
327,
247,
2173,
1263,
13,
253,
17711,
778,
320,
1027,
604,
1529,
1387,
273,
1363,
403,
6730,
15,
13168,
13,
642,
1491,
327,
4294,
310,
2130,
15,
496,
841,
2219,
13,
253,
861,
390,
19831,
778,
320,
7520,
390,
1846,
15
] |
What are the symptoms of Fukuyama type muscular dystrophy ? | What are the signs and symptoms of Fukuyama type muscular dystrophy? The Human Phenotype Ontology provides the following list of signs and symptoms for Fukuyama type muscular dystrophy. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Exaggerated startle response 5% Holoprosencephaly 5% Retinal dysplasia 5% Agenesis of corpus callosum - Areflexia - Atria septal defect - Autosomal recessive inheritance - Calf muscle hypertrophy - Cataract - Cerebellar cyst - Cerebellar hypoplasia - Congenital muscular dystrophy - Elevated serum creatine phosphokinase - Encephalocele - Flexion contracture - Hydrocephalus - Hypermetropia - Hypoplasia of the brainstem - Hypoplasia of the pyramidal tract - Infantile onset - Intellectual disability - Microphthalmia - Muscle weakness - Muscular hypotonia - Myocardial fibrosis - Myopia - Optic atrophy - Pachygyria - Polymicrogyria - Pulmonic stenosis - Respiratory insufficiency - Retinal detachment - Scoliosis - Seizures - Skeletal muscle atrophy - Spinal rigidity - Strabismus - Transposition of the great arteries - Type II lissencephaly - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common. | [
1276,
403,
253,
5917,
273,
34990,
7352,
2902,
1511,
27602,
32692,
13354,
3736,
1276,
403,
253,
7871,
285,
5917,
273,
34990,
7352,
2902,
1511,
27602,
32692,
13354,
32,
380,
8801,
34689,
5174,
15195,
1497,
3400,
253,
1563,
1618,
273,
7871,
285,
5917,
323,
34990,
7352,
2902,
1511,
27602,
32692,
13354,
15,
1310,
253,
1491,
310,
2130,
13,
253,
2829,
2708,
3797,
849,
2223,
253,
19831,
310,
2326,
275,
952,
342,
436,
1617,
15,
1422,
476,
897,
253,
3050,
1282,
25263,
8710,
26372,
281,
1007,
598,
253,
14308,
323,
841,
3739,
2426,
15,
8714,
84,
285,
40561,
3056,
17274,
13954,
1180,
273,
1363,
313,
9453,
2130,
10,
1889,
7215,
456,
1265,
282,
2380,
608,
6,
4716,
412,
2921,
566,
545,
5242,
608,
6,
6724,
989,
48723,
608,
6,
329,
47551,
273,
20689,
1067,
375,
360,
428,
329,
709,
1591,
571,
428,
2058,
5182,
22688,
267,
7071,
428,
5271,
13304,
24096,
422,
24954,
428,
330,
2103,
6616,
37416,
428,
12441,
274,
514,
428,
330,
11892,
67,
8739,
26242,
428,
330,
11892,
67,
8739,
3500,
4488,
13411,
428,
4731,
257,
1562,
27602,
32692,
13354,
428,
13173,
87,
456,
6658,
2833,
460,
5124,
25980,
511,
428,
3035,
336,
545,
12584,
44033,
428,
34340,
279,
3310,
459,
428,
26992,
25088,
316,
428,
25411,
3899,
1658,
571,
428,
25295,
4488,
13411,
273,
253,
3998,
852,
428,
25295,
4488,
13411,
273,
253,
25874,
11421,
10649,
428,
13160,
386,
587,
11653,
428,
17545,
37246,
12564,
428,
10929,
1658,
18563,
15604,
428,
4878,
2148,
14855,
428,
4878,
2772,
37251,
9409,
428,
2752,
50173,
19990,
428,
2752,
30147,
428,
12551,
280,
34512,
428,
367,
24814,
4233,
5182,
428,
3130,
1105,
1813,
4233,
5182,
428,
26386,
2163,
280,
29940,
428,
2213,
48208,
39975,
428,
6724,
989,
36832,
428,
1810,
10424,
2433,
428,
1023,
478,
980,
428,
322,
30554,
6616,
34512,
428,
2101,
989,
40350,
428,
7962,
357,
47004,
428,
4480,
3321,
273,
253,
1270,
24908,
428,
8078,
3719,
298,
739,
566,
545,
5242,
428,
380,
8801,
34689,
5174,
15195,
1497,
313,
41,
5964,
10,
556,
5728,
1491,
327,
849,
2223,
247,
861,
390,
19831,
6634,
275,
247,
1617,
15,
18770,
273,
436,
1491,
3249,
432,
2207,
15671,
292,
13,
247,
5284,
7520,
2728,
5447,
15,
380,
4294,
273,
247,
861,
390,
19831,
310,
3798,
7117,
347,
247,
7227,
6642,
273,
253,
7155,
273,
1363,
665,
452,
326,
4735,
15,
380,
4294,
778,
671,
320,
7117,
347,
247,
6919,
15,
380,
806,
1180,
273,
253,
6919,
310,
849,
1142,
952,
574,
253,
19831,
13,
285,
253,
1273,
1180,
310,
253,
2264,
1180,
273,
952,
665,
497,
6730,
275,
581,
1263,
15,
1198,
1650,
13,
247,
4294,
273,
2030,
16,
1099,
2097,
326,
275,
247,
1263,
273,
2030,
952,
512,
1363,
497,
1119,
281,
452,
326,
19831,
15,
4923,
841,
11383,
403,
1754,
327,
247,
2173,
1263,
13,
253,
17711,
778,
320,
1027,
604,
1529,
1387,
273,
1363,
403,
6730,
15,
13168,
13,
642,
1491,
327,
4294,
310,
2130,
15,
496,
841,
2219,
13,
253,
861,
390,
19831,
778,
320,
7520,
390,
1846,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
403,
253,
5917,
273,
34990,
7352,
2902,
1511,
27602,
32692,
13354,
3736,
1276,
403,
253,
7871,
285,
5917,
273,
34990,
7352,
2902,
1511,
27602,
32692,
13354,
32,
380,
8801,
34689,
5174,
15195,
1497,
3400,
253,
1563,
1618,
273,
7871,
285,
5917,
323,
34990,
7352,
2902,
1511,
27602,
32692,
13354,
15,
1310,
253,
1491,
310,
2130,
13,
253,
2829,
2708,
3797,
849,
2223,
253,
19831,
310,
2326,
275,
952,
342,
436,
1617,
15,
1422,
476,
897,
253,
3050,
1282,
25263,
8710,
26372,
281,
1007,
598,
253,
14308,
323,
841,
3739,
2426,
15,
8714,
84,
285,
40561,
3056,
17274,
13954,
1180,
273,
1363,
313,
9453,
2130,
10,
1889,
7215,
456,
1265,
282,
2380,
608,
6,
4716,
412,
2921,
566,
545,
5242,
608,
6,
6724,
989,
48723,
608,
6,
329,
47551,
273,
20689,
1067,
375,
360,
428,
329,
709,
1591,
571,
428,
2058,
5182,
22688,
267,
7071,
428,
5271,
13304,
24096,
422,
24954,
428,
330,
2103,
6616,
37416,
428,
12441,
274,
514,
428,
330,
11892,
67,
8739,
26242,
428,
330,
11892,
67,
8739,
3500,
4488,
13411,
428,
4731,
257,
1562,
27602,
32692,
13354,
428,
13173,
87,
456,
6658,
2833,
460,
5124,
25980,
511,
428,
3035,
336,
545,
12584,
44033,
428,
34340,
279,
3310,
459,
428,
26992,
25088,
316,
428,
25411,
3899,
1658,
571,
428,
25295,
4488,
13411,
273,
253,
3998,
852,
428,
25295,
4488,
13411,
273,
253,
25874,
11421,
10649,
428,
13160,
386,
587,
11653,
428,
17545,
37246,
12564,
428,
10929,
1658,
18563,
15604,
428,
4878,
2148,
14855,
428,
4878,
2772,
37251,
9409,
428,
2752,
50173,
19990,
428,
2752,
30147,
428,
12551,
280,
34512,
428,
367,
24814,
4233,
5182,
428,
3130,
1105,
1813,
4233,
5182,
428,
26386,
2163,
280,
29940,
428,
2213,
48208,
39975,
428,
6724,
989,
36832,
428,
1810,
10424,
2433,
428,
1023,
478,
980,
428,
322,
30554,
6616,
34512,
428,
2101,
989,
40350,
428,
7962,
357,
47004,
428,
4480,
3321,
273,
253,
1270,
24908,
428,
8078,
3719,
298,
739,
566,
545,
5242,
428,
380,
8801,
34689,
5174,
15195,
1497,
313,
41,
5964,
10,
556,
5728,
1491,
327,
849,
2223,
247,
861,
390,
19831,
6634,
275,
247,
1617,
15,
18770,
273,
436,
1491,
3249,
432,
2207,
15671,
292,
13,
247,
5284,
7520,
2728,
5447,
15,
380,
4294,
273,
247,
861,
390,
19831,
310,
3798,
7117,
347,
247,
7227,
6642,
273,
253,
7155,
273,
1363,
665,
452,
326,
4735,
15,
380,
4294,
778,
671,
320,
7117,
347,
247,
6919,
15,
380,
806,
1180,
273,
253,
6919,
310,
849,
1142,
952,
574,
253,
19831,
13,
285,
253,
1273,
1180,
310,
253,
2264,
1180,
273,
952,
665,
497,
6730,
275,
581,
1263,
15,
1198,
1650,
13,
247,
4294,
273,
2030,
16,
1099,
2097,
326,
275,
247,
1263,
273,
2030,
952,
512,
1363,
497,
1119,
281,
452,
326,
19831,
15,
4923,
841,
11383,
403,
1754,
327,
247,
2173,
1263,
13,
253,
17711,
778,
320,
1027,
604,
1529,
1387,
273,
1363,
403,
6730,
15,
13168,
13,
642,
1491,
327,
4294,
310,
2130,
15,
496,
841,
2219,
13,
253,
861,
390,
19831,
778,
320,
7520,
390,
1846,
15
] |
What is (are) ALG6-congenital disorder of glycosylation ? | ALG6-congenital disorder of glycosylation (ALG6-CDG, also known as congenital disorder of glycosylation type Ic) is an inherited condition that affects many parts of the body. The signs and symptoms of ALG6-CDG vary widely among people with the condition. Individuals with ALG6-CDG typically develop signs and symptoms of the condition during infancy. They may have difficulty gaining weight and growing at the expected rate (failure to thrive). Affected infants often have weak muscle tone (hypotonia) and developmental delay. People with ALG6-CDG may have seizures, problems with coordination and balance (ataxia), or stroke-like episodes that involve an extreme lack of energy (lethargy) and temporary paralysis. They may also develop blood clotting disorders. Some individuals with ALG6-CDG have eye abnormalities including eyes that do not look in the same direction (strabismus) and an eye disorder called retinitis pigmentosa, which causes vision loss. Females with ALG6-CDG have hypergonadotropic hypogonadism, which affects the production of hormones that direct sexual development. As a result, most females with ALG6-CDG do not go through puberty. | [
1276,
310,
313,
609,
10,
6589,
40,
23,
14,
14829,
257,
1562,
8984,
273,
26988,
16499,
3736,
1556,
40,
23,
14,
14829,
257,
1562,
8984,
273,
26988,
16499,
313,
1556,
40,
23,
14,
3717,
40,
13,
671,
1929,
347,
28296,
8984,
273,
26988,
16499,
1511,
309,
68,
10,
310,
271,
20265,
1617,
326,
11852,
1142,
4243,
273,
253,
2133,
15,
380,
7871,
285,
5917,
273,
6589,
40,
23,
14,
3717,
40,
6889,
7561,
2190,
952,
342,
253,
1617,
15,
50276,
38861,
84,
342,
6589,
40,
23,
14,
3717,
40,
5431,
1287,
7871,
285,
5917,
273,
253,
1617,
1309,
42986,
15,
1583,
778,
452,
10183,
21896,
2801,
285,
5675,
387,
253,
3264,
2281,
313,
33699,
281,
34298,
481,
329,
21494,
15330,
2223,
452,
5075,
6616,
10541,
313,
1994,
11714,
9409,
10,
285,
16743,
5778,
15,
50276,
8836,
342,
6589,
40,
23,
14,
3717,
40,
778,
452,
26347,
13,
3237,
342,
19915,
285,
6654,
313,
682,
36592,
582,
390,
9980,
14,
3022,
13305,
326,
6388,
271,
9559,
3480,
273,
2341,
313,
282,
394,
1662,
90,
10,
285,
11287,
45050,
15,
1583,
778,
671,
1287,
2614,
31301,
1076,
9360,
15,
3808,
4292,
342,
6589,
40,
23,
14,
3717,
40,
452,
5130,
19147,
1690,
2927,
326,
513,
417,
1007,
275,
253,
1072,
3884,
313,
1344,
357,
47004,
10,
285,
271,
5130,
8984,
1925,
851,
46999,
30448,
6859,
13,
534,
5997,
8113,
2957,
15,
43299,
2339,
342,
6589,
40,
23,
14,
3717,
40,
452,
4373,
19835,
324,
32801,
3500,
38931,
324,
1204,
13,
534,
11852,
253,
3275,
273,
23884,
326,
1480,
5615,
2440,
15,
1284,
247,
906,
13,
954,
10753,
342,
6589,
40,
23,
14,
3717,
40,
513,
417,
564,
949,
13384,
39731,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
310,
313,
609,
10,
6589,
40,
23,
14,
14829,
257,
1562,
8984,
273,
26988,
16499,
3736,
1556,
40,
23,
14,
14829,
257,
1562,
8984,
273,
26988,
16499,
313,
1556,
40,
23,
14,
3717,
40,
13,
671,
1929,
347,
28296,
8984,
273,
26988,
16499,
1511,
309,
68,
10,
310,
271,
20265,
1617,
326,
11852,
1142,
4243,
273,
253,
2133,
15,
380,
7871,
285,
5917,
273,
6589,
40,
23,
14,
3717,
40,
6889,
7561,
2190,
952,
342,
253,
1617,
15,
50276,
38861,
84,
342,
6589,
40,
23,
14,
3717,
40,
5431,
1287,
7871,
285,
5917,
273,
253,
1617,
1309,
42986,
15,
1583,
778,
452,
10183,
21896,
2801,
285,
5675,
387,
253,
3264,
2281,
313,
33699,
281,
34298,
481,
329,
21494,
15330,
2223,
452,
5075,
6616,
10541,
313,
1994,
11714,
9409,
10,
285,
16743,
5778,
15,
50276,
8836,
342,
6589,
40,
23,
14,
3717,
40,
778,
452,
26347,
13,
3237,
342,
19915,
285,
6654,
313,
682,
36592,
582,
390,
9980,
14,
3022,
13305,
326,
6388,
271,
9559,
3480,
273,
2341,
313,
282,
394,
1662,
90,
10,
285,
11287,
45050,
15,
1583,
778,
671,
1287,
2614,
31301,
1076,
9360,
15,
3808,
4292,
342,
6589,
40,
23,
14,
3717,
40,
452,
5130,
19147,
1690,
2927,
326,
513,
417,
1007,
275,
253,
1072,
3884,
313,
1344,
357,
47004,
10,
285,
271,
5130,
8984,
1925,
851,
46999,
30448,
6859,
13,
534,
5997,
8113,
2957,
15,
43299,
2339,
342,
6589,
40,
23,
14,
3717,
40,
452,
4373,
19835,
324,
32801,
3500,
38931,
324,
1204,
13,
534,
11852,
253,
3275,
273,
23884,
326,
1480,
5615,
2440,
15,
1284,
247,
906,
13,
954,
10753,
342,
6589,
40,
23,
14,
3717,
40,
513,
417,
564,
949,
13384,
39731,
15
] |
What are the symptoms of Bartter syndrome ? | What are the signs and symptoms of Bartter syndrome? The signs and symptoms associated with Bartter syndrome can vary depending on the form of Bartter syndrome an affected individual has. The antenatal forms (beginning before birth) can be life-threatening, while the classical form, beginning in early childhood, tends to be less severe. The antenatal forms of Bartter syndrome (types I, II and IV) may first be characterized by abnormally high levels of amniotic fluid surrounding the affected fetus (polyhydramnios); premature delivery; and possibly life-threatening salt (sodium-chloride) loss. Affected newborns may have fever, vomiting, diarrhea, failure to thrive, delayed growth, intellectual disability, and/or distinctive facial features (triangular face, prominent forehead, large eyes, protruding ears, and drooping mouth). Individuals with type IV may also have sensorineural deafness (hearing loss caused by abnormalities in the inner ear). Classical Bartter syndrome typically becomes apparent in infancy and is characterized by failure to thrive and constipation in the first year of life. Symptoms may include salt craving, fatigue, muscle weakness, growth delay and developmental delay. Loss of excess sodium chloride through the urine can lead to dehydration, constipation, and increased urine production (polyuria). Loss of excess calcium through the urine (hypercalciuria) can cause weakening of the bones (osteopenia). When this excess calcium becomes deposited in the kidneys, tissue in the kidneys can become hardened (nephrocalcinosis). Low levels of potassium in the blood (hypokalemia) cause the muscle weakness, cramping, and fatigue in affected individuals. The Human Phenotype Ontology provides the following list of signs and symptoms for Bartter syndrome. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Abnormal renal physiology 90% Abnormality of metabolism/homeostasis 90% Short stature 90% Hypocalciuria 7.5% Hypomagnesemia 7.5% Abnormality of the choroid - Abnormality of the retinal vasculature - Abnormality of the sclera - Autosomal recessive inheritance - Chondrocalcinosis - Congenital onset - Constipation - Decreased glomerular filtration rate - Dehydration - Diarrhea - Edema - Failure to thrive - Fetal polyuria - Fever - Frontal bossing - Generalized muscle weakness - Global glomerulosclerosis - Heterogeneous - Hydrops fetalis - Hyperactive renin-angiotensin system - Hyperaldosteronism - Hypercalciuria - Hyperchloridura - Hypernatriuria - Hyperprostaglandinuria - Hypochloremia - Hypokalemia - Hypokalemic hypochloremic metabolic alkalosis - Hypokalemic metabolic alkalosis - Hyponatremia - Hyporeflexia - Hyposthenuria - Hypotension - Impaired platelet aggregation - Impaired reabsorption of chloride - Increased circulating renin level - Increased serum prostaglandin E2 - Increased urinary potassium - Intellectual disability - Large eyes - Low-to-normal blood pressure - Macrocephaly - Macrotia - Motor delay - Muscle cramps - Muscular hypotonia - Nephrocalcinosis - Osteopenia - Paresthesia - Polydipsia - Polyhydramnios - Polyuria - Premature birth - Prominent forehead - Reduced renal corticomedullary differentiation - Renal insufficiency - Renal juxtaglomerular cell hypertrophy/hyperplasia - Renal potassium wasting - Renal salt wasting - Seizures - Sensorineural hearing impairment - Small for gestational age - Tetany - Triangular face - Tubulointerstitial fibrosis - Vomiting - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common. | [
1276,
403,
253,
5917,
273,
17486,
350,
9237,
3736,
1276,
403,
253,
7871,
285,
5917,
273,
17486,
350,
9237,
32,
380,
7871,
285,
5917,
2330,
342,
17486,
350,
9237,
476,
6889,
7293,
327,
253,
830,
273,
17486,
350,
9237,
271,
5876,
2060,
556,
15,
380,
1331,
257,
3165,
4948,
313,
2043,
920,
1078,
4201,
10,
476,
320,
1495,
14,
33897,
13,
1223,
253,
8946,
830,
13,
5068,
275,
2393,
11948,
13,
14280,
281,
320,
1679,
5460,
15,
380,
1331,
257,
3165,
4948,
273,
17486,
350,
9237,
313,
10706,
309,
13,
3719,
285,
8019,
10,
778,
806,
320,
7943,
407,
32459,
595,
1029,
2308,
273,
717,
8311,
3875,
6514,
8704,
253,
5876,
36866,
313,
18372,
22034,
3358,
79,
3783,
558,
20346,
6742,
28,
285,
6830,
1495,
14,
33897,
7043,
313,
84,
26796,
14,
19700,
504,
10,
2957,
15,
329,
21494,
48842,
778,
452,
15198,
13,
33510,
13,
30709,
13,
4433,
281,
34298,
13,
13444,
3116,
13,
12720,
12564,
13,
285,
16,
263,
21488,
17754,
3386,
313,
12512,
12406,
2454,
13,
11906,
22977,
13,
1781,
2927,
13,
26322,
27951,
13628,
13,
285,
3926,
18225,
6208,
481,
40788,
342,
1511,
8019,
778,
671,
452,
8468,
460,
1546,
26057,
1255,
313,
31629,
2957,
4269,
407,
19147,
275,
253,
6703,
2472,
481,
38237,
17486,
350,
9237,
5431,
4916,
5165,
275,
42986,
285,
310,
7943,
407,
4433,
281,
34298,
285,
1030,
32713,
275,
253,
806,
807,
273,
1495,
15,
40561,
3056,
778,
2486,
7043,
45671,
13,
18693,
13,
6616,
14855,
13,
3116,
5778,
285,
16743,
5778,
15,
28622,
273,
6714,
11914,
21437,
949,
253,
16327,
476,
1421,
281,
45115,
13,
1030,
32713,
13,
285,
2559,
16327,
3275,
313,
18372,
21576,
481,
28622,
273,
6714,
11672,
949,
253,
16327,
313,
27049,
1179,
5297,
21576,
10,
476,
2847,
49060,
273,
253,
14910,
313,
35279,
32889,
481,
2091,
436,
6714,
11672,
4916,
17063,
275,
253,
33193,
13,
4408,
275,
253,
33193,
476,
2489,
43656,
313,
570,
545,
29536,
5620,
2433,
481,
11578,
2308,
273,
23160,
275,
253,
2614,
313,
35040,
536,
267,
9512,
10,
2847,
253,
6616,
14855,
13,
1531,
42956,
13,
285,
18693,
275,
5876,
4292,
15,
380,
8801,
34689,
5174,
15195,
1497,
3400,
253,
1563,
1618,
273,
7871,
285,
5917,
323,
17486,
350,
9237,
15,
1310,
253,
1491,
310,
2130,
13,
253,
2829,
2708,
3797,
849,
2223,
253,
19831,
310,
2326,
275,
952,
342,
436,
1617,
15,
1422,
476,
897,
253,
3050,
1282,
25263,
8710,
26372,
281,
1007,
598,
253,
14308,
323,
841,
3739,
2426,
15,
8714,
84,
285,
40561,
3056,
17274,
13954,
1180,
273,
1363,
313,
9453,
2130,
10,
3506,
6320,
10919,
32337,
5091,
6,
3506,
12850,
1319,
273,
11082,
16,
9511,
493,
4914,
5091,
6,
14196,
45540,
5091,
6,
25295,
3100,
5297,
21576,
818,
15,
22,
6,
25295,
297,
1530,
265,
9512,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
30811,
1238,
428,
3506,
12850,
1319,
273,
253,
22043,
35244,
1177,
428,
3506,
12850,
1319,
273,
253,
256,
498,
3525,
428,
5271,
13304,
24096,
422,
24954,
428,
775,
857,
29536,
5620,
2433,
428,
4731,
257,
1562,
11653,
428,
14869,
32713,
428,
44398,
833,
41418,
24077,
2281,
428,
1605,
37249,
428,
6129,
28487,
428,
3619,
8895,
428,
32104,
281,
34298,
428,
401,
16190,
3488,
21576,
428,
401,
972,
428,
1879,
8226,
12145,
272,
428,
4214,
1025,
6616,
14855,
428,
11841,
28516,
41575,
18320,
428,
49125,
10553,
428,
26992,
793,
16728,
261,
428,
25411,
4507,
3816,
249,
14,
606,
33721,
985,
428,
25411,
8950,
7337,
251,
1204,
428,
25411,
1179,
5297,
21576,
428,
25411,
19700,
301,
5650,
428,
25411,
25781,
363,
21576,
428,
25411,
856,
296,
38324,
249,
21576,
428,
25295,
3770,
77,
4362,
571,
428,
25295,
536,
267,
9512,
428,
25295,
536,
267,
11060,
3500,
3770,
77,
4362,
280,
10761,
42008,
2433,
428,
25295,
536,
267,
11060,
10761,
42008,
2433,
428,
25295,
251,
255,
46739,
428,
25295,
410,
23210,
571,
428,
25295,
493,
864,
21576,
428,
25295,
302,
2452,
428,
16009,
12260,
21039,
20828,
428,
16009,
12260,
294,
47119,
273,
21437,
428,
32483,
19682,
3816,
249,
1268,
428,
32483,
6658,
46400,
249,
444,
19,
428,
32483,
19006,
23160,
428,
17545,
37246,
12564,
428,
21157,
2927,
428,
11578,
14,
936,
14,
6320,
2614,
3473,
428,
5602,
287,
336,
545,
5242,
428,
5602,
8601,
571,
428,
18521,
5778,
428,
4878,
2148,
1531,
11441,
428,
4878,
2772,
37251,
9409,
428,
3532,
545,
29536,
5620,
2433,
428,
49000,
32889,
428,
367,
4885,
19257,
428,
3130,
10120,
2824,
571,
428,
18371,
22034,
3358,
79,
3783,
428,
18371,
21576,
428,
13343,
1177,
4201,
428,
13798,
14622,
22977,
428,
4410,
5504,
10919,
26505,
14944,
46909,
9827,
428,
12751,
267,
39975,
428,
12751,
267,
47806,
356,
77,
8056,
792,
894,
37416,
16,
27049,
24506,
428,
12751,
267,
23160,
31160,
428,
12751,
267,
7043,
31160,
428,
1023,
478,
980,
428,
322,
11313,
460,
1546,
4854,
15151,
428,
15023,
323,
34522,
2363,
428,
37822,
1279,
428,
11835,
12406,
2454,
428,
39942,
27493,
2388,
31470,
19990,
428,
657,
297,
2996,
428,
380,
8801,
34689,
5174,
15195,
1497,
313,
41,
5964,
10,
556,
5728,
1491,
327,
849,
2223,
247,
861,
390,
19831,
6634,
275,
247,
1617,
15,
18770,
273,
436,
1491,
3249,
432,
2207,
15671,
292,
13,
247,
5284,
7520,
2728,
5447,
15,
380,
4294,
273,
247,
861,
390,
19831,
310,
3798,
7117,
347,
247,
7227,
6642,
273,
253,
7155,
273,
1363,
665,
452,
326,
4735,
15,
380,
4294,
778,
671,
320,
7117,
347,
247,
6919,
15,
380,
806,
1180,
273,
253,
6919,
310,
849,
1142,
952,
574,
253,
19831,
13,
285,
253,
1273,
1180,
310,
253,
2264,
1180,
273,
952,
665,
497,
6730,
275,
581,
1263,
15,
1198,
1650,
13,
247,
4294,
273,
2030,
16,
1099,
2097,
326,
275,
247,
1263,
273,
2030,
952,
512,
1363,
497,
1119,
281,
452,
326,
19831,
15,
4923,
841,
11383,
403,
1754,
327,
247,
2173,
1263,
13,
253,
17711,
778,
320,
1027,
604,
1529,
1387,
273,
1363,
403,
6730,
15,
13168,
13,
642,
1491,
327,
4294,
310,
2130,
15,
496,
841,
2219,
13,
253,
861,
390,
19831,
778,
320,
7520,
390,
1846,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
403,
253,
5917,
273,
17486,
350,
9237,
3736,
1276,
403,
253,
7871,
285,
5917,
273,
17486,
350,
9237,
32,
380,
7871,
285,
5917,
2330,
342,
17486,
350,
9237,
476,
6889,
7293,
327,
253,
830,
273,
17486,
350,
9237,
271,
5876,
2060,
556,
15,
380,
1331,
257,
3165,
4948,
313,
2043,
920,
1078,
4201,
10,
476,
320,
1495,
14,
33897,
13,
1223,
253,
8946,
830,
13,
5068,
275,
2393,
11948,
13,
14280,
281,
320,
1679,
5460,
15,
380,
1331,
257,
3165,
4948,
273,
17486,
350,
9237,
313,
10706,
309,
13,
3719,
285,
8019,
10,
778,
806,
320,
7943,
407,
32459,
595,
1029,
2308,
273,
717,
8311,
3875,
6514,
8704,
253,
5876,
36866,
313,
18372,
22034,
3358,
79,
3783,
558,
20346,
6742,
28,
285,
6830,
1495,
14,
33897,
7043,
313,
84,
26796,
14,
19700,
504,
10,
2957,
15,
329,
21494,
48842,
778,
452,
15198,
13,
33510,
13,
30709,
13,
4433,
281,
34298,
13,
13444,
3116,
13,
12720,
12564,
13,
285,
16,
263,
21488,
17754,
3386,
313,
12512,
12406,
2454,
13,
11906,
22977,
13,
1781,
2927,
13,
26322,
27951,
13628,
13,
285,
3926,
18225,
6208,
481,
40788,
342,
1511,
8019,
778,
671,
452,
8468,
460,
1546,
26057,
1255,
313,
31629,
2957,
4269,
407,
19147,
275,
253,
6703,
2472,
481,
38237,
17486,
350,
9237,
5431,
4916,
5165,
275,
42986,
285,
310,
7943,
407,
4433,
281,
34298,
285,
1030,
32713,
275,
253,
806,
807,
273,
1495,
15,
40561,
3056,
778,
2486,
7043,
45671,
13,
18693,
13,
6616,
14855,
13,
3116,
5778,
285,
16743,
5778,
15,
28622,
273,
6714,
11914,
21437,
949,
253,
16327,
476,
1421,
281,
45115,
13,
1030,
32713,
13,
285,
2559,
16327,
3275,
313,
18372,
21576,
481,
28622,
273,
6714,
11672,
949,
253,
16327,
313,
27049,
1179,
5297,
21576,
10,
476,
2847,
49060,
273,
253,
14910,
313,
35279,
32889,
481,
2091,
436,
6714,
11672,
4916,
17063,
275,
253,
33193,
13,
4408,
275,
253,
33193,
476,
2489,
43656,
313,
570,
545,
29536,
5620,
2433,
481,
11578,
2308,
273,
23160,
275,
253,
2614,
313,
35040,
536,
267,
9512,
10,
2847,
253,
6616,
14855,
13,
1531,
42956,
13,
285,
18693,
275,
5876,
4292,
15,
380,
8801,
34689,
5174,
15195,
1497,
3400,
253,
1563,
1618,
273,
7871,
285,
5917,
323,
17486,
350,
9237,
15,
1310,
253,
1491,
310,
2130,
13,
253,
2829,
2708,
3797,
849,
2223,
253,
19831,
310,
2326,
275,
952,
342,
436,
1617,
15,
1422,
476,
897,
253,
3050,
1282,
25263,
8710,
26372,
281,
1007,
598,
253,
14308,
323,
841,
3739,
2426,
15,
8714,
84,
285,
40561,
3056,
17274,
13954,
1180,
273,
1363,
313,
9453,
2130,
10,
3506,
6320,
10919,
32337,
5091,
6,
3506,
12850,
1319,
273,
11082,
16,
9511,
493,
4914,
5091,
6,
14196,
45540,
5091,
6,
25295,
3100,
5297,
21576,
818,
15,
22,
6,
25295,
297,
1530,
265,
9512,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
30811,
1238,
428,
3506,
12850,
1319,
273,
253,
22043,
35244,
1177,
428,
3506,
12850,
1319,
273,
253,
256,
498,
3525,
428,
5271,
13304,
24096,
422,
24954,
428,
775,
857,
29536,
5620,
2433,
428,
4731,
257,
1562,
11653,
428,
14869,
32713,
428,
44398,
833,
41418,
24077,
2281,
428,
1605,
37249,
428,
6129,
28487,
428,
3619,
8895,
428,
32104,
281,
34298,
428,
401,
16190,
3488,
21576,
428,
401,
972,
428,
1879,
8226,
12145,
272,
428,
4214,
1025,
6616,
14855,
428,
11841,
28516,
41575,
18320,
428,
49125,
10553,
428,
26992,
793,
16728,
261,
428,
25411,
4507,
3816,
249,
14,
606,
33721,
985,
428,
25411,
8950,
7337,
251,
1204,
428,
25411,
1179,
5297,
21576,
428,
25411,
19700,
301,
5650,
428,
25411,
25781,
363,
21576,
428,
25411,
856,
296,
38324,
249,
21576,
428,
25295,
3770,
77,
4362,
571,
428,
25295,
536,
267,
9512,
428,
25295,
536,
267,
11060,
3500,
3770,
77,
4362,
280,
10761,
42008,
2433,
428,
25295,
536,
267,
11060,
10761,
42008,
2433,
428,
25295,
251,
255,
46739,
428,
25295,
410,
23210,
571,
428,
25295,
493,
864,
21576,
428,
25295,
302,
2452,
428,
16009,
12260,
21039,
20828,
428,
16009,
12260,
294,
47119,
273,
21437,
428,
32483,
19682,
3816,
249,
1268,
428,
32483,
6658,
46400,
249,
444,
19,
428,
32483,
19006,
23160,
428,
17545,
37246,
12564,
428,
21157,
2927,
428,
11578,
14,
936,
14,
6320,
2614,
3473,
428,
5602,
287,
336,
545,
5242,
428,
5602,
8601,
571,
428,
18521,
5778,
428,
4878,
2148,
1531,
11441,
428,
4878,
2772,
37251,
9409,
428,
3532,
545,
29536,
5620,
2433,
428,
49000,
32889,
428,
367,
4885,
19257,
428,
3130,
10120,
2824,
571,
428,
18371,
22034,
3358,
79,
3783,
428,
18371,
21576,
428,
13343,
1177,
4201,
428,
13798,
14622,
22977,
428,
4410,
5504,
10919,
26505,
14944,
46909,
9827,
428,
12751,
267,
39975,
428,
12751,
267,
47806,
356,
77,
8056,
792,
894,
37416,
16,
27049,
24506,
428,
12751,
267,
23160,
31160,
428,
12751,
267,
7043,
31160,
428,
1023,
478,
980,
428,
322,
11313,
460,
1546,
4854,
15151,
428,
15023,
323,
34522,
2363,
428,
37822,
1279,
428,
11835,
12406,
2454,
428,
39942,
27493,
2388,
31470,
19990,
428,
657,
297,
2996,
428,
380,
8801,
34689,
5174,
15195,
1497,
313,
41,
5964,
10,
556,
5728,
1491,
327,
849,
2223,
247,
861,
390,
19831,
6634,
275,
247,
1617,
15,
18770,
273,
436,
1491,
3249,
432,
2207,
15671,
292,
13,
247,
5284,
7520,
2728,
5447,
15,
380,
4294,
273,
247,
861,
390,
19831,
310,
3798,
7117,
347,
247,
7227,
6642,
273,
253,
7155,
273,
1363,
665,
452,
326,
4735,
15,
380,
4294,
778,
671,
320,
7117,
347,
247,
6919,
15,
380,
806,
1180,
273,
253,
6919,
310,
849,
1142,
952,
574,
253,
19831,
13,
285,
253,
1273,
1180,
310,
253,
2264,
1180,
273,
952,
665,
497,
6730,
275,
581,
1263,
15,
1198,
1650,
13,
247,
4294,
273,
2030,
16,
1099,
2097,
326,
275,
247,
1263,
273,
2030,
952,
512,
1363,
497,
1119,
281,
452,
326,
19831,
15,
4923,
841,
11383,
403,
1754,
327,
247,
2173,
1263,
13,
253,
17711,
778,
320,
1027,
604,
1529,
1387,
273,
1363,
403,
6730,
15,
13168,
13,
642,
1491,
327,
4294,
310,
2130,
15,
496,
841,
2219,
13,
253,
861,
390,
19831,
778,
320,
7520,
390,
1846,
15
] |
What is (are) giant axonal neuropathy ? | Giant axonal neuropathy is an inherited condition involving dysfunction of a specific type of protein in nerve cells (neurons). The protein is essential for normal nerve function because it forms neurofilaments. Neurofilaments make up a structural framework that helps to define the shape and size of the neurons. This condition is characterized by abnormally large and dysfunctional axons, which are the specialized extensions of nerve cells that are required for the transmission of nerve impulses. Giant axonal neuropathy generally appears in infancy or early childhood. It progresses slowly as neuronal injury becomes more severe. Signs of giant axonal neuropathy usually begin in the peripheral nervous system, which governs movement and sensation in the arms, legs, and other parts of the body. Most individuals with this disorder first have problems with walking. Later they may lose sensation, coordination, strength, and reflexes in their limbs. Hearing and visual problems may also occur. Extremely kinky hair (as compared to others in the family) is characteristic of giant axonal neuropathy, occurring in almost all affected people. As the disorder progresses, the brain and spinal cord (central nervous system) may become involved, causing a gradual decline in mental function, loss of control of body movement, and seizures. | [
1276,
310,
313,
609,
10,
10864,
45338,
44268,
3736,
40,
6231,
45338,
44268,
310,
271,
20265,
1617,
7668,
12909,
273,
247,
2173,
1511,
273,
2601,
275,
11083,
1341,
313,
32167,
790,
481,
380,
2601,
310,
5667,
323,
2622,
11083,
1159,
984,
352,
4948,
6551,
5073,
19491,
15,
22054,
5073,
19491,
1056,
598,
247,
8350,
7792,
326,
7729,
281,
4853,
253,
5281,
285,
1979,
273,
253,
8512,
15,
831,
1617,
310,
7943,
407,
32459,
595,
1781,
285,
12909,
267,
41382,
13,
534,
403,
253,
18052,
18149,
273,
11083,
1341,
326,
403,
2424,
323,
253,
6322,
273,
11083,
48009,
15,
50276,
40,
6231,
45338,
44268,
3839,
4620,
275,
42986,
390,
2393,
11948,
15,
733,
42851,
7808,
347,
16069,
4975,
4916,
625,
5460,
15,
8714,
84,
273,
10864,
45338,
44268,
3798,
3135,
275,
253,
10844,
11219,
985,
13,
534,
42086,
4866,
285,
22135,
275,
253,
6174,
13,
9246,
13,
285,
643,
4243,
273,
253,
2133,
15,
5595,
4292,
342,
436,
8984,
806,
452,
3237,
342,
7824,
15,
14772,
597,
778,
7168,
22135,
13,
19915,
13,
4757,
13,
285,
22375,
265,
275,
616,
24601,
15,
38308,
285,
5304,
3237,
778,
671,
2826,
15,
9052,
42807,
465,
46279,
4707,
313,
284,
2429,
281,
2571,
275,
253,
2021,
10,
310,
8847,
273,
10864,
45338,
44268,
13,
12952,
275,
2761,
512,
5876,
952,
15,
50276,
1909,
253,
8984,
42851,
13,
253,
3998,
285,
14472,
12045,
313,
25765,
11219,
985,
10,
778,
2489,
3206,
13,
8479,
247,
26830,
10343,
275,
6255,
1159,
13,
2957,
273,
1453,
273,
2133,
4866,
13,
285,
26347,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
310,
313,
609,
10,
10864,
45338,
44268,
3736,
40,
6231,
45338,
44268,
310,
271,
20265,
1617,
7668,
12909,
273,
247,
2173,
1511,
273,
2601,
275,
11083,
1341,
313,
32167,
790,
481,
380,
2601,
310,
5667,
323,
2622,
11083,
1159,
984,
352,
4948,
6551,
5073,
19491,
15,
22054,
5073,
19491,
1056,
598,
247,
8350,
7792,
326,
7729,
281,
4853,
253,
5281,
285,
1979,
273,
253,
8512,
15,
831,
1617,
310,
7943,
407,
32459,
595,
1781,
285,
12909,
267,
41382,
13,
534,
403,
253,
18052,
18149,
273,
11083,
1341,
326,
403,
2424,
323,
253,
6322,
273,
11083,
48009,
15,
50276,
40,
6231,
45338,
44268,
3839,
4620,
275,
42986,
390,
2393,
11948,
15,
733,
42851,
7808,
347,
16069,
4975,
4916,
625,
5460,
15,
8714,
84,
273,
10864,
45338,
44268,
3798,
3135,
275,
253,
10844,
11219,
985,
13,
534,
42086,
4866,
285,
22135,
275,
253,
6174,
13,
9246,
13,
285,
643,
4243,
273,
253,
2133,
15,
5595,
4292,
342,
436,
8984,
806,
452,
3237,
342,
7824,
15,
14772,
597,
778,
7168,
22135,
13,
19915,
13,
4757,
13,
285,
22375,
265,
275,
616,
24601,
15,
38308,
285,
5304,
3237,
778,
671,
2826,
15,
9052,
42807,
465,
46279,
4707,
313,
284,
2429,
281,
2571,
275,
253,
2021,
10,
310,
8847,
273,
10864,
45338,
44268,
13,
12952,
275,
2761,
512,
5876,
952,
15,
50276,
1909,
253,
8984,
42851,
13,
253,
3998,
285,
14472,
12045,
313,
25765,
11219,
985,
10,
778,
2489,
3206,
13,
8479,
247,
26830,
10343,
275,
6255,
1159,
13,
2957,
273,
1453,
273,
2133,
4866,
13,
285,
26347,
15
] |
What is the outlook for Childhood Soft Tissue Sarcoma ? | Certain factors affect prognosis (chance of recovery) and treatment options. The prognosis (chance of recovery) and treatment options depend on the following: - The part of the body where the tumor first formed. - The size and grade of the tumor. - The type of soft tissue sarcoma. - How deep the tumor is under the skin. - Whether the tumor has spread to other places in the body. - The amount of tumor remaining after surgery to remove it. - Whether radiation therapy was used to treat the tumor. - The age and gender of the patient. - Whether the cancer has just been diagnosed or has recurred (come back). | [
1276,
310,
253,
29338,
323,
8347,
3639,
31307,
39218,
9997,
18187,
3736,
36,
1695,
2616,
2818,
17102,
313,
348,
593,
273,
7355,
10,
285,
1971,
4610,
15,
380,
17102,
313,
348,
593,
273,
7355,
10,
285,
1971,
4610,
3469,
327,
253,
1563,
27,
50269,
14,
380,
629,
273,
253,
2133,
835,
253,
4502,
806,
4447,
15,
50274,
14,
380,
1979,
285,
9646,
273,
253,
4502,
15,
50274,
14,
380,
1511,
273,
2602,
4408,
45928,
15,
50274,
14,
1359,
3676,
253,
4502,
310,
762,
253,
4808,
15,
50274,
14,
12369,
253,
4502,
556,
5195,
281,
643,
5053,
275,
253,
2133,
15,
50274,
14,
380,
2408,
273,
4502,
5780,
846,
5869,
281,
5386,
352,
15,
50274,
14,
12369,
7742,
4918,
369,
908,
281,
1555,
253,
4502,
15,
50274,
14,
380,
2363,
285,
8645,
273,
253,
3110,
15,
50274,
14,
12369,
253,
2923,
556,
816,
644,
11245,
390,
556,
11896,
433,
313,
3188,
896,
481
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
310,
253,
29338,
323,
8347,
3639,
31307,
39218,
9997,
18187,
3736,
36,
1695,
2616,
2818,
17102,
313,
348,
593,
273,
7355,
10,
285,
1971,
4610,
15,
380,
17102,
313,
348,
593,
273,
7355,
10,
285,
1971,
4610,
3469,
327,
253,
1563,
27,
50269,
14,
380,
629,
273,
253,
2133,
835,
253,
4502,
806,
4447,
15,
50274,
14,
380,
1979,
285,
9646,
273,
253,
4502,
15,
50274,
14,
380,
1511,
273,
2602,
4408,
45928,
15,
50274,
14,
1359,
3676,
253,
4502,
310,
762,
253,
4808,
15,
50274,
14,
12369,
253,
4502,
556,
5195,
281,
643,
5053,
275,
253,
2133,
15,
50274,
14,
380,
2408,
273,
4502,
5780,
846,
5869,
281,
5386,
352,
15,
50274,
14,
12369,
7742,
4918,
369,
908,
281,
1555,
253,
4502,
15,
50274,
14,
380,
2363,
285,
8645,
273,
253,
3110,
15,
50274,
14,
12369,
253,
2923,
556,
816,
644,
11245,
390,
556,
11896,
433,
313,
3188,
896,
481
] |
What are the symptoms of Dihydropteridine reductase deficiency ? | What are the signs and symptoms of Dihydropteridine reductase deficiency? The Human Phenotype Ontology provides the following list of signs and symptoms for Dihydropteridine reductase deficiency. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Cognitive impairment 90% Microcephaly 90% Autosomal recessive inheritance - Cerebral calcification - Choreoathetosis - Dysphagia - Dystonia - Episodic fever - Excessive salivation - Hyperphenylalaninemia - Hypertonia - Infantile onset - Intellectual disability - Irritability - Muscular hypotonia - Myoclonus - Progressive neurologic deterioration - Seizures - Tremor - Variable expressivity - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common. | [
1276,
403,
253,
5917,
273,
6129,
1994,
12233,
350,
13196,
39853,
14384,
3736,
1276,
403,
253,
7871,
285,
5917,
273,
6129,
1994,
12233,
350,
13196,
39853,
14384,
32,
380,
8801,
34689,
5174,
15195,
1497,
3400,
253,
1563,
1618,
273,
7871,
285,
5917,
323,
6129,
1994,
12233,
350,
13196,
39853,
14384,
15,
1310,
253,
1491,
