Transcription factor activities are sometimes, but not always, correlated with the gene expression of the factor. We compared the calculated transcription factor activities with the gene expression **data** for each factor ( Figure 2B). NFKB1, RELA, STAT1, STAT3 and MYC showed strong positive correlation between activities and expression (correlation coefficient c > 0.56), possibly due to auto-or cross-regulation. For example, NFKB1 activity and expression are tightly correlated (c = 0.6022), possibly because the NF-B p65:p50 complex can regulate NFKB1 [38,39]. STAT1 activity and expression are also strongly correlated (c = 0.8362), which might relate to the transcriptional effect of STAT3 on STAT1 expression [40], particularly given that STAT1 and STAT3 have highly correlated activities ( Figure 2C, c = 0.9329). On the other hand, the activities and expression show lower or no correlation for IRF3, JUN, FOS and CREB (-0.15 <c < 0.37).