Whole - genome sequencing ( WGS ) and a Genomizer analysis ( v 10.1.0 ) were used to conduct a comprehensive and unbiased ranking of other potential genetic risk modifiers , including those associated with a lower risk of Alzheimer 's dementia , helping to exclude other potentially protective genetic factors 10 . For processing the WGS data , the same dragen pipeline described above was used . The data was aligned to the GRCh37 decoy genome ( hs37d5 ) . Variants that were called at a depth of < 10X were filtered out and then were annotated using Ensembl 's Variant Effect Predictor ( VEP ) tool . The version of VEP using was v93 . The filtered and annotated set of variants was then compiled for Genomizer analysis . Further information can be found in the Life Sciences Reporting Summary .