For MALDI IMS **data** analysis, **data** was log2 transformed before further statistical analysis and a linear model was fitted using both treatment and analyses run as variables. For multiple testing correction of the p-values the [30] was used. An adjusted pvalue ,0.05 was considered as significant. Statistical analysis was done using the statistical environment R [31] and the package Limma [32]. Linear regression was used for its representative value but Pearson correlation was used to ascertain the nature of the relationship.