<s>[INST] What physiological mechanisms contribute to obesity? [/INST] Weight loss from reduced-caloric intake triggers a physiological process called metabolic adaptation. Weight loss causes the body to react by slowing the metabolism and altering appetite-regulating hormones, which can make long-term weight-management difficult. Source: Rethink Obesity. Link: https://www.rethinkobesity.com/advocacy-resources/faq.html. Field: Endocrinology. Disease: Obesity </s>