DIAGNOSTIC IMAGING HEPATIC TISSUE-SPECIFIC CONTRAST MEDIUM COMPRISING MANGANESE SILICATE NANOPARTICLE
FIG2 is a schematic diagram of T1-weighted image and function mechanism after intravenous injection of HMS (3 mg / kg) into a hepatocellular carcinoma (HCC) model
As a result of FIG2, the significant contrast enhancement was observed for 0.5-6 hours after the injection of HMS, and then it slowly began to brighten from the periphery region to the center region for 6-24 hours, and the necrotic area was not enhanced.
schematic diagram
2
Example after pre-injection level. hours.
['16. The liver tissue-specific MRI contrast agent according to claim 15, wherein the MRI change pattern over time obtained after administration of the contrast agent has a pattern in which is gradually brightened, and after reaching the maximum brightness, is gradually darken in normal liver tissue.']