<s>[INST] Why are kidney problems serious? [/INST] Our kidneys function as one of the main sites to filter out toxins. The removal of waste and the balance of blood electrolyte and hormone concentrations depend on renal function. When the kidneys stop functioning, toxic substances accumulate in the blood vessels, and essential hormones cannot be produced or activated for normal body functions. The imbalanced electrolyte concentration in the blood also promotes the development of pathologies such as hypertension and peripheral neuropathy.17,18  These diseases heavily impact our hearts and brains and may increase mortality.. Source: KLARITY HEALTH LIBRARY. Link: https://my.klarity.health/kidney-disease-faq/. Field: Nephrology. Disease: Kidney Disease </s>