Supplementary Figure S1 . TALENs induce higher somatic indel rates than ZFNs in zebrafish embryos . ( a ) Data points represent somatic indel rates for each of the 84 ZFN and 34 TALEN pairs tested . Black bars indicate median somatic indel rate for each type of nuclease . Indel rates were significantly higher for TALENs compared to ZFNs ( p=5.1x10 -12 using Wilcoxon rank sum test ) . Black data points represent ZFNs and TALENs for which germline mutants were generated . Panel ( b ) shows data for nucleases that induced somatic indels at rates up to 1 % .    Figure S2 . The distribution of somatic indel size is similar for nucleases with different somatic indel rates . Somatic indels that were induced by ZFNs ( a ) and TALENs ( b ) have similar size distributions regardless of the indel rate . Median indel size and number of sequence reads are as follows .