query: How many people get organophosphate poisoning each year in the US?
passage: Organophosphate poisoning
OPs are one of the most common causes of poisoning worldwide.[2] There are nearly 3 million poisonings per year resulting in two hundred thousand deaths.[2][3] Around 15% of people who are poisoned die as a result.[2] Organophosphate poisoning has been reported at least since 1962.[7]
passage: Carbophenothion
Carbophenothion is a highly toxic organophosphate insecticide and acaricide. Organophosphates are acetylcholinesterase inhibitors and disrupt the signal transduction at the cholinergic synapse. It is classified as Restricted Use Pesticide (RUP) by the Environmental Protection Agency (EPA). Carbophenothion is used in different brands like Trithion. This pesticide contains 80% carbophenothion as its only active ingredient. Because of the widespread use of those organophosphates in the nineties in the US, it was the most common cause of agricultural poisonings.