This was a clinical trial study which was performed to evaluate the effect of family-centered empowerment model on quality of life of the 86 children aged 6-12 years with thalassemia major who referred to Kerman Thalassemia Center in spring 2010. In this study, the subjects were divided into case and control groups according to the days they were referred to Specials Diseases Center. The children who participated in this study had referred to thalassemia center along with their parents and also had a file in this center and also expressed their willingness and readiness to participate in the study. Data collection tools included a demographic **data** questionnaire and pediatric quality of life questionnaire 4th ed. This questionnaire was an assessment tool for general quality of life of the children aged 6-12 years and consisted of 23 questions in four domains of physical performance (8 questions), emotional performance (5 questions), social performance (5 questions) and school performance (5 questions).