<s>[INST] Can I suspend the treatment at any given moment? [/INST] This depends. There are treatments, e.g., the bisphosphonates, that have a residual effect on the skeletal system as they remain bound to the bone for years. Therefore treatments with alendronic acid and zoledronic acid, which are the bisphosphonates with the highest bone binding affinity, have a residual effect that will last for several years after discontinuation. Risedronic acid also has a residual effect but it does not last for as long. 
However, it is important to point out that there are treatments that will lose or diminish any benefits gained within 1 or 2 years of discontinuing the therapy. And so upon suspending treatment with teriparatide (bone-forming agent) or denosumab (antiresorptive agent) osteoporosis patients need to take another treatment to “fix” or maintain the positive effect (this could be an oral or intravenous bisphosphonate). Source: Clinic Barcelona. Link: https://www.clinicbarcelona.org/en/assistance/diseases/osteoporosis/frequently-asked-questions. Field: Rheumatology. Disease: Ostoeporosis </s>