310,
2130,
13,
253,
2829,
2708,
3797,
849,
2223,
253,
19831,
310,
2326,
275,
952,
342,
436,
1617,
15,
1422,
476,
897,
253,
3050,
1282,
25263,
8710,
26372,
281,
1007,
598,
253,
14308,
323,
841,
3739,
2426,
15,
8714,
84,
285,
40561,
3056,
17274,
13954,
1180,
273,
1363,
313,
9453,
2130,
10,
43419,
15151,
5091,
6,
12761,
336,
545,
5242,
5091,
6,
5271,
13304,
24096,
422,
24954,
428,
330,
11892,
11887,
9039,
1877,
428,
775,
410,
80,
4349,
85,
2433,
428,
399,
656,
545,
356,
571,
428,
31787,
5493,
571,
428,
10643,
261,
23329,
15198,
428,
1889,
49492,
3779,
7639,
428,
25411,
22451,
30637,
249,
9512,
428,
25411,
1299,
571,
428,
13160,
386,
587,
11653,
428,
17545,
37246,
12564,
428,
7854,
902,
1430,
428,
4878,
2772,
37251,
9409,
428,
2752,
15436,
251,
316,
428,
39935,
15674,
280,
28153,
428,
1023,
478,
980,
428,
308,
2013,
263,
428,
34725,
3890,
2351,
428,
380,
8801,
34689,
5174,
15195,
1497,
313,
41,
5964,
10,
556,
5728,
1491,
327,
849,
2223,
247,
861,
390,
19831,
6634,
275,
247,
1617,
15,
18770,
273,
436,
1491,
3249,
432,
2207,
15671,
292,
13,
247,
5284,
7520,
2728,
5447,
15,
380,
4294,
273,
247,
861,
390,
19831,
310,
3798,
7117,
347,
247,
7227,
6642,
273,
253,
7155,
273,
1363,
665,
452,
326,
4735,
15,
380,
4294,
778,
671,
320,
7117,
347,
247,
6919,
15,
380,
806,
1180,
273,
253,
6919,
310,
849,
1142,
952,
574,
253,
19831,
13,
285,
253,
1273,
1180,
310,
253,
2264,
1180,
273,
952,
665,
497,
6730,
275,
581,
1263,
15,
1198,
1650,
13,
247,
4294,
273,
2030,
16,
1099,
2097,
326,
275,
247,
1263,
273,
2030,
952,
512,
1363,
497,
1119,
281,
452,
326,
19831,
15,
4923,
841,
11383,
403,
1754,
327,
247,
2173,
1263,
13,
253,
17711,
778,
320,
1027,
604,
1529,
1387,
273,
1363,
403,
6730,
15,
13168,
13,
642,
1491,
327,
4294,
310,
2130,
15,
496,
841,
2219,
13,
253,
861,
390,
19831,
778,
320,
7520,
390,
1846,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
403,
253,
5917,
273,
6129,
1994,
12233,
350,
13196,
39853,
14384,
3736,
1276,
403,
253,
7871,
285,
5917,
273,
6129,
1994,
12233,
350,
13196,
39853,
14384,
32,
380,
8801,
34689,
5174,
15195,
1497,
3400,
253,
1563,
1618,
273,
7871,
285,
5917,
323,
6129,
1994,
12233,
350,
13196,
39853,
14384,
15,
1310,
253,
1491,
310,
2130,
13,
253,
2829,
2708,
3797,
849,
2223,
253,
19831,
310,
2326,
275,
952,
342,
436,
1617,
15,
1422,
476,
897,
253,
3050,
1282,
25263,
8710,
26372,
281,
1007,
598,
253,
14308,
323,
841,
3739,
2426,
15,
8714,
84,
285,
40561,
3056,
17274,
13954,
1180,
273,
1363,
313,
9453,
2130,
10,
43419,
15151,
5091,
6,
12761,
336,
545,
5242,
5091,
6,
5271,
13304,
24096,
422,
24954,
428,
330,
11892,
11887,
9039,
1877,
428,
775,
410,
80,
4349,
85,
2433,
428,
399,
656,
545,
356,
571,
428,
31787,
5493,
571,
428,
10643,
261,
23329,
15198,
428,
1889,
49492,
3779,
7639,
428,
25411,
22451,
30637,
249,
9512,
428,
25411,
1299,
571,
428,
13160,
386,
587,
11653,
428,
17545,
37246,
12564,
428,
7854,
902,
1430,
428,
4878,
2772,
37251,
9409,
428,
2752,
15436,
251,
316,
428,
39935,
15674,
280,
28153,
428,
1023,
478,
980,
428,
308,
2013,
263,
428,
34725,
3890,
2351,
428,
380,
8801,
34689,
5174,
15195,
1497,
313,
41,
5964,
10,
556,
5728,
1491,
327,
849,
2223,
247,
861,
390,
19831,
6634,
275,
247,
1617,
15,
18770,
273,
436,
1491,
3249,
432,
2207,
15671,
292,
13,
247,
5284,
7520,
2728,
5447,
15,
380,
4294,
273,
247,
861,
390,
19831,
310,
3798,
7117,
347,
247,
7227,
6642,
273,
253,
7155,
273,
1363,
665,
452,
326,
4735,
15,
380,
4294,
778,
671,
320,
7117,
347,
247,
6919,
15,
380,
806,
1180,
273,
253,
6919,
310,
849,
1142,
952,
574,
253,
19831,
13,
285,
253,
1273,
1180,
310,
253,
2264,
1180,
273,
952,
665,
497,
6730,
275,
581,
1263,
15,
1198,
1650,
13,
247,
4294,
273,
2030,
16,
1099,
2097,
326,
275,
247,
1263,
273,
2030,
952,
512,
1363,
497,
1119,
281,
452,
326,
19831,
15,
4923,
841,
11383,
403,
1754,
327,
247,
2173,
1263,
13,
253,
17711,
778,
320,
1027,
604,
1529,
1387,
273,
1363,
403,
6730,
15,
13168,
13,
642,
1491,
327,
4294,
310,
2130,
15,
496,
841,
2219,
13,
253,
861,
390,
19831,
778,
320,
7520,
390,
1846,
15
] |
What are the symptoms of Refsum disease, infantile form ? | What are the signs and symptoms of Refsum disease, infantile form? The Human Phenotype Ontology provides the following list of signs and symptoms for Refsum disease, infantile form. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Abnormality of metabolism/homeostasis 90% Abnormality of retinal pigmentation 90% Cognitive impairment 90% Hepatomegaly 90% Nyctalopia 90% Short stature 90% Skeletal muscle atrophy 90% Visual impairment 90% Behavioral abnormality 50% Hypertonia 50% Incoordination 50% Muscular hypotonia 50% Nystagmus 50% Sensorineural hearing impairment 50% Abnormality of epiphysis morphology 7.5% Arrhythmia 7.5% Cataract 7.5% Facial palsy 7.5% Hypertrophic cardiomyopathy 7.5% Ichthyosis 7.5% Optic atrophy 7.5% Seizures 7.5% Abnormal bleeding - Abnormal electroretinogram - Abnormal facial shape - Autosomal recessive inheritance - Congenital onset - Depressed nasal ridge - Failure to thrive - Flat face - Hypocholesterolemia - Hyporeflexia - Intellectual disability - Malar flattening - Osteoporosis - Polyneuropathy - Rod-cone dystrophy - Single transverse palmar crease - Steatorrhea - Very long chain fatty acid accumulation - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common. | [
1276,
403,
253,
5917,
273,
7567,
2204,
2728,
13,
13131,
587,
830,
3736,
1276,
403,
253,
7871,
285,
5917,
273,
7567,
2204,
2728,
13,
13131,
587,
830,
32,
380,
8801,
34689,
5174,
15195,
1497,
3400,
253,
1563,
1618,
273,
7871,
285,
5917,
323,
7567,
2204,
2728,
13,
13131,
587,
830,
15,
1310,
253,
1491,
310,
2130,
13,
253,
2829,
2708,
3797,
849,
2223,
253,
19831,
310,
2326,
275,
952,
342,
436,
1617,
15,
1422,
476,
897,
253,
3050,
1282,
25263,
8710,
26372,
281,
1007,
598,
253,
14308,
323,
841,
3739,
2426,
15,
8714,
84,
285,
40561,
3056,
17274,
13954,
1180,
273,
1363,
313,
9453,
2130,
10,
3506,
12850,
1319,
273,
11082,
16,
9511,
493,
4914,
5091,
6,
3506,
12850,
1319,
273,
22043,
8393,
16977,
5091,
6,
43419,
15151,
5091,
6,
21709,
255,
485,
72,
5242,
5091,
6,
34154,
291,
267,
30147,
5091,
6,
14196,
45540,
5091,
6,
322,
30554,
6616,
34512,
5091,
6,
17633,
15151,
5091,
6,
29475,
267,
43108,
2456,
6,
25411,
1299,
571,
2456,
6,
496,
29309,
1515,
2456,
6,
4878,
2772,
37251,
9409,
2456,
6,
427,
9207,
356,
14557,
2456,
6,
322,
11313,
460,
1546,
4854,
15151,
2456,
6,
3506,
12850,
1319,
273,
2563,
16372,
1493,
15448,
818,
15,
22,
6,
1780,
83,
14292,
571,
818,
15,
22,
6,
12441,
274,
514,
818,
15,
22,
6,
16035,
451,
39839,
90,
818,
15,
22,
6,
8305,
8292,
16117,
50098,
818,
15,
22,
6,
32185,
24085,
2433,
818,
15,
22,
6,
12551,
280,
34512,
818,
15,
22,
6,
1023,
478,
980,
818,
15,
22,
6,
3506,
6320,
14771,
428,
3506,
6320,
4640,
1221,
249,
12935,
428,
3506,
6320,
17754,
5281,
428,
5271,
13304,
24096,
422,
24954,
428,
4731,
257,
1562,
11653,
428,
3315,
2079,
23761,
27563,
428,
32104,
281,
34298,
428,
36682,
2454,
428,
25295,
3770,
11201,
1306,
15604,
428,
25295,
410,
23210,
571,
428,
17545,
37246,
12564,
428,
5979,
274,
30627,
2980,
428,
49000,
29606,
2433,
428,
18371,
570,
8177,
7822,
428,
11064,
14,
37184,
32692,
13354,
428,
19757,
17430,
5796,
4175,
1424,
511,
428,
2951,
1080,
83,
21071,
428,
15997,
1048,
5931,
14126,
3527,
12037,
428,
380,
8801,
34689,
5174,
15195,
1497,
313,
41,
5964,
10,
556,
5728,
1491,
327,
849,
2223,
247,
861,
390,
19831,
6634,
275,
247,
1617,
15,
18770,
273,
436,
1491,
3249,
432,
2207,
15671,
292,
13,
247,
5284,
7520,
2728,
5447,
15,
380,
4294,
273,
247,
861,
390,
19831,
310,
3798,
7117,
347,
247,
7227,
6642,
273,
253,
7155,
273,
1363,
665,
452,
326,
4735,
15,
380,
4294,
778,
671,
320,
7117,
347,
247,
6919,
15,
380,
806,
1180,
273,
253,
6919,
310,
849,
1142,
952,
574,
253,
19831,
13,
285,
253,
1273,
1180,
310,
253,
2264,
1180,
273,
952,
665,
497,
6730,
275,
581,
1263,
15,
1198,
1650,
13,
247,
4294,
273,
2030,
16,
1099,
2097,
326,
275,
247,
1263,
273,
2030,
952,
512,
1363,
497,
1119,
281,
452,
326,
19831,
15,
4923,
841,
11383,
403,
1754,
327,
247,
2173,
1263,
13,
253,
17711,
778,
320,
1027,
604,
1529,
1387,
273,
1363,
403,
6730,
15,
13168,
13,
642,
1491,
327,
4294,
310,
2130,
15,
496,
841,
2219,
13,
253,
861,
390,
19831,
778,
320,
7520,
390,
1846,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
403,
253,
5917,
273,
7567,
2204,
2728,
13,
13131,
587,
830,
3736,
1276,
403,
253,
7871,
285,
5917,
273,
7567,
2204,
2728,
13,
13131,
587,
830,
32,
380,
8801,
34689,
5174,
15195,
1497,
3400,
253,
1563,
1618,
273,
7871,
285,
5917,
323,
7567,
2204,
2728,
13,
13131,
587,
830,
15,
1310,
253,
1491,
310,
2130,
13,
253,
2829,
2708,
3797,
849,
2223,
253,
19831,
310,
2326,
275,
952,
342,
436,
1617,
15,
1422,
476,
897,
253,
3050,
1282,
25263,
8710,
26372,
281,
1007,
598,
253,
14308,
323,
841,
3739,
2426,
15,
8714,
84,
285,
40561,
3056,
17274,
13954,
1180,
273,
1363,
313,
9453,
2130,
10,
3506,
12850,
1319,
273,
11082,
16,
9511,
493,
4914,
5091,
6,
3506,
12850,
1319,
273,
22043,
8393,
16977,
5091,
6,
43419,
15151,
5091,
6,
21709,
255,
485,
72,
5242,
5091,
6,
34154,
291,
267,
30147,
5091,
6,
14196,
45540,
5091,
6,
322,
30554,
6616,
34512,
5091,
6,
17633,
15151,
5091,
6,
29475,
267,
43108,
2456,
6,
25411,
1299,
571,
2456,
6,
496,
29309,
1515,
2456,
6,
4878,
2772,
37251,
9409,
2456,
6,
427,
9207,
356,
14557,
2456,
6,
322,
11313,
460,
1546,
4854,
15151,
2456,
6,
3506,
12850,
1319,
273,
2563,
16372,
1493,
15448,
818,
15,
22,
6,
1780,
83,
14292,
571,
818,
15,
22,
6,
12441,
274,
514,
818,
15,
22,
6,
16035,
451,
39839,
90,
818,
15,
22,
6,
8305,
8292,
16117,
50098,
818,
15,
22,
6,
32185,
24085,
2433,
818,
15,
22,
6,
12551,
280,
34512,
818,
15,
22,
6,
1023,
478,
980,
818,
15,
22,
6,
3506,
6320,
14771,
428,
3506,
6320,
4640,
1221,
249,
12935,
428,
3506,
6320,
17754,
5281,
428,
5271,
13304,
24096,
422,
24954,
428,
4731,
257,
1562,
11653,
428,
3315,
2079,
23761,
27563,
428,
32104,
281,
34298,
428,
36682,
2454,
428,
25295,
3770,
11201,
1306,
15604,
428,
25295,
410,
23210,
571,
428,
17545,
37246,
12564,
428,
5979,
274,
30627,
2980,
428,
49000,
29606,
2433,
428,
18371,
570,
8177,
7822,
428,
11064,
14,
37184,
32692,
13354,
428,
19757,
17430,
5796,
4175,
1424,
511,
428,
2951,
1080,
83,
21071,
428,
15997,
1048,
5931,
14126,
3527,
12037,
428,
380,
8801,
34689,
5174,
15195,
1497,
313,
41,
5964,
10,
556,
5728,
1491,
327,
849,
2223,
247,
861,
390,
19831,
6634,
275,
247,
1617,
15,
18770,
273,
436,
1491,
3249,
432,
2207,
15671,
292,
13,
247,
5284,
7520,
2728,
5447,
15,
380,
4294,
273,
247,
861,
390,
19831,
310,
3798,
7117,
347,
247,
7227,
6642,
273,
253,
7155,
273,
1363,
665,
452,
326,
4735,
15,
380,
4294,
778,
671,
320,
7117,
347,
247,
6919,
15,
380,
806,
1180,
273,
253,
6919,
310,
849,
1142,
952,
574,
253,
19831,
13,
285,
253,
1273,
1180,
310,
253,
2264,
1180,
273,
952,
665,
497,
6730,
275,
581,
1263,
15,
1198,
1650,
13,
247,
4294,
273,
2030,
16,
1099,
2097,
326,
275,
247,
1263,
273,
2030,
952,
512,
1363,
497,
1119,
281,
452,
326,
19831,
15,
4923,
841,
11383,
403,
1754,
327,
247,
2173,
1263,
13,
253,
17711,
778,
320,
1027,
604,
1529,
1387,
273,
1363,
403,
6730,
15,
13168,
13,
642,
1491,
327,
4294,
310,
2130,
15,
496,
841,
2219,
13,
253,
861,
390,
19831,
778,
320,
7520,
390,
1846,
15
] |
Is erythromelalgia inherited ? | Some cases of erythromelalgia occur in an autosomal dominant pattern, which means one copy of the altered gene in each cell is sufficient to cause the disorder. In some of these instances, an affected person inherits the mutation from one affected parent. Other cases result from new mutations in the gene and occur in people with no history of the disorder in their family. | [
2513,
21564,
409,
293,
32836,
20265,
3736,
6080,
2219,
273,
21564,
409,
293,
32836,
2826,
275,
271,
48981,
11360,
3102,
13,
534,
2097,
581,
3491,
273,
253,
12059,
3320,
275,
1016,
894,
310,
4209,
281,
2847,
253,
8984,
15,
496,
690,
273,
841,
10872,
13,
271,
5876,
1436,
10958,
953,
253,
10577,
432,
581,
5876,
2885,
15,
5131,
2219,
906,
432,
747,
9197,
275,
253,
3320,
285,
2826,
275,
952,
342,
642,
2892,
273,
253,
8984,
275,
616,
2021,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
2513,
21564,
409,
293,
32836,
20265,
3736,
6080,
2219,
273,
21564,
409,
293,
32836,
2826,
275,
271,
48981,
11360,
3102,
13,
534,
2097,
581,
3491,
273,
253,
12059,
3320,
275,
1016,
894,
310,
4209,
281,
2847,
253,
8984,
15,
496,
690,
273,
841,
10872,
13,
271,
5876,
1436,
10958,
953,
253,
10577,
432,
581,
5876,
2885,
15,
5131,
2219,
906,
432,
747,
9197,
275,
253,
3320,
285,
2826,
275,
952,
342,
642,
2892,
273,
253,
8984,
275,
616,
2021,
15
] |
What is (are) Stroke ? | Stroke -- A Serious Event A stroke is serious, just like a heart attack. Each year in the United States, approximately 795,000 people have a stroke. About 610,000 of these are first or new strokes. On average, one American dies from stroke every four minutes. Stroke is the fourth leading cause of death in the United States, and causes more serious long-term disabilities than any other disease. Nearly three-quarters of all strokes occur in people over the age of 65. And the risk of having a stroke more than doubles each decade between the ages of 55 and 85. Stroke occurs in all age groups, in both sexes, and in all races in every country. It can even occur before birth, when the fetus is still in the womb. Learning about stroke can help you act in time to save a relative, neighbor, or friend. And making changes in your lifestyle can help you prevent stroke. What Is Stroke? A stroke is sometimes called a "brain attack." Most often, stroke occurs when blood flow to the brain stops because it is blocked by a clot. When this happens, the brain cells in the immediate area begin to die. Some brain cells die because they stop getting the oxygen and nutrients they need to function. Other brain cells die because they are damaged by sudden bleeding into or around the brain. The brain cells that don't die immediately remain at risk for death. These cells can linger in a compromised or weakened state for several hours. With timely treatment, these cells can be saved. New treatments are available that greatly reduce the damage caused by a stroke. But you need to arrive at the hospital as soon as possible after symptoms start to prevent disability and to greatly improve your chances for recovery. Knowing stroke symptoms, calling 911 immediately, and getting to a hospital as quickly as possible are critical. Ischemic Stroke There are two kinds of stroke. The most common kind of stroke is called ischemic stroke. It accounts for approximately 80 percent of all strokes. An ischemic stroke is caused by a blood clot that blocks or plugs a blood vessel supplying blood to the brain. Blockages that cause ischemic strokes stem from three conditions: - the formation of a clot within a blood vessel of the brain or neck, called thrombosis - the movement of a clot from another part of the body, such as from the heart to the neck or brain, called an embolism - a severe narrowing of an artery (stenosis) in or leading to the brain, due to fatty deposits lining the blood vessel walls. the formation of a clot within a blood vessel of the brain or neck, called thrombosis the movement of a clot from another part of the body, such as from the heart to the neck or brain, called an embolism a severe narrowing of an artery (stenosis) in or leading to the brain, due to fatty deposits lining the blood vessel walls. Hemorrhagic Stroke The other kind of stroke is called hemorrhagic stroke. A hemorrhagic stroke is caused by a blood vessel that breaks and bleeds into the brain. One common cause of a hemorrhagic stroke is a bleeding aneurysm. An aneurysm is a weak or thin spot on an artery wall. Over time, these weak spots stretch or balloon out due to high blood pressure. The thin walls of these ballooning aneurysms can rupture and spill blood into the space surrounding brain cells. Artery walls can also break open because they become encrusted, or covered with fatty deposits called plaque, eventually lose their elasticity and become brittle, thin, and prone to cracking. Hypertension, or high blood pressure, increases the risk that a brittle artery wall will give way and release blood into the surrounding brain tissue. | [
1276,
310,
313,
609,
10,
659,
7292,
3736,
998,
7292,
1969,
329,
4165,
784,
11846,
329,
9980,
310,
4092,
13,
816,
751,
247,
2798,
2983,
15,
5815,
807,
275,
253,
1986,
2077,
13,
5512,
818,
2222,
13,
933,
952,
452,
247,
9980,
15,
11376,
43385,
13,
933,
273,
841,
403,
806,
390,
747,
33518,
15,
1623,
3388,
13,
581,
2448,
9778,
432,
9980,
1046,
1740,
2909,
15,
659,
7292,
310,
253,
7002,
4283,
2847,
273,
2471,
275,
253,
1986,
2077,
13,
285,
5997,
625,
4092,
1048,
14,
3945,
26545,
685,
667,
643,
2728,
15,
36388,
1264,
14,
14105,
273,
512,
33518,
2826,
275,
952,
689,
253,
2363,
273,
7251,
15,
1244,
253,
2495,
273,
1907,
247,
9980,
625,
685,
33478,
1016,
9976,
875,
253,
11880,
273,
7288,
285,
9330,
15,
659,
7292,
6634,
275,
512,
2363,
2390,
13,
275,
1097,
35717,
13,
285,
275,
512,
15820,
275,
1046,
2586,
15,
733,
476,
1014,
2826,
1078,
4201,
13,
672,
253,
36866,
310,
1335,
275,
253,
49009,
15,
20727,
670,
9980,
476,
1361,
368,
769,
275,
673,
281,
5321,
247,
4103,
13,
6346,
13,
390,
3331,
15,
1244,
2403,
2544,
275,
634,
14898,
476,
1361,
368,
3657,
9980,
15,
1737,
1680,
659,
7292,
32,
329,
9980,
310,
4536,
1925,
247,
346,
21590,
2983,
449,
5595,
2223,
13,
9980,
6634,
672,
2614,
2685,
281,
253,
3998,
14545,
984,
352,
310,
13230,
407,
247,
31301,
15,
2091,
436,
6569,
13,
253,
3998,
1341,
275,
253,
8993,
2170,
3135,
281,
3150,
15,
3808,
3998,
1341,
3150,
984,
597,
3523,
2970,
253,
7768,
285,
23491,
597,
878,
281,
1159,
15,
5131,
3998,
1341,
3150,
984,
597,
403,
13572,
407,
5982,
14771,
715,
390,
1475,
253,
3998,
15,
380,
3998,
1341,
326,
1053,
626,
3150,
4745,
3464,
387,
2495,
323,
2471,
15,
2053,
1341,
476,
45001,
275,
247,
25047,
390,
33153,
1375,
323,
2067,
3038,
15,
2726,
14793,
1971,
13,
841,
1341,
476,
320,
9809,
15,
1457,
9694,
403,
2130,
326,
10260,
4796,
253,
4723,
4269,
407,
247,
9980,
15,
1292,
368,
878,
281,
12666,
387,
253,
4675,
347,
3517,
347,
1896,
846,
5917,
1265,
281,
3657,
12564,
285,
281,
10260,
3157,
634,
14512,
323,
7355,
15,
40828,
9980,
5917,
13,
6789,
28546,
4745,
13,
285,
2970,
281,
247,
4675,
347,
4541,
347,
1896,
403,
4619,
15,
309,
20645,
280,
659,
7292,
1707,
403,
767,
9351,
273,
9980,
15,
380,
954,
1846,
2238,
273,
9980,
310,
1925,
23523,
9980,
15,
733,
8553,
323,
5512,
5096,
2558,
273,
512,
33518,
15,
743,
23523,
9980,
310,
4269,
407,
247,
2614,
31301,
326,
8336,
390,
49359,
247,
2614,
11179,
28106,
2614,
281,
253,
3998,
15,
15204,
1131,
326,
2847,
23523,
33518,
8424,
432,
1264,
2515,
27,
428,
253,
4702,
273,
247,
31301,
1561,
247,
2614,
11179,
273,
253,
3998,
390,
7623,
13,
1925,
34029,
50276,
14,
253,
4866,
273,
247,
31301,
432,
1529,
629,
273,
253,
2133,
13,
824,
347,
432,
253,
2798,
281,
253,
7623,
390,
3998,
13,
1925,
271,
37165,
1204,
50276,
14,
247,
5460,
44746,
273,
271,
12235,
313,
16750,
2433,
10,
275,
390,
4283,
281,
253,
3998,
13,
1955,
281,
14126,
22413,
27535,
253,
2614,
11179,
8099,
15,
253,
4702,
273,
247,
31301,
1561,
247,
2614,
11179,
273,
253,
3998,
390,
7623,
13,
1925,
34029,
253,
4866,
273,
247,
31301,
432,
1529,
629,
273,
253,
2133,
13,
824,
347,
432,
253,
2798,
281,
253,
7623,
390,
3998,
13,
1925,
271,
37165,
1204,
247,
5460,
44746,
273,
271,
12235,
313,
16750,
2433,
10,
275,
390,
4283,
281,
253,
3998,
13,
1955,
281,
14126,
22413,
27535,
253,
2614,
11179,
8099,
15,
18402,
17536,
12795,
659,
7292,
380,
643,
2238,
273,
9980,
310,
1925,
21699,
12795,
9980,
15,
329,
21699,
12795,
9980,
310,
4269,
407,
247,
2614,
11179,
326,
13471,
285,
7387,
5797,
715,
253,
3998,
15,
2596,
1846,
2847,
273,
247,
21699,
12795,
9980,
310,
247,
14771,
38813,
15,
743,
38813,
310,
247,
5075,
390,
6906,
6308,
327,
271,
12235,
3402,
15,
6061,
673,
13,
841,
5075,
13977,
13726,
390,
23470,
562,
1955,
281,
1029,
2614,
3473,
15,
380,
6906,
8099,
273,
841,
23470,
272,
27627,
983,
476,
31430,
285,
28737,
2614,
715,
253,
2317,
8704,
3998,
1341,
15,
1780,
18631,
8099,
476,
671,
2740,
1527,
984,
597,
2489,
2349,
83,
15172,
13,
390,
6107,
342,
14126,
22413,
1925,
23861,
13,
6524,
7168,
616,
43546,
285,
2489,
1308,
1522,
13,
6906,
13,
285,
21291,
281,
33118,
15,
8305,
8292,
2452,
13,
390,
1029,
2614,
3473,
13,
5459,
253,
2495,
326,
247,
1308,
1522,
12235,
3402,
588,
1918,
1039,
285,
3727,
2614,
715,
253,
8704,
3998,
4408,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
310,
313,
609,
10,
659,
7292,
3736,
998,
7292,
1969,
329,
4165,
784,
11846,
329,
9980,
310,
4092,
13,
816,
751,
247,
2798,
2983,
15,
5815,
807,
275,
253,
1986,
2077,
13,
5512,
818,
2222,
13,
933,
952,
452,
247,
9980,
15,
11376,
43385,
13,
933,
273,
841,
403,
806,
390,
747,
33518,
15,
1623,
3388,
13,
581,
2448,
9778,
432,
9980,
1046,
1740,
2909,
15,
659,
7292,
310,
253,
7002,
4283,
2847,
273,
2471,
275,
253,
1986,
2077,
13,
285,
5997,
625,
4092,
1048,
14,
3945,
26545,
685,
667,
643,
2728,
15,
36388,
1264,
14,
14105,
273,
512,
33518,
2826,
275,
952,
689,
253,
2363,
273,
7251,
15,
1244,
253,
2495,
273,
1907,
247,
9980,
625,
685,
33478,
1016,
9976,
875,
253,
11880,
273,
7288,
285,
9330,
15,
659,
7292,
6634,
275,
512,
2363,
2390,
13,
275,
1097,
35717,
13,
285,
275,
512,
15820,
275,
1046,
2586,
15,
733,
476,
1014,
2826,
1078,
4201,
13,
672,
253,
36866,
310,
1335,
275,
253,
49009,
15,
20727,
670,
9980,
476,
1361,
368,
769,
275,
673,
281,
5321,
247,
4103,
13,
6346,
13,
390,
3331,
15,
1244,
2403,
2544,
275,
634,
14898,
476,
1361,
368,
3657,
9980,
15,
1737,
1680,
659,
7292,
32,
329,
9980,
310,
4536,
1925,
247,
346,
21590,
2983,
449,
5595,
2223,
13,
9980,
6634,
672,
2614,
2685,
281,
253,
3998,
14545,
984,
352,
310,
13230,
407,
247,
31301,
15,
2091,
436,
6569,
13,
253,
3998,
1341,
275,
253,
8993,
2170,
3135,
281,
3150,
15,
3808,
3998,
1341,
3150,
984,
597,
3523,
2970,
253,
7768,
285,
23491,
597,
878,
281,
1159,
15,
5131,
3998,
1341,
3150,
984,
597,
403,
13572,
407,
5982,
14771,
715,
390,
1475,
253,
3998,
15,
380,
3998,
1341,
326,
1053,
626,
3150,
4745,
3464,
387,
2495,
323,
2471,
15,
2053,
1341,
476,
45001,
275,
247,
25047,
390,
33153,
1375,
323,
2067,
3038,
15,
2726,
14793,
1971,
13,
841,
1341,
476,
320,
9809,
15,
1457,
9694,
403,
2130,
326,
10260,
4796,
253,
4723,
4269,
407,
247,
9980,
15,
1292,
368,
878,
281,
12666,
387,
253,
4675,
347,
3517,
347,
1896,
846,
5917,
1265,
281,
3657,
12564,
285,
281,
10260,
3157,
634,
14512,
323,
7355,
15,
40828,
9980,
5917,
13,
6789,
28546,
4745,
13,
285,
2970,
281,
247,
4675,
347,
4541,
347,
1896,
403,
4619,
15,
309,
20645,
280,
659,
7292,
1707,
403,
767,
9351,
273,
9980,
15,
380,
954,
1846,
2238,
273,
9980,
310,
1925,
23523,
9980,
15,
733,
8553,
323,
5512,
5096,
2558,
273,
512,
33518,
15,
743,
23523,
9980,
310,
4269,
407,
247,
2614,
31301,
326,
8336,
390,
49359,
247,
2614,
11179,
28106,
2614,
281,
253,
3998,
15,
15204,
1131,
326,
2847,
23523,
33518,
8424,
432,
1264,
2515,
27,
428,
253,
4702,
273,
247,
31301,
1561,
247,
2614,
11179,
273,
253,
3998,
390,
7623,
13,
1925,
34029,
50276,
14,
253,
4866,
273,
247,
31301,
432,
1529,
629,
273,
253,
2133,
13,
824,
347,
432,
253,
2798,
281,
253,
7623,
390,
3998,
13,
1925,
271,
37165,
1204,
50276,
14,
247,
5460,
44746,
273,
271,
12235,
313,
16750,
2433,
10,
275,
390,
4283,
281,
253,
3998,
13,
1955,
281,
14126,
22413,
27535,
253,
2614,
11179,
8099,
15,
253,
4702,
273,
247,
31301,
1561,
247,
2614,
11179,
273,
253,
3998,
390,
7623,
13,
1925,
34029,
253,
4866,
273,
247,
31301,
432,
1529,
629,
273,
253,
2133,
13,
824,
347,
432,
253,
2798,
281,
253,
7623,
390,
3998,
13,
1925,
271,
37165,
1204,
247,
5460,
44746,
273,
271,
12235,
313,
16750,
2433,
10,
275,
390,
4283,
281,
253,
3998,
13,
1955,
281,
14126,
22413,
27535,
253,
2614,
11179,
8099,
15,
18402,
17536,
12795,
659,
7292,
380,
643,
2238,
273,
9980,
310,
1925,
21699,
12795,
9980,
15,
329,
21699,
12795,
9980,
310,
4269,
407,
247,
2614,
11179,
326,
13471,
285,
7387,
5797,
715,
253,
3998,
15,
2596,
1846,
2847,
273,
247,
21699,
12795,
9980,
310,
247,
14771,
38813,
15,
743,
38813,
310,
247,
5075,
390,
6906,
6308,
327,
271,
12235,
3402,
15,
6061,
673,
13,
841,
5075,
13977,
13726,
390,
23470,
562,
1955,
281,
1029,
2614,
3473,
15,
380,
6906,
8099,
273,
841,
23470,
272,
27627,
983,
476,
31430,
285,
28737,
2614,
715,
253,
2317,
8704,
3998,
1341,
15,
1780,
18631,
8099,
476,
671,
2740,
1527,
984,
597,
2489,
2349,
83,
15172,
13,
390,
6107,
342,
14126,
22413,
1925,
23861,
13,
6524,
7168,
616,
43546,
285,
2489,
1308,
1522,
13,
6906,
13,
285,
21291,
281,
33118,
15,
8305,
8292,
2452,
13,
390,
1029,
2614,
3473,
13,
5459,
253,
2495,
326,
247,
1308,
1522,
12235,
3402,
588,
1918,
1039,
285,
3727,
2614,
715,
253,
8704,
3998,
4408,
15
] |
How to diagnose Madelung disease ? | How is Madelung disease diagnosed? Madelung disease is usually diagnosed based on a thorough physical exam, accurate medical history, and imaging studies - computed tomography (CT scan) and/or magnetic resonance imaging (MRI scan). A CT scan is an imaging method that uses x-rays to create pictures of cross-sections of the body, while an MRI scan uses powerful magnets and radio waves to create pictures of the lipomas and surrounding tissues. Both of these tests are useful in establishing a diagnosis of Madelung disease, although MRI is often the preferred method. In some cases, a biopsy of the lipomas may be necessary to confirm the diagnosis. | [
2347,
281,
33901,
6984,
293,
1947,
2728,
3736,
2347,
310,
6984,
293,
1947,
2728,
11245,
32,
6984,
293,
1947,
2728,
310,
3798,
11245,
1754,
327,
247,
11080,
3520,
1174,
13,
7899,
3739,
2892,
13,
285,
6979,
2175,
428,
10302,
20213,
313,
1647,
11017,
10,
285,
16,
263,
5212,
12549,
6979,
313,
22410,
11017,
481,
329,
7403,
11017,
310,
271,
6979,
1332,
326,
4648,
1269,
14,
20237,
281,
2794,
7968,
273,
2831,
14,
21454,
273,
253,
2133,
13,
1223,
271,
14478,
11017,
4648,
6422,
43733,
285,
5553,
10212,
281,
2794,
7968,
273,
253,
5541,
4921,
285,
8704,
7944,
15,
6295,
273,
841,
5216,
403,
4217,
275,
14631,
247,
6120,
273,
6984,
293,
1947,
2728,
13,
3738,
14478,
310,
2223,
253,
9013,
1332,
15,
496,
690,
2219,
13,
247,
18323,
273,
253,
5541,
4921,
778,
320,
3309,
281,
6583,
253,
6120,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
2347,
281,
33901,
6984,
293,
1947,
2728,
3736,
2347,
310,
6984,
293,
1947,
2728,
11245,
32,
6984,
293,
1947,
2728,
310,
3798,
11245,
1754,
327,
247,
11080,
3520,
1174,
13,
7899,
3739,
2892,
13,
285,
6979,
2175,
428,
10302,
20213,
313,
1647,
11017,
10,
285,
16,
263,
5212,
12549,
6979,
313,
22410,
11017,
481,
329,
7403,
11017,
310,
271,
6979,
1332,
326,
4648,
1269,
14,
20237,
281,
2794,
7968,
273,
2831,
14,
21454,
273,
253,
2133,
13,
1223,
271,
14478,
11017,
4648,
6422,
43733,
285,
5553,
10212,
281,
2794,
7968,
273,
253,
5541,
4921,
285,
8704,
7944,
15,
6295,
273,
841,
5216,
403,
4217,
275,
14631,
247,
6120,
273,
6984,
293,
1947,
2728,
13,
3738,
14478,
310,
2223,
253,
9013,
1332,
15,
496,
690,
2219,
13,
247,
18323,
273,
253,
5541,
4921,
778,
320,
3309,
281,
6583,
253,
6120,
15
] |
What are the treatments for Cystocele ? | Cystocele treatment depends on the severity of the cystocele and whether a woman has symptoms. If a womans cystocele does not bother her, a health care provider may recommend only that she avoid heavy lifting or straining, which could worsen her cystocele. If a woman has symptoms that bother her and wants treatment, the health care provider may recommend pelvic muscle exercises, a vaginal pessary, or surgery.
Pelvic floor, or Kegel, exercises involve strengthening pelvic floor muscles. Strong pelvic floor muscles more effectively hold pelvic organs in place. A woman does not need special equipment for Kegel exercises.
The exercises involve tightening and relaxing the muscles that support pelvic organs. A health care provider can help a woman learn proper technique.
More information about pelvic muscle exercises is provided in the NIDDK health topic, Kegel Exercise Tips.
A vaginal pessary is a small, silicone medical device placed in the vagina that supports the vaginal wall and holds the bladder in place. Pessaries come in a number of shapes and sizes. A health care provider has many options to choose from to find the most comfortable pessary for a woman.
A heath care provider may recommend surgery to repair the vaginal wall support and reposition the womans bladder to its normal position. The most common cystocele repair is an anterior vaginal repairor anterior colporrhaphy. The surgeon makes an incision in the wall of the womans vagina and repairs the defect by folding over and sewing together extra supportive tissue between the vagina and bladder. The repair tightens the layers of tissue that separate the organs, creating more support for the bladder. A surgeon who specializes in the urinary tract or female reproductive system performs an anterior vaginal repair in a hospital. The woman receives either regional or general anesthesia. The woman may stay overnight in the hospital, and full recovery may take up to 4 to 6 weeks. | [
1276,
403,
253,
9694,
323,
330,
9207,
80,
44033,
3736,
36,
9207,
80,
44033,
1971,
7024,
327,
253,
12147,
273,
253,
2645,
11769,
44033,
285,
1880,
247,
3416,
556,
5917,
15,
1310,
247,
1606,
507,
2645,
11769,
44033,
1057,
417,
15105,
617,
13,
247,
1786,
1557,
11716,
778,
5583,
760,
326,
703,
3693,
5536,
20284,
390,
3405,
1699,
13,
534,
812,
548,
8243,
617,
2645,
11769,
44033,
15,
1310,
247,
3416,
556,
5917,
326,
15105,
617,
285,
5605,
1971,
13,
253,
1786,
1557,
11716,
778,
5583,
31084,
6616,
18418,
13,
247,
27457,
25768,
552,
13,
390,
5869,
15,
187,
50262,
187,
49,
293,
19742,
5254,
13,
390,
611,
909,
293,
13,
18418,
6388,
31845,
31084,
5254,
13370,
15,
24747,
31084,
5254,
13370,
625,
8069,
2186,
31084,
15384,
275,
1659,
15,
329,
3416,
1057,
417,
878,
2714,
6500,
323,
611,
909,
293,
18418,
15,
187,
50262,
187,
510,
18418,
6388,
48594,
285,
32196,
253,
13370,
326,
1329,
31084,
15384,
15,
329,
1786,
1557,
11716,
476,
1361,
247,
3416,
3037,
1463,
5853,
15,
187,
50262,
187,
7673,
1491,
670,
31084,
6616,
18418,
310,
2530,
275,
253,
427,
1838,
49462,
1786,
9400,
13,
611,
909,
293,
40626,
41893,
15,
187,
50262,
187,
34,
27457,
25768,
552,
310,
247,
1355,
13,
35651,
3739,
2813,
4845,
275,
253,
42797,
326,
8525,
253,
27457,
3402,
285,
6556,
253,
18676,
275,
1659,
15,
367,
405,
3927,
1705,
275,
247,
1180,
273,
15029,
285,
9552,
15,
329,
1786,
1557,
11716,
556,
1142,
4610,
281,
5206,
432,
281,
1089,
253,
954,
9848,
25768,
552,
323,
247,
3416,
15,
187,
50262,
187,
34,
344,
506,
1557,
11716,
778,
5583,
5869,
281,
8706,
253,
27457,
3402,
1329,
285,
294,
3321,
253,
1606,
507,
18676,
281,
697,
2622,
1899,
15,
380,
954,
1846,
2645,
11769,
44033,
8706,
310,
271,
13235,
27457,
8706,
263,
13235,
847,
1831,
9492,
522,
1994,
15,
380,
20997,
2789,
271,
33708,
275,
253,
3402,
273,
253,
1606,
507,
42797,
285,
25931,
253,
7071,
407,
23205,
689,
285,
36787,
2366,
4465,
23384,
4408,
875,
253,
42797,
285,
18676,
15,
380,
8706,
6863,
561,
253,
8090,
273,
4408,
326,
4858,
253,
15384,
13,
6153,
625,
1329,
323,
253,
18676,
15,
329,
20997,
665,
46259,
275,
253,
19006,
10649,
390,
5343,
19448,
985,
17923,
271,
13235,
27457,
8706,
275,
247,
4675,
15,
380,
3416,
14488,
2057,
9933,
390,
2087,
25668,
15,
380,
3416,
778,
3297,
13463,
275,
253,
4675,
13,
285,
2120,
7355,
778,
1379,
598,
281,
577,
281,
721,
3618,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
403,
253,
9694,
323,
330,
9207,
80,
44033,
3736,
36,
9207,
80,
44033,
1971,
7024,
327,
253,
12147,
273,
253,
2645,
11769,
44033,
285,
1880,
247,
3416,
556,
5917,
15,
1310,
247,
1606,
507,
2645,
11769,
44033,
1057,
417,
15105,
617,
13,
247,
1786,
1557,
11716,
778,
5583,
760,
326,
703,
3693,
5536,
20284,
390,
3405,
1699,
13,
534,
812,
548,
8243,
617,
2645,
11769,
44033,
15,
1310,
247,
3416,
556,
5917,
326,
15105,
617,
285,
5605,
1971,
13,
253,
1786,
1557,
11716,
778,
5583,
31084,
6616,
18418,
13,
247,
27457,
25768,
552,
13,
390,
5869,
15,
187,
50262,
187,
49,
293,
19742,
5254,
13,
390,
611,
909,
293,
13,
18418,
6388,
31845,
31084,
5254,
13370,
15,
24747,
31084,
5254,
13370,
625,
8069,
2186,
31084,
15384,
275,
1659,
15,
329,
3416,
1057,
417,
878,
2714,
6500,
323,
611,
909,
293,
18418,
15,
187,
50262,
187,
510,
18418,
6388,
48594,
285,
32196,
253,
13370,
326,
1329,
31084,
15384,
15,
329,
1786,
1557,
11716,
476,
1361,
247,
3416,
3037,
1463,
5853,
15,
187,
50262,
187,
7673,
1491,
670,
31084,
6616,
18418,
310,
2530,
275,
253,
427,
1838,
49462,
1786,
9400,
13,
611,
909,
293,
40626,
41893,
15,
187,
50262,
187,
34,
27457,
25768,
552,
310,
247,
1355,
13,
35651,
3739,
2813,
4845,
275,
253,
42797,
326,
8525,
253,
27457,
3402,
285,
6556,
253,
18676,
275,
1659,
15,
367,
405,
3927,
1705,
275,
247,
1180,
273,
15029,
285,
9552,
15,
329,
1786,
1557,
11716,
556,
1142,
4610,
281,
5206,
432,
281,
1089,
253,
954,
9848,
25768,
552,
323,
247,
3416,
15,
187,
50262,
187,
34,
344,
506,
1557,
11716,
778,
5583,
5869,
281,
8706,
253,
27457,
3402,
1329,
285,
294,
3321,
253,
1606,
507,
18676,
281,
697,
2622,
1899,
15,
380,
954,
1846,
2645,
11769,
44033,
8706,
310,
271,
13235,
27457,
8706,
263,
13235,
847,
1831,
9492,
522,
1994,
15,
380,
20997,
2789,
271,
33708,
275,
253,
3402,
273,
253,
1606,
507,
42797,
285,
25931,
253,
7071,
407,
23205,
689,
285,
36787,
2366,
4465,
23384,
4408,
875,
253,
42797,
285,
18676,
15,
380,
8706,
6863,
561,
253,
8090,
273,
4408,
326,
4858,
253,
15384,
13,
6153,
625,
1329,
323,
253,
18676,
15,
329,
20997,
665,
46259,
275,
253,
19006,
10649,
390,
5343,
19448,
985,
17923,
271,
13235,
27457,
8706,
275,
247,
4675,
15,
380,
3416,
14488,
2057,
9933,
390,
2087,
25668,
15,
380,
3416,
778,
3297,
13463,
275,
253,
4675,
13,
285,
2120,
7355,
778,
1379,
598,
281,
577,
281,
721,
3618,
15
] |
What are the symptoms of Hypothyroidism ? | Hypothyroidism has many symptoms that can vary from person to person. Some common symptoms of hypothyroidism are
- fatigue - weight gain - a puffy face - cold intolerance - joint and muscle pain - constipation - dry skin - dry, thinning hair - decreased sweating - heavy or irregular menstrual periods and impaired fertility - depression - slowed heart rate
However, hypothyroidism develops slowly, so many people dont notice symptoms of the disease.
