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Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.
Farrelly, L.A. and Thompson, R.E. and Zhao, S. and Lepack, A.E. and Lyu, Y. and Bhanu, N.V. and Zhang, B. and Loh, Y.H.E. and Ramakrishnan, A. and Vadodaria, K.C. and Heard, K.J. and Erikson, G. and Nakadai, T. and Bastle, R.M. and Lukasak, B.J. and Zebroski, H. and Alenina, N. and Bader, M. and Berton, O. and Roeder, R.G. and Molina, H. and Gage, F.H. and Shen, L. and Garcia, B.A. and Li, H. and Muir, T.W. and Maze, I.
Tissue curvature and apicobasal mechanical tension imbalance instruct cancer morphogenesis.
Messal, H.A. and Alt, S. and Ferreira, R.M.M. and Gribben, C. and Wang, V.M.Y. and Cotoi, C.G. and Salbreux, G. and Behrens, A.
Structure and function of the global topsoil microbiome.
Bahram, M. and Hildebrand, F. and Forslund, S.K. and Anderson, J.L. and Soudzilovskaia, N.A. and Bodegom, P.M. and Bengtsson-Palme, J. and Anslan, S. and Coelho, L.P. and Harend, H. and Huerta-Cepas, J. and Medema, M.H. and Maltz, M.R. and Mundra, S. and Olsson, P.A. and Pent, M. and Põlme, S. and Sunagawa, S. and Ryberg, M. and Tedersoo, L. and Bork, P.
Brochado, A.R. and Telzerow, A. and Bobonis, J. and Banzhaf, M. and Mateus, A. and Selkrig, J. and Huth, E. and Bassler, S. and Zamarreño Beas, J. and Zietek, M. and Ng, N. and Foerster, S. and Ezraty, B. and Py, B. and Barras, F. and Savitski, M.M. and Bork, P. and Göttig, S. and Typas, A.
Kinase-controlled phase transition of membraneless organelles in mitosis.
Rai, A.K. and Chen, J.X. and Selbach, M. and Pelkmans, L.
Maier, L. and Pruteanu, M. and Kuhn, M. and Zeller, G. and Telzerow, A. and Anderson, E.E. and Brochado, A.R. and Fernandez, K.C. and Dose, H. and Mori, H. and Patil, K.R. and Bork, P. and Typas, A.
Senescence-associated reprogramming promotes cancer stemness.
Milanovic, M. and Fan, D.N.Y. and Belenki, D. and Däbritz, J.H.M. and Zhao, Z. and Yu, Y. and Dörr, J.R. and Dimitrova, L. and Lenze, D. and Monteiro Barbosa, I.A. and Mendoza-Parra, M.A. and Kanashova, T. and Metzner, M. and Pardon, K. and Reimann, M. and Trumpp, A. and Dörken, B. and Zuber, J. and Gronemeyer, H. and Hummel, M. and Dittmar, G. and Lee, S. and Schmitt, C.A.
IL11 is a crucial determinant of cardiovascular fibrosis.
Schafer, S. and Viswanathan, S. and Widjaja, A.A. and Lim, W.W. and Moreno-Moral, A. and DeLaughter, D.M. and Ng, B. and Patone, G. and Chow, K. and Khin, E. and Tan, J. and Chothani, S.P. and Ye, L. and Rackham, O.J. and Ko, N.S. and Sahib, N.E. and Pua, C.J. and Zhen, N.T. and Xie, C. and Wang, M. and Maatz, H. and Lim, S. and Saar, K. and Blachut, S. and Petretto, E. and Schmidt, S. and Putoczki, T. and Guimarães-Camboa, N. and Wakimoto, H. and van Heesch, S. and Sigmundsson, K. and Lim, S.L. and Soon, J.L. and Chao, V.T. and Chua, Y.L. and Tan, T.E. and Evans, S.M. and Loh, Y.J. and Jamal, M.H. and Ong, K.K. and Chua, K.C. and Ong, B.H. and Chakaramakkil, M.J. and Seidman, J.G. and Seidman, C.E. and Hubner, N. and Sin, K.Y. and Cook, S.A.
Salt-responsive gut commensal modulates T(H)17 axis and disease.
Wilck, N. and Matus, M.G. and Kearney, S.M. and Olesen, S.W. and Forslund, K. and Bartolomaeus, H. and Haase, S. and Mähler, A. and Balogh, A. and Markó, L. and Vvedenskaya, O. and Kleiner, F.H. and Tsvetkov, D. and Klug, L. and Costea, P.I. and Sunagawa, S. and Maier, L. and Rakova, N. and Schatz, V. and Neubert, P. and Frätzer, C. and Krannich, A. and Gollasch, M. and Grohme, D.A. and Côrte-Real, B.F. and Gerlach, R.G. and Basic, M. and Typas, A. and Wu, C. and Titze, J.M. and Jantsch, J. and Boschmann, M. and Dechend, R. and Kleinewietfeld, M. and Kempa, S. and Bork, P. and Linker, R.A. and Alm, E.J. and Müller, D.N.
Single-molecule imaging reveals receptor-G protein interactions at cell surface hot spots.
Sungkaworn, T. and Jobin, M.L. and Burnecki, K. and Weron, A. and Lohse, M.J. and Calebiro, D.
Elling, U. and Wimmer, R.A. and Leibbrandt, A. and Burkard, T. and Michlits, G. and Leopoldi, A. and Micheler, T. and Abdeen, D. and Zhuk, S. and Aspalter, I.M. and Handl, C. and Liebergesell, J. and Hubmann, M. and Husa, A.M. and Kinzer, M. and Schuller, N. and Wetzel, E. and van de Loo, N. and Martinez, J.A.Z. and Estoppey, D. and Riedl, R. and Yang, F. and Fu, B. and Dechat, T. and Ivics, Z. and Agu, C.A. and Bell, O. and Blaas, D. and Gerhardt, H. and Hoepfner, D. and Stark, A. and Penninger, J.M.
Dekker, J. and Belmont, A.S. and Guttman, M. and Leshyk, V.O. and Lis, J.T. and Lomvardas, S. and Mirny, L.A. and O'Shea, C.C. and Park, P.J. and Ren, B. and Politz, J.C.R. and Shendure, J. and Zhong, S.
Public antibodies to malaria antigens generated by two LAIR1 insertion modalities.
Pieper, K. and Tan, J. and Piccoli, L. and Foglierini, M. and Barbieri, S. and Chen, Y. and Silacci-Fregni, C. and Wolf, T. and Jarrossay, D. and Anderle, M. and Abdi, A. and Ndungu, F.M. and Doumbo, O.K. and Traore, B. and Tran, T.M. and Jongo, S. and Zenklusen, I. and Crompton, P.D. and Daubenberger, C. and Bull, P.C. and Sallusto, F. and Lanzavecchia, A.
Polylox barcoding reveals haematopoietic stem cell fates realized in vivo.
Pei, W. and Feyerabend, T.B. and Rössler, J. and Wang, X. and Postrach, D. and Busch, K. and Rode, I. and Klapproth, K. and Dietlein, N. and Quedenau, C. and Chen, W. and Sauer, S. and Wolf, S. and Höfer, T. and Rodewald, H.Re.
Beagrie, R.A. and Pombo, A.
The B-cell receptor controls fitness of MYC-driven lymphoma cells via GSK3β inhibition.
Varano, G. and Raffel, S. and Sormani, M. and Zanardi, F. and Lonardi, S. and Zasada, C. and Perucho, L. and Petrocelli, V. and Haake, A. and Lee, A.K. and Bugatti, M. and Paul, U. and Van Anken, E. and Pasqualucci, L. and Rabadan, R. and Siebert, R. and Kempa, S. and Ponzoni, M. and Facchetti, F. and Rajewsky, K. and Casola, S.
Phylogenetic ctDNA analysis depicts early stage lung cancer evolution.
Abbosh, C. and Birkbak, N.J. and Wilson, G.A. and Jamal-Hanjani, M. and Constantin, T. and Salari, R. and Quesne, J.L. and Moore, D.A. and Veeriah, S. and Rosenthal, R. and Marafioti, T. and Kirkizlar, E. and Watkins, T.B.K. and McGranahan, N. and Ward, S. and Martinson, L. and Riley, J. and Fraioli, F. and Bakir, M.A. and Grönroos, E. and Zambrana, F. and Endozo, R. and Bi, W.L. and Fennessy, F.M. and Sponer, N. and Johnson, D. and Laycock, J. and Shafi, S. and Czyzewska-Khan, J. and Rowan, A. and Chambers, T. and Matthews, N. and Turajlic, S. and Hiley, C. and Lee, S.M. and Forster, M.D. and Ahmad, T. and Falzon, M. and Borg, E. and Lawrence, D. and Hayward, M. and Kolvekar, S. and Panagiotopoulos, N. and Janes, S.M. and Thakrar, R. and Ahmed, A. and Blackhall, F. and Summers, Y. and Hafez, D. and Naik, A. and Ganguly, A. and Kareht, S. and Shah, R. and Joseph, L. and Quinn, A.M. and Crosbie, P. and Naidu, B. and Middleton, G. and Langman, G. and Trotter, S. and Nicolson, M. and Remmen, H. and Kerr, K. and Chetty, M. and Gomersall, L. and Fennell, D.A. and Nakas, A. and Rathinam, S. and Anand, G. and Khan, S. and Russell, P. and Ezhil, V. and Ismail, B. and Irvin-Sellers, M. and Prakash, V. and Lester, J.F. and Kornaszewska, M. and Attanoos, R. and Adams, H. and Davies, H. and Oukrif, D. and Akarca, A.U. and Hartley, J.A. and Lowe, H.L. and Lock, S. and Iles, N. and Bell, H. and Ngai, Y. and Elgar, G. and Szallasi, Z. and Schwarz, R.F. and Herrero, J. and Stewart, A. and Quezada, S.A. and Van Loo, P. and Dive, C. and Lin, C.J. and Rabinowitz, M. and Aerts, H.J.W.L. and Hackshaw, A. and Shaw, J.A. and Zimmermann, B.G. and Swanton, C.
Tumour ischaemia by interferon-γ resembles physiological blood vessel regression.
Kammertoens, T. and Friese, C. and Arina, A. and Idel, C. and Briesemeister, D. and Rothe, M. and Ivanov, A. and Szymborska, A. and Patone, G. and Kunz, S. and Sommermeyer, D. and Engels, B. and Leisegang, M. and Textor, A. and Fehling, H.J. and Fruttiger, M. and Lohoff, M. and Herrmann, A. and Yu, H. and Weichselbaum, R. and Uckert, W. and Hübner, N. and Gerhardt, H. and Beule, D. and Schreiber, H. and Blankenstein, T.
Beagrie, R.A. and Scialdone, A. and Schueler, M. and Kraemer, D.C.A. and Chotalia, M. and Xie, S.Q. and Barbieri, M. and de Santiago, I. and Lavitas, L.M. and Branco, M.R. and Fraser, J. and Dostie, J. and Game, L. and Dillon, N. and Edwards, P.A.W. and Nicodemi, M. and Pombo, A.
Formation of new chromatin domains determines pathogenicity of genomic duplications.
Franke, M. and Ibrahim, D.M. and Andrey, G. and Schwarzer, W. and Heinrich, V. and Schoepflin, R. and Kraft, K. and Kempfer, R. and Jerkovic, I. and Chan, W.L. and Spielmann, M. and Timmermann, B. and Wittler, L. and Kurth, I. and Cambiaso, P. and Zuffardi, O. and Houge, G. and Lambie, L. and Brancati, F. and Pombo, A. and Vingron, M. and Spitz, F. and Mundlos, S.
Ecogenomics and potential biogeochemical impacts of globally abundant ocean viruses.
Roux, S. and Brum, J.R. and Dutilh, B.E. and Sunagawa, S. and Duhaime, M.B. and Loy, A. and Poulos, B.T. and Solonenko, N. and Lara, E. and Poulain, J. and Pesant, S. and Kandels-Lewis, S. and Dimier, C. and Picheral, M. and Searson, S. and Cruaud, C. and Alberti, A. and Duarte, C.M. and Gasol, J.M. and Vaque, D. and Bork, P. and Acinas, S.G. and Wincker, P. and Sullivan, M.B.
Pedersen, H.K. and Gudmundsdottir, V. and Nielsen, H.B. and Hyotylainen, T. and Nielsen, T. and Jensen, B.A.H. and Forslund, K. and Hildebrand, F. and Prifti, E. and Falony, G. and Le Chatelier, E. and Levenez, F. and Doré, J. and Mattila, I. and Plichta, D.R. and Pöhö, P. and Hellgren, L.I. and Arumugam, M. and Sunagawa, S. and Vieira-Silva, S. and Jørgensen, T. and Holm, J.B. and Trošt, K. and Kristiansen, K. and Brix, S. and Raes, J. and Wang, J. and Hansen, T. and Bork, P. and Brunak, S. and Oresic, M. and Ehrlich, S.D. and Pedersen, O.
Proteogenomics connects somatic mutations to signalling in breast cancer.
