I be look for a bag for casual purpose , like hike . this be a bag of good compromise . too small , you can not hold more than a couple of spare lens . too big , it start to look weird and bulky . yet it be roomy enough to allow creativity . I have look around and for its size , 5608 hold the most stuff . without hood , I can fit the follow all in the main compartment : - 40d with f2 .8 17-55mm attach - 10-22mm - 100mm macro - tamron 70-300mm - tamron 1.4 x tele convertor - 430ex - macro flash -lrb- big -rrb- - dust blower - a disposable water bottle -lrb- for hike -rrb- . the bottle can be replace with 70-200 f4 , I suspect . sure it be pack , but everything be still well padded . I do not have a 2nd body , but you can replace a lens with a 2nd body , no attach lens . I would not recommend get this as you only bag if you have 2 body , since 2 lens have to be put under the body and that make change lens inconvenient . I put the least used macro lens underneath the body and on the other side , I put 2 lens upright instead of top\/bottom .