(He rises from his desk. Sheldon: Oh, alright, this is Missy, Missy this is Leonard and Rajesh and you've already met Howard. Leonard, Howard and... You'll stay with us. Scene: The apartment. Uh, Penny, this is Sheldon's twin sister, Missy. (He waves his hand. Raj: So, Missy. Missy: Bye guys. Leonard: Sheldon, can I talk to you in private? Howard: Who are you to decide that? Sheldon: Now that Leonard's made me aware of how high the genetic stakes are, we have to face the fact that none of you are suitable mates for my sister. Sheldon: In principle you have a point, but as a practical matter, need I remind you that it takes experimental pharmaceuticals to simply enable you to speak to the opposite s*x.
Raj (waving finger at him): I think you're focussing entirely too much on the drugs. Sheldon: Why does everyone suddenly want to talk to me alone? Usually nobody wants to be alone with me. Missy can date whoever she wants. Leonard: I agree. Raj: She's not hiding. She needed privacy to call her grandmother who's apparently very sick. Oh, and then I believe she has to wash her hair. Leonard: And he's down! I've come to call on Missy. Penny: Oh, honey, is your medication wearing off? (Raj attempts to speak. Had to put him down.
Plan: A: a drug trial; Q: What does Raj decide to take part in to cure his inability to talk to women? A: Leonard; Q: Who convinces Sheldon he is Missy's guardian? A: the apartment; Q: Where does Leonard insist Missy stay with them? A: Penny; Q: Who comes to Missy's rescue when the men all awkwardly flirt with her? A: all three guys; Q: Who does Sheldon deem unsuitable for Missy? A: her brother; Q: Who does Missy confront about Sheldon's plan to find her a mate? A: simple conjuring tricks; Q: What does Howard try to do to charm Missy? A: interest; Q: What does Missy show in Raj? A: the drug; Q: What causes Raj to be unable to speak to Missy? Summary: Sheldon introduces his twin sister Missy to the guys, and all are attracted to her. Raj decides to take part in a drug trial to cure his inability to talk to women, and Leonard insists Missy stay with them at the apartment. Predictably, the men all awkwardly flirt with her, so Penny comes to her rescue. Leonard, hoping for an advantage over Howard and Raj, convinces Sheldon he is Missy's guardian as concerns her choice of partner. Sheldon deems all three guys to be unsuitable for her. On learning of Sheldon's plan to find her a suitable mate, Missy confronts her brother, and after she kicks him in the groin he agrees she can date whoever she likes. She turns down Leonard, and then Howard, who fails to charm her with simple conjuring tricks. Finally Raj goes to talk to Missy, who shows interest in him, but the drug wears off and he is unable to speak to her, forcing Raj to leave defeated.