From the dissolution data, the calculation of %DE with their respective 95% CI are illustrated in Figure 9. The average %DE for TZP-NC 1 and TZP-AqS were found to be 70.6 ± 3.4% and 56.2 ± 3.5% with mean dissolution times 2.9 ± 0.2 h and 4.3 ± 0.3 h, respectively. The 95% CI was found in the range of 13.3 to 15.8 (>±10%), indicating the differences in the dissolution/release profiles of the drug from the two formulations. Calculation of %DE provides information for the quantitative comparisons between the products. It is easier to interpret the **data** obtained through %DE than that of the difference and similarity factors [53]. Conclusively, the %DE is a better substitute for the single point dissolution measurement for the dissolved drugs during in vitro release study.