Symptoms more specific to Hashimotos disease are a goiter and a feeling of fullness in the throat.
Hypothyroidism can contribute to high cholesterol, so people with high cholesterol should be tested for hypothyroidism. Rarely, severe, untreated hypothyroidism may lead to myxedema coma, an extreme form of hypothyroidism in which the bodys functions slow to the point that it becomes life threatening. Myxedema requires immediate medical treatment. | [
1276,
403,
253,
5917,
273,
25295,
16715,
37739,
3736,
39355,
16715,
37739,
556,
1142,
5917,
326,
476,
6889,
432,
1436,
281,
1436,
15,
3808,
1846,
5917,
273,
3500,
16715,
37739,
403,
187,
50262,
187,
14,
18693,
50276,
14,
2801,
6351,
50276,
14,
247,
268,
26948,
2454,
50276,
14,
5412,
45458,
50276,
14,
6036,
285,
6616,
3075,
50276,
14,
1030,
32713,
50276,
14,
6079,
4808,
50276,
14,
6079,
13,
6906,
920,
4707,
50276,
14,
6137,
47425,
50276,
14,
5536,
390,
17948,
46182,
9894,
285,
15506,
27161,
50276,
14,
9454,
50276,
14,
28837,
2798,
2281,
187,
50262,
187,
6436,
13,
3500,
16715,
37739,
24357,
7808,
13,
594,
1142,
952,
13414,
4366,
5917,
273,
253,
2728,
15,
187,
50262,
187,
23875,
431,
3056,
625,
2173,
281,
22272,
303,
302,
375,
2728,
403,
247,
564,
2562,
285,
247,
5471,
273,
2120,
1255,
275,
253,
13386,
15,
187,
50262,
187,
39355,
16715,
37739,
476,
8162,
281,
1029,
13559,
13,
594,
952,
342,
1029,
13559,
943,
320,
5762,
323,
3500,
16715,
37739,
15,
44605,
314,
13,
5460,
13,
20716,
3500,
16715,
37739,
778,
1421,
281,
619,
89,
264,
8895,
45753,
13,
271,
9559,
830,
273,
3500,
16715,
37739,
275,
534,
253,
18400,
656,
3470,
3468,
281,
253,
1127,
326,
352,
4916,
1495,
18844,
15,
2752,
89,
264,
8895,
4419,
8993,
3739,
1971,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
403,
253,
5917,
273,
25295,
16715,
37739,
3736,
39355,
16715,
37739,
556,
1142,
5917,
326,
476,
6889,
432,
1436,
281,
1436,
15,
3808,
1846,
5917,
273,
3500,
16715,
37739,
403,
187,
50262,
187,
14,
18693,
50276,
14,
2801,
6351,
50276,
14,
247,
268,
26948,
2454,
50276,
14,
5412,
45458,
50276,
14,
6036,
285,
6616,
3075,
50276,
14,
1030,
32713,
50276,
14,
6079,
4808,
50276,
14,
6079,
13,
6906,
920,
4707,
50276,
14,
6137,
47425,
50276,
14,
5536,
390,
17948,
46182,
9894,
285,
15506,
27161,
50276,
14,
9454,
50276,
14,
28837,
2798,
2281,
187,
50262,
187,
6436,
13,
3500,
16715,
37739,
24357,
7808,
13,
594,
1142,
952,
13414,
4366,
5917,
273,
253,
2728,
15,
187,
50262,
187,
23875,
431,
3056,
625,
2173,
281,
22272,
303,
302,
375,
2728,
403,
247,
564,
2562,
285,
247,
5471,
273,
2120,
1255,
275,
253,
13386,
15,
187,
50262,
187,
39355,
16715,
37739,
476,
8162,
281,
1029,
13559,
13,
594,
952,
342,
1029,
13559,
943,
320,
5762,
323,
3500,
16715,
37739,
15,
44605,
314,
13,
5460,
13,
20716,
3500,
16715,
37739,
778,
1421,
281,
619,
89,
264,
8895,
45753,
13,
271,
9559,
830,
273,
3500,
16715,
37739,
275,
534,
253,
18400,
656,
3470,
3468,
281,
253,
1127,
326,
352,
4916,
1495,
18844,
15,
2752,
89,
264,
8895,
4419,
8993,
3739,
1971,
15
] |
What causes Factor V deficiency ? | What causes factor V deficiency? Factor V deficiency is caused by mutations in the F5 gene that prevent the production of a functional factor V protein or decrease the amount of the protein in the bloodstream. Mutations are present in both copies of the F5 gene in each cell, which prevents blood from clotting normally. | [
1276,
5997,
16090,
657,
14384,
3736,
1276,
5997,
2803,
657,
14384,
32,
16090,
657,
14384,
310,
4269,
407,
9197,
275,
253,
401,
22,
3320,
326,
3657,
253,
3275,
273,
247,
5164,
2803,
657,
2601,
390,
6379,
253,
2408,
273,
253,
2601,
275,
253,
2614,
4963,
15,
15601,
569,
403,
1246,
275,
1097,
10125,
273,
253,
401,
22,
3320,
275,
1016,
894,
13,
534,
16897,
2614,
432,
31301,
1076,
9403,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
5997,
16090,
657,
14384,
3736,
1276,
5997,
2803,
657,
14384,
32,
16090,
657,
14384,
310,
4269,
407,
9197,
275,
253,
401,
22,
3320,
326,
3657,
253,
3275,
273,
247,
5164,
2803,
657,
2601,
390,
6379,
253,
2408,
273,
253,
2601,
275,
253,
2614,
4963,
15,
15601,
569,
403,
1246,
275,
1097,
10125,
273,
253,
401,
22,
3320,
275,
1016,
894,
13,
534,
16897,
2614,
432,
31301,
1076,
9403,
15
] |
What is (are) Long QT syndrome 1 ? | Romano-Ward syndrome is the most common form of inherited long QT syndrome. Symptoms include arrhythmia, fainting, cardiac arrest, and sudden death. There are six different types of this syndrome, long QT 1 through 6. Each type is caused by a change in a different gene. The most prevalent form of long QT syndrome is long QT type 1. Long QT type 1 is caused by changes in the KCNQ1 gene. Romano-Ward syndrome is inherited in an autosomal dominant fashion. | [
1276,
310,
313,
609,
10,
8057,
48703,
9237,
337,
3736,
30998,
4692,
14,
56,
472,
9237,
310,
253,
954,
1846,
830,
273,
20265,
1048,
48703,
9237,
15,
40561,
3056,
2486,
38369,
571,
13,
46947,
1076,
13,
10177,
5263,
13,
285,
5982,
2471,
15,
1707,
403,
2800,
1027,
3510,
273,
436,
9237,
13,
1048,
48703,
337,
949,
721,
15,
5815,
1511,
310,
4269,
407,
247,
1818,
275,
247,
1027,
3320,
15,
380,
954,
21270,
830,
273,
1048,
48703,
9237,
310,
1048,
48703,
1511,
337,
15,
8057,
48703,
1511,
337,
310,
4269,
407,
2544,
275,
253,
611,
14546,
50,
18,
3320,
15,
9916,
4692,
14,
56,
472,
9237,
310,
20265,
275,
271,
48981,
11360,
8142,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
310,
313,
609,
10,
8057,
48703,
9237,
337,
3736,
30998,
4692,
14,
56,
472,
9237,
310,
253,
954,
1846,
830,
273,
20265,
1048,
48703,
9237,
15,
40561,
3056,
2486,
38369,
571,
13,
46947,
1076,
13,
10177,
5263,
13,
285,
5982,
2471,
15,
1707,
403,
2800,
1027,
3510,
273,
436,
9237,
13,
1048,
48703,
337,
949,
721,
15,
5815,
1511,
310,
4269,
407,
247,
1818,
275,
247,
1027,
3320,
15,
380,
954,
21270,
830,
273,
1048,
48703,
9237,
310,
1048,
48703,
1511,
337,
15,
8057,
48703,
1511,
337,
310,
4269,
407,
2544,
275,
253,
611,
14546,
50,
18,
3320,
15,
9916,
4692,
14,
56,
472,
9237,
310,
20265,
275,
271,
48981,
11360,
8142,
15
] |
What are the treatments for X-linked congenital stationary night blindness ? | These resources address the diagnosis or management of X-linked congenital stationary night blindness: - American Optometric Association: Infant Vision - Gene Review: Gene Review: X-Linked Congenital Stationary Night Blindness - Genetic Testing Registry: Congenital stationary night blindness - Genetic Testing Registry: Congenital stationary night blindness, type 1A - Genetic Testing Registry: Congenital stationary night blindness, type 2A - MedlinePlus Encyclopedia: Electroretinography - MedlinePlus Encyclopedia: Eye movements - Uncontrollable - MedlinePlus Encyclopedia: Nearsightedness - MedlinePlus Encyclopedia: Strabismus - MedlinePlus Encyclopedia: Vision - Night Blindness These resources from MedlinePlus offer information about the diagnosis and management of various health conditions: - Diagnostic Tests - Drug Therapy - Surgery and Rehabilitation - Genetic Counseling - Palliative Care | [
1276,
403,
253,
9694,
323,
1594,
14,
16862,
28296,
17429,
2360,
44868,
3736,
6872,
5300,
2953,
253,
6120,
390,
4323,
273,
1594,
14,
16862,
28296,
17429,
2360,
44868,
27,
50276,
14,
2448,
12551,
7480,
7115,
27,
13160,
386,
29770,
50276,
14,
15763,
8439,
27,
15763,
8439,
27,
1594,
14,
49967,
4731,
257,
1562,
14628,
552,
12972,
44892,
1255,
50276,
14,
37003,
30750,
38227,
27,
4731,
257,
1562,
17429,
2360,
44868,
50276,
14,
37003,
30750,
38227,
27,
4731,
257,
1562,
17429,
2360,
44868,
13,
1511,
337,
34,
50276,
14,
37003,
30750,
38227,
27,
4731,
257,
1562,
17429,
2360,
44868,
13,
1511,
374,
34,
50276,
14,
3050,
1282,
25263,
43338,
27,
38566,
1221,
249,
3756,
50276,
14,
3050,
1282,
25263,
43338,
27,
27919,
11438,
428,
914,
35019,
494,
50276,
14,
3050,
1282,
25263,
43338,
27,
427,
6364,
429,
264,
1255,
50276,
14,
3050,
1282,
25263,
43338,
27,
7962,
357,
47004,
50276,
14,
3050,
1282,
25263,
43338,
27,
29770,
428,
12972,
44892,
1255,
50275,
6872,
5300,
432,
3050,
1282,
25263,
3959,
1491,
670,
253,
6120,
285,
4323,
273,
2710,
1786,
2515,
27,
50276,
14,
44194,
32503,
50276,
14,
16686,
34294,
50276,
14,
34621,
285,
49251,
50276,
14,
37003,
19330,
272,
50275,
14,
42745,
18168,
9776
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
403,
253,
9694,
323,
1594,
14,
16862,
28296,
17429,
2360,
44868,
3736,
6872,
5300,
2953,
253,
6120,
390,
4323,
273,
1594,
14,
16862,
28296,
17429,
2360,
44868,
27,
50276,
14,
2448,
12551,
7480,
7115,
27,
13160,
386,
29770,
50276,
14,
15763,
8439,
27,
15763,
8439,
27,
1594,
14,
49967,
4731,
257,
1562,
14628,
552,
12972,
44892,
1255,
50276,
14,
37003,
30750,
38227,
27,
4731,
257,
1562,
17429,
2360,
44868,
50276,
14,
37003,
30750,
38227,
27,
4731,
257,
1562,
17429,
2360,
44868,
13,
1511,
337,
34,
50276,
14,
37003,
30750,
38227,
27,
4731,
257,
1562,
17429,
2360,
44868,
13,
1511,
374,
34,
50276,
14,
3050,
1282,
25263,
43338,
27,
38566,
1221,
249,
3756,
50276,
14,
3050,
1282,
25263,
43338,
27,
27919,
11438,
428,
914,
35019,
494,
50276,
14,
3050,
1282,
25263,
43338,
27,
427,
6364,
429,
264,
1255,
50276,
14,
3050,
1282,
25263,
43338,
27,
7962,
357,
47004,
50276,
14,
3050,
1282,
25263,
43338,
27,
29770,
428,
12972,
44892,
1255,
50275,
6872,
5300,
432,
3050,
1282,
25263,
3959,
1491,
670,
253,
6120,
285,
4323,
273,
2710,
1786,
2515,
27,
50276,
14,
44194,
32503,
50276,
14,
16686,
34294,
50276,
14,
34621,
285,
49251,
50276,
14,
37003,
19330,
272,
50275,
14,
42745,
18168,
9776
] |
What causes High Blood Cholesterol ? | Many factors can affect the cholesterol levels in your blood. You can control some factors, but not others.
Factors You Can Control
Diet
Cholesterol is found in foods that come from animal sources, such as egg yolks, meat, and cheese. Some foods have fats that raise your cholesterol level.
For example, saturated fat raises your low-density lipoprotein (LDL) cholesterol level more than anything else in your diet. Saturated fat is found in some meats, dairy products, chocolate, baked goods, and deep-fried and processed foods.
Trans fatty acids (trans fats) raise your LDL cholesterol and lower your high-density lipoprotein (HDL) cholesterol. Trans fats are made when hydrogen is added to vegetable oil to harden it. Trans fats are found in some fried and processed foods.
Limiting foods with cholesterol, saturated fat, and trans fats can help you control your cholesterol levels.
Physical Activity and Weight
Lack of physical activity can lead to weight gain. Being overweight tends to raise your LDL level, lower your HDL level, and increase your total cholesterol level. (Total cholesterol is a measure of the total amount of cholesterol in your blood, including LDL and HDL.)
Routine physical activity can help you lose weight and lower your LDL cholesterol. Being physically active also can help you raise your HDL cholesterol level.
Factors You Cant Control
Heredity
High blood cholesterol can run in families. An inherited condition called familial hypercholesterolemia causes very high LDL cholesterol. (Inherited means the condition is passed from parents to children through genes.) This condition begins at birth, and it may cause a heart attack at an early age.
Age and Sex
Starting at puberty, men often have lower levels of HDL cholesterol than women. As women and men age, their LDL cholesterol levels often rise. Before age 55, women usually have lower LDL cholesterol levels than men. However, afterage 55, women can have higher LDL levels than men. | [
1276,
5997,
4855,
14169,
775,
12050,
3736,
10195,
2616,
476,
2818,
253,
13559,
2308,
275,
634,
2614,
15,
1422,
476,
1453,
690,
2616,
13,
533,
417,
2571,
15,
187,
50262,
187,
34182,
641,
1422,
2615,
9175,
187,
50262,
187,
37,
2880,
187,
50262,
187,
1779,
12050,
310,
1119,
275,
12134,
326,
1705,
432,
5893,
4973,
13,
824,
347,
7238,
340,
311,
661,
13,
9132,
13,
285,
12173,
15,
3808,
12134,
452,
39100,
326,
7164,
634,
13559,
1268,
15,
187,
50262,
187,
2214,
1650,
13,
23543,
4688,
16540,
634,
1698,
14,
20425,
30823,
313,
44004,
10,
13559,
1268,
625,
685,
2712,
2010,
275,
634,
6196,
15,
322,
24668,
4688,
310,
1119,
275,
690,
47098,
13,
22759,
3580,
13,
14354,
13,
30363,
10229,
13,
285,
3676,
14,
41717,
285,
11742,
12134,
15,
187,
50262,
187,
6189,
14126,
9532,
313,
3675,
39100,
10,
7164,
634,
24219,
13559,
285,
2406,
634,
1029,
14,
20425,
30823,
313,
44139,
10,
13559,
15,
4480,
39100,
403,
1160,
672,
9946,
310,
2879,
281,
21436,
4166,
281,
1892,
257,
352,
15,
4480,
39100,
403,
1119,
275,
690,
31894,
285,
11742,
12134,
15,
187,
50262,
187,
36469,
2996,
12134,
342,
13559,
13,
23543,
4688,
13,
285,
811,
39100,
476,
1361,
368,
1453,
634,
13559,
2308,
15,
187,
50262,
187,
35227,
21907,
285,
27021,
187,
50262,
187,
45,
471,
273,
3520,
2425,
476,
1421,
281,
2801,
6351,
15,
16688,
26389,
14280,
281,
7164,
634,
24219,
1268,
13,
2406,
634,
27064,
1268,
13,
285,
2572,
634,
2264,
13559,
1268,
15,
313,
12481,
13559,
310,
247,
2557,
273,
253,
2264,
2408,
273,
13559,
275,
634,
2614,
13,
1690,
24219,
285,
27064,
2698,
187,
50262,
187,
48611,
460,
3520,
2425,
476,
1361,
368,
7168,
2801,
285,
2406,
634,
24219,
13559,
15,
16688,
13318,
3939,
671,
476,
1361,
368,
7164,
634,
27064,
13559,
1268,
15,
187,
50262,
187,
34182,
641,
1422,
21860,
9175,
187,
50262,
187,
1328,
433,
414,
187,
50262,
187,
12412,
2614,
13559,
476,
1408,
275,
5870,
15,
743,
20265,
1617,
1925,
36490,
4373,
348,
11201,
1306,
15604,
5997,
1077,
1029,
24219,
13559,
15,
313,
688,
379,
959,
2097,
253,
1617,
310,
4817,
432,
4651,
281,
2151,
949,
3608,
2698,
831,
1617,
9513,
387,
4201,
13,
285,
352,
778,
2847,
247,
2798,
2983,
387,
271,
2393,
2363,
15,
187,
50262,
187,
19711,
285,
16678,
187,
50262,
187,
33768,
387,
13384,
39731,
13,
1821,
2223,
452,
2406,
2308,
273,
27064,
13559,
685,
2255,
15,
1284,
2255,
285,
1821,
2363,
13,
616,
24219,
13559,
2308,
2223,
6054,
15,
9613,
2363,
7288,
13,
2255,
3798,
452,
2406,
24219,
13559,
2308,
685,
1821,
15,
1723,
13,
846,
486,
7288,
13,
2255,
476,
452,
2169,
24219,
2308,
685,
1821,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
5997,
4855,
14169,
775,
12050,
3736,
10195,
2616,
476,
2818,
253,
13559,
2308,
275,
634,
2614,
15,
1422,
476,
1453,
690,
2616,
13,
533,
417,
2571,
15,
187,
50262,
187,
34182,
641,
1422,
2615,
9175,
187,
50262,
187,
37,
2880,
187,
50262,
187,
1779,
12050,
310,
1119,
275,
12134,
326,
1705,
432,
5893,
4973,
13,
824,
347,
7238,
340,
311,
661,
13,
9132,
13,
285,
12173,
15,
3808,
12134,
452,
39100,
326,
7164,
634,
13559,
1268,
15,
187,
50262,
187,
2214,
1650,
13,
23543,
4688,
16540,
634,
1698,
14,
20425,
30823,
313,
44004,
10,
13559,
1268,
625,
685,
2712,
2010,
275,
634,
6196,
15,
322,
24668,
4688,
310,
1119,
275,
690,
47098,
13,
22759,
3580,
13,
14354,
13,
30363,
10229,
13,
285,
3676,
14,
41717,
285,
11742,
12134,
15,
187,
50262,
187,
6189,
14126,
9532,
313,
3675,
39100,
10,
7164,
634,
24219,
13559,
285,
2406,
634,
1029,
14,
20425,
30823,
313,
44139,
10,
13559,
15,
4480,
39100,
403,
1160,
672,
9946,
310,
2879,
281,
21436,
4166,
281,
1892,
257,
352,
15,
4480,
39100,
403,
1119,
275,
690,
31894,
285,
11742,
12134,
15,
187,
50262,
187,
36469,
2996,
12134,
342,
13559,
13,
23543,
4688,
13,
285,
811,
39100,
476,
1361,
368,
1453,
634,
13559,
2308,
15,
187,
50262,
187,
35227,
21907,
285,
27021,
187,
50262,
187,
45,
471,
273,
3520,
2425,
476,
1421,
281,
2801,
6351,
15,
16688,
26389,
14280,
281,
7164,
634,
24219,
1268,
13,
2406,
634,
27064,
1268,
13,
285,
2572,
634,
2264,
13559,
1268,
15,
313,
12481,
13559,
310,
247,
2557,
273,
253,
2264,
2408,
273,
13559,
275,
634,
2614,
13,
1690,
24219,
285,
27064,
2698,
187,
50262,
187,
48611,
460,
3520,
2425,
476,
1361,
368,
7168,
2801,
285,
2406,
634,
24219,
13559,
15,
16688,
13318,
3939,
671,
476,
1361,
368,
7164,
634,
27064,
13559,
1268,
15,
187,
50262,
187,
34182,
641,
1422,
21860,
9175,
187,
50262,
187,
1328,
433,
414,
187,
50262,
187,
12412,
2614,
13559,
476,
1408,
275,
5870,
15,
743,
20265,
1617,
1925,
36490,
4373,
348,
11201,
1306,
15604,
5997,
1077,
1029,
24219,
13559,
15,
313,
688,
379,
959,
2097,
253,
1617,
310,
4817,
432,
4651,
281,
2151,
949,
3608,
2698,
831,
1617,
9513,
387,
4201,
13,
285,
352,
778,
2847,
247,
2798,
2983,
387,
271,
2393,
2363,
15,
187,
50262,
187,
19711,
285,
16678,
187,
50262,
187,
33768,
387,
13384,
39731,
13,
1821,
2223,
452,
2406,
2308,
273,
27064,
13559,
685,
2255,
15,
1284,
2255,
285,
1821,
2363,
13,
616,
24219,
13559,
2308,
2223,
6054,
15,
9613,
2363,
7288,
13,
2255,
3798,
452,
2406,
24219,
13559,
2308,
685,
1821,
15,
1723,
13,
846,
486,
7288,
13,
2255,
476,
452,
2169,
24219,
2308,
685,
1821,
15
] |
What is (are) Male Breast Cancer ? | Key Points
- Male breast cancer is a disease in which malignant (cancer) cells form in the tissues of the breast. - Radiation exposure, high levels of estrogen, and a family history of breast cancer can increase a mans risk of breast cancer. - Male breast cancer is sometimes caused by inherited gene mutations (changes). - Men with breast cancer usually have lumps that can be felt. - Tests that examine the breasts are used to detect (find) and diagnose breast cancer in men. - If cancer is found, tests are done to study the cancer cells. - Survival for men with breast cancer is similar to survival for women with breast cancer. - Certain factors affect prognosis (chance of recovery) and treatment options.
Male breast cancer is a disease in which malignant (cancer) cells form in the tissues of the breast.
Breast cancer may occur in men. Men at any age may develop breast cancer, but it is usually detected (found) in men between 60 and 70 years of age. Male breast cancer makes up less than 1% of all cases of breast cancer. The following types of breast cancer are found in men: - Infiltrating ductal carcinoma: Cancer that has spread beyond the cells lining ducts in the breast. Most men with breast cancer have this type of cancer. - Ductal carcinoma in situ: Abnormal cells that are found in the lining of a duct; also called intraductal carcinoma. - Inflammatory breast cancer: A type of cancer in which the breast looks red and swollen and feels warm. - Paget disease of the nipple: A tumor that has grown from ducts beneath the nipple onto the surface of the nipple. Lobular carcinoma in situ (abnormal cells found in one of the lobes or sections of the breast), which sometimes occurs in women, has not been seen in men.
Men with breast cancer usually have lumps that can be felt.
Lumps and other signs may be caused by male breast cancer or by other conditions. Check with your doctor if you notice a change in your breasts. | [
1276,
310,
313,
609,
10,
23588,
41046,
13877,
3736,
4814,
31411,
187,
50258,
14,
23588,
5988,
2923,
310,
247,
2728,
275,
534,
17566,
313,
30366,
10,
1341,
830,
275,
253,
7944,
273,
253,
5988,
15,
50274,
14,
7754,
2492,
5445,
13,
1029,
2308,
273,
25149,
13,
285,
247,
2021,
2892,
273,
5988,
2923,
476,
2572,
247,
30433,
2495,
273,
5988,
2923,
15,
50273,
14,
23588,
5988,
2923,
310,
4536,
4269,
407,
20265,
3320,
9197,
313,
31973,
481,
50274,
14,
9730,
342,
5988,
2923,
3798,
452,
298,
10628,
326,
476,
320,
3543,
15,
50273,
14,
32503,
326,
9186,
253,
25960,
403,
908,
281,
2736,
313,
8606,
10,
285,
33901,
5988,
2923,
275,
1821,
15,
50274,
14,
1310,
2923,
310,
1119,
13,
5216,
403,
2218,
281,
1263,
253,
2923,
1341,
15,
50274,
14,
38312,
323,
1821,
342,
5988,
2923,
310,
2074,
281,
5788,
323,
2255,
342,
5988,
2923,
15,
50274,
14,
35110,
2616,
2818,
17102,
313,
348,
593,
273,
7355,
10,
285,
1971,
4610,
15,
187,
50262,
187,
50262,
187,
50258,
27346,
5988,
2923,
310,
247,
2728,
275,
534,
17566,
313,
30366,
10,
1341,
830,
275,
253,
7944,
273,
253,
5988,
15,
187,
50258,
16212,
505,
2923,
778,
2826,
275,
1821,
15,
9730,
387,
667,
2363,
778,
1287,
5988,
2923,
13,
533,
352,
310,
3798,
5189,
313,
14541,
10,
275,
1821,
875,
3925,
285,
5571,
1107,
273,
2363,
15,
23588,
5988,
2923,
2789,
598,
1679,
685,
337,
6,
273,
512,
2219,
273,
5988,
2923,
15,
50275,
510,
1563,
3510,
273,
5988,
2923,
403,
1119,
275,
1821,
27,
50269,
14,
50276,
688,
5073,
1206,
839,
17451,
267,
12382,
27,
13877,
326,
556,
5195,
4457,
253,
1341,
27535,
17451,
84,
275,
253,
5988,
15,
5595,
1821,
342,
5988,
2923,
452,
436,
1511,
273,
2923,
15,
50274,
14,
50276,
37,
10475,
267,
12382,
275,
5999,
27,
3506,
6320,
1341,
326,
403,
1119,
275,
253,
27535,
273,
247,
17451,
28,
671,
1925,
540,
4614,
10475,
267,
12382,
15,
50274,
14,
50276,
33675,
7030,
5988,
2923,
27,
329,
1511,
273,
2923,
275,
534,
253,
5988,
4453,
2502,
285,
37653,
285,
9193,
5890,
15,
50273,
14,
50276,
49,
356,
292,
2728,
273,
253,
295,
33687,
27,
329,
4502,
326,
556,
8228,
432,
17451,
84,
11834,
253,
295,
33687,
4830,
253,
2553,
273,
253,
295,
33687,
15,
50268,
45,
706,
792,
12382,
275,
5999,
313,
357,
6320,
1341,
1119,
275,
581,
273,
253,
43253,
390,
7118,
273,
253,
5988,
582,
534,
4536,
6634,
275,
2255,
13,
556,
417,
644,
2326,
275,
1821,
15,
187,
50262,
187,
50262,
187,
50258,
18812,
342,
5988,
2923,
3798,
452,
298,
10628,
326,
476,
320,
3543,
15,
187,
50258,
45,
10628,
285,
643,
7871,
778,
320,
4269,
407,
5086,
5988,
2923,
390,
407,
643,
2515,
15,
9423,
342,
634,
7345,
604,
368,
4366,
247,
1818,
275,
634,
25960,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
310,
313,
609,
10,
23588,
41046,
13877,
3736,
4814,
31411,
187,
50258,
14,
23588,
5988,
2923,
310,
247,
2728,
275,
534,
17566,
313,
30366,
10,
1341,
830,
275,
253,
7944,
273,
253,
5988,
15,
50274,
14,
7754,
2492,
5445,
13,
1029,
2308,
273,
25149,
13,
285,
247,
2021,
2892,
273,
5988,
2923,
476,
2572,
247,
30433,
2495,
273,
5988,
2923,
15,
50273,
14,
23588,
5988,
2923,
310,
4536,
4269,
407,
20265,
3320,
9197,
313,
31973,
481,
50274,
14,
9730,
342,
5988,
2923,
3798,
452,
298,
10628,
326,
476,
320,
3543,
15,
50273,
14,
32503,
326,
9186,
253,
25960,
403,
908,
281,
2736,
313,
8606,
10,
285,
33901,
5988,
2923,
275,
1821,
15,
50274,
14,
1310,
2923,
310,
1119,
13,
5216,
403,
2218,
281,
1263,
253,
2923,
1341,
15,
50274,
14,
38312,
323,
1821,
342,
5988,
2923,
310,
2074,
281,
5788,
323,
2255,
342,
5988,
2923,
15,
50274,
14,
35110,
2616,
2818,
17102,
313,
348,
593,
273,
7355,
10,
285,
1971,
4610,
15,
187,
50262,
187,
50262,
187,
50258,
27346,
5988,
2923,
310,
247,
2728,
275,
534,
17566,
313,
30366,
10,
1341,
830,
275,
253,
7944,
273,
253,
5988,
15,
187,
50258,
16212,
505,
2923,
778,
2826,
275,
1821,
15,
9730,
387,
667,
2363,
778,
1287,
5988,
2923,
13,
533,
352,
310,
3798,
5189,
313,
14541,
10,
275,
1821,
875,
3925,
285,
5571,
1107,
273,
2363,
15,
23588,
5988,
2923,
2789,
598,
1679,
685,
337,
6,
273,
512,
2219,
273,
5988,
2923,
15,
50275,
510,
1563,
3510,
273,
5988,
2923,
403,
1119,
275,
1821,
27,
50269,
14,
50276,
688,
5073,
1206,
839,
17451,
267,
12382,
27,
13877,
326,
556,
5195,
4457,
253,
1341,
27535,
17451,
84,
275,
253,
5988,
15,
5595,
1821,
342,
5988,
2923,
452,
436,
1511,
273,
2923,
15,
50274,
14,
50276,
37,
10475,
267,
12382,
275,
5999,
27,
3506,
6320,
1341,
326,
403,
1119,
275,
253,
27535,
273,
247,
17451,
28,
671,
1925,
540,
4614,
10475,
267,
12382,
15,
50274,
14,
50276,
33675,
7030,
5988,
2923,
27,
329,
1511,
273,
2923,
275,
534,
253,
5988,
4453,
2502,
285,
37653,
285,
9193,
5890,
15,
50273,
14,
50276,
49,
356,
292,
2728,
273,
253,
295,
33687,
27,
329,
4502,
326,
556,
8228,
432,
17451,
84,
11834,
253,
295,
33687,
4830,
253,
2553,
273,
253,
295,
33687,
15,
50268,
45,
706,
792,
12382,
275,
5999,
313,
357,
6320,
1341,
1119,
275,
581,
273,
253,
43253,
390,
7118,
273,
253,
5988,
582,
534,
4536,
6634,
275,
2255,
13,
556,
417,
644,
2326,
275,
1821,
15,
187,
50262,
187,
50262,
187,
50258,
18812,
342,
5988,
2923,
3798,
452,
298,
10628,
326,
476,
320,
3543,
15,
187,
50258,
45,
10628,
285,
643,
7871,
778,
320,
4269,
407,
5086,
5988,
2923,
390,
407,
643,
2515,
15,
9423,
342,
634,
7345,
604,
368,
4366,
247,
1818,
275,
634,
25960,
15
] |
What is (are) Leukemia ? | Radiation therapy is a cancer treatment that uses high-energy x-rays to destroy cancer cells. Some patients receive radiation treatment that is directed at the whole body. | [
1276,
310,
313,
609,
10,
2070,
2788,
9512,
3736,
13021,
2492,
4918,
310,
247,
2923,
1971,
326,
4648,
1029,
14,
14115,
1269,
14,
20237,
281,
6909,
2923,
1341,
15,
3808,
1363,
4763,
7742,
1971,
326,
310,
6828,
387,
253,
2644,
2133,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
310,
313,
609,
10,
2070,
2788,
9512,
3736,
13021,
2492,
4918,
310,
247,
2923,
1971,
326,
4648,
1029,
14,
14115,
1269,
14,
20237,
281,
6909,
2923,
1341,
15,
3808,
1363,
4763,
7742,
1971,
326,
310,
6828,
387,
253,
2644,
2133,
15
] |
What causes Congenital contractural arachnodactyly ? | What causes congenital contractural arachnodactyly? Congenital contractural arachnodactyly is caused by mutations in the FBN2 gene. The FBN2 gene provides instructions for producing the fibrillin-2 protein. Fibrillin-2 binds to other proteins and molecules to form threadlike filaments called microfibrils. Microfibrils become part of the fibers that provide strength and flexibility to connective tissue. Additionally, microfibrils hold molecules called growth factors and release them at the appropriate time to control the growth and repair of tissues and organs throughout the body. A mutation in the FBN2 gene can reduce the amount and/or quality of fibrillin-2 that is available to form microfibrils. As a result, decreased microfibril formation weakens the elastic fibers and allows growth factors to be released inappropriately, causing tall stature, deformities of the fingers and toes, and other characteristic features of congenital contractural arachnodactyly. | [
1276,
5997,
4731,
257,
1562,
3310,
1546,
549,
607,
41933,
514,
90,
314,
3736,
1276,
5997,
28296,
3310,
1546,
549,
607,
41933,
514,
90,
314,
32,
4731,
257,
1562,
3310,
1546,
549,
607,
41933,
514,
90,
314,
310,
4269,
407,
9197,
275,
253,
401,
17044,
19,
3320,
15,
380,
401,
17044,
19,
3320,
3400,
7997,
323,
9603,
253,
13244,
18013,
14,
19,
2601,
15,
401,
2560,
18013,
14,
19,
22294,
281,
643,
4324,
285,
8094,
281,
830,
6293,
3022,
31368,
1925,
2494,
71,
2560,
3683,
15,
12761,
71,
2560,
3683,
2489,
629,
273,
253,
13154,
326,
2085,
4757,
285,
15840,
281,
41292,
4408,
15,
9157,
13,
2494,
71,
2560,
3683,
2186,
8094,
1925,
3116,
2616,
285,
3727,
731,
387,
253,
4569,
673,
281,
1453,
253,
3116,
285,
8706,
273,
7944,
285,
15384,
4768,
253,
2133,
15,
329,
10577,
275,
253,
401,
17044,
19,
3320,
476,
4796,
253,
2408,
285,
16,
263,
3290,
273,
13244,
18013,
14,
19,
326,
310,
2130,
281,
830,
2494,
71,
2560,
3683,
15,
1284,
247,
906,
13,
6137,
2494,
71,
2560,
300,
4702,
5075,
561,
253,
15386,
13154,
285,
4483,
3116,
2616,
281,
320,
4439,
275,
13759,
1523,
13,
8479,
10086,
45540,
13,
22403,
1005,
273,
253,
9881,
285,
30106,
13,
285,
643,
8847,
3386,
273,
28296,
3310,
1546,
549,
607,
41933,
514,
90,
314,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
5997,
4731,
257,
1562,
3310,
1546,
549,
607,
41933,
514,
90,
314,
3736,
1276,
5997,
28296,
3310,
1546,
549,
607,
41933,
514,
90,
314,
32,
4731,
257,
1562,
3310,
1546,
549,
607,
41933,
514,
90,
314,
310,
4269,
407,
9197,
275,
253,
401,
17044,
19,
3320,
15,
380,
401,
17044,
19,
3320,
3400,
7997,
323,
9603,
253,
13244,
18013,
14,
19,
2601,
15,
401,
2560,
18013,
14,
19,
22294,
281,
643,
4324,
285,
8094,
281,
830,
6293,
3022,
31368,
1925,
2494,
71,
2560,
3683,
15,
12761,
71,
2560,
3683,
2489,
629,
273,
253,
13154,
326,
2085,
4757,
285,
15840,
281,
41292,
4408,
15,
9157,
13,
2494,
71,
2560,
3683,
2186,
8094,
1925,
3116,
2616,
285,
3727,
731,
387,
253,
4569,
673,
281,
1453,
253,
3116,
285,
8706,
273,
7944,
285,
15384,
4768,
253,
2133,
15,
329,
10577,
275,
253,
401,
17044,
19,
3320,
476,
4796,
253,
2408,
285,
16,
263,
3290,
273,
13244,
18013,
14,
19,
326,
310,
2130,
281,
830,
2494,
71,
2560,
3683,
15,
1284,
247,
906,
13,
6137,
2494,
71,
2560,
300,
4702,
5075,
561,
253,
15386,
13154,
285,
4483,
3116,
2616,
281,
320,
4439,
275,
13759,
1523,
13,
8479,
10086,
45540,
13,
22403,
1005,
273,
253,
9881,
285,
30106,
13,
285,
643,
8847,
3386,
273,
28296,
3310,
1546,
549,
607,
41933,
514,
90,
314,
15
] |
How many people are affected by tyrosine hydroxylase deficiency ? | The prevalence of TH deficiency is unknown. | [
2347,
1142,
952,
403,
5876,
407,
25367,
30721,
511,
14384,
3736,
510,
8996,
273,
4392,
14384,
310,
7202,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
2347,
1142,
952,
403,
5876,
407,
25367,
30721,
511,
14384,
3736,
510,
8996,
273,
4392,
14384,
310,
7202,
15
] |
What are the genetic changes related to familial restrictive cardiomyopathy ? | Mutations in several genes have been found to cause familial restrictive cardiomyopathy. Mutations in the TNNI3 gene are one of the major causes of this condition. The TNNI3 gene provides instructions for making a protein called cardiac troponin I, which is found solely in the heart. Cardiac troponin I is one of three proteins that make up the troponin protein complex, which helps regulate tensing (contraction) and relaxation of the heart muscle. TNNI3 gene mutations associated with familial restrictive cardiomyopathy result in the production of a defective cardiac troponin I protein. The altered protein disrupts the function of the troponin protein complex and does not allow the heart muscle to fully relax. As a result, not enough blood enters the ventricles, leading to a buildup in the atria and lungs. The abnormal heart relaxation and blood flow is responsible for many of the signs and symptoms of familial restrictive cardiomyopathy. Mutations in other genes associated with familial restrictive cardiomyopathy each account for a small percentage of cases of this condition. Some people with familial restrictive cardiomyopathy do not have an identified mutation in any of the known associated genes. The cause of the disorder in these individuals is unknown. | [
1276,
403,
253,
6380,
2544,
2905,
281,
36490,
29190,
50098,
3736,
31135,
569,
275,
2067,
3608,
452,
644,
1119,
281,
2847,
36490,
29190,
50098,
15,
15601,
569,
275,
253,
308,
8504,
42,
20,
3320,
403,
581,
273,
253,
2201,
5997,
273,
436,
1617,
15,
380,
308,
8504,
42,
20,
3320,
3400,
7997,
323,
2403,
247,
2601,
1925,
10177,
14404,
40341,
309,
13,
534,
310,
1119,
12718,
275,
253,
2798,
15,
9858,
14427,
14404,
40341,
309,
310,
581,
273,
1264,
4324,
326,
1056,
598,
253,
14404,
40341,
2601,
2570,
13,
534,
7729,
14368,
7114,
272,
313,
1987,
3460,
10,
285,
17040,
273,
253,
2798,
6616,
15,
50276,
53,
8504,
42,
20,
3320,
9197,
2330,
342,
36490,
29190,
50098,
906,
275,
253,
3275,
273,
247,
22327,
10177,
14404,
40341,
309,
2601,
15,
380,
12059,
2601,
13201,
84,
253,
1159,
273,
253,
14404,
40341,
2601,
2570,
285,
1057,
417,
1581,
253,
2798,
6616,
281,
4751,
7921,
15,
1284,
247,
906,
13,
417,
2217,
2614,
19413,
253,
28685,
868,
13,
4283,
281,
247,
1973,
484,
275,
253,
387,
5182,
285,
18926,
15,
380,
10969,
2798,
17040,
285,
2614,
2685,
310,
5506,
323,
1142,
273,
253,
7871,
285,
5917,
273,
36490,
29190,
50098,
15,
50276,
31135,
569,
275,
643,
3608,
2330,
342,
36490,
29190,
50098,
1016,
2395,
323,
247,
1355,
7155,
273,
2219,
273,
436,
1617,
15,
3808,
952,
342,
36490,
29190,
50098,
513,
417,
452,
271,
3636,
10577,
275,
667,
273,
253,
1929,
2330,
3608,
15,
380,
2847,
273,
253,
8984,
275,
841,
4292,
310,
7202,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
403,
253,
6380,
2544,
2905,
281,
36490,
29190,
50098,
3736,
31135,
569,
275,
2067,
3608,
452,
644,
1119,
281,
2847,
36490,
29190,
50098,
15,
15601,
569,
275,
253,
308,
8504,
42,
20,
3320,
403,
581,
273,
253,
2201,
5997,
273,
436,
1617,
15,
380,
308,
8504,
42,
20,
3320,
3400,
7997,
323,
2403,
247,
2601,
1925,
10177,
14404,
40341,
309,
13,
534,
310,
1119,
12718,
275,
253,
2798,
15,
9858,
14427,
14404,
40341,
309,
310,
581,
273,
1264,
4324,
326,
1056,
598,
253,
14404,
40341,
2601,
2570,
13,
534,
7729,
14368,
7114,
272,
313,
1987,
3460,
10,
285,
17040,
273,
253,
2798,
6616,
15,
50276,
53,
8504,
42,
20,
3320,
9197,
2330,
342,
36490,
29190,
50098,
906,
275,
253,
3275,
273,
247,
22327,
10177,
14404,
40341,
309,
2601,
15,
380,
12059,
2601,
13201,
84,
253,
1159,
273,
253,
14404,
40341,
2601,
2570,
285,
1057,
417,
1581,
253,
2798,
6616,
281,
4751,
7921,
15,
1284,
247,
906,
13,
417,
2217,
2614,
19413,
253,
28685,
868,
13,
4283,
281,
247,
1973,
484,
275,
253,
387,
5182,
285,
18926,
15,
380,
10969,
2798,
17040,
285,
2614,
2685,
310,
5506,
323,
1142,
273,
253,
7871,
285,
5917,
273,
36490,
29190,
50098,
15,
50276,
31135,
569,
275,
643,
3608,
2330,
342,
36490,
29190,
50098,
1016,
2395,
323,
247,
1355,
7155,
273,
2219,
273,
436,
1617,
15,
3808,
952,
342,
36490,
29190,
50098,
513,
417,
452,
271,
3636,
10577,
275,
667,
273,
253,
1929,
2330,
3608,
15,
380,
2847,
273,
253,
8984,
275,
841,
4292,
310,
7202,
15
] |
What is the outlook for Krabbe Disease ? | Krabbe disease in infants is generally fatal before age 2. Individuals with a later onset form of the disease generally have a milder course of the disease and live significantly longer. | [
1276,
310,
253,
29338,
323,
17145,
357,
1257,
18742,
3736,
44,
37588,
1257,
2728,
275,
15330,
310,
3839,
15444,
1078,
2363,
374,
15,
40788,
342,
247,
1996,
11653,
830,
273,
253,
2728,
3839,
452,
247,
2301,
491,
2282,
273,
253,
2728,
285,
3153,
3012,
3356,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
310,
253,
29338,
323,
17145,
357,
1257,
18742,
3736,
44,
37588,
1257,
2728,
275,
15330,
310,
3839,
15444,
1078,
2363,
374,
15,
40788,
342,
247,
1996,
11653,
830,
273,
253,
2728,
3839,
452,
247,
2301,
491,
2282,
273,
253,
2728,
285,
3153,
3012,
3356,
15
] |
What are the treatments for alveolar capillary dysplasia with misalignment of pulmonary veins ? | These resources address the diagnosis or management of ACD/MPV: - Genetic Testing Registry: Alveolar capillary dysplasia with misalignment of pulmonary veins - MedlinePlus Encyclopedia: Alveolar Abnormalities These resources from MedlinePlus offer information about the diagnosis and management of various health conditions: - Diagnostic Tests - Drug Therapy - Surgery and Rehabilitation - Genetic Counseling - Palliative Care | [
1276,
403,
253,
9694,
323,
34011,
26802,
48723,
342,
3731,
40446,
273,
12698,
27394,
3736,
6872,
5300,
2953,
253,
6120,
390,
4323,
273,
329,
3717,
16,
4548,
55,
27,
50276,
14,
37003,
30750,
38227,
27,
1219,
27971,
26802,
48723,
342,
3731,
40446,
273,
12698,
27394,
50276,
14,
3050,
1282,
25263,
43338,
27,
1219,
27971,
3506,
6320,
1005,
50275,
6872,
5300,
432,
3050,
1282,
25263,
3959,
1491,
670,
253,
6120,
285,
4323,
273,
2710,
1786,
2515,
27,
50276,
14,
44194,
32503,
50276,
14,
16686,
34294,
50276,
14,
34621,
285,
49251,
50276,
14,
37003,
19330,
272,
50275,
14,
42745,
18168,
9776
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
403,
253,
9694,
323,
34011,
26802,
48723,
342,
3731,
40446,
273,
12698,
27394,
3736,
6872,
5300,
2953,
253,
6120,
390,
4323,
273,
329,
3717,
16,
4548,
55,
27,
50276,
14,
37003,
30750,
38227,
27,
1219,
27971,
26802,
48723,
342,
3731,
40446,
273,
12698,
27394,
50276,
14,
3050,
1282,
25263,
43338,
27,
1219,
27971,
3506,
6320,
1005,
50275,
6872,
5300,
432,
3050,
1282,
25263,
3959,
1491,
670,
253,
6120,
285,
4323,
273,
2710,
1786,
2515,
27,
50276,
14,
44194,
32503,
50276,
14,
16686,
34294,
50276,
14,
34621,
285,
49251,
50276,
14,
37003,
19330,
272,
50275,
14,
42745,
18168,
9776
] |
What are the symptoms of Proximal chromosome 18q deletion syndrome ? | What are the signs and symptoms of Proximal chromosome 18q deletion syndrome? The Human Phenotype Ontology provides the following list of signs and symptoms for Proximal chromosome 18q deletion syndrome. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Absence of the pulmonary valve - Aortic valve stenosis - Asthma - Atopic dermatitis - Atresia of the external auditory canal - Atria septal defect - Autosomal dominant inheritance - Bifid uvula - Blepharophimosis - Broad-based gait - Cerebellar hypoplasia - Choanal stenosis - Chorea - Cleft palate - Cleft upper lip - Conductive hearing impairment - Congestive heart failure - Cryptorchidism - Delayed CNS myelination - Depressed nasal bridge - Dilatation of the ascending aorta - Downturned corners of mouth - Dysplastic aortic valve - Dysplastic pulmonary valve - Epicanthus - Failure to thrive in infancy - Flat midface - Growth hormone deficiency - Hypertelorism - Hypoplasia of midface - Hypospadias - Inguinal hernia - Intellectual disability - Joint laxity - Low anterior hairline - Macrotia - Malar flattening - Mandibular prognathia - Microcephaly - Micropenis - Motor delay - Muscular hypotonia - Nystagmus - Optic atrophy - Overlapping toe - Patent ductus arteriosus - Pes cavus - Pes planus - Phenotypic variability - Poor coordination - Prominent nose - Proximal placement of thumb - Recurrent respiratory infections - Rocker bottom foot - Scoliosis - Secretory IgA deficiency - Seizures - Sensorineural hearing impairment - Short neck - Short palpebral fissure - Short philtrum - Short stature - Sporadic - Stenosis of the external auditory canal - Strabismus - Talipes equinovarus - Tapetoretinal degeneration - Toe syndactyly - Tremor - Umbilical hernia - U-Shaped upper lip vermilion - Ventricular septal defect - Ventriculomegaly - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common. | [
1276,
403,
253,
5917,
273,
1294,
89,
1983,
15406,
1283,
82,
17404,
9237,
3736,
1276,
403,
253,
7871,
285,
5917,
273,
1294,
89,
1983,
15406,
1283,
82,
17404,
9237,
32,
380,
8801,
34689,
5174,
15195,
1497,
3400,
253,
1563,
1618,
273,
7871,
285,
5917,
323,
1294,
89,
1983,
15406,
1283,
82,
17404,
9237,
15,
1310,
253,
1491,
310,
2130,
13,
253,
2829,
2708,
3797,
849,
2223,
253,
19831,
310,
2326,
275,
952,
342,
436,
1617,
15,
1422,
476,
897,
253,
3050,
1282,
25263,
8710,
26372,
281,
1007,
598,
253,
14308,
323,
841,
3739,
2426,
15,
8714,
84,
285,
40561,
3056,
17274,
13954,
1180,
273,
1363,
313,
9453,
2130,
10,
16508,
566,
273,
253,
12698,
11059,
428,
329,
15230,
11059,
29940,
428,
15123,
14894,
428,
2058,
6361,
29863,
5895,
428,
2058,
373,
571,
273,
253,
6024,
26618,
19913,
428,
2058,
5182,
22688,
267,
7071,
428,
5271,
13304,
11360,
24954,
428,
378,
338,
301,
46556,
3627,
428,
35526,
545,
274,
2689,
303,
2433,
428,
13796,
14,
3169,
31262,
428,
330,
11892,
67,
8739,
3500,
4488,
13411,
428,
13999,
14983,
29940,
428,
775,
46080,
428,
330,
1274,
45238,
428,
330,
1274,
5170,
5541,
428,
36052,
422,
4854,
15151,
428,
4731,
383,
422,
2798,
4433,
428,
28451,
263,
42290,
1204,
428,
6304,
19416,
27102,
16203,
1515,
428,
3315,
2079,
23761,
9729,
428,
37723,
45510,
273,
253,
20474,
35688,
428,
9792,
28302,
18803,
273,
6208,
428,
399,
656,
32502,
22678,
11059,
428,
399,
656,
32502,
12698,
11059,
428,
39688,
386,
10034,
428,
32104,
281,
34298,
275,
42986,
428,
36682,
4260,
1664,
428,
27219,
14689,
14384,
428,
8305,
8292,
293,
263,
1204,
428,
25295,
4488,
13411,
273,
4260,
1664,
428,
8305,
993,
11022,
6358,
428,
496,
4297,
989,
617,
15298,
428,
17545,
37246,
12564,
428,
23106,
46948,
414,
428,
11578,
13235,
4707,
1282,
428,
5602,
8601,
571,
428,
5979,
274,
30627,
2980,
428,
18150,
27186,
11150,
506,
571,
428,
12761,
336,
545,
5242,
428,
10929,
1658,
257,
261,
428,
18521,
5778,
428,
4878,
2772,
37251,
9409,
428,
427,
9207,
356,
14557,
428,
12551,
280,
34512,
428,
6061,
77,
5436,
25283,
428,
11754,
17451,
316,
7463,
3783,
316,
428,
50035,
9605,
316,
428,
50035,
2098,
316,
428,
34689,
19671,
13099,
428,
28897,
19915,
428,
13798,
14622,
11480,
428,
1294,
89,
1983,
14663,
273,
17300,
428,
4568,
5732,
11900,
10332,
428,
9384,
254,
5004,
3174,
428,
1810,
10424,
2433,
428,
7743,
590,
45213,
14384,
428,
1023,
478,
980,
428,
322,
11313,
460,
1546,
4854,
15151,
428,
14196,
7623,
428,
14196,
5796,
365,
11887,
269,
739,
459,
428,
14196,
30005,
1206,
360,
428,
14196,
45540,
428,
322,
1831,
18535,
428,
659,
257,
2433,
273,
253,
6024,
26618,
19913,
428,
7962,
357,
47004,
428,
12636,
28964,
1298,
249,
729,
33858,
428,
37113,
292,
7262,
989,
27939,
428,
1916,
70,
7979,
514,
90,
314,
428,
308,
2013,
263,
428,
530,
1814,
300,
474,
617,
15298,
428,
530,
14,
2809,
7760,
5170,
5541,
2336,
22009,
279,
428,
23780,
13267,
22688,
267,
7071,
428,
657,
19458,
335,
485,
72,
5242,
428,
380,
8801,
34689,
5174,
15195,
1497,
313,
41,
5964,
10,
556,
5728,
1491,
327,
849,
2223,
247,
861,
390,
19831,
6634,
275,
247,
1617,
15,
18770,
273,
436,
1491,
3249,
432,
2207,
15671,
292,
13,
247,
5284,
7520,
2728,
5447,
15,
380,
4294,
273,
247,
861,
390,
19831,
310,
3798,
7117,
347,
247,
7227,
6642,
273,
253,
7155,
273,
1363,
665,
452,
326,
4735,
15,
380,
4294,
778,
671,
320,
7117,
347,
247,
6919,
15,
380,
806,
1180,
273,
253,
6919,
310,
849,
1142,
952,
574,
253,
19831,
13,
285,
253,
1273,
1180,
310,
253,
2264,
1180,
273,
952,
665,
497,
6730,
275,
581,
1263,
15,
1198,
1650,
13,
247,
4294,
273,
2030,
16,
1099,
2097,
326,
275,
247,
1263,
273,
2030,
952,
512,
1363,
497,
1119,
281,
452,
326,
19831,
15,
4923,
841,
11383,
403,
1754,
327,
247,
2173,
1263,
13,
253,
17711,
778,
320,
1027,
604,
1529,
1387,
273,
1363,
403,
6730,
15,
13168,
13,
642,
1491,
327,
4294,
310,
2130,
15,
496,
841,
2219,
13,
253,
861,
390,
19831,
778,
320,
7520,
390,
1846,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
403,
253,
5917,
273,
1294,
89,
1983,
15406,
1283,
82,
17404,
9237,
3736,
1276,
403,
253,
7871,
285,
5917,
273,
1294,
89,
1983,
15406,
1283,
82,
17404,
9237,
32,
380,
8801,
34689,
5174,
15195,
1497,
3400,
253,
1563,
1618,
273,
7871,
285,
5917,
323,
1294,
89,
1983,
15406,
1283,
82,
17404,
9237,
15,
1310,
253,
1491,
310,
2130,
13,
253,
2829,
2708,
3797,
849,
2223,
253,
19831,
310,
2326,
275,
952,
342,
436,
1617,
15,
1422,
476,
897,
253,
3050,
1282,
25263,
8710,
26372,
281,
1007,
598,
253,
14308,
323,
841,
3739,
2426,
15,
8714,
84,
285,
40561,
3056,
17274,
13954,
1180,
273,
1363,
313,
9453,
2130,
10,
16508,
566,
273,
253,
12698,
11059,
428,
329,
15230,
11059,
29940,
428,
15123,
14894,
428,
2058,
6361,
29863,
5895,
428,
2058,
373,
571,
273,
253,
6024,
26618,
19913,
428,
2058,
5182,
22688,
267,
7071,
428,
5271,
13304,
11360,
24954,
428,
378,
338,
301,
46556,
3627,
428,
35526,
545,
274,
2689,
303,
2433,
428,
13796,
14,
3169,
31262,
428,
330,
11892,
67,
8739,
3500,
4488,
13411,
428,
13999,
14983,
29940,
428,
775,
46080,
428,
330,
1274,
45238,
428,
330,
1274,
5170,
5541,
428,
36052,
422,
4854,
15151,
428,
4731,
383,
422,
2798,
4433,
428,
28451,
263,
42290,
1204,
428,
6304,
19416,
27102,
16203,
1515,
428,
3315,
2079,
23761,
9729,
428,
37723,
45510,
273,
253,
20474,
35688,
428,
9792,
28302,
18803,
273,
6208,
428,
399,
656,
32502,
22678,
11059,
428,
399,
656,
32502,
12698,
11059,
428,
39688,
386,
10034,
428,
32104,
281,
34298,
275,
42986,
428,
36682,
4260,
1664,
428,
27219,
14689,
14384,
428,
8305,
8292,
293,
263,
1204,
428,
25295,
4488,
13411,
273,
4260,
1664,
428,
8305,
993,
11022,
6358,
428,
496,
4297,
989,
617,
15298,
428,
17545,
37246,
12564,
428,
23106,
46948,
414,
428,
11578,
13235,
4707,
1282,
428,
5602,
8601,
571,
428,
5979,
274,
30627,
2980,
428,
18150,
27186,
11150,
506,
571,
428,
12761,
336,
545,
5242,
428,
10929,
1658,
257,
261,
428,
18521,
5778,
428,
4878,
2772,
37251,
9409,
428,
427,
9207,
356,
14557,
428,
12551,
280,
34512,
428,
6061,
77,
5436,
25283,
428,
11754,
17451,
316,
7463,
3783,
316,
428,
50035,
9605,
316,
428,
50035,
2098,
316,
428,
34689,
19671,
13099,
428,
28897,
19915,
428,
13798,
14622,
11480,
428,
1294,
89,
1983,
14663,
273,
17300,
428,
4568,
5732,
11900,
10332,
428,
9384,
254,
5004,
3174,
428,
1810,
10424,
2433,
428,
7743,
590,
45213,
14384,
428,
1023,
478,
980,
428,
322,
11313,
460,
1546,
4854,
15151,
428,
14196,
7623,
428,
14196,
5796,
365,
11887,
269,
739,
459,
428,
14196,
30005,
1206,
360,
428,
14196,
45540,
428,
322,
1831,
18535,
428,
659,
257,
2433,
273,
253,
6024,
26618,
19913,
428,
7962,
357,
47004,
428,
12636,
28964,
1298,
249,
729,
33858,
428,
37113,
292,
7262,
989,
27939,
428,
1916,
70,
7979,
514,
90,
314,
428,
308,
2013,
263,
428,
530,
1814,
300,
474,
617,
15298,
428,
530,
14,
2809,
7760,
5170,
5541,
2336,
22009,
279,
428,
23780,
13267,
22688,
267,
7071,
428,
657,
19458,
335,
485,
72,
5242,
428,
380,
8801,
34689,
5174,
15195,
1497,
313,
41,
5964,
10,
556,
5728,
1491,
327,
849,
2223,
247,
861,
390,
19831,
6634,
275,
247,
1617,
15,
18770,
273,
436,
1491,
3249,
432,
2207,
15671,
292,
13,
247,
5284,
7520,
2728,
5447,
15,
380,
4294,
273,
247,
861,
390,
19831,
310,
3798,
7117,
347,
247,
7227,
6642,
273,
253,
7155,
273,
1363,
665,
452,
326,
4735,
15,
380,
4294,
778,
671,
320,
7117,
347,
247,
6919,
15,
380,
806,
1180,
273,
253,
6919,
310,
849,
1142,
952,
574,
253,
19831,
13,
285,
253,
1273,
1180,
310,
253,
2264,
1180,
273,
952,
665,
497,
6730,
275,
581,
1263,
15,
1198,
1650,
13,
247,
4294,
273,
2030,
16,
1099,
2097,
326,
275,
247,
1263,
273,
2030,
952,
512,
1363,
497,
1119,
281,
452,
326,
19831,
15,
4923,
841,
11383,
403,
1754,
327,
247,
2173,
1263,
13,
253,
17711,
778,
320,
1027,
604,
1529,
1387,
273,
1363,
403,
6730,
15,
13168,
13,
642,
1491,
327,
4294,
310,
2130,
15,
496,
841,
2219,
13,
253,
861,
390,
19831,
778,
320,
7520,
390,
1846,
15
] |
What is (are) Progressive bulbar palsy ? | Progressive bulbar palsy involves the brain stem. The brain stem is the part of the brain needed for swallowing, speaking, chewing, and other functions. Signs and symptoms of progressive bulbar palsy include difficulty swallowing, weak jaw and facial muscles, progressive loss of speech, and weakening of the tongue. Additional symptoms include less prominent weakness in the arms and legs, and outbursts of laughing or crying (called emotional lability). Progressive bulbar palsy is considered a variant form of amyotrophic lateral sclerosis (ALS). Many people with progressive bulbar palsy later develop ALS. While there is no cure for progressive bulbar palsy or for ALS, doctors can treat symptoms. | [
1276,
310,
313,
609,
10,
39935,
5152,
2009,
39839,
90,
3736,
1845,
11020,
5152,
2009,
39839,
90,
8687,
253,
3998,
8424,
15,
380,
3998,
8424,
310,
253,
629,
273,
253,
3998,
3058,
323,
49646,
13,
8288,
13,
41927,
13,
285,
643,
3470,
15,
8714,
84,
285,
5917,
273,
13439,
5152,
2009,
39839,
90,
2486,
10183,
49646,
13,
5075,
21065,
285,
17754,
13370,
13,
13439,
2957,
273,
6519,
13,
285,
49060,
273,
253,
14018,
15,
14117,
5917,
2486,
1679,
11906,
14855,
275,
253,
6174,
285,
9246,
13,
285,
562,
13156,
7752,
273,
17053,
390,
17800,
313,
8890,
8991,
298,
1430,
481,
39935,
5152,
2009,
39839,
90,
310,
2783,
247,
12955,
830,
273,
717,
90,
44456,
11884,
33565,
313,
16755,
481,
6676,
952,
342,
13439,
5152,
2009,
39839,
90,
1996,
1287,
38410,
15,
3900,
627,
310,
642,
16498,
323,
13439,
5152,
2009,
39839,
90,
390,
323,
38410,
13,
11576,
476,
1555,
5917,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
310,
313,
609,
10,
39935,
5152,
2009,
39839,
90,
3736,
1845,
11020,
5152,
2009,
39839,
90,
8687,
253,
3998,
8424,
15,
380,
3998,
8424,
310,
253,
629,
273,
253,
3998,
3058,
323,
49646,
13,
8288,
13,
41927,
13,
285,
643,
3470,
15,
8714,
84,
285,
5917,
273,
13439,
5152,
2009,
39839,
90,
2486,
10183,
49646,
13,
5075,
21065,
285,
17754,
13370,
13,
13439,
2957,
273,
6519,
13,
285,
49060,
273,
253,
14018,
15,
14117,
5917,
2486,
1679,
11906,
14855,
275,
253,
6174,
285,
9246,
13,
285,
562,
13156,
7752,
273,
17053,
390,
17800,
313,
8890,
8991,
298,
1430,
481,
39935,
5152,
2009,
39839,
90,
310,
2783,
247,
12955,
830,
273,
717,
90,
44456,
11884,
33565,
313,
16755,
481,
6676,
952,
342,
13439,
5152,
2009,
39839,
90,
1996,
1287,
38410,
15,
3900,
627,
310,
642,
16498,
323,
13439,
5152,
2009,
39839,
90,
390,
323,
38410,
13,
11576,
476,
1555,
5917,
15
] |
What are the genetic changes related to congenital insensitivity to pain with anhidrosis ? | Mutations in the NTRK1 gene cause CIPA. The NTRK1 gene provides instructions for making a receptor protein that attaches (binds) to another protein called NGF. The NTRK1 receptor is important for the survival of nerve cells (neurons). The NTRK1 receptor is found on the surface of cells, particularly neurons that transmit pain, temperature, and touch sensations (sensory neurons). When the NGF protein binds to the NTRK1 receptor, signals are transmitted inside the cell that tell the cell to grow and divide, and that help it survive. Mutations in the NTRK1 gene lead to a protein that cannot transmit signals. Without the proper signaling, neurons die by a process of self-destruction called apoptosis. Loss of sensory neurons leads to the inability to feel pain in people with CIPA. In addition, people with CIPA lose the nerves leading to their sweat glands, which causes the anhidrosis seen in affected individuals. | [
1276,
403,
253,
6380,
2544,
2905,
281,
28296,
1210,
22247,
281,
3075,
342,
271,
73,
301,
11503,
3736,
31135,
569,
275,
253,
427,
3125,
44,
18,
3320,
2847,
330,
3123,
34,
15,
380,
427,
3125,
44,
18,
3320,
3400,
7997,
323,
2403,
247,
6437,
2601,
326,
863,
3844,
313,
13245,
84,
10,
281,
1529,
2601,
1925,
427,
4161,
15,
380,
427,
3125,
44,
18,
6437,
310,
1774,
323,
253,
5788,
273,
11083,
1341,
313,
32167,
790,
481,
50276,
510,
427,
3125,
44,
18,
6437,
310,
1119,
327,
253,
2553,
273,
1341,
13,
3782,
8512,
326,
13185,
3075,
13,
3276,
13,
285,
5181,
41868,
313,
6209,
590,
8512,
481,
2091,
253,
427,
4161,
2601,
22294,
281,
253,
427,
3125,
44,
18,
6437,
13,
6298,
403,
12573,
3304,
253,
894,
326,
2028,
253,
894,
281,
1756,
285,
10957,
13,
285,
326,
1361,
352,
11883,
15,
15601,
569,
275,
253,
427,
3125,
44,
18,
3320,
1421,
281,
247,
2601,
326,
2550,
13185,
6298,
15,
12414,
253,
1463,
7601,
13,
8512,
3150,
407,
247,
1232,
273,
1881,
14,
10812,
2705,
1925,
10596,
15,
28622,
273,
17872,
8512,
5644,
281,
253,
19297,
281,
1928,
3075,
275,
952,
342,
330,
3123,
34,
15,
496,
1635,
13,
952,
342,
330,
3123,
34,
7168,
253,
22614,
4283,
281,
616,
17052,
29108,
13,
534,
5997,
253,
271,
73,
301,
11503,
2326,
275,
5876,
4292,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
403,
253,
6380,
2544,
2905,
281,
28296,
1210,
22247,
281,
3075,
342,
271,
73,
301,
11503,
3736,
31135,
569,
275,
253,
427,
3125,
44,
18,
3320,
2847,
330,
3123,
34,
15,
380,
427,
3125,
44,
18,
3320,
3400,
7997,
323,
2403,
247,
6437,
2601,
326,
863,
3844,
313,
13245,
84,
10,
281,
1529,
2601,
1925,
427,
4161,
15,
380,
427,
3125,
44,
18,
6437,
310,
1774,
323,
253,
5788,
273,
11083,
1341,
313,
32167,
790,
481,
50276,
510,
427,
3125,
44,
18,
6437,
310,
1119,
327,
253,
2553,
273,
1341,
13,
3782,
8512,
326,
13185,
3075,
13,
3276,
13,
285,
5181,
41868,
313,
6209,
590,
8512,
481,
2091,
253,
427,
4161,
2601,
22294,
281,
253,
427,
3125,
44,
18,
6437,
13,
6298,
403,
12573,
3304,
253,
894,
326,
2028,
253,
894,
281,
1756,
285,
10957,
13,
285,
326,
1361,
352,
11883,
15,
15601,
569,
275,
253,
427,
3125,
44,
18,
3320,
1421,
281,
247,
2601,
326,
2550,
13185,
6298,
15,
12414,
253,
1463,
7601,
13,
8512,
3150,
407,
247,
1232,
273,
1881,
14,
10812,
2705,
1925,
10596,
15,
28622,
273,
17872,
8512,
5644,
281,
253,
19297,
281,
1928,
3075,
275,
952,
342,
330,
3123,
34,
15,
496,
1635,
13,
952,
342,
330,
3123,
34,
7168,
253,
22614,
4283,
281,
616,
17052,
29108,
13,
534,
5997,
253,
271,
73,
301,
11503,
2326,
275,
5876,
4292,
15
] |
How many people are affected by Dandy-Walker malformation ? | Dandy-Walker malformation is estimated to affect 1 in 10,000 to 30,000 newborns. | [
2347,
1142,
952,
403,
5876,
407,
399,
13183,
14,
46949,
4691,
1248,
3736,
37,
13183,
14,
46949,
4691,
1248,
310,
5998,
281,
2818,
337,
275,
884,
13,
933,
281,
1884,
13,
933,
48842,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
2347,
1142,
952,
403,
5876,
407,
399,
13183,
14,
46949,
4691,
1248,
3736,
37,
13183,
14,
46949,
4691,
1248,
310,
5998,
281,
2818,
337,
275,
884,
13,
933,
281,
1884,
13,
933,
48842,
15
] |
What are the symptoms of Osteoarthritis ? | Pain and Stiffness in Joints Different types of arthritis have different symptoms. In general, people with most forms of arthritis have pain and stiffness in their joints. Osteoarthritis usually develops slowly and can occur in any joint, but often occurs in weight-bearing joints. Early in the disease, joints may ache after physical work or exercise. Most often, osteoarthritis occurs in the hands, hips, knees, neck, or low back. Common Signs Common signs of osteoarthritis include - joint pain, swelling, and tenderness - stiffness after getting out of bed - a crunching feeling or sound of bone rubbing on bone. joint pain, swelling, and tenderness stiffness after getting out of bed a crunching feeling or sound of bone rubbing on bone. Not everyone with osteoarthritis feels pain, however. In fact, only a third of people with x-ray evidence of osteoarthritis report pain or other symptoms. Diagnosis To make a diagnosis of osteoarthritis, most doctors use a combination of methods and tests including a medical history, a physical examination, x-rays, and laboratory tests. - A medical history is the patient's description of symptoms and when and how they began. The description covers pain, stiffness, and joint function, and how these have changed over time. - A physical examination includes the doctor's examination of the joints, skin, reflexes, and muscle strength. The doctor observes the patient's ability to walk, bend, and carry out activities of daily living. - X-rays are limited in their capacity to reveal how much joint damage may have occurred in osteoarthritis. X-rays usually don't show osteoarthritis damage until there has been a significant loss of cartilage. A medical history is the patient's description of symptoms and when and how they began. The description covers pain, stiffness, and joint function, and how these have changed over time. A physical examination includes the doctor's examination of the joints, skin, reflexes, and muscle strength. The doctor observes the patient's ability to walk, bend, and carry out activities of daily living. X-rays are limited in their capacity to reveal how much joint damage may have occurred in osteoarthritis. X-rays usually don't show osteoarthritis damage until there has been a significant loss of cartilage. Questions Your Doctor May Ask It is important for people with joint pain to give the doctor a complete medical history. Answering these questions will help your doctor make an accurate diagnosis: - Is the pain in one or more joints? - When does the pain occur and how long does it last? - When did you first notice the pain? - Does activity make the pain better or worse? - Have you had any illnesses or accidents that may account for the pain? - Is there a family history of any arthritis or rheumatic diseases? - What medicines are you taking? Is the pain in one or more joints? When does the pain occur and how long does it last? When did you first notice the pain? Does activity make the pain better or worse? Have you had any illnesses or accidents that may account for the pain? Is there a family history of any arthritis or rheumatic diseases? What medicines are you taking? A patient's attitudes, daily activities, and levels of anxiety or depression have a lot to do with how severe the symptoms of osteoarthritis may be. Who Can Provide Care Treating arthritis often requires a multidisciplinary or team approach. Many types of health professionals care for people with arthritis. You may choose a few or more of the following professionals to be part of your health care team. - Primary care physicians -- doctors who treat patients before they are referred to other specialists in the health care system. Often a primary care physician will be the main doctor to treat your arthritis. Primary care physicians also handle other medical problems and coordinate the care you receive from other physicians and health care providers. Primary care physicians -- doctors who treat patients before they are referred to other specialists in the health care system. Often a primary care physician will be the main doctor to treat your arthritis. Primary care physicians also handle other medical problems and coordinate the care you receive from other physicians and health care providers. - Rheumatologists -- doctors who specialize in treating arthritis and related conditions that affect joints, muscles, and bones. Rheumatologists -- doctors who specialize in treating arthritis and related conditions that affect joints, muscles, and bones. - Orthopaedists -- surgeons who specialize in the treatment of, and surgery for, bone and joint diseases. Orthopaedists -- surgeons who specialize in the treatment of, and surgery for, bone and joint diseases. - Physical therapists -- health professionals who work with patients to improve joint function. Physical therapists -- health professionals who work with patients to improve joint function. - Occupational therapists -- health professionals who teach ways to protect joints, minimize pain, perform activities of daily living, and conserve energy. Occupational therapists -- health professionals who teach ways to protect joints, minimize pain, perform activities of daily living, and conserve energy. - Dietitians -- health professionals who teach ways to use a good diet to improve health and maintain a healthy weight. Dietitians -- health professionals who teach ways to use a good diet to improve health and maintain a healthy weight. - Nurse educators -- nurses who specialize in helping patients understand their overall condition and implement their treatment plans. Nurse educators -- nurses who specialize in helping patients understand their overall condition and implement their treatment plans. - Physiatrists (rehabilitation specialists) -- medical doctors who help patients make the most of their physical potential. Physiatrists (rehabilitation specialists) -- medical doctors who help patients make the most of their physical potential. - Licensed acupuncture therapists -- health professionals who reduce pain and improve physical functioning by inserting fine needles into the skin at specific points on the body. Licensed acupuncture therapists -- health professionals who reduce pain and improve physical functioning by inserting fine needles into the skin at specific points on the body. - Psychologists -- health professionals who seek to help patients cope with difficulties in the home and workplace resulting from their medical conditions. Psychologists -- health professionals who seek to help patients cope with difficulties in the home and workplace resulting from their medical conditions. - Social workers -- professionals who assist patients with social challenges caused by disability, unemployment, financial hardships, home health care, and other needs resulting from their medical conditions. Social workers -- professionals who assist patients with social challenges caused by disability, unemployment, financial hardships, home health care, and other needs resulting from their medical conditions. - Chiropractors -- health professionals who focus treatment on the relationship between the body's structure -- mainly the spine -- and its functioning. Chiropractors -- health professionals who focus treatment on the relationship between the body's structure -- mainly the spine -- and its functioning. - Massage therapists -- health professionals who press, rub, and otherwise manipulate the muscles and other soft tissues of the body. They most often use their hands and fingers, but may use their forearms, elbows, or feet. Massage therapists -- health professionals who press, rub, and otherwise manipulate the muscles and other soft tissues of the body. They most often use their hands and fingers, but may use their forearms, elbows, or feet. | [
1276,
403,
253,
5917,
273,
49000,
44483,
3736,
42728,
285,
659,
1648,
1255,
275,
23106,
84,
13773,
3510,
273,
21781,
452,
1027,
5917,
15,
496,
2087,
13,
952,
342,
954,
4948,
273,
21781,
452,
3075,
285,
26370,
275,
616,
22136,
15,
49000,
44483,
3798,
24357,
7808,
285,
476,
2826,
275,
667,
6036,
13,
533,
2223,
6634,
275,
2801,
14,
26201,
22136,
15,
15643,
275,
253,
2728,
13,
22136,
778,
49652,
846,
3520,
789,
390,
5763,
15,
5595,
2223,
13,
10160,
44483,
6634,
275,
253,
3564,
13,
29434,
13,
15746,
13,
7623,
13,
390,
1698,
896,
15,
10200,
8714,
84,
10200,
7871,
273,
10160,
44483,
2486,
428,
6036,
3075,
13,
25567,
13,
285,
45620,
50276,
14,
26370,
846,
2970,
562,
273,
3722,
50276,
14,
247,
35178,
272,
5471,
390,
3590,
273,
5961,
35770,
327,
5961,
15,
6036,
3075,
13,
25567,
13,
285,
45620,
26370,
846,
2970,
562,
273,
3722,
247,
35178,
272,
5471,
390,
3590,
273,
5961,
35770,
327,
5961,
15,
3105,
4130,
342,
10160,
44483,
9193,
3075,
13,
2299,
15,
496,
958,
13,
760,
247,
2626,
273,
952,
342,
1269,
14,
1402,
1941,
273,
10160,
44483,
1304,
3075,
390,
643,
5917,
15,
48854,
1916,
1056,
247,
6120,
273,
10160,
44483,
13,
954,
11576,
897,
247,
5019,
273,
3082,
285,
5216,
1690,
247,
3739,
2892,
13,
247,
3520,
8368,
13,
1269,
14,
20237,
13,
285,
9965,
5216,
15,
428,
329,
3739,
2892,
310,
253,
3110,
434,
5740,
273,
5917,
285,
672,
285,
849,
597,
3407,
15,
380,
5740,
10949,
3075,
13,
26370,
13,
285,
6036,
1159,
13,
285,
849,
841,
452,
4391,
689,
673,
15,
50275,
14,
329,
3520,
8368,
3797,
253,
7345,
434,
8368,
273,
253,
22136,
13,
4808,
13,
22375,
265,
13,
285,
6616,
4757,
15,
380,
7345,
40687,
253,
3110,
434,
3745,
281,
2940,
13,
23104,
13,
285,
4459,
562,
4712,
273,
5312,
3811,
15,
50276,
14,
1594,
14,
20237,
403,
3710,
275,
616,
5350,
281,
10313,
849,
1199,
6036,
4723,
778,
452,
5866,
275,
10160,
44483,
15,
1594,
14,
20237,
3798,
1053,
626,
921,
10160,
44483,
4723,
1919,
627,
556,
644,
247,
1534,
2957,
273,
25548,
15,
50276,
34,
3739,
2892,
310,
253,
3110,
434,
5740,
273,
5917,
285,
672,
285,
849,
597,
3407,
15,
380,
5740,
10949,
3075,
13,
26370,
13,
285,
6036,
1159,
13,
285,
849,
841,
452,
4391,
689,
673,
15,
329,
3520,
8368,
3797,
253,
7345,
434,
8368,
273,
253,
22136,
13,
4808,
13,
22375,
265,
13,
285,
6616,
4757,
15,
380,
7345,
40687,
253,
3110,
434,
3745,
281,
2940,
13,
23104,
13,
285,
4459,
562,
4712,
273,
5312,
3811,
15,
1594,
14,
20237,
403,
3710,
275,
616,
5350,
281,
10313,
849,
1199,
6036,
4723,
778,
452,
5866,
275,
10160,
44483,
15,
1594,
14,
20237,
3798,
1053,
626,
921,
10160,
44483,
4723,
1919,
627,
556,
644,
247,
1534,
2957,
273,
25548,
15,
30254,
5402,
15058,
2552,
26659,
733,
310,
1774,
323,
952,
342,
6036,
3075,
281,
1918,
253,
7345,
247,
3426,
3739,
2892,
15,
743,
2140,
2158,
841,
3533,
588,
1361,
634,
7345,
1056,
271,
7899,
6120,
27,
428,
1680,
253,
3075,
275,
581,
390,
625,
22136,
32,
50276,
14,
2091,
1057,
253,
3075,
2826,
285,
849,
1048,
1057,
352,
1390,
32,
50276,
14,
2091,
858,
368,
806,
4366,
253,
3075,
32,
50276,
14,
9876,
2425,
1056,
253,
3075,
1805,
390,
7197,
32,
50276,
14,
12238,
368,
574,
667,
31372,
390,
23678,
326,
778,
2395,
323,
253,
3075,
32,
50276,
14,
1680,
627,
247,
2021,
2892,
273,
667,
21781,
390,
23404,
18266,
6578,
32,
50276,
14,
1737,
26114,
403,
368,
3192,
32,
1680,
253,
3075,
275,
581,
390,
625,
22136,
32,
2091,
1057,
253,
3075,
2826,
285,
849,
1048,
1057,
352,
1390,
32,
2091,
858,
368,
806,
4366,
253,
3075,
32,
9876,
2425,
1056,
253,
3075,
1805,
390,
7197,
32,
12238,
368,
574,
667,
31372,
390,
23678,
326,
778,
2395,
323,
253,
3075,
32,
1680,
627,
247,
2021,
2892,
273,
667,
21781,
390,
23404,
18266,
6578,
32,
1737,
26114,
403,
368,
3192,
32,
329,
3110,
434,
18222,
13,
5312,
4712,
13,
285,
2308,
273,
10397,
390,
9454,
452,
247,
2257,
281,
513,
342,
849,
5460,
253,
5917,
273,
10160,
44483,
778,
320,
15,
8452,
2615,
9225,
504,
9776,
21560,
272,
21781,
2223,
4419,
247,
44656,
390,
2285,
2746,
15,
6676,
3510,
273,
1786,
12440,
1557,
323,
952,
342,
21781,
15,
1422,
778,
5206,
247,
1643,
390,
625,
273,
253,
1563,
12440,
281,
320,
629,
273,
634,
1786,
1557,
2285,
15,
428,
20988,
1557,
14975,
1969,
11576,
665,
1555,
1363,
1078,
597,
403,
6289,
281,
643,
27371,
275,
253,
1786,
1557,
985,
15,
24503,
247,
3625,
1557,
12878,
588,
320,
253,
2022,
7345,
281,
1555,
634,
21781,
15,
20988,
1557,
14975,
671,
6016,
643,
3739,
3237,
285,
13249,
253,
1557,
368,
4763,
432,
643,
14975,
285,
1786,
1557,
11967,
15,
20988,
1557,
14975,
1969,
11576,
665,
1555,
1363,
1078,
597,
403,
6289,
281,
643,
27371,
275,
253,
1786,
1557,
985,
15,
24503,
247,
3625,
1557,
12878,
588,
320,
253,
2022,
7345,
281,
1555,
634,
21781,
15,
20988,
1557,
14975,
671,
6016,
643,
3739,
3237,
285,
13249,
253,
1557,
368,
4763,
432,
643,
14975,
285,
1786,
1557,
11967,
15,
428,
40334,
21154,
11644,
50276,
283,
11576,
665,
2714,
907,
275,
12767,
21781,
285,
2905,
2515,
326,
2818,
22136,
13,
13370,
13,
285,
14910,
15,
40334,
21154,
11644,
50276,
283,
11576,
665,
2714,
907,
275,
12767,
21781,
285,
2905,
2515,
326,
2818,
22136,
13,
13370,
13,
285,
14910,
15,
428,
20268,
20414,
264,
1346,
50276,
283,
30208,
665,
2714,
907,
275,
253,
1971,
273,
13,
285,
5869,
323,
13,
5961,
285,
6036,
6578,
15,
20268,
20414,
264,
1346,
50276,
283,
30208,
665,
2714,
907,
275,
253,
1971,
273,
13,
285,
5869,
323,
13,
5961,
285,
6036,
6578,
15,
428,
22606,
44880,
50276,
283,
1786,
12440,
665,
789,
342,
1363,
281,
3157,
6036,
1159,
15,
22606,
44880,
50276,
283,
1786,
12440,
665,
789,
342,
1363,
281,
3157,
6036,
1159,
15,
428,
29314,
1050,
44880,
50276,
283,
1786,
12440,
665,
9798,
4088,
281,
4017,
22136,
13,
15338,
3075,
13,
1347,
4712,
273,
5312,
3811,
13,
285,
772,
4003,
2341,
15,
29314,
1050,
44880,
50276,
283,
1786,
12440,
665,
9798,
4088,
281,
4017,
22136,
13,
15338,
3075,
13,
1347,
4712,
273,
5312,
3811,
13,
285,
772,
4003,
2341,
15,
428,
23845,
262,
2458,
1969,
1786,
12440,
665,
9798,
4088,
281,
897,
247,
1175,
6196,
281,
3157,
1786,
285,
6558,
247,
5875,
2801,
15,
23845,
262,
2458,
1969,
1786,
12440,
665,
9798,
4088,
281,
897,
247,
1175,
6196,
281,
3157,
1786,
285,
6558,
247,
5875,
2801,
15,
428,
47784,
37419,
50276,
283,
16675,
665,
2714,
907,
275,
9073,
1363,
2096,
616,
4583,
1617,
285,
3359,
616,
1971,
5827,
15,
47784,
37419,
50276,
283,
16675,
665,
2714,
907,
275,
9073,
1363,
2096,
616,
4583,
1617,
285,
3359,
616,
1971,
5827,
15,
428,
4111,
5946,
48221,
313,
250,
16626,
27371,
10,
1969,
3739,
11576,
665,
1361,
1363,
1056,
253,
954,
273,
616,
3520,
2442,
15,
50276,
9083,
5946,
48221,
313,
250,
16626,
27371,
10,
1969,
3739,
11576,
665,
1361,
1363,
1056,
253,
954,
273,
616,
3520,
2442,
15,
428,
21737,
42543,
44880,
50276,
283,
1786,
12440,
665,
4796,
3075,
285,
3157,
3520,
15415,
407,
30471,
4030,
32545,
715,
253,
4808,
387,
2173,
2792,
327,
253,
2133,
15,
21737,
42543,
44880,
50276,
283,
1786,
12440,
665,
4796,
3075,
285,
3157,
3520,
15415,
407,
30471,
4030,
32545,
715,
253,
4808,
387,
2173,
2792,
327,
253,
2133,
15,
428,
13219,
11644,
50276,
283,
1786,
12440,
665,
7703,
281,
1361,
1363,
23808,
342,
12748,
275,
253,
1728,
285,
21853,
4795,
432,
616,
3739,
2515,
15,
13219,
11644,
50276,
283,
1786,
12440,
665,
7703,
281,
1361,
1363,
23808,
342,
12748,
275,
253,
1728,
285,
21853,
4795,
432,
616,
3739,
2515,
15,
428,
8404,
5820,
1969,
12440,
665,
10073,
1363,
342,
2675,
7881,
4269,
407,
12564,
13,
20549,
13,
4832,
1892,
19794,
13,
1728,
1786,
1557,
13,
285,
643,
3198,
4795,
432,
616,
3739,
2515,
15,
8404,
5820,
1969,
12440,
665,
10073,
1363,
342,
2675,
7881,
4269,
407,
12564,
13,
20549,
13,
4832,
1892,
19794,
13,
1728,
1786,
1557,
13,
285,
643,
3198,
4795,
432,
616,
3739,
2515,
15,
428,
18907,
1658,
974,
641,
50276,
283,
1786,
12440,
665,
2770,
1971,
327,
253,
2954,
875,
253,
2133,
434,
2605,
1969,
7194,
253,
17201,
1969,
285,
697,
15415,
15,
18907,
1658,
974,
641,
50276,
283,
1786,
12440,
665,
2770,
1971,
327,
253,
2954,
875,
253,
2133,
434,
2605,
1969,
7194,
253,
17201,
1969,
285,
697,
15415,
15,
428,
7532,
486,
44880,
50276,
283,
1786,
12440,
665,
2315,
13,
7692,
13,
285,
5010,
26526,
253,
13370,
285,
643,
2602,
7944,
273,
253,
2133,
15,
1583,
954,
2223,
897,
616,
3564,
285,
9881,
13,
533,
778,
897,
616,
2273,
15326,
13,
46387,
13,
390,
4669,
15,
7532,
486,
44880,
50276,
283,
1786,
12440,
665,
2315,
13,
7692,
13,
285,
5010,
26526,
253,
13370,
285,
643,
2602,
7944,
273,
253,
2133,
15,
1583,
954,
2223,
897,
616,
3564,
285,
9881,
13,
533,
778,
897,
616,
2273,
15326,
13,
46387,
13,
390,
4669,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
403,
253,
5917,
273,
49000,
44483,
3736,
42728,
285,
659,
1648,
1255,
275,
23106,
84,
13773,
3510,
273,
21781,
452,
1027,
5917,
15,
496,
2087,
13,
952,
342,
954,
4948,
273,
21781,
452,
3075,
285,
26370,
275,
616,
22136,
15,
49000,
44483,
3798,
24357,
7808,
285,
476,
2826,
275,
667,
6036,
13,
533,
2223,
6634,
275,
2801,
14,
26201,
22136,
15,
15643,
275,
253,
2728,
13,
22136,
778,
49652,
846,
3520,
789,
390,
5763,
15,
5595,
2223,
13,
10160,
44483,
6634,
275,
253,
3564,
13,
29434,
13,
15746,
13,
7623,
13,
390,
1698,
896,
15,
10200,
8714,
84,
10200,
7871,
273,
10160,
44483,
2486,
428,
6036,
3075,
13,
25567,
13,
285,
45620,
50276,
14,
26370,
846,
2970,
562,
273,
3722,
50276,
14,
247,
35178,
272,
5471,
390,
3590,
273,
5961,
35770,
327,
5961,
15,
6036,
3075,
13,
25567,
13,
285,
45620,
26370,
846,
2970,
562,
273,
3722,
247,
35178,
272,
5471,
390,
3590,
273,
5961,
35770,
327,
5961,
15,
3105,
4130,
342,
10160,
44483,
9193,
3075,
13,
2299,
15,
496,
958,
13,
760,
247,
2626,
273,
952,
342,
1269,
14,
1402,
1941,
273,
10160,
44483,
1304,
3075,
390,
643,
5917,
15,
48854,
1916,
1056,
247,
6120,
273,
10160,
44483,
13,
954,
11576,
897,
247,
5019,
273,
3082,
285,
5216,
1690,
247,
3739,
2892,
13,
247,
3520,
8368,
13,
1269,
14,
20237,
13,
285,
9965,
5216,
15,
428,
329,
3739,
2892,
310,
253,
3110,
434,
5740,
273,
5917,
285,
672,
285,
849,
597,
3407,
15,
380,
5740,
10949,
3075,
13,
26370,
13,
285,
6036,
1159,
13,
285,
849,
841,
452,
4391,
689,
673,
15,
50275,
14,
329,
3520,
8368,
3797,
253,
7345,
434,
8368,
273,
253,
22136,
13,
4808,
13,
22375,
265,
13,
285,
6616,
4757,
15,
380,
7345,
40687,
253,
3110,
434,
3745,
281,
2940,
13,
23104,
13,
285,
4459,
562,
4712,
273,
5312,
3811,
15,
50276,
14,
1594,
14,
20237,
403,
3710,
275,
616,
5350,
281,
10313,
849,
1199,
6036,
4723,
778,
452,
5866,
275,
10160,
44483,
15,
1594,
14,
20237,
3798,
1053,
626,
921,
10160,
44483,
4723,
1919,
627,
556,
644,
247,
1534,
2957,
273,
25548,
15,
50276,
34,
3739,
2892,
310,
253,
3110,
434,
5740,
273,
5917,
285,
672,
285,
849,
597,
3407,
15,
380,
5740,
10949,
3075,
13,
26370,
13,
285,
6036,
1159,
13,
285,
849,
841,
452,
4391,
689,
673,
15,
329,
3520,
8368,
3797,
253,
7345,
434,
8368,
273,
253,
22136,
13,
4808,
13,
22375,
265,
13,
285,
6616,
4757,
15,
380,
7345,
40687,
253,
3110,
434,
3745,
281,
2940,
13,
23104,
13,
285,
4459,
562,
4712,
273,
5312,
3811,
15,
1594,
14,
20237,
403,
3710,
275,
616,
5350,
281,
10313,
849,
1199,
6036,
4723,
778,
452,
5866,
275,
10160,
44483,
15,
1594,
14,
20237,
3798,
1053,
626,
921,
10160,
44483,
4723,
1919,
627,
556,
644,
247,
1534,
2957,
273,
25548,
15,
30254,
5402,
15058,
2552,
26659,
733,
310,
1774,
323,
952,
342,
6036,
3075,
281,
1918,
253,
7345,
247,
3426,
3739,
2892,
15,
743,
2140,
2158,
841,
3533,
588,
1361,
634,
7345,
1056,
271,
7899,
6120,
27,
428,
1680,
253,
3075,
275,
581,
390,
625,
22136,
32,
50276,
14,
2091,
1057,
253,
3075,
2826,
285,
849,
1048,
1057,
352,
1390,
32,
50276,
14,
2091,
858,
368,
806,
4366,
253,
3075,
32,
50276,
14,
9876,
2425,
1056,
253,
3075,
1805,
390,
7197,
32,
50276,
14,
12238,
368,
574,
667,
31372,
390,
23678,
326,
778,
2395,
323,
253,
3075,
32,
50276,
14,
1680,
627,
247,
2021,
2892,
273,
667,
21781,
390,
23404,
18266,
6578,
32,
50276,
14,
1737,
26114,
403,
368,
3192,
32,
1680,
253,
3075,
275,
581,
390,
625,
22136,
32,
2091,
1057,
253,
3075,
2826,
285,
849,
1048,
1057,
352,
1390,
32,
2091,
858,
368,
806,
4366,
253,
3075,
32,
9876,
2425,
1056,
253,
3075,
1805,
390,
7197,
32,
12238,
368,
574,
667,
31372,
390,
23678,
326,
778,
2395,
323,
253,
3075,
32,
1680,
627,
247,
2021,
2892,
273,
667,
21781,
390,
23404,
18266,
6578,
32,
1737,
26114,
403,
368,
3192,
32,
329,
3110,
434,
18222,
13,
5312,
4712,
13,
285,
2308,
273,
10397,
390,
9454,
452,
247,
2257,
281,
513,
342,
849,
5460,
253,
5917,
273,
10160,
44483,
778,
320,
15,
8452,
2615,
9225,
504,
9776,
21560,
272,
21781,
2223,
4419,
247,
44656,
390,
2285,
2746,
15,
6676,
3510,
273,
1786,
12440,
1557,
323,
952,
342,
21781,
15,
1422,
778,
5206,
247,
1643,
390,
625,
273,
253,
1563,
12440,
281,
320,
629,
273,
634,
1786,
1557,
2285,
15,
428,
20988,
1557,
14975,
1969,
11576,
665,
1555,
1363,
1078,
597,
403,
6289,
281,
643,
27371,
275,
253,
1786,
1557,
985,
15,
24503,
247,
3625,
1557,
12878,
588,
320,
253,
2022,
7345,
281,
1555,
634,
21781,
15,
20988,
1557,
14975,
671,
6016,
643,
3739,
3237,
285,
13249,
253,
1557,
368,
4763,
432,
643,
14975,
285,
1786,
1557,
11967,
15,
20988,
1557,
14975,
1969,
11576,
665,
1555,
1363,
1078,
597,
403,
6289,
281,
643,
27371,
275,
253,
1786,
1557,
985,
15,
24503,
247,
3625,
1557,
12878,
588,
320,
253,
2022,
7345,
281,
1555,
634,
21781,
15,
20988,
1557,
14975,
671,
6016,
643,
3739,
3237,
285,
13249,
253,
1557,
368,
4763,
432,
643,
14975,
285,
1786,
1557,
11967,
15,
428,
40334,
21154,
11644,
50276,
283,
11576,
665,
2714,
907,
275,
12767,
21781,
285,
2905,
2515,
326,
2818,
22136,
13,
13370,
13,
285,
14910,
15,
40334,
21154,
11644,
50276,
283,
11576,
665,
2714,
907,
275,
12767,
21781,
285,
2905,
2515,
326,
2818,
22136,
13,
13370,
13,
285,
14910,
15,
428,
20268,
20414,
264,
1346,
50276,
283,
30208,
665,
2714,
907,
275,
253,
1971,
273,
13,
285,
5869,
323,
13,
5961,
285,
6036,
6578,
15,
20268,
20414,
264,
1346,
50276,
283,
30208,
665,
2714,
907,
275,
253,
1971,
273,
13,
285,
5869,
323,
13,
5961,
285,
6036,
6578,
15,
428,
22606,
44880,
50276,
283,
1786,
12440,
665,
789,
342,
1363,
281,
3157,
6036,
1159,
15,
22606,
44880,
50276,
283,
1786,
12440,
665,
789,
342,
1363,
281,
3157,
6036,
1159,
15,
428,
29314,
1050,
44880,
50276,
283,
1786,
12440,
665,
9798,
4088,
281,
4017,
22136,
13,
15338,
3075,
13,
1347,
4712,
273,
5312,
3811,
13,
285,
772,
4003,
2341,
15,
29314,
1050,
44880,
50276,
283,
1786,
12440,
665,
9798,
4088,
281,
4017,
22136,
13,
15338,
3075,
13,
1347,
4712,
273,
5312,
3811,
13,
285,
772,
4003,
2341,
15,
428,
23845,
262,
2458,
1969,
1786,
12440,
665,
9798,
4088,
281,
897,
247,
1175,
6196,
281,
3157,
1786,
285,
6558,
247,
5875,
2801,
15,
23845,
262,
2458,
1969,
1786,
12440,
665,
9798,
4088,
281,
897,
247,
1175,
6196,
281,
3157,
1786,
285,
6558,
247,
5875,
2801,
15,
428,
47784,
37419,
50276,
283,
16675,
665,
2714,
907,
275,
9073,
1363,
2096,
616,
4583,
1617,
285,
3359,
616,
1971,
5827,
15,
47784,
37419,
50276,
283,
16675,
665,
2714,
907,
275,
9073,
1363,
2096,
616,
4583,
1617,
285,
3359,
616,
1971,
5827,
15,
428,
4111,
5946,
48221,
313,
250,
16626,
27371,
10,
1969,
3739,
11576,
665,
1361,
1363,
1056,
253,
954,
273,
616,
3520,
2442,
15,
50276,
9083,
5946,
48221,
313,
250,
16626,
27371,
10,
1969,
3739,
11576,
665,
1361,
1363,
1056,
253,
954,
273,
616,
3520,
2442,
15,
428,
21737,
42543,
44880,
50276,
283,
1786,
12440,
665,
4796,
3075,
285,
3157,
3520,
15415,
407,
30471,
4030,
32545,
715,
253,
4808,
387,
2173,
2792,
327,
253,
2133,
15,
21737,
42543,
44880,
50276,
283,
1786,
12440,
665,
4796,
3075,
285,
3157,
3520,
15415,
407,
30471,
4030,
32545,
715,
253,
4808,
387,
2173,
2792,
327,
253,
2133,
15,
428,
13219,
11644,
50276,
283,
1786,
12440,
665,
7703,
281,
1361,
1363,
23808,
342,
12748,
275,
253,
1728,
285,
21853,
4795,
432,
616,
3739,
2515,
15,
13219,
11644,
50276,
283,
1786,
12440,
665,
7703,
281,
1361,
1363,
23808,
342,
12748,
275,
253,
1728,
285,
21853,
4795,
432,
616,
3739,
2515,
15,
428,
8404,
5820,
1969,
12440,
665,
10073,
1363,
342,
2675,
7881,
4269,
407,
12564,
13,
20549,
13,
4832,
1892,
19794,
13,
1728,
1786,
1557,
13,
285,
643,
3198,
4795,
432,
616,
3739,
2515,
15,
8404,
5820,
1969,
12440,
665,
10073,
1363,
342,
2675,
7881,
4269,
407,
12564,
13,
20549,
13,
4832,
1892,
19794,
13,
1728,
1786,
1557,
13,
285,
643,
3198,
4795,
432,
616,
3739,
2515,
15,
428,
18907,
1658,
974,
641,
50276,
283,
1786,
12440,
665,
2770,
1971,
327,
253,
2954,
875,
253,
2133,
434,
2605,
1969,
7194,
253,
17201,
1969,
285,
697,
15415,
15,
18907,
1658,
974,
641,
50276,
283,
1786,
12440,
665,
2770,
1971,
327,
253,
2954,
875,
253,
2133,
434,
2605,
1969,
7194,
253,
17201,
1969,
285,
697,
15415,
15,
428,
7532,
486,
44880,
50276,
283,
1786,
12440,
665,
2315,
13,
7692,
13,
285,
5010,
26526,
253,
13370,
285,
643,
2602,
7944,
273,
253,
2133,
15,
1583,
954,
2223,
897,
616,
3564,
285,
9881,
13,
533,
778,
897,
616,
2273,
15326,
13,
46387,
13,
390,
4669,
15,
7532,
486,
44880,
50276,
283,
1786,
12440,
665,
2315,
13,
7692,
13,
285,
5010,
26526,
253,
13370,
285,
643,
2602,
7944,
273,
253,
2133,
15,
1583,
954,
2223,
897,
616,
3564,
285,
9881,
13,
533,
778,
897,
616,
2273,
15326,
13,
46387,
13,
390,
4669,
15
] |
What are the treatments for Acromegaly ? | Currently, treatment options include surgical removal of the tumor, medical therapy, and radiation therapy of the pituitary.
Goals of treatment are to
- reduce excess hormone production to normal levels - relieve the pressure that the growing pituitary tumor may be exerting on the surrounding brain areas - preserve normal pituitary function or treat hormone deficiencies - improve the symptoms of acromegaly
Surgery
Surgery is the first option recommended for most people with acromegaly, as it is often a rapid and effective treatment. The surgeon reaches the pituitary via an incision through the nose or inside the upper lip and, with special tools, removes the tumor tissue in a procedure called transsphenoidal surgery. This procedure promptly relieves the pressure on the surrounding brain regions and leads to a rapid lowering of GH levels. If the surgery is successful, facial appearance and soft tissue swelling improve within a few days.
Surgery is most successful in patients with blood GH levels below 45 ng/ml before the operation and with pituitary tumors no larger than 10 millimeters (mm) in diameter. Success depends in large part on the skill and experience of the surgeon, as well as the location of the tumor. Even with the most experienced neurosurgeon, the chance of a cure is small if the tumor has extended into critical brain structures or into the cavernous sinus where surgery could be risky.
The success rate also depends on what level of GH is defined as a cure. The best measure of surgical success is normalization of GH and IGF-I levels. The overall rate of remission-control of the disease-after surgery ranges from 55 to 80 percent. (See For More Information to locate a board-certified neurosurgeon.)
A possible complication of surgery is damage to the surrounding normal pituitary tissue, which requires lifelong use of pituitary hormone replacement. The part of the pituitary that stores antidiuretic hormonea hormone important in water balancemay be temporarily or, rarely, permanently damaged and the patient may require medical therapy. Other potential problems include cerebrospinal fluid leaks and, rarely, meningitis. Cerebrospinal fluid bathes the brain and can leak from the nose if the incision area doesnt heal well. Meningitis is a bacterial or viral infection of the meninges, the outer covering of the brain.
Even when surgery is successful and hormone levels return to normal, people with acromegaly must be carefully monitored for years for possible recurrence of the disease. More commonly, hormone levels improve, but do not return to normal. Additional treatment, usually medications, may be required.
Medical Therapy
Medical therapy is most often used if surgery does not result in a cure and sometimes to shrink large tumors before surgery. Three medication groups are used to treat acromegaly.
Somatostatin analogs (SSAs) are the first medication group used to treat acromegaly. They shut off GH production and are effective in lowering GH and IGF-I levels in 50 to 70 percent of patients. SSAs also reduce tumor size in around 0 to 50 percent of patients but only to a modest degree. Several studies have shown that SSAs are safe and effective for long-term treatment and in treating patients with acromegaly caused by nonpituitary tumors. Long-acting SSAs are given by intramuscular injection once a month.
Digestive problems-such as loose stools, nausea, and gas-are a side effect in about half of people taking SSAs. However, the effects are usually temporary and rarely severe. About 10 to 20 percent of patients develop gallstones, but the gallstones do not usually cause symptoms. In rare cases, treatment can result in elevated blood glucose levels. More commonly, SSAs reduce the need for insulin and improve blood glucose control in some people with acromegaly who already have diabetes.
The second medication group is the GH receptor antagonists (GHRAs), which interfere with the action of GH. They normalize IGF-I levels in more than 90 percent of patients. They do not, however, lower GH levels. Given once a day through injection, GHRAs are usually well-tolerated by patients. The long-term effects of these drugs on tumor growth are still under study. Side effects can include headaches, fatigue, and abnormal liver function.
Dopamine agonists make up the third medication group. These drugs are not as effective as the other medications at lowering GH or IGF-I levels, and they normalize IGF-I levels in only a minority of patients. Dopamine agonists are sometimes effective in patients who have mild degrees of excess GH and have both acromegaly and hyperprolactinemiatoo much of the hormone prolactin. Dopamine agonists can be used in combination with SSAs. Side effects can include nausea, headache, and lightheadedness.
Agonist: A drug that binds to a receptor of a cell and triggers a response by the cell, mimicking the action of a naturally occurring substance. Antagonist: A chemical that acts within the body to reduce the physiological activity of another chemical substance or hormone.
Radiation Therapy
Radiation therapy is usually reserved for people who have some tumor remaining after surgery and do not respond to medications. Because radiation leads to a slow lowering of GH and IGF-I levels, these patients often also receive medication to lower hormone levels. The full effect of this therapy may not occur for many years.
The two types of radiation delivery are conventional and stereotactic. Conventional radiation delivery targets the tumor with external beams but can damage surrounding tissue. The treatment delivers small doses of radiation multiple times over 4 to 6 weeks, giving normal tissue time to heal between treatments.
Stereotactic delivery allows precise targeting of a high-dose beam of radiation at the tumor from varying angles. The patient must wear a rigid head frame to keep the head still. The types of stereotactic radiation delivery currently available are proton beam, linear accelerator (LINAC), and gamma knife. With stereotactic delivery, the tumor must be at least 5 mm from the optic chiasm to prevent radiation damage. This treatment can sometimes be done in a single session, reducing the risk of damage to surrounding tissue.
All forms of radiation therapy cause a gradual decline in production of other pituitary hormones over time, resulting in the need for hormone replacement in most patients. Radiation also can impair a patients fertility. Vision loss and brain injury are rare complications. Rarely, secondary tumors can develop many years later in areas that were in the path of the radiation beam. | [
1276,
403,
253,
9694,
323,
5192,
409,
909,
5242,
3736,
26747,
13,
1971,
4610,
2486,
9205,
8570,
273,
253,
4502,
13,
3739,
4918,
13,
285,
7742,
4918,
273,
253,
37804,
15,
187,
50262,
187,
6826,
932,
273,
1971,
403,
281,
187,
50262,
187,
14,
4796,
6714,
14689,
3275,
281,
2622,
2308,
50276,
14,
29522,
253,
3473,
326,
253,
5675,
37804,
4502,
778,
320,
14227,
272,
327,
253,
8704,
3998,
3672,
50276,
14,
14003,
2622,
37804,
1159,
390,
1555,
14689,
30218,
50276,
14,
3157,
253,
5917,
273,
913,
409,
909,
5242,
187,
50262,
187,
14102,
5158,
187,
50262,
187,
14102,
5158,
310,
253,
806,
4500,
8521,
323,
954,
952,
342,
913,
409,
909,
5242,
13,
347,
352,
310,
2223,
247,
5233,
285,
3576,
1971,
15,
380,
20997,
14190,
253,
37804,
3066,
271,
33708,
949,
253,
11480,
390,
3304,
253,
5170,
5541,
285,
13,
342,
2714,
5657,
13,
26586,
253,
4502,
4408,
275,
247,
5199,
1925,
811,
1033,
864,
16080,
5869,
15,
831,
5199,
25122,
18604,
1634,
253,
3473,
327,
253,
8704,
3998,
4811,
285,
5644,
281,
247,
5233,
23345,
273,
22419,
2308,
15,
1310,
253,
5869,
310,
5547,
13,
17754,
7286,
285,
2602,
4408,
25567,
3157,
1561,
247,
1643,
1897,
15,
187,
50262,
187,
14102,
5158,
310,
954,
5547,
275,
1363,
342,
2614,
22419,
2308,
2708,
5329,
9782,
16,
1686,
1078,
253,
4254,
285,
342,
37804,
8837,
642,
4067,
685,
884,
5499,
29399,
313,
2188,
10,
275,
9080,
15,
22764,
7024,
275,
1781,
629,
327,
253,
10861,
285,
2793,
273,
253,
20997,
13,
347,
973,
347,
253,
4328,
273,
253,
4502,
15,
4952,
342,
253,
954,
7407,
6551,
9960,
32719,
13,
253,
4839,
273,
247,
16498,
310,
1355,
604,
253,
4502,
556,
6508,
715,
4619,
3998,
5289,
390,
715,
253,
46531,
528,
22749,
835,
5869,
812,
320,
29198,
15,
187,
50262,
187,
510,
2323,
2281,
671,
7024,
327,
752,
1268,
273,
22419,
310,
2931,
347,
247,
16498,
15,
380,
1682,
2557,
273,
9205,
2323,
310,
21539,
273,
22419,
285,
23591,
14,
42,
2308,
15,
380,
4583,
2281,
273,
31701,
14,
8519,
273,
253,
2728,
14,
6438,
5869,
13794,
432,
7288,
281,
5096,
2558,
15,
313,
5035,
1198,
3010,
8339,
281,
19912,
247,
4450,
14,
15004,
1245,
6551,
9960,
32719,
2698,
187,
50262,
187,
34,
1896,
23950,
273,
5869,
310,
4723,
281,
253,
8704,
2622,
37804,
4408,
13,
534,
4419,
36536,
897,
273,
37804,
14689,
5407,
15,
380,
629,
273,
253,
37804,
326,
10111,
1331,
13535,
459,
3028,
14689,
66,
14689,
1774,
275,
1824,
6654,
11159,
320,
20220,
390,
13,
11766,
13,
21311,
13572,
285,
253,
3110,
778,
2430,
3739,
4918,
15,
5131,
2442,
3237,
2486,
34879,
45895,
6514,
31693,
285,
13,
11766,
13,
30091,
5895,
15,
330,
11892,
9108,
45895,
6514,
10464,
1041,
253,
3998,
285,
476,
13584,
432,
253,
11480,
604,
253,
33708,
2170,
36908,
20658,
973,
15,
353,
2980,
5895,
310,
247,
10741,
390,
9907,
5066,
273,
253,
30091,
265,
13,
253,
8346,
10985,
273,
253,
3998,
15,
187,
50262,
187,
9586,
672,
5869,
310,
5547,
285,
14689,
2308,
1091,
281,
2622,
13,
952,
342,
913,
409,
909,
5242,
1364,
320,
9257,
16387,
323,
1107,
323,
1896,
15969,
273,
253,
2728,
15,
3010,
7744,
13,
14689,
2308,
3157,
13,
533,
513,
417,
1091,
281,
2622,
15,
14117,
1971,
13,
3798,
16940,
13,
778,
320,
2424,
15,
187,
50262,
187,
41225,
34294,
187,
50262,
187,
41225,
4918,
310,
954,
2223,
908,
604,
5869,
1057,
417,
906,
275,
247,
16498,
285,
4536,
281,
23973,
1781,
8837,
1078,
5869,
15,
9064,
12358,
2390,
403,
908,
281,
1555,
913,
409,
909,
5242,
15,
187,
50262,
187,
52,
16692,
49897,
43121,
313,
3528,
1909,
10,
403,
253,
806,
12358,
1387,
908,
281,
1555,
913,
409,
909,
5242,
15,
1583,
6294,
745,
22419,
3275,
285,
403,
3576,
275,
23345,
22419,
285,
23591,
14,
42,
2308,
275,
2456,
281,
5571,
2558,
273,
1363,
15,
13575,
1909,
671,
4796,
4502,
1979,
275,
1475,
470,
281,
2456,
2558,
273,
1363,
533,
760,
281,
247,
16453,
4248,
15,
12090,
2175,
452,
2011,
326,
13575,
1909,
403,
4999,
285,
3576,
323,
1048,
14,
3945,
1971,
285,
275,
12767,
1363,
342,
913,
409,
909,
5242,
4269,
407,
1327,
18086,
32419,
8837,
15,
8057,
14,
20594,
13575,
1909,
403,
1677,
407,
34626,
35109,
8829,
2378,
247,
1770,
15,
187,
50262,
187,
19224,
383,
422,
3237,
14,
10328,
347,
13155,
331,
23699,
13,
33706,
13,
285,
3678,
14,
609,
247,
1930,
1055,
275,
670,
2716,
273,
952,
3192,
13575,
1909,
15,
1723,
13,
253,
2538,
403,
3798,
11287,
285,
11766,
5460,
15,
11376,
884,
281,
1384,
2558,
273,
1363,
1287,
9391,
35695,
13,
533,
253,
9391,
35695,
513,
417,
3798,
2847,
5917,
15,
496,
7520,
2219,
13,
1971,
476,
906,
275,
10702,
2614,
8383,
2308,
15,
3010,
7744,
13,
13575,
1909,
4796,
253,
878,
323,
9442,
285,
3157,
2614,
8383,
1453,
275,
690,
952,
342,
913,
409,
909,
5242,
665,
2168,
452,
8401,
15,
187,
50262,
187,
510,
1273,
12358,
1387,
310,
253,
22419,
6437,
33226,
313,
40,
9914,
1909,
582,
534,
19323,
342,
253,
2250,
273,
22419,
15,
1583,
39142,
23591,
14,
42,
2308,
275,
625,
685,
5091,
2558,
273,
1363,
15,
1583,
513,
417,
13,
2299,
13,
2406,
22419,
2308,
15,
10300,
2378,
247,
1388,
949,
8829,
13,
443,
9914,
1909,
403,
3798,
973,
14,
34776,
12072,
407,
1363,
15,
380,
1048,
14,
3945,
2538,
273,
841,
5835,
327,
4502,
3116,
403,
1335,
762,
1263,
15,
19942,
2538,
476,
2486,
37403,
13,
18693,
13,
285,
10969,
6728,
1159,
15,
187,
50262,
187,
37,
412,
6771,
36541,
1056,
598,
253,
2626,
12358,
1387,
15,
2053,
5835,
403,
417,
347,
3576,
347,
253,
643,
16940,
387,
23345,
22419,
390,
23591,
14,
42,
2308,
13,
285,
597,
39142,
23591,
14,
42,
2308,
275,
760,
247,
15156,
273,
1363,
15,
399,
412,
6771,
36541,
403,
4536,
3576,
275,
1363,
665,
452,
11134,
7759,
273,
6714,
22419,
285,
452,
1097,
913,
409,
909,
5242,
285,
4373,
856,
77,
20050,
358,
5946,
3288,
1199,
273,
253,
14689,
27400,
20050,
15,
399,
412,
6771,
36541,
476,
320,
908,
275,
5019,
342,
13575,
1909,
15,
19942,
2538,
476,
2486,
33706,
13,
24934,
13,
285,
1708,
24818,
1255,
15,
187,
50262,
187,
8903,
251,
382,
27,
329,
2854,
326,
22294,
281,
247,
6437,
273,
247,
894,
285,
23785,
247,
2380,
407,
253,
894,
13,
13892,
12427,
253,
2250,
273,
247,
10748,
12952,
10359,
15,
50275,
24657,
5154,
382,
27,
329,
5793,
326,
6993,
1561,
253,
2133,
281,
4796,
253,
13424,
2425,
273,
1529,
5793,
10359,
390,
14689,
15,
187,
50262,
187,
13021,
2492,
34294,
187,
50262,
187,
13021,
2492,
4918,
310,
3798,
10827,
323,
952,
665,
452,
690,
4502,
5780,
846,
5869,
285,
513,
417,
3794,
281,
16940,
15,
4923,
7742,
5644,
281,
247,
3468,
23345,
273,
22419,
285,
23591,
14,
42,
2308,
13,
841,
1363,
2223,
671,
4763,
12358,
281,
2406,
14689,
2308,
15,
380,
2120,
1055,
273,
436,
4918,
778,
417,
2826,
323,
1142,
1107,
15,
187,
50262,
187,
510,
767,
3510,
273,
7742,
6742,
403,
6041,
285,
14166,
302,
9994,
15,
44347,
7742,
6742,
8571,
253,
4502,
342,
6024,
20435,
533,
476,
4723,
8704,
4408,
15,
380,
1971,
26361,
1355,
12768,
273,
7742,
2709,
2069,
689,
577,
281,
721,
3618,
13,
4933,
2622,
4408,
673,
281,
20658,
875,
9694,
15,
187,
50262,
187,
6812,
250,
302,
9994,
6742,
4483,
10799,
12262,
273,
247,
1029,
14,
19572,
8325,
273,
7742,
387,
253,
4502,
432,
11962,
14636,
15,
380,
3110,
1364,
8251,
247,
16572,
1481,
3665,
281,
1978,
253,
1481,
1335,
15,
380,
3510,
273,
14166,
302,
9994,
7742,
6742,
4390,
2130,
403,
19025,
8325,
13,
4872,
44420,
313,
29193,
1934,
582,
285,
17356,
12798,
15,
2726,
14166,
302,
9994,
6742,
13,
253,
4502,
1364,
320,
387,
1878,
608,
5823,
432,
253,
26961,
21477,
4542,
281,
3657,
7742,
4723,
15,
831,
1971,
476,
4536,
320,
2218,
275,
247,
2014,
6874,
13,
8493,
253,
2495,
273,
4723,
281,
8704,
4408,
15,
187,
50262,
187,
3074,
4948,
273,
7742,
4918,
2847,
247,
26830,
10343,
275,
3275,
273,
643,
37804,
23884,
689,
673,
13,
4795,
275,
253,
878,
323,
14689,
5407,
275,
954,
1363,
15,
7754,
2492,
671,
476,
11490,
247,
1363,
27161,
15,
29770,
2957,
285,
3998,
4975,
403,
7520,
10552,
15,
44605,
314,
13,
6561,
8837,
476,
1287,
1142,
1107,
1996,
275,
3672,
326,
497,
275,
253,
1854,
273,
253,
7742,
8325,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
403,
253,
9694,
323,
5192,
409,
909,
5242,
3736,
26747,
13,
1971,
4610,
2486,
9205,
8570,
273,
253,
4502,
13,
3739,
4918,
13,
285,
7742,
4918,
273,
253,
37804,
15,
187,
50262,
187,
6826,
932,
273,
1971,
403,
281,
187,
50262,
187,
14,
4796,
6714,
14689,
3275,
281,
2622,
2308,
50276,
14,
29522,
253,
3473,
326,
253,
5675,
37804,
4502,
778,
320,
14227,
272,
327,
253,
8704,
3998,
3672,
50276,
14,
14003,
2622,
37804,
1159,
390,
1555,
14689,
30218,
50276,
14,
3157,
253,
5917,
273,
913,
409,
909,
5242,
187,
50262,
187,
14102,
5158,
187,
50262,
187,
14102,
5158,
310,
253,
806,
4500,
8521,
323,
954,
952,
342,
913,
409,
909,
5242,
13,
347,
352,
310,
2223,
247,
5233,
285,
3576,
1971,
15,
380,
20997,
14190,
253,
37804,
3066,
271,
33708,
949,
253,
11480,
390,
3304,
253,
5170,
5541,
285,
13,
342,
2714,
5657,
13,
26586,
253,
4502,
4408,
275,
247,
5199,
1925,
811,
1033,
864,
16080,
5869,
15,
831,
5199,
25122,
18604,
1634,
253,
3473,
327,
253,
8704,
3998,
4811,
285,
5644,
281,
247,
5233,
23345,
273,
22419,
2308,
15,
1310,
253,
5869,
310,
5547,
13,
17754,
7286,
285,
2602,
4408,
25567,
3157,
1561,
247,
1643,
1897,
15,
187,
50262,
187,
14102,
5158,
310,
954,
5547,
275,
1363,
342,
2614,
22419,
2308,
2708,
5329,
9782,
16,
1686,
1078,
253,
4254,
285,
342,
37804,
8837,
642,
4067,
685,
884,
5499,
29399,
313,
2188,
10,
275,
9080,
15,
22764,
7024,
275,
1781,
629,
327,
253,
10861,
285,
2793,
273,
253,
20997,
13,
347,
973,
347,
253,
4328,
273,
253,
4502,
15,
4952,
342,
253,
954,
7407,
6551,
9960,
32719,
13,
253,
4839,
273,
247,
16498,
310,
1355,
604,
253,
4502,
556,
6508,
715,
4619,
3998,
5289,
390,
715,
253,
46531,
528,
22749,
835,
5869,
812,
320,
29198,
15,
187,
50262,
187,
510,
2323,
2281,
671,
7024,
327,
752,
1268,
273,
22419,
310,
2931,
347,
247,
16498,
15,
380,
1682,
2557,
273,
9205,
2323,
310,
21539,
273,
22419,
285,
23591,
14,
42,
2308,
15,
380,
4583,
2281,
273,
31701,
14,
8519,
273,
253,
2728,
14,
6438,
5869,
13794,
432,
7288,
281,
5096,
2558,
15,
313,
5035,
1198,
3010,
8339,
281,
19912,
247,
4450,
14,
15004,
1245,
6551,
9960,
32719,
2698,
187,
50262,
187,
34,
1896,
23950,
273,
5869,
310,
4723,
281,
253,
8704,
2622,
37804,
4408,
13,
534,
4419,
36536,
897,
273,
37804,
14689,
5407,
15,
380,
629,
273,
253,
37804,
326,
10111,
1331,
13535,
459,
3028,
14689,
66,
14689,
1774,
275,
1824,
6654,
11159,
320,
20220,
390,
13,
11766,
13,
21311,
13572,
285,
253,
3110,
778,
2430,
3739,
4918,
15,
5131,
2442,
3237,
2486,
34879,
45895,
6514,
31693,
285,
13,
11766,
13,
30091,
5895,
15,
330,
11892,
9108,
45895,
6514,
10464,
1041,
253,
3998,
285,
476,
13584,
432,
253,
11480,
604,
253,
33708,
2170,
36908,
20658,
973,
15,
353,
2980,
5895,
310,
247,
10741,
390,
9907,
5066,
273,
253,
30091,
265,
13,
253,
8346,
10985,
273,
253,
3998,
15,
187,
50262,
187,
9586,
672,
5869,
310,
5547,
285,
14689,
2308,
1091,
281,
2622,
13,
952,
342,
913,
409,
909,
5242,
1364,
320,
9257,
16387,
323,
1107,
323,
1896,
15969,
273,
253,
2728,
15,
3010,
7744,
13,
14689,
2308,
3157,
13,
533,
513,
417,
1091,
281,
2622,
15,
14117,
1971,
13,
3798,
16940,
13,
778,
320,
2424,
15,
187,
50262,
187,
41225,
34294,
187,
50262,
187,
41225,
4918,
310,
954,
2223,
908,
604,
5869,
1057,
417,
906,
275,
247,
16498,
285,
4536,
281,
23973,
1781,
8837,
1078,
5869,
15,
9064,
12358,
2390,
403,
908,
281,
1555,
913,
409,
909,
5242,
15,
187,
50262,
187,
52,
16692,
49897,
43121,
313,
3528,
1909,
10,
403,
253,
806,
12358,
1387,
908,
281,
1555,
913,
409,
909,
5242,
15,
1583,
6294,
745,
22419,
3275,
285,
403,
3576,
275,
23345,
22419,
285,
23591,
14,
42,
2308,
275,
2456,
281,
5571,
2558,
273,
1363,
15,
13575,
1909,
671,
4796,
4502,
1979,
275,
1475,
470,
281,
2456,
2558,
273,
1363,
533,
760,
281,
247,
16453,
4248,
15,
12090,
2175,
452,
2011,
326,
13575,
1909,
403,
4999,
285,
3576,
323,
1048,
14,
3945,
1971,
285,
275,
12767,
1363,
342,
913,
409,
909,
5242,
4269,
407,
1327,
18086,
32419,
8837,
15,
8057,
14,
20594,
13575,
1909,
403,
1677,
407,
34626,
35109,
8829,
2378,
247,
1770,
15,
187,
50262,
187,
19224,
383,
422,
3237,
14,
10328,
347,
13155,
331,
23699,
13,
33706,
13,
285,
3678,
14,
609,
247,
1930,
1055,
275,
670,
2716,
273,
952,
3192,
13575,
1909,
15,
1723,
13,
253,
2538,
403,
3798,
11287,
285,
11766,
5460,
15,
11376,
884,
281,
1384,
2558,
273,
1363,
1287,
9391,
35695,
13,
533,
253,
9391,
35695,
513,
417,
3798,
2847,
5917,
15,
496,
7520,
2219,
13,
1971,
476,
906,
275,
10702,
2614,
8383,
2308,
15,
3010,
7744,
13,
13575,
1909,
4796,
253,
878,
323,
9442,
285,
3157,
2614,
8383,
1453,
275,
690,
952,
342,
913,
409,
909,
5242,
665,
2168,
452,
8401,
15,
187,
50262,
187,
510,
1273,
12358,
1387,
310,
253,
22419,
6437,
33226,
313,
40,
9914,
1909,
582,
534,
19323,
342,
253,
2250,
273,
22419,
15,
1583,
39142,
23591,
14,
42,
2308,
275,
625,
685,
5091,
2558,
273,
1363,
15,
1583,
513,
417,
13,
2299,
13,
2406,
22419,
2308,
15,
10300,
2378,
247,
1388,
949,
8829,
13,
443,
9914,
1909,
403,
3798,
973,
14,
34776,
12072,
407,
1363,
15,
380,
1048,
14,
3945,
2538,
273,
841,
5835,
327,
4502,
3116,
403,
1335,
762,
1263,
15,
19942,
2538,
476,
2486,
37403,
13,
18693,
13,
285,
10969,
6728,
1159,
15,
187,
50262,
187,
37,
412,
6771,
36541,
1056,
598,
253,
2626,
12358,
1387,
15,
2053,
5835,
403,
417,
347,
3576,
347,
253,
643,
16940,
387,
23345,
22419,
390,
23591,
14,
42,
2308,
13,
285,
597,
39142,
23591,
14,
42,
2308,
275,
760,
247,
15156,
273,
1363,
15,
399,
412,
6771,
36541,
403,
4536,
3576,
275,
1363,
665,
452,
11134,
7759,
273,
6714,
22419,
285,
452,
1097,
913,
409,
909,
5242,
285,
4373,
856,
77,
20050,
358,
5946,
3288,
1199,
273,
253,
14689,
27400,
20050,
15,
399,
412,
6771,
36541,
476,
320,
908,
275,
5019,
342,
13575,
1909,
15,
19942,
2538,
476,
2486,
33706,
13,
24934,
13,
285,
1708,
24818,
1255,
15,
187,
50262,
187,
8903,
251,
382,
27,
329,
2854,
326,
22294,
281,
247,
6437,
273,
247,
894,
285,
23785,
247,
2380,
407,
253,
894,
13,
13892,
12427,
253,
2250,
273,
247,
10748,
12952,
10359,
15,
50275,
24657,
5154,
382,
27,
329,
5793,
326,
6993,
1561,
253,
2133,
281,
4796,
253,
13424,
2425,
273,
1529,
5793,
10359,
390,
14689,
15,
187,
50262,
187,
13021,
2492,
34294,
187,
50262,
187,
13021,
2492,
4918,
310,
3798,
10827,
323,
952,
665,
452,
690,
4502,
5780,
846,
5869,
285,
513,
417,
3794,
281,
16940,
15,
4923,
7742,
5644,
281,
247,
3468,
23345,
273,
22419,
285,
23591,
14,
42,
2308,
13,
841,
1363,
2223,
671,
4763,
12358,
281,
2406,
14689,
2308,
15,
380,
2120,
1055,
273,
436,
4918,
778,
417,
2826,
323,
1142,
1107,
15,
187,
50262,
187,
510,
767,
3510,
273,
7742,
6742,
403,
6041,
285,
14166,
302,
9994,
15,
44347,
7742,
6742,
8571,
253,
4502,
342,
6024,
20435,
533,
476,
4723,
8704,
4408,
15,
380,
1971,
26361,
1355,
12768,
273,
7742,
2709,
2069,
689,
577,
281,
721,
3618,
13,
4933,
2622,
4408,
673,
281,
20658,
875,
9694,
15,
187,
50262,
187,
6812,
250,
302,
9994,
6742,
4483,
10799,
12262,
273,
247,
1029,
14,
19572,
8325,
273,
7742,
387,
253,
4502,
432,
11962,
14636,
15,
380,
3110,
1364,
8251,
247,
16572,
1481,
3665,
281,
1978,
253,
1481,
1335,
15,
380,
3510,
273,
14166,
302,
9994,
7742,
6742,
4390,
2130,
403,
19025,
8325,
13,
4872,
44420,
313,
29193,
1934,
582,
285,
17356,
12798,
15,
2726,
14166,
302,
9994,
6742,
13,
253,
4502,
1364,
320,
387,
1878,
608,
5823,
432,
253,
26961,
21477,
4542,
281,
3657,
7742,
4723,
15,
831,
1971,
476,
4536,
320,
2218,
275,
247,
2014,
6874,
13,
8493,
253,
2495,
273,
4723,
281,
8704,
4408,
15,
187,
50262,
187,
3074,
4948,
273,
7742,
4918,
2847,
247,
26830,
10343,
275,
3275,
273,
643,
37804,
23884,
689,
673,
13,
4795,
275,
253,
878,
323,
14689,
5407,
275,
954,
1363,
15,
7754,
2492,
671,
476,
11490,
247,
1363,
27161,
15,
29770,
2957,
285,
3998,
4975,
403,
7520,
10552,
15,
44605,
314,
13,
6561,
8837,
476,
1287,
1142,
1107,
1996,
275,
3672,
326,
497,
275,
253,
1854,
273,
253,
7742,
8325,
15
] |
How to diagnose Adult Hodgkin Lymphoma ? | Tests that examine the lymph nodes are used to detect (find) and diagnose adult Hodgkin lymphoma. The following tests and procedures may be used: - Physical exam and history : An exam of the body to check general signs of health, including checking for signs of disease, such as lumps or anything else that seems unusual. A history of the patient's past illnesses and treatments will also be taken. - Complete blood count (CBC): A procedure in which a sample of blood is drawn and checked for the following: - The number of red blood cells, white blood cells, and platelets. - The amount of hemoglobin (the protein that carries oxygen) in the red blood cells. - The portion of the sample made up of red blood cells. - Blood chemistry studies : A procedure in which a blood sample is checked to measure the amounts of certain substances released into the blood by organs and tissues in the body. An unusual (higher or lower than normal) amount of a substance can be a sign of disease. - Sedimentation rate : A procedure in which a sample of blood is drawn and checked for the rate at which the red blood cells settle to the bottom of the test tube. The sedimentation rate is a measure of how much inflammation is in the body. A higher than normal sedimentation rate may be a sign of lymphoma or another condition. Also called erythrocyte sedimentation rate, sed rate, or ESR. - Lymph node biopsy : The removal of all or part of a lymph node. One of the following types of biopsies may be done: - Excisional biopsy : The removal of an entire lymph node. - Incisional biopsy : The removal of part of a lymph node. - Core biopsy : The removal of part of a lymph node using a wide needle. A pathologist views the tissue under a microscope to look for cancer cells, especially Reed-Sternberg cells. Reed-Sternberg cells are common in classical Hodgkin lymphoma. The following test may be done on tissue that was removed: - Immunophenotyping : A laboratory test used to identify cells, based on the types of antigens or markers on the surface of the cell. This test is used to diagnose the specific type of lymphoma by comparing the cancer cells to normal cells of the immune system. | [
2347,
281,
33901,
32967,
28940,
72,
5914,
49684,
3691,
3736,
26943,
326,
9186,
253,
6946,
7632,
403,
908,
281,
2736,
313,
8606,
10,
285,
33901,
6782,
28940,
72,
5914,
24964,
15,
380,
1563,
5216,
285,
7259,
778,
320,
908,
27,
50269,
14,
50275,
35227,
1174,
285,
2892,
1163,
743,
1174,
273,
253,
2133,
281,
2451,
2087,
7871,
273,
1786,
13,
1690,
12669,
323,
7871,
273,
2728,
13,
824,
347,
298,
10628,
390,
2712,
2010,
326,
3133,
11555,
15,
329,
2892,
273,
253,
3110,
434,
2469,
31372,
285,
9694,
588,
671,
320,
2668,
15,
50274,
14,
50275,
26626,
2614,
1385,
313,
40222,
2262,
329,
5199,
275,
534,
247,
3410,
273,
2614,
310,
8392,
285,
10141,
323,
253,
1563,
27,
50262,
14,
380,
1180,
273,
2502,
2614,
1341,
13,
3168,
2614,
1341,
13,
285,
32359,
15,
50272,
14,
380,
2408,
273,
30242,
313,
783,
2601,
326,
15814,
7768,
10,
275,
253,
2502,
2614,
1341,
15,
50272,
14,
380,
5110,
273,
253,
3410,
1160,
598,
273,
2502,
2614,
1341,
15,
50265,
14,
50275,
30456,
18090,
2175,
1163,
329,
5199,
275,
534,
247,
2614,
3410,
310,
10141,
281,
2557,
253,
8322,
273,
2176,
15991,
4439,
715,
253,
2614,
407,
15384,
285,
7944,
275,
253,
2133,
15,
743,
11555,
313,
41832,
390,
2406,
685,
2622,
10,
2408,
273,
247,
10359,
476,
320,
247,
861,
273,
2728,
15,
50274,
14,
50275,
52,
264,
2092,
318,
2281,
1163,
329,
5199,
275,
534,
247,
3410,
273,
2614,
310,
8392,
285,
10141,
323,
253,
2281,
387,
534,
253,
2502,
2614,
1341,
16359,
281,
253,
5004,
273,
253,
1071,
9402,
15,
380,
26556,
318,
2281,
310,
247,
2557,
273,
849,
1199,
10696,
310,
275,
253,
2133,
15,
329,
2169,
685,
2622,
26556,
318,
2281,
778,
320,
247,
861,
273,
24964,
390,
1529,
1617,
15,
5220,
1925,
21564,
31948,
26556,
318,
2281,
13,
9043,
2281,
13,
390,
42209,
15,
50274,
14,
50276,
45,
6011,
4666,
18323,
1163,
380,
8570,
273,
512,
390,
629,
273,
247,
6946,
4666,
15,
2596,
273,
253,
1563,
3510,
273,
33537,
778,
320,
2218,
27,
50262,
14,
50276,
1672,
68,
1297,
267,
18323,
1163,
380,
8570,
273,
271,
2862,
6946,
4666,
15,
50271,
14,
50276,
29228,
1297,
267,
18323,
1163,
380,
8570,
273,
629,
273,
247,
6946,
4666,
15,
50272,
14,
50276,
13745,
18323,
1163,
380,
8570,
273,
629,
273,
247,
6946,
4666,
970,
247,
4618,
15460,
15,
50268,
34,
1854,
10364,
6849,
253,
4408,
762,
247,
17199,
281,
1007,
323,
2923,
1341,
13,
3340,
24518,
14,
52,
931,
4978,
1341,
15,
24518,
14,
52,
931,
4978,
1341,
403,
1846,
275,
8946,
28940,
72,
5914,
24964,
15,
50276,
510,
1563,
1071,
778,
320,
2218,
327,
4408,
326,
369,
5176,
27,
50263,
14,
50276,
30458,
34731,
23943,
1163,
329,
9965,
1071,
908,
281,
4271,
1341,
13,
1754,
327,
253,
3510,
273,
22240,
390,
9588,
327,
253,
2553,
273,
253,
894,
15,
831,
1071,
310,
908,
281,
33901,
253,
2173,
1511,
273,
24964,
407,
10941,
253,
2923,
1341,
281,
2622,
1341,
273,
253,
7026,
985,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
2347,
281,
33901,
32967,
28940,
72,
5914,
49684,
3691,
3736,
26943,
326,
9186,
253,
6946,
7632,
403,
908,
281,
2736,
313,
8606,
10,
285,
33901,
6782,
28940,
72,
5914,
24964,
15,
380,
1563,
5216,
285,
7259,
778,
320,
908,
27,
50269,
14,
50275,
35227,
1174,
285,
2892,
1163,
743,
1174,
273,
253,
2133,
281,
2451,
2087,
7871,
273,
1786,
13,
1690,
12669,
323,
7871,
273,
2728,
13,
824,
347,
298,
10628,
390,
2712,
2010,
326,
3133,
11555,
15,
329,
2892,
273,
253,
3110,
434,
2469,
31372,
285,
9694,
588,
671,
320,
2668,
15,
50274,
14,
50275,
26626,
2614,
1385,
313,
40222,
2262,
329,
5199,
275,
534,
247,
3410,
273,
2614,
310,
8392,
285,
10141,
323,
253,
1563,
27,
50262,
14,
380,
1180,
273,
2502,
2614,
1341,
13,
3168,
2614,
1341,
13,
285,
32359,
15,
50272,
14,
380,
2408,
273,
30242,
313,
783,
2601,
326,
15814,
7768,
10,
275,
253,
2502,
2614,
1341,
15,
50272,
14,
380,
5110,
273,
253,
3410,
1160,
598,
273,
2502,
2614,
1341,
15,
50265,
14,
50275,
30456,
18090,
2175,
1163,
329,
5199,
275,
534,
247,
2614,
3410,
310,
10141,
281,
2557,
253,
8322,
273,
2176,
15991,
4439,
715,
253,
2614,
407,
15384,
285,
7944,
275,
253,
2133,
15,
743,
11555,
313,
41832,
390,
2406,
685,
2622,
10,
2408,
273,
247,
10359,
476,
320,
247,
861,
273,
2728,
15,
50274,
14,
50275,
52,
264,
2092,
318,
2281,
1163,
329,
5199,
275,
534,
247,
3410,
273,
2614,
310,
8392,
285,
10141,
323,
253,
2281,
387,
534,
253,
2502,
2614,
1341,
16359,
281,
253,
5004,
273,
253,
1071,
9402,
15,
380,
26556,
318,
2281,
310,
247,
2557,
273,
849,
1199,
10696,
310,
275,
253,
2133,
15,
329,
2169,
685,
2622,
26556,
318,
2281,
778,
320,
247,
861,
273,
24964,
390,
1529,
1617,
15,
5220,
1925,
21564,
31948,
26556,
318,
2281,
13,
9043,
2281,
13,
390,
42209,
15,
50274,
14,
50276,
45,
6011,
4666,
18323,
1163,
380,
8570,
273,
512,
390,
629,
273,
247,
6946,
4666,
15,
2596,
273,
253,
1563,
3510,
273,
33537,
778,
320,
2218,
27,
50262,
14,
50276,
1672,
68,
1297,
267,
18323,
1163,
380,
8570,
273,
271,
2862,
6946,
4666,
15,
50271,
14,
50276,
29228,
1297,
267,
18323,
1163,
380,
8570,
273,
629,
273,
247,
6946,
4666,
15,
50272,
14,
50276,
13745,
18323,
1163,
380,
8570,
273,
629,
273,
247,
6946,
4666,
970,
247,
4618,
15460,
15,
50268,
34,
1854,
10364,
6849,
253,
4408,
762,
247,
17199,
281,
1007,
323,
2923,
1341,
13,
3340,
24518,
14,
52,
931,
4978,
1341,
15,
24518,
14,
52,
931,
4978,
1341,
403,
1846,
275,
8946,
28940,
72,
5914,
24964,
15,
50276,
510,
1563,
1071,
778,
320,
2218,
327,
4408,
326,
369,
5176,
27,
50263,
14,
50276,
30458,
34731,
23943,
1163,
329,
9965,
1071,
908,
281,
4271,
1341,
13,
1754,
327,
253,
3510,
273,
22240,
390,
9588,
327,
253,
2553,
273,
253,
894,
15,
831,
1071,
310,
908,
281,
33901,
253,
2173,
1511,
273,
24964,
407,
10941,
253,
2923,
1341,
281,
2622,
1341,
273,
253,
7026,
985,
15
] |
What are the symptoms of VACTERL association ? | What are the signs and symptoms of VACTERL association? The Human Phenotype Ontology provides the following list of signs and symptoms for VACTERL association. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Aplasia/Hypoplasia of the lungs 90% Polyhydramnios 90% Premature birth 90% Tracheal stenosis 90% Tracheoesophageal fistula 90% Urogenital fistula 90% Abnormal localization of kidney 50% Abnormality of the cardiac septa 50% Aplasia/Hypoplasia of the radius 50% Congenital diaphragmatic hernia 50% Laryngomalacia 50% Renal hypoplasia/aplasia 50% Vertebral segmentation defect 50% Abnormality of female internal genitalia 7.5% Abnormality of the fontanelles or cranial sutures 7.5% Abnormality of the gallbladder 7.5% Abnormality of the intervertebral disk 7.5% Abnormality of the pancreas 7.5% Abnormality of the ribs 7.5% Abnormality of the sacrum 7.5% Anencephaly 7.5% Bifid scrotum 7.5% Cavernous hemangioma 7.5% Cleft palate 7.5% Cryptorchidism 7.5% Displacement of the external urethral meatus 7.5% Encephalocele 7.5% Finger syndactyly 7.5% Hypoplasia of penis 7.5% Intrauterine growth retardation 7.5% Low-set, posteriorly rotated ears 7.5% Multicystic kidney dysplasia 7.5% Non-midline cleft lip 7.5% Omphalocele 7.5% Preaxial hand polydactyly 7.5% Single umbilical artery 7.5% Abnormality of the nasopharynx - Abnormality of the sternum - Absent radius - Anal atresia - Choanal atresia - Ectopic kidney - Esophageal atresia - Failure to thrive - Hydronephrosis - Hypoplasia of the radius - Hypospadias - Large fontanelles - Laryngeal stenosis - Occipital encephalocele - Patent ductus arteriosus - Patent urachus - Postnatal growth retardation - Radioulnar synostosis - Renal agenesis - Renal dysplasia - Scoliosis - Short thumb - Spina bifida - Sporadic - Syndactyly - Tethered cord - Tetralogy of Fallot - Transposition of the great arteries - Triphalangeal thumb - Ureteropelvic junction obstruction - Ventricular septal defect - Vesicoureteral reflux - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common. | [
1276,
403,
253,
5917,
273,
657,
11645,
947,
45,
5864,
3736,
1276,
403,
253,
7871,
285,
5917,
273,
657,
11645,
947,
45,
5864,
32,
380,
8801,
34689,
5174,
15195,
1497,
3400,
253,
1563,
1618,
273,
7871,
285,
5917,
323,
657,
11645,
947,
45,
5864,
15,
1310,
253,
1491,
310,
2130,
13,
253,
2829,
2708,
3797,
849,
2223,
253,
19831,
310,
2326,
275,
952,
342,
436,
1617,
15,
1422,
476,
897,
253,
3050,
1282,
25263,
8710,
26372,
281,
1007,
598,
253,
14308,
323,
841,
3739,
2426,
15,
8714,
84,
285,
40561,
3056,
17274,
13954,
1180,
273,
1363,
313,
9453,
2130,
10,
329,
24506,
16,
39355,
4488,
13411,
273,
253,
18926,
5091,
6,
18371,
22034,
3358,
79,
3783,
5091,
6,
13343,
1177,
4201,
5091,
6,
1535,
2679,
267,
29940,
5091,
6,
1535,
2679,
13347,
24816,
49214,
5091,
6,
530,
12991,
1562,
49214,
5091,
6,
3506,
6320,
14536,
273,
12333,
2456,
6,
3506,
12850,
1319,
273,
253,
10177,
22688,
66,
2456,
6,
329,
24506,
16,
39355,
4488,
13411,
273,
253,
9941,
2456,
6,
4731,
257,
1562,
34622,
1420,
617,
15298,
2456,
6,
418,
43420,
7838,
22622,
2456,
6,
12751,
267,
3500,
4488,
13411,
16,
66,
24506,
2456,
6,
7188,
442,
11887,
26405,
7071,
2456,
6,
3506,
12850,
1319,
273,
5343,
4812,
34020,
571,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
8266,
266,
18502,
390,
45752,
35339,
980,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
9391,
1559,
14630,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
734,
31861,
11887,
7592,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
35142,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
28061,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
7044,
4638,
818,
15,
22,
6,
743,
566,
545,
5242,
818,
15,
22,
6,
378,
338,
301,
660,
8601,
360,
818,
15,
22,
6,
6047,
29865,
528,
7492,
24091,
3691,
818,
15,
22,
6,
330,
1274,
45238,
818,
15,
22,
6,
28451,
263,
42290,
1204,
818,
15,
22,
6,
5201,
26380,
273,
253,
6024,
39704,
1544,
479,
3144,
818,
15,
22,
6,
3035,
336,
545,
12584,
44033,
818,
15,
22,
6,
401,
4940,
7979,
514,
90,
314,
818,
15,
22,
6,
25295,
4488,
13411,
273,
29292,
818,
15,
22,
6,
39836,
18696,
460,
3116,
48112,
818,
15,
22,
6,
11578,
14,
1178,
13,
12637,
314,
27272,
13628,
818,
15,
22,
6,
9170,
2576,
11224,
12333,
48723,
818,
15,
22,
6,
8758,
14,
7893,
1282,
45793,
5541,
818,
15,
22,
6,
30542,
545,
12584,
44033,
818,
15,
22,
6,
5729,
27534,
1133,
3488,
69,
514,
90,
314,
818,
15,
22,
6,
19757,
47224,
12235,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
13332,
2689,
44793,
428,
3506,
12850,
1319,
273,
253,
24701,
360,
428,
16508,
290,
9941,
428,
14703,
387,
373,
571,
428,
13999,
14983,
387,
373,
571,
428,
444,
291,
6361,
12333,
428,
9615,
24816,
387,
373,
571,
428,
32104,
281,
34298,
428,
8305,
5267,
531,
545,
11503,
428,
25295,
4488,
13411,
273,
253,
9941,
428,
8305,
993,
11022,
6358,
428,
21157,
8266,
266,
18502,
428,
418,
28643,
29940,
428,
17763,
532,
1562,
546,
336,
545,
12584,
44033,
428,
11754,
17451,
316,
7463,
3783,
316,
428,
11754,
2936,
12903,
428,
5779,
31964,
3116,
48112,
428,
7754,
74,
3941,
27380,
2753,
493,
2433,
428,
12751,
267,
639,
257,
6090,
428,
12751,
267,
48723,
428,
1810,
10424,
2433,
428,
14196,
17300,
428,
2101,
1758,
25171,
4355,
428,
322,
1831,
18535,
428,
31181,
514,
90,
314,
428,
308,
10666,
433,
12045,
428,
37822,
1544,
15514,
273,
16275,
302,
428,
4480,
3321,
273,
253,
1270,
24908,
428,
11835,
13203,
912,
267,
17300,
428,
530,
250,
350,
412,
293,
19742,
16889,
22080,
428,
23780,
13267,
22688,
267,
7071,
428,
46602,
280,
276,
250,
45473,
39708,
428,
380,
8801,
34689,
5174,
15195,
1497,
313,
41,
5964,
10,
556,
5728,
1491,
327,
849,
2223,
247,
861,
390,
19831,
6634,
275,
247,
1617,
15,
18770,
273,
436,
1491,
3249,
432,
2207,
15671,
292,
13,
247,
5284,
7520,
2728,
5447,
15,
380,
4294,
273,
247,
861,
390,
19831,
310,
3798,
7117,
347,
247,
7227,
6642,
273,
253,
7155,
273,
1363,
665,
452,
326,
4735,
15,
380,
4294,
778,
671,
320,
7117,
347,
247,
6919,
15,
380,
806,
1180,
273,
253,
6919,
310,
849,
1142,
952,
574,
253,
19831,
13,
285,
253,
1273,
1180,
310,
253,
2264,
1180,
273,
952,
665,
497,
6730,
275,
581,
1263,
15,
1198,
1650,
13,
247,
4294,
273,
2030,
16,
1099,
2097,
326,
275,
247,
1263,
273,
2030,
952,
512,
1363,
497,
1119,
281,
452,
326,
19831,
15,
4923,
841,
11383,
403,
1754,
327,
247,
2173,
1263,
13,
253,
17711,
778,
320,
1027,
604,
1529,
1387,
273,
1363,
403,
6730,
15,
13168,
13,
642,
1491,
327,
4294,
310,
2130,
15,
496,
841,
2219,
13,
253,
861,
390,
19831,
778,
320,
7520,
390,
1846,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
403,
253,
5917,
273,
657,
11645,
947,
45,
5864,
3736,
1276,
403,
253,
7871,
285,
5917,
273,
657,
11645,
947,
45,
5864,
32,
380,
8801,
34689,
5174,
15195,
1497,
3400,
253,
1563,
1618,
273,
7871,
285,
5917,
323,
657,
11645,
947,
45,
5864,
15,
1310,
253,
1491,
310,
2130,
13,
253,
2829,
2708,
3797,
849,
2223,
253,
19831,
310,
2326,
275,
952,
342,
436,
1617,
15,
1422,
476,
897,
253,
3050,
1282,
25263,
8710,
26372,
281,
1007,
598,
253,
14308,
323,
841,
3739,
2426,
15,
8714,
84,
285,
40561,
3056,
17274,
13954,
1180,
273,
1363,
313,
9453,
2130,
10,
329,
24506,
16,
39355,
4488,
13411,
273,
253,
18926,
5091,
6,
18371,
22034,
3358,
79,
3783,
5091,
6,
13343,
1177,
4201,
5091,
6,
1535,
2679,
267,
29940,
5091,
6,
1535,
2679,
13347,
24816,
49214,
5091,
6,
530,
12991,
1562,
49214,
5091,
6,
3506,
6320,
14536,
273,
12333,
2456,
6,
3506,
12850,
1319,
273,
253,
10177,
22688,
66,
2456,
6,
329,
24506,
16,
39355,
4488,
13411,
273,
253,
9941,
2456,
6,
4731,
257,
1562,
34622,
1420,
617,
15298,
2456,
6,
418,
43420,
7838,
22622,
2456,
6,
12751,
267,
3500,
4488,
13411,
16,
66,
24506,
2456,
6,
7188,
442,
11887,
26405,
7071,
2456,
6,
3506,
12850,
1319,
273,
5343,
4812,
34020,
571,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
8266,
266,
18502,
390,
45752,
35339,
980,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
9391,
1559,
14630,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
734,
31861,
11887,
7592,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
35142,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
28061,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
7044,
4638,
818,
15,
22,
6,
743,
566,
545,
5242,
818,
15,
22,
6,
378,
338,
301,
660,
8601,
360,
818,
15,
22,
6,
6047,
29865,
528,
7492,
24091,
3691,
818,
15,
22,
6,
330,
1274,
45238,
818,
15,
22,
6,
28451,
263,
42290,
1204,
818,
15,
22,
6,
5201,
26380,
273,
253,
6024,
39704,
1544,
479,
3144,
818,
15,
22,
6,
3035,
336,
545,
12584,
44033,
818,
15,
22,
6,
401,
4940,
7979,
514,
90,
314,
818,
15,
22,
6,
25295,
4488,
13411,
273,
29292,
818,
15,
22,
6,
39836,
18696,
460,
3116,
48112,
818,
15,
22,
6,
11578,
14,
1178,
13,
12637,
314,
27272,
13628,
818,
15,
22,
6,
9170,
2576,
11224,
12333,
48723,
818,
15,
22,
6,
8758,
14,
7893,
1282,
45793,
5541,
818,
15,
22,
6,
30542,
545,
12584,
44033,
818,
15,
22,
6,
5729,
27534,
1133,
3488,
69,
514,
90,
314,
818,
15,
22,
6,
19757,
47224,
12235,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
13332,
2689,
44793,
428,
3506,
12850,
1319,
273,
253,
24701,
360,
428,
16508,
290,
9941,
428,
14703,
387,
373,
571,
428,
13999,
14983,
387,
373,
571,
428,
444,
291,
6361,
12333,
428,
9615,
24816,
387,
373,
571,
428,
32104,
281,
34298,
428,
8305,
5267,
531,
545,
11503,
428,
25295,
4488,
13411,
273,
253,
9941,
428,
8305,
993,
11022,
6358,
428,
21157,
8266,
266,
18502,
428,
418,
28643,
29940,
428,
17763,
532,
1562,
546,
336,
545,
12584,
44033,
428,
11754,
17451,
316,
7463,
3783,
316,
428,
11754,
2936,
12903,
428,
5779,
31964,
3116,
48112,
428,
7754,
74,
3941,
27380,
2753,
493,
2433,
428,
12751,
267,
639,
257,
6090,
428,
12751,
267,
48723,
428,
1810,
10424,
2433,
428,
14196,
17300,
428,
2101,
1758,
25171,
4355,
428,
322,
1831,
18535,
428,
31181,
514,
90,
314,
428,
308,
10666,
433,
12045,
428,
37822,
1544,
15514,
273,
16275,
302,
428,
4480,
3321,
273,
253,
1270,
24908,
428,
11835,
13203,
912,
267,
17300,
428,
530,
250,
350,
412,
293,
19742,
16889,
22080,
428,
23780,
13267,
22688,
267,
7071,
428,
46602,
280,
276,
250,
45473,
39708,
428,
380,
8801,
34689,
5174,
15195,
1497,
313,
41,
5964,
10,
556,
5728,
1491,
327,
849,
2223,
247,
861,
390,
19831,
6634,
275,
247,
1617,
15,
18770,
273,
436,
1491,
3249,
432,
2207,
15671,
292,
13,
247,
5284,
7520,
2728,
5447,
15,
380,
4294,
273,
247,
861,
390,
19831,
310,
3798,
7117,
347,
247,
7227,
6642,
273,
253,
7155,
273,
1363,
665,
452,
326,
4735,
15,
380,
4294,
778,
671,
320,
7117,
347,
247,
6919,
15,
380,
806,
1180,
273,
253,
6919,
310,
849,
1142,
952,
574,
253,
19831,
13,
285,
253,
1273,
1180,
310,
253,
2264,
1180,
273,
952,
665,
497,
6730,
275,
581,
1263,
15,
1198,
1650,
13,
247,
4294,
273,
2030,
16,
1099,
2097,
326,
275,
247,
1263,
273,
2030,
952,
512,
1363,
497,
1119,
281,
452,
326,
19831,
15,
4923,
841,
11383,
403,
1754,
327,
247,
2173,
1263,
13,
253,
17711,
778,
320,
1027,
604,
1529,
1387,
273,
1363,
403,
6730,
15,
13168,
13,
642,
1491,
327,
4294,
310,
2130,
15,
496,
841,
2219,
13,
253,
861,
390,
19831,
778,
320,
7520,
390,
1846,
15
] |
What is (are) Colonic Polyps ? | A polyp is an extra piece of tissue that grows inside your body. Colonic polyps grow in the large intestine, or colon. Most polyps are not dangerous. However, some polyps may turn into cancer or already be cancer. To be safe, doctors remove polyps and test them. Polyps can be removed when a doctor examines the inside of the large intestine during a colonoscopy. Anyone can get polyps, but certain people are more likely than others. You may have a greater chance of getting polyps if you - Are over age 50 - Have had polyps before - Have a family member with polyps - Have a family history of colon cancer Most colon polyps do not cause symptoms. If you have symptoms, they may include blood on your underwear or on toilet paper after a bowel movement, blood in your stool, or constipation or diarrhea lasting more than a week. NIH: National Institute of Diabetes and Digestive and Kidney Diseases | [
1276,
310,
313,
609,
10,
2065,
5120,
18371,
793,
3736,
34,
36854,
310,
271,
4465,
5313,
273,
4408,
326,
17202,
3304,
634,
2133,
15,
2065,
5120,
3488,
793,
1756,
275,
253,
1781,
28741,
13,
390,
6769,
15,
5595,
3488,
793,
403,
417,
8312,
15,
1723,
13,
690,
3488,
793,
778,
1614,
715,
2923,
390,
2168,
320,
2923,
15,
1916,
320,
4999,
13,
11576,
5386,
3488,
793,
285,
1071,
731,
15,
18371,
793,
476,
320,
5176,
672,
247,
7345,
33888,
253,
3304,
273,
253,
1781,
28741,
1309,
247,
6769,
20388,
15,
50274,
31568,
476,
755,
3488,
793,
13,
533,
2176,
952,
403,
625,
2779,
685,
2571,
15,
1422,
778,
452,
247,
3687,
4839,
273,
2970,
3488,
793,
604,
368,
50270,
14,
50276,
6723,
689,
2363,
2456,
50273,
14,
50276,
11778,
574,
3488,
793,
1078,
50273,
14,
50276,
11778,
247,
2021,
3558,
342,
3488,
793,
50273,
14,
50276,
11778,
247,
2021,
2892,
273,
6769,
2923,
50270,
10342,
6769,
3488,
793,
513,
417,
2847,
5917,
15,
1310,
368,
452,
5917,
13,
597,
778,
2486,
2614,
327,
634,
42500,
390,
327,
21487,
2929,
846,
247,
25211,
4866,
13,
2614,
275,
634,
32217,
13,
390,
1030,
32713,
390,
30709,
21692,
625,
685,
247,
2129,
15,
50274,
13652,
41,
27,
3313,
6516,
273,
34050,
285,
11568,
383,
422,
285,
26184,
2191,
35852
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
310,
313,
609,
10,
2065,
5120,
18371,
793,
3736,
34,
36854,
310,
271,
4465,
5313,
273,
4408,
326,
17202,
3304,
634,
2133,
15,
2065,
5120,
3488,
793,
1756,
275,
253,
1781,
28741,
13,
390,
6769,
15,
5595,
3488,
793,
403,
417,
8312,
15,
1723,
13,
690,
3488,
793,
778,
1614,
715,
2923,
390,
2168,
320,
2923,
15,
1916,
320,
4999,
13,
11576,
5386,
3488,
793,
285,
1071,
731,
15,
18371,
793,
476,
320,
5176,
672,
247,
7345,
33888,
253,
3304,
273,
253,
1781,
28741,
1309,
247,
6769,
20388,
15,
50274,
31568,
476,
755,
3488,
793,
13,
533,
2176,
952,
403,
625,
2779,
685,
2571,
15,
1422,
778,
452,
247,
3687,
4839,
273,
2970,
3488,
793,
604,
368,
50270,
14,
50276,
6723,
689,
2363,
2456,
50273,
14,
50276,
11778,
574,
3488,
793,
1078,
50273,
14,
50276,
11778,
247,
2021,
3558,
342,
3488,
793,
50273,
14,
50276,
11778,
247,
2021,
2892,
273,
6769,
2923,
50270,
10342,
6769,
3488,
793,
513,
417,
2847,
5917,
15,
1310,
368,
452,
5917,
13,
597,
778,
2486,
2614,
327,
634,
42500,
390,
327,
21487,
2929,
846,
247,
25211,
4866,
13,
2614,
275,
634,
32217,
13,
390,
1030,
32713,
390,
30709,
21692,
625,
685,
247,
2129,
15,
50274,
13652,
41,
27,
3313,
6516,
273,
34050,
285,
11568,
383,
422,
285,
26184,
2191,
35852
] |
What are the treatments for branchiootorenal/branchiootic syndrome ? | These resources address the diagnosis or management of branchiootorenal/branchiootic syndrome: - Gene Review: Gene Review: Branchiootorenal Spectrum Disorders - Genetic Testing Registry: Branchiootic syndrome - Genetic Testing Registry: Branchiootic syndrome 2 - Genetic Testing Registry: Branchiootic syndrome 3 - Genetic Testing Registry: Branchiootorenal syndrome 2 - Genetic Testing Registry: Melnick-Fraser syndrome - MedlinePlus Encyclopedia: Branchial Cleft Cyst - MedlinePlus Encyclopedia: End-Stage Kidney Disease These resources from MedlinePlus offer information about the diagnosis and management of various health conditions: - Diagnostic Tests - Drug Therapy - Surgery and Rehabilitation - Genetic Counseling - Palliative Care | [
1276,
403,
253,
9694,
323,
7789,
900,
302,
410,
2110,
16,
27391,
900,
3875,
9237,
3736,
6872,
5300,
2953,
253,
6120,
390,
4323,
273,
7789,
900,
302,
410,
2110,
16,
27391,
900,
3875,
9237,
27,
50276,
14,
15763,
8439,
27,
15763,
8439,
27,
25474,
900,
302,
410,
2110,
46177,
49566,
50276,
14,
37003,
30750,
38227,
27,
25474,
900,
3875,
9237,
50276,
14,
37003,
30750,
38227,
27,
25474,
900,
3875,
9237,
374,
50276,
14,
37003,
30750,
38227,
27,
25474,
900,
3875,
9237,
495,
50276,
14,
37003,
30750,
38227,
27,
25474,
900,
302,
410,
2110,
9237,
374,
50276,
14,
37003,
30750,
38227,
27,
8359,
23237,
14,
4604,
12290,
9237,
50276,
14,
3050,
1282,
25263,
43338,
27,
25474,
451,
330,
1274,
330,
9207,
50276,
14,
3050,
1282,
25263,
43338,
27,
8072,
14,
30635,
26184,
2191,
18742,
50275,
6872,
5300,
432,
3050,
1282,
25263,
3959,
1491,
670,
253,
6120,
285,
4323,
273,
2710,
1786,
2515,
27,
50276,
14,
44194,
32503,
50276,
14,
16686,
34294,
50276,
14,
34621,
285,
49251,
50276,
14,
37003,
19330,
272,
50275,
14,
42745,
18168,
9776
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
403,
253,
9694,
323,
7789,
900,
302,
410,
2110,
16,
27391,
900,
3875,
9237,
3736,
6872,
5300,
2953,
253,
6120,
390,
4323,
273,
7789,
900,
302,
410,
2110,
16,
27391,
900,
3875,
9237,
27,
50276,
14,
15763,
8439,
27,
15763,
8439,
27,
25474,
900,
302,
410,
2110,
46177,
49566,
50276,
14,
37003,
30750,
38227,
27,
25474,
900,
3875,
9237,
50276,
14,
37003,
30750,
38227,
27,
25474,
900,
3875,
9237,
374,
50276,
14,
37003,
30750,
38227,
27,
25474,
900,
3875,
9237,
495,
50276,
14,
37003,
30750,
38227,
27,
25474,
900,
302,
410,
2110,
9237,
374,
50276,
14,
37003,
30750,
38227,
27,
8359,
23237,
14,
4604,
12290,
9237,
50276,
14,
3050,
1282,
25263,
43338,
27,
25474,
451,
330,
1274,
330,
9207,
50276,
14,
3050,
1282,
25263,
43338,
27,
8072,
14,
30635,
26184,
2191,
18742,
50275,
6872,
5300,
432,
3050,
1282,
25263,
3959,
1491,
670,
253,
6120,
285,
4323,
273,
2710,
1786,
2515,
27,
50276,
14,
44194,
32503,
50276,
14,
16686,
34294,
50276,
14,
34621,
285,
49251,
50276,
14,
37003,
19330,
272,
50275,
14,
42745,
18168,
9776
] |
What is (are) Hyperthyroidism ? | The thyroid is a 2-inch-long, butterfly-shaped gland weighing less than 1 ounce. Located in the front of the neck below the larynx, or voice box, it has two lobes, one on each side of the windpipe. The thyroid is one of the glands that make up the endocrine system. The glands of the endocrine system produce, store, and release hormones into the bloodstream. The hormones then travel through the body and direct the activity of the bodys cells.
The thyroid gland makes two thyroid hormones, triiodothyronine (T3) and thyroxine (T4). T3 is made from T4 and is the more active hormone, directly affecting the tissues. Thyroid hormones affect metabolism, brain development, breathing, heart and nervous system functions, body temperature, muscle strength, skin dryness, menstrual cycles, weight, and cholesterol levels.
Thyroid hormone production is regulated by thyroid-stimulating hormone (TSH), which is made by the pituitary gland in the brain. When thyroid hormone levels in the blood are low, the pituitary releases more TSH. When thyroid hormone levels are high, the pituitary responds by decreasing TSH production. | [
1276,
310,
313,
609,
10,
25411,
24085,
37739,
3736,
510,
17298,
310,
247,
374,
14,
12099,
14,
5056,
13,
38985,
14,
13824,
21147,
27466,
1679,
685,
337,
38831,
15,
18771,
456,
275,
253,
2914,
273,
253,
7623,
2708,
253,
298,
44793,
13,
390,
4318,
3817,
13,
352,
556,
767,
43253,
13,
581,
327,
1016,
1930,
273,
253,
5448,
25209,
15,
380,
17298,
310,
581,
273,
253,
29108,
326,
1056,
598,
253,
35527,
985,
15,
380,
29108,
273,
253,
35527,
985,
4711,
13,
4657,
13,
285,
3727,
23884,
715,
253,
2614,
4963,
15,
380,
23884,
840,
4288,
949,
253,
2133,
285,
1480,
253,
2425,
273,
253,
18400,
656,
1341,
15,
187,
50262,
187,
510,
17298,
21147,
2789,
767,
17298,
23884,
13,
1195,
1970,
16715,
1406,
460,
313,
53,
20,
10,
285,
10386,
41636,
460,
313,
53,
21,
481,
308,
20,
310,
1160,
432,
308,
21,
285,
310,
253,
625,
3939,
14689,
13,
3587,
13567,
253,
7944,
15,
39117,
2631,
23884,
2818,
11082,
13,
3998,
2440,
13,
14578,
13,
2798,
285,
11219,
985,
3470,
13,
2133,
3276,
13,
6616,
4757,
13,
4808,
6079,
1255,
13,
46182,
11945,
13,
2801,
13,
285,
13559,
2308,
15,
187,
50262,
187,
1044,
90,
2631,
14689,
3275,
310,
13527,
407,
17298,
14,
15980,
8287,
14689,
313,
53,
5648,
582,
534,
310,
1160,
407,
253,
37804,
21147,
275,
253,
3998,
15,
2091,
17298,
14689,
2308,
275,
253,
2614,
403,
1698,
13,
253,
37804,
16784,
625,
308,
5648,
15,
2091,
17298,
14689,
2308,
403,
1029,
13,
253,
37804,
27019,
407,
11052,
308,
5648,
3275,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
310,
313,
609,
10,
25411,
24085,
37739,
3736,
510,
17298,
310,
247,
374,
14,
12099,
14,
5056,
13,
38985,
14,
13824,
21147,
27466,
1679,
685,
337,
38831,
15,
18771,
456,
275,
253,
2914,
273,
253,
7623,
2708,
253,
298,
44793,
13,
390,
4318,
3817,
13,
352,
556,
767,
43253,
13,
581,
327,
1016,
1930,
273,
253,
5448,
25209,
15,
380,
17298,
310,
581,
273,
253,
29108,
326,
1056,
598,
253,
35527,
985,
15,
380,
29108,
273,
253,
35527,
985,
4711,
13,
4657,
13,
285,
3727,
23884,
715,
253,
2614,
4963,
15,
380,
23884,
840,
4288,
949,
253,
2133,
285,
1480,
253,
2425,
273,
253,
18400,
656,
1341,
15,
187,
50262,
187,
510,
17298,
21147,
2789,
767,
17298,
23884,
13,
1195,
1970,
16715,
1406,
460,
313,
53,
20,
10,
285,
10386,
41636,
460,
313,
53,
21,
481,
308,
20,
310,
1160,
432,
308,
21,
285,
310,
253,
625,
3939,
14689,
13,
3587,
13567,
253,
7944,
15,
39117,
2631,
23884,
2818,
11082,
13,
3998,
2440,
13,
14578,
13,
2798,
285,
11219,
985,
3470,
13,
2133,
3276,
13,
6616,
4757,
13,
4808,
6079,
1255,
13,
46182,
11945,
13,
2801,
13,
285,
13559,
2308,
15,
187,
50262,
187,
1044,
90,
2631,
14689,
3275,
310,
13527,
407,
17298,
14,
15980,
8287,
14689,
313,
53,
5648,
582,
534,
310,
1160,
407,
253,
37804,
21147,
275,
253,
3998,
15,
2091,
17298,
14689,
2308,
275,
253,
2614,
403,
1698,
13,
253,
37804,
16784,
625,
308,
5648,
15,
2091,
17298,
14689,
2308,
403,
1029,
13,
253,
37804,
27019,
407,
11052,
308,
5648,
3275,
15
] |
What are the symptoms of Behcet's disease ? | What are the signs and symptoms of Behcet's disease? Symptoms of Behcet's disease include recurrent ulcers in the mouth (resembling canker sores) and on the genitals, and eye inflammation (uveitis). The disorder may also cause various types of skin lesions, arthritis, bowel inflammation, meningitis (inflammation of the membranes of the brain and spinal cord), and cranial nerve palsies. Behcet's is a multi-system disease; it may involve all organs and affect the central nervous system, causing memory loss and impaired speech, balance, and movement. The effects of the disease may include blindness, stroke, swelling of the spinal cord, and intestinal complications. The Human Phenotype Ontology provides the following list of signs and symptoms for Behcet's disease. If the information is available, the table below includes how often the symptom is seen in people with this condition. You can use the MedlinePlus Medical Dictionary to look up the definitions for these medical terms. Signs and Symptoms Approximate number of patients (when available) Abnormality of temperature regulation 90% Arthritis 90% Meningitis 90% Migraine 90% Myalgia 90% Nausea and vomiting 90% Orchitis 90% Photophobia 90% Vasculitis 90% Abdominal pain 50% Abnormal blistering of the skin 50% Acne 50% Arthralgia 50% Gait disturbance 50% Gastrointestinal hemorrhage 50% Hemiplegia/hemiparesis 50% Immunologic hypersensitivity 50% Reduced consciousness/confusion 50% Thrombophlebitis 50% Abnormal pyramidal signs 7.5% Abnormality of the aortic valve 7.5% Abnormality of the endocardium 7.5% Abnormality of the mitral valve 7.5% Abnormality of the myocardium 7.5% Abnormality of the pericardium 7.5% Abnormality of the pleura 7.5% Anorexia 7.5% Arterial thrombosis 7.5% Aseptic necrosis 7.5% Cataract 7.5% Cerebral ischemia 7.5% Coronary artery disease 7.5% Cranial nerve paralysis 7.5% Developmental regression 7.5% Encephalitis 7.5% Gangrene 7.5% Glomerulopathy 7.5% Hemoptysis 7.5% Hyperreflexia 7.5% Incoordination 7.5% Increased intracranial pressure 7.5% Keratoconjunctivitis sicca 7.5% Lymphadenopathy 7.5% Malabsorption 7.5% Memory impairment 7.5% Myositis 7.5% Pancreatitis 7.5% Paresthesia 7.5% Polyneuropathy 7.5% Pulmonary embolism 7.5% Pulmonary infiltrates 7.5% Renal insufficiency 7.5% Retinopathy 7.5% Retrobulbar optic neuritis 7.5% Seizures 7.5% Splenomegaly 7.5% Vertigo 7.5% Visual impairment 7.5% Weight loss 7.5% Alopecia areata - Chorioretinitis - Epididymitis - Erythema - Genital ulcers - Iridocyclitis - Iritis - Irritability - Oral ulcer - Superficial thrombophlebitis - The Human Phenotype Ontology (HPO) has collected information on how often a sign or symptom occurs in a condition. Much of this information comes from Orphanet, a European rare disease database. The frequency of a sign or symptom is usually listed as a rough estimate of the percentage of patients who have that feature. The frequency may also be listed as a fraction. The first number of the fraction is how many people had the symptom, and the second number is the total number of people who were examined in one study. For example, a frequency of 25/25 means that in a study of 25 people all patients were found to have that symptom. Because these frequencies are based on a specific study, the fractions may be different if another group of patients are examined. Sometimes, no information on frequency is available. In these cases, the sign or symptom may be rare or common. | [
1276,
403,
253,
5917,
273,
2325,
31728,
292,
434,
2728,
3736,
1276,
403,
253,
7871,
285,
5917,
273,
2325,
31728,
292,
434,
2728,
32,
40561,
3056,
273,
2325,
31728,
292,
434,
2728,
2486,
18902,
44623,
275,
253,
6208,
313,
250,
35128,
476,
6426,
594,
373,
10,
285,
327,
253,
730,
32421,
13,
285,
5130,
10696,
313,
48132,
5895,
481,
380,
8984,
778,
671,
2847,
2710,
3510,
273,
4808,
10429,
13,
21781,
13,
25211,
10696,
13,
30091,
5895,
313,
11006,
9862,
273,
253,
15403,
273,
253,
3998,
285,
14472,
12045,
582,
285,
45752,
11083,
39839,
447,
15,
2325,
31728,
292,
434,
310,
247,
4471,
14,
10394,
2728,
28,
352,
778,
6388,
512,
15384,
285,
2818,
253,
4275,
11219,
985,
13,
8479,
3541,
2957,
285,
15506,
6519,
13,
6654,
13,
285,
4866,
15,
380,
2538,
273,
253,
2728,
778,
2486,
44868,
13,
9980,
13,
25567,
273,
253,
14472,
12045,
13,
285,
16356,
10552,
15,
380,
8801,
34689,
5174,
15195,
1497,
3400,
253,
1563,
1618,
273,
7871,
285,
5917,
323,
2325,
31728,
292,
434,
2728,
15,
1310,
253,
1491,
310,
2130,
13,
253,
2829,
2708,
3797,
849,
2223,
253,
19831,
310,
2326,
275,
952,
342,
436,
1617,
15,
1422,
476,
897,
253,
3050,
1282,
25263,
8710,
26372,
281,
1007,
598,
253,
14308,
323,
841,
3739,
2426,
15,
8714,
84,
285,
40561,
3056,
17274,
13954,
1180,
273,
1363,
313,
9453,
2130,
10,
3506,
12850,
1319,
273,
3276,
7248,
5091,
6,
1780,
394,
13825,
5091,
6,
353,
2980,
5895,
5091,
6,
26269,
12737,
5091,
6,
2752,
32836,
5091,
6,
427,
766,
66,
285,
33510,
5091,
6,
2207,
348,
5895,
5091,
6,
12010,
40988,
5091,
6,
27818,
1291,
5895,
5091,
6,
3506,
43405,
3075,
2456,
6,
3506,
6320,
787,
2131,
272,
273,
253,
4808,
2456,
6,
5192,
570,
2456,
6,
1780,
394,
1544,
45795,
2456,
6,
443,
1942,
26744,
2456,
6,
443,
24157,
19850,
30415,
2456,
6,
18402,
532,
1851,
571,
16,
3296,
532,
4420,
261,
2456,
6,
14540,
9522,
49429,
2456,
6,
4410,
5504,
14099,
16,
8259,
2035,
2456,
6,
596,
41707,
2689,
282,
2713,
261,
2456,
6,
3506,
6320,
25874,
11421,
7871,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
22678,
11059,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
990,
10676,
1514,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
46205,
11059,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
46394,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
35675,
472,
1514,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
2318,
5650,
818,
15,
22,
6,
743,
410,
36592,
818,
15,
22,
6,
1780,
350,
451,
34029,
818,
15,
22,
6,
329,
339,
13683,
21467,
818,
15,
22,
6,
12441,
274,
514,
818,
15,
22,
6,
330,
11892,
11887,
24031,
818,
15,
22,
6,
36527,
552,
12235,
2728,
818,
15,
22,
6,
330,
29379,
11083,
45050,
818,
15,
22,
6,
9753,
267,
9077,
818,
15,
22,
6,
3035,
25088,
5895,
818,
15,
22,
6,
35230,
9457,
818,
15,
22,
6,
4051,
8056,
335,
15819,
818,
15,
22,
6,
18402,
412,
555,
5114,
818,
15,
22,
6,
25411,
709,
1591,
571,
818,
15,
22,
6,
496,
29309,
1515,
818,
15,
22,
6,
32483,
41244,
3473,
818,
15,
22,
6,
27831,
255,
16033,
75,
10593,
400,
5895,
256,
280,
6357,
818,
15,
22,
6,
49684,
12670,
15819,
818,
15,
22,
6,
5979,
47119,
818,
15,
22,
6,
21688,
15151,
818,
15,
22,
6,
2752,
375,
5895,
818,
15,
22,
6,
49561,
675,
5895,
818,
15,
22,
6,
367,
4885,
19257,
818,
15,
22,
6,
18371,
570,
8177,
7822,
818,
15,
22,
6,
26386,
10803,
37165,
1204,
818,
15,
22,
6,
26386,
10803,
23608,
684,
818,
15,
22,
6,
12751,
267,
39975,
818,
15,
22,
6,
6724,
249,
15819,
818,
15,
22,
6,
6724,
287,
9705,
2009,
26961,
5723,
5895,
818,
15,
22,
6,
1023,
478,
980,
818,
15,
22,
6,
33119,
257,
485,
72,
5242,
818,
15,
22,
6,
26745,
15973,
818,
15,
22,
6,
17633,
15151,
818,
15,
22,
6,
27021,
2957,
818,
15,
22,
6,
1219,
80,
1553,
571,
403,
682,
428,
775,
8885,
7262,
46999,
428,
35783,
301,
1105,
5895,
428,
444,
610,
783,
785,
428,
2588,
1562,
44623,
428,
309,
6992,
6711,
498,
5895,
428,
309,
13825,
428,
7854,
902,
1430,
428,
36999,
27622,
428,
6053,
71,
5660,
18364,
2689,
282,
2713,
261,
428,
380,
8801,
34689,
5174,
15195,
1497,
313,
41,
5964,
10,
556,
5728,
1491,
327,
849,
2223,
247,
861,
390,
19831,
6634,
275,
247,
1617,
15,
18770,
273,
436,
1491,
3249,
432,
2207,
15671,
292,
13,
247,
5284,
7520,
2728,
5447,
15,
380,
4294,
273,
247,
861,
390,
19831,
310,
3798,
7117,
347,
247,
7227,
6642,
273,
253,
7155,
273,
1363,
665,
452,
326,
4735,
15,
380,
4294,
778,
671,
320,
7117,
347,
247,
6919,
15,
380,
806,
1180,
273,
253,
6919,
310,
849,
1142,
952,
574,
253,
19831,
13,
285,
253,
1273,
1180,
310,
253,
2264,
1180,
273,
952,
665,
497,
6730,
275,
581,
1263,
15,
1198,
1650,
13,
247,
4294,
273,
2030,
16,
1099,
2097,
326,
275,
247,
1263,
273,
2030,
952,
512,
1363,
497,
1119,
281,
452,
326,
19831,
15,
4923,
841,
11383,
403,
1754,
327,
247,
2173,
1263,
13,
253,
17711,
778,
320,
1027,
604,
1529,
1387,
273,
1363,
403,
6730,
15,
13168,
13,
642,
1491,
327,
4294,
310,
2130,
15,
496,
841,
2219,
13,
253,
861,
390,
19831,
778,
320,
7520,
390,
1846,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
403,
253,
5917,
273,
2325,
31728,
292,
434,
2728,
3736,
1276,
403,
253,
7871,
285,
5917,
273,
2325,
31728,
292,
434,
2728,
32,
40561,
3056,
273,
2325,
31728,
292,
434,
2728,
2486,
18902,
44623,
275,
253,
6208,
313,
250,
35128,
476,
6426,
594,
373,
10,
285,
327,
253,
730,
32421,
13,
285,
5130,
10696,
313,
48132,
5895,
481,
380,
8984,
778,
671,
2847,
2710,
3510,
273,
4808,
10429,
13,
21781,
13,
25211,
10696,
13,
30091,
5895,
313,
11006,
9862,
273,
253,
15403,
273,
253,
3998,
285,
14472,
12045,
582,
285,
45752,
11083,
39839,
447,
15,
2325,
31728,
292,
434,
310,
247,
4471,
14,
10394,
2728,
28,
352,
778,
6388,
512,
15384,
285,
2818,
253,
4275,
11219,
985,
13,
8479,
3541,
2957,
285,
15506,
6519,
13,
6654,
13,
285,
4866,
15,
380,
2538,
273,
253,
2728,
778,
2486,
44868,
13,
9980,
13,
25567,
273,
253,
14472,
12045,
13,
285,
16356,
10552,
15,
380,
8801,
34689,
5174,
15195,
1497,
3400,
253,
1563,
1618,
273,
7871,
285,
5917,
323,
2325,
31728,
292,
434,
2728,
15,
1310,
253,
1491,
310,
2130,
13,
253,
2829,
2708,
3797,
849,
2223,
253,
19831,
310,
2326,
275,
952,
342,
436,
1617,
15,
1422,
476,
897,
253,
3050,
1282,
25263,
8710,
26372,
281,
1007,
598,
253,
14308,
323,
841,
3739,
2426,
15,
8714,
84,
285,
40561,
3056,
17274,
13954,
1180,
273,
1363,
313,
9453,
2130,
10,
3506,
12850,
1319,
273,
3276,
7248,
5091,
6,
1780,
394,
13825,
5091,
6,
353,
2980,
5895,
5091,
6,
26269,
12737,
5091,
6,
2752,
32836,
5091,
6,
427,
766,
66,
285,
33510,
5091,
6,
2207,
348,
5895,
5091,
6,
12010,
40988,
5091,
6,
27818,
1291,
5895,
5091,
6,
3506,
43405,
3075,
2456,
6,
3506,
6320,
787,
2131,
272,
273,
253,
4808,
2456,
6,
5192,
570,
2456,
6,
1780,
394,
1544,
45795,
2456,
6,
443,
1942,
26744,
2456,
6,
443,
24157,
19850,
30415,
2456,
6,
18402,
532,
1851,
571,
16,
3296,
532,
4420,
261,
2456,
6,
14540,
9522,
49429,
2456,
6,
4410,
5504,
14099,
16,
8259,
2035,
2456,
6,
596,
41707,
2689,
282,
2713,
261,
2456,
6,
3506,
6320,
25874,
11421,
7871,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
22678,
11059,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
990,
10676,
1514,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
46205,
11059,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
46394,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
35675,
472,
1514,
818,
15,
22,
6,
3506,
12850,
1319,
273,
253,
2318,
5650,
818,
15,
22,
6,
743,
410,
36592,
818,
15,
22,
6,
1780,
350,
451,
34029,
818,
15,
22,
6,
329,
339,
13683,
21467,
818,
15,
22,
6,
12441,
274,
514,
818,
15,
22,
6,
330,
11892,
11887,
24031,
818,
15,
22,
6,
36527,
552,
12235,
2728,
818,
15,
22,
6,
330,
29379,
11083,
45050,
818,
15,
22,
6,
9753,
267,
9077,
818,
15,
22,
6,
3035,
25088,
5895,
818,
15,
22,
6,
35230,
9457,
818,
15,
22,
6,
4051,
8056,
335,
15819,
818,
15,
22,
6,
18402,
412,
555,
5114,
818,
15,
22,
6,
25411,
709,
1591,
571,
818,
15,
22,
6,
496,
29309,
1515,
818,
15,
22,
6,
32483,
41244,
3473,
818,
15,
22,
6,
27831,
255,
16033,
75,
10593,
400,
5895,
256,
280,
6357,
818,
15,
22,
6,
49684,
12670,
15819,
818,
15,
22,
6,
5979,
47119,
818,
15,
22,
6,
21688,
15151,
818,
15,
22,
6,
2752,
375,
5895,
818,
15,
22,
6,
49561,
675,
5895,
818,
15,
22,
6,
367,
4885,
19257,
818,
15,
22,
6,
18371,
570,
8177,
7822,
818,
15,
22,
6,
26386,
10803,
37165,
1204,
818,
15,
22,
6,
26386,
10803,
23608,
684,
818,
15,
22,
6,
12751,
267,
39975,
818,
15,
22,
6,
6724,
249,
15819,
818,
15,
22,
6,
6724,
287,
9705,
2009,
26961,
5723,
5895,
818,
15,
22,
6,
1023,
478,
980,
818,
15,
22,
6,
33119,
257,
485,
72,
5242,
818,
15,
22,
6,
26745,
15973,
818,
15,
22,
6,
17633,
15151,
818,
15,
22,
6,
27021,
2957,
818,
15,
22,
6,
1219,
80,
1553,
571,
403,
682,
428,
775,
8885,
7262,
46999,
428,
35783,
301,
1105,
5895,
428,
444,
610,
783,
785,
428,
2588,
1562,
44623,
428,
309,
6992,
6711,
498,
5895,
428,
309,
13825,
428,
7854,
902,
1430,
428,
36999,
27622,
428,
6053,
71,
5660,
18364,
2689,
282,
2713,
261,
428,
380,
8801,
34689,
5174,
15195,
1497,
313,
41,
5964,
10,
556,
5728,
1491,
327,
849,
2223,
247,
861,
390,
19831,
6634,
275,
247,
1617,
15,
18770,
273,
436,
1491,
3249,
432,
2207,
15671,
292,
13,
247,
5284,
7520,
2728,
5447,
15,
380,
4294,
273,
247,
861,
390,
19831,
310,
3798,
7117,
347,
247,
7227,
6642,
273,
253,
7155,
273,
1363,
665,
452,
326,
4735,
15,
380,
4294,
778,
671,
320,
7117,
347,
247,
6919,
15,
380,
806,
1180,
273,
253,
6919,
310,
849,
1142,
952,
574,
253,
19831,
13,
285,
253,
1273,
1180,
310,
253,
2264,
1180,
273,
952,
665,
497,
6730,
275,
581,
1263,
15,
1198,
1650,
13,
247,
4294,
273,
2030,
16,
1099,
2097,
326,
275,
247,
1263,
273,
2030,
952,
512,
1363,
497,
1119,
281,
452,
326,
19831,
15,
4923,
841,
11383,
403,
1754,
327,
247,
2173,
1263,
13,
253,
17711,
778,
320,
1027,
604,
1529,
1387,
273,
1363,
403,
6730,
15,
13168,
13,
642,
1491,
327,
4294,
310,
2130,
15,
496,
841,
2219,
13,
253,
861,
390,
19831,
778,
320,
7520,
390,
1846,
15
] |
What causes Ollier disease ? | What causes Ollier disease? The exact cause of Ollier disease is not known. It is usually a sporadic, non-familial disorder, however, in some cases, it may be inherited as an autosomal dominant genetic trait. | [
1276,
5997,
473,
620,
1321,
2728,
3736,
1276,
5997,
473,
620,
1321,
2728,
32,
380,
3242,
2847,
273,
473,
620,
1321,
2728,
310,
417,
1929,
15,
733,
310,
3798,
247,
39631,
13,
1327,
14,
71,
34206,
451,
8984,
13,
2299,
13,
275,
690,
2219,
13,
352,
778,
320,
20265,
347,
271,
48981,
11360,
6380,
18177,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
5997,
473,
620,
1321,
2728,
3736,
1276,
5997,
473,
620,
1321,
2728,
32,
380,
3242,
2847,
273,
473,
620,
1321,
2728,
310,
417,
1929,
15,
733,
310,
3798,
247,
39631,
13,
1327,
14,
71,
34206,
451,
8984,
13,
2299,
13,
275,
690,
2219,
13,
352,
778,
320,
20265,
347,
271,
48981,
11360,
6380,
18177,
15
] |
What is (are) Refsum disease ? | Refsum disease is an inherited condition that causes vision loss, absence of the sense of smell (anosmia), and a variety of other signs and symptoms. The vision loss associated with Refsum disease is caused by an eye disorder called retinitis pigmentosa. This disorder affects the retina, the light-sensitive layer at the back of the eye. Vision loss occurs as the light-sensing cells of the retina gradually deteriorate. The first sign of retinitis pigmentosa is usually a loss of night vision, which often becomes apparent in childhood. Over a period of years, the disease disrupts side (peripheral) vision and may eventually lead to blindness. Vision loss and anosmia are seen in almost everyone with Refsum disease, but other signs and symptoms vary. About one-third of affected individuals are born with bone abnormalities of the hands and feet. Features that appear later in life can include progressive muscle weakness and wasting; poor balance and coordination (ataxia); hearing loss; and dry, scaly skin (ichthyosis). Additionally, some people with Refsum disease develop an abnormal heart rhythm (arrhythmia) and related heart problems that can be life-threatening. | [
1276,
310,
313,
609,
10,
7567,
2204,
2728,
3736,
7676,
2204,
2728,
310,
271,
20265,
1617,
326,
5997,
8113,
2957,
13,
5928,
273,
253,
3282,
273,
13624,
313,
29496,
15604,
582,
285,
247,
5235,
273,
643,
7871,
285,
5917,
15,
50276,
510,
8113,
2957,
2330,
342,
7567,
2204,
2728,
310,
4269,
407,
271,
5130,
8984,
1925,
851,
46999,
30448,
6859,
15,
831,
8984,
11852,
253,
30067,
13,
253,
1708,
14,
19579,
3828,
387,
253,
896,
273,
253,
5130,
15,
29770,
2957,
6634,
347,
253,
1708,
14,
6209,
272,
1341,
273,
253,
30067,
13237,
16528,
366,
15,
380,
806,
861,
273,
851,
46999,
30448,
6859,
310,
3798,
247,
2957,
273,
2360,
8113,
13,
534,
2223,
4916,
5165,
275,
11948,
15,
6061,
247,
2180,
273,
1107,
13,
253,
2728,
13201,
84,
1930,
313,
468,
41762,
10,
8113,
285,
778,
6524,
1421,
281,
44868,
15,
50276,
55,
1297,
2957,
285,
41658,
15604,
403,
2326,
275,
2761,
4130,
342,
7567,
2204,
2728,
13,
533,
643,
7871,
285,
5917,
6889,
15,
11376,
581,
14,
19016,
273,
5876,
4292,
403,
5686,
342,
5961,
19147,
273,
253,
3564,
285,
4669,
15,
29621,
326,
3176,
1996,
275,
1495,
476,
2486,
13439,
6616,
14855,
285,
31160,
28,
4105,
6654,
285,
19915,
313,
682,
36592,
558,
4854,
2957,
28,
285,
6079,
13,
660,
5242,
4808,
313,
11014,
1994,
2433,
481,
9157,
13,
690,
952,
342,
7567,
2204,
2728,
1287,
271,
10969,
2798,
19407,
313,
3298,
14292,
571,
10,
285,
2905,
2798,
3237,
326,
476,
320,
1495,
14,
33897,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
310,
313,
609,
10,
7567,
2204,
2728,
3736,
7676,
2204,
2728,
310,
271,
20265,
1617,
326,
5997,
8113,
2957,
13,
5928,
273,
253,
3282,
273,
13624,
313,
29496,
15604,
582,
285,
247,
5235,
273,
643,
7871,
285,
5917,
15,
50276,
510,
8113,
2957,
2330,
342,
7567,
2204,
2728,
310,
4269,
407,
271,
5130,
8984,
1925,
851,
46999,
30448,
6859,
15,
831,
8984,
11852,
253,
30067,
13,
253,
1708,
14,
19579,
3828,
387,
253,
896,
273,
253,
5130,
15,
29770,
2957,
6634,
347,
253,
1708,
14,
6209,
272,
1341,
273,
253,
30067,
13237,
16528,
366,
15,
380,
806,
861,
273,
851,
46999,
30448,
6859,
310,
3798,
247,
2957,
273,
2360,
8113,
13,
534,
2223,
4916,
5165,
275,
11948,
15,
6061,
247,
2180,
273,
1107,
13,
253,
2728,
13201,
84,
1930,
313,
468,
41762,
10,
8113,
285,
778,
6524,
1421,
281,
44868,
15,
50276,
55,
1297,
2957,
285,
41658,
15604,
403,
2326,
275,
2761,
4130,
342,
7567,
2204,
2728,
13,
533,
643,
7871,
285,
5917,
6889,
15,
11376,
581,
14,
19016,
273,
5876,
4292,
403,
5686,
342,
5961,
19147,
273,
253,
3564,
285,
4669,
15,
29621,
326,
3176,
1996,
275,
1495,
476,
2486,
13439,
6616,
14855,
285,
31160,
28,
4105,
6654,
285,
19915,
313,
682,
36592,
558,
4854,
2957,
28,
285,
6079,
13,
660,
5242,
4808,
313,
11014,
1994,
2433,
481,
9157,
13,
690,
952,
342,
7567,
2204,
2728,
1287,
271,
10969,
2798,
19407,
313,
3298,
14292,
571,
10,
285,
2905,
2798,
3237,
326,
476,
320,
1495,
14,
33897,
15
] |
Who is at risk for Sudden Cardiac Arrest? ? | The risk of sudden cardiac arrest (SCA) increases:
With age
If you are a man. Men are more likely than women to have SCA.
Some studies show that blacksparticularly those with underlying conditions such as diabetes, high blood pressure, heart failure, and chronic kidney disease or certain cardiac findings on tests such as an electrocardiogramhave a higher risk forSCA.
Major Risk Factor
The major risk factor for SCA is coronary heart disease. Most people who have SCA have some degree of coronary heart disease; however, many people may not know that they have coronary heart disease until SCA occurs. Usually their coronary heart disease is silentthat is, it has no signs or symptoms. Because of this, doctors and nurses have not detected it.
Many people who have SCA also have silent, or undiagnosed, heart attacks before sudden cardiac arrest happens. These people have no clear signs of heart attack, and they dont even realize that theyve had one. Read more about coronary heart disease risk factors.
Other Risk Factors
Other risk factors for SCA include:
A personal history of arrhythmias
A personal or family history of SCA or inherited disorders that make you prone toarrhythmias
Drug or alcohol abuse
Heart attack
Heart failure | [
7883,
310,
387,
2495,
323,
14893,
3354,
9858,
14427,
1780,
1120,
32,
3736,
510,
2495,
273,
5982,
10177,
5263,
313,
4061,
34,
10,
5459,
27,
187,
50262,
187,
3378,
2363,
187,
50262,
187,
2042,
368,
403,
247,
637,
15,
9730,
403,
625,
2779,
685,
2255,
281,
452,
322,
4280,
15,
187,
50262,
187,
6080,
2175,
921,
326,
2806,
1033,
435,
21883,
1110,
342,
6944,
2515,
824,
347,
8401,
13,
1029,
2614,
3473,
13,
2798,
4433,
13,
285,
6722,
12333,
2728,
390,
2176,
10177,
4342,
327,
5216,
824,
347,
271,
4640,
41229,
12935,
9802,
247,
2169,
2495,
323,
4061,
34,
15,
187,
50262,
187,
25052,
22887,
16090,
187,
50262,
187,
510,
2201,
2495,
2803,
323,
322,
4280,
310,
14215,
2798,
2728,
15,
5595,
952,
665,
452,
322,
4280,
452,
690,
4248,
273,
14215,
2798,
2728,
28,
2299,
13,
1142,
952,
778,
417,
871,
326,
597,
452,
14215,
2798,
2728,
1919,
322,
4280,
6634,
15,
25683,
616,
14215,
2798,
2728,
310,
11561,
3529,
310,
13,
352,
556,
642,
7871,
390,
5917,
15,
4923,
273,
436,
13,
11576,
285,
16675,
452,
417,
5189,
352,
15,
187,
50262,
187,
10195,
952,
665,
452,
322,
4280,
671,
452,
11561,
13,
390,
3807,
74,
1530,
1700,
13,
2798,
8104,
1078,
5982,
10177,
5263,
6569,
15,
2053,
952,
452,
642,
2590,
7871,
273,
2798,
2983,
13,
285,
597,
13414,
1014,
8968,
326,
597,
306,
574,
581,
15,
6707,
625,
670,
14215,
2798,
2728,
2495,
2616,
15,
187,
50262,
187,
8665,
22887,
38182,
187,
50262,
187,
8665,
2495,
2616,
323,
322,
4280,
2486,
27,
187,
50262,
187,
34,
3367,
2892,
273,
38369,
6358,
187,
50262,
187,
34,
3367,
390,
2021,
2892,
273,
322,
4280,
390,
20265,
9360,
326,
1056,
368,
21291,
281,
3298,
14292,
6358,
187,
50262,
187,
37,
2371,
390,
7665,
7242,
187,
50262,
187,
39430,
2983,
187,
50262,
187,
39430,
4433
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
7883,
310,
387,
2495,
323,
14893,
3354,
9858,
14427,
1780,
1120,
32,
3736,
510,
2495,
273,
5982,
10177,
5263,
313,
4061,
34,
10,
5459,
27,
187,
50262,
187,
3378,
2363,
187,
50262,
187,
2042,
368,
403,
247,
637,
15,
9730,
403,
625,
2779,
685,
2255,
281,
452,
322,
4280,
15,
187,
50262,
187,
6080,
2175,
921,
326,
2806,
1033,
435,
21883,
1110,
342,
6944,
2515,
824,
347,
8401,
13,
1029,
2614,
3473,
13,
2798,
4433,
13,
285,
6722,
12333,
2728,
390,
2176,
10177,
4342,
327,
5216,
824,
347,
271,
4640,
41229,
12935,
9802,
247,
2169,
2495,
323,
4061,
34,
15,
187,
50262,
187,
25052,
22887,
16090,
187,
50262,
187,
510,
2201,
2495,
2803,
323,
322,
4280,
310,
14215,
2798,
2728,
15,
5595,
952,
665,
452,
322,
4280,
452,
690,
4248,
273,
14215,
2798,
2728,
28,
2299,
13,
1142,
952,
778,
417,
871,
326,
597,
452,
14215,
2798,
2728,
1919,
322,
4280,
6634,
15,
25683,
616,
14215,
2798,
2728,
310,
11561,
3529,
310,
13,
352,
556,
642,
7871,
390,
5917,
15,
4923,
273,
436,
13,
11576,
285,
16675,
452,
417,
5189,
352,
15,
187,
50262,
187,
10195,
952,
665,
452,
322,
4280,
671,
452,
11561,
13,
390,
3807,
74,
1530,
1700,
13,
2798,
8104,
1078,
5982,
10177,
5263,
6569,
15,
2053,
952,
452,
642,
2590,
7871,
273,
2798,
2983,
13,
285,
597,
13414,
1014,
8968,
326,
597,
306,
574,
581,
15,
6707,
625,
670,
14215,
2798,
2728,
2495,
2616,
15,
187,
50262,
187,
8665,
22887,
38182,
187,
50262,
187,
8665,
2495,
2616,
323,
322,
4280,
2486,
27,
187,
50262,
187,
34,
3367,
2892,
273,
38369,
6358,
187,
50262,
187,
34,
3367,
390,
2021,
2892,
273,
322,
4280,
390,
20265,
9360,
326,
1056,
368,
21291,
281,
3298,
14292,
6358,
187,
50262,
187,
37,
2371,
390,
7665,
7242,
187,
50262,
187,
39430,
2983,
187,
50262,
187,
39430,
4433
] |
How to diagnose 21-hydroxylase deficiency ? | Is genetic testing for 21-hydroxylase-deficient congenital adrenal hyperplasia available? Yes. Genetic testing of 21-hydroxylase-deficient congenital adrenal hyperplasia is available. In most people with this condition, the genetic test result can be used to predict disease severity. Click here to view a list of laboratories offering CYP21A2 testing. | [
2347,
281,
33901,
3127,
14,
31810,
38578,
14384,
3736,
2513,
6380,
5175,
323,
3127,
14,
31810,
38578,
14,
25652,
28296,
33903,
42127,
2130,
32,
6279,
15,
37003,
5175,
273,
3127,
14,
31810,
38578,
14,
25652,
28296,
33903,
42127,
310,
2130,
15,
496,
954,
952,
342,
436,
1617,
13,
253,
6380,
1071,
906,
476,
320,
908,
281,
3283,
2728,
12147,
15,
15682,
1060,
281,
1859,
247,
1618,
273,
30684,
9159,
27987,
1797,
34,
19,
5175,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
2347,
281,
33901,
3127,
14,
31810,
38578,
14384,
3736,
2513,
6380,
5175,
323,
3127,
14,
31810,
38578,
14,
25652,
28296,
33903,
42127,
2130,
32,
6279,
15,
37003,
5175,
273,
3127,
14,
31810,
38578,
14,
25652,
28296,
33903,
42127,
310,
2130,
15,
496,
954,
952,
342,
436,
1617,
13,
253,
6380,
1071,
906,
476,
320,
908,
281,
3283,
2728,
12147,
15,
15682,
1060,
281,
1859,
247,
1618,
273,
30684,
9159,
27987,
1797,
34,
19,
5175,
15
] |
What is (are) familial lipoprotein lipase deficiency ? | Familial lipoprotein lipase deficiency is an inherited condition that disrupts the normal breakdown of fats in the body, resulting in an increase of certain kinds of fats. People with familial lipoprotein lipase deficiency typically develop signs and symptoms before age 10, with one-quarter showing symptoms by age 1. The first symptom of this condition is usually abdominal pain, which can vary from mild to severe. The abdominal pain is often due to inflammation of the pancreas (pancreatitis). These episodes of pancreatitis begin as sudden (acute) attacks. If left untreated, pancreatitis can develop into a chronic condition that can damage the pancreas and, in rare cases, be life-threatening. Affected individuals may also have an enlarged liver and spleen (hepatosplenomegaly). The higher the levels of fat in the body, the larger the liver and spleen become. As fat levels rise, certain white blood cells called macrophages take in excess fat in an attempt to rid fat from the bloodstream. After taking in fat, the macrophages travel to the liver and spleen, where the fatty cells accumulate. Approximately half of individuals with familial lipoprotein lipase deficiency develop small yellow deposits of fat under the skin called eruptive xanthomas. These fat deposits most commonly appear on the trunk, buttocks, knees, and arms. Eruptive xanthomas are small (about 1 millimeter in diameter), but individual xanthomas can cluster together to form larger patches. They are generally not painful unless exposed to repeated friction or abrasion. Eruptive xanthomas begin to appear when fat intake increases and levels rise; the deposits disappear when fat intake slows and levels decrease. The blood of people with familial lipoprotein lipase deficiency can have a milky appearance due to its high fat content. When fat levels get very high in people with this condition, fats can accumulate in blood vessels in the tissue that lines the back of the eye (the retina). The fat buildup gives this tissue a pale pink appearance when examined (lipemia retinalis). This fat accumulation does not affect vision and will disappear once fats from the diet are reduced and levels in the body decrease. In people with familial lipoprotein lipase deficiency, increased fat levels can also cause neurological features, such as depression, memory loss, and mild intellectual decline (dementia). These problems are remedied when dietary fat levels normalize. | [
1276,
310,
313,
609,
10,
36490,
30823,
5541,
511,
14384,
3736,
39,
34206,
451,
30823,
5541,
511,
14384,
310,
271,
20265,
1617,
326,
13201,
84,
253,
2622,
19501,
273,
39100,
275,
253,
2133,
13,
4795,
275,
271,
2572,
273,
2176,
9351,
273,
39100,
15,
50276,
8836,
342,
36490,
30823,
5541,
511,
14384,
5431,
1287,
7871,
285,
5917,
1078,
2363,
884,
13,
342,
581,
14,
35443,
4645,
5917,
407,
2363,
337,
15,
380,
806,
19831,
273,
436,
1617,
310,
3798,
17322,
3075,
13,
534,
476,
6889,
432,
11134,
281,
5460,
15,
380,
17322,
3075,
310,
2223,
1955,
281,
10696,
273,
253,
35142,
313,
81,
1377,
675,
5895,
481,
2053,
13305,
273,
15947,
5895,
3135,
347,
5982,
313,
31738,
10,
8104,
15,
1310,
1669,
20716,
13,
15947,
5895,
476,
1287,
715,
247,
6722,
1617,
326,
476,
4723,
253,
35142,
285,
13,
275,
7520,
2219,
13,
320,
1495,
14,
33897,
15,
50276,
34,
21494,
4292,
778,
671,
452,
271,
28148,
6728,
285,
26528,
313,
248,
4066,
375,
446,
257,
485,
72,
5242,
481,
380,
2169,
253,
2308,
273,
4688,
275,
253,
2133,
13,
253,
4067,
253,
6728,
285,
26528,
2489,
15,
1284,
4688,
2308,
6054,
13,
2176,
3168,
2614,
1341,
1925,
15431,
1379,
275,
6714,
4688,
275,
271,
3177,
281,
8314,
4688,
432,
253,
2614,
4963,
15,
2732,
3192,
275,
4688,
13,
253,
15431,
4288,
281,
253,
6728,
285,
26528,
13,
835,
253,
14126,
1341,
29010,
15,
50276,
30305,
21026,
2716,
273,
4292,
342,
36490,
30823,
5541,
511,
14384,
1287,
1355,
8862,
22413,
273,
4688,
762,
253,
4808,
1925,
30900,
422,
1269,
14718,
4921,
15,
2053,
4688,
22413,
954,
7744,
3176,
327,
253,
18855,
13,
11566,
4121,
13,
15746,
13,
285,
6174,
15,
444,
3787,
422,
1269,
14718,
4921,
403,
1355,
313,
10383,
337,
5499,
17121,
275,
9080,
582,
533,
2060,
1269,
14718,
4921,
476,
7368,
2366,
281,
830,
4067,
20412,
15,
1583,
403,
3839,
417,
16592,
5734,
7329,
281,
6015,
20636,
390,
490,
83,
4930,
15,
444,
3787,
422,
1269,
14718,
4921,
3135,
281,
3176,
672,
4688,
10820,
5459,
285,
2308,
6054,
28,
253,
22413,
15529,
672,
4688,
10820,
49133,
285,
2308,
6379,
15,
50276,
510,
2614,
273,
952,
342,
36490,
30823,
5541,
511,
14384,
476,
452,
247,
2301,
4742,
7286,
1955,
281,
697,
1029,
4688,
2600,
15,
2091,
4688,
2308,
755,
1077,
1029,
275,
952,
342,
436,
1617,
13,
39100,
476,
29010,
275,
2614,
12671,
275,
253,
4408,
326,
3104,
253,
896,
273,
253,
5130,
313,
783,
30067,
481,
380,
4688,
1973,
484,
4245,
436,
4408,
247,
14530,
14863,
7286,
672,
6730,
313,
20844,
9512,
22043,
261,
481,
831,
4688,
12037,
1057,
417,
2818,
8113,
285,
588,
15529,
2378,
39100,
432,
253,
6196,
403,
3777,
285,
2308,
275,
253,
2133,
6379,
15,
50276,
688,
952,
342,
36490,
30823,
5541,
511,
14384,
13,
2559,
4688,
2308,
476,
671,
2847,
20967,
3386,
13,
824,
347,
9454,
13,
3541,
2957,
13,
285,
11134,
12720,
10343,
313,
69,
19914,
481,
2053,
3237,
403,
16733,
728,
672,
15048,
4688,
2308,
39142,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
310,
313,
609,
10,
36490,
30823,
5541,
511,
14384,
3736,
39,
34206,
451,
30823,
5541,
511,
14384,
310,
271,
20265,
1617,
326,
13201,
84,
253,
2622,
19501,
273,
39100,
275,
253,
2133,
13,
4795,
275,
271,
2572,
273,
2176,
9351,
273,
39100,
15,
50276,
8836,
342,
36490,
30823,
5541,
511,
14384,
5431,
1287,
7871,
285,
5917,
1078,
2363,
884,
13,
342,
581,
14,
35443,
4645,
5917,
407,
2363,
337,
15,
380,
806,
19831,
273,
436,
1617,
310,
3798,
17322,
3075,
13,
534,
476,
6889,
432,
11134,
281,
5460,
15,
380,
17322,
3075,
310,
2223,
1955,
281,
10696,
273,
253,
35142,
313,
81,
1377,
675,
5895,
481,
2053,
13305,
273,
15947,
5895,
3135,
347,
5982,
313,
31738,
10,
8104,
15,
1310,
1669,
20716,
13,
15947,
5895,
476,
1287,
715,
247,
6722,
1617,
326,
476,
4723,
253,
35142,
285,
13,
275,
7520,
2219,
13,
320,
1495,
14,
33897,
15,
50276,
34,
21494,
4292,
778,
671,
452,
271,
28148,
6728,
285,
26528,
313,
248,
4066,
375,
446,
257,
485,
72,
5242,
481,
380,
2169,
253,
2308,
273,
4688,
275,
253,
2133,
13,
253,
4067,
253,
6728,
285,
26528,
2489,
15,
1284,
4688,
2308,
6054,
13,
2176,
3168,
2614,
1341,
1925,
15431,
1379,
275,
6714,
4688,
275,
271,
3177,
281,
8314,
4688,
432,
253,
2614,
4963,
15,
2732,
3192,
275,
4688,
13,
253,
15431,
4288,
281,
253,
6728,
285,
26528,
13,
835,
253,
14126,
1341,
29010,
15,
50276,
30305,
21026,
2716,
273,
4292,
342,
36490,
30823,
5541,
511,
14384,
1287,
1355,
8862,
22413,
273,
4688,
762,
253,
4808,
1925,
30900,
422,
1269,
14718,
4921,
15,
2053,
4688,
22413,
954,
7744,
3176,
327,
253,
18855,
13,
11566,
4121,
13,
15746,
13,
285,
6174,
15,
444,
3787,
422,
1269,
14718,
4921,
403,
1355,
313,
10383,
337,
5499,
17121,
275,
9080,
582,
533,
2060,
1269,
14718,
4921,
476,
7368,
2366,
281,
830,
4067,
20412,
15,
1583,
403,
3839,
417,
16592,
5734,
7329,
281,
6015,
20636,
390,
490,
83,
4930,
15,
444,
3787,
422,
1269,
14718,
4921,
3135,
281,
3176,
672,
4688,
10820,
5459,
285,
2308,
6054,
28,
253,
22413,
15529,
672,
4688,
10820,
49133,
285,
2308,
6379,
15,
50276,
510,
2614,
273,
952,
342,
36490,
30823,
5541,
511,
14384,
476,
452,
247,
2301,
4742,
7286,
1955,
281,
697,
1029,
4688,
2600,
15,
2091,
4688,
2308,
755,
1077,
1029,
275,
952,
342,
436,
1617,
13,
39100,
476,
29010,
275,
2614,
12671,
275,
253,
4408,
326,
3104,
253,
896,
273,
253,
5130,
313,
783,
30067,
481,
380,
4688,
1973,
484,
4245,
436,
4408,
247,
14530,
14863,
7286,
672,
6730,
313,
20844,
9512,
22043,
261,
481,
831,
4688,
12037,
1057,
417,
2818,
8113,
285,
588,
15529,
2378,
39100,
432,
253,
6196,
403,
3777,
285,
2308,
275,
253,
2133,
6379,
15,
50276,
688,
952,
342,
36490,
30823,
5541,
511,
14384,
13,
2559,
4688,
2308,
476,
671,
2847,
20967,
3386,
13,
824,
347,
9454,
13,
3541,
2957,
13,
285,
11134,
12720,
10343,
313,
69,
19914,
481,
2053,
3237,
403,
16733,
728,
672,
15048,
4688,
2308,
39142,
15
] |
What is (are) Glucose transporter type 1 deficiency syndrome ? | Glucose transporter type 1 deficiency syndrome (GLUT1 deficiency syndrome) is an inherited condition that affects the nervous system. Signs and symptoms generally develop within the first few months of life and may include recurrent seizures (epilepsy) and involuntary eye movements. Affected people may also have microcephaly (unusually small head size) that develops after birth, developmental delay, intellectual disability and other neurological problems such as spasticity, ataxia (difficulty coordinating movements), and dysarthria. Approximately 10% of affected people have the "non-epileptic" form of GLUT1 deficiency syndrome which is associated with all the typical symptoms of the condition without seizures. GLUT1 deficiency syndrome is caused by changes (mutations) in the SLC2A1 gene and is inherited in an autosomal dominant manner. Although there is currently no cure for GLUT1 deficiency syndrome, a special diet (called a ketogenic diet) may help alleviate symptoms. | [
1276,
310,
313,
609,
10,
4051,
44612,
29362,
1511,
337,
14384,
9237,
3736,
9030,
44612,
29362,
1511,
337,
14384,
9237,
313,
5990,
3329,
18,
14384,
9237,
10,
310,
271,
20265,
1617,
326,
11852,
253,
11219,
985,
15,
8714,
84,
285,
5917,
3839,
1287,
1561,
253,
806,
1643,
2607,
273,
1495,
285,
778,
2486,
18902,
26347,
313,
554,
587,
19060,
10,
285,
35393,
5130,
11438,
15,
329,
21494,
952,
778,
671,
452,
2494,
336,
545,
5242,
313,
328,
27978,
1355,
1481,
1979,
10,
326,
24357,
846,
4201,
13,
16743,
5778,
13,
12720,
12564,
285,
643,
20967,
3237,
824,
347,
653,
3258,
414,
13,
387,
991,
571,
313,
38157,
90,
45415,
11438,
582,
285,
7915,
5401,
5182,
15,
36242,
884,
6,
273,
5876,
952,
452,
253,
346,
4160,
14,
554,
587,
13683,
3,
830,
273,
9653,
3329,
18,
14384,
9237,
534,
310,
2330,
342,
512,
253,
6867,
5917,
273,
253,
1617,
1293,
26347,
15,
9653,
3329,
18,
14384,
9237,
310,
4269,
407,
2544,
313,
10082,
569,
10,
275,
253,
322,
7988,
19,
34,
18,
3320,
285,
310,
20265,
275,
271,
48981,
11360,
5133,
15,
4129,
627,
310,
4390,
642,
16498,
323,
9653,
3329,
18,
14384,
9237,
13,
247,
2714,
6196,
313,
8890,
247,
23792,
7736,
6196,
10,
778,
1361,
33623,
5917,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
310,
313,
609,
10,
4051,
44612,
29362,
1511,
337,
14384,
9237,
3736,
9030,
44612,
29362,
1511,
337,
14384,
9237,
313,
5990,
3329,
18,
14384,
9237,
10,
310,
271,
20265,
1617,
326,
11852,
253,
11219,
985,
15,
8714,
84,
285,
5917,
3839,
1287,
1561,
253,
806,
1643,
2607,
273,
1495,
285,
778,
2486,
18902,
26347,
313,
554,
587,
19060,
10,
285,
35393,
5130,
11438,
15,
329,
21494,
952,
778,
671,
452,
2494,
336,
545,
5242,
313,
328,
27978,
1355,
1481,
1979,
10,
326,
24357,
846,
4201,
13,
16743,
5778,
13,
12720,
12564,
285,
643,
20967,
3237,
824,
347,
653,
3258,
414,
13,
387,
991,
571,
313,
38157,
90,
45415,
11438,
582,
285,
7915,
5401,
5182,
15,
36242,
884,
6,
273,
5876,
952,
452,
253,
346,
4160,
14,
554,
587,
13683,
3,
830,
273,
9653,
3329,
18,
14384,
9237,
534,
310,
2330,
342,
512,
253,
6867,
5917,
273,
253,
1617,
1293,
26347,
15,
9653,
3329,
18,
14384,
9237,
310,
4269,
407,
2544,
313,
10082,
569,
10,
275,
253,
322,
7988,
19,
34,
18,
3320,
285,
310,
20265,
275,
271,
48981,
11360,
5133,
15,
4129,
627,
310,
4390,
642,
16498,
323,
9653,
3329,
18,
14384,
9237,
13,
247,
2714,
6196,
313,
8890,
247,
23792,
7736,
6196,
10,
778,
1361,
33623,
5917,
15
] |
What is (are) Parasites - Cysticercosis ? | Cysticercosis is an infection caused by the larvae of the parasite Taenia solium. This infection occurs after a person swallows tapeworm eggs. The larvae get into tissues such as muscle and brain, and form cysts there (these are called cysticerci). When cysts are found in the brain, the condition is called neurocysticercosis. | [
1276,
310,
313,
609,
10,
2956,
284,
3254,
428,
330,
9207,
280,
2269,
2433,
3736,
36,
9207,
280,
2269,
2433,
310,
271,
5066,
4269,
407,
253,
23844,
273,
253,
25027,
15543,
23364,
1220,
1514,
15,
50276,
1552,
5066,
6634,
846,
247,
1436,
1863,
42905,
11173,
36141,
11624,
15,
380,
23844,
755,
715,
7944,
824,
347,
6616,
285,
3998,
13,
285,
830,
41578,
627,
313,
20513,
403,
1925,
37194,
2269,
74,
481,
2091,
41578,
403,
1119,
275,
253,
3998,
13,
253,
1617,
310,
1925,
6551,
951,
11224,
2269,
2433,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
310,
313,
609,
10,
2956,
284,
3254,
428,
330,
9207,
280,
2269,
2433,
3736,
36,
9207,
280,
2269,
2433,
310,
271,
5066,
4269,
407,
253,
23844,
273,
253,
25027,
15543,
23364,
1220,
1514,
15,
50276,
1552,
5066,
6634,
846,
247,
1436,
1863,
42905,
11173,
36141,
11624,
15,
380,
23844,
755,
715,
7944,
824,
347,
6616,
285,
3998,
13,
285,
830,
41578,
627,
313,
20513,
403,
1925,
37194,
2269,
74,
481,
2091,
41578,
403,
1119,
275,
253,
3998,
13,
253,
1617,
310,
1925,
6551,
951,
11224,
2269,
2433,
15
] |
Is hypophosphatasia inherited ? | The severe forms of hypophosphatasia that appear early in life are inherited in an autosomal recessive pattern. Autosomal recessive inheritance means that two copies of the gene in each cell are altered. Most often, the parents of an individual with an autosomal recessive disorder each carry one copy of the altered gene but do not show signs and symptoms of the disorder. Milder forms of hypophosphatasia can have either an autosomal recessive or an autosomal dominant pattern of inheritance. Autosomal dominant inheritance means that one copy of the altered gene in each cell is sufficient to cause the disorder. | [
2513,
3500,
25982,
255,
13411,
20265,
3736,
510,
5460,
4948,
273,
3500,
25982,
255,
13411,
326,
3176,
2393,
275,
1495,
403,
20265,
275,
271,
48981,
24096,
422,
3102,
15,
5271,
13304,
24096,
422,
24954,
2097,
326,
767,
10125,
273,
253,
3320,
275,
1016,
894,
403,
12059,
15,
5595,
2223,
13,
253,
4651,
273,
271,
2060,
342,
271,
48981,
24096,
422,
8984,
1016,
4459,
581,
3491,
273,
253,
12059,
3320,
533,
513,
417,
921,
7871,
285,
5917,
273,
253,
8984,
15,
50276,
46,
6741,
4948,
273,
3500,
25982,
255,
13411,
476,
452,
2057,
271,
48981,
24096,
422,
390,
271,
48981,
11360,
3102,
273,
24954,
15,
5271,
13304,
11360,
24954,
2097,
326,
581,
3491,
273,
253,
12059,
3320,
275,
1016,
894,
310,
4209,
281,
2847,
253,
8984,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
2513,
3500,
25982,
255,
13411,
20265,
3736,
510,
5460,
4948,
273,
3500,
25982,
255,
13411,
326,
3176,
2393,
275,
1495,
403,
20265,
275,
271,
48981,
24096,
422,
3102,
15,
5271,
13304,
24096,
422,
24954,
2097,
326,
767,
10125,
273,
253,
3320,
275,
1016,
894,
403,
12059,
15,
5595,
2223,
13,
253,
4651,
273,
271,
2060,
342,
271,
48981,
24096,
422,
8984,
1016,
4459,
581,
3491,
273,
253,
12059,
3320,
533,
513,
417,
921,
7871,
285,
5917,
273,
253,
8984,
15,
50276,
46,
6741,
4948,
273,
3500,
25982,
255,
13411,
476,
452,
2057,
271,
48981,
24096,
422,
390,
271,
48981,
11360,
3102,
273,
24954,
15,
5271,
13304,
11360,
24954,
2097,
326,
581,
3491,
273,
253,
12059,
3320,
275,
1016,
894,
310,
4209,
281,
2847,
253,
8984,
15
] |
How many people are affected by Prolactinoma ? | Although small benign pituitary tumors are fairly common in the general population, symptomatic prolactinomas are uncommon. Prolactinomas occur more often in women than men and rarely occur in children. | [
2347,
1142,
952,
403,
5876,
407,
46484,
20050,
3691,
3736,
8430,
1355,
21690,
37804,
8837,
403,
9648,
1846,
275,
253,
2087,
3072,
13,
28387,
27400,
20050,
4921,
403,
24666,
15,
46484,
20050,
4921,
2826,
625,
2223,
275,
2255,
685,
1821,
285,
11766,
2826,
275,
2151,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
2347,
1142,
952,
403,
5876,
407,
46484,
20050,
3691,
3736,
8430,
1355,
21690,
37804,
8837,
403,
9648,
1846,
275,
253,
2087,
3072,
13,
28387,
27400,
20050,
4921,
403,
24666,
15,
46484,
20050,
4921,
2826,
625,
2223,
275,
2255,
685,
1821,
285,
11766,
2826,
275,
2151,
15
] |
What are the treatments for chronic granulomatous disease ? | These resources address the diagnosis or management of chronic granulomatous disease: - American Academy of Allergy, Asthma, and Immunology - Gene Review: Gene Review: Chronic Granulomatous Disease - Genetic Testing Registry: Chronic granulomatous disease, X-linked - Genetic Testing Registry: Chronic granulomatous disease, autosomal recessive cytochrome b-positive, type 1 - Genetic Testing Registry: Chronic granulomatous disease, autosomal recessive cytochrome b-positive, type 2 - Genetic Testing Registry: Chronic granulomatous disease, autosomal recessive cytochrome b-positive, type 3 - Genetic Testing Registry: Granulomatous disease, chronic, autosomal recessive, cytochrome b-negative - MedlinePlus Encyclopedia: Chronic Granulomatous Disease - Primary Immune Deficiency Treatment Consortium These resources from MedlinePlus offer information about the diagnosis and management of various health conditions: - Diagnostic Tests - Drug Therapy - Surgery and Rehabilitation - Genetic Counseling - Palliative Care | [
1276,
403,
253,
9694,
323,
6722,
27439,
16692,
528,
2728,
3736,
6872,
5300,
2953,
253,
6120,
390,
4323,
273,
6722,
27439,
16692,
528,
2728,
27,
50276,
14,
2448,
11417,
273,
1876,
2124,
13,
15123,
14894,
13,
285,
14540,
1497,
50276,
14,
15763,
8439,
27,
15763,
8439,
27,
28289,
22346,
335,
16692,
528,
18742,
50276,
14,
37003,
30750,
38227,
27,
28289,
27439,
16692,
528,
2728,
13,
1594,
14,
16862,
50276,
14,
37003,
30750,
38227,
27,
28289,
27439,
16692,
528,
2728,
13,
48981,
24096,
422,
34956,
270,
14,
10247,
13,
1511,
337,
50276,
14,
37003,
30750,
38227,
27,
28289,
27439,
16692,
528,
2728,
13,
48981,
24096,
422,
34956,
270,
14,
10247,
13,
1511,
374,
50276,
14,
37003,
30750,
38227,
27,
28289,
27439,
16692,
528,
2728,
13,
48981,
24096,
422,
34956,
270,
14,
10247,
13,
1511,
495,
50276,
14,
37003,
30750,
38227,
27,
22346,
335,
16692,
528,
2728,
13,
6722,
13,
48981,
24096,
422,
13,
34956,
270,
14,
12373,
50276,
14,
3050,
1282,
25263,
43338,
27,
28289,
22346,
335,
16692,
528,
18742,
50276,
14,
20988,
14540,
70,
3366,
24485,
17012,
42849,
50275,
6872,
5300,
432,
3050,
1282,
25263,
3959,
1491,
670,
253,
6120,
285,
4323,
273,
2710,
1786,
2515,
27,
50276,
14,
44194,
32503,
50276,
14,
16686,
34294,
50276,
14,
34621,
285,
49251,
50276,
14,
37003,
19330,
272,
50275,
14,
42745,
18168,
9776
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
403,
253,
9694,
323,
6722,
27439,
16692,
528,
2728,
3736,
6872,
5300,
2953,
253,
6120,
390,
4323,
273,
6722,
27439,
16692,
528,
2728,
27,
50276,
14,
2448,
11417,
273,
1876,
2124,
13,
15123,
14894,
13,
285,
14540,
1497,
50276,
14,
15763,
8439,
27,
15763,
8439,
27,
28289,
22346,
335,
16692,
528,
18742,
50276,
14,
37003,
30750,
38227,
27,
28289,
27439,
16692,
528,
2728,
13,
1594,
14,
16862,
50276,
14,
37003,
30750,
38227,
27,
28289,
27439,
16692,
528,
2728,
13,
48981,
24096,
422,
34956,
270,
14,
10247,
13,
1511,
337,
50276,
14,
37003,
30750,
38227,
27,
28289,
27439,
16692,
528,
2728,
13,
48981,
24096,
422,
34956,
270,
14,
10247,
13,
1511,
374,
50276,
14,
37003,
30750,
38227,
27,
28289,
27439,
16692,
528,
2728,
13,
48981,
24096,
422,
34956,
270,
14,
10247,
13,
1511,
495,
50276,
14,
37003,
30750,
38227,
27,
22346,
335,
16692,
528,
2728,
13,
6722,
13,
48981,
24096,
422,
13,
34956,
270,
14,
12373,
50276,
14,
3050,
1282,
25263,
43338,
27,
28289,
22346,
335,
16692,
528,
18742,
50276,
14,
20988,
14540,
70,
3366,
24485,
17012,
42849,
50275,
6872,
5300,
432,
3050,
1282,
25263,
3959,
1491,
670,
253,
6120,
285,
4323,
273,
2710,
1786,
2515,
27,
50276,
14,
44194,
32503,
50276,
14,
16686,
34294,
50276,
14,
34621,
285,
49251,
50276,
14,
37003,
19330,
272,
50275,
14,
42745,
18168,
9776
] |
what research (or clinical trials) is being done for Post-Polio Syndrome ? | The National Institute of Neurological Disorders and Stroke (NINDS) and other institutes of the National Institutes of Health (NIH) conduct research related to PPS in laboratories at the NIH, and also support additional PPS research through grants to major medical institutions across the country. | [
5371,
2561,
313,
263,
3382,
7587,
10,
310,
1146,
2218,
323,
5779,
14,
7638,
900,
39365,
3736,
510,
3313,
6516,
273,
29459,
36083,
49566,
285,
659,
7292,
313,
47,
1042,
5942,
10,
285,
643,
4969,
2279,
273,
253,
3313,
31935,
273,
4775,
313,
13652,
41,
10,
2589,
2561,
2905,
281,
367,
3299,
275,
30684,
387,
253,
28569,
13,
285,
671,
1329,
3081,
367,
3299,
2561,
949,
16311,
281,
2201,
3739,
10003,
2439,
253,
2586,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
5371,
2561,
313,
263,
3382,
7587,
10,
310,
1146,
2218,
323,
5779,
14,
7638,
900,
39365,
3736,
510,
3313,
6516,
273,
29459,
36083,
49566,
285,
659,
7292,
313,
47,
1042,
5942,
10,
285,
643,
4969,
2279,
273,
253,
3313,
31935,
273,
4775,
313,
13652,
41,
10,
2589,
2561,
2905,
281,
367,
3299,
275,
30684,
387,
253,
28569,
13,
285,
671,
1329,
3081,
367,
3299,
2561,
949,
16311,
281,
2201,
3739,
10003,
2439,
253,
2586,
15
] |
What is the outlook for Absence of the Septum Pellucidum ? | When the absence of the septum pellucidum is part of septo-optic dysplasia, the prognosis varies according to the presence and severity of associated symptoms. By itself, absence of the septum pellucidum is not life-threatening. | [
1276,
310,
253,
29338,
323,
16508,
566,
273,
253,
4005,
360,
367,
437,
15912,
360,
3736,
3039,
253,
5928,
273,
253,
22688,
360,
268,
437,
15912,
360,
310,
629,
273,
396,
22352,
14,
37016,
48723,
13,
253,
17102,
16149,
2556,
281,
253,
3361,
285,
12147,
273,
2330,
5917,
15,
2896,
3139,
13,
5928,
273,
253,
22688,
360,
268,
437,
15912,
360,
310,
417,
1495,
14,
33897,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
310,
253,
29338,
323,
16508,
566,
273,
253,
4005,
360,
367,
437,
15912,
360,
3736,
3039,
253,
5928,
273,
253,
22688,
360,
268,
437,
15912,
360,
310,
629,
273,
396,
22352,
14,
37016,
48723,
13,
253,
17102,
16149,
2556,
281,
253,
3361,
285,
12147,
273,
2330,
5917,
15,
2896,
3139,
13,
5928,
273,
253,
22688,
360,
268,
437,
15912,
360,
310,
417,
1495,
14,
33897,
15
] |
Do you have information about Motor Vehicle Safety | Summary : Every year thousands of people in the U.S. die from motor vehicle crashes. Trying to prevent these crashes is one part of motor vehicle safety. Here are some things you can do to be safer on the road: - Make sure your vehicle is safe and in working order - Use car seats for children - Wear your seat belt - Don't speed or drive aggressively - Don't drive impaired Safety also involves being aware of others. Share the road with bicycles and motorcycles, and watch for pedestrians. | [
4045,
368,
452,
1491,
670,
18521,
37614,
18731,
18548,
1163,
6000,
807,
6763,
273,
952,
275,
253,
530,
15,
52,
15,
3150,
432,
5694,
4958,
29212,
15,
47888,
281,
3657,
841,
29212,
310,
581,
629,
273,
5694,
4958,
5252,
15,
3856,
403,
690,
1841,
368,
476,
513,
281,
320,
23107,
327,
253,
3971,
27,
50271,
14,
50276,
13325,
2119,
634,
4958,
310,
4999,
285,
275,
2444,
1340,
50274,
14,
50276,
11244,
1113,
13512,
323,
2151,
50274,
14,
50276,
56,
613,
634,
7319,
13779,
50274,
14,
50276,
5498,
626,
3885,
390,
4446,
39730,
50274,
14,
50276,
5498,
626,
4446,
15506,
50271,
52,
33816,
671,
8687,
1146,
6600,
273,
2571,
15,
20930,
253,
3971,
342,
19151,
5005,
285,
5694,
37360,
13,
285,
3698,
323,
47325,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
4045,
368,
452,
1491,
670,
18521,
37614,
18731,
18548,
1163,
6000,
807,
6763,
273,
952,
275,
253,
530,
15,
52,
15,
3150,
432,
5694,
4958,
29212,
15,
47888,
281,
3657,
841,
29212,
310,
581,
629,
273,
5694,
4958,
5252,
15,
3856,
403,
690,
1841,
368,
476,
513,
281,
320,
23107,
327,
253,
3971,
27,
50271,
14,
50276,
13325,
2119,
634,
4958,
310,
4999,
285,
275,
2444,
1340,
50274,
14,
50276,
11244,
1113,
13512,
323,
2151,
50274,
14,
50276,
56,
613,
634,
7319,
13779,
50274,
14,
50276,
5498,
626,
3885,
390,
4446,
39730,
50274,
14,
50276,
5498,
626,
4446,
15506,
50271,
52,
33816,
671,
8687,
1146,
6600,
273,
2571,
15,
20930,
253,
3971,
342,
19151,
5005,
285,
5694,
37360,
13,
285,
3698,
323,
47325,
15
] |
What is (are) Isolated levocardia ? | Isolated levocardia is a type of situs inversus where the heart is located in the normal position, but there is a mirror-image reversal of other internal organs. Isolated levocardia may occur alone or with heart defects, heart rhythm abnormalities (sick sinus syndrome or atrioventricular node disorder), spleen defects (absent, underdeveloped, or extra spleen), and intestinal malrotation. Long term outlook varies depending on the presence/absence of associated abnormalities, particularly heart defects. The cause of isolated levocardia is not known. It is not usually associated with chromosome abnormalities.[7363] | [
1276,
310,
313,
609,
10,
1680,
35631,
20978,
10676,
571,
3736,
2513,
35631,
20978,
10676,
571,
310,
247,
1511,
273,
1790,
316,
275,
38564,
835,
253,
2798,
310,
4441,
275,
253,
2622,
1899,
13,
533,
627,
310,
247,
11472,
14,
5695,
21080,
273,
643,
4812,
15384,
15,
1680,
35631,
20978,
10676,
571,
778,
2826,
3815,
390,
342,
2798,
12834,
13,
2798,
19407,
19147,
313,
84,
781,
22749,
9237,
390,
387,
363,
729,
290,
13267,
4666,
8984,
582,
26528,
12834,
313,
5375,
290,
13,
762,
35208,
13,
390,
4465,
26528,
582,
285,
16356,
4691,
43151,
15,
8057,
1307,
29338,
16149,
7293,
327,
253,
3361,
16,
5375,
566,
273,
2330,
19147,
13,
3782,
2798,
12834,
15,
380,
2847,
273,
7011,
20978,
10676,
571,
310,
417,
1929,
15,
733,
310,
417,
3798,
2330,
342,
15406,
19147,
4681,
24,
26338,
62
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
310,
313,
609,
10,
1680,
35631,
20978,
10676,
571,
3736,
2513,
35631,
20978,
10676,
571,
310,
247,
1511,
273,
1790,
316,
275,
38564,
835,
253,
2798,
310,
4441,
275,
253,
2622,
1899,
13,
533,
627,
310,
247,
11472,
14,
5695,
21080,
273,
643,
4812,
15384,
15,
1680,
35631,
20978,
10676,
571,
778,
2826,
3815,
390,
342,
2798,
12834,
13,
2798,
19407,
19147,
313,
84,
781,
22749,
9237,
390,
387,
363,
729,
290,
13267,
4666,
8984,
582,
26528,
12834,
313,
5375,
290,
13,
762,
35208,
13,
390,
4465,
26528,
582,
285,
16356,
4691,
43151,
15,
8057,
1307,
29338,
16149,
7293,
327,
253,
3361,
16,
5375,
566,
273,
2330,
19147,
13,
3782,
2798,
12834,
15,
380,
2847,
273,
7011,
20978,
10676,
571,
310,
417,
1929,
15,
733,
310,
417,
3798,
2330,
342,
15406,
19147,
4681,
24,
26338,
62
] |
What are the genetic changes related to erythrokeratodermia variabilis et progressiva ? | EKVP can be caused by mutations in the GJB3 or GJB4 gene. These genes provide instructions for making proteins called connexin 31 and connexin 30.3, respectively. These proteins are part of the connexin family, a group of proteins that form channels called gap junctions on the surface of cells. Gap junctions open and close to regulate the flow of nutrients, charged atoms (ions), and other signaling molecules from one cell to another. They are essential for direct communication between neighboring cells. Gap junctions formed with connexin 31 and connexin 30.3 are found in several tissues, including the outermost layer of skin (the epidermis). The GJB3 and GJB4 gene mutations that cause EKVP alter the structure of the connexins produced from these genes. Studies suggest that the abnormal proteins can build up in a cell structure called the endoplasmic reticulum (ER), triggering a harmful process known as ER stress. Researchers suspect that ER stress damages and leads to the premature death of cells in the epidermis. This cell death leads to skin inflammation, which appears to underlie the development of erythematous areas. The mechanism by which epidermal damage and cell death contributes to hyperkeratosis is poorly understood. In some cases, affected individuals have no identified mutation in the GJB3 or GJB4 gene. In these individuals, the cause of the disorder is unknown. Researchers suspect that changes in other, unidentified genes may also be associated with EKVP. | [
1276,
403,
253,
6380,
2544,
2905,
281,
21564,
287,
6426,
255,
30463,
571,
1459,
5280,
261,
1162,
4780,
9321,
3736,
38,
44,
18355,
476,
320,
4269,
407,
9197,
275,
253,
443,
35941,
20,
390,
443,
35941,
21,
3320,
15,
2053,
3608,
2085,
7997,
323,
2403,
4324,
1925,
1865,
89,
249,
4562,
285,
1865,
89,
249,
1884,
15,
20,
13,
2975,
15,
2053,
4324,
403,
629,
273,
253,
1865,
89,
249,
2021,
13,
247,
1387,
273,
4324,
326,
830,
8123,
1925,
8037,
33138,
327,
253,
2553,
273,
1341,
15,
46096,
33138,
1527,
285,
2810,
281,
14368,
253,
2685,
273,
23491,
13,
6636,
10917,
313,
621,
582,
285,
643,
7601,
8094,
432,
581,
894,
281,
1529,
15,
1583,
403,
5667,
323,
1480,
5511,
875,
20667,
1341,
15,
46096,
33138,
4447,
342,
1865,
89,
249,
4562,
285,
1865,
89,
249,
1884,
15,
20,
403,
1119,
275,
2067,
7944,
13,
1690,
253,
562,
32848,
3828,
273,
4808,
313,
783,
49622,
481,
50276,
510,
443,
35941,
20,
285,
443,
35941,
21,
3320,
9197,
326,
2847,
444,
44,
18355,
6990,
253,
2605,
273,
253,
1865,
89,
968,
4197,
432,
841,
3608,
15,
11709,
1804,
326,
253,
10969,
4324,
476,
1973,
598,
275,
247,
894,
2605,
1925,
253,
990,
36061,
47622,
313,
947,
582,
30444,
247,
19632,
1232,
1929,
347,
7220,
4073,
15,
43133,
9101,
326,
7220,
4073,
8540,
285,
5644,
281,
253,
20346,
2471,
273,
1341,
275,
253,
49622,
15,
831,
894,
2471,
5644,
281,
4808,
10696,
13,
534,
4620,
281,
762,
9114,
253,
2440,
273,
45481,
2056,
528,
3672,
15,
380,
5122,
407,
534,
35371,
4723,
285,
894,
2471,
17904,
281,
4373,
6426,
41272,
310,
15225,
7192,
15,
50276,
688,
690,
2219,
13,
5876,
4292,
452,
642,
3636,
10577,
275,
253,
443,
35941,
20,
390,
443,
35941,
21,
3320,
15,
496,
841,
4292,
13,
253,
2847,
273,
253,
8984,
310,
7202,
15,
43133,
9101,
326,
2544,
275,
643,
13,
39255,
3608,
778,
671,
320,
2330,
342,
444,
44,
18355,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
403,
253,
6380,
2544,
2905,
281,
21564,
287,
6426,
255,
30463,
571,
1459,
5280,
261,
1162,
4780,
9321,
3736,
38,
44,
18355,
476,
320,
4269,
407,
9197,
275,
253,
443,
35941,
20,
390,
443,
35941,
21,
3320,
15,
2053,
3608,
2085,
7997,
323,
2403,
4324,
1925,
1865,
89,
249,
4562,
285,
1865,
89,
249,
1884,
15,
20,
13,
2975,
15,
2053,
4324,
403,
629,
273,
253,
1865,
89,
249,
2021,
13,
247,
1387,
273,
4324,
326,
830,
8123,
1925,
8037,
33138,
327,
253,
2553,
273,
1341,
15,
46096,
33138,
1527,
285,
2810,
281,
14368,
253,
2685,
273,
23491,
13,
6636,
10917,
313,
621,
582,
285,
643,
7601,
8094,
432,
581,
894,
281,
1529,
15,
1583,
403,
5667,
323,
1480,
5511,
875,
20667,
1341,
15,
46096,
33138,
4447,
342,
1865,
89,
249,
4562,
285,
1865,
89,
249,
1884,
15,
20,
403,
1119,
275,
2067,
7944,
13,
1690,
253,
562,
32848,
3828,
273,
4808,
313,
783,
49622,
481,
50276,
510,
443,
35941,
20,
285,
443,
35941,
21,
3320,
9197,
326,
2847,
444,
44,
18355,
6990,
253,
2605,
273,
253,
1865,
89,
968,
4197,
432,
841,
3608,
15,
11709,
1804,
326,
253,
10969,
4324,
476,
1973,
598,
275,
247,
894,
2605,
1925,
253,
990,
36061,
47622,
313,
947,
582,
30444,
247,
19632,
1232,
1929,
347,
7220,
4073,
15,
43133,
9101,
326,
7220,
4073,
8540,
285,
5644,
281,
253,
20346,
2471,
273,
1341,
275,
253,
49622,
15,
831,
894,
2471,
5644,
281,
4808,
10696,
13,
534,
4620,
281,
762,
9114,
253,
2440,
273,
45481,
2056,
528,
3672,
15,
380,
5122,
407,
534,
35371,
4723,
285,
894,
2471,
17904,
281,
4373,
6426,
41272,
310,
15225,
7192,
15,
50276,
688,
690,
2219,
13,
5876,
4292,
452,
642,
3636,
10577,
275,
253,
443,
35941,
20,
390,
443,
35941,
21,
3320,
15,
496,
841,
4292,
13,
253,
2847,
273,
253,
8984,
310,
7202,
15,
43133,
9101,
326,
2544,
275,
643,
13,
39255,
3608,
778,
671,
320,
2330,
342,
444,
44,
18355,
15
] |
Is Rheumatic Fever inherited ? | Is rheumatic fever inherited? Rheumatic fever is likely inherited in a multifactorial manner, which means it is caused by multiple genes interacting with each other and with environmental factors. The condition is thought to occur in genetically susceptible children who are infected with group A Streptococcus bacteria and live in poor social conditions. Some studies suggest that differences in the expression of various genes involved in the immune response may contribute to rheumatic fever susceptibility. | [
2513,
40334,
18266,
401,
972,
20265,
3736,
2513,
23404,
18266,
15198,
20265,
32,
40334,
18266,
15198,
310,
2779,
20265,
275,
247,
25274,
5906,
451,
5133,
13,
534,
2097,
352,
310,
4269,
407,
2709,
3608,
18745,
342,
1016,
643,
285,
342,
6938,
2616,
15,
380,
1617,
310,
1869,
281,
2826,
275,
24663,
16931,
2151,
665,
403,
9813,
342,
1387,
329,
659,
46782,
9574,
285,
3153,
275,
4105,
2675,
2515,
15,
3808,
2175,
1804,
326,
3910,
275,
253,
2048,
273,
2710,
3608,
3206,
275,
253,
7026,
2380,
778,
8162,
281,
23404,
18266,
15198,
16329,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
2513,
40334,
18266,
401,
972,
20265,
3736,
2513,
23404,
18266,
15198,
20265,
32,
40334,
18266,
15198,
310,
2779,
20265,
275,
247,
25274,
5906,
451,
5133,
13,
534,
2097,
352,
310,
4269,
407,
2709,
3608,
18745,
342,
1016,
643,
285,
342,
6938,
2616,
15,
380,
1617,
310,
1869,
281,
2826,
275,
24663,
16931,
2151,
665,
403,
9813,
342,
1387,
329,
659,
46782,
9574,
285,
3153,
275,
4105,
2675,
2515,
15,
3808,
2175,
1804,
326,
3910,
275,
253,
2048,
273,
2710,
3608,
3206,
275,
253,
7026,
2380,
778,
8162,
281,
23404,
18266,
15198,
16329,
15
] |
What is (are) Colorectal Cancer ? | Key Points
- Colorectal cancer is a disease in which malignant (cancer) cells form in the tissues of the colon or the rectum. - Colorectal cancer is the second leading cause of death from cancer in the United States. - Different factors increase or decrease the risk of getting colorectal cancer.
Colorectal cancer is a disease in which malignant (cancer) cells form in the tissues of the colon or the rectum.
The colon and rectum are parts of the body's digestive system. The digestive system removes and processes nutrients (vitamins, minerals, carbohydrates, fats, proteins, and water) from foods and helps pass waste material out of the body. The digestive system is made up of the mouth, throat, esophagus, stomach, and the small and large intestines. The colon (large bowel) is the first part of the large intestine and is about 5 feet long. Together, the rectum and anal canal make up the last part of the large intestine and are 6-8 inches long. The anal canal ends at the anus (the opening of the large intestine to the outside of the body). Cancer that begins in the colon is called colon cancer, and cancer that begins in the rectum is called rectal cancer. Cancer that begins in either of these organs may also be called colorectal cancer. See the following PDQ summaries for more information about colorectal cancer: - Colorectal Cancer Prevention - Colon Cancer Treatment - Rectal Cancer Treatment - Genetics of Colorectal Cancer
Colorectal cancer is the second leading cause of death from cancer in the United States.
The number of new colorectal cancer cases and the number of deaths from colorectal cancer are decreasing a little bit each year. But in adults younger than 50 years, there has been a small increase in the number of new cases each year since 1998. Colorectal cancer is found more often in men than in women. | [
1276,
310,
313,
609,
10,
2065,
21073,
13877,
3736,
4814,
31411,
187,
50258,
14,
2065,
21073,
2923,
310,
247,
2728,
275,
534,
17566,
313,
30366,
10,
1341,
830,
275,
253,
7944,
273,
253,
6769,
390,
253,
9004,
360,
15,
50273,
14,
2065,
21073,
2923,
310,
253,
1273,
4283,
2847,
273,
2471,
432,
2923,
275,
253,
1986,
2077,
15,
50273,
14,
13773,
2616,
2572,
390,
6379,
253,
2495,
273,
2970,
23878,
2923,
15,
187,
50262,
187,
50262,
187,
50258,
2973,
21073,
2923,
310,
247,
2728,
275,
534,
17566,
313,
30366,
10,
1341,
830,
275,
253,
7944,
273,
253,
6769,
390,
253,
9004,
360,
15,
187,
50258,
510,
6769,
285,
9004,
360,
403,
4243,
273,
253,
2133,
434,
36013,
985,
15,
380,
36013,
985,
26586,
285,
4870,
23491,
313,
34490,
31278,
13,
29383,
13,
38401,
13,
39100,
13,
4324,
13,
285,
1824,
10,
432,
12134,
285,
7729,
1509,
8138,
2144,
562,
273,
253,
2133,
15,
380,
36013,
985,
310,
1160,
598,
273,
253,
6208,
13,
13386,
13,
1578,
40345,
13,
12607,
13,
285,
253,
1355,
285,
1781,
540,
383,
1100,
15,
380,
6769,
313,
16374,
25211,
10,
310,
253,
806,
629,
273,
253,
1781,
28741,
285,
310,
670,
608,
4669,
1048,
15,
20058,
13,
253,
9004,
360,
285,
1115,
19913,
1056,
598,
253,
1390,
629,
273,
253,
1781,
28741,
285,
403,
721,
14,
25,
13048,
1048,
15,
380,
1115,
19913,
7637,
387,
253,
271,
316,
313,
783,
5909,
273,
253,
1781,
28741,
281,
253,
3345,
273,
253,
2133,
481,
50272,
5804,
1209,
326,
9513,
275,
253,
6769,
310,
1925,
6769,
2923,
13,
285,
2923,
326,
9513,
275,
253,
9004,
360,
310,
1925,
37263,
2923,
15,
13877,
326,
9513,
275,
2057,
273,
841,
15384,
778,
671,
320,
1925,
23878,
2923,
15,
50275,
5035,
253,
1563,
6442,
50,
14568,
3927,
323,
625,
1491,
670,
23878,
2923,
27,
50269,
14,
50275,
2973,
21073,
13877,
27526,
50273,
14,
50276,
2973,
251,
13877,
17012,
50273,
14,
50276,
17229,
267,
13877,
17012,
50273,
14,
50276,
7475,
11665,
273,
2065,
21073,
13877,
187,
50262,
187,
50262,
187,
50258,
2973,
21073,
2923,
310,
253,
1273,
4283,
2847,
273,
2471,
432,
2923,
275,
253,
1986,
2077,
15,
187,
50258,
510,
1180,
273,
747,
23878,
2923,
2219,
285,
253,
1180,
273,
8923,
432,
23878,
2923,
403,
11052,
247,
1652,
2372,
1016,
807,
15,
1292,
275,
7747,
9243,
685,
2456,
1107,
13,
627,
556,
644,
247,
1355,
2572,
275,
253,
1180,
273,
747,
2219,
1016,
807,
1580,
8065,
15,
2065,
21073,
2923,
310,
1119,
625,
2223,
275,
1821,
685,
275,
2255,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
310,
313,
609,
10,
2065,
21073,
13877,
3736,
4814,
31411,
187,
50258,
14,
2065,
21073,
2923,
310,
247,
2728,
275,
534,
17566,
313,
30366,
10,
1341,
830,
275,
253,
7944,
273,
253,
6769,
390,
253,
9004,
360,
15,
50273,
14,
2065,
21073,
2923,
310,
253,
1273,
4283,
2847,
273,
2471,
432,
2923,
275,
253,
1986,
2077,
15,
50273,
14,
13773,
2616,
2572,
390,
6379,
253,
2495,
273,
2970,
23878,
2923,
15,
187,
50262,
187,
50262,
187,
50258,
2973,
21073,
2923,
310,
247,
2728,
275,
534,
17566,
313,
30366,
10,
1341,
830,
275,
253,
7944,
273,
253,
6769,
390,
253,
9004,
360,
15,
187,
50258,
510,
6769,
285,
9004,
360,
403,
4243,
273,
253,
2133,
434,
36013,
985,
15,
380,
36013,
985,
26586,
285,
4870,
23491,
313,
34490,
31278,
13,
29383,
13,
38401,
13,
39100,
13,
4324,
13,
285,
1824,
10,
432,
12134,
285,
7729,
1509,
8138,
2144,
562,
273,
253,
2133,
15,
380,
36013,
985,
310,
1160,
598,
273,
253,
6208,
13,
13386,
13,
1578,
40345,
13,
12607,
13,
285,
253,
1355,
285,
1781,
540,
383,
1100,
15,
380,
6769,
313,
16374,
25211,
10,
310,
253,
806,
629,
273,
253,
1781,
28741,
285,
310,
670,
608,
4669,
1048,
15,
20058,
13,
253,
9004,
360,
285,
1115,
19913,
1056,
598,
253,
1390,
629,
273,
253,
1781,
28741,
285,
403,
721,
14,
25,
13048,
1048,
15,
380,
1115,
19913,
7637,
387,
253,
271,
316,
313,
783,
5909,
273,
253,
1781,
28741,
281,
253,
3345,
273,
253,
2133,
481,
50272,
5804,
1209,
326,
9513,
275,
253,
6769,
310,
1925,
6769,
2923,
13,
285,
2923,
326,
9513,
275,
253,
9004,
360,
310,
1925,
37263,
2923,
15,
13877,
326,
9513,
275,
2057,
273,
841,
15384,
778,
671,
320,
1925,
23878,
2923,
15,
50275,
5035,
253,
1563,
6442,
50,
14568,
3927,
323,
625,
1491,
670,
23878,
2923,
27,
50269,
14,
50275,
2973,
21073,
13877,
27526,
50273,
14,
50276,
2973,
251,
13877,
17012,
50273,
14,
50276,
17229,
267,
13877,
17012,
50273,
14,
50276,
7475,
11665,
273,
2065,
21073,
13877,
187,
50262,
187,
50262,
187,
50258,
2973,
21073,
2923,
310,
253,
1273,
4283,
2847,
273,
2471,
432,
2923,
275,
253,
1986,
2077,
15,
187,
50258,
510,
1180,
273,
747,
23878,
2923,
2219,
285,
253,
1180,
273,
8923,
432,
23878,
2923,
403,
11052,
247,
1652,
2372,
1016,
807,
15,
1292,
275,
7747,
9243,
685,
2456,
1107,
13,
627,
556,
644,
247,
1355,
2572,
275,
253,
1180,
273,
747,
2219,
1016,
807,
1580,
8065,
15,
2065,
21073,
2923,
310,
1119,
625,
2223,
275,
1821,
685,
275,
2255,
15
] |
What is (are) Syncope ? | Syncope is a medical term used to describe a temporary loss of consciousness due to the sudden decline of blood flow to the brain. Syncope is commonly called fainting or passing out. If an individual is about to faint, he or she will feel dizzy, lightheaded, or nauseous and their field of vision may white out or black out. The skin may be cold and clammy. The person drops to the floor as he or she loses consciousness. After fainting, an individual may be unconscious for a minute or two, but will revive and slowly return to normal. Syncope can occur in otherwise healthy people and affects all age groups, but occurs more often in the elderly.
Vasovagal
Carotid sinus
Situational | [
1276,
310,
313,
609,
10,
322,
6665,
1714,
3736,
27902,
1714,
310,
247,
3739,
1307,
908,
281,
6266,
247,
11287,
2957,
273,
14099,
1955,
281,
253,
5982,
10343,
273,
2614,
2685,
281,
253,
3998,
15,
322,
6665,
1714,
310,
7744,
1925,
46947,
1076,
390,
8136,
562,
15,
1310,
271,
2060,
310,
670,
281,
16487,
13,
344,
390,
703,
588,
1928,
32862,
3847,
13,
1708,
24818,
13,
390,
28237,
528,
285,
616,
1673,
273,
8113,
778,
3168,
562,
390,
2806,
562,
15,
380,
4808,
778,
320,
5412,
285,
35219,
2577,
15,
380,
1436,
15323,
281,
253,
5254,
347,
344,
390,
703,
25068,
14099,
15,
2732,
46947,
1076,
13,
271,
2060,
778,
320,
22382,
323,
247,
7017,
390,
767,
13,
533,
588,
47122,
285,
7808,
1091,
281,
2622,
15,
322,
6665,
1714,
476,
2826,
275,
5010,
5875,
952,
285,
11852,
512,
2363,
2390,
13,
533,
6634,
625,
2223,
275,
253,
13988,
15,
187,
50262,
187,
55,
284,
729,
356,
267,
187,
50262,
187,
10697,
302,
301,
22749,
187,
50262,
187,
35678,
86,
1050
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
310,
313,
609,
10,
322,
6665,
1714,
3736,
27902,
1714,
310,
247,
3739,
1307,
908,
281,
6266,
247,
11287,
2957,
273,
14099,
1955,
281,
253,
5982,
10343,
273,
2614,
2685,
281,
253,
3998,
15,
322,
6665,
1714,
310,
7744,
1925,
46947,
1076,
390,
8136,
562,
15,
1310,
271,
2060,
310,
670,
281,
16487,
13,
344,
390,
703,
588,
1928,
32862,
3847,
13,
1708,
24818,
13,
390,
28237,
528,
285,
616,
1673,
273,
8113,
778,
3168,
562,
390,
2806,
562,
15,
380,
4808,
778,
320,
5412,
285,
35219,
2577,
15,
380,
1436,
15323,
281,
253,
5254,
347,
344,
390,
703,
25068,
14099,
15,
2732,
46947,
1076,
13,
271,
2060,
778,
320,
22382,
323,
247,
7017,
390,
767,
13,
533,
588,
47122,
285,
7808,
1091,
281,
2622,
15,
322,
6665,
1714,
476,
2826,
275,
5010,
5875,
952,
285,
11852,
512,
2363,
2390,
13,
533,
6634,
625,
2223,
275,
253,
13988,
15,
187,
50262,
187,
55,
284,
729,
356,
267,
187,
50262,
187,
10697,
302,
301,
22749,
187,
50262,
187,
35678,
86,
1050
] |
What causes Stevens-Johnson syndrome ? | What causes Stevens-Johnson syndrome? The exact cause of Stevens-Johnson syndrome is unknown in 25 to 30% of cases. In those cases in which the cause can be determined, it is believed to be related to an adverse allergic drug reaction. Almost any drug--but most particularly sulfa drugs--can cause Stevens-Johnson syndrome. The allergic reaction to the drug may not occur until 7-14 days after first using it. Stevens-Johnson syndrome can also be preceded by a viral infection, such as herpes or the mumps. In rare cases, Stevens-Johnson syndrome may be caused by an illness or bone marrow transplantation. | [
1276,
5997,
22801,
14,
32336,
9237,
3736,
1276,
5997,
22801,
14,
32336,
9237,
32,
380,
3242,
2847,
273,
22801,
14,
32336,
9237,
310,
7202,
275,
2030,
281,
1884,
6,
273,
2219,
15,
496,
1110,
2219,
275,
534,
253,
2847,
476,
320,
3413,
13,
352,
310,
6566,
281,
320,
2905,
281,
271,
10021,
26884,
2854,
4884,
15,
24059,
667,
2854,
283,
2858,
954,
3782,
10997,
66,
5835,
283,
5092,
2847,
22801,
14,
32336,
9237,
15,
380,
26884,
4884,
281,
253,
2854,
778,
417,
2826,
1919,
818,
14,
1047,
1897,
846,
806,
970,
352,
15,
22801,
14,
32336,
9237,
476,
671,
320,
29920,
407,
247,
9907,
5066,
13,
824,
347,
42869,
390,
253,
278,
10628,
15,
496,
7520,
2219,
13,
22801,
14,
32336,
9237,
778,
320,
4269,
407,
271,
9749,
390,
5961,
18440,
18061,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
1276,
5997,
22801,
14,
32336,
9237,
3736,
1276,
5997,
22801,
14,
32336,
9237,
32,
380,
3242,
2847,
273,
22801,
14,
32336,
9237,
310,
7202,
275,
2030,
281,
1884,
6,
273,
2219,
15,
496,
1110,
2219,
275,
534,
253,
2847,
476,
320,
3413,
13,
352,
310,
6566,
281,
320,
2905,
281,
271,
10021,
26884,
2854,
4884,
15,
24059,
667,
2854,
283,
2858,
954,
3782,
10997,
66,
5835,
283,
5092,
2847,
22801,
14,
32336,
9237,
15,
380,
26884,
4884,
281,
253,
2854,
778,
417,
2826,
1919,
818,
14,
1047,
1897,
846,
806,
970,
352,
15,
22801,
14,
32336,
9237,
476,
671,
320,
29920,
407,
247,
9907,
5066,
13,
824,
347,
42869,
390,
253,
278,
10628,
15,
496,
7520,
2219,
13,
22801,
14,
32336,
9237,
778,
320,
4269,
407,
271,
9749,
390,
5961,
18440,
18061,
15
] |
Is fragile X-associated primary ovarian insufficiency inherited ? | An increased risk of developing FXPOI is inherited in an X-linked dominant pattern. The FMR1 gene is located on the X chromosome, which is one of the two sex chromosomes. (The Y chromosome is the other sex chromosome.) The inheritance is dominant because one copy of the altered gene in each cell is sufficient to elevate the risk of developing FXPOI. In females (who have two X chromosomes), a mutation in one of the two copies of a gene in each cell can lead to the disorder. However, not all women who inherit an FMR1 premutation will develop FXPOI. Because males do not have ovaries, they are unaffected. | [
2513,
28304,
1594,
14,
12534,
3625,
18984,
39975,
20265,
3736,
1145,
2559,
2495,
273,
6684,
36775,
5964,
42,
310,
20265,
275,
271,
1594,
14,
16862,
11360,
3102,
15,
380,
401,
6784,
18,
3320,
310,
4441,
327,
253,
1594,
15406,
13,
534,
310,
581,
273,
253,
767,
2825,
25112,
15,
313,
510,
714,
15406,
310,
253,
643,
2825,
15406,
2698,
380,
24954,
310,
11360,
984,
581,
3491,
273,
253,
12059,
3320,
275,
1016,
894,
310,
4209,
281,
50181,
253,
2495,
273,
6684,
36775,
5964,
42,
15,
496,
10753,
313,
10002,
452,
767,
1594,
25112,
582,
247,
10577,
275,
581,
273,
253,
767,
10125,
273,
247,
3320,
275,
1016,
894,
476,
1421,
281,
253,
8984,
15,
1723,
13,
417,
512,
2255,
665,
30686,
271,
401,
6784,
18,
5398,
19066,
588,
1287,
36775,
5964,
42,
15,
4923,
10798,
513,
417,
452,
16119,
447,
13,
597,
403,
30195,
15
] | [
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1,
1
] | [
2513,
28304,
1594,
14,
12534,
3625,
18984,
39975,
20265,
3736,
1145,
2559,
2495,
273,
6684,
36775,
5964,
42,
310,
20265,
275,
271,
1594,
14,
16862,
11360,
3102,
15,
380,
401,
6784,
18,
3320,
310,
4441,
327,
253,
1594,
15406,
13,
534,
310,
581,
273,
253,
767,
2825,
25112,
15,
313,
510,
714,
15406,
310,
253,
643,
2825,
15406,
2698,
380,
24954,
310,
11360,
984,
581,
3491,
273,
253,
12059,
3320,
275,
1016,
894,
310,
4209,
281,
50181,
253,
2495,
273,
6684,
36775,
5964,
42,
15,
496,
10753,
313,
10002,
452,
767,
1594,
25112,
582,
247,
10577,
275,
581,
273,
253,
767,
10125,
273,
247,
3320,
275,
1016,
894,
476,
1421,
281,
253,
8984,
15,
1723,
13,
417,
512,
2255,
665,
30686,
271,
401,
6784,
18,
5398,
19066,
588,
1287,
36775,
5964,
42,
15,
4923,
10798,
513,
417,
452,
16119,
447,
13,
597,
403,
30195,
15
] |