<s>[INST] Do biological therapies have to be taken forever? [/INST] Biological therapies have acceptable safety levels and are very effective, but they do not cure the disease. For this reason, they cannot be discontinued and, in general, they must be taken for life. Once the activity of the disease has been controlled (remission), doses of biological drugs can sometimes be reduced or spaced out. A small percentage of patients are able to stop taking them by keeping some maintenance treatment with DMARDs.  Source: Clinic Barcelona. Link: https://www.clinicbarcelona.org/en/assistance/diseases/rheumatoid-arthritis/frequently-asked-questions. Field: Rheumatology. Disease: Arthritis </s>