Science Signaling Table of Contents for 4 March 2008; Vol. 1, No. 9 


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Science Signaling, Volume 1, Issue 9  
dated 4 March 2008, is now available at:


http://stke.sciencemag.org/content/vol1/issue9/?etoc













Perspectives

Cyclic NucleotidesMeeting Report: cGMP Matters
Barbara Kemp-Harper and Robert Feil
	Sci. Signal. 1 (9), pe12.  [DOI: 10.1126/stke.19pe12]
	Emerging therapies for treating cardiovascular disorders target the cGMP signaling system.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;1/9/pe12?etoc




Editors' Choice

ChannelsChannel Talk
L. Bryan Ray
	Sci. Signal. 1 (9), ec78.  [DOI: 10.1126/stke.19ec78]
	Two neuronal channel proteins interact and alter each otherâs function.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;1/9/ec78?etoc

ImmunologyPulling on the TCR
Nancy R. Gough
	Sci. Signal. 1 (9), ec79.  [DOI: 10.1126/stke.19ec79]
	In vitro experiments suggest that mechanical stress of the APC-T cell interaction is critical for T cell receptor activation.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;1/9/ec79?etoc

DevelopmentTranslating GAGs to Regulate Morphogens
Elizabeth M. Adler
	Sci. Signal. 1 (9), ec80.  [DOI: 10.1126/stke.19ec80]
	BMP signaling early in Drosophila embryogenesis escapes HSPG regulation because of a translational block of GAG synthesis.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;1/9/ec80?etoc

NeuroscienceTargeted Effects
John F. Foley
	Sci. Signal. 1 (9), ec81.  [DOI: 10.1126/stke.19ec81]
	Î²-catenin in muscle fibers, but not in motoneurons, is necessary for presynaptic neurotransmitter release in the neuromuscular junction.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;1/9/ec81?etoc

Protein StabilityPreventing Interaction with the Proteasome
Nancy R. Gough
	Sci. Signal. 1 (9), ec82.  [DOI: 10.1126/stke.19ec82]
	Phosphorylation of the coactivator SRC-3 by atypical protein kinase C blocks the interaction of SRC-3 with the proteasome.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;1/9/ec82?etoc

CalciumExtracellular Calcium Matters, Too
John F. Foley
	Sci. Signal. 1 (9), ec83.  [DOI: 10.1126/stke.19ec83]
	The extracellular calcium-sensing receptor (CaSR) is important for neurite outgrowth and branching.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;1/9/ec83?etoc

NeuroscienceMemory Breakdown
Peter R. Stern
	Sci. Signal. 1 (9), ec84.  [DOI: 10.1126/stke.19ec84]
	Upon recollection, mouse memories of fearful situations become labile, as postsynaptic proteins are degraded by proteasomes and are then reconsolidated via protein synthesis.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;1/9/ec84?etoc

NeuroscienceFruit Flies, Mosquitoes, and CO2 Sensations
Peter R. Stern
	Sci. Signal. 1 (9), ec85.  [DOI: 10.1126/stke.19ec85]
	Loss of a microRNA in Drosophila leads to misexpression of CO2-sensing neurons in the maxillary palps, an arrangement that is a hybrid between that of the fruit fly and the mosquito.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;1/9/ec85?etoc

Cell BiologyExplaining Polarized Growth Patterns
Stella M. Hurtley
	Sci. Signal. 1 (9), ec86.  [DOI: 10.1126/stke.19ec86]
	Accumulation of an oxidase enzyme at one end of Arabidopsis root hair cells generates reactive oxygen species, which in turn trigger calcium entry and directional growth.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;1/9/ec86?etoc

NeuroscienceDissecting Function in the Living Brain
Katrina L. Kelner
	Sci. Signal. 1 (9), ec87.  [DOI: 10.1126/stke.19ec87]
	Blockade of neural activity in the CA3 region of the hippocampus with a reversible, inducible transgenic method inhibits rapid learning but spares certain spatial tasks.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;1/9/ec87?etoc




Teaching Resources

EducationUsing Web-Based Discussion Forums as a Model of the Peer-Review Process and a Tool for Assessment
Sherry L. Jenkins, Ravi Iyengar, Maria A. Diverse-Pierluissi, Andrew M. Chan, Lakshmi A. Devi, Eric A. Sobie, Adrian T. Ting, and Daniel C. Weinstein
	Sci. Signal. 1 (9), tr2.  [DOI: 10.1126/stke.19tr2]
	Asynchronous discussion forums have several advantages over in-class journal club discussions.
http://stke.sciencemag.org/cgi/content/abstract/sigtrans;1/9/tr2?etoc



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