Statistical analysis. Between-group comparisons of normally distributed measurements were assessed by Student's t-test. One-way analysis of variance was used to compare more than two **data** groups and Dunnett's post-test was used to compare each group with a control (untreated) group. Two-way analysis of variance was used to compare multiple **data** groups affected by two independent variables, with a Bonferroni correction to compare groups with each other. Differences were considered statistically significant at Po0.05.
