Currently, there is a lack of validation studies to bring source space connectivity into clinical practice. Even M/EEG source localization is still only performed in a modest number of centers worldwide, e.g., in the E-PILEPSY consortium electromagnetic source localization is only used at 12 out of 25 centers in the presurgical evaluation (85). Calculating source space connectivity is more complex than source localization alone. Given that the integration of source localization has already proven to be difficult in clinical practice, it can be anticipated that this will be an even larger challenge for source space connectivity. First, well designed prospective studies should show that source space connectivity has clear added value compared to the visual analysis of the electrophysiologist today on a patient specific level. Later, the methods should be available in standardized software with appropriate clearance for clinical use. Software for clinical use must come along with high usability, so that clinical-technical staff can do the necessary steps of processing (a) without risk of running into pitfalls that are common in source imaging and (b) within a workable time range, which is notoriously limited in clinical contexts. Next to this, standardized paradigms must be defined and tested, similarly to neuropsychological tests, in order to determine whether eloquent areas can be mapped by source connectivity analysis in pre-surgical evaluation. These paradigms must take into account the fact that network analyses require temporal information. Indeed, source-level connectivity needs different **data** properties than simple source-transformation of single events such as peaks of event related components. Only when all these limitations are overcome, can source connectivity be considered in clinical practice to assist in patient treatment and follow-up.