Mertins, P. and Mani, D.R. and Ruggles, K.V. and Gillette, M.A. and Clauser, K.R. and Wang, P. and Wang, X. and Qiao, J.W. and Cao, S. and Petralia, F. and Kawaler, E. and Mundt, F. and Krug, K. and Tu, Z. and Lei, J.T. and Gatza, M.L. and Wilkerson, M. and Perou, C.M. and Yellapantula, V. and Huang, K.L. and Lin, C. and McLellan, M.D. and Yan, P. and Davies, S.R. and Townsend, R.R. and Skates, S.J. and Wang, J. and Zhang, B. and Kinsinger, C.R. and Mesri, M. and Rodriguez, H. and Ding, L. and Paulovich, A.G. and Fenyoe, D. and Ellis, M.J. and Carr, S.A.
Plankton networks driving carbon export in the oligotrophic ocean.
Guidi, L. and Chaffron, S. and Bittner, L. and Eveillard, D. and Larhlimi, A. and Roux, S. and Darzi, Y. and Audic, S. and Berline, L. and Brum, J. and Coelho, L.P. and Espinoza, J.C.I. and Malviya, S. and Sunagawa, S. and Dimier, C. and Kandels-Lewis, S. and Picheral, M. and Poulain, J. and Searson, S. and Stemmann, L. and Not, F. and Hingamp, P. and Speich, S. and Follows, M. and Karp-Boss, L. and Boss, E. and Ogata, H. and Pesant, S. and Weissenbach, J. and Wincker, P. and Acinas, S.G. and Bork, P. and de Vargas, C. and Iudicone, D. and Sullivan, M.B. and Raes, J. and Karsenti, E. and Bowler, C. and Gorsky, G.
FOXO1 couples metabolic activity and growth state in the vascular endothelium.
Wilhelm, K. and Happel, K. and Eelen, G. and Schoors, S. and Oellerich, M.F. and Lim, R. and Zimmermann, B. and Aspalter, I.M. and Franco, C.A. and Boettger, T. and Braun, T. and Fruttiger, M. and Rajewsky, K. and Keller, C. and Brüning, J.C. and Gerhardt, H. and Carmeliet, P. and Potente, M.
A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens.
Tan, J. and Pieper, K. and Piccoli, L. and Abdi, A. and Foglierini, M. and Geiger, R. and Tully, C.M. and Jarrossay, D. and Ndungu, F.M. and Wambua, J. and Bejon, P. and Silacci Fregni, C. and Fernandez-Rodriguez, B. and Barbieri, S. and Bianchi, S. and Marsh, K. and Thathy, V. and Corti, D. and Sallusto, F. and Bull, P. and Lanzavecchia, A.
Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota.
Forslund, K. and Hildebrandt, F. and Nielsen, T. and Falony, G. and Le Chatelier, E. and Sunagawa, S. and Prifti, E. and Vieira-Silva, S. and Gudmundsdottir, V. and Pedersen, H.K. and Arumugam, M. and Kristiansen, K. and Voigt, A.Y. and Vestergaard, H. and Hercog, R. and Costea, P.I. and Kultima, J.R. and Li, J. and Jørgensen, T. and Levenez, F. and Dore, J. and Nielsen, H.B. and Brunak, S. and Raes, J. and Hansen, T. and Wang, J. and Ehrlich, S.D. and Bork, P. and Pedersen, O.
Crystal structure of the dynamin tetramer.
Reubold, T.F. and Faelber, K. and Plattner, N. and Posor, Y. and Ketel, K. and Curth, U. and Schlegel, J. and Anand, R. and Manstein, D.J. and Noé, F. and Haucke, V. and Daumke, O. and Eschenburg, S.
Genomic profiling of DNA methyltransferases reveals a role for DNMT3B in genic methylation.
Baubec, T. and Colombo, D.F. and Wirbelauer, C. and Schmidt, J. and Burger, L. and Krebs, A.R. and Akalin, A. and Schübeler, D.
Fatty acid carbon is essential for dNTP synthesis in endothelial cells.
Schoors, S. and Bruning, U. and Missiaen, R. and Queiroz, K.C.S. and Borgers, G. and Elia, I. and Zecchin, A. and Cantelmo, A.R. and Christen, S. and Goveia, J. and Heggermont, W. and Goddé, L. and Vinckier, S. and Van Veldhoven, P.P. and Eelen, G. and Schoonjans, L. and Gerhardt, H. and Dewerchin, M. and Baes, M. and De Bock, K. and Ghesquière, B. and Lunt, S.Y. and Fendt, S.M. and Carmeliet, P.
PLD3 in non-familial Alzheimer's disease.
Heilmann, S. and Drichel, D. and Clarimon, J. and Fernández, V. and Lacour, A. and Wagner, H. and Thelen, M. and Hernández, I. and Fortea, J. and Alegret, M. and Blesa, R. and Mauleón, A. and Roca, M.R. and Kornhuber, J. and Peters, O. and Heun, R. and Frölich, L. and Hüll, M. and Heneka, M.T. and Rüther, E. and Riedel-Heller, S. and Scherer, M. and Wiltfang, J. and Jessen, F. and Becker, T. and Tárraga, L. and Boada, M. and Maier, W. and Lleó, A. and Ruiz, A. and Nöthen, M.M. and Ramirez, A.
Primate-specific endogenous retrovirus-driven transcription defines naive-like stem cells.
Wang, J. and Xie, G. and Singh, M. and Ghanbarian, A.T. and Raskó, T. and Szvetnik, A. and Cai, H. and Besser, D. and Prigione, A. and Fuchs, N.V. and Schumann, G.G. and Chen, W. and Lorincz, M.C. and Ivics, Z. and Hurst, L.D. and Izsvák, Z.
Ranade, S.S. and Woo, S.H. and Dubin, A.E. and Moshourab, R.A. and Wetzel, C. and Petrus, M. and Mathur, J. and Bégay, V. and Coste, B. and Mainquist, J. and Wilson, A.J. and Francisco, A.G. and Reddy, K. and Qiu, Z. and Wood, J.N. and Lewin, G.R. and Patapoutian, A.
Gibbon genome and the fast karyotype evolution of small apes.
Carbone, L. and Harris, R.A. and Gnerre, S. and Veeramah, K.R. and Lorente-Galdos, B. and Huddleston, J. and Meyer, T.J. and Herrero, J. and Roos, C. and Aken, B. and Anaclerio, F. and Archidiacono, N. and Baker, C. and Barrell, D. and Batzer, M.A. and Beal, K. and Blancher, A. and Bohrson, C.L. and Brameier, M. and Campbell, M.S. and Capozzi, O. and Casola, C. and Chiatante, G. and Cree, A. and Damert, A. and de Jong, P.J. and Dumas, L. and Fernandez-Callejo, M. and Flicek, P. and Fuchs, N.V. and Gut, I. and Gut, M. and Hahn, M.W. and Hernandez-Rodriguez, J. and Hillier, L.W. and Hubley, R. and Ianc, B. and Izsvák, Z. and Jablonski, N.G. and Johnstone, L.M. and Karimpour-Fard, A. and Konkel, M.K. and Kostka, D. and Lazar, N.H. and Lee, S.L. and Lewis, L.R. and Liu, Y. and Locke, D.P. and Mallick, S. and Mendez, F.L. and Muffato, M. and Nazareth, L.V. and Nevonen, K.A. and O'Bleness, M. and Ochis, C. and Odom, D.T. and Pollard, K.S. and Quilez, J. and Reich, D. and Rocchi, M. and Schumann, G.G. and Searle, S. and Sikela, J.M. and Skollar, G. and Smit, A. and Sonmez, K. and ten Hallers, B. and Terhune, E. and Thomas, G.W.C. and Ullmer, B. and Ventura, M. and Walker, J.A. and Wall, J.D. and Walter, L. and Ward, M.C. and Wheelan, S.J. and Whelan, C.W. and White, S. and Wilhelm, L.J. and Woerner, A.E. and Yandell, M. and Zhu, B. and Hammer, M.F. and Marques-Bonet, T. and Eichler, E.E. and Fulton, L. and Fronick, C. and Muzny, D.M. and Warren, W.C. and Worley, K.C. and Rogers, J. and Wilson, R.K. and Gibbs, R.A.
Developmental biology: it takes muscle to make blood cells.
Sawamiphak, S. and Stainier, D.Y.R.
Two independent transcription initiation codes overlap on vertebrate core promoters.
Haberle, V. and Li, N. and Hadzhiev, Y. and Plessy, C. and Previti, C. and Nepal, C. and Gehrig, J. and Dong, X. and Akalin, A. and Suzuki, A.M. and van IJcken, W.F.J. and Armant, O. and Ferg, M. and Strähle, U. and Carninci, P. and Müller, F. and Lenhard, B.
Bone biology: vessels of rejuvenation.
Le Noble, F. and Le Noble, J.
Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.
Dörr, J.R. and Yu, Y. and Milanovic, M. and Beuster, G. and Zasada, C. and Däbritz, J.H.M. and Lisec, J. and Lenze, D. and Gerhardt, A. and Schleicher, K. and Kratzat, S. and Purfürst, B. and Walenta, S. and Mueller-Klieser, W. and Gräler, M. and Hummel, M. and Keller, U. and Buck, A.K. and Dörken, B. and Willmitzer, L. and Reimann, M. and Kempa, S. and Lee, S. and Schmitt, C.A.
M-CSF instructs myeloid lineage fate in single haematopoietic stem cells.
Mossadegh-Keller, N. and Sarrazin, S. and Kandalla, P.K. and Espinosa, L. and Stanley, E.R. and Nutt, S.L. and Moore, J. and Sieweke, M.H.
Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells.
Kleinewietfeld, M. and Manzel, A. and Titze, J. and Kvakan, H. and Yosef, N. and Linker, R.A. and Muller, D.N. and Hafler, D.A.
Circular RNAs are a large class of animal RNAs with regulatory potency.
Memczak, S. and Jens, M. and Elefsinioti, A. and Torti, F. and Krueger, J. and Rybak, A. and Maier, L. and Mackowiak, S.D. and Gregersen, L.H. and Munschauer, M. and Loewer, A. and Ziebold, U. and Landthaler, M. and Kocks, C. and le Noble, F. and Rajewsky, N.
Schloissnig, S. and Arumugam, M. and Sunagawa, S. and Mitreva, M. and Tap, J. and Zhu, A. and Waller, A. and Mende, D.R. and Kultima, J.R. and Martin, J. and Kota, K. and Sunyaev, S.R. and Weinstock, G.M. and Bork, P.
FMRP targets distinct mRNA sequence elements to regulate protein expression.
Ascano, M. and Mukherjee, N. and Bandaru, P. and Miller, J.B. and Nusbaum, J.D. and Corcoran, D.L. and Langlois, C. and Munschauer, M. and Dewell, S. and Hafner, M. and Williams, Z. and Ohler, U. and Tuschl, T.
Tissue engineering: Blood vessels on a chip.
Franco, C. and Gerhardt, H.
The clonal and mutational evolution spectrum of primary triple-negative breast cancers.
Shah, S.P. and Roth, A. and Goya, R. and Oloumi, A. and Ha, G. and Zhao, Y. and Turashvili, G. and Ding, J. and Tse, K. and Haffari, G. and Bashashati, A. and Prentice, L.M. and Khattra, J. and Burleigh, A. and Yap, D. and Bernard, V. and McPherson, A. and Shumansky, K. and Crisan, A. and Giuliany, R. and Heravi-Moussavi, A. and Rosner, J. and Lai, D. and Birol, I. and Varhol, R. and Tam, A. and Dhalla, N. and Zeng, T. and Ma, K. and Chan, S.K. and Griffith, M. and Moradian, A. and Cheng, S.W.G. and Morin, G.B. and Watson, P. and Gelmon, K. and Chia, S. and Chin, S.F. and Curtis, C. and Rueda, O.M. and Pharoah, P.D. and Damaraju, S. and Mackey, J. and Hoon, K. and Harkins, T. and Tadigotla, V. and Sigaroudinia, M. and Gascard, P. and Tlsty, T. and Costello, J.F. and Meyer, I.M. and Eaves, C.J. and Wasserman, W.W. and Jones, S. and Huntsman, D. and Hirst, M. and Caldas, C. and Marra, M.A. and Aparicio, S.
Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2.
Schmeisser, M.J. and Ey, E. and Wegener, S. and Bockmann, J. and Stempel, A.V. and Kuebler, A. and Janssen, A.L. and Udvardi, P.T. and Shiban, E. and Spilker, C. and Balschun, D. and Skryabin, B.V. and Dieck, S.t. and Smalla, K.H. and Montag, D. and Leblond, C.S. and Faure, P. and Torquet, N. and Le Sourd, A.M. and Toro, R. and Grabrucker, A.M. and Shoichet, S.A. and Schmitz, D. and Kreutz, M.R. and Bourgeron, T. and Gundelfinger, E.D. and Boeckers, T.M.
Deregulated MYC expression induces dependence upon AMPK-related kinase 5.
Liu, L. and Ulbrich, J. and Mueller, J. and Wuestefeld, T. and Aeberhard, L. and Kress, T.R. and Muthalagu, N. and Rycak, L. and Rudalska, R. and Moll, R. and Kempa, S. and Zender, L. and Eilers, M. and Murphy, D.J.
