The following are available online at https://www.mdpi.com/article/10 .3390/ph14050402/s1, Figure S1: 1H-NMR **data** information for 7α-acetoxy-6β-hydroxyroyleanone, Figure S2: HPLC chromatograms (270 nm) of P. hadiensis leaves showing the major compound, 7α-acetoxy-6β-hydroxyroyleanone, Figure S3: UV spectrum of 7α-acetoxy-6β-hydroxyroyleanone, Figure S4: Concentration-response curves (IC 50 µM) for 7α-acetoxy-6β-hydroxyroyleanone; Table S1: NMR spectroscopy **data** characterization, 1