In the case of the STRING database v11, we applied the same procedure described above to remove interactions between proteins annotated to separate intra and intercellular domains. In total, the 3 resulting PPI networks contained 8.434 nodes and 303,600 edges (PC1), 12,649 nodes and 464,091 edges (PCv12), and 12,921 nodes and 3,594,088 edges (STRING), representing 0.8%, 0.6% and 4% of the maximum possible number of edges. We note that the filtering with protein cellular localization **data** reduces the dimensionality of the PPI networks from around 18000-20000 genes to the approximately 8000 or 12000 genes noted above.