Welcome to Wilkes-Barre! Wilkes-Barre is a progressive city with industrial roots that resides in Northeastern Pennsylvania. The City is located on the Susquehanna River and is the seat of Luzerne County. Conveniently situated in the tri-state area, Wilkes-Barre offers easy access to highways and airports. Wilkes-Barre is only hours away from major cities like New York and Philadelphia.