<s>[INST] Are certain individuals at an increased risk of progressing from latent TB infection to TB disease? [/INST] The risk of progression to tuberculosis (TB) disease is higher in certain individuals, including:

Persons with weakened immune systems
Children under the age of five
Persons living with HIV/AIDS
Organ or hematologic transplant recipients
Persons with radiographic evidence of prior healed TB
Those undergoing medical treatments with immunosuppressive agents such as systemic corticosteroids, TNF-alpha antagonists and therapies followingtransplantation
Persons with leukaemia or cancer of the lung, head or neck
Cigarette smokers
Drug or alcohol abusers
Persons with a low body weight
Persons with silicosis, diabetes mellitus and chronic renal failure/hemodialysis
Persons who underwent gastrectomy or jejunoileal bypass
Persons infected with TB within prior 2 years Source: T-SPOT ASIA. Link: https://tspot.asia/resources/frequently-asked-questions/. Field: Lung Disease. Disease: Tuberculosis </s>