McDermott-Roe, C. and Ye, J. and Ahmed, R. and Sun, X.M. and Serafin, A. and Ware, J. and Bottolo, L. and Muckett, P. and Canas, X. and Zhang, J. and Rowe, G.C. and Buchan, R. and Lu, H. and Braithwaite, A. and Mancini, M. and Hauton, D. and Marti, R. and Garcia-Arumi, E. and Hubner, N. and Jacob, H. and Serikawa, T. and Zidek, V. and Papousek, F. and Kolar, F. and Cardona, M. and Ruiz-Meana, M. and Garcia-Dorado, D. and Comella, J.X. and Felkin, L.E. and Barton, P.J. and Arany, Z. and Pravenec, M. and Petretto, E. and Sanchis, D. and Cook, S.A.
Deep sequencing reveals 50 novel genes for recessive cognitive disorders.
Najmabadi, H. and Hu, H. and Garshasbi, M. and Zemojtel, T. and Abedini, S.S. and Chen, W. and Hosseini, M. and Behjati, F. and Haas, S. and Jamali, P. and Zecha, A. and Mohseni, M. and Puettmann, L. and Vahid, L.N. and Jensen, C. and Moheb, L.A. and Bienek, M. and Larti, F. and Mueller, I. and Weissmann, R. and Darvish, H. and Wrogemann, K. and Hadavi, V. and Lipkowitz, B. and Esmaeeli-Nieh, S. and Wieczorek, D. and Kariminejad, R. and Firouzabadi, S.G. and Cohen, M. and Fattahi, Z. and Rost, I. and Mojahedi, F. and Hertzberg, C. and Dehghan, A. and Rajab, A. and Banavandi, M.J.S. and Hoffer, J. and Falah, M. and Musante, L. and Kalscheuer, V. and Ullmann, R. and Kuss, A.W. and Tzschach, A. and Kahrizi, K. and Ropers, H.H.
Crystal structure of nucleotide-free dynamin.
Faelber, K. and Posor, Y. and Gao, S. and Held, M. and Roske, Y. and Schulze, D. and Haucke, V. and Noe, F. and Daumke, O.
Stem cells: Orphan receptors find a home.
Morin, R.D. and Mendez-Lago, M. and Mungall, A.J. and Goya, R. and Mungall, K.L. and Corbett, R.D. and Johnson, N.A. and Severson, T.M. and Chiu, R. and Field, M. and Jackman, S. and Krzywinski, M. and Scott, D.W. and Trinh, D.L. and Tamura-Wells, J. and Li, S. and Firme, M.R. and Rogic, S. and Griffith, M. and Chan, S. and Yakovenko, O. and Meyer, I.M. and Zhao, E.Y. and Smailus, D. and Moksa, M. and Chittaranjan, S. and Rimsza, L. and Brooks-Wilson, A. and Spinelli, J.J. and Ben-Neriah, S. and Meissner, B. and Woolcock, B. and Boyle, M. and McDonald, H. and Tam, A. and Zhao, Y. and Delaney, A. and Zeng, T. and Tse, K. and Butterfield, Y. and Birol, I. and Holt, R. and Schein, J. and Horsman, D.E. and Moore, R. and Jones, S.J.M. and Connors, J.M. and Hirst, M. and Gascoyne, R.D. and Marra, M.A.
Sawcer, S. and Hellenthal, G. and Pirinen, M. and Spencer, C.C. and Patsopoulos, N.A. and Moutsianas, L. and Dilthey, A. and Su, Z. and Freeman, C. and Hunt, S.E. and Edkins, S. and Gray, E. and Booth, D.R. and Potter, S.C. and Goris, A. and Band, G. and Oturai, A.B. and Strange, A. and Saarela, J. and Bellenguez, C. and Fontaine, B. and Gillman, M. and Hemmer, B. and Gwilliam, R. and Zipp, F. and Jayakumar, A. and Martin, R. and Leslie, S. and Hawkins, S. and Giannoulatou, E. and D'alfonso, S. and Blackburn, H. and Boneschi, F.M. and Liddle, J. and Harbo, H.F. and Perez, M.L. and Spurkland, A. and Waller, M.J. and Mycko, M.P. and Ricketts, M. and Comabella, M. and Hammond, N. and Kockum, I. and McCann, O.T. and Ban, M. and Whittaker, P. and Kemppinen, A. and Weston, P. and Hawkins, C. and Widaa, S. and Zajicek, J. and Dronov, S. and Robertson, N. and Bumpstead, S.J. and Barcellos, L.F. and Ravindrarajah, R. and Abraham, R. and Alfredsson, L. and Ardlie, K. and Aubin, C. and Baker, A. and Baker, K. and Baranzini, S.E. and Bergamaschi, L. and Bergamaschi, R. and Bernstein, A. and Berthele, A. and Boggild, M. and Bradfield, J.P. and Brassat, D. and Broadley, S.A. and Buck, D. and Butzkueven, H. and Capra, R. and Carroll, W.M. and Cavalla, P. and Celius, E.G. and Cepok, S. and Chiavacci, R. and Clerget-Darpoux, F. and Clysters, K. and Comi, G. and Cossburn, M. and Cournu-Rebeix, I. and Cox, M.B. and Cozen, W. and Cree, B.A. and Cross, A.H. and Cusi, D. and Daly, M.J. and Davis, E. and de Bakker, P.I. and Debouverie, M. and D'hooghe, M.B. and Dixon, K. and Dobosi, R. and Dubois, B. and Ellinghaus, D. and Elovaara, I. and Esposito, F. and Fontenille, C. and Foote, S. and Franke, A. and Galimberti, D. and Ghezzi, A. and Glessner, J. and Gomez, R. and Gout, O. and Graham, C. and Grant, S.F. and Guerini, F.R. and Hakonarson, H. and Hall, P. and Hamsten, A. and Hartung, H.P. and Heard, R.N. and Heath, S. and Hobart, J. and Hoshi, M. and Infante-Duarte, C. and Ingram, G. and Ingram, W. and Islam, T. and Jagodic, M. and Kabesch, M. and Kermode, A.G. and Kilpatrick, T.J. and Kim, C. and Klopp, N. and Koivisto, K. and Larsson, M. and Lathrop, M. and Lechner-Scott, J.S. and Leone, M.A. and Leppa, V. and Liljedahl, U. and Bomfim, I.L. and Lincoln, R.R. and Link, J. and Liu, J. and Lorentzen, A.R. and Lupoli, S. and Macciardi, F. and Mack, T. and Marriott, M. and Martinelli, V. and Mason, D. and McCauley, J.L. and Mentch, F. and Mero, I.L. and Mihalova, T. and Montalban, X. and Mottershead, J. and Myhr, K.M. and Naldi, P. and Ollier, W. and Page, A. and Palotie, A. and Pelletier, J. and Piccio, L. and Pickersgill, T. and Piehl, F. and Pobywajlo, S. and Quach, H.L. and Ramsay, P.P. and Reunanen, M. and Reynolds, R. and Rioux, J.D. and Rodegher, M. and Roesner, S. and Rubio, J.P. and Ruckert, I.M. and Salvetti, M. and Salvi, E. and Santaniello, A. and Schaefer, C.A. and Schreiber, S. and Schulze, C. and Scott, R.J. and Sellebjerg, F. and Selmaj, K.W. and Sexton, D. and Shen, L. and Simms-Acuna, B. and Skidmore, S. and Sleiman, P.M. and Smestad, C. and Sorensen, P.S. and Sondergaard, H.B. and Stankovich, J. and Strange, R.C. and Sulonen, A.M. and Sundqvist, E. and Syvanen, A.C. and Taddeo, F. and Taylor, B. and Blackwell, J.M. and Tienari, P. and Bramon, E. and Tourbah, A. and Brown, M.A. and Tronczynska, E. and Casas, J.P. and Tubridy, N. and Corvin, A. and Vickery, J. and Jankowski, J. and Villoslada, P. and Markus, H.S. and Wang, K. and Mathew, C.G. and Wason, J. and Palmer, C.N. and Wichmann, H.E. and Plomin, R. and Willoughby, E. and Rautanen, A. and Winkelmann, J. and Wittig, M. and Trembath, R.C. and Yaouanq, J. and Viswanathan, A.C. and Zhang, H. and Wood, N.W. and Zuvich, R. and Deloukas, P. and Langford, C. and Duncanson, A. and Oksenberg, J.R. and Pericak-Vance, M.A. and Haines, J.L. and Olsson, T. and Hillert, J. and Ivinson, A.J. and De Jager, P.L. and Peltonen, L. and Stewart, G.J. and Hafler, D.A. and Hauser, S.L. and McVean, G. and Donnelly, P. and Compston, A.
Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.
Stefater, J.A. and Lewkowich, I. and Rao, S. and Mariggi, G. and Carpenter, A.C. and Burr, A.R. and Fan, J. and Ajima, R. and Molkentin, J.D. and Williams, B.O. and Wills-Karp, M. and Pollard, J.W. and Yamaguchi, T. and Ferrara, N. and Gerhardt, H. and Lang, R.A.
Schwanhaeusser, B. and Busse, D. and Li, N. and Dittmar, G. and Schuchhardt, J. and Wolf, J. and Chen, W. and Selbach, M.
Arumugam, M. and Raes, J. and Pelletier, E. and Le Paslier, D. and Yamada, T. and Mende, D.R. and Fernandes, G.R. and Tap, J. and Bruls, T. and Batto, J.M. and Bertalan, M. and Borruel, N. and Casellas, F. and Fernandez, L. and Gautier, L. and Hansen, T. and Hattori, M. and Hayashi, T. and Kleerebezem, M. and Kurokawa, K. and Leclerc, M. and Levenez, F. and Manichanh, C. and Nielsen, H.B. and Nielsen, T. and Pons, N. and Poulain, J. and Qin, J. and Sicheritz-Ponten, T. and Tims, S. and Torrents, D. and Ugarte, E. and Zoetendal, E.G. and Wang, J. and Guarner, F. and Pedersen, O. and de Vos, W.M. and Brunak, S. and Dore, J. and Weissenbach, J. and Ehrlich, S.D. and Bork, P.
Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase.
Guarani, V. and Deflorian, G. and Franco, C.A. and Krüger, M. and Phng, L.K. and Bentley, K. and Toussaint, L. and Dequiedt, F. and Mostoslavsky, R. and Schmidt, M.H.H. and Zimmermann, B. and Brandes, R.P. and Mione, M. and Westphal, C.H. and Braun, T. and Zeiher, A.M. and Gerhardt, H. and Dimmeler, S. and Potente, M.
Gene expression divergence recapitulates the developmental hourglass model.
Kalinka, A.T. and Varga, K.M. and Gerrard, D.T. and Preibisch, S. and Corcoran, D.L. and Jarrells, J. and Ohler, U. and Bergman, C.M. and Tomancak, P.
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk.
Heinig, M. and Petretto, E. and Wallace, C. and Bottolo, L. and Rotival, M. and Lu, H. and Li, Y. and Sarwar, R. and Langley, S.R. and Bauerfeind, A. and Hummel, O. and Lee, Y.A. and Paskas, S. and Rintisch, C. and Saar, K. and Cooper, J. and Buchan, R. and Gray, E.E. and Cyster, J.G. and Braund, P. and Gracey, J. and Krishnan, U. and Moore, J.S. and Nelson, C.P. and Pollard, H. and Attwood, T. and Crisp-Hihn, A. and Foad, N. and Jolley, J. and Lloyd-Jones, H. and Muir, D. and Murray, E. and O'Leary, K. and Rankin, A. and Sambrook, J. and Godfroy, T. and Brocheton, J. and Proust, C. and Schmitz, G. and Heimerl, S. and Lugauer, I. and Belz, S. and Gulde, S. and Linsel-Nitschke, P. and Sager, H. and Schroeder, L. and Lundmark, P. and Syvannen, A.C. and Neudert, J. and Scholz, M. and Deloukas, P. and Gray, E. and Gwilliams, R. and Niblett, D. and Erdmann, J. and Hengstenberg, C. and Maouche, S. and Ouwehand, W.H. and Rice, C.M. and Samani, N.J. and Schunkert, H. and Goodall, A.H. and Schulz, H. and Roider, H.G. and Vingron, M. and Blankenberg, S. and Muenzel, T. and Zeller, T. and Szymczak, S. and Ziegler, A. and Tiret, L. and Smyth, D.J. and Pravenec, M. and Aitman, T.J. and Cambien, F. and Clayton, D. and Todd, J.A. and Huebner, N. and Cook, S.A.
Wnt11 patterns a myocardial electrical gradient through regulation of the L-type Ca(2+) channel.
Panakova, D. and Werdich, A.A. and Macrae, C.A.
Loss of fish actinotrichia proteins and the fin-to-limb transition.
Zhang, J. and Wagh, P. and Guay, D. and Sanchez-Pulido, L. and Padhi, B.K. and Korzh, V. and Andrade-Navarro, M.A. and Akimenko, M.A.
Developmental sensory experience balances cortical excitation and inhibition.
Dorrn, A.L. and Yuan, K. and Barker, A.J. and Schreiner, C.E. and Froemke, R.C.
Structural basis of oligomerization in the stalk region of dynamin-like MxA.
Gao, S. and von der Malsburg, A. and Paeschke, S. and Behlke, J. and Haller, O. and Kochs, G. and Daumke, O.
Ephrin-B2 regulates VEGFR2 function in developmental and tumour angiogenesis.
Sawamiphak, S. and Seidel, S. and Essmann, C.L. and Wilkinson, G.A. and Pitulescu, M.E. and Acker, T. and Acker-Palmer, A.
The genome of a songbird.
Warren, W.C. and Clayton, D.F. and Ellegren, H. and Arnold, A.P. and Hillier, L.W. and Kuenstner, A. and Searle, S. and White, S. and Vilella, A.J. and Fairley, S. and Heger, A. and Kong, L. and Ponting, C.P. and Jarvis, E.D. and Mello, C.V. and Minx, P. and Lovell, P. and Velho, T.A. and Ferris, M. and Balakrishnan, C.N. and Sinha, S. and Blatti, C. and London, S.E. and Li, Y. and Lin, Y.C. and George, J. and Sweedler, J. and Southey, B. and Gunaratne, P. and Watson, M. and Nam, K. and Backstroem, N. and Smeds, L. and Nabholz, B. and Itoh, Y. and Whitney, O. and Pfenning, A.R. and Howard, J. and Voelker, M. and Skinner, B.M. and Griffin, D.K. and Ye, L. and McLaren, W.M. and Flicek, P. and Quesada, V. and Velasco, G. and Lopez-Otin, C. and Puente, X.S. and Olender, T. and Lancet, D. and Smit, A.F. and Hubley, R. and Konkel, M.K. and Walker, J.A. and Batzer, M.A. and Gu, W. and Pollock, D.D. and Chen, L. and Cheng, Z. and Eichler, E.E. and Stapley, J. and Slate, J. and Ekblom, R. and Birkhead, T. and Burke, T. and Burt, D. and Scharff, C. and Adam, I. and Richard, H. and Sultan, M. and Soldatov, A. and Lehrach, H. and Edwards, S.V. and Yang, S.P. and Li, X. and Graves, T. and Fulton, L. and Nelson, J. and Chinwalla, A. and Hou, S. and Mardis, E.R. and Wilson, R.K.
Ancient animal microRNAs and the evolution of tissue identity.
Christodoulou, F. and Raible, F. and Tomer, R. and Simakov, O. and Trachana, K. and Klaus, S. and Snyman, H. and Hannon, G.J. and Bork, P. and Arendt, D.
Hanada, R. and Leibbrandt, A. and Hanada, T. and Kitaoka, S. and Furuyashiki, T. and Fujihara, H. and Trichereau, J. and Paolino, M. and Qadri, F. and Plehm, R. and Klaere, S. and Komnenovic, V. and Mimata, H. and Yoshimatsu, H. and Takahashi, N. and von Haeseler, A. and Bader, M. and Kilic, S.S. and Ueta, Y. and Pifl, C. and Narumiya, S. and Penninger, J.M.
Combinatorial binding predicts spatio-temporal cis-regulatory activity.
Zinzen, R.P. and Girardot, C. and Gagneur, J. and Braun, M. and Furlong, E.E.
CCR7 signalling as an essential regulator of CNS infiltration in T-cell leukaemia.
Buonamici, S. and Trimarchi, T. and Ruocco, M.G. and Reavie, L. and Cathelin, S. and Mar, B.G. and Klinakis, A. and Lukyanov, Y. and Tseng, J.C. and Sen, F. and Gehrie, E. and Li, M. and Newcomb, E. and Zavadil, J. and Meruelo, D. and Lipp, M. and Ibrahim, S. and Efstratiadis, A. and Zagzag, D. and Bromberg, J.S. and Dustin, M.L. and Aifantis, I.
Clustering of InsP3 receptors by InsP3 retunes their regulation by InsP3 and Ca2+.
Taufiq-Ur-Rahman, and Skupin, A. and Falcke, M. and Taylor, C.W.
The ubiquitylation machinery of the endoplasmic reticulum.
Hirsch, C. and Gauss, R. and Horn, S.C. and Neuber, O. and Sommer, T.
A viral microRNA functions as an orthologue of cellular miR-155.
Gottwein, E. and Mukherjee, N. and Sachse, C. and Frenzel, C. and Majoros, W.H. and Chi, J.T.A. and Braich, R. and Manoharan, M. and Soutschek, J. and Ohler, U. and Cullen, B.R.
Helicobacter exploits integrin for type IV secretion and kinase activation.
Kwok, T. and Zabler, D. and Urman, S. and Rohde, M. and Hartig, R. and Wessler, S. and Misselwitz, R. and Berger, J.M. and Sewald, N. and Koenig, W. and Backert, S.
Architectural and mechanistic insights into an EHD ATPase involved in membrane remodelling.
Daumke, O. and Lundmark, R. and Vallis, Y. and Martens, S. and Butler, P.J.G. and McMahon, H.T.
The menthol receptor TRPM8 is the principal detector of environmental cold.
Bautista, D.M. and Siemens, J. and Glazer, J.M. and Tsuruda, P.R. and Basbaum, A.I. and Stucky, C.L. and Jordt, S.E. and Julius, D.
Neuroscience: The brain's garbage men.
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis.
Hellström, M. and Phng, L.K. and Hofmann, J.J. and Wallgard, E. and Coultas, L. and Lindblom, P. and Alva, J. and Nilsson, A.K. and Karlsson, L. and Gaiano, N. and Yoon, K. and Rossant, J. and Iruela-Arispe, M.L. and Kalén, M. and Gerhardt, H. and Betsholtz, C.
A stomatin-domain protein essential for touch sensation in the mouse.
Wetzel, C. and Hu, J. and Riethmacher, D. and Benckendorff, A. and Harder, L. and Eilers, A. and Moshourab, R. and Kozlenkov, A. and Labuz, D. and Caspani, O. and Erdmann, B. and Machelska, H. and Heppenstall, P.A. and Lewin, G.R.
Spider toxins activate the capsaicin receptor to produce inflammatory pain.
Siemens, J.E. and Zhou, S. and Piskorowski, R. and Nikai, T. and Lumpkin, E.A. and Basbaum, A.I. and King, D. and Julius, D.
Insights into social insects from the genome of the honeybee Apis mellifera.
Co-evolution of transcriptional and post-translational cell-cycle regulation.
Jensen, L.J. and Jensen, T.S. and de Lichtenberg, U. and Brunak, S. and Bork, P.
Hungary's 'reforms' are threatening basic science.
Izsvak, Z. and Ivics, Z. and Mates, L.
Proteome survey reveals modularity of the yeast cell machinery.
Gavin, A.C. and Aloy, P. and Grandi, P. and Krause, R. and Boesche, M. and Marzioch, M. and Rau, C. and Jensen, L.J. and Bastuck, S. and Duempelfeld, B. and Edelmann, A. and Heurtier, M.A. and Hoffman, V. and Hoefert, C. and Klein, K. and Hudak, M. and Michon, A.M. and Schelder, M. and Schirle, M. and Remor, M. and Rudi, T. and Hooper, S. and Bauer, A. and Bouwmeester, T. and Casari, G. and Drewes, G. and Neubauer, G. and Rick, J.M. and Kuster, B. and Bork, P. and Russell, R.B. and Superti-Furga, G.
Robust Salmonella metabolism limits possibilities for new antimicrobials.
Becker, D. and Selbach, M. and Rollenhagen, C. and Ballmaier, M. and Meyer, T.F. and Mann, M. and Bumann, D.
ClC-7 requires Ostm1 as a beta-subunit to support bone resorption and lysosomal function.
Lange, P.F. and Wartosch, L. and Jentsch, T.J. and Fuhrmann, J.C.
Silencing of microRNAs in vivo with 'antagomirs'.
Krutzfeldt, J. and Rajewsky, N. and Braich, R. and Rajeev, K.G. and Tuschl, T. and Manoharan, M. and Stoffel, M.
Initial sequence of the chimpanzee genome and comparison with the human genome.
Mikkelsen, T.S. and Hillier, L.W. and Eichler, E.E. and Zody, M.C. and Jaffe, D.B. and Yang, S.P. and Enard, W. and Hellmann, I. and Lindblad-Toh, K. and Altheide, T.K. and Archidiacono, N. and Bork, P. and Butler, J. and Chang, J.L. and Cheng, Z. and Chinwalla, A.T. and de Jong, P. and Delehaunty, K.D. and Fronick, C.C. and Fulton, L.L. and Gilad, Y. and Glusman, G. and Gnerre, S. and Graves, T.A. and Hayakawa, T. and Hayden, K.E. and Huang, X.Q. and Ji, H.K. and Kent, W.J. and King, M.C. and Kulbokas, E.J. and Lee, M.K. and Liu, G. and Lopez-Otin, C. and Makova, K.D. and Man, O. and Mardis, E.R. and Mauceli, E. and Miner, T.L. and Nash, W.E. and Nelson, J.O. and Paeaebo, S. and Patterson, N.J. and Pohl, C.S. and Pollard, K.S. and Pruefer, K. and Puente, X.S. and Reich, D. and Rocchi, M. and Rosenbloom, K. and Ruvolo, M. and Richter, D.J. and Schaffner, S.F. and Smit, A.F.A. and Smith, S.M. and Suyama, M. and Taylor, J. and Torrents, D. and Tuzun, E. and Varki, A. and Velasco, G. and Ventura, M. and Wallis, J.W. and Wendl, M.C. and Wilson, R.K. and Lander, E.S. and Waterston, R.H.
Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance.
Willimsky, G. and Blankenstein, T.
Oncogene-induced senescence as an initial barrier in lymphoma development.
Braig, M. and Lee, S. and Loddenkemper, C. and Rudolph, C. and Peters, A.H. and Schlegelberger, B. and Stein, H. and Doerken, B. and Jenuwein, T. and Schmitt, C.A.
Voltage-dependent electrogenic chloride/proton exchange by endosomal CLC proteins.
Scheel, O. and Zdebik, A.A. and Lourdel, S. and Jentsch, T.J.
Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
Hillier, L.W. and Graves, T.A. and Fulton, R.S. and Fulton, L.A. and Pepin, K.H. and Minx, P. and Wagner-McPherson, C. and Layman, D. and Wylie, K. and Sekhon, M. and Becker, M.C. and Fewell, G.A. and Delehaunty, K.D. and Miner, T.L. and Nash, W.E. and Kremitzki, C. and Oddy, L. and Du, H. and Sun, H. and Bradshaw-Cordum, H. and Ali, J. and Carter, J. and Cordes, M. and Harris, A. and Isak, A. and van Brunt, A. and Nguyen, C. and Du, F. and Courtney, L. and Kalicki, J. and Ozersky, P. and Abbott, S. and Armstrong, J. and Belter, E.A. and Caruso, L. and Cedroni, M. and Cotton, M. and Davidson, T. and Desai, A. and Elliott, G. and Erb, T. and Fronick, C. and Gaige, T. and Haakenson, W. and Haglund, K. and Holmes, A. and Harkins, R. and Kim, K. and Kruchowski, S.S. and Strong, C.M. and Grewal, N. and Goyea, E. and Hou, S. and Levy, A. and Martinka, S. and Mead, K. and McLellan, M.D. and Meyer, R. and Randall-Maher, J. and Tomlinson, C. and uphin-Kohlberg, S. and Kozlowicz-Reilly, A. and Shah, N. and Swearengen-Shahid, S. and Snider, J. and Strong, J.T. and Thompson, J. and Yoakum, M. and Leonard, S. and Pearman, C. and Trani, L. and Radionenko, M. and Waligorski, J.E. and Wang, C. and Rock, S.M. and Tin-Wollam, A.M. and Maupin, R. and Latreille, P. and Wendl, M.C. and Yang, S.P. and Pohl, C. and Wallis, J.W. and Spieth, J. and Bieri, T.A. and Berkowicz, N. and Nelson, J.O. and Osborne, J. and Ding, L. and Meyer, R. and Sabo, A. and Shotland, Y. and Sinha, P. and Wohldmann, P.E. and Cook, L.L. and Hickenbotham, M.T. and Eldred, J. and Williams, D. and Jones, T.A. and She, X. and Ciccarelli, F.D. and Izaurralde, E. and Taylor, J. and Schmutz, J. and Myers, R.M. and Cox, D.R. and Huang, X. and McPherson, J.D. and Mardis, E.R. and Clifton, S.W. and Warren, W.C. and Chinwalla, A.T. and Eddy, S.R. and Marra, M.A. and Ovcharenko, I. and Furey, T.S. and Miller, W. and Eichler, E.E. and Bork, P. and Suyama, M. and Torrents, D. and Waterston, R.H. and Wilson, R.K.
Hillier, L.W. and Miller, W. and Birney, E. and Warren, W. and Hardison, R.C. and Ponting, C.P. and Bork, P. and Burt, D.W. and Groenen, M.A.M. and Delany, M.E. and Dodgson, J.B. and Chinwalla, A.T. and Cliften, P.F. and Clifton, S.W. and Delehaunty, K.D. and Fronick, C. and Fulton, R.S. and Graves, T.A. and Kremitzki, C. and Layman, D. and Magrini, V. and McPherson, J.D. and Miner, T.L. and Minx, P. and Nash, W.E. and Nhan, M.N. and Nelson, J.O. and Oddy, L.G. and Pohl, C.S. and Randall-Maher, J. and Smith, S.M. and Wallis, J.W. and Yang, S.P. and Romanov, M.N. and Rondelli, C.M. and Paton, B. and Smith, J. and Morrice, D. and Daniels, L. and Tempest, H.G. and Robertson, L. and Masabanda, J.S. and Griffin, D.K. and Vignal, A. and Fillon, V. and Jacobbson, L. and Kerje, S. and Andersson, L. and Crooijmans, R.P.M. and Aerts, J. and van der Poel, J.J. and Ellegren, H. and Caldwell, R.B. and Hubbard, S.J. and Grafham, D.V. and Kierzek, A.M. and McLaren, S.R. and Overton, I.M. and Arakawa, H. and Beattie, K.J. and Bezzubov, Y. and Boardman, P.E. and Bonfield, J.K. and Croning, M.D.R. and Davies, R.M. and Francis, M.D. and Humphray, S.J. and Scott, C.E. and Taylor, R.G. and Tickle, C. and Brown, W.R.A. and Rogers, J. and Buerstedde, J.M. and Wilson, S.A. and Stubbs, L. and Ovcharenko, I. and Gordon, L. and Lucas, S. and Miller, M.M. and Inoko, H. and Shiina, T. and Kaufman, J. and Salomonsen, J. and Skjoedt, K. and Wong, G.K.S. and Wang, J. and Liu, B. and Wang, J. and Yu, J. and Yang, H.M. and Nefedov, M. and Koriabine, M. and de Jong, P.J. and Goodstadt, L. and Webber, C. and Dickens, N.J. and Letunic, I. and Suyama, M. and Torrents, D. and von Mering, C. and Zdobnov, E.M. and Makova, K. and Nekrutenko, A. and Elnitski, L. and Eswara, P. and King, D.C. and Yang, S. and Tyekucheva, S. and Radakrishnan, A. and Harris, R.S. and Chiaromonte, F. and Taylor, J. and He, J.B. and Rijnkels, M. and Griffiths-Jones, S. and Ureta-Vidal, A. and Hoffman, M.M. and Severin, J. and Searle, S.M.J. and Law, A.S. and Speed, D. and Waddington, D. and Cheng, Z. and Tuzun, E. and Eichler, E. and Bao, Z.R. and Flicek, P. and Shteynberg, D.D. and Brent, M.R. and Bye, J.M. and Huckle, E.J. and Chatterji, S. and Dewey, C. and Pachter, L. and Kouranov, A. and Mourelatos, Z. and Hatzigeorgiou, A.G. and Paterson, A.H. and Ivarie, R. and Brandstrom, M. and Axelsson, E. and Backstrom, N. and Berlin, S. and Webster, M.T. and Pourquie, O. and Reymond, A. and Ucla, C. and Antonarakis, S.E. and Long, M.Y. and Emerson, J.J. and Betran, E. and Dupanloup, I. and Kaessmann, H. and Hinrichs, A.S. and Bejerano, G. and Furey, T.S. and Harte, R.A. and Raney, B. and Siepel, A. and Kent, W.J. and Haussler, D. and Eyras, E. and Castelo, R. and Abril, J.F. and Castellano, S. and Camara, F. and Parra, G. and Guigo, R. and Bourque, G. and Tesler, G. and Pevzner, P.A. and Smit, A. and Fulton, L.A. and Mardis, E.R. and Wilson, R.K.
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system.
Lu, X. and Le Noble, F. and Yuan, L. and Jiang, Q. and De Lafarge, B. and Sugiyama, D. and Breant, C. and Claes, F. and De Smet, F. and Thomas, J.L. and Autiero, M. and Carmeliet, P. and Tessier-Lavigne, M. and Eichmann, A.
A pancreatic islet-specific microRNA regulates insulin secretion.
Poy, M.N. and Eliasson, L. and Krutzfeldt, J. and Kuwajima, S. and Ma, X. and Macdonald, P.E. and Pfeffer, S. and Tuschl, T. and Rajewsky, N. and Rorsman, P. and Stoffel, M.
Complex auditory behaviour emerges from simple reactive steering.
Hedwig, B. and Poulet, J.F.A.
Cadherin 23 is a component of the tip link in hair-cell stereocilia.
Siemens, J. and Lillo, C. and Dumont, R.A. and Reynolds, A. and Williams, D.S. and Gillespie, P.G. and Mueller, U.
Mutations in cadherin 23 affect tip links in zebrafish sensory hair cells.
Soellner, C. and Rauch, G.J. and Siemens, J. and Geisler, R. and Schuster, S.C. and Mueller, U. and Nicolson, T.
Genome sequence of the Brown Norway rat yields insights into mammalian evolution.
Gibbs, R.A. and Weinstock, G.M. and Metzker, M.L. and Muzny, D.M. and Sodergren, E.J. and Scherer, S. and Scott, G. and Steffen, D. and Worley, K.C. and Burch, P.E. and Okwuonu, G. and Hines, S. and Lewis, L. and DeRamo, C. and Delgado, O. and Dugan-Rocha, S. and Miner, G. and Morgan, M. and Hawes, A. and Gill, R. and Holt, R.A. and Adams, M.D. and Amanatides, P.G. and Baden-Tillson, H. and Barnstead, M. and Chin, S. and Evans, C.A. and Ferriera, S. and Fosler, C. and Glodek, A. and Gu, Z. and Jennings, D. and Kraft, C.L. and Nguyen, T. and Pfannkoch, C.M. and Sitter, C. and Sutton, G.G. and Venter, J.C. and Woodage, T. and Smith, D. and Lee, H.M. and Gustafson, E. and Cahill, P. and Kana, A. and Doucette-Stamm, L. and Weinstock, K. and Fechtel, K. and Weiss, R.B. and Dunn, D.M. and Green, E.D. and Blakesley, R.W. and Bouffard, G.G. and de Jong, P.J. and Osoegawa, K. and Zhu, B. and Marra, M. and Schein, J. and Bosdet, I. and Fjell, C. and Jones, S. and Krzywinski, M. and Mathewson, C. and Siddiqui, A. and Wye, N. and McPherson, J. and Zhao, S. and Fraser, C.M. and Shetty, J. and Shatsman, S. and Geer, K. and Chen, Y. and Abramzon, S. and Nierman, W.C. and Havlak, P.H. and Chen, R. and Durbin, K.J. and Egan, A. and Ren, Y. and Song, X.Z. and Li, B. and Liu, Y. and Qin, X. and Cawley, S. and Worley, K.C. and Cooney, A.J. and D'Souza, L.M. and Martin, K. and Wu, J.Q. and Gonzalez-Garay, M.L. and Jackson, A.R. and Kalafus, K.J. and McLeod, M.P. and Milosavljevic, A. and Virk, D. and Volkov, A. and Wheeler, D.A. and Zhang, Z. and Bailey, J.A. and Eichler, E.E. and Tuzun, E. and Birney, E. and Mongin, E. and Ureta-Vidal, A. and Woodwark, C. and Zdobnov, E. and Bork, P. and Suyama, M. and Torrents, D. and Alexandersson, M. and Trask, B.J. and Young, J.M. and Huang, H. and Wang, H. and Xing, H. and Daniels, S. and Gietzen, D. and Schmidt, J. and Stevens, K. and Vitt, U. and Wingrove, J. and Camara, F. and Alba, M.M. and Abril, J.F. and Guigo, R. and Smit, A. and Dubchak, I. and Rubin, E.M. and Couronne, O. and Poliakov, A. and Huebner, N. and Ganten, D. and Goesele, C. and Hummel, O. and Kreitler, T. and Lee, Y.A. and Monti, J. and Schulz, H. and Zimdahl, H. and Himmelbauer, H. and Lehrach, H. and Jacob, H.J. and Bromberg, S. and Gullings-Handley, J. and Jensen-Seaman, M.I. and Kwitek, A.E. and Lazar, J. and Pasko, D. and Tonellato, P.J. and Twigger, S. and Ponting, C.P. and Duarte, J.M. and Rice, S. and Goodstadt, L. and Beatson, S.A. and Emes, R.D. and Winter, E.E. and Webber, C. and Brandt, P. and Nyakatura, G. and Adetobi, M. and Chiaromonte, F. and Elnitski, L. and Eswara, P. and Hardison, R.C. and Hou, M. and Kolbe, D. and Makova, K. and Miller, W. and Nekrutenko, A. and Riemer, C. and Schwartz, S. and Taylor, J. and Yang, S. and Zhang, Y. and Lindpaintner, K. and Andrews, T.D. and Caccamo, M. and Clamp, M. and Clarke, L. and Curwen, V. and Durbin, R. and Eyras, E. and Searle, S.M. and Cooper, G.M. and Batzoglou, S. and Brudno, M. and Sidow, A. and Stone, E.A. and Venter, J.C. and Payseur, B.A. and Bourque, G. and Lopez-Otin, C. and Puente, X.S. and Chakrabarti, K. and Chatterji, S. and Dewey, C. and Pachter, L. and Bray, N. and Yap, V.B. and Caspi, A. and Tesler, G. and Pevzner, P.A. and Haussler, D. and Roskin, K.M. and Baertsch, R. and Clawson, H. and Furey, T.S. and Hinrichs, A.S. and Karolchik, D. and Kent, W.J. and Rosenbloom, K.R. and Trumbower, H. and Weirauch, M. and Cooper, D.N. and Stenson, P.D. and Ma, B. and Brent, M. and Arumugam, M. and Shteynberg, D. and Copley, R.R. and Taylor, M.S. and Riethman, H. and Mudunuri, U. and Peterson, J. and Guyer, M. and Felsenfeld, A. and Old, S. and Mockrin, S. and Collins, F.
Sortilin is essential for proNGF-induced neuronal cell death.
Nykjaer, A. and Lee, R. and Teng, K.K. and Jansen, P. and Madsen, P. and Nielsen, M.S. and Jacobsen, C. and Kliemannel, M. and Schwarz, E. and Willnow, T.E. and Hempstead, B.L. and Petersen, C.M.
Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion.
Prinz, M. and Heikenwalder, M. and Junt, T. and Schwarz, P. and Glatzel, M. and Heppner, F.L. and Fu, Y.X. and Lipp, M. and Aguzzi, A.
The DNA sequence of human chromosome 7.
Hillier, L.W. and Fulton, R.S. and Fulton, L.A. and Graves, T.A. and Pepin, K.H. and Wagner-McPherson, C. and Layman, D. and Maas, J. and Jaeger, S. and Walker, R. and Wylie, K. and Sekhon, M. and Becker, M.C. and O'Laughlin, M.D. and Schaller, M.E. and Fewell, G.A. and Delehaunty, K.D. and Miner, T.L. and Nash, W.E. and Cordes, M. and Du, H. and Sun, H. and Edwards, J. and Bradshaw-Cordum, H. and Ali, J. and Andrews, S. and Isak, A. and VanBrunt, A. and Nguyen, C. and Du, F.Y. and Lamar, B. and Courtney, L. and Kalicki, J. and Ozersky, P. and Bielicki, L. and Scott, K. and Holmes, A. and Harkins, R. and Harris, A. and Strong, C.M. and Hou, S.F. and Tomlinson, C. and Dauphin-Kohlberg, S. and Kozlowicz-Reilly, A. and Leonard, S. and Rohlfing, T. and Rock, S.M. and Tin-Wollam, A.M. and Abbott, A. and Minx, P. and Maupin, R. and Strowmatt, C. and Latreille, P. and Miller, N. and Johnson, D. and Murray, J. and Woessner, J.P. and Wendl, M.C. and Yang, S.P. and Schultz, B.R. and Wallis, J.W. and Spieth, J. and Bieri, T.A. and Nelson, J.O. and Berkowicz, N. and Wohldmann, P.E. and Cook, L.L. and Hickenbotham, M.T. and Eldred, J. and Williams, D. and Bedell, J.A. and Mardis, E.R. and Clifton, S.W. and Chissoe, S.L. and Marra, M.A. and Raymond, C. and Haugen, E. and Gillett, W. and Zhou, Y. and James, R. and Phelps, K. and Iadanoto, S. and Bubb, K. and Simms, E. and Levy, R. and Clendenning, J. and Kaul, R. and Kent, W.J. and Furey, T.S. and Baertsch, R.A. and Brent, M.R. and Keibler, E. and Flicek, P. and Bork, P. and Suyama, M. and Bailey, J.A. and Portnoy, M.E. and Torrents, D. and Chinwalla, A.T. and Gish, W.R. and Eddy, S.R. and McPherson, J.D. and Olson, M.V. and Eichler, E.E. and Green, E.D. and Waterston, R.H. and Wilson, R.K.
Initial sequencing and comparative analysis of the mouse genome.
Waterston, R.H. and Lindblad-Toh, K. and Birney, E. and Rogers, J. and Abril, J.F. and Agarwal, P. and Agarwala, R. and Ainscough, R. and Alexandersson, M. and An, P. and Antonarakis, S.E. and Attwood, J. and Baertsch, R. and Bailey, J. and Barlow, K. and Beck, S. and Berry, E. and Birren, B. and Bloom, T. and Bork, P. and Botcherby, M. and Bray, N. and Brent, M.R. and Brown, D.G. and Brown, S.D. and Bult, C. and Burton, J. and Butler, J. and Campbell, R.D. and Carninci, P. and Cawley, S. and Chiaromonte, F. and Chinwalla, A.T. and Church, D.M. and Clamp, M. and Clee, C. and Collins, F.S. and Cook, L.L. and Copley, R.R. and Coulson, A. and Couronne, O. and Cuff, J. and Curwen, V. and Cutts, T. and Daly, M. and David, R. and Davies, J. and Delehaunty, K.D. and Deri, J. and Dermitzakis, E.T. and Dewey, C. and Dickens, N.J. and Diekhans, M. and Dodge, S. and Dubchak, I. and Dunn, D.M. and Eddy, S.R. and Elnitski, L. and Emes, R.D. and Eswara, P. and Eyras, E. and Felsenfeld, A. and Fewell, G.A. and Flicek, P. and Foley, K. and Frankel, W.N. and Fulton, L.A. and Fulton, R.S. and Furey, T.S. and Gage, D. and Gibbs, R.A. and Glusman, G. and Gnerre, S. and Goldman, N. and Goodstadt, L. and Grafham, D. and Graves, T.A. and Green, E.D. and Gregory, S. and Guigo, R. and Guyer, M. and Hardison, R.C. and Haussler, D. and Hayashizaki, Y. and Hillier, L.W. and Hinrichs, A. and Hlavina, W. and Holzer, T. and Hsu, F. and Hua, A. and Hubbard, T. and Hunt, A. and Jackson, I. and Jaffe, D.B. and Johnson, L.S. and Jones, M. and Jones, T.A. and Joy, A. and Kamal, M. and Karlsson, E.K. and Karolchik, D. and Kasprzyk, A. and Kawai, J. and Keibler, E. and Kells, C. and Kent, W.J. and Kirby, A. and Kolbe, D.L. and Korf, I. and Kucherlapati, R.S. and Kulbokas, E.J. and Kulp, D. and Landers, T. and Leger, J.P. and Leonard, S. and Letunic, I. and LeVine, R. and Li, J. and Li, M. and Lloyd, C. and Lucas, S. and Ma, B. and Maglott, D.R. and Mardis, E.R. and Matthews, L. and Mauceli, E. and Mayer, J.H. and McCarthy, M. and McCombie, W.R. and McLaren, S. and McLay, K. and McPherson, J.D. and Meldrim, J. and Meredith, B. and Mesirov, J.P. and Miller, W. and Miner, T.L. and Mongin, E. and Montgomery, K.T. and Morgan, M. and Mott, R. and Mullikin, J.C. and Muzny, D.M. and Nash, W.E. and Nelson, J.O. and Nhan, M.N. and Nicol, R. and Ning, Z. and Nusbaum, C. and O'Connor, M.J. and Okazaki, Y. and Oliver, K. and Overton-Larty, E. and Pachter, L. and Parra, G. and Pepin, K.H. and Peterson, J. and Pevzner, P. and Plumb, R. and Pohl, C.S. and Poliakov, A. and Ponce, T.C. and Ponting, C.P. and Potter, S. and Quail, M. and Reymond, A. and Roe, B.A. and Roskin, K.M. and Rubin, E.M. and Rust, A.G. and Santos, R. and Sapojnikov, V. and Schultz, B. and Schultz, J. and Schwartz, M.S. and Schwartz, S. and Scott, C. and Seaman, S. and Searle, S. and Sharpe, T. and Sheridan, A. and Shownkeen, R. and Sims, S. and Singer, J.B. and Slater, G. and Smit, A. and Smith, D.R. and Spencer, B. and Stabenau, A. and Stange-Thomann, N. and Sugnet, C. and Suyama, M. and Tesler, G. and Thompson, J. and Torrents, D. and Trevaskis, E. and Tromp, J. and Ucla, C. and Ureta-Vidal, A. and Vinson, J.P. and von Niederhausern, A.C. and Wade, C.M. and Wall, M. and Weber, R.J. and Weiss, R.B. and Wendl, M.C. and West, A.P. and Wetterstrand, K. and Wheeler, R. and Whelan, S. and Wierzbowski, J. and Willey, D. and Williams, S. and Wilson, R.K. and Winter, E. and Worley, K.C. and Wyman, D. and Yang, S. and Yang, S.P. and Zdobnov, E.M. and Zody, M.C. and Lander, E.S.
Metabolic network structure determines key aspects of functionality and regulation.
Stelling, J. and Klamt, S. and Bettenbrock, K. and Schuster, S. and Gilles, E.D.
A corollary discharge maintains auditory sensitivity during sound production.
Poulet, J.F.A. and Hedwig, B.
Genome organization: Teamed up for transcription.
von Mering, C. and Bork, P.
Comparative assessment of large-scale data sets of protein-protein interactions.
von Mering, C. and Krause, R. and Snel, B. and Cornell, M. and Oliver, S.G. and Fields, S. and Bork, P.
Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4.
Boettger, T. and Huebner, C.A. and Maier, H. and Rust, M.B. and Beck, F.X. and Jentsch, T.J.
Functional organization of the yeast proteome by systematic analysis of protein complexes.
Gavin, A.C. and Boesche, M. and Krause, R. and Grandi, P. and Marzioch, M. and Bauer, A. and Schultz, J. and Rick, J.M. and Michon, A.M. and Cruciat, C.M. and Remor, M. and Hoefert, C. and Schelder, M. and Brajenovic, M. and Ruffner, H. and Merino, A. and Klein, K. and Hudak, M. and Dickson, D. and Rudi, T. and Gnau, V. and Bauch, A. and Bastuck, S. and Huhse, B. and Leutwein, C. and Heurtier, M.A. and Copley, R.R. and Edelmann, A. and Querfurth, E. and Rybin, V. and Drewes, G. and Raida, M. and Bouwmeester, T. and Bork, P. and Seraphin, B. and Kuester, B. and Neubauer, G. and Superti-Furga, G.
Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position.
Reif, K. and Ekland, E.H. and Ohl, L. and Nakano, H. and Lipp, M. and Foerster, R. and Cyster, J.G.
Barttin is a Cl- channel beta-subunit crucial for renal Cl- reabsorption and inner ear K+ secretion.
Estevez, R. and Boettger, T. and Stein, V. and Birkenhaeger, R. and Otto, E. and Hildebrandt, F. and Jentsch, T.J.
Planned law could put German research at risk.
Hero or villain? Stasi archives shed light on russian scientist.
Hossfeld, U. and Walker, M.
Skewed maturation of memory HIV-specific CD8 T lymphocytes.
Champagne, P. and Ogg, G.S. and King, A.S. and Knabenhans, C. and Ellefsen, K. and Nobile, M. and Appay, V. and Rizzardi, G.P. and Fleury, S. and Lipp, M. and Foerster, R. and Rowland-Jones, S. and Sekaly, R.P. and McMichael, A.J. and Pantaleo, G.
The draft sequences. Filling in the gaps.
Bork, P. and Copley, R.
Lander, E.S. and Linton, L.M. and Birren, B. and Nusbaum, C. and Zody, M.C. and Baldwin, J. and Devon, K. and Dewar, K. and Doyle, M. and FitzHugh, W. and Funke, R. and Gage, D. and Harris, K. and Heaford, A. and Howland, J. and Kann, L. and Lehoczky, J. and LeVine, R. and McEwan, P. and McKernan, K. and Meldrim, J. and Mesirov, J.P. and Miranda, C. and Morris, W. and Naylor, J. and Raymond, C. and Rosetti, M. and Santos, R. and Sheridan, A. and Sougnez, C. and Stange-Thomann, N. and Stojanovic, N. and Subramanian, A. and Wyman, D. and Rogers, J. and Sulston, J. and Ainscough, R. and Beck, S. and Bentley, D. and Burton, J. and Clee, C. and Carter, N. and Coulson, A. and Deadman, R. and Deloukas, P. and Dunham, A. and Dunham, I. and Durbin, R. and French, L. and Grafham, D. and Gregory, S. and Hubbard, T. and Humphray, S. and Hunt, A. and Jones, M. and Lloyd, C. and McMurray, A. and Matthews, L. and Mercer, S. and Milne, S. and Mullikin, J.C. and Mungall, A. and Plumb, R. and Ross, M. and Shownkeen, R. and Sims, S. and Waterston, R.H. and Wilson, R.K. and Hillier, L.W. and McPherson, J.D. and Marra, M.A. and Mardis, E.R. and Fulton, L.A. and Chinwalla, A.T. and Pepin, K.H. and Gish, W.R. and Chissoe, S.L. and Wendl, M.C. and Delehaunty, K.D. and Miner, T.L. and Delehaunty, A. and Kramer, J.B. and Cook, L.L. and Fulton, R.S. and Johnson, D.L. and Minx, P.J. and Clifton, S.W. and Hawkins, T. and Branscomb, E. and Predki, P. and Richardson, P. and Wenning, S. and Slezak, T. and Doggett, N. and Cheng, J.F. and Olsen, A. and Lucas, S. and Elkin, C. and Uberbacher, E. and Frazier, M. and Gibbs, R.A. and Muzny, D.M. and Scherer, S.E. and Bouck, J.B. and Sodergren, E.J. and Worley, K.C. and Rives, C.M. and Gorrell, J.H. and Metzker, M.L. and Naylor, S.L. and Kucherlapati, R.S. and Nelson, D.L. and Weinstock, G.M. and Sakaki, Y. and Fujiyama, A. and Hattori, M. and Yada, T. and Toyoda, A. and Itoh, T. and Kawagoe, C. and Watanabe, H. and Totoki, Y. and Taylor, T. and Weissenbach, J. and Heilig, R. and Saurin, W. and Artiguenave, F. and Brottier, P. and Bruls, T. and Pelletier, E. and Robert, C. and Wincker, P. and Rosenthal, A. and Platzer, M. and Nyakatura, G. and Taudien, S. and Rump, A. and Yang, H.M. and Yu, J. and Wang, J. and Huang, G.Y. and Gu, J. and Hood, L. and Rowen, L. and Madan, A. and Qin, S.Z. and Davis, R.W. and Federspiel, N.A. and Abola, A.P. and Proctor, M.J. and Myers, R.M. and Schmutz, J. and Dickson, M. and Grimwood, J. and Cox, D.R. and Olson, M.V.
Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III.
Gonczy, P. and Echeverri, G. and Oegema, K. and Coulson, A. and Jones, S.J. and Copley, R.R. and Duperon, J. and Oegema, J. and Brehm, M. and Cassin, E. and Hannak, E. and Kirkham, M. and Pichler, S. and Flohrs, K. and Goessen, A. and Leidel, S. and Alleaume, A.M. and Martin, C. and Ozlu, N. and Bork, P. and Hyman, A.A.
ClC-5 Cl- -channel disruption impairs endocytosis in a mouse model for Dent's disease.
Piwon, N. and Guenther, W. and Schwake, M. and Boesl, M.R. and Jentsch, T.J.
The mammalian sodium channel BNC1 is required for normal touch sensation.
Price, M.P. and Lewin, G.R. and McIlwrath, S.L. and Cheng, C. and Xie, J.H. and Heppenstall, P.A. and Stucky, C.L. and Mannsfeldt, A.G. and Brennan, T.J. and Drummond, H.A. and Qiao, J. and Benson, C.J. and Tarr, D.E. and Hrstka, R.F. and Yang, B.L. and Williamson, R.A. and Welsh, M.J.
Kainate receptors and synaptic plasticity.
Nicoll, R.A. and Mellor, J. and Frerking, M. and Schmitz, D.
A chemokine-driven positive feedback loop organizes lymphoid follicles.
Ansel, K.M. and Ngo, V.N. and Hyman, P.L. and Luther, S.A. and Foerster, R. and Sedgwick, J.D. and Browning, J.L. and Lipp, M. and Cyster, J.G.
A function for dysfunction - Ion channels and disease.
Distinguished scientists back Germany's DFG . .
Jahn, R. and Boeck, A. and Breiner, K.M. and Breunig, K.D. and Bujard, H. and Campos-Ortega, J. and Ganten, D. and Grummt, I. and Gruss, P. and Goridis, C. and Huber, R. and Hoch, M. and Jaeckle, H. and Kahmann, R. and Koch-Brandt, C. and Leptin, M. and Michel, H. and Noegel, A. and Neher, E. and Nuesslein-Volhard, C. and Pfanner, N. and Sandhoff, K. and Schoen, A. and Schwille, P. and Simons, K. and Zrenner, E.
A constitutively open potassium channel formed by KCNQ1 and KCNE3.
Schroeder, B.C. and Waldegger, S. and Fehr, S. and Bleich, M. and Warth, R. and Greger, R. and Jentsch, T.J.
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions.
Sallusto, F. and Lenig, D. and Foerster, R. and Lipp, M. and Lanzavecchia, A.
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP.
Yeung, K. and Seitz, T. and Li, S.F. and Janosch, P. and McFerran, B. and Kaiser, C. and Fee, F. and Katsanakis, K.D. and Rose, D.W. and Mischak, H. and Sedivy, J.M. and Kolch, W.
The mahogany protein is a receptor involved in suppression of obesity.
Nagle, D.L. and McGrail, S.H. and Vitale, J. and Wolf, E.A. and Dussault, B.J. and DiRocco, L. and Holmgren, L. and Montagno, J. and Bork, P. and Huszar, D. and Fairchild-Huntress, V. and Ge, P. and Keilty, J. and Ebeling, C. and Baldini, L. and Gilchrist, J. and Burn, P. and Carlson, G.A. and Moore, K.J.
ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28.
Hutloff, A. and Dittrich, A.M. and Beier, K.C. and Eljaschewitsch, B. and Kraft, R. and Anagnostopoulos, I. and Kroczek, R.A.
Moderate loss of function of cyclic-AMP-modulated KCNQ2/KCNQ3 K+ channels causes epilepsy.
Schroeder, B.C. and Kubisch, C. and Stein, V. and Jentsch, T.J.
Signal transduction. Docking IkappaB kinases.
Csk controls antigen receptor-mediated development and selection of T-lineage cells.
Schmedt, C. and Saijo, K. and Niidome, T. and Kuehn, R. and Aizawa, S. and Tarakhovsky, A.
Microdomains of GPI-anchored proteins in living cells revealed by crosslinking.
Friedrichson, T. and Kurzchalia, T.V.
Electrical coupling underlies high-frequency oscillations in the hippocampus in vitro.
Draguhn, A. and Traub, R.D. and Schmitz, D. and Jefferys, J.G.R.
CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells.
Henn, V. and Slupsky, J.R. and Graefe, M. and Anagnostopoulos, I. and Foerster, R. and Mueller-Berghaus, G. and Kroczek, R.A.
Severe neuropathies in mice with targeted mutations in the ErbB3 receptor.
Riethmacher, D. and Sonnenberg-Riethmacher, E. and Brinkmann, V. and Yamaai, T. and Lewin, G.R. and Birchmeier, C.
More hippocampal neurons in adult mice living in an enriched environment.
Kempermann, G. and Kuhn, H.G. and Gage, F.H.
Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation.
Plemper, R.K. and Bohmler, S. and Bordallo, J. and Sommer, T. and Wolf, D.H.
Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis.
Weidner, K.M. and Dicesare, S. and Sachs, M. and Brinkmann, V. and Behrens, J. and Birchmeier, W.
Two physically distinct pores in the dimeric ClC-0 chloride channel.
Ludewig, U. and Pusch, M. and Jentsch, T.J.
The C5a chemoattractant receptor mediates mucosal defence to infection.
Hoepken, U.E. and Lu, B. and Gerard, N.P. and Gerard, C.
Functional interaction of beta-catenin with the transcription factor LEF-1.
Behrens, J. and von Kries, J.P. and Kuehl, M. and Bruhn, L. and Wedlich, D. and Grosschedl, R. and Birchmeier, W.
A common molecular basis for three inherited kidney stone diseases.
Lloyd, S.E. and Pearce, S.H. and Fisher, S.E. and Steinmeyer, K. and Schwappach, B. and Scheinman, S.J. and Harding, B. and Bolino, A. and Devoto, M. and Goodyer, P. and Rigden, S.P. and Wrong, O. and Jentsch, T.J. and Craig, I.W. and Thakker, R.V.
Requirement of mammalian DNA polymerase-beta in base-excision repair.
Sobol, R.W. and Horton, J.K. and Kühn, R. and Gu, H. and Singhal, R.K. and Prasad, R. and Rajewsky, K. and Wilson, S.H.
Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein.
Brocke, S. and Gijbels, K. and Allegretta, M. and Ferber, I. and Piercy, C. and Blankenstein, T. and Martin, R. and Utz, U. and Karin, N. and Mitchell, D. and Veromaa, T. and Waisman, A. and Gaur, A. and Conlon, P. and Ling, N. and Fairchild, P.J. and Wraith, D.C. and Ogarra, A. and Fathman, C.G. and Steinman, L.
Multiple essential functions of neuregulin in development.
Meyer, D. and Birchmeier, C.
Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud.
Bladt, F. and Riethmacher, D. and Isenmann, S. and Aguzzi, A. and Birchmeier, C.
Scatter factor/hepatocyte growth factor is essential for liver development.
Schmidt, C. and Bladt, F. and Goedecke, S. and Brinkmann, V. and Zschiesche, W. and Sharpe, M. and Gherardi, E. and Birchmeier, C.
Gating of the voltage-dependent chloride channel CIC-0 by the permeant anion.
Pusch, M. and Ludewig, U. and Rehfeldt, A. and Jentsch, T.J.
Casari, G. and Andrade, M.A. and Bork, P. and Daruvar, A. and Ouzounis, C. and Schneider, R. and Tamames, J. and Valencia, A. and Sander, C.
Distinct functions for the two importin subunits in nuclear protein import.
Goerlich, D. and Vogel, F. and Mills, A.D. and Hartmann, E. and Laskey, R.A.
Implications for dorsoventral axis determination from the zebrafish mutation janus.
Abdelilah, S. and Solnica-Krezel, L. and Stainier, D.Y. and Driever, W.
NMDA receptors and activity-dependent tuning of the receptive fields of spinal cord neurons.
Lewin, G.R. and Mckintosh, E. and McMahon, S.B.
Evolutionary conservation of components of the protein translocation complex.
Hartmann, E. and Sommer, T. and Prehn, S. and Goerlich, D. and Jentsch, S. and Rapoport, T.A.
Universal nucleic acid-binding domain revealed by crystal structure of the B. subtilis major cold-shock protein.
Schindelin, H. and Marahiel, M.A. and Heinemann, U.
Inhibition of neurotransmitter release by C2-domain peptides implicates synaptotagmin in exocytosis.
Bommert, K. and Charlton, M.P. and DeBello, W.M. and Chin, G.J. and Betz, H. and Augustine, G.J.
A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic mice.
Schedl, A. and Montoliu, L. and Kelsey, G. and Schutz, G.
Qa-2 molecules are peptide receptors of higher stringency than ordinary class I molecules.
Roetzschke, O. and Falk, K. and Stevanovic, S. and Grahovac, B. and Soloski, M.J. and Jung, G. and Rammensee, H.G.
Benzodiazepine-induced motor impairment linked to point mutation in cerebellar GABAA receptor.
Korpi, E.R. and Kleingoor, C. and Kettenmann, H. and Seeburg, P.H.
A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum.
Sommer, T. and Jentsch, S.
Regions involved in the opening of CIC-2 chloride channel by voltage and cell volume.
Gruender, S. and Thiemann, A. and Pusch, M. and Jentsch, T.J.
Molecular identification of the gene responsible for congenital nephrogenic diabetes insipidus.
Rosenthal, W. and Seibold, A. and Antaramian, A. and Lonergan, M. and Arthus, M.F. and Hendy, G.N. and Birnbaumer, M. and Bichet, D.G.
Molecular cloning of the receptor for human antidiuretic hormone.
Birnbaumer, M. and Seibold, A. and Gilbert, S. and Ishido, M. and Barberis, C. and Antaramian, A. and Brabet, P. and Rosenthal, W.
A chloride channel widely expressed in epithelial and non-epithelial cells.
Thiemann, A. and Gruender, S. and Pusch, M. and Jentsch, T.J.
Bork, P. and Ouzounis, C. and Sander, C. and Scharf, M. and Schneider, R. and Sonnhammer, E.
A protein of the endoplasmic reticulum involved early in polypeptide translocation.
Goerlich, D. and Hartmann, E. and Prehn, S. and Rapoport, T.A.
Hartmann, E. and Rapoport, T.A. and Prehn, S.
Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappaB.
Wulczyn, F.G. and Naumann, M. and Scheidereit, C.
Inactivation of muscle chloride channel by transposon insertion in myotonic mice.
Steinmeyer, K. and Klocke, R. and Ortland, C. and Gronemeier, M. and Jockusch, H. and Gruender, S. and Jentsch, T.J.
Primary structure and functional expression of a developmentally regulated skeletal muscle chloride channel.
Steinmeyer, K. and Ortland, C. and Jentsch, T.J.
Chromosomal mapping of two genetic loci associated with blood-pressure regulation in hereditary hypertensive rats.
Hilbert, P. and Lindpaintner, K. and Beckmann, J.S. and Serikawa, T. and Soubrier, F. and Dubay, C.J. and Cartwright, P. and De Gouyon, B. and Julier, C. and Takahashi, S. and Vincent, M. and Ganten, D. and Georges, M. and Lathrop, G.M.
Assignment of G-protein subtypes to specific receptors inducing inhibition of calcium currents.
Kleuss, C. and Hescheler, J. and Ewel, C. and Rosenthal, W. and Schultz, G. and Wittig, B.
A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene.
Kitamura, D. and Roes, J. and Kühn, R. and Rajewsky, K.
Protein translocation. A bacterium catches up.
The GTP-binding protein, Go, regulates neuronal calcium channels.
Hescheler, J. and Rosenthal, W. and Trautwein, W. and Schultz, G.
This list was generated on Tue Apr 23 02:35:36 2019 CEST.

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The ability of an inventor to profit from an invention for a limited time, while also sharing the advances with the world to further knowledge, is the genius of the patent system. The availability of patent protection has done much to advance the economy of the United States and other nations that have shown respect for property rights, including intellectual property. Without that option, advances in knowledge will tend to be held as closely-guarded trade secrets, not published knowledge, which was one of the key characteristics of the Medieval Ages and earlier IP-deprived times. For this reason, we should be concerned at trends in the US where patents are increasingly under attack in the courts and where the ability to get patents in a reasonable time is increasingly difficult at the USPTO.
Innovation fatigue due to inadequate intellectual property rights and property rights in general occurs in many other nations today, and is strongly correlated with economic difficulty in such nations. Hernando de Soto, a Peruvian economist and winner of many awards such as the 2006 Innovation Award from The Economist for the promotion of property rights and economic development, has shown that lack of property rights has been a key factor in keeping poor nations poor. It is respect of property rights that creates the means for men to be equal in opportunity. Intellectual property rights are part of that, and when they are in jeopardy, we should be concerned.
In Brazil, for example, a nation with tremendous potential for further economic development, recent government actions related to a trade dispute with the US over cotton threaten to reduce the value of US patents held by people in Brazil. In “Brazil Close to Declaring War on US IP” over at IAM Magazine, we read about the dangerous actions being taken by the Brazilian government. There may be many long-term costs for whatever short-term gains they obtain. This could harm innovation and economic development in that nation.
One example in the US of the attack on patent rights comes from the recent court case Association for Molecular Pathology v. USPTO in which a body of patents obtained by Myriad Genetics (NASDAQ:MYGN) has been declared invalid by a judge using dubious arguments presented by the ACLU. I am especially troubled that the patents were declared invalid for not treating patentable subject matter under 35 U.S.C. § 101.
What is most alarming about Judge Sweet’s opinion is his characterization (or more appropriately mischaracterization) of the CCPA’s Bergy case. Judge Sweet makes numerous quotes from Judge Rich’s opinion in Bergy on how 35 U.S.C. § 101 should be interpreted. But what Judge Sweet neglects to point out is that Judge Rich ruled in Bergy that a biologically pure culture was deemed to be patent-eligible under 35 U.S.C. § 101. Why did Judge Sweet neglect to point out this highly relevant fact? Instead, if the holding in Bergy is considered in appropriate context, it supports Myriad’s “isolated” BRCA1 and BRCA2 gene sequences as being at least patent-eligible under 35 U.S.C. § 101 because they don’t exist in nature and cannot exist without significant human intervention. . . .
In the end, it is my considered opinion that Judge Sweet knew the result he wanted to reach (i.e., invalidate Myriad’s patents), and simply cobbled together a justification for it. (Treating the claims in Myriad’s patents are a “lawyer’s trick” also doesn’t suggest impartiality.) If nothing else, there is enough of a dispute about the essential facts needed to reach Judge Sweet’s conclusion to deny the plaintiff’s motion for summary judgment of invalidity based on 35 U.S.C. § 101. That Judge Sweet needed to spend 152 pages trying to justify his grant of plaintiff’s motion for summary judgment speaks volumes about why this grant was inappropriate.
Years ago in exploring emerging technology in consumer products, I was impressed with the development of the foaming pump from Airspray N.V. This pump has become widespread, allowing liquid soap and other solutions to emerge from a pump dispenser as a rich foam without the need for propellants. Cool product. I’ve also looked over some of the associated patent estate and have been impressed again. Robert Brands was the CEO of Airspray and took that pump to the world. Through his experiences at Airspray, then at Rexam after they acquired Airspray, and now as an innovation coach, Robert knows a lot about real-world innovation. He has shared this knowledge in a new book, Robert’s Rules of Innovation: A 10-Step Program for Corporate Survival .
Robert’s Rules of Innovation offers a fresh perspective on innovation processes and approaches from an experienced leader who knows what it takes to bring products to the market. This book draws upon not only his experience, but the experience and wisdom of many others that he has turned to for various sections of the book.
developing intellectual property in “Patently Obvious,” the title of Chapter 6, which offers basic information on patents, trademarks, and copyrights.
An innovation checklist is presented in Chapter 8 to summarize some of the teachings.
Appendices provide detailed flow charts on new product development processes that may be helpful to those implementing such systems.
The book products a broad and useful overview from an experienced entrepreneur and consultant in innovation and new product development. The focus may be heavy on the consumer products side of innovation. The beginning-to-end scope of the book also means that information tends to be at a broad, general level. Some of the bullet points may leave readers wondering exactly what is meant or how to follow the instructions.
While some of the information, naturally, is already out there in the literature, I liked the selection of 10 principles to focus on and especially appreciated the contributions in the chapters on the innovation audit and multinational teams. Robert’s experience with multinational teams can provide a helpful foundation for others in this increasingly global business environment.
The book may be most helpful to corporate leaders and entrepreneurs launching companies focused on innovative new products, but there are gems for innovators and champions of innovation at all levels.
Congratulations to Robert Brands for this addition to the literature on innovation!
Nussbaum on Design (BusinessWeek) has a though-provoking column that mentions several innovation principles from designer Diego Rodriquez. One of these is “Killing good ideas is a good idea.” That’s the kind of counter-intuitive blasphemy that merits reflection. Of course, developing good ideas is essential, but without the killing phase, good ideas can lead to “idea cancer.” Ideas from late-stage idea cancer strangle many organizations and many minds–when ideas grow without control, unregulated and unchecked by proper objectives and reality. Ideas can metastasize and choke the arteries of business, cloud the mind, and weaken all life support systems in the end, unless they are regulated and killed at the appropriate time. So many great failures begin with good ideas, and lots of them.
Innovation is often more about execution and planning than idea generation. A weak idea, implemented ITERATIVELY with the right talent, can be adjusted based on feedback from the system (e.g., the market) and become successful. Even mediocre ideas can beat good ideas if there are great skills, good leaders, and good execution. But add an occasional great idea to the mix and the success can be remarkable, if the dream isn’t cluttered with lots of distracting good ideas along the way.
In recent years, scientists have been astounded to discover that the visible universe represents just a tiny fraction of the matter and energy that governs the cosmos. Based on the motion of stars and galaxies, strange “dark matter” must be present, increasing the gravitational tug on celestial bodies more than can be accounted for by visible matter. Further, based on the surprising discovered that the universe is expanding, not contracting under its own gravitational pull as expected, scientists have proposed that a strange, repulsive “dark energy” fills the cosmos countering gravity. The combined effect of these unseen entities, dark energy and dark matter, are so great, that they account for 96% of the matter and energy of the universe. In other words, the visible universe that we used to think is all there is actually is only a tiny fraction of what is there. What we see in the “cosmic org chart” accounts for only 4% of what really influences the cosmos.
It’s that way in the business world. too. Companies can create tidy org charts and draft neat process maps to describe how they work, but the unseen reality outside the visible systems may be what really dominates operations. Increasingly, experts in knowledge management are learning that easily overlooked and often invisible intangibles can dominate corporate value and performance. Numerous intangible transactions may be essential to the success of a company, including casual information sharing between trusted friends, helpful exchanges of tips and best practices between employees or between external partners and internal employees, or loyalty that is gained when people are included in decision making. The invisible linkages and hard-to-observe exchanges in a company’s internal an external ecosystems may be the real engines of value creation, regardless of what is on a process map or workstream. By not understanding the value of such intangibles, corporations can easily break key linkages and crush subtle engines of value creation.
Many companies focus on their “value chains” – a term popularized by Michael Porter in his seminal 1985 work, Competitive Advantage. The value chain describes the linear chain of events as materials and products move from sourcing through manufacturing and out to the market. It is a highly useful paradigm for manufacturing and was highly applicable to much of the economy in the era when Porter was doing his research. But since that time, the explosion of the knowledge economy has changed the way we work and create value. One of my favorite authors, Verna Allee, a revolutionary expert in knowledge management, has detailed the move from the value chain to modern ecosystems and Value Networks in her book, The Future of Knowledge: Increasing Prosperity through Value Networks (Burlington, MA: Elsevier Science, 2003). Verna Allee and Associates have introduced a clever, methodical tool called Value Network Analysis for analyzing and visualizing the transactions of intangibles and tangibles that affect a business.
After my training in Value Network Analysis by Verna and her associate, Oliver Schwabe, an exciting new perspective on business and human behavior opened up. I have been highly impressed with the power of Value Network Analysis and the insights that it can rapidly deliver for a company. The Value Network Analysis work that Innovationedge has done as part of larger projects for some of our clients has been a very exciting part of my work since joining Cheryl Perkins’ exciting company. We value the tool enough that we had Verna Allee speak at the 2008 CoDev conference to introduce other business leaders to the basic concepts behind Value Network Analysis. I’m very pleased to see a community emerging of people using Value Network Analysis and developing exciting tools for it.
Part of the initial output in Value Network Analysis are maps, called “holomaps,” showing human entities as nodes and transactions of tangible or intangible items between them. There is much that can be learned from such holomaps – a topic for later discussion. For now I’ll show you two sample holomaps I created to illustrate simple ecosystems. One shows several external nodes around a manufacturer and the other shows some structure within part of a corporation. For simplicity, the maps lack all the labels explaining the transactions.
One interesting approach is to use the “holomaps” you get in Value Network Analysis as tools for “what if” scenarios to explore what new partners might do for your business model, or what new business models might do for your ecosystem. Using holomaps to explore innovation ecosystems is a particularly fruitful approach for those doing open innovation and wondering who should be in their external ecosystem.
We have further information on this topic that we’d be happy to share with you. It’s certainly something you should look at to understand how business really works.
One of the real champions of innovation and entrepreneurship, Brian Fried, has created a successful new radio program to meet the needs of inventors and entrepreneurs: Got Invention Radio at GotInvention.com. It’s a one-hour show every Thursday night at 7:00 p.m. CST (if you’re in China or Singapore, for example, that should be 8 a.m. Friday morning–the perfect way to start your day!) I’m the next guest this Thursday night. I’ll be speaking about intellectual property, with practical tips for inventors who want to get quality patent protection. There are some pitfalls to avoid and some tips you need to know about. A quality patent can make all the difference for the long-term success of a product or business, so tune in and join the conversation.
At least two callers will receive free copies of the book, Conquering Innovation Fatigue. Please mention this blog when you call!
Go to Gotinvention.com/shows and click on the green area in the upper right-hand portion of the screen to launch your media player and listen. To be a caller, dial 877-474-3307. Please join us this Thursday night, March 18.
The following week, March 25, you can hear Cheryl Perkins, CEO of Innovationedge. Don’t miss that one, either!
Hey, innovation fans, thought I’d share with you a simple innovation you can use if you like to freeze fruit. I found some delicious pineapples on sale at Aldi for 99 cents and bought several. Chopped them up into nice pieces and froze them. Challenge is, they stick together and form a solid frozen mass. Commercial frozen fruit can be agitated or separated during freezing to prevent welding of pieces together, but how can a consumer do it? I bet this is already out there, but a handy solution I came up with is to coat the fruit with a little corn syrup before freezing. Depending on how cold your freezer is, the fruit may still become welded together, but it’s much easier to loosen the mass into individual pieces.
Just enjoyed a delicious chunk of frozen pineapple, courtesy of my corn-syrup pretreatment method. OK, not much of an innovation, but still, enjoy!
One of the nine major innovation fatigue factors that we treat in Conquering Innovation Fatigue is theft of the invention, of the IP, or other assets. One of the most painful and most common sources of theft of an invention is from partners such as vendors or customers. One apparent example is the dispute between Woodstream Corp. and Agrizap, Inc., a case that went to district court and then on appeal to the Federal Circuit Court. Again, there are always two sides to these stories, and we encourage people not to judge losers of legal battles too harshly, for truth and justice are not always the product of courts. But the apparent facts of the case, as reported in public documents, illustrate the kind of problems that many inventors face and need to be protected against.
Agrizap, Inc. had developed a rat killer based on electrocution. It was patented in US Pat. No. 5,949,636. Woodstream, the maker of the Victor® brand pest control products, approached and developed a partnership with Agrizap. During negotiations under a non-disclosure agreement, Woodstream sent samples of the Agrizap product to Chinese manufacturers. Agrizap learned of this and challenged their motives, but a vice president of Woodstream assured Woodstream that the action was simply to obtain a price quote for use in negotiation with Agrizap and was permitted under a particular section of the non-disclosure agreement. However, it appears that they were looking for help in making their own product. Woodstream soon licensed the patent from Agrizap to allow Woodstream to sell the product to a limited group of companies such as Home Depot and Lowe’s. Agrizap agreed not to compete in those markets. They provided Woodstream with products, not knowing that Woodstream was working on developing their own version of the same. Within three years of the partnership, they were competing directly with Agrizap with their own version of the product.
In this case, unfortunately, the activities of Woodstream forced Agrizap to sue and thereby put their patent at risk. Had Woodstream been more forthcoming, Agrizap might have been able to license the patent more broadly or continue using it to generate revenue. One can argue that eliminating an invalid patent is a public service, and that may be the case, but the invalidity is painful when it comes from rules that change midstream, adding new uncertainties for patent owners. And in any case, the apparent misrepresentation by Woodstream resulted in substantial loss for Agrizap. It gave Woodstream several years of market penetration before they launched their own product, when it would have been much better for Agrizap–had they known of Woodstream’s intent–to simply enter the market directly and build momentum before Agrizap had time to reverse engineer their product. No one wants to form a partnership with someone who secretly plans to turn around and compete directly against you.
Choose your partners and friends carefully. The ones with poor ethics will usually lead to regret and loss. Make sure you have solid documentation of your agreements and understandings, in addition to strong patents, in order to protect your interests in spite of the uncertainties of law.
What are the biggest technologies to focus on?
With some 800 to 1,000 patents within A*Star to tap on, new Exploit Technologies CEO Philip Lim would be hard-pressed to name a few.
Still, gamely, he does point out a couple, during an interview.
One area is nano-imprinting lithography (NIL), a manufacturing process that is set to bring many benefits to making electronics that control, say, the liquid from an inkjet printer, or even for biomolecular sorting devices in the emerging bio-sciences equipment market.
Another area is ultrawideband (UWB) technology, a radio technology that promises to transfer audio and video over the air with speeds that are more common on wired connections.
With it, hi-fi equipment would one day do away with messy cables used to connect them together.
Taking over from long-time A*Star stalwart Boon Swan Foo, Philip says his main task is to group together complimentary expertise in the hottest fields, so as to come up with more products that can go to market fast.
He also intends to incentivise people to play as a team. By combining knowledge of market requirements, as well as the expertise that A*Star has, Exploit can help map out emerging and potentially viable areas which Singapore can focus on, he says.
For example, with UWB, the expertise of two A*Star institutes – the Institute for Infocomm Research (I²R) for its UWB design, and the Institute of Microelectronics (IME) for its expertise in manufacturing electronics – can easily be combined.
“We want to be more outcome-focused and customer-focused in the way we do things,” he says, referring to a more streamlined approach to getting technologies out from the lab bench to retail shelves.
The dollar value of licenses made possible with Exploit, he notes, does not count the multiplier effect of the entire value chain of a technology. For example, technology behind a simple, low-cost keypad can be used in a much more expensive handphone, and has more value than its mere licensing fee.
“If we can generate ‘economic outcomes’, like sustainable innovation and more jobs for Singapore, then we’ve done our jobs,” says Philip, of Exploit.
Economic outcomes are what it’s all about. Philip wisely recognizes that successful tech transfer of government-funded R&D can result in long-term economic value for Singapore. They are focused on a long-term plan that will bring more companies and more jobs to Singapore to take advantage of the talent, the technology, and the culture of success that is being crafted.
One of the challenges for commercialization success in the Singaporean model will be continually crafting a portfolio of not just patents, but know-how and other intellectual assets that create synergy with the marketing story that fits the technology and business opportunities being developed. The marketing perspective needs to be brought into the technology plans and the IP strategy to create portfolios that encompass winning business models and can quickly give a partner a competitive advantage. The world beyond 2010 increasingly will rely on ecosystems of partnerships for success, united by the energy of clever business models in which marketing savvy and IP prowess go hand-in-hand. A*STAR and Exploit Technologies have the vision, and they are continuing to build the discipline and partnerships to make it happen. I look forward to watching this story unfold in the coming years.
Congratulations to Philip Lim and Exploit Technologies, and best wishes in your path forward to innovation success!
The latest issue of Consumer Goods Technology has a story that indirectly reveals some important secrets of successful innovation. The article is the cover story by Alarice Padilla, “Game-Changing Innovation: The Maker of Louisville Slugger Revolutionizes the Sporting Good Market with Bionic Glove Technology,” which describes the rise of a remarkable new glove that gives athletes better control. The glove has a unique padding system that fills recesses in the fingers and palm to give better contact with what the hand is holding. This results in a better, less stressful grip.
What I’d like to emphasize is that this innovation was the result of open innovation that began with a random encounter. Bill Clark of Hillerich and Bradsby Company, the company behind the Louisville Slugger and Powerbuilt Golf, was visiting the Louisville Slugger Museum when he met James Kleinert, a famous orthopedic hand surgeon. They began talking, and this would later lead to collaboration and the successful introduction of the only sports glove on the market designed by an orthopedic surgeon.
The real secrets for success behind this story, in my opinion, involve efforts to build and maintain relationships. First, Bill Clark wasn’t sitting at his desk. He got out into an environment where he could meet outsiders that might share some interest in the kind of products his company made. Then he took the initiative to talk with others and learn from them. When he found someone interesting through a chance encounter, he obviously took the initiative to follow up and keep that relationship alive long enough to explore the possibility of learning from or working with the new contact. I wish more had been reported on these steps, but it’s clear that it began with a seemingly random encounter enhanced with follow-up and and a willingness to collaborate for innovation.