Johannes Tröger conceptualized this work; he drafted the manuscript and edited the final version. Ebru Baykara contributed to the overall interpretation of the work and drafting of the manuscript. Elisa Mallick, Simona Schäfer, Louisa Schwed, and Mario Mina implemented the biomarker, analyzed the speech, conducted the statistical work, as well as drafted the methods and results sections of this article. Daphne ter Huurne and Nina Possemis acquired parts of the data, contributed to the clinical interpretation of the results, and revised the document. Jian Zhao oversaw the design of the V3 framework validation pipeline from a regulatory standpoint and revised the document. Nicklas Linz contributed to the overall concept of this research and revised the manuscript. Inez Ramakers is responsible for the DeepSpA study and **data** acquisition, drafted DeepSpA relevant parts of the document, and revised the manuscript. Craig Ritchie is the principal investigator of SPeAk, responsible for the concept and **data** acquisition, drafted SPeAk relevant parts of the document, and revised the manuscript.