An integrated approach for the assessment of marine pollution generates large and heterogeneous datasets including variables with very different metrics and distributions. All of these must be considered when selecting the method for **data** analysis. In this Research Topic, Regoli et al. applied a Weight of Evidence (WOE) model to results from the monitoring of offshore platforms, based on multiple lines of evidence including chemical analyses and biological responses. The assessment of environmental quality was summarized in terms of hazard quotients, providing a useful tool for the application of risk assessment in environmental management. Lehtonen et al. assessed pollution impacts in coastal areas of Finland with a WOE approach, using caged mussels. The integration of chemical and biological effect **data** revealed that the health of marine organisms in the area of study is being altered by pollution. Parmentier et al. assessed the effects of tributyltin (TBT) on the brown shrimp (Crangon crangon) and suggest that long-term endocrine disruption effects was the reason for previously unexplained declines in C. crangon and other crustacean populations in the German Bight. Förlin et al. studied perch (Perca fluviatilis) populations at reference sites from the Swedish National Monitoring Program where a decline in fish health had been previously observed. Alterations in several biological responses, confirmed by mRNA expression levels, were related to higher concentrations of natural, bioactive brominated compounds measured in the perch, attributed to algal blooms in the Baltic Sea. Yang et al. studied the distribution and levels of persistent organic pollutants in surface sediments of Qingduizi Bay. Polychlorinated biphenyls (PCBs) and hexachlorocyclohexane (HCH) levels were attributed to their extensive historical use in adjacent areas. However, the DDT profile showed recent usage and fresh inputs from aquaculture activities, with levels that could be potentially toxic to marine organisms.