Rifampicin (600 mg once daily) decreased the Cmax (maximum plasma concentration) and AUCτ (area under the plasma concentration time curve within a dose interval) of voriconazole by 9 3% and 96%, respectively. ###>Le voriconazole a augmenté la Cmax et l’ ASCτ du sirolimus (dose unique de 2 mg) de 556% et 1014% respectivement.