<s>[INST] What is end stage renal disease? [/INST] End stage renal disease (ESRD) is total and permanent kidney failure. When the kidneys fail, the body retains fluid and harmful waste builds up. If you have ESRD, you will need dialysis or a kidney transplant to stay alive. Source: FRESENIUS KIDNEY CARE. Link: https://www.freseniuskidneycare.com/frequently-asked-questions. Field: Nephrology. Disease: Kidney Disease </s>