Clinical **data** were collected from medical records. The anthracycline cumulative dose was measured in doxorubicin (DOX) equivalents (mg/m 2 ), that is, daunorubicin total dose multiplied by 0.5, epirubicin total dose multiplied by 0.6, idarubicin total dose multiplied by 5, and mitoxantrone total dose multiplied by 4 (13). LV ejection fraction (LVEF) was measured by 2-dimensional echocardiography at enrollment and at 1 and 2 years of follow-up and analyzed at an independent core laboratory (12). All participants provided a blood sample at enrollment.