DIAGNOSTIC IMAGING HEPATIC TISSUE-SPECIFIC CONTRAST MEDIUM COMPRISING MANGANESE SILICATE NANOPARTICLE
FIG9c is a graph showing the relationship between the concentration of Mn2+ ions and the contrast intensity (R1) of the image
Next, the relationship between the concentration of Mn2+ ions and the contrast intensity R1 of the image is shown in the graph of FIG9c. The slope of this graph is expressed as r1, and is a unique value for each material. It was confirmed that the three particles had a similar slope within the range of 7.5 ∼ 8.2, and the increase in the contrast effect by Mn2+ ions was confirmed again by comparing with an r1 value of about 7.4 for pure Mn2+ ions (MnCl2 aqueous solution).
graph
3
Example
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Example after pre-injection level. hours.
['16. The liver tissue-specific MRI contrast agent according to claim 15, wherein the MRI change pattern over time obtained after administration of the contrast agent has a pattern in which is gradually brightened, and after reaching the maximum brightness, is gradually darken in normal liver tissue.']