With respect to inflammatory markers, from the limited trial **data** available, EPA decreased only IL-6 concentrations, whilst DHA decreased IL-6, IL-18, CRP, and TNF-α concentrations in subjects with subclinical inflammation. However, neither omega-3 PUFA was effective in lowering inflammatory markers in hypertensive-treated diabetics. Both EPA and DHA significantly lowered biomarkers of oxidative stress in hyperlipidaemic men as well as in hypertensive-treated diabetics.