Are there any open mathematical puzzles? Are there any (mathematical) puzzles that are still unresolved? I only mean questions that are accessible to and understandable by the complete layman and which have not been solved, despite serious efforts, by mathematicians (or laymen for that matter)?
My question does not ask for puzzles that have been shown to have either no solution or multiple solutions (or have been shown to be ambiguously formulated).

Existence of odd perfect numbers. (Numbers which are the sum of their own proper divisors). This one has withstood over 2000 years of effort.
