<s>[INST] What are osteoporosis risk factors that cannot be changed? [/INST] These factors include:

– Gender – approximately 80% of cases affect women
– Age – As we age, our bones naturally lose some density and become weaker
– Family history of osteoporosis – Studies show that if either of your parents had it, you are more likely to get it.
– History of broken bones – even one broken bone increases your risk of developing osteoporosis, simply because it shows your bones may already be slightly compromised.
– Size of body frame – people with smaller frames are more prone to osteoporosis. Their bones are lighter and thinner. Conversely, a large frame is NOT a defense against the disease.
– Ethnicity – Osteoporosis affects all races and ethnicities, but those of Asian, Latino and Caucasian descent have a higher risk.
– Post-menopausal – There is a steep drop in estrogen after menopause. Estrogen protects the bones. When estrogen decreases, bones may lose density and be prone to fractures. Source: OSC - ORTHO. Link: https://www.osc-ortho.com/frequently-asked-questions-about-osteoporosis/. Field: Rheumatology. Disease: Ostoeporosis </s>