In the United States, youth have the highest burden of nonfatal self-inflicted injury (ie, deliberate physical harm against oneself, inclusive of suicidal and nonsuicidal intent) requiring medical attention.1 One study found that emergency department (ED) visits for these injuries during the 1993 to 2008 period varied by age group, ranging from 1.1 to 9.6 per 1000 ED visits, with adolescents aged 15 to 19 years exhibiting the highest rates.1 Self-inflicted injury is one of the strongest risk factors for suicide—the second-leading cause of death among those aged 10 to 24 years during 2015.2 This study examined trends in nonfatal self-inflicted injuries treated in hospital EDs among US children, adolescents, and young adults aged 10 to 24 years (hereafter referred to as youth). 
 
 Methods 
 
 The National Electronic Injury Surveillance System—All Injury Program (NEISS-AIP) collects data on all first-time visits for nonfatal injuries treated in 66 US hospital EDs through stratified probability sampling, allowing for the derivation of national estimates.3 Self-inflicted injuries were identified by reviewing injury cause narratives and other coded data within ED records. This study used publicly available secondary data and was exempted by the CDC from institutional review board review. 
 
 Self-inflicted injury ED visit rates were calculated from 2001 through 2015 by sex, age (10-14, 15-19, and 20-24 years), along with injury method (poisoning, sharp object, blunt object), and 95% CIs using US Census population estimates as denominators. Rates were weighted to obtain nationally representative estimates and age-adjusted to the 2000 US Census population. Trends in self-inflicted injury ED visit rates were assessed using joinpoint regression software (Surveillance Research Program, National Cancer Institute), version 4.3.1.0. The annual percentage change described the rate of change for each linear segment. 
 
 Results 
 
 From 2001 to 2015, NEISS-AIP captured 43 138 youth self-inflicted injury ED visits. The overall weighted age-adjusted rate for this group showed no statistically significant trend until 2008, increasing 5.7% (95% CI, 3.0%-8.4%) annually thereafter and reaching 303.7 per 100 000 population (95% CI, 254.1-353.3) in 2015 (Table). Age-adjusted trends for males overall and across age groups remained stable throughout 2001-2015 (Figure, Table). Overall age-adjusted rates for females demonstrated no statistically significant trend before 2009, yet increased 8.4% (95% CI, 5.6%-11.2%) yearly from 2009 to 2015. After 2009, rates among females aged 10 to 14 years increased 18.8% (95% CI, 12.1%-25.8%) per year—from 109.8 (95% CI, 69.9-149.7) in 2009 to 317.7 (95% CI, 230.3-405.1) per 100 000 population in 2015. Rates among females aged 15 to 19 years showed a 7.2% (95% CI, 3.8%-10.8%) increase per year during 2008-2015. Rates among females aged 20 to 24 years exhibited a 2.0% (95% CI, 0.8%-3.1%) increase per year throughout 2001-2015 (Figure, Table). 
 
 Trends for all self-inflicted injury methods were stable for males. Poisoning was the most common method of self-inflicted injury for females, with rates remaining stable until 2007 and increasing 5.3% (95% CI, 0.5%-10.4%) annually thereafter. Female rates for self-inflicted injuries by sharp object increased 7.1% (95% CI, 5.2%-8.9%) annually throughout 2001-2015; female rates for blunt object injuries were stable during 2006-2015 (Table). 
 
 Discussion 
 
 Youth self-inflicted injury ED visit rates were relatively stable before 2008. However, rates among females significantly increased thereafter—particularly among females aged 10 to 14 years, who experienced an 18.8% annual increase from 2009 to 2015. This study only included ED cases; thus, rates were underestimated. Also, limited statistical power could have resulted in some trends not showing statistical significance. Findings are consistent with previously reported upward trends in youth suicide rates during 1999-2014, in which rates increased most notably after 2006 with females aged 10 to 14 years experiencing the greatest increase.4 Findings also coincide with increased reports of depression among youth, especially young girls.5 Other potential underlying reasons for the observed increasing trends, particularly among young females, warrant further study. 
 
 These findings underscore the need for the implementation of evidence-based, comprehensive suicide and self-harm prevention strategies within health systems and communities. These strategies include strengthening access to and delivery of care for suicidal youth within health systems and creating protective environments, promoting youth connectedness, teaching coping and problem-solving skills, and identifying and supporting at-risk youth within communities.6 
 
 Section Editor: Jody W. Zylke, MD, Deputy Editor. 
 
 Back to top Article Information 
 
 Correction: This article was corrected for an error in the Figure title on December 26, 2017. 
 
 Accepted for Publication: August 16, 2017. 
 
 Corresponding Author: Melissa C. Mercado, PhD, MSc, MA, National Center for Injury Prevention and Control, Centers for Disease Control and Prevention, 4770 Buford Hwy NE, Mailstop F-64, Atlanta, GA 30341-3717 (cju8@cdc.gov). 
 
 Author Contributions: Dr Mercado had full access to all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. 
 
 Concept and design: Mercado, Holland, Leemis, Stone. 
 
 Acquisition, analysis, or interpretation of data: Mercado, Holland, Leemis, Wang. 
 
 Drafting of the manuscript: Mercado, Holland, Leemis, Wang. 
 
 Critical revision of the manuscript for important intellectual content: All authors. 
 
 Statistical analysis: Holland, Wang. 
 
 Administrative, technical, or material support: Mercado, Holland, Leemis. 
 
 Supervision: Mercado. 
 
 Other - subject matter expertise: Stone. 
 
 Conflict of Interest Disclosures: All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest and none were reported. 
 
 Funding/Support: This secondary data analysis study was conducted as part of the regular roles and responsibilities of all coauthors at the Centers for Disease Control and Prevention (CDC). 
 
 Role of the Funder/Sponsor: The CDC was involved in the design and conduct of the study; management, analysis, and interpretation of the data; preparation, review or approval of the manuscript; and decision to submit the manuscript for publication. Data was secondarily analyzed by the CDC, who was not involved in the data collection process. 
 
 Disclaimer: The findings and conclusions in this report are those of the authors and do not necessarily represent the views of the CDC. 
 
 Additional Contributions: The data used in this report originated from the National Electronic Injury Surveillance System All Injury Program, operated by the US Consumer Product Safety Commission and whose data are made available by CDC’s web-based Injury Statistics Query and Reporting System, supported by CDC’s National Center for Injury Prevention and Control. We thank Tadesse Haileyesus, MS (CDC’s National Center for Injury Prevention and Control), for providing technical support. He did not receive compensation for his contribution. 
 
 References ||||| CHICAGO (AP) — Attempted suicides, drug overdoses, cutting and other types of self-injury have increased substantially in U.S. girls, a 15-year study of emergency room visits found. 
 
 It's unclear why, but some mental health experts think cyberbullying, substance abuse and economic stress from the recent recession might be contributing. 
 
 The rising rates "should be of concern to parents, teachers, and pediatricians. One important reason to focus on reducing self-harm is that it is key risk factor for suicide," said Dr. Mark Olfson, a Columbia University psychiatry professor who was not involved in the study. 
 
 The sharpest increase occurred among girls aged 10 to 14, nearly tripling from 2009 to 2015, from about 110 visits per 100,000 to almost 318 per 100,000. 
 
 Older teen girls had the highest rates — 633 visits per 100,000 in 2015, but the increase after 2008 was less steep. 
 
 Drug overdoses and other self-poisonings were the most common method among girls and boys, followed by intentional cutting with sharp objects. The study doesn't include information on which methods were most common by age nor on how many injuries were severe or required hospitalization. 
 
 All the injuries were intentional, but not all were suicide attempts, said lead author Melissa Mercado, a behavioral scientist. 
 
 The study by the U.S. Centers for Disease Control and Prevention was published Tuesday in the Journal of the American Medical Association. The trend parallels rising reports of teen depression and suicide, the researchers noted.. 
 
 The researchers analyzed 2001-2015 data on nonfatal self-inflicted injuries treated in emergency rooms among ages 10 to 24. Nearly 29,000 girls with self-inflicted injuries and about 14,000 boys were treated in emergency rooms during the study years. 
 
 Rates among boys didn't change much during those years. Rates in girls were also stable until around 2008. ER visits for self-injury among young women aged 20 to 24 also increased but at a slower pace, rising from 228 per 100,000 in 2001 to 346 per 100,000 in 2015. 
 
 The results underestimate the problem since they don't include self-injuries treated in doctors' offices or elsewhere, Mercado said. 
 
 Researchers said the findings underscore the need to beef up prevention efforts including finding ways to help at-risk kids feel less isolated and more connected to their peers, and teaching coping and problem-solving skills. 
 
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 Follow Lindsey Tanner on Twitter: @LindseyTanner. Her work can be found here . 
 
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 This story has been updated to correct that only intentional injuries were included in the study.
– Attempted suicides, drug overdoses, cutting, and other types of self-injury have increased substantially in US girls, a 15-year study of ER visits found. It's unclear why, but some mental health experts think cyberbullying, substance abuse, and economic stress from the recent recession might be contributing, the AP reports. The sharpest increase occurred among girls aged 10 to 14, nearly tripling from 2009 to 2015, from about 110 visits per 100,000 to almost 318. Older teen girls had the highest rates—633 visits per 100,000 in 2015, but the increase after 2008 was less steep. The rising rates "should be of concern to parents, teachers, and pediatricians," says Dr. Mark Olfson, a psychiatry professor not involved in the CDC study published in JAMA. "One important reason to focus on reducing self-harm is that it is [a] key risk factor for suicide." Researchers analyzed 2001-2015 data on nonfatal self-inflicted injuries treated in ERs among ages 10 to 24. Nearly 29,000 girls with self-inflicted injuries and about 14,000 boys were treated in ERs during the study years. Rates among boys didn't change much; rates in girls were stable until around 2008. The results underestimate the problem, though, since they don't include self-injuries treated in doctors' offices or elsewhere, says lead author Melissa Mercado. Drug overdoses and other self-poisonings were the most common method for all, followed by intentional cutting with sharp objects. All injuries were intentional, but not all were suicide attempts, says Mercado.