According to preclinical studies, GABA B receptors modulate anxiety and depression-related behaviors (21), and baclofen may induce better results among AUD patients affected by anxiety and/or mood disorders through a reduction of the severity of these disorders. The present narrative mini-review was aimed at investigating the role of psychiatric comorbidity in explaining potential different responses to baclofen treatment among AUD patients. The results show that the majority of AUD patients treated with baclofen and described by the case reports, as well as the observational and retrospective studies, suffered from anxiety and/or mood disorders. This finding agrees with **data** of large epidemiological studies (14,60). However, the results of the present review also show that, despite these disorders being common among AUD patients, patients with severe mental disorders (including severe anxiety and mood disorders) were excluded by the randomized, controlled, trials (RCTs) conducted to evaluate the efficacy of baclofen to treat AUD. Therefore, these results do not allow us o evaluate whether baclofen efficacy is different in AUD patients with comorbid psychiatric disorders compared to those without. One RCT found that baclofen administration reduced alcohol consumption in anxious patients, but not in patients with low levels of anxiety (55). However, in this study, baclofen administration did not significantly reduce anxiety levels. A recent meta-analysis also found no difference between baclofen and placebo in reducing both depression and anxiety levels among AUD patients (64). The results of the present review may be useful to better understand these results. Indeed, both these studies (55,64) evaluated the efficacy of baclofen in modifying the severity of anxiety or depression among AUD patients not affected by severe mental disorders. In addition, the RCTs used different scales to measure the severity of anxiety and/or depression, such as self-reported rating scales (e.g., STAI, BDI, and ZUNG) and interviewer-rated scales (e.g., HAM-A, HAM-D, and MADRS). The exclusion of patients with severe mental disorders, and the variability in the scales adopted, prevents current meta-analyses to evaluate potential differences in baclofen efficacy in reducing the severity of the comorbid mental disorders. To reduce the variability, the interviewer-rated scales should be used rather than self-reported rating scales (65,66). Accordingly, it is desirable that future RCTs investigate the efficacy of baclofen in AUD patients affected by other mental disorders, using interviewer-rated scales to establish the effects on the severity of anxiety and/or depression.