I suppose a laser mouse would be a small improvement , but the optical mouse provide be quite good enough . just remember to turn it off when not in use . the keyboard be quiet and feel just right . the special key for automatic connection to email , Internet , control sound , etc , work properly - without additional software . the o\/s on my desktop be Vista Home . I have not test it on my laptop or Netbook , both run xp . but I be sure keyboard and mouse would work just as well on they . it take only ten minute to unpack , install , boot-up my computer , and write this review . I 'll update after I have use it a while . \*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\* Update : 12-18-2010 \*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\* after use the mk320 for several day , I can testify that the Logitech MK320 Keyboard and Mouse be a excellent choice for anyone own a desktop or portable computer run Windows Vista OS . I be order a second mk320 for my xp Desktop computer . it be presently connect to a old wire -lrb- no brand -rrb- keyboard and mouse . they be past due for the junk yard . \*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\* UPDATE : 2\/8\/11 \*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\*\* the second keyboard come and have be in use for about ten day . it be as nice as the first . I have it plug into my second desktop -lrb- xp os -rrb- . I sometimes unplug it and use it on my netbook -lrb- also xp os -rrb- . it be easily identify on both computer and it make a great difference - especially with the Netbook . I be use the include alkaline battery , but I be think about use my nimh rechargeable battery when the alkaline battery die . this be no big deal . the convenience of this keyboard and mouse be worth the possible alkaline battery expense . also , I be a touch typist and this keyboard give I no problem keep up to my natural speed . it feel right and it perform right . I can not imagine a better deal . I have raise my rating from four star to five star .