When it comes to the use of RBCs in carious lesion, current literature does not provide **data** about the type of RBCs that should be used in leukemia patients. Therefore, the aim of our research was to analyze, in vitro, the degradation process of resin-based composites by determining the sorption and solubility properties and evaluating the amount of residual monomer in saliva of leukemia patients before starting chemotherapy regiments. This approach reflects the properties of dental composite, as well as certain aspects of the potential side-effects caused by the patient's pathology. Additionally, the subject addressed has a practical connotation, since dental practitioners should be constantly informed and aware about the properties of dental materials and should personalize the selection of restoration materials in accordance with the complexity of each clinical case [9].