MATERIAL FOR BLOOD PURIFICATION
FIG1 is a view showing the opening portions and the non-opening portions in the material for blood purification in the form of a knitted fabric  FIG2 is a schematic view of a circuit and a device used in a pressure loss measurement test 
The opening ratio means a ratio of the opening portions to the sum of the opening portions (3 in FIG1) and the non-opening portions (2 in FIG1) in the material for blood purification in the form of a knitted fabric, and is a value obtained by image processing. Specifically, the opening ratio is calculated using the following procedures.  A pressure loss of the material for blood purification in the form of a knitted fabric can be measured by laminating layers of the material for blood purification in the form of a knitted fabric and allowing simulated blood to pass through the laminate perpendicularly. In this regard, the simulated blood refers to a solution set so as to have the same rate of shear as that of human blood, and examples of the simulated blood include a 50 wt% glycerin aqueous solution. A specific measurement method will be described below. First, layers of the material for blood purification in the form of a knitted fabric are laminated in a container having an inlet and outlet at the top and bottom. The material for blood purification in the form of a knitted fabric is set to have a loading density of 0.30 g/cm3 in the container. Next, simulated blood is allowed to pass through the container at a given flow rate, and the inlet pressure and outlet pressure are each measured. Then, a pressure loss can be determined by subtracting the outlet pressure value from the inlet pressure value. The flow rate (mL/min) of simulated blood in measurement is set on the basis of 100mL/min per 145 cm3 of container volume, taking clinical practice of blood purification into consideration. With a container having a volume of, for example, 5 cm3, a measurement is carried out with the flow rate set at 100 mL/min/ 145 cm3 × 5 cm3 = 3.4 mL/min. A schematic view of a circuit and a device used in a pressure loss measurement test is shown in FIG2. In FIG2, simulated blood or human blood 5 which is ready for passing through a column 4 is sucked up using a pump 10 and is allowed to pass through the column 4. At this time, an inlet pressure measurement device 8 and an outlet pressure measurement device 9 are used to measure the respective pressures to thereby determine a pressure loss. Simulated blood or human blood 5 which is ready for passing through the column is kept in a constant temperature water bath 11 at a constant temperature of 37°C. In addition, a constant temperature water bath 11 is kept at constant temperature using a heater 12. For a circuit 7, a commercially available blood circuit can be used.
schematic view, view
7
Material
12
Material
11
Material
2
Material
64
mixed with
6
in Table
10
in Table
3
Material
['1. A material for blood purification, the material comprising a water-insoluble material in which a ligand having an amide group(s) and an amino group(s) is bound to a substrate, wherein the content of the amide group(s) is 3.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material; and wherein the content of the amino group(s) is 1.0 to 7.0 mmol per 1 g dry weight of the water-insoluble material.']