STK35L1
STK35L1 is predominantly found in the nucleus and the nucleolus. Nuclear actin was identified as a novel binding partner of STK35L1. However, it can interact with PDLIM1/CLP-36 in the cytoplasm and localize to actin stress fibers. STK35L1 regulates the expression of CDKN2A and inhibiting G1- to S-phase transition. Depletion of STK35L1 by siRNA impaired endothelial cell migration. STK35L1 may act as a central kinase linking the cell cycle and migration of endothelial cells.
Functions
It has been designated as STK35L1.