Ruoho, Arnold E. – Neuroscience Training Program – UW–Madison Skip to main content University of Wisconsin–Madison UW Crest Neuroscience Training Program Search Menu open menu close People Expand Collapse Faculty Trainers Faculty Affiliates Students Staff Alumni Research Expand Collapse Research Overview Behavioral, Cognitive, and Affective Neuroscience Cellular and Molecular Neuroscience Development, Plasticity, and Repair Neurobiology of Disease Systems and Circuits Prospective Students Expand Collapse Welcome Admissions Requirements Admissions Checklist Admissions Questions (FAQs) Application Fee Grants Check your Application Status International Applicants Funding UW & City of Madison Current Students Expand Collapse New Student Info NTP Peer Mentoring Program Program Requirements Handbook Forms Time to Degree Mid-Levels Graduation/Oral Defense Neuro Minor NTP Seminar and Subgroups Resources Expand Collapse NTP Health and Wellness GAINS Campus Resources Victim Resources Funding Opportunities Teaching Resources Journal Clubs Careers in Science Travel Policies Undergraduates Outreach Expand Collapse NTP Outreach For Teachers Lending Library Brain Waves Newsletter Diversity Expand Collapse NTP Anti-Racist Pledge Solidarity with the APIDA Community Diversity Enhancement UW-Madison Land Acknowledgement Statement Diversity and Inclusion Resources Diversity Enhancement Committee News and Events Neuro & Public Policy Contact Us Make a Gift Home Arnold E. Ruoho Arnold E. Ruoho Position title: Professor, Department of Neuroscience Email: aeruoho@wisc.edu Phone: (608) 263-5382 Education: Ph.D. University of Wisconsin- Madison Research Focus: G-Protein Receptors, G-Proteins, Neurotransmitter Transporters and Sigma Receptors Research Description: The effort in my laboratory is directed at an understanding of the molecular mechanisms which underlie neurotransmitter release and receptor activation. Several families of proteins which are of specific biochemical interest to us are: (a) beta-adrenergic receptors and rhodopsin (b) GTP binding proteins, (c) catecholamine transport proteins, and (d) sigma receptors. Projects to identify structural and functional domains of adrenergic receptors and G-proteins include: (a) intermolecular interactions between G-proteins and receptors; (b) identification of the G-protein alpha-subunit interaction domain with effectors, such as the enzyme, adenylyl cyclase, and the gamma-subunit of cGMP phosphodiesterase; and (c) the three-dimensional structure of active domains of the G-protein linked receptors and adenylyl cyclase using NMR and crystallography approaches. These experiments utilize multiple methodological approaches, including baculovirus expression of receptors, synthesis and use of agonist and antagonist photoaffinity labels, and the application of ‘tethered’ photoactivatable molecules to probe G-protein structure and nearest neighbor interactions. Link to Publications Site footer content University logo that links to main university website Quick Links Student Resources Program Requirements Faculty Trainers Students Admissions Requirements Contact Us 9531 WIMR II 1111 Highland Ave. Madison, WI 53705 Map map marker Email: ntp@mailplus.wisc.edu Phone: 608-262-4932 facebook linkedin twitter youtube instagram Website feedback, questions or accessibility issues: ntp@mailplus.wisc.edu. Learn more about accessibility at UW–Madison. This site was built using the UW Theme | Privacy Notice | © 2022 Board of Regents of the University of Wisconsin System.