Treatment of tuberculosis in children Treatment of tuberculosis in children Expert Rev Anti Infect Ther. 2008 Dec;6(6):939-57. doi: 10.1586/14787210.6.6.939. Authors Andrea T Cruz 1 , Jeffrey R Starke Affiliation 1 Texas Children's Hospital, MC 3-2371, 1102 Bates Street, Suite 1150, Houston, TX 77030, USA. acruz@bcm.edu PMID: 19053906 DOI: 10.1586/14787210.6.6.939 Abstract The treatment of children with TB is influenced by a number of factors specific to both the bacterium and the child. We review the variables impacting the selection of individual medications; indications, pharmacology, dosing and side effects for first- and second-line agents; adjunctive therapy; and special cases, including treatment of TB in HIV-infected children and multidrug-resistant TB. Finally, evolving trends in TB therapy, such as the impact of HIV and multidrug-resistant TB on future therapeutics, emerging or re-emerging medication options, shorter-course regimens and immunomodulation, are discussed. Publication types Review MeSH terms Adolescent Antitubercular Agents / administration & dosage Antitubercular Agents / adverse effects Antitubercular Agents / therapeutic use* Breast Feeding Chemotherapy, Adjuvant Child Child, Preschool Combined Modality Therapy Drug Resistance, Multiple, Bacterial Female HIV Infections / complications Humans Infant Infant, Newborn Pregnancy Risk Factors Tuberculosis / complications Tuberculosis / drug therapy* Substances Antitubercular Agents