query: Can you die from leptospirosis?
passage: Leptospirosis
It is estimated that seven to ten million people are infected by leptospirosis annually.[10] One million cases of severe leptospirosis occur annually, with 58,900 deaths.[34] Annual rates of infection vary from 0.02 per 100,000 in temperate climates to 10 to 100 per 100,000 in tropical climates.[30][35] This leads to a lower number of registered cases than likely exists. The highest estimates of disease morbidity and mortality were observed in South and Southeast Asia, Oceania, Caribbean, Andean, Central, and Tropical Latin America, and East Sub-Saharan Africa.
passage: Lymphocystivirus
Lymphocystis disease is a chronic disease that rarely causes mortality. Infection causes transformation and hypertrophy (approximately 1000x) of cells in the dermis, forming grossly visible lymphocystis nodules, as well as transformation and hypertrophy in cells of the connective tissues of various internal organs. Fibroblasts and osteoblasts are specifically targeted by the virus. Lymphocystis viruses are not easily grown in cell culture, placing limitations on "in vitro" molecular pathogenesis experiments.