Pikeville, Kentucky. Pikeville (/ËpaÉªkvÉl/) is a city in and the county seat of Pike County, Kentucky, United States.[3] During the 2010 U.S. Census, the population within Pikeville's city limits was 6,903. In Kentucky's current city classification system, Pikeville is a home rule-class city, a category that includes all of the state's more than 400 cities except for the two largest, Louisville and Lexington.