The authors began by integrating **data** from multiple large **data** sets of yeast protein interactions, to create a unifi ed set of over 9,000 interactions among almost 3,000 proteins, more than three times as much information on which previous models have been built. As in previous work, certain proteinsthe hubs-emerge as being highly connected, binding to and interacting with many more partners than expected by chance. But the previously identifi ed trend for hubs to avoid interaction with one another disappeared in the large **data** set, a result that persisted as the **data** were sifted through several different kinds of analytic fi lters. Hubs