<s>[INST] What should I know about kidney disease? [/INST] Renal function is linked with multiple organs and body functions via the blood, including fertility, blood pressure, blood glucose, protein level regulations, etc. Defects in renal functions are, therefore, a typical complication of other diseases. Multiple other diseases, such as high blood pressure and diabetes, can cause kidney disease. As a result, the severity of the disease can be regulated by monitoring the risk factors. 

Kidney disease can also lead to other conditions. For example, when CKD occurs, the decreased GFR would trigger the rise of aldosterone concentration. This may lead to hyperaldosteronism when the adrenal function is also impaired. An excess amount of aldosterone would impair the kidneys’ ability to reabsorb water by creating a high salt concentration, it also overloads the kidneys’ filtration system with potassium, further damaging the system. Due to the high blood concentration and lack of water, high blood pressure could be induced. Source: KLARITY HEALTH LIBRARY. Link: https://my.klarity.health/kidney-disease-faq/. Field: Nephrology. Disease: Kidney Disease </s>