Prenatal Genetics - Sheffield Children’s NHS Foundation Trust Skip to main content A A A Toggle High Contrast EmailMobile Site search Search Search files File search Service search Service search 2 Refine search: Documents People Services Home Patients & Parents Services Refer to us About us Contact us Resource Library Staff A-Z Latest news Feedback Research Site search Search Search files File search Service search Service search 2 Refine search: Documents People Services Also in this section A-Z of services Clinical Genetics Cancer Genetics Prenatal Genetics Ehlers-Danlos Syndrome Service Huntington’s Disease Research Prenatal Genetics Home Services Clinical Genetics Prenatal Genetics Contact us Department of Clinical Genetics OPD2 Northern General Hospital Herries Road Sheffield S5 7AU call 0114 271 7025 email sheffield.clinicalgenetics@nhs.net To speak to the Trust switchboard call 0114 271 7000 Meet the team We hold a weekly prenatal clinic at the Jessop Wing of the Royal Hallamshire Hospital where we see pregnant women. We may see them because something has been picked up in the pregnancy or we may already know the family for a pre-existing genetic condition. Occasionally it is appropriate to offer testing during pregnancy and this is called prenatal diagnosis. Pre-implantation Genetic Diagnosis (PGD) Service PGD is available to a couple at risk of having a child with a specific genetic or chromosomal disorder. It allows the birth of an unaffected child by testing an embryo before it is implanted in the uterus. This technique is very complex and not suitable or appropriate for everyone. There are a large variety of genetic disorders and chromosomal disorders but PGD is only available for conditions approved by the Human Fertilisation & Embryology Authority. We are a PGD satellite unit for Guy’s Hospital, London. How to be referred Please ask your GP or clinician to refer you to Dr Quarrell at the Sheffield Clinical Genetics Service, Sheffield Children’s Hospital, Western Bank, Sheffield S10 2TH. The process PGD involves the use of Assisted Reproductive Technology (ART) to produce and fertilise eggs. If fertilisation is successful, after a few days, one or two cells are removed from the embryo and tested for the altered gene or chromosomal abnormality. If an unaffected embryo is produced it is the transferred to the womb or uterus. The egg collection and embryo transfer parts of the process take place in Guy’s Hospital, London, but we can organise the initial appointments and start the IVF locally. The PGD website at Guy’s Hospital provides useful information about PGD such as what to expect at appointments, success rates, limitations and all the steps involved in the process. A sample case A couple have a child with cystic fibrosis. They would like to extend their family but want to avoid having a second child with this condition. Also, they do not want to consider termination of pregnancy. The couple want to find out more about PGD so there is an initial appointment to discuss this and their other options. From 1 April 2013 criteria for funding PGD are set nationally to avoid variation depending on where you live. If the decision is made to go ahead, then the fertility tests are arranged in collaboration with the GP and the Assisted Conception Unit (ACU) which is based at the Jessop Wing, Royal Hallamshire Hospital, Sheffield. Blood samples are then sent to Guy’s Hospital, London where they confirm if they will be able to get a result from a single cell taken from each embryo. Once all the checks are in place the in vitro fertilisation (IVF) part of the process can be started locally in Sheffield. Depending on the complexity and whether a pregnancy is achieved, the whole process can take between 12 and 18 months. Clinics Clinics are held at Sheffield Children’s Hospital and at the Assisted Conception Unit (ACU) Jessop Wing, Royal Hallamshire Hospital. Clinicians wishing to make a referral should send a referral letter to: Dr Oliver Quarrell Consultant Clinical Geneticist Sheffield Children’s Hospital Western Bank Sheffield S10 2TH You might also be interested in... Clinical Genetics Clinical Genetics Cancer Genetics Cancer Genetics Sheffield Diagnostic Genetics Service Sheffield Diagnostic Genetics Service A-Z of services Clinical Genetics Cancer Genetics Prenatal Genetics Ehlers-Danlos Syndrome Service Huntington’s Disease Research Contact us Department of Clinical Genetics OPD2 Northern General Hospital Herries Road Sheffield S5 7AU call 0114 271 7025 email sheffield.clinicalgenetics@nhs.net To speak to the Trust switchboard call 0114 271 7000 Meet the team Coronavirus Coronavirus Resources for children and families COVID-19 research Help to transform our extraordinary hospital into something even better. Donate today Sheffield Children's@SheffChildrens Thank you to all the children who turned up in their PJs to see Janine!If you would like to know more about the S… https://t.co/kdKIlEgl9l Quick links Appointment change Charities Feedback Hospital building improvements Jobs Outpatients Maps Parking Travelling to our sites Teams Visiting Wards Emergency Department Handbook Emergency Surgery Online Training Hub https://twitter.com/SheffChildrens https://www.facebook.com/sheffieldchildrenshospitalandcharity https://www.youtube.com/user/Sheffchildrens https://www.instagram.com/sheffieldchildrens/ Text only Accessibility Privacy guidance Your information Terms and conditions Home Patients & Parents Services Refer to us About us Contact us Resource Library Staff A-Z Latest news Feedback Research © Sheffield Children's NHS Foundation Trust As of 1 September 2022, patients and families no longer need to wear face coverings. This applies to all sites.More information on how we are keeping you safe is available here. + By continuing to use the site, you agree to the use of cookies. more information Accept The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